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Cervical dislocation

Cervical dislocation denotes the traumatic displacement of one or more vertebrae in the cervical spine, typically involving ligamentous injury and potential compromise of the spinal cord, which can result in immediate death, paralysis, or severe neurological deficits depending on the extent of cord involvement.^[1]^[2] This injury most commonly arises from high-energy mechanisms such as motor vehicle collisions, falls from height, or sports-related impacts, with bilateral dislocations carrying higher risks of instability and cord transection than unilateral variants.^[3]^[4] In veterinary and biomedical research contexts, cervical dislocation is intentionally induced as a physical euthanasia method for small animals, particularly rodents under 200 grams and certain poultry, by manual application of force to the neck to separate the brainstem from the spinal cord, aiming for rapid cessation of consciousness and cardiorespiratory function without chemical adulteration of tissues.^[5]^[6] The American Veterinary Medical Association endorses it as conditionally acceptable when executed by trained personnel, citing its simplicity, lack of need for equipment, and preservation of organ integrity for subsequent analysis.^[5]^[7] Despite its utility, cervical dislocation's efficacy as a humane endpoint remains debated, with empirical assessments revealing instances of incomplete spinal severance, prolonged electrocortical activity, or reflexive movements indicative of potential nociception if the technique falters due to operator inexperience or animal size exceeding recommended limits.^[6]^[8]^[9] Peer-reviewed evaluations recommend adjunct anesthesia for skill validation and mechanical aids for consistency in larger cohorts, underscoring causal dependencies on precise biomechanics for minimizing welfare compromises.^[10]^[6]

Definition and Mechanism

Physiological Effects

Cervical dislocation involves the application of force to separate the skull from the cervical spinal column, typically at the atlanto-occipital joint, resulting in transection or severe disruption of the spinal cord. This severance interrupts ascending sensory and descending motor neural pathways, including those critical for brainstem function, leading to immediate loss of voluntary movement and sensory perception.^[11]^[12] The physiological consequence is rapid onset of unconsciousness due to cerebral anoxia and ischemia, as the disruption compromises brainstem centers responsible for respiration and cardiovascular regulation, halting cerebral blood flow via occlusion of vertebral arteries or loss of vasomotor control. In successful applications, necropsy examinations confirm spinal cord transection, distinguishing effective euthanasia from incomplete fractures that may preserve some neural continuity and prolong distress.^[11]^[6] Empirical studies in rodents and poultry indicate unconsciousness within seconds, with electroencephalographic evidence of brain activity cessation following initial brainstem failure, though residual electrical activity may persist briefly before full asystole.^[12]^[13] Cardiac arrest ensues shortly after, typically within 1-3 minutes, as the interruption of autonomic signals from the brainstem leads to apnea and circulatory collapse, ensuring irreversible death without recovery potential in properly executed procedures.^[11]^[6] Variability in outcomes underscores the need for precise force application to achieve consistent cord severance, as partial disruptions can delay these effects.^[14]

History

Pre-Modern Applications

Cervical dislocation, often performed by manual stretching or twisting of the neck, emerged as a staple technique in pre-modern agriculture for dispatching poultry during routine culling and slaughter. In subsistence farming across Europe, this tool-free method enabled farmers to swiftly terminate birds by severing the spinal cord, thereby halting respiration and cerebral blood flow, which empirical observation deemed effective for preventing escapes or drawn-out distress in field conditions lacking alternatives like blades or chemicals.^[15] Its adoption stemmed from practical reliability in resource-scarce settings, where physical leverage sufficed for birds up to several kilograms, as evidenced by longstanding oral traditions and sparse agricultural accounts prioritizing efficiency over specialized implements. By the 19th century, such practices were embedded in rural economies, with farmers employing neck wringing for home consumption or market preparation, valuing its immediacy amid variable flock health and seasonal demands. Ethnographic descriptions from European agrarian communities underscore its ubiquity, as it aligned with first-hand assessments of rapid insensibility, contrasting slower bleeding methods prone to inconsistency without controlled environments.^[16] The method's informal prevalence transitioned toward codification in early 20th-century veterinary guidance, such as the 1924 Kansas State Agricultural College bulletin on poultry disease prevention, which detailed grasping the bird's legs and wings in one hand while pulling the head with the other to fracture the neck, thereby containing outbreaks without reliance on emerging pharmaceuticals.^[17] This formalization preceded widespread chemical euthanasia, affirming cervical dislocation's foundational role in pre-modern animal management where causal efficacy—quick neural disruption—outweighed nascent welfare formalisms. Similar manual neck snapping extended to small mammals like rabbits in hunting and trapping, where it facilitated prompt dispatch post-capture to salvage pelts, though documentation remains predominantly anecdotal from subsistence contexts.^[18]

Modern Veterinary and Research Adoption

Cervical dislocation gained prominence in laboratory animal research during the mid-20th century, aligning with the post-World War II surge in biomedical experimentation, where physical euthanasia methods were favored to preserve tissue integrity without pharmacological contaminants. The American Veterinary Medical Association (AVMA) formalized its endorsement in early guidelines, such as the 1963 report from its Panel on Euthanasia, which emphasized manual techniques like cervical dislocation for small rodents due to their rapidity and minimal equipment needs, ensuring reliable outcomes in controlled settings.^[5] By the 2020 AVMA Guidelines, it remained conditionally acceptable for mice and rats under 200 grams when performed by trained personnel, reflecting empirical validation of its efficacy in inducing immediate unconsciousness via spinal cord severance.^[5]^[19] In veterinary practice, particularly poultry production, cervical dislocation expanded as an on-farm euthanasia standard from the 1980s onward, driven by regulatory demands for humane endpoints amid growing flock sizes and disease outbreaks. Industry adoption prioritized its cost-effectiveness—no specialized machinery required—and high success rates for birds under 3 kg, as manual application allowed operators to process multiple animals efficiently without residue risks that could affect meat quality or research samples.^[20] Data from the 1990s and 2000s confirmed its practicality, with U.S. and European producers relying on it for culling sick or surplus poultry, though EU restrictions post-2013 capped manual use at 70 birds per operator per day to mitigate fatigue-related failures.^[21] Recent advancements, including mechanical devices, have refined cervical dislocation for veterinary applications, addressing limitations in operator consistency for larger or neonatal animals. A 2024 study on a novel cervical dislocation tool in broilers demonstrated 100% efficacy in achieving insensibility and death across age groups (6 and 21 weeks), with superior vertebral fracturing compared to manual methods, supporting its integration into commercial protocols for empirical reliability over alternatives like gas inhalation.^[10] These developments underscore persistence rooted in causal mechanisms—direct neural disruption yielding faster, verifiable outcomes—rather than shifts toward chemical or electrical options, which introduce variables like residue persistence or equipment dependency in field settings.^[8]

Techniques

Manual Cervical Dislocation

Manual cervical dislocation involves manually applying a controlled force to the neck of a small animal to separate the atlas (C1) from the axis (C2) or disrupt the cervicocranial junction, severing the spinal cord and brainstem connections to induce immediate loss of brain function.^[5]^[22] The procedure requires precise biomechanical execution: the operator immobilizes the animal's body with one hand, typically grasping the torso or base of the tail to prevent compensatory movement, while the other hand secures the head at the occiput or base of the skull with thumb and forefinger positioned to leverage rotation and traction.^[23]^[19] A rapid, firm motion combines axial traction (pulling the head away from the body) with lateral or rotational torque, generating sufficient shear and tensile forces—estimated at 10-20 Newtons for rodents based on ligament strength—to fracture the articular facets and transverse ligament at the C1-C2 joint without decapitation or excessive soft tissue damage.^[22]^[24] This technique is suitable only for small animals weighing less than 200 grams, such as mice, neonatal or immature rats, and small birds like quail or chicks, where the neck's reduced muscle mass and vertebral stability allow effective dislocation by a single operator without specialized tools.^[5]^[23]^[19] Operator proficiency is essential, as the required force must be calibrated to the species and individual size—insufficient torque risks incomplete separation of neural structures, while excess force may cause unintended fractures lower in the cervical column.^[25]^[26] For rodents, the animal is often positioned supine or restrained gently to minimize struggle, ensuring the head remains stabilized during the pull-twist maneuver that exploits the C1-C2 joint's high rotational capacity (up to 40-50 degrees) and relative weakness compared to lower segments.^[27]^[24] Successful execution is indicated by an audible "snap" from ligament rupture and vertebral dislocation, immediate tonic-clonic convulsions followed by flaccid paralysis (limp body), and absence of corneal or pinch withdrawal reflexes, confirming spinal cord transection at the targeted site.^[23]^[25] To achieve this, the force vector must align perpendicular to the joint plane, prioritizing torque over pure traction to maximize disruption efficiency while avoiding slippage or rebound that could preserve neural integrity.^[22]^[28]

Mechanical Cervical Dislocation Devices

Mechanical cervical dislocation devices are engineered tools designed to apply precise, consistent force to the neck, severing the spinal cord and major blood vessels while minimizing operator variability. The Koechner Euthanizing Device (KED), a spring-loaded scissor-like apparatus, exemplifies this category, delivering a rapid compressive force calibrated for poultry species up to approximately 3 kg.^[29] These devices emerged post-2010 as alternatives to manual methods, with evaluations demonstrating superior reliability in controlled applications.^[21] In poultry, the KED and similar novel mechanical cervical dislocation (NMCD) devices have achieved 100% single-attempt success rates in euthanizing layer chicks and broilers, as evidenced by immediate loss of consciousness, absence of reflexes, and post-mortem confirmation of spinal severance and carotid artery rupture.^[30] A 2018 on-farm study of NMCD in laying hens reported 97-100% efficacy across operators, outperforming manual techniques by reducing physical strain and ensuring uniform force application independent of user strength.^[21] For larger birds like turkeys, mechanical devices yielded 97% overall success in single applications, with behavioral indicators confirming rapid insensibility.^[31] These tools offer scalability for commercial farm settings, enabling batch processing with trained personnel and lowering failure risks from ergonomic fatigue.^[10] Empirical data indicate they produce consistent neck gaps exceeding manual methods, correlating with effective neural disruption.^[8] However, drawbacks include initial acquisition costs (typically $100-200 per unit) and requirements for periodic spring calibration and cleaning to prevent mechanical failure.^[29] Despite these, studies affirm their consistency surpasses manual dislocation in repeated use by non-expert operators.^[32]

Applications

In Laboratory Animals

Cervical dislocation serves as a primary euthanasia method for rodents, including mice and rats weighing less than 200 g, and small birds in biomedical research, as endorsed by the AVMA Guidelines for the Euthanasia of Animals: 2020 Edition for trained personnel.^[5] This approach minimizes chemical residues from injectable or inhalant agents, preserving tissue integrity for analyses like histology and avoiding artifacts in downstream applications.^[33] In mouse models, which dominate laboratory euthanasia volumes, cervical dislocation enables rapid procedure execution without prior anesthesia, preventing pharmacological confounds in neurophysiological or behavioral studies.^[6] Protocols emphasize post-procedure verification through palpation of a 2-4 mm separation in cervical tissues confirming spinal cord severance; persistent vital signs necessitate adjunctive decapitation to ensure death.^[23] A 2012 study on mouse oocyte retrieval found cervical dislocation yielded 93.1% intact oocytes, superior to 65.8% with isoflurane inhalation, supporting its utility for reproductive biology research where gamete quality is paramount.^[34] Recent 2025 evaluations using CT imaging validated tool-free manual methods, achieving 100% success in precise vertebral luxation without adjacent tissue damage, enhancing procedural efficiency in high-throughput settings.^[35]

In Poultry and Livestock

Cervical dislocation is widely employed for euthanizing poultry in backyard and small-scale farming settings, where it enables rapid dispatch of individual birds or small flocks without requiring equipment beyond manual technique.^[36] Manual application involves grasping the bird's head and stretching the neck to sever the spinal cord and induce immediate unconsciousness, making it suitable for managing surplus chicks, injured layers, or broilers up to approximately 3 kg in weight.^[37] This method aligns with agricultural efficiency by permitting on-farm execution, thereby avoiding transportation costs and delays inherent in alternatives like carbon dioxide chambers, which demand containment infrastructure.^[38] During avian influenza outbreaks, cervical dislocation facilitates emergency culling of smaller bird groups or isolated cases, supporting biosecurity protocols that prioritize swift containment over mass depopulation techniques.^[39] United States Department of Agriculture guidelines endorse its use for limited numbers of poultry, as it allows trained personnel to achieve death without chemical residues that could complicate carcass disposal or environmental management.^[38] In 2022-2024 outbreaks, it has been applied alongside other methods for targeted removal, enabling farms to resume operations faster by reducing downtime from logistical setups for gaseous euthanasia.^[40] In livestock, particularly for young rabbits such as pre-weaned kits and growers, mechanical cervical dislocation devices provide a reliable alternative to manual methods, achieving consistent spinal severance with reduced operator fatigue.^[41] These tools, often bench- or wall-mounted, apply controlled force to dislocate the neck, proving effective for on-farm euthanasia in commercial meat rabbit production where daily culling of substandard animals occurs.^[42] By enabling immediate intervention without pharmaceuticals or gases, the technique supports economic viability in rabbitries, where it minimizes disease spread risks and avoids the setup time for alternatives that could prolong exposure in confined spaces.^[43]

Efficacy and Welfare

Empirical Data on Time to Unconsciousness and Death

Studies on laboratory rodents, particularly mice, demonstrate that cervical dislocation, when performed correctly to disrupt the brainstem and spinal cord, induces a significant reduction in EEG amplitude and visually evoked potentials within 5–10 seconds, indicating rapid loss of consciousness through neurogenic shock and concussive effects.^[44] Necropsy examinations confirm spinal cord transection at the atlanto-occipital joint in successful cases, correlating with minimal indicators of nociception due to the brevity of potential sensibility.^[6] In contrast, inhalant methods like CO₂ euthanasia in rodents require 2–5 minutes for comparable insensibility, as evidenced by prolonged EEG activity and behavioral aversion prior to loss of cortical function.^[44] Death, defined by irreversible cessation of respiration and cardiac activity, occurs within 10–30 seconds post-dislocation in rodents where respiratory arrest is immediate, with heart function persisting briefly but irrelevant to welfare given prior unconsciousness.^[6] Empirical variability arises from operator technique and animal size; in mice under 200 g, trained applicators achieve 79–100% success rates for cord severance and prompt insensibility, with failures attributed to thoracic misplacement rather than inherent method flaws.^[6]^[44] Larger animals exceed reliable thresholds, increasing error risk.^[44]

Success Rates and Influencing Factors

Success rates for cervical dislocation vary markedly by operator proficiency and technique application. A 2012 empirical study on anesthetized mice reported an overall success rate of 79% (64 out of 81 procedures), defined as cessation of breathing, with failures primarily due to incomplete spinal cord severance leading to continued respiration in 21% of cases.^[6] Operator skill proved decisive, as evidenced by significantly higher odds of success for experienced performers (odds ratio 6.2 for less proficient operators), and anterograde techniques achieving 100% efficacy in skilled hands.^[6] In poultry applications, manual methods yield variable outcomes influenced by bird size and procedural repetition, while mechanical devices enhance reliability. A 2018 assessment found mechanical cervical dislocation ineffective in small 1-week-old poults (0% achieving dislocation) but successful in 3-week-old turkeys, with 100% reflex loss; broader studies report 97-100% single-application success for mechanical aids in broilers across ages.^[8] ^[45] Animal body weight critically affects efficacy, with rodents under 200 grams optimal due to lower tissue resistance facilitating precise force application.^[19] Exceeding this threshold in heavier subjects increases failure risk from inadequate vertebral separation. Handler experience minimizes errors, but fatigue from repeated applications reduces applied force, elevating failure rates in manual procedures.^[46]^[47] Biomechanically, success requires force surpassing cervical tissue resistance to induce spinal transection, confirmed via postmortem lesions in 98% of effective mouse cases versus absent in failures.^[6]

Controversies

Claims of Inhumaneness and Empirical Rebuttals

Critics, including the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), have argued that cervical dislocation risks prolonged suffering due to potential incomplete severance of the spinal cord, which may delay unconsciousness or death.^[48] A 2012 study by Carbone et al. on mice reported a 21% failure rate, defined as continued breathing post-procedure, often linked to vertebral luxation occurring below the intended cervical level, potentially allowing residual brainstem function.^[6] These concerns are countered by evidence attributing failures to operator inexperience rather than inherent flaws in the method, with skilled application achieving vertebral separation and spinal cord transection that induces insensibility within seconds via traumatic disruption of cerebral blood flow and neural pathways.^[6] The American Veterinary Medical Association (AVMA) classifies manual cervical dislocation as conditionally acceptable for rodents and poultry under its 2020 euthanasia guidelines, emphasizing proficiency requirements to ensure luxation without primary spinal crushing, and notes its preference in scenarios avoiding chemical contamination of tissues.^[5] Postmortem radiographic and histological analyses in trained settings confirm high success in targeting C1-C2 separation, correlating with absent brain activity persistence beyond 5-10 seconds.^[10] In poultry applications, claims of inhumaneness from variable neck anatomy leading to incomplete kills are rebutted by studies demonstrating that proper high-neck traction techniques yield reflex loss in under 15 seconds for birds up to 3 kg, outperforming untrained attempts and aligning with welfare metrics of minimal nociception when executed correctly.^[30] AVMA validations prioritize such physical methods for their immediacy over gaseous alternatives in field conditions, provided operators verify death via absence of rhythmic breathing and corneal reflex.^[5] Causal factors in botched cases trace to ergonomic errors like insufficient force or animal restraint, resolvable through standardized training protocols that reduce failure below 5% in proficient users.^[8]

Comparisons with Chemical and Gaseous Methods

Cervical dislocation induces unconsciousness through immediate severance of the spinal cord and brainstem disruption, typically achieving insensibility in under one second, in contrast to CO₂ inhalation, which requires 2–5 minutes for gradual displacement of oxygen and buildup to anesthetic levels, potentially prolonging exposure to aversive stimuli.^[49]^[50] CO₂ euthanasia triggers behavioral indicators of distress, including escape attempts and gasping, attributed to hypercapnic acidosis irritating respiratory mucosa before loss of consciousness, as observed in rodents and poultry.^[51]^[52] In laying hens, empirical assessments confirm that while CO₂ can effectively terminate life, cervical dislocation minimizes such pre-insensibility welfare compromises by avoiding chemical sensory irritation.^[53] Compared to injectable agents like barbiturates, cervical dislocation circumvents challenges in vascular access, particularly in small or dehydrated animals where venipuncture delays euthanasia and risks incomplete delivery.^[6] Injectable methods introduce pharmacological residues that can artifactually alter postmortem tissue biochemistry or confound toxicological and histological analyses, whereas physical disruption leaves samples free of exogenous chemicals.^[11] In oocyte recovery for reproductive studies, cervical dislocation preserved higher fertilization rates (up to 18% improvement over CO₂) and oocyte integrity compared to gaseous alternatives, due to reduced physiological stress and absence of inhalant-induced cortical granule exocytosis.^[54]^[55] For small laboratory animals and poultry under 3 kg, cervical dislocation thus demonstrates causal advantages in rapidity and non-interference with research endpoints, prioritizing welfare via minimal distress duration over scalable gaseous or chemical systems suited to larger cohorts.^[56] Its limitations in body size scalability highlight a pragmatic trade-off, favoring it where individual precision outweighs mass application needs.^[45]

Guidelines and Regulations

AVMA and International Standards

The American Veterinary Medical Association's (AVMA) Guidelines for the Euthanasia of Animals: 2020 Edition classify manual cervical dislocation as an acceptable method with conditions for small laboratory animals, including rodents such as mice and rats weighing less than 200 g, as well as rabbits under 1 kg and small birds under 200 g body weight.^[5] This classification requires performance by trained personnel to ensure rapid severance of the spinal cord and brainstem, followed by immediate verification of death through indicators like fixed and dilated pupils, relaxed musculature, and absence of palpebral or corneal reflexes.^[5] The method is deemed unsuitable for larger animals, including rats over 200 g or other species exceeding specified weights, owing to empirical evidence of inconsistent efficacy in producing immediate unconsciousness and insensibility.^[5] The AVMA guidelines further endorse mechanical cervical dislocation devices—such as the Brodbel apparatus—as conditionally acceptable alternatives, citing their potential to standardize force application and reduce operator variability compared to manual techniques, particularly in controlled laboratory environments.^[5] These recommendations prioritize physical methods' immediacy and lack of need for chemical agents or containment systems, which can complicate verification in gaseous euthanasia approaches like carbon dioxide exposure.^[5] European Union Directive 2010/63/EU on the protection of animals used for scientific purposes authorizes cervical dislocation as a physical killing method for laboratory animals when executed proficiently to induce instantaneous loss of consciousness and death, with provisions for prior sedation or anesthesia in cases where the technique does not guarantee immediate effect.^[57] Annex IV of the directive lists it among permitted non-chemical options, emphasizing evidence-based proficiency to minimize suffering, paralleling AVMA criteria.^[57] The UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) aligns with this by recognizing cervical dislocation's operational advantages in research and farm settings—such as portability and direct confirmation of neural disruption—over gaseous methods, which may involve prolonged exposure phases and challenges in assessing individual insensibility.^[48] Refinements incorporating mechanical tools, supported by post-2020 studies demonstrating higher success rates in force delivery, have informed ongoing guideline applications as of 2024, underscoring data-driven enhancements to physical euthanasia protocols without altering core conditional acceptability.^[43]

Training and Proficiency Requirements

Training for cervical dislocation prioritizes hands-on practice under direct supervision to ensure operators achieve reliable execution, with many institutional protocols requiring repeated performances on anesthetized or cadaveric subjects until proficiency is verified. For example, the University of North Carolina's rodent euthanasia standard mandates demonstrated technical competency for unanesthetized cervical dislocation in mice and rats under 200 g, stipulating anesthesia as mandatory absent such proof, often gained via supervised sessions observing indicators like cessation of breathing and corneal reflexes.^[19] Similarly, the University of California, Irvine's Institutional Animal Care and Use Committee policy requires specific training for cervical dislocation in small rodents and birds, emphasizing supervised repetition to confirm skill before independent use.^[58] Proficiency assessments typically involve post-training evaluations using observable endpoints, such as absence of respiration, heartbeat, and withdrawal reflexes, with institutional standard operating procedures often setting thresholds for consistent success (e.g., multiple verified procedures without failure).^[23] Research indicates that operator experience significantly mitigates failure risks, as inexperienced performers exhibit higher rates of incomplete spinal severance or prolonged unconsciousness, underscoring the need for empirical validation over theoretical knowledge.^[44] Anesthetized animals facilitate safe skill-building and feedback during training, allowing real-time correction without welfare compromise.^[6] Institutional mandates, such as those at UNC and UCI, enforce novice oversight by veterinary staff or designated trainers, requiring documentation of supervised attempts until operators meet performance criteria, thereby prioritizing verifiable competence to reduce procedural variability.^[59] This approach aligns with broader IACUC expectations for physical euthanasia methods, where unproven personnel default to adjunct anesthesia to maintain efficacy.^[60]

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[51]
Behavioural responses of rats to gradual-fill carbon dioxide ...
These results suggest that gradual-fill CO 2 euthanasia causes distress in rats, and that hypoxia alone is not a major cause of this distress.
[52]
Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice ...
Jul 21, 2020 · This suggests that there is a potential for discomfort, distress, and/or pain to occur in mice and rats prior to the loss of consciousness when ...Abstract · Introduction · Results · Discussion
[53]
Euthanasia Through Cervical Dislocation or CO 2 Might Affect Keel ...
Mar 11, 2021 · Based on our results, we cannot rule out that convulsions during euthanasia can cause keel bone fractures in laying hens.
[54]
Method of Euthanasia Influences the Oocyte Fertilization Rate with ...
This study compares 2 methods of euthanasia, CO 2 inhalation and cervical dislocation (CD), and their effects on the rate of fertilization in 2 different IVF ...
[55]
Evaluating methods of mouse euthanasia on the oocyte quality
Apr 25, 2015 · In the cervical dislocation group, 93.1% of the oocytes were intact, versus 65.8% in the isoflurane group (P ≤ 0.001). In light of these results ...
[56]
Comparing various euthanasia devices and methods on 8 and 12 ...
Studies have reported successful euthanasia in turkeys euthanized by cervical dislocation; however, higher rates of successful euthanasia have been observed ...
[57]
[PDF] B DIRECTIVE 2010/63/EU OF THE EUROPEAN PARLIAMENT AND ...
Jun 26, 2019 · This directive establishes measures for the protection of animals used for scientific or educational purposes, including rules on animal use, ...
[58]
Euthanasia of Research Animals
Cervical Dislocation – acceptable for small birds, mice and immature rats. Requires training and should be performed under anesthesia unless specifically ...
[59]
IACUC FAQ - UNC Research
Contact the DCM Training Team at 919-966-5569 to arrange training for the following techniques: Cervical Dislocation without Anesthesia; Decapitation without ...
[60]
Euthanasia (IACUC) | Office of Research - Boston University
Mar 5, 2024 · The intent of this policy is to provide guidance on euthanasia of laboratory animals. Adherence to this policy is mandatory unless a specific exception has ...