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David Agus


David B. Agus is an American medical oncologist, professor of medicine and at the Keck School of Medicine and Viterbi School of Engineering of the (), and author focused on and cancer therapeutics.
As founding director and CEO of USC's Lawrence J. Ellison Institute for Transformative Medicine, Agus oversees research integrating advanced technologies for precision cancer treatments and health decision-making tools.
His contributions include co-founding biotech firms such as Applied Proteomics and Navigenics to advance proteomic and genomic applications in healthcare, alongside over 100 peer-reviewed publications on tumor genomics and personalized therapies.
Agus has earned awards including the 2009 Geoffrey Beene Foundation Rock Stars of Science Award, the Physician Research Award, and the 2017 for his biomedical innovations.
He authored three New York Times bestselling books—The End of Illness (2012), A Short Guide to a Long Life (2014), and The Lucky Years (2016)—advocating data-driven health maintenance.
Agus served on the medical team treating Apple co-founder for in his final years.
In 2023, Agus encountered substantial controversy when his co-authored book The Book of Animal Secrets was suspended and recalled by following revelations of extensive , including unattributed passages from and other sources, with collaborator Kristin Loberg admitting to copying at least 95 sections; Agus subsequently rewrote and re-released a version.

Early Life and Education

Upbringing and Family Influences

David B. Agus was born on January 29, 1965, in , . He grew up in within a Jewish family emphasizing intellectual and professional pursuits. His father, Zalman S. Agus, M.D., was a nephrologist and professor emeritus of medicine and physiology at the , specializing in . His mother worked as a nursery school teacher. Agus's paternal grandfather, Rabbi Jacob B. Agus, was a prominent theologian, scholar, and rabbi who authored works on and , such as The Evolution of Jewish Thought, influencing the family's commitment to rigorous inquiry and ethical reasoning. Despite this heritage, Agus described his immediate family as conservative and risk-averse, with his parents adhering strictly to established norms, which contrasted with his own emerging inclination toward innovation and experimentation. As a child, he was identified as gifted through aptitude tests in the post-Sputnik era, gaining early access to scientific laboratories via government programs, where he conducted experiments—such as injecting rats—rather than engaging in typical social activities like summer camps. These experiences, including high school lab work, fostered his passion for biomedical research and a departure from familial caution toward bold scientific risk-taking.

Academic Training and Early Research

Agus earned a degree in from in 1987, graduating cum laude with honors. He then attended the University of Pennsylvania School of Medicine, receiving his Doctor of Medicine degree in 1991. Following medical school, Agus completed an internship and residency in at from approximately 1991 to 1994. He subsequently pursued an oncology fellowship at Memorial Sloan-Kettering Cancer Center in from 1994 to 1996, extending his training there as a in medical through 1997. During and immediately after his fellowship at Memorial Sloan-Kettering, Agus began his early research focusing on translational studies in , including investigations into regulators and response to . His work emphasized mechanisms of treatment resistance in advanced and the role of signaling pathways such as HER-2/neu in tumor progression. By 1999, he held a position as Assistant Member in the Department of Medical Oncology at the center, contributing to preclinical models for targeted cancer therapies.

Professional Career

Academic and Research Positions

Agus completed a fellowship in medical at from 1994 to 1996. He subsequently held the position of Assistant Member in the Department of Medical at the same institution from 1999 to 2000, where he contributed to early research in cancer therapeutics. In 2009, Agus joined the as professor of medicine at the Keck School of Medicine and professor of biomedical engineering at the Viterbi School of Engineering. In these roles, he has focused on integrating engineering principles with clinical to advance personalized treatment strategies. Agus founded and directs the Center for Applied Molecular , leading efforts to translate molecular research into clinical applications for complex diseases like cancer. He also serves as the founding director and CEO of the J. Ellison Institute for Transformative at , overseeing multidisciplinary teams developing data-driven technologies to guide precision diagnostics and therapies. Additionally, he directs the USC Westside Center, emphasizing innovative approaches to prostate .

Clinical Practice and High-Profile Cases

David B. Agus serves as a medical oncologist at the University of Southern California's Keck School of Medicine, where he specializes in treating patients with advanced cancer. His clinical responsibilities encompass the development and oversight of clinical trials for novel drugs and therapies, funded in part by the National Cancer Institute. Agus leads a multidisciplinary team focused on integrating biomedical engineering and molecular medicine to enable technology-driven, personalized treatment decisions, particularly in areas such as prostate cancer and drug resistance mechanisms. As director of the USC Center for Applied Molecular Medicine and the Lawrence J. Ellison Institute for Transformative Cancer Research, he emphasizes empirical data and real-time monitoring to tailor interventions, drawing from his research on cancer biomarkers. Agus has been involved in the care of several high-profile patients with advanced malignancies. He was part of the medical team treating Apple co-founder during the final years of his battle with , where Agus later attributed Jobs's prolonged survival in part to eventual adherence to conventional therapies after initial pursuit of alternatives, while critiquing deviations from evidence-based protocols influenced by the patient's celebrity status—a phenomenon known as VIP syndrome. He also treated cyclist , media mogul , Senator , and former Congressman , among other prominent individuals facing terminal illnesses. These cases underscore Agus's practice of applying approaches to complex, late-stage scenarios, often in collaboration with elite institutions.

Biotech Entrepreneurship

Agus co-founded Navigenics in 2006, a company specializing in for . The firm offered genomic risk assessments for common diseases such as cancer, heart disease, and , aiming to enable preventive health strategies based on individual genetic profiles. Navigenics operated until its acquisition by in 2012, which integrated the technology into broader genomic services. In parallel with his academic work, Agus co-founded Applied Proteomics around 2011 in collaboration with computer scientist , focusing on for cancer diagnostics and monitoring. The company developed high-throughput platforms to quantify proteins in blood samples, targeting early detection and treatment response prediction for cancers like prostate and varieties, where traditional biomarkers fell short. This approach emphasized systems-level analysis of protein networks over single-molecule focus, drawing on Agus's research in tumor biology to bridge lab discoveries with clinical applications. Applied Proteomics raised significant venture funding, including from investors like , to scale its mass spectrometry-based assays. Agus also contributed to Oncology.com, an early online launched in the late to connect cancer patients with specialists and resources, reflecting his interest in digital tools for care coordination. While less emphasized in his portfolio than and ventures, it underscored his push for technology-enabled in cancer management. These entrepreneurial efforts aligned with Agus's advocacy for data-driven, individualized therapies, though critics noted challenges in translating genomic insights into actionable outcomes amid regulatory and interpretive hurdles in .

Authorship and Publications

Major Books and Themes

David Agus has authored several New York Times bestselling books that advocate for a paradigm shift in healthcare toward prevention, personalization, and data integration. His works emphasize viewing the body as a dynamic system rather than isolated organs, challenging reactive treatment models in favor of proactive strategies informed by technology and empirical observation. In The End of Illness (2012), Agus argues for redefining by treating the body as a complex, interconnected system, prioritizing prevention over cure through continuous monitoring and technological interventions like sensors and analytics. The book critiques siloed medical specialties and promotes a holistic approach, drawing on examples from to illustrate how environmental and factors influence trajectories, urging readers to decode subtle bodily signals—such as changes in or —for early . A Short Guide to a Long Life (2014) distills preventive principles into actionable rules across three sections: "What to Do," "What to Avoid," and "Doctor's Orders," focusing on evidence-based habits like consistent , balanced , and avoiding extremes in or supplementation. Agus stresses and consistency over fads, advocating for aspirin use in certain contexts and regular check-ups to mitigate chronic disease risks, grounded in controlled studies rather than anecdotal trends. The Lucky Years: How to Thrive in the Brave New World of Health (2016) extends these ideas by framing the 21st century as an era of unprecedented medical progress, enabled by , wearables, and , which allow individuals to personalize and extend healthy lifespans. Key themes include harnessing for predictive —such as tracking , activity, and biomarkers—and emphasizing personal responsibility in leveraging these tools, while cautioning against over-reliance on unproven therapies. The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life (2023) draws biological insights from animal behaviors to inform human health, exploring how like demonstrate altruism's benefits, model joyful living, and prairie voles reveal bonding's role in resilience against and . Agus applies these observations to human contexts, suggesting evolutionary adaptations—such as collaborative networks and sensory attunement—can combat modern ailments like cancer and through lifestyle emulation rather than solely pharmaceutical means.

Plagiarism Allegations and Aftermath

In March 2023, a investigation identified at least 95 instances of unattributed copying in the manuscript of David Agus's forthcoming book The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life, including passages lifted or nearly so from sources such as entries, academic journals, and news articles without quotation or citation. The plagiarism detection software , used by the newspaper, revealed multi-paragraph sections replicated from external works, prompting to suspend distribution and halt publication just before the planned March 7 release date. Agus issued a statement acknowledging the seriousness of the claims, apologizing to affected scientists and writers, and announcing an immediate review of his prior works while directing the publisher to delay the book until corrections could be made. Subsequent reporting expanded the scope, uncovering over 120 plagiarized passages across Agus's three earlier books—The End of Illness (2012), A Short Guide to a Long Life (2014), and The Book of Microdosing (2018)—again detected via iThenticate and involving uncredited material from scientific papers, books, and online sources. All four books had been co-authored with Kristin Loberg, a Los Angeles-based writer who accepted primary responsibility for the lapses, stating in a March 2023 email that she had failed to properly attribute sources during drafting and assuring Agus that manuscripts had been cleared by plagiarism software, which proved inaccurate. Loberg, who had collaborated on multiple celebrity health titles, faced separate scrutiny for similar unattributed borrowings in works with other authors, including CNN's Sanjay Gupta, highlighting patterns in her contributions rather than isolated errors. Agus responded by severing ties with Loberg and personally rewriting The Book of Animal Secrets to eliminate the issues, as he explained in a 2023 CBS Mornings interview, emphasizing his reliance on the co-author for research integration while assuming final accountability as the named author. The revised edition was published by on December 5, 2023, without Loberg's involvement. Earlier books remained in print without formal recalls, though publishers continued assessing affected titles into late 2023, with no public announcements of withdrawals or revisions for Agus's prior works. The University of Southern California's Keck School of Medicine, where Agus holds a professorship, stated it would review the allegations but disclosed no outcomes or disciplinary actions by mid-2025. Agus retained his roles in , media commentary, and practice, with no evident interruption to his public engagements or institutional positions stemming from the incident.

Public Engagement and Media Presence

Television and News Commentary

David B. Agus joined as a contributor in May 2013, providing commentary on a wide array of medical and health-related topics across the network's broadcasts. In this role, he has frequently appeared on programs such as to discuss issues, including guidance on post-vaccination behaviors during the in March 2021, where he advised on resuming activities while emphasizing continued precautions. His contributions often focus on translating complex biomedical research into actionable insights for general audiences, drawing from his expertise in and . In November 2022, Agus launched The Checkup with Dr. David Agus, a Paramount+ original mini-series in which he conducts intimate interviews with celebrities about their personal health challenges and medical histories. Guests have included actors such as , , , , and , who share experiences with conditions like joint pain, fertility issues, and chronic illnesses, allowing Agus to offer data-informed perspectives on prevention and treatment. The series, produced in collaboration with , aims to demystify healthcare through real-world anecdotes, with episodes highlighting themes like the role of lifestyle factors in disease management. Beyond CBS, Agus has provided expert commentary on other networks, including . In March 2025, he discussed rising cancer rates among younger adults, attributing trends to environmental and lifestyle shifts based on epidemiological data. He also appeared on The David Rubenstein Show on in a February 2025 episode, addressing cancer , , and incidence patterns with an emphasis on empirical evidence from clinical studies. Additionally, Agus has featured on late-night programs like Starring in April 2024, where he elaborated on health benefits derived from pet ownership, linking animal-human interactions to outcomes supported by observational . During the early response in 2020, Agus combined on-air analysis with behind-the-scenes advisory work for the , appearing on television to explain technical aspects of pandemic management while critiquing overly simplistic messaging. His media presence underscores a consistent for evidence-based, individualized strategies over generalized recommendations.

Lectures and Public Advocacy

David Agus has delivered lectures and engaged in public advocacy emphasizing innovative approaches to , , and data-driven health strategies. In a 2010 TED talk, he advocated for a cross-disciplinary shift in , criticizing the narrow focus on individual cells and proposing to address cancer as a dynamic process influenced by , , and . He has spoken multiple times at TEDMED conferences, including in 2009 on redefining cancer as a lifelong balance rather than a singular disease, and in 2011 expanding on therapeutic frameworks. Agus presented at TEDxUSC in 2010, discussing technology's role in advancing through and for cancer therapies. In collaboration with Jay Walker at TEDMED 2013, he outlined a integrating and to improve outcomes. His extends to promoting aspirin for and routine health monitoring, as highlighted in a 2012 92Y talk with . At the , Agus has participated in panels and discussions on issues, including a 2016 session with Vice President on cancer initiatives and a 2017 conversation on technology's future in healthcare. In a 2012 WEF contribution, he urged embracing to combat non-communicable diseases, arguing that personalized approaches could reduce NCD burdens surpassing infectious diseases. During 2019, he addressed health challenges linking global and local issues. Agus continues public through recent platforms, such as a September 2025 podcast episode on leveraging data narratives for policy and involvement in advocacy. His lectures often tie to book themes, like practical health rules from A Short Guide to a Long Life discussed in 2014 events. These efforts underscore his push for evidence-based, technology-integrated preventive care over reactive treatments.

Medical Philosophy and Contributions

Advocacy for Personalized Medicine

David Agus has positioned himself as a leading proponent of , which tailors healthcare interventions based on an individual's genetic makeup, lifestyle data, and molecular profiles rather than standardized protocols. As chair of the World Economic Forum's Global Agenda Council on Genetics, he has influenced international discussions on integrating into clinical practice to predict risks and optimize treatments. In his 2012 book The End of Illness, Agus critiques the limitations of one-size-fits-all medicine, proposing instead a approach that views the body as an interconnected network responsive to personalized data inputs like and . To demonstrate practical application, he released his own full genetic profile online, arguing that such transparency empowers patients and physicians to preempt illnesses through customized prevention strategies. This advocacy extends to his co-founding of Navigenics in 2007, a firm aimed at assessing hereditary risks for conditions like cancer and to guide individualized health plans. Agus's 2016 book The Lucky Years builds on this foundation, framing the current era as one where technological advances enable proactive health management, including real-time data monitoring to adjust therapies dynamically and extend . He emphasizes crunching vast datasets from wearables and biomarkers to "edit" lifestyle factors and predict outcomes, warning that failure to adopt such methods perpetuates inefficient, reactive care. Addressing systemic barriers, Agus has called for realigning healthcare incentives—such as reimbursing over episodic treatments—to realize personalized medicine's potential, noting that current models discourage upfront investments in patient-specific diagnostics. In recent discussions, he highlights artificial intelligence's role in enhancing this paradigm by accelerating drug matching and in molecular data, potentially transforming and chronic disease management.

Data-Driven Health Monitoring and Criticisms

Agus promotes the integration of continuous from wearable devices and digital tools to facilitate proactive monitoring and personalized interventions, arguing that such data empowers individuals to prevent illness rather than merely treat it. In his 2016 book The Lucky Years, he urges patients to use wearables such as smartwatches and bracelets to track , , , and other vitals, delivering this information to physicians via biochips or pre-appointment uploads to guide diagnostics and reduce unnecessary visits. He envisions telemedicine and home-based scans, including EKGs and retinal imaging, feeding into aggregated, anonymized databases for broader through techniques like and VirScan for viral exposure history. To operationalize this, Agus outlines practical steps like a two-week baseline challenge where individuals log sleep, diet, exercise, and using apps for ECG and breathing monitoring, combining these with routine blood tests to customize regimens such as Mediterranean diets supplemented by low-dose aspirin or statins based on personal risk profiles. More recently, he has endorsed self-tracking devices like Oura rings for real-time feedback loops that prompt behavioral adjustments, with enhancing analysis to uncover subclinical trends, as in linking vaccines to reduced Alzheimer's risk via large-scale . Critics contend that Agus's insistence on amassing until "error goes away" exhibits , potentially prioritizing technological optimism over rigorous validation, as his presentations sometimes amplify preliminary findings. In , five physicians rebutted his claims on heart attack prevention via daily aspirin, accusing him of overstating benefits and risks in public forums to advance his brand, despite clinical trials showing modest absolute reductions in events for low-risk groups. Additional concerns involve physicians' for processing patient-generated floods, which could strain clinical judgment, alongside vulnerabilities in data sharing, though mitigated by laws like the 2008 prohibiting employer use of genetic for discrimination. Agus maintains that empirical accumulation, informed by engineering principles, outperforms reactive medicine, countering skeptics by citing successes in modeling where integrated datasets improve prognostic accuracy.

Challenges to Conventional Medical Practices

Agus has argued that conventional medical practices often adopt a reactive stance, addressing illnesses only after symptoms manifest, rather than preventing disruptions in the body's integrated systems. In his book The End of Illness, he posits that health should be viewed as maintaining balance in the body's molecular networks, challenging the disease-centric model that silos specialties and overlooks interconnected physiological processes. This approach, he contends, stems from outdated paradigms that treat symptoms in isolation, ignoring how perturbations like or genetic variations affect the whole organism. In specifically, Agus critiques the "" as a strategy of attrition, with treatments like focusing narrowly on tumor cells without addressing the systemic environment that enables disease progression. During a TEDMED , he emphasized that cancer comprises hundreds of distinct conditions, not a singular amenable to uniform eradication tactics akin to bacterial infections, and advocated managing it as a ailment through protein signaling analysis and atypical interventions. He has further highlighted how this narrow fixation on cancer specifics hampers broader insights, potentially causing unintended harm by diverting resources from interdisciplinary modeling of host-tumor dynamics. Agus also warns against deviations from evidence-based protocols, such as unproven supplements or extreme diets, which can interfere with effective therapies; he cited treating Apple co-founder in 2009, who delayed conventional surgery for after pursuing a fruitarian regimen, later expressing regret over the lost time. Over 60 clinical studies, he notes, demonstrate no benefits from multivitamins—only risks like increased cancer incidence—underscoring how such practices undermine rigorous . Instead, he promotes augmenting conventional care with from wearables and genomic to personalize prevention, arguing that slow institutional consensus and exacerbate reliance on ineffective alternatives.

Leadership Roles and Recent Developments

Founding the Ellison Institute

In May 2016, co-founder donated $200 million to the () to create the Lawrence J. Ellison Institute for Transformative Medicine, an interdisciplinary research center aimed at advancing personalized cancer treatments through integration of molecular medicine, engineering, data analytics, and holistic patient care. David Agus, then director of USC's Center of Applied Molecular Medicine, was appointed founding director and CEO, leveraging his prior work in pathways and therapies to shape the institute's focus on "changing the soil" of disease environments rather than solely targeting individual tumors. The institute's establishment stemmed from discussions between Agus and Ellison, emphasizing from clinical, genomic, and sources to enable predictive modeling and transformative interventions. Initial included of multidisciplinary teams in , bioinformatics, and , with early projects exploring real-time health monitoring via wearable sensors and AI-driven analytics to shift from reactive to preventive . By 2021, the institute's physical facility opened in , expanding clinical operations including the USC Westside Cancer Center under Agus's leadership. Under Agus's direction, the Ellison Institute evolved into a broader platform, rebranding elements as the Ellison Medical Institute and contributing to the global Ellison Institute of Technology (EIT) network, which Agus co-leads as founding director and co-CEO alongside figures like and Sir John Bell. This expansion, building on the 2016 foundation, incorporates engineering and technology hubs in locations such as , prioritizing scalable solutions for complex diseases through empirical data and causal modeling.

Focus on AI, Longevity, and Emerging Technologies

Agus leads the Ellison Medical Institute, which maintains dedicated innovation labs for and molecular analytics to advance data-driven therapies and preventive medicine. In March 2025, the institute partnered with Salt to develop workflows for cancer , leveraging models for image analysis and molecular simulation to accelerate therapeutic development. Agus has highlighted AI's potential to transform research by analyzing vast biological datasets to identify aging mechanisms and interventions. In an August 2025 podcast interview, he predicted that AI-driven medical advancements could extend human lifespan by 10 to 15 years within the next 2 to 3 years through targeted therapies reversing cellular decline. He attributes this to AI's ability to process electronic medical records and uncover hidden patterns in that elude human analysis. On , Agus advocates integrating with for personalized health monitoring and predictive diagnostics, as evidenced by his oversight of interdisciplinary projects at combining , , and real-time sensor data. These efforts aim to shift from reactive treatment to proactive extension of healthy lifespan, though Agus cautions that augments rather than replaces clinical judgment.

Personal Life

Family and Relationships

David Agus married Amy Joyce Povich on June 6, 1994, at the home of her father, television host , in Povich is the daughter of and his first wife, Phyllis Minkoff. The couple announced their engagement in December 1993. Agus and Povich have two children and reside in . Public details about their children remain limited, reflecting the family's preference for privacy regarding personal matters. Agus was born to Dr. Zalman Agus and his wife in , where his family were longtime members of Congregation Beth El. No public records indicate additional marriages or significant relationships beyond his marriage to Povich.

Personal Health Practices and Philanthropy

Agus maintains a structured daily routine focused on preventive health measures, rising early—typically between 4 and 5 a.m.—to engage in an hour of exercise that alternates between yoga, Pilates, and tennis, despite expressing limited enthusiasm for yoga, noting its benefits for his body's needs. He incorporates a diet emphasizing fruits and vegetables and takes daily low-dose aspirin and statins as part of his personal regimen to mitigate chronic disease risks. In line with his advocacy for data-informed habits, Agus promotes and practices consistency in sleep, nutrition, and physical activity to minimize variability and stress, as detailed in his writings where he describes automating such routines to optimize longevity. Agus channels philanthropic efforts through leadership in non-profit medical research, serving as Founding CEO and President of the Ellison Institute Research Foundation, a 501(c)(3) organization dedicated to developing therapies and technologies for complex diseases via interdisciplinary data analytics and AI. The foundation, supported by major donations including $200 million from Larry Ellison in 2016, advances transformative medicine without direct personal financial contributions publicly detailed by Agus.

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