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DRACO

DRACO (Double-stranded RNA Activated Caspase Oligomerizer) is an experimental class of broad-spectrum antiviral therapeutics developed by Todd Rider at the Massachusetts Institute of Technology (MIT). First described in 2011, DRACO works by detecting double-stranded RNA—a byproduct of viral replication in infected cells—and triggering apoptosis (programmed cell death) specifically in those cells, sparing healthy ones.^[1]^[2] The technology showed promise in preclinical studies, demonstrating efficacy against 15 viruses in cell cultures, including dengue, H1N1 influenza, and poliovirus, and improving survival rates in mice infected with H1N1.^[2] Lacking traditional funding, Rider launched a crowdfunding campaign in 2015 to advance testing.^[3] Development continued at Draper Laboratory before transitioning to Kimer Med, a New Zealand-based company, which has refined the approach into the VTose platform.^[4] As of 2025, Kimer Med reports VTose success against 10 viruses, including all four dengue serotypes, Zika, and rhinovirus, with 100% efficacy in lab tests against dengue (DENV-2) and Zika (ZIKV) as of June 2023. The company signed a contract with Battelle Memorial Institute in 2024 (valued up to USD$750,000) for alphavirus antivirals, with ongoing progress toward clinical trials.^[5]^[6] DRACO's potential lies in treating diverse viral infections, including emerging pandemics, though challenges remain in delivery, specificity, and human trials.

Overview

Definition and Background

DRACO, or Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer, is an experimental broad-spectrum antiviral drug candidate designed to target a wide array of viral infections by inducing programmed cell death in infected cells.^[2] Developed by bioengineer Todd Rider at the Massachusetts Institute of Technology (MIT), the concept emerged in the early 2000s as part of efforts to address the limitations of traditional antivirals, which are typically effective only against specific viruses and fail against emerging or diverse pathogens.^[1] Rider's innovation draws from the observation that many viruses produce dsRNA as a byproduct of replication, a molecular signature absent in healthy human cells, allowing for selective therapeutic action.^[2] The foundational work on DRACO was first detailed in a 2011 publication in PLOS ONE, where Rider and colleagues described the chimeric protein's ability to detect viral dsRNA and trigger apoptosis, thereby sparing uninfected cells and potentially treating numerous viral diseases with a single agent.^[2] This approach was inspired by the urgent need for versatile antivirals in an era of frequent viral outbreaks, where virus-specific drugs like those for HIV or influenza offer limited prophylaxis against novel threats such as dengue or hantavirus.^[1] By focusing on a universal viral hallmark rather than individual pathogen traits, DRACO represents a paradigm shift toward pan-viral therapies, though it remains in preclinical stages without clinical approval. As of 2025, derivatives such as Kimer Med's VTose platform continue development based on the original DRACO approach.^[7]

Significance and Potential Impact

The current landscape of antiviral therapies is dominated by drugs that target specific viruses, such as antiretrovirals for HIV or nucleoside analogs for hepatitis B and C, leaving the vast majority of human viral pathogens without effective treatments.^[8] Approximately 270 virus species (as of 2022) are known to infect humans, yet approved antivirals exist for only a small fraction of these, rendering more than 200 viral diseases—ranging from common colds to severe hemorrhagic fevers—largely unmanaged through pharmacology.^[9]^[1] DRACO addresses this gap by pursuing pan-viral efficacy, exploiting a universal feature of viral replication (double-stranded RNA intermediates) to induce selective apoptosis in infected cells, potentially offering a single therapeutic platform against diverse RNA and DNA viruses. DRACO's broad-spectrum potential holds particular promise for combating emerging viral threats, including pandemics like COVID-19 or Ebola, as well as endemic infections such as the common cold caused by rhinoviruses.^[1] By targeting viral dsRNA rather than virus-specific proteins, DRACO could enable rapid deployment against novel pathogens without the delays inherent in developing tailored drugs, which often take years and billions in investment per virus. This approach contrasts sharply with narrow-spectrum antivirals, potentially slashing development timelines and costs while minimizing the risk of viral escape through mutation.^[10] A key advantage of DRACO is its selectivity, activating only in virally infected cells via dsRNA binding, thereby sparing uninfected host cells and reducing toxicity—a common limitation of existing broad-acting agents like interferons. On the public health front, DRACO could facilitate prophylaxis and treatment for "orphan" viruses lacking commercial incentives for drug development, such as many neglected tropical viruses, ultimately alleviating the enormous economic toll of viral infections.^[1] Viral diseases impose an annual global economic burden exceeding $200 billion in lost productivity and healthcare costs from zoonotic outbreaks alone, with broader impacts—including routine illnesses like influenza and respiratory syncytial virus—pushing totals far higher and underscoring the transformative potential of pan-viral therapies.^[11]

Development History

Initial Discovery at MIT

The initial discovery of DRACO (Double-stranded RNA Activated Caspase Oligomerizer) occurred at the Massachusetts Institute of Technology's Lincoln Laboratory, where senior staff scientist Todd H. Rider led the research effort as the primary inventor and designer of the therapeutic approach.^[1]^[2] Rider, drawing from his prior invention of the CANARY biosensor for rapid pathogen detection, conceptualized a broad-spectrum antiviral strategy in the early 2000s to address the limitations of virus-specific treatments by targeting a common feature of viral replication.^[1] Development progressed through the design and testing of initial DRACO prototypes, culminating in proof-of-concept demonstrations by 2011. The foundational publication, "Broad-Spectrum Antiviral Therapeutics," appeared in PLoS ONE on July 27, 2011, marking the first experimental evidence that DRACOs could selectively induce apoptosis in virus-infected cells via recognition of double-stranded RNA, a hallmark of many viral infections, while sparing healthy cells.^[2] This work was supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID, grant AI057159) and the New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, with earlier phases bolstered by funding from the Defense Advanced Research Projects Agency (DARPA) aimed at biodefense applications.^[2]^[1] In cell culture experiments detailed in the 2011 paper, DRACOs demonstrated efficacy against 15 diverse viruses, including dengue flavivirus, H1N1 influenza A virus, and poliovirus, by reducing viral titers with half-maximal effective concentrations (EC₅₀) typically in the 2–3 nM range.^[2] The constructs showed no cytotoxicity across 11 mammalian cell types at concentrations up to 10 times the EC₅₀, establishing their selective targeting potential without harming uninfected cells.^[2] These results highlighted DRACO's core design as a fusion protein linking dsRNA-binding domains to apoptosis-inducing signals, offering a novel paradigm for antiviral intervention.^[2]

Progression at Draper Laboratory

In January 2014, the DRACO research program transitioned from MIT Lincoln Laboratory to Draper Laboratory, an independent nonprofit engineering organization originally spun off from MIT in 1970, where inventor Todd Rider joined as senior technical staff to advance the project's development. This move enabled more focused efforts on optimization and preclinical scaling, building on the foundational in vitro and in vivo demonstrations from MIT.^[12] At Draper, key research activities centered on refining DRACO's formulation for improved efficacy and safety, including enhancements to delivery mechanisms such as cell-penetrating peptides to facilitate better cellular uptake, alongside expanded testing against additional viral strains in both cell cultures and animal models. These efforts aimed to address limitations in broad-spectrum applicability and prepare for potential larger-scale trials, with initial results indicating sustained antiviral activity without significant toxicity.^[12] In 2015, independent validation of DRACO's potential came from a study demonstrating its robust inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication in vitro, including in porcine alveolar macrophages, by suppressing viral RNA and protein synthesis while modulating innate immune responses like IL-6 induction. This work, conducted by researchers unaffiliated with Draper, confirmed DRACO's activity against a economically significant agricultural pathogen, supporting its broad-spectrum promise beyond initial targets.^[13] However, the program faced growing challenges in scaling from proof-of-concept to clinical viability, including complexities in manufacturing larger quantities and navigating regulatory hurdles for broad antiviral agents. These issues were compounded by shifting institutional priorities at Draper, leading to Rider's departure in May 2015 after two years of leadership on the project.^[3]^[14] Research effectively paused by December 2015 following the exhaustion of available funding, as continued support from initial backers like DARPA did not materialize for the advanced phases at Draper, marking the end of institutional development efforts.^[3]

Post-2015 Efforts and Crowdfunding

Following his departure from Draper Laboratory in May 2015, Todd Rider founded the RIDER Institute later that year to independently advance DRACO development outside institutional constraints.^[3]^[14] In May 2016, the RIDER Institute launched an Indiegogo crowdfunding campaign seeking $2 million to produce, test, and optimize DRACOs specifically against herpesviruses, including major pathogens like herpes simplex virus types 1 and 2, cytomegalovirus, and Epstein-Barr virus; the effort garnered publicity but failed to reach its funding goal, limiting subsequent progress.^[15] A prior 2015 Indiegogo campaign led by Rider had raised approximately $60,000 toward initial DRACO optimization against clinically relevant viruses, building on early MIT cell culture tests showing broad efficacy.^[16] In 2020, an independent study accepted for publication confirmed DRACO's efficacy against H1N1 influenza in Madin-Darby canine kidney (MDCK) cell cultures, demonstrating dose-dependent viral inhibition at concentrations of 40–80 mg/L while remaining nontoxic to uninfected cells, with significant reductions in tissue culture infectious dose 50 (TCID50) compared to controls.^[17] Rider's foundational patents from MIT, including US Patent 7,566,694 for anti-pathogen treatments incorporating pathogen-detection and effector domains, were licensed in 2020 to Kimer Med, a New Zealand-based biotech company founded to develop DRACO-derived antivirals, enabling commercial progression of the technology.^[18]^[19] This transition addressed persistent funding challenges for independent research, with further details on derivatives and updates covered in subsequent sections.

Mechanism of Action

Core Molecular Design

DRACO is engineered as a chimeric protein that fuses the double-stranded RNA (dsRNA)-binding domain of protein kinase R (PKR) with the death domain of apoptotic protease activating factor 1 (APAF1), creating a molecular sensor-effector capable of detecting viral infection and initiating targeted cell death. Specifically, the design incorporates the N-terminal dsRNA-binding region of PKR (amino acids 1–181), which serves as the detection module, linked to the caspase recruitment domain (CARD) of APAF1 (amino acids 1–97), which functions as the apoptotic effector. This fusion allows DRACO to mimic and amplify natural antiviral and apoptotic pathways without relying on the full-length proteins, enabling a compact structure suitable for therapeutic delivery.^[10] The PKR domain in DRACO specifically binds to viral dsRNA intermediates longer than 30 base pairs, a hallmark of many viral replication cycles that is typically absent in healthy mammalian cells. Upon binding, multiple DRACO molecules cross-link on the dsRNA scaffold, leading to their oligomerization and activation. This binding threshold ensures selectivity for infected cells, as short, endogenous dsRNA species in uninfected cells do not trigger the response. The design leverages PKR's natural affinity for dsRNA to initiate the downstream cascade without requiring phosphorylation, simplifying the activation process compared to native PKR signaling.^[10] Once oligomerized, the APAF1 CARD domain recruits and activates caspase-9, forming an apoptosome-like complex that propagates the apoptosis pathway, resulting in the programmed death of the infected cell. This qualitative oligomerization process, driven by multivalent dsRNA binding, amplifies the signal to ensure efficient effector recruitment. For cellular delivery, DRACO is conjugated to cell-penetrating peptides such as the TAT peptide (sequence: YGRKKRRQRRR), which facilitates uptake across cell membranes without the need for viral vectors or lipid formulations. This conjugation enhances transduction efficiency, allowing DRACO to reach intracellular targets effectively.^[10] To improve performance, DRACO variants have been optimized for protein stability and delivery efficacy, including modifications like N-terminal epitope tags and alternative linker configurations. Examples include constructs such as NTE3L (with an N-terminal tag and E3L-inspired binding enhancements) and CTE3L (C-terminal tag variant), as well as fusions incorporating tandem dsRNA-binding domains (e.g., 2×E3L) or the RNase L effector domain (amino acids 1–335) for alternative apoptotic signaling. These optimizations balance binding specificity, solubility, and cellular penetration while maintaining the core detection-effector architecture.^[10]

Selective Targeting of Infected Cells

DRACO achieves selective targeting of virus-infected cells by exploiting a key molecular hallmark of viral replication: the production of long double-stranded RNA (dsRNA) intermediates. Many viruses generate dsRNA helices exceeding 21–23 base pairs during their transcription and replication cycles, a feature rarely present in uninfected mammalian cells, which typically produce only short, non-immunogenic dsRNA species.^[20] This dsRNA serves as a specific biomarker for infection, allowing DRACO to bind selectively without affecting healthy cells.^[20] Upon binding to dsRNA, DRACO—the fusion protein incorporating PKR and APAF1 domains—oligomerizes and activates the intrinsic apoptosis pathway in the infected cell. This activation directly recruits and activates procaspase-9, which propagates the apoptosis pathway by activating downstream effector caspases, leading to programmed cell death that executes within hours of detection.^[20] The process ensures that only dsRNA-positive cells undergo apoptosis, thereby containing the infection at its source. Selectivity has been demonstrated through extensive testing, showing no toxicity in 11 different uninfected mammalian cell lines, while effectively inducing death solely in cells transfected with synthetic dsRNA or actively infected.^[20] This targeted response minimizes off-target effects, as DRACO exhibits no apparent adverse impact on unchallenged cells even at concentrations sufficient for antiviral activity.^[20] The time course of DRACO-induced apoptosis is notably rapid, with cellular uptake occurring within 10 minutes to 1.5 hours post-administration and full execution of cell death between 2 and 24 hours following infection or dsRNA exposure.^[20] This swift timeline prevents viral dissemination by eliminating infected cells before progeny viruses can propagate widely. In contrast to traditional antivirals, such as polymerase or protease inhibitors that directly target specific viral proteins and risk resistance through mutations, DRACO leverages the host's innate response to a conserved viral byproduct (dsRNA) rather than engaging viral machinery.^[20] This host-directed approach enhances broad applicability and reduces the likelihood of viral evasion.^[20]

Preclinical Testing

In Vitro Efficacy Results

In cell culture experiments conducted as part of the initial 2011 study at MIT, DRACO exhibited potent antiviral activity against 15 diverse viruses, including H1N1 influenza, dengue virus, and poliovirus, with half-maximal effective concentrations (EC₅₀) ranging from approximately 10 to 100 nM.^[2] These tests were performed in multiple mammalian cell lines, such as human lung fibroblasts (NHLF) and mouse L929 cells, where DRACO selectively induced apoptosis in virus-infected cells while sparing uninfected ones.^[2] The compound's toxicity profile was favorable, with no observable cytotoxicity in uninfected cells at concentrations up to 1 μM.^[2] This selectivity stems from DRACO's activation by double-stranded RNA, a hallmark of viral replication, as briefly referenced in its targeting mechanism.^[2] Across enveloped viruses like H1N1 influenza and non-enveloped viruses such as adenovirus, as well as both RNA viruses (e.g., poliovirus) and DNA viruses (e.g., adenovirus), DRACO reduced viral titers by 90-99% in treated cultures, often rendering them undetectable within days post-infection.^[2] Independent validations have corroborated these findings. In a 2015 study using Marc-145 cells and porcine alveolar macrophages, DRACO achieved near-complete (up to 100%) inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication at concentrations of 40-100 mg/L, with no associated toxicity.^[13] Similarly, a 2020 investigation in Madin-Darby canine kidney (MDCK) cells confirmed DRACO's efficacy against H1N1 influenza, demonstrating significant, dose-dependent suppression of viral replication without harming uninfected cells.^[17] As of 2024, Kimer Med reported additional in vitro success with improved DRACO variants against 10 viruses, including Dengue and Zika, achieving 100% positive results in tests.^[4]

In Vivo Animal Studies

In vivo studies of DRACO primarily utilized adult BALB/c mice as a model for systemic antiviral efficacy, focusing on influenza A H1N1 virus challenge to assess survival, viral load reduction, and pharmacokinetics. In these proof-of-concept experiments, mice were administered DRACO variants such as PTD-PKR-Apaf, TAT-PKR-Apaf, and RNaseL-Apaf via intraperitoneal injection at doses of 0.8–2.5 mg per day (approximately 40–125 mg/kg based on a standard 20 g mouse weight) from day -1 to day 3 relative to intranasal viral challenge with 0.3–1.3 LD₅₀ of H1N1 A/PR/8/34.^[2] Treated groups demonstrated complete prevention of morbidity, resulting in up to 100% survival (for RNaseL variants), in contrast to untreated controls that exhibited low survival rates (less than 10%).^[21]^[2] These treatments also significantly reduced lung viral titers by more than one order of magnitude on day 2 post-infection compared to controls, highlighting DRACO's ability to limit viral replication in a whole-organism setting.^[2] Intranasal administration of DRACO on day 0 similarly reduced morbidity against 1 LD₅₀ H1N1 challenge, with approximately 0.5 mg single doses achieving comparable protective effects.^[2] No overt toxicity was observed in treated mice, as evidenced by normal organ histology in liver, kidney, and lungs post-administration.^[2] Pharmacokinetic analysis revealed favorable biodistribution following intraperitoneal delivery, with DRACO penetrating key organs including the lungs, liver, and kidneys, and persisting for at least 48 hours.^[2] Intranasal dosing showed lung penetration with persistence exceeding 24 hours.^[2] This distribution profile, coupled with an estimated half-life of approximately 24 hours, supports once- or twice-daily dosing regimens for sustained antiviral activity.^[2] While these results underscore DRACO's translational potential from in vitro efficacy, variability in immune responses across animal cohorts and the need for formulation optimizations to enhance brain delivery for neurotropic viruses remain areas for further investigation.^[2]

Derivatives and Current Research

Kimer Med's VTose Platform

Kimer Med, a New Zealand-based biotechnology company, was founded in August 2020 to advance broad-spectrum antiviral therapies derived from earlier academic research on DRACO. In 2021, the company licensed the final DRACO-related patent from MIT, enabling the development of VTose as a proprietary, modular platform for designing and optimizing antiviral candidates. This platform builds on the original DRACO concept by utilizing recombinant fusion proteins that target double-stranded RNA (dsRNA) produced during viral replication, triggering selective apoptosis in infected cells.^[22]^[23]^[24] Key improvements in the VTose platform include enhanced dsRNA binding for greater sensitivity to viral replication signals and a modular architecture with swappable protein domains for customized targeting to specific viruses, cell types, or tissues. Delivery is achieved through these engineered biologics, which improve specificity and pharmacokinetics compared to earlier prototypes, while preclinical data demonstrate reduced off-target effects and low toxicity across mammalian cell lines. These refinements address limitations in the original DRACO design, such as stability and delivery challenges, positioning VTose for broader therapeutic application.^[24]^[4] By 2024, VTose compounds had demonstrated in vitro efficacy against 21 viruses spanning nine families, including all four dengue serotypes, Zika, rhinovirus, and alphaviruses, with consistent low cytotoxicity. In June 2023, Kimer Med reported 100% success in cytopathic effect reduction assays against dengue serotypes 1 and 2, as well as Zika virus, marking significant milestones in validation against priority pathogens. These results expanded from initial tests against seven viruses to a more comprehensive panel, confirming the platform's potential for rapid adaptation.^[24]^[22]^[25]^[4]^[5] To support further preclinical advancement, Kimer Med secured NZD$14 million in a Series A funding round that closed in October 2024, bringing total investment to over NZD$18 million since inception. This capital is earmarked for optimizing lead candidates, expanding in vivo studies, and preparing for Phase 1 clinical trials.^[22]

Updates as of 2025

In March 2024, Kimer Med announced a partnership with Battelle Memorial Institute, securing a contract valued at up to USD$750,000 to discover and develop new antiviral drug candidates specifically targeting alphaviruses.^[26] This collaboration leverages Kimer Med's broad-spectrum antiviral platform to address high-priority pathogens, marking a significant step in advancing DRACO-derived compounds toward practical applications. As of July 2025, ongoing in vivo studies have confirmed the low toxicity of Kimer Med's antiviral compounds, with early data demonstrating safety and efficacy in animal models; additional mouse studies are currently underway to further validate these results.^[27] In vitro efficacy testing has shown activity against 21 human viruses spanning 9 virus families, underscoring the platform's potential for broad-spectrum use.^[24] As of November 2025, Kimer Med remains focused on continuously improving the VTose formulation, expanding delivery options, and enhancing overall effectiveness.^[28] Kimer Med's VTose platform continues to drive these developments, building directly on the original DRACO technology. The company is actively preparing for pre-IND interactions with regulatory authorities, with Phase 1 human trials targeted for initiation in 2026-2027 contingent on additional funding and successful completion of preclinical milestones.^[29] To date, no human clinical data exists for DRACO derivatives, presenting challenges such as navigating regulatory pathways designed primarily for pathogen-specific drugs rather than broad-spectrum agents.^[30] Currently, no active development of DRACO occurs at the original laboratories, with all progress centered at Kimer Med.^[29]

Applications and Challenges

Broad-Spectrum Antiviral Potential

DRACO's broad-spectrum antiviral mechanism, which targets double-stranded RNA produced by diverse viruses during replication, positions it as a promising candidate for prophylactic applications in high-risk populations. By inducing apoptosis selectively in infected cells, DRACO offers a potential alternative to traditional vaccines, providing protection against unknown or emerging viral threats without the need for virus-specific antigens. This is particularly relevant for groups such as military personnel deployed to regions with high viral diversity or international travelers exposed to novel pathogens, where preemptive administration could confer extended protection lasting up to several weeks based on persistence in cellular models.^[2]^[1] In therapeutic contexts, DRACO demonstrates efficacy against acute viral infections, including influenza and dengue, by reducing viral titers and rescuing infected hosts when administered post-exposure. Its mechanism enables treatment windows of up to three days after infection onset, making it suitable for rapid intervention in symptomatic cases. Furthermore, due to its non-specific targeting of viral dsRNA, DRACO holds potential for combination therapies with existing antivirals for chronic infections like HIV and hepatitis, where it could complement protease inhibitors or other agents to enhance clearance of persistent viral reservoirs.^[2]^[31] For pandemic response, DRACO's design supports rapid deployment against emerging threats, as evidenced by its modeled efficacy against coronaviruses similar to the 2003 SARS outbreak and its demonstrated activity against H1N1 influenza in animal models. This broad applicability could facilitate stockpiling and emergency use for novel viruses like SARS-CoV-2, bypassing the delays associated with developing targeted vaccines or antivirals. Delivery formats tailored to infection routes enhance its versatility: intranasal administration or inhalers for respiratory viruses such as influenza, and systemic injectables for widespread threats like dengue or hemorrhagic fevers.^[1]^[2]

Limitations and Future Directions

One major limitation of DRACO is the challenge of achieving efficient delivery into human cells in vivo, as the therapy relies on transduction peptides or transfection agents that perform well in preclinical models but may not scale effectively to clinical settings without further optimization.^[32] Additionally, certain viruses can evade DRACO's mechanism by producing minimal double-stranded RNA (dsRNA) or sequestering it to inhibit detection, as seen with poxvirus proteins like E3L that suppress the innate immune response.^[10] High development costs further hinder progress, given the need for extensive optimization of dsRNA binding, apoptosis induction, and pharmacokinetics across multiple viral targets, which demands significant upfront investment in a field with fragmented funding.^[33] Safety concerns include the potential for over-activation of host apoptosis pathways, particularly in individuals with autoimmune conditions where endogenous dsRNA or immune dysregulation could trigger unintended cell death, although preclinical studies showed no toxicity in uninfected cells or mice.^[10] Long-term effects remain unknown due to the absence of human data, and as a host-directed therapy, DRACO risks on-target toxicity similar to other broad-spectrum approaches that modulate innate immunity.^[33] Regulatory issues compound these barriers; broad-spectrum agents like DRACO face FDA classification challenges, requiring virus-specific efficacy demonstrations despite their pan-viral design, along with difficulties in standardizing clinical endpoints beyond traditional measures like mortality.^[33] Future directions focus on advancing DRACO derivatives through Kimer Med's VTose platform, which is preparing to initiate Phase 1 human trials, with ongoing preclinical optimization including additional in vivo studies as of 2025, following funding milestones achieved in 2024.^[34] Key recent developments include the June 2023 announcement of 100% efficacy against Dengue (DENV-2) and Zika (ZIKV) in independent lab tests, demonstration of efficacy against up to 11 viruses by 2024, and a March 2024 contract with Battelle Memorial Institute valued at USD 750,000 to develop candidates for alphaviruses.^[35]^[5] Efforts include developing improved in vivo models for non-respiratory viruses to address research gaps in efficacy against diverse pathogens, as well as exploring combination therapies to mitigate evasion mechanisms.^[10] Kimer Med's ongoing partnerships, such as with Battelle Memorial Institute, support targeted development for priority viruses like alphaviruses.^[5]

References

[1]
DRACO: Demonstration Rocket for Agile Cislunar Operations - DARPA
The Demonstration Rocket for Agile Cislunar Operations (DRACO) program is an effort to advance nuclear propulsion technology for critical space missions.
[2]
NASA, DARPA Will Test Nuclear Engine for Future Mars Missions
Jan 24, 2023 · NASA and DARPA will partner on the Demonstration Rocket for Agile Cislunar Operations, or DRACO, program. The non-reimbursable agreement ...
[3]
Nuclear Reactor Test Requirements Put DRACO Launch Plans On ...
Jan 17, 2025 · The 2027 launch date for the Demonstration Rocket for Agile Cislunar Operations (DRACO) is on indefinite hold.
[4]
DARPA says decreasing launch costs, new analysis led it to cancel ...
Jul 2, 2025 · DARPA's decision to cancel DRACO comes as NASA is proposing to abandon its own nuclear propulsion technologies. The fiscal year 2026 budget ...
[5]
DARPA's DRACO nuclear propulsion project ROARs no more
Jun 27, 2025 · DRACO's demise was first reported by Ars Technica earlier this month, based on NASA's fiscal 2026 budget request that zeroed the program.
[6]
Broad-Spectrum Antiviral Therapeutics | PLOS One
We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces ...
[7]
New drug could cure nearly any viral infection | MIT News
Aug 10, 2011 · Todd Rider invented the PANACEA and DRACO antiviral therapeutics, and previously invented the CANARY (Cellular Analysis and Notification of ...
[8]
Broad-spectrum antiviral therapeutics - PubMed - NIH
We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces ...
[9]
Antivirals: Past, Present and Future - PMC - NIH
The uses of antiviral agents are increasing in the new era along with the development of vaccines for the effective control of viral diseases.Prologue · Fig. 22.1 · Repurposing Of Drugs
[10]
Broad-Spectrum Antiviral Therapeutics - PMC - NIH
We have created DRACOs and shown that they are nontoxic in 11 mammalian cell types and effective against 15 different viruses, including dengue flavivirus, ...Missing: impact | Show results with:impact
[11]
The costs and benefits of primary prevention of zoonotic pandemics
Feb 4, 2022 · Thus, the baseline annual expected loss in GNI from viral zoonotic disease outbreaks is $212 billion. If prevention actions cut those economic ...Zoonotic Pandemics Are... · Costs Of Pandemics · Primary Prevention<|separator|>
[12]
Todd Rider Joins Draper to Continue Antiviral Therapeutics ...
Jan 8, 2014 · Cambridge, MA (PRWEB) January 08, 2014 -- Todd Rider has joined Draper Laboratory to continue his work on treatments that are effective ...Missing: transfer | Show results with:transfer
[13]
DRACO inhibits porcine reproductive and respiratory syndrome ...
DRACO exhibits robust antiviral activity against PRRSV by suppressing virus RNA and protein synthesis, and holds promise as a novel anti-PRRSV therapeutic drug.Missing: validation Draper
[14]
Todd Rider Is Crowdfunding His DRACO Antiviral Research
Dec 15, 2015 · Four years ago, Todd Rider was on top of the world. The MIT-trained bioengineer had developed a radical idea for killing viruses.
[15]
About | RIDER Institute | Founded by Dr. Todd H. Rider
... Laboratory 1997–2013, and served as senior Laboratory Technical Staff at Draper Laboratory 2013–2015. In 2015 he founded the RIDER (Revolutionary Innovation ...Missing: departure | Show results with:departure
[16]
The RIDER Institute is crowdfunding $2,000,000 for DRACO antiviral ...
May 11, 2016 · PRNewswire/ -- The RIDER Institute has launched an Indiegogo crowdfunding campaign to fund DRACO broad-spectrum antiviral therapeutics, ...Missing: 2015 | Show results with:2015
[17]
DRACO May Be A Cure For All Viral Infections by Todd Rider
We are now raising funds to test and optimize DRACOs against the herpesvirus family, which contains many major clinical viruses such as Herpes Simplex Virus 1 ( ...
[18]
Double-Stranded RNA Activated Caspase Oligomerizer (DRACO)
Double-Stranded RNA Activated Caspase Oligomerizer (DRACO): Design, Subcloning, and Antiviral Investigation. Document Type : Original Article. Authors. Mojtaba ...
[19]
US7566694B2 - Anti-pathogen treatments - Google Patents
Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating ...Missing: licensing 2015
[20]
https://doi.org/10.1371/journal.pone.0022572
[21]
DRACOs: New Antivirals Against Pretty Much Everything? - Science
Aug 22, 2011 · (Of course, their broad antiviral effects, versus the sometimes way-too-specific nature of a vaccine, is a strong point in their favor).Missing: advantages | Show results with:advantages
[22]
Broad-Spectrum Antiviral Drug Development Progress - Kimer Med
- Merck Emerging Biotech Grants 'Special Mention' winners. Oct - Closed NZ$14M Series A capital raise. Aug - Honoured in Fierce Biotech's 2024 'Fierce 15' - the ...
[23]
Viruses cause 200+ diseases. This one drug may be able to treat ...
and new ones.<|control11|><|separator|>
[24]
Broad-spectrum Antiviral Platform and the science behind it
Kimer Med's proprietary platform enables the rapid design and optimisation of novel, broad-spectrum antiviral drug candidates.Missing: VTose DRACO
[25]
An Update on Kimer Med, Improving on the DRACO Antiviral ...
Feb 23, 2024 · What happened to DRACO? When Dr Todd Rider announced his breakthrough DRACO discovery in 2011, the world sat up and took notice. Headlines ...
[26]
Nelson biotech start-up Kimer Med confirms its antiviral compound's ...
Jun 7, 2023 · Kimer Med's antiviral compound, VTose, demonstrated 100% effectiveness against both Dengue and Zika virus in viral cytopathic effect (CPE) reduction assays, ...
[27]
Kimer Med inks contract with Battelle Memorial Institute to discover ...
Mar 11, 2024 · The company optimising new, broad-spectrum antiviral drugs. Its antivirals are a derivative of DRACO, which was tested and found effective in ...Missing: VTose | Show results with:VTose<|control11|><|separator|>
[28]
Invest - Kimer Med Limited Ordinary Shares - Catalist
The VTose® Antiviral Platform. Kimer Med has built and refined a proprietary Platform for broad-spectrum antiviral development. ... It was nicknamed DRACO ...
[29]
Kimer Med | Discover Antiviral Solutions — Act Now
Advancing broad-spectrum antivirals to combat global viral threats and pandemics. Learn about our pipeline, progress, and partnership opportunities.The Facts About Kimer Med · Company · Progress · Viruses
[30]
Broad-spectrum antiviral agents - Frontiers
DRACO appears to be an optimal broad-spectrum antiviral agent for further development. Autophagy is a basic cellular mechanism for degradation of unnecessary ...Missing: advantages | Show results with:advantages
[31]
DRACO: A Broad-Spectrum Therapy Against Multiple Viruses - POZ
Aug 12, 2011 · ... prove to be effective against virtually all viruses, including HIV and hepatitis, according to a report published online by PLoS One.
[32]
SARS-CoV-2: An Update on Potential Antivirals in Light of ... - NIH
DRACO has shown antiviral activity against many RNA viruses in vitro and in vivo. Similar to siRNAs, efficient delivery of DRACO into cells remains a challenge.Missing: impact | Show results with:impact
[33]
Accelerating antiviral drug discovery: lessons from COVID-19 - Nature
May 12, 2023 · We outline key lessons from rapid antiviral drug discovery efforts, or 'sprints', and articulate remaining open questions.Missing: DRACO | Show results with:DRACO<|separator|>
[34]
Introducing Fierce Biotech's 2024 Fierce 15
Aug 5, 2024 · To get the drug into early-stage clinical trials, Kimer Med is in the process of raising a 14 million New Zealand dollar ($6.1 million) ...