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Postpartum bleeding

Postpartum bleeding, also known as postpartum hemorrhage (PPH), is the excessive loss of blood following childbirth. According to the 2025 consolidated guidelines from the International Federation of Gynecology and Obstetrics (FIGO) and the World Health Organization (WHO), to identify women at risk of adverse outcomes from postpartum bleeding and initiate first-response treatment, it is recommended to use the following criteria: objectively measured blood loss of ≥300 mL with any abnormal haemodynamic sign (pulse >100 bpm, shock index >1, systolic blood pressure <100 mmHg, or diastolic blood pressure <60 mmHg), or objectively measured blood loss of ≥500 mL, whichever occurs first within 24 hours after birth, with particular vigilance during the first 2 hours.^[1] This condition can be primary (occurring within 24 hours) or secondary (up to 12 weeks postpartum) and represents a major obstetric emergency that requires prompt recognition and intervention to prevent severe maternal morbidity or mortality.^[2] Globally, PPH is the leading direct cause of maternal death, accounting for approximately 70,000 fatalities annually, with incidence rates varying from 1-3% of deliveries worldwide.^[3]^[2] The primary causes of PPH are often summarized by the "4 Ts": Tone (uterine atony, responsible for about 70% of cases, where the uterus fails to contract effectively after delivery), Trauma (genital tract lacerations or uterine rupture), Tissue (retained placental fragments), and Thrombin (coagulation disorders).^[2] Risk factors include advanced maternal age, multiple gestation, prolonged labor, cesarean delivery, placenta previa or accreta, and pre-existing conditions such as anemia or coagulopathies like von Willebrand disease.^[2]^[4] In the United States, rates of severe PPH have risen, contributing to increased maternal mortality, with recent data showing up to 40 cases per 10,000 deliveries as of 2024.^[2] Prevention strategies emphasize active management of the third stage of labor, including administration of uterotonics like oxytocin (10 IU intramuscularly) immediately after delivery, controlled cord traction, and uterine massage.^[2] Quantitative measurement of blood loss, rather than visual estimation, is recommended to enable early detection.^[2] Treatment involves a stepwise approach: initial resuscitation with intravenous fluids and blood products, pharmacologic interventions (e.g., additional uterotonics such as methylergonovine or tranexamic acid), mechanical methods like uterine balloon tamponade, and surgical options including hysterectomy in refractory cases.^[2]^[4] Multidisciplinary protocols, as outlined by organizations like the American College of Obstetricians and Gynecologists (ACOG) and the World Health Organization (WHO), have significantly reduced mortality rates through standardized care bundles.^[4]^[3]

Overview

Definition and Classification

Postpartum hemorrhage, also known as postpartum bleeding, is defined by the World Health Organization (WHO), International Federation of Gynecology and Obstetrics (FIGO), and International Confederation of Midwives (ICM) as clinically significant when there is blood loss of 300 mL or more accompanied by signs of hypovolemia.^[5] This redefinition, established in their consolidated guidelines in October 2025, aims to enable earlier detection in resource-limited settings by emphasizing clinical indicators such as tachycardia, hypotension, or oliguria alongside quantitative blood loss.^[5] In the United States, the American College of Obstetricians and Gynecologists (ACOG) defines PPH as a cumulative blood loss of greater than or equal to 1,000 mL after delivery or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours of birth, regardless of the route of delivery.^[4] This redefinition, established by ACOG in 2017 as part of the reVITALize initiative, emphasizes both quantitative blood loss and clinical indicators such as tachycardia, hypotension, or oliguria to identify cases requiring intervention more effectively.^[4] The shift to these 2017 criteria was driven by evidence showing improved maternal outcomes through earlier detection, particularly as rates of uterine atony—the most common cause—have risen while overall PPH-related mortality has declined since the 1980s.^[4] Historically, PPH was defined more narrowly as an estimated blood loss exceeding 500 mL after vaginal delivery or 1,000 mL after cesarean delivery, without necessarily incorporating signs of hypovolemia.^[4] This older threshold, rooted in visual estimation practices, often led to underrecognition of clinically significant bleeding because such estimations are prone to inaccuracy and delay.^[4] PPH is classified temporally into primary and secondary (or late) forms to guide clinical assessment and management. Primary PPH occurs within the first 24 hours postpartum and accounts for the majority of cases, often linked to immediate delivery-related factors.^[4] Secondary PPH, in contrast, involves excessive bleeding from 24 hours up to 12 weeks postpartum and is typically associated with delayed complications such as infection or retained placental tissue.^[4] This condition is differentiated from normal postpartum blood loss, which averages approximately 500 mL following vaginal delivery and 1,000 mL after cesarean delivery, without associated hemodynamic instability.^[4] These baseline volumes highlight why thresholds for PPH focus on deviations that pose risks to maternal stability.

Epidemiology

Many epidemiological studies define postpartum hemorrhage (PPH) using older mode-specific thresholds of >500 mL after vaginal delivery or >1,000 mL after cesarean delivery, which may not fully correlate with current definitions such as the ACOG 2017 criteria of a cumulative blood loss of ≥1,000 mL or blood loss accompanied by signs of hypovolemia within 24 hours of birth; under these metrics, the condition affects 1–5% of deliveries worldwide, with incidence rates rising to 10% or higher in low- and middle-income countries due to limited access to timely interventions.^[4]^[6] In 2021, the global burden included nearly 14 million cases, disproportionately impacting regions with weaker healthcare infrastructure.^[7] In the United States, the incidence has shown a marked upward trend, increasing from 2.7% of deliveries in 2000 to 4.3% in 2019, reflecting broader patterns in high-income settings.^[8] PPH remains a leading contributor to maternal mortality, accounting for approximately 27% of all global maternal deaths between 2009 and 2020, equating to nearly 45,000 deaths in 2023 (per recent WHO estimates, down from earlier figures of around 70,000 annually).^[9]^[5] This burden is far greater in developing countries, where PPH causes up to 25–30% of maternal deaths, compared to 8–13% in high-income nations, highlighting stark disparities in outcomes.^[10] Over 80% of PPH-related maternal deaths occur in sub-Saharan Africa and South Asia, where the prevalence of PPH is estimated at 3.8%, nearly double the 2% rate observed in the United States.^[11]^[12] Rising trends in PPH incidence are linked to increases in cesarean delivery rates and maternal obesity, both of which have escalated globally over recent decades.^[13] In the United States, cesarean rates have remained around 32% as of 2023, correlating with higher PPH risk due to surgical complications.^[14] Concurrently, the obesity epidemic has amplified vulnerability, with studies indicating up to a 19% higher risk of PPH among obese women following vaginal deliveries.^[15] Recent global efforts underscore persistent gaps, particularly in low- and middle-income countries, where implementation of evidence-based care remains uneven.^[5] In October 2025, the World Health Organization, International Federation of Gynecology and Obstetrics, and International Confederation of Midwives issued consolidated guidelines on PPH prevention, diagnosis, and treatment to address these challenges.^[16] Complementing this, a WHO-led roadmap for 2023–2030 aims to halve PPH-related maternal deaths through enhanced surveillance, training, and resource allocation in high-burden regions.^[17]

Pathophysiology and Etiology

Primary Causes

Postpartum bleeding primarily arises from disruptions in the normal hemostatic mechanisms following delivery, most commonly framed by the "4 Ts" mnemonic: Tone, Trauma, Tissue, and Thrombin. These etiologies account for the majority of cases, with uterine atony being the predominant cause. A 2025 systematic review and meta-analysis reported the following pooled proportions: uterine atony 70.6% (95% CI 63.9–77.3), genital tract trauma 16.9% (95% CI 9.3–24.6), retained placenta 16.4% (95% CI 12.3–20.5), and coagulopathy 2.7% (95% CI 0.8–4.5).^[18]^[2]^[19] Tone refers to uterine atony, where the myometrium fails to contract effectively after delivery, preventing compression of the spiral arteries at the placental site and leading to continuous bleeding. This occurs due to impaired myometrial function, often from factors like uterine overdistension in multiple gestations or prolonged labor, and represents 70-80% of PPH cases.^[20]^[2] Trauma involves injury to the genital tract, including lacerations of the cervix, vagina, or perineum, as well as hematomas or uterine rupture, which expose bleeding vessels. Such damage is frequently associated with operative vaginal deliveries or cesarean sections, disrupting vascular integrity and accounting for approximately 17% of PPH cases.^[18]^[19] Tissue encompasses retained products of conception, such as placental fragments or membranes, which prevent complete uterine contraction by occupying the endometrial cavity and maintaining open vascular channels. This leads to persistent hemorrhage as the uterus cannot involute properly.^[21]^[2] Thrombin denotes coagulopathies, including inherited disorders like von Willebrand disease or acquired conditions such as disseminated intravascular coagulation (DIC), where impaired clotting exacerbates bleeding from other sites. Massive blood loss in PPH can further deplete fibrinogen, leading to hypofibrinogenemia and a vicious cycle of hemorrhage.^[18]^[19] Less common causes include iatrogenic factors, such as overzealous cord traction causing uterine inversion, or rare events such as uterine artery pseudoaneurysms, which can mimic or compound the primary etiologies. Uterine atony is the predominant cause of PPH worldwide, including in low-resource settings where anemia is a common risk factor. The 2025 WHO guidelines emphasize the importance of addressing anemia to prevent PPH.^[5]

Risk Factors

Risk factors for postpartum bleeding, also known as postpartum hemorrhage (PPH), are categorized into non-modifiable and modifiable types to facilitate clinical risk stratification and targeted interventions. These factors contribute to the likelihood of excessive bleeding by influencing uterine tone, placental separation, or coagulation mechanisms, though they do not directly cause the hemorrhage.^[2] Non-modifiable risk factors include demographic and historical elements that cannot be altered during pregnancy. Advanced maternal age greater than 35 years increases the risk due to potential declines in uterine contractility and vascular integrity. Grand multiparity, defined as more than four previous births, is associated with uterine atony from overstretching and reduced myometrial efficiency. A history of previous PPH significantly elevates recurrence risk, with odds ratios often exceeding 2 in meta-analyses. Placental abnormalities such as previa or accreta represent inherent anatomical risks that predispose to abnormal implantation and separation. Inherited coagulopathies, including von Willebrand disease, impair hemostasis and are linked to severe bleeding events.^[2]^[22]^[2] Modifiable risk factors encompass obstetric and intrapartum variables that can be influenced through clinical management. Prolonged labor exceeding 12 hours heightens the risk by causing uterine fatigue and atony. Labor augmentation with oxytocin promotes overstimulation, potentially leading to inefficient contractions. Operative deliveries, including cesarean sections and forceps-assisted vaginal births, are associated with higher bleeding incidence due to trauma and delayed uterine involution; cesarean delivery, in particular, carries an odds ratio greater than 2. Multiple gestation and polyhydramnios contribute through uterine overdistension, while macrosomia (fetal weight >4,500 g) exacerbates this effect. Obesity with a BMI greater than 30 kg/m² increases the risk of PPH with an odds ratio of approximately 1.5.^[2]^[22]^[4] Medical conditions further compound vulnerability to PPH. Anemia, a key modifiable factor, affects approximately 40% of pregnancies in low-income settings and amplifies bleeding severity by reducing oxygen-carrying capacity and tolerance to blood loss, as highlighted in the 2025 FIGO guidelines. Preeclampsia predisposes to vascular instability and endothelial dysfunction. Chorioamnionitis, an intrapartum infection, promotes inflammation and coagulopathy. These conditions underscore the need for antenatal screening and management to mitigate hemorrhage risk.^[23]^[24]^[2]

Clinical Presentation and Diagnosis

Signs and Symptoms

Postpartum hemorrhage typically manifests with excessive vaginal bleeding, often described as soaking more than one sanitary pad per hour for more than two consecutive hours.^[25] This bleeding may be accompanied by a boggy uterus upon abdominal palpation, indicating uterine atony, the most common underlying cause.^[2] Early vital sign changes include tachycardia with a heart rate exceeding 100 beats per minute, which may be the initial indicator of significant blood loss, followed by hypotension (systolic blood pressure below 90 mmHg) and tachypnea as hypovolemia progresses.^[26] In severe cases, patients develop signs of hypovolemic shock, such as confusion or altered mental status, oliguria (reduced urine output), and clammy, pale skin due to sympathetic activation and poor perfusion.^[27] Coagulopathy complicating PPH can lead to bleeding from non-genital sites, including the gums or intravenous insertion points.^[2] Secondary PPH often presents with delayed onset around 1 to 2 weeks after delivery.^[28] If infection-related, such as endometritis, additional symptoms include fever and foul-smelling lochia.^[3] The 2025 WHO consolidated guidelines highlight the role of subjective symptoms like dizziness in early recognition, especially in resource-limited settings where accurate blood loss measurement is difficult, alongside abnormal vital signs at blood losses as low as 300 mL.^[1] These manifestations necessitate prompt clinical assessment to confirm the diagnosis.^[4]

Diagnostic Approaches

Diagnosis of postpartum hemorrhage is based on recognition of excessive blood loss or signs of hypovolemia. Clinical estimation through visual assessment of blood loss is commonly employed but is notoriously inaccurate, frequently underestimating the volume by approximately 30-50% compared to quantitative methods. To improve accuracy, quantitative techniques such as calibrated drapes or collection bags are recommended for measuring blood loss, enabling earlier detection and intervention.^[29]^[30]^[24] A thorough physical examination is essential to identify the source of bleeding and assess uterine tone. This includes inspection of the perineum, vagina, cervix, and uterus for lacerations, hematomas, or retained tissue, as well as bimanual palpation to evaluate uterine contraction and perform compression if needed. Abdominal palpation every 15 minutes in the first postpartum hour helps detect uterine atony, the most common cause, by identifying a soft or boggy uterus. Genital tract examination is also critical to rule out trauma or incomplete placental expulsion.^[31]^[24] Laboratory tests support the diagnosis by quantifying the impact of blood loss and evaluating for coagulopathy. A complete blood count assesses hemoglobin levels, with a drop indicating significant hemorrhage, while blood typing and crossmatching prepare for potential transfusion. Coagulation profiles, including prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen levels, are indicated if bleeding persists; fibrinogen below 200 mg/dL signals severe coagulopathy and increased risk of progression. These tests, though not always immediately available, guide transfusion decisions in ongoing cases.^[2]^[32] Imaging modalities are used selectively when clinical findings suggest specific etiologies. Point-of-care ultrasound is valuable for detecting retained products of conception, appearing as hyperechoic material within the endometrial cavity, and is particularly recommended in low-resource settings for its accessibility and non-invasiveness. Rarely, computed tomography (CT) or magnetic resonance imaging (MRI) may be employed in complex cases to evaluate for intra-abdominal bleeding or vascular abnormalities if initial measures fail.^[33]^[24]

Prevention

Antenatal and Intrapartum Strategies

Antenatal strategies to prevent postpartum bleeding focus on identifying and mitigating modifiable risk factors through routine screening and interventions. Planning for active management of the third stage of labor (AMTSL) is recommended during prenatal visits, particularly for women at elevated risk, to ensure timely implementation during delivery. Correction of anemia via oral or intravenous iron supplementation is advised for pregnant individuals with hemoglobin levels below 11 g/dL in the first and third trimesters or below 10.5 g/dL in the second trimester, as anemia increases PPH risk by impairing oxygen delivery and coagulation. Screening for coagulopathies, such as von Willebrand disease or inherited thrombophilias, should occur in women with a personal or family history of bleeding disorders or unexplained anemia, allowing for targeted prophylaxis like fibrinogen replacement if needed. Intrapartum measures emphasize optimizing labor progression and employing standardized protocols to minimize uterine atony and trauma. Dystocia and prolonged stages of labor should be avoided through vigilant monitoring of progress and timely interventions such as augmentation with oxytocin or cesarean delivery if labor arrest occurs, as extended labor can lead to maternal exhaustion and uterine fatigue, heightening PPH risk. Judicious use of oxytocin for labor augmentation is recommended, starting at low doses (e.g., 1-2 mU/min) with close fetal monitoring to prevent hyperstimulation, which can lead to abnormal contractions and increased bleeding potential. Controlled cord traction, performed only by skilled providers, is integrated with uterotonics during AMTSL to facilitate placental expulsion and reduce blood loss. For high-risk pregnancies, such as those with placenta previa or accreta, protocols include antenatal preparation of blood products (e.g., cross-matched packed red blood cells and fresh frozen plasma) and involvement of a multidisciplinary team comprising obstetricians, anesthesiologists, and hematologists to coordinate care and enable rapid response. The 2025 WHO guidelines endorse universal AMTSL—comprising prophylactic oxytocin administration (10 IU IM/IV), controlled cord traction, and uterine massage—citing evidence of a 60% reduction in PPH incidence compared to expectant management. Additionally, the FIGO 2022 recommendations stress simulation-based training for providers, including unit-based drills on AMTSL and hemorrhage protocols, to enhance competency and reduce implementation errors in resource-limited settings.^[34]

Prophylactic Pharmacotherapy

Prophylactic pharmacotherapy plays a central role in preventing PPH by promoting uterine contraction immediately after delivery, primarily through the administration of uterotonics as part of AMTSL.^[1] The World Health Organization (WHO) recommends routine use of these agents in all births to reduce the incidence of excessive blood loss.^[1] Oxytocin is the first-line uterotonic for PPH prevention, administered at a dose of 10 international units (IU) intramuscularly (IM) or intravenously (IV, slowly over 1-2 minutes) immediately after birth or at delivery of the anterior shoulder.^[1] This intervention significantly reduces the risk of PPH, with meta-analyses showing approximately a 50% relative risk reduction for blood loss ≥500 mL compared to no uterotonic.^[35] Its efficacy is supported by high-certainty evidence from randomized controlled trials, making it suitable for both vaginal and cesarean deliveries in settings with skilled personnel and cold chain storage.^[35] In low-resource settings where oxytocin is unavailable or storage is challenging, misoprostol serves as an effective alternative, given as a single 400-600 microgram (mcg) oral dose within 1 minute of birth.^[1] This prostaglandin E1 analogue induces uterine contractions and is particularly valuable for community-based or unsupervised deliveries due to its heat stability and ease of administration.^[1] Heat-stable carbetocin (100 mcg IM or IV) is another option in such contexts, offering comparable efficacy to oxytocin with moderate- to high-certainty evidence.^[1] For women at high risk of PPH without contraindications such as hypertension or asthma, ergometrine (0.2 mg IM, often combined with oxytocin as Syntometrine) may be considered adjunctively, though routine prophylactic use is not recommended due to risks of hypertension.^[1] Carboprost (250 mcg IM) is generally reserved for treatment rather than prophylaxis but can be used in refractory high-risk cases if other agents fail.^[1] Recent evidence from 2025 guidelines emphasizes avoiding routine ergometrine to minimize adverse effects, while consolidating oxytocin as the standard.^[1] Tranexamic acid (TXA), an antifibrinolytic agent, is primarily recommended for therapeutic use in active PPH but shows promise for prophylaxis in select high-risk cases, such as cesarean deliveries in women with anemia or prior PPH, at a dose of 1 g IV within 3 hours of delivery.^[36] Systematic reviews indicate it reduces intraoperative blood loss and PPH incidence in these scenarios, though universal prophylaxis is not endorsed due to limited broad evidence and potential thrombotic risks.^[37] The 2025 WHO guidelines highlight TXA's role mainly in treatment bundles, with ongoing research addressing prophylactic applications.^[1]

Management

Initial Assessment and Supportive Care

Upon suspicion of postpartum hemorrhage, the initial response prioritizes rapid stabilization through the ABC approach—ensuring airway patency, adequate breathing with supplemental oxygen if needed, and circulation support—to maintain hemodynamic stability and organ perfusion.^[2] Immediate activation of a multidisciplinary team via a massive hemorrhage protocol is essential, with the 2025 WHO/FIGO/ICM consolidated guidelines recommending initiation of the first-response treatment bundle (E-MOTIVE: early detection of postpartum hemorrhage using a calibrated blood-collection drape, uterine Massage, Oxytocin/uterotonics, controlled cord Traction, additional Interventions including tranexamic acid and intravenous fluids, and Empty bladder with full Examination) within 15 minutes of PPH diagnosis to minimize delays in care.^[24]^[1]^[38] This involves summoning obstetrics, anesthesiology, nursing, and laboratory personnel for coordinated action, often shifting the patient to an operating room if severe bleeding is evident.^[2] Vital signs monitoring is critical, with continuous assessment of blood pressure, heart rate, respiratory rate, and oxygen saturation every 15 minutes initially to detect hypovolemia early, using indicators like tachycardia (pulse >100 bpm), hypotension (systolic BP <100 mmHg), or shock index >1.^[24] Two large-bore intravenous lines (14- or 16-gauge) should be established promptly for access, followed by fluid resuscitation using 1-2 liters of isotonic crystalloids such as Ringer's lactate to restore volume and prevent shock, while avoiding over-resuscitation.^[2]^[39] Bimanual uterine massage is performed concurrently to expel clots, assess uterine tone, and promote contraction, serving as a first-line mechanical intervention in the absence of other causes.^[24] Blood loss quantification occurs via objective methods, such as weighing pads or sponges or using calibrated drapes or collectors, to accurately track cumulative volume and guide escalation, with PPH thresholds set at ≥300 mL accompanied by abnormal vital signs or ≥500 mL within 24 hours postpartum.^[36]^[2]

Pharmacological Interventions

Pharmacological interventions form the cornerstone of medical management for active PPH, aiming to promote uterine contraction, stabilize coagulation, and reduce blood loss through targeted drug administration. These treatments are typically initiated following initial supportive care, such as fluid resuscitation and uterine massage, and escalate based on response. First-line therapies focus on uterotonics to address uterine atony, the most common cause of PPH, while second-line options and adjuncts are employed if bleeding persists.^[1] Oxytocin remains the first-line uterotonic agent, administered as an initial 10 IU IV slowly over 1-2 minutes, followed by a maintenance infusion of 10-20 IU in 500-1000 mL of intravenous fluid over 4-8 hours, adjusted to control bleeding. This promotes sustained uterine contractions without significant cardiovascular side effects in most patients. If oxytocin is ineffective, ergometrine is added at a dose of 0.2 mg intramuscularly every 2-4 hours, up to five doses; however, it is contraindicated in patients with hypertension.^[4]^[1] For refractory cases, second-line uterotonics include carboprost (15-methyl prostaglandin F2 alpha), given as 0.25 mg intramuscularly every 15 minutes, with a maximum of eight doses, as it induces strong myometrial contractions; it should be avoided in patients with asthma due to the risk of bronchospasm. Misoprostol, a prostaglandin E1 analog, serves as an alternative or adjunct at 800-1000 mcg rectally, particularly in resource-limited settings where intravenous access is challenging, though it may cause fever and shivering as side effects. These agents are selected based on availability, patient contraindications, and clinical response, with ongoing monitoring for vital signs and blood loss.^[4]^[1] Adjunctive therapies enhance hemostasis in ongoing bleeding. TXA, an antifibrinolytic, is administered as 1 g intravenously over 10 minutes, with a repeat dose if bleeding continues after 30 minutes or recurs within 24 hours; the WOMAN trial demonstrated that early TXA use (within three hours of onset) reduces mortality from bleeding by approximately one-third (risk ratio 0.81, 95% CI 0.65-1.00). For coagulopathy, fibrinogen concentrates are recommended if plasma levels fall below 2 g/L, targeting restoration to at least 2 g/L to support clot formation, as hypofibrinogenemia is a key driver of severe PPH.^[40]^[1] The 2025 FIGO/ICM/WHO consolidated guidelines emphasize routine TXA administration within three hours for all PPH cases to optimize outcomes, integrating it into the first-response bundle alongside uterotonics. They also advise against routine use of recombinant activated factor VIIa due to its association with increased thrombosis risk and uncertain efficacy in refractory PPH, reserving it only for life-threatening scenarios unresponsive to other measures. These recommendations underscore a stepwise, evidence-based approach to minimize maternal morbidity while avoiding unnecessary risks.^[1]

Non-Surgical Interventions

Non-surgical interventions for PPH focus on mechanical techniques to achieve hemostasis by applying direct pressure or restricting blood flow, typically employed when initial supportive measures fail to control bleeding. These methods are particularly valuable in stabilizing patients, serving as a bridge to definitive treatment if required.^[41] Uterine tamponade involves inserting an intrauterine balloon, such as the Bakri balloon, into the uterus and inflating it with 300-500 mL of saline to exert pressure on the uterine walls and arrest bleeding from atony or lacerations. This device, with a maximum capacity of 500 mL, is placed vaginally after delivery or abdominally post-cesarean, and its efficacy is supported by meta-analyses showing success rates of approximately 85-90% in resolving PPH without further intervention.^[42]^[43]^[44] Aortic compression provides temporary reduction in pelvic blood flow through manual pressure on the abdominal aorta or the use of binders, allowing time for resuscitation and other interventions. This low-tech maneuver, applicable in resource-limited settings, is endorsed in international guidelines as an immediate step to mitigate ongoing hemorrhage.^[45]^[46] Uterine artery embolization, performed via interventional radiology in hemodynamically stable patients, targets specific arterial branches to occlude blood supply to bleeding sites, achieving hemostasis in over 90% of cases while preserving fertility. This procedure involves catheter-guided delivery of embolic agents and is ideal for persistent PPH after delivery.^[47]^[48] Recent updates in the 2025 WHO guidelines emphasize low-cost alternatives like condom-loaded Foley catheters for uterine tamponade in resource-poor settings, highlighting their accessibility and comparable efficacy to commercial balloons. Systematic reviews, including those up to 2024, affirm tamponade devices as effective temporizing measures to facilitate surgical planning if needed.^[49]^[41]

Surgical Interventions

Surgical interventions are employed when postpartum hemorrhage persists despite initial medical and non-surgical measures, aiming to achieve rapid hemostasis while prioritizing fertility preservation where possible. These procedures typically require general anesthesia and an operating room setting, with decisions guided by the ongoing blood loss, hemodynamic instability, and underlying etiology such as uterine atony or trauma.^[2] Conservative surgical techniques focus on uterine compression and vascular control to avoid hysterectomy. Uterine compression sutures, such as the B-Lynch technique—which involves placing a brace suture around the uterus to compress the myometrium—and the Hayman method, which uses multiple longitudinal sutures through the uterine walls, are effective for atony-related bleeding, achieving success rates of up to 90-100% in select cases while preserving fertility.^[2]^[50] Vessel ligation procedures, including bilateral uterine artery ligation (O'Leary sutures) or step-ladder ligation of the uterine and ovarian arteries, reduce pulsatile blood flow to the uterus and succeed in 42-88% of instances, serving as fertility-sparing options before more invasive steps.^[2]^[50] For traumatic causes, direct surgical repair is indicated, involving suturing of cervical, vaginal, or perineal lacerations, or addressing uterine rupture through oversewing and possible additional support. These repairs are performed promptly upon identification during examination, often resolving bleeding without further escalation.^[2]^[36] Definitive surgery, such as hysterectomy, is reserved for refractory cases where bleeding continues despite conservative efforts, typically when estimated blood loss exceeds 1500 mL and is accompanied by hypovolemia. Subtotal hysterectomy, which removes the uterine corpus while leaving the cervix, is often preferred over total hysterectomy due to its shorter operative time and reduced intraoperative blood loss, facilitating quicker control in emergencies.^[2]^[50]^[18] Recent advancements include the increasing adoption of resuscitative endovascular balloon occlusion of the aorta (REBOA) in advanced care settings, providing temporary aortic occlusion to stabilize hemodynamics and bridge to surgery.^[51]^[50]^[36] The FIGO 2025 recommendations underscore prioritizing fertility-preserving interventions like compression sutures and ligations before proceeding to hysterectomy.^[50]^[36]

Prognosis and Long-Term Outcomes

Complications

Postpartum hemorrhage can precipitate acute life-threatening complications, primarily through profound hypovolemia leading to hypovolemic shock. This condition arises when blood loss exceeds approximately 20% of the maternal blood volume (typically more than 1500 mL), manifesting as tachycardia, hypotension, oliguria, and altered mental status due to inadequate tissue perfusion.^[2] Prolonged hypoperfusion from severe PPH may result in acute kidney injury, as ischemic damage impairs renal function and can lead to acute tubular necrosis if not promptly reversed.^[2] Additionally, extreme blood loss can cause Sheehan's syndrome, a form of postpartum hypopituitarism resulting from ischemic necrosis of the anterior pituitary gland, which enlarges during pregnancy and is vulnerable to hypovolemic insults.^[52] Hematologic derangements represent another critical category of complications, with disseminated intravascular coagulation (DIC) frequently complicating severe PPH due to the release of tissue factor from the uterus and activation of the coagulation cascade. DIC manifests as widespread microvascular thrombosis and bleeding diathesis, exacerbating blood loss and necessitating urgent replacement of clotting factors.^[53] Cases requiring massive transfusion—defined as replacement of more than one blood volume (approximately 10 units of packed red blood cells) within 24 hours—carry inherent risks, including transfusion-related acute lung injury, which involves non-cardiogenic pulmonary edema, and circulatory overload from excessive fluid administration.^[2] Infectious complications often stem from uterine trauma or retained placental fragments associated with PPH, predisposing to endometritis, an ascending bacterial infection of the endometrium characterized by fever, uterine tenderness, and purulent discharge.^[54] If untreated, endometritis can progress to systemic sepsis, with potential for multi-organ dysfunction and high maternal mortality.^[2] Severe PPH cases frequently demand intensive care, as PPH is a leading cause of obstetric ICU admissions, accounting for 17–56% across various studies worldwide.^[55]^[56] Long-term, anemia is common among survivors due to blood loss recovery demands and nutritional deficits, requiring ongoing monitoring and iron supplementation.^[5] Severe PPH is also associated with increased risk of psychological complications, including postpartum post-traumatic stress disorder, affecting 14–25% of affected women.^[57]

Recurrence and Follow-Up

Women who have experienced PPH in a previous pregnancy have an elevated risk of recurrence in subsequent deliveries, with overall rates ranging from 10% to 16%. This risk is similar for cases caused by uterine atony, around 13%. Factors such as inter-pregnancy interval and shared genetic or paternal contributions may further influence recurrence patterns, underscoring the need for individualized risk assessment.^[58]^[59]^[60] Post-discharge follow-up care for women recovering from PPH emphasizes monitoring for persistent anemia and supporting recovery. A hemoglobin check is typically recommended 2-6 weeks after delivery to evaluate iron status and guide supplementation if needed. Counseling on contraception is integral to allow adequate recovery time between pregnancies, while iron therapy is advised for those with confirmed anemia to prevent long-term fatigue and other sequelae.^[26]^[61] Planning for future pregnancies after a history of PPH involves early referral to high-risk obstetric services to implement prophylactic measures, such as active management of the third stage of labor or preparedness for potential interventions. For women with a prior cesarean delivery complicated by PPH, considerations for vaginal birth after cesarean should balance recurrence risks against benefits, often favoring hospital-based care with multidisciplinary support.^[58]^[62] Recent global initiatives, including the 2023-2030 Roadmap to Combat Postpartum Haemorrhage updated in 2025, advocate for enhanced postpartum surveillance systems to track PPH incidence and recurrence, enabling better resource allocation in low- and middle-income countries. FIGO endorses shared decision-making in high-risk cases, empowering women and providers to tailor delivery plans based on prior history and evidence-based options.^[5]^[24]

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Contributing Indications to the Rising Cesarean Delivery Rate - NIH
The cesarean delivery rate in the United States has steadily increased since 1996 when the rate was 21%. In 2007, the rate was the highest ever recorded at 32%, ...
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[PDF] Prevalence and Risk Factors of Postpartum Hemorrhage in ...
Mar 21, 2023 · They demonstrated that obese and overweight women had up to a 19% higher risk of hemorrhage following vaginal delivery, but cesarean deliveries ...
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Save lives. End postpartum haemorrhage: new consolidated ...
Oct 5, 2025 · Of the estimated 260,000 maternal deaths in 2023, nearly 45,000 were attributable to PPH. These preventable deaths are family and community ...Missing: incidence | Show results with:incidence
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A roadmap to combat postpartum haemorrhage between 2023 and ...
Oct 11, 2023 · It affects millions of women every year and accounts for over 20% of all maternal deaths reported globally.<|control11|><|separator|>
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Postpartum Hemorrhage: Overview, Etiology, Diagnosis
Jan 23, 2025 · ACOG defines primary PPH as a cumulative blood loss of at least 1 liter or any bleeding with signs of hypovolemia within 24 hours after delivery ...Missing: authoritative | Show results with:authoritative
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Uterine atony and uterotonics in postpartum haemorrhage - FIGO.org
Oct 4, 2023 · Uterine atony, or inadequate uterine tone, is estimated to cause 70–80% of postpartum haemorrhage and in most cases should be suspected first.
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Postpartum Hemorrhage (PPH): Causes, Risks & Treatment
What are the four Ts of postpartum hemorrhage? The causes of postpartum hemorrhage are often called the four Ts (tone, trauma, tissue and thrombin). The ...Missing: framework | Show results with:framework
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Causes of and risk factors for postpartum haemorrhage - PubMed
Apr 26, 2025 · Risk factors with weak association with postpartum haemorrhage included Black and Asian ethnicity, BMI 25-29·9 kg/m2, asthma, thrombocytopenia, ...
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FIGO call to action: Multisectoral approach to postpartum hemorrhage
Aug 21, 2025 · However, the prevalence of anemia during pregnancy—estimated at approximately 40%—is a significant risk factor for PPH.GUIDELINES AND... · IMPLEMENTATION OF... · MULTISECTORAL APPROACH
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[PDF] Consolidated guidelines for the prevention, diagnosis and treatment ...
Consolidated guidelines for the prevention, diagnosis and treatment of postpartum haemorrhage. Geneva: World Health Organization; 2025. Licence: CC BY-NC-SA 3.0 ...<|control11|><|separator|>
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3 Conditions to Watch for After Childbirth - ACOG
Postpartum hemorrhage is bleeding after birth that's much heavier than usual—meaning you're soaking through two pads an hour for more than 1 to 2 hours.
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Postpartum Hemorrhage: Prevention and Treatment - AAFP
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Hypovolemia and Hypovolemic Shock - StatPearls - NCBI Bookshelf
Jun 1, 2025 · On physical examination, findings often include decreased skin turgor, low jugular venous pressure, prolonged capillary refill time, and ...
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[PDF] Guideline on Prevention and Management of PPH
PPH can be minor (500–1000 ml) or major (more than 1000 ml). Major can be further subdivided into moderate (1001–2000 ml) and severe (more than 2000 ml).
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Consolidated guidelines for the prevention, diagnosis and treatment ...
Oct 5, 2025 · Consolidated guidelines for the prevention, diagnosis and treatment of postpartum haemorrhage. 5 October 2025. | Guideline. Consolidated ...
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Quantitative Blood Loss in Obstetric Hemorrhage - ACOG
Postpartum hemorrhage resulting from uterine atony after vaginal delivery: factors associated with severity. Pithagore6 Group. Obstet Gynecol 2011; 117: 21– 31.Recommendations And... · Introduction · Prevention Of Postpartum...
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FIGO recommendations on objective measurement of blood loss ...
Sep 23, 2025 · Visual estimation of blood loss after both vaginal and cesarean birth is notoriously inaccurate and is thereby of limited clinical use. Accurate ...
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Practice Bulletin No. 183: Postpartum Hemorrhage
The purpose of this Practice Bulletin is to discuss the risk factors for postpartum hemorrhage as well as its evaluation, prevention, and management.
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Association between fibrinogen level and severity of postpartum ...
Apr 6, 2012 · The fibrinogen level at PPH diagnosis is a marker of the risk of aggravation and should serve as an alert to clinicians.
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The role of ultrasound in the diagnosis and management of ...
Feb 13, 2023 · In this article, we will review the sonographic findings occurring in PPH, in the differential diagnosis of the underlying cause of hemorrhage, ...INTRODUCTION · NORMAL THIRD STAGE OF... · USE OF ULTRASOUND IN...
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The Effectiveness of Oxytocin for Preventing Postpartum Haemorrhage
Jul 16, 2025 · Conclusions: Prophylactic oxytocin reduces the risk of PPH ≥ 500 mL and PPH ≥ 1000 mL compared to no treatment. Twenty-one percent of RCTs did ...Missing: efficacy | Show results with:efficacy
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https://pubmed.ncbi.nlm.nih.gov/24173606/
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A systematic review and meta-analyses of randomized controlled trials
Prophylactic tranexamic acid significantly reduces intraoperative blood loss and the incidence of PPH in parturients at increased risk undergoing cesarean ...
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Management of Postpartum Hemorrhage: Recommendations From ...
The most important intervention for preventing postpartum hemorrhage is administering uterotonic medications such as oxytocin between delivery of the baby and ...<|control11|><|separator|>
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https://www.nejm.org/doi/full/10.1056/NEJMoa2303966
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Intrauterine devices in the management of postpartum hemorrhage
A recent meta-analysis, including 4791 patients from 91 studies, indicated 85.9% efficacy in resolution of hemorrhage with the use of UBT devices with the ...
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Bakri Balloon Placement Technique - Medscape Reference
Dec 11, 2024 · The recommended maximum capacity of the balloon is 500 mL. In order to maximize the effect of tamponade most notable to the lower uterine ...
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Use of Bakri balloon tamponade in the treatment of postpartum ...
Aug 22, 2012 · The mean inflation volume of the balloon was 367 mL (range 30–500 mL) (data missing for three patients). In 19 cases, 500 mL of saline was used ...
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Uterine balloon tamponade for the treatment of postpartum ...
The overall pooled uterine balloon tamponade success rate was 85.9% (95% confidence interval, 83.9-87.9%). The highest success rates corresponded to uterine ...
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Temporary aortic occlusion with the abdominal tourniquet for ...
Jul 18, 2025 · Aortic compression is recommended in all major international guidelines on PPH management—including those from FIGO (the International ...
[44]
a study of a resuscitation manoeuvre for postpartum haemorrhage
External aortic compression is an emergency manoeuvre proposed to reduce postpartum haemorrhage and permit time for resuscitation and control of bleeding.
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Success Rate and Long-Term Effects of Embolization of Pelvic ... - NIH
Feb 21, 2023 · PAE was successful in 19 out of 20 women (95%) after one PAE; only 1 patient had a recurrence of hemorrhage after several days, which was ...
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Primary Postpartum Hemorrhage: Outcome of Pelvic Arterial ...
Sep 1, 2012 · In conclusion, our retrospective analysis of 251 patients with primary PPH found that PAE had a final clinical success rate of 86.5%. PAE for ...
[47]
Consolidated guidelines for the prevention, diagnosis and treatment of postpartum haemorrhage
### Summary of 2025 WHO Guidelines on Uterine Tamponade or Low-Cost Alternatives for PPH Management
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FIGO recommendations on the management of postpartum ...
Mar 17, 2022 · The purpose of this document is to update key concepts in the management of postpartum hemorrhage (PPH) and give clear and precise tools to ...FIGO RECOMMENDATIONS... · POSTPARTUM... · SHOCK INDEX EVIDENCE IN...
[49]
Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA ...
REBOA is a rapid, minimally invasive strategy for the prevention and control of postpartum haemorrhage. REBOA may reduce maternal mortality due to PPH.
[50]
Sheehan Syndrome - StatPearls - NCBI Bookshelf - NIH
Sheehan syndrome which is also called post-partum pituitary necrosis refers to the necrosis of cells of the anterior pituitary gland following significant post ...
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DIC in Pregnancy – Pathophysiology, Clinical Characteristics ...
Jan 6, 2022 · DIC in obstetrics is a life-threatening complication that is secondary to obstetrical and non-obstetrical related complications of pregnancy.
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Endometritis - StatPearls - NCBI Bookshelf - NIH
Oct 26, 2023 · Endometritis is inflammation of the uterine endometrium. Postpartum endometritis is the most common postpartum infection and should be suspected ...Introduction · Etiology · History and Physical · Differential Diagnosis
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Clinical features and outcomes of peripartum obstetric patients ...
Aug 14, 2025 · Previous studies have reported hemorrhage-related ICU admissions at rates of 11% in Australia and New Zealand, 18.8% in the United States ...
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Risk factors and recurrence of cause-specific postpartum hemorrhage
Oct 14, 2022 · To explore risk profiles of the different types of postpartum hemorrhage (PPH >500ml or severe PPH >1500ml) and their recurrence risks in a subsequent delivery.
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Recurrence of postpartum hemorrhage, maternal and paternal ...
Jan 9, 2022 · The recurrence risk of PPH was highest if the father was the same in both pregnancies, also after adjustment for the inter-delivery interval.
[56]
Current concepts in postpartum anemia management
Postpartum anemia (PPA) is common in women after childbirth and affects about 50–80% of all women worldwide. Iron deficiency (ID) is the main cause for ...
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Heavy bleeding after birth (postpartum haemorrhage) - RCOG
It is normal to bleed after you have a baby. · Women at high risk of haemorrhage will be advised to have their baby in a hospital setting. · Sometimes bleeding is ...
[58]
Consolidated guidelines for the prevention, diagnosis and treatment of postpartum haemorrhage
Official guidelines published by FIGO and WHO on October 5, 2025, providing updated criteria for identifying and managing postpartum hemorrhage, including blood loss thresholds and hemodynamic signs.
[59]
E-MOTIVE: A Bundle Intervention to Improve Detection and Treatment of Postpartum Hemorrhage
The original 2023 NEJM study evaluating the E-MOTIVE intervention, a bundle for early detection and treatment of postpartum hemorrhage using a calibrated drape and subsequent steps, demonstrating a 60% reduction in severe PPH risks.