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Frontoparietal network

The frontoparietal network (FPN), also known as the frontoparietal control network, is a large-scale functional network primarily comprising regions in the (dlPFC) and the posterior parietal cortex (PPC), particularly around the (IPS). This network serves as a central hub for cognitive control, enabling the flexible coordination of goal-directed in response to varying task demands. Key functions of the FPN include supporting executive processes such as maintenance, attentional reorientation, and task switching, which allow for rapid adaptation to environmental changes. It dynamically interacts with other major brain networks, including the (for introspective cognition) and the (for external sensory processing), facilitating a balance between internal reflection and outward focus. Electrophysiological studies reveal that the FPN operates through theta/alpha oscillations (4–14 Hz), which underpin long-range communication and behavioral flexibility. The FPN exhibits notable heterogeneity, with at least two subsystems: one linked to the for regulating emotion and mentalizing, and another connected to the for visuospatial attention. This internal organization supports task-dependent recruitment and individual variability in network topography, which complicates group-level analyses but underscores the importance of precision mapping in . Disruptions in FPN connectivity and function are associated with psychiatric conditions such as , ADHD, anxiety, and , positioning it as a potential and therapeutic target for interventions.

Anatomy

Core Regions

The frontoparietal network (FPN) primarily comprises regions in the (DLPFC) and posterior parietal cortex (PPC), which serve as key nodes for cognitive processing. The DLPFC, located in the lateral aspect of the along the , corresponds to Brodmann areas (BA) 9 and 46. BA 9 occupies the and caudal , featuring a thin layer II, a visible but indistinct layer IV with fuzzy borders to layers III and V, medium to large neurons in deeper layer IIIc, large pyramidal cells in layer Va, a pale layer Vb, and an indistinct transition to layer VI and . In contrast, BA 46, situated more ventrally in the and extending to the middle frontal sulcus, exhibits a pronounced granular layer IV, homogeneous and compact cells in layer III, and a thick layer VI divided into two sublayers, supporting its role in . The PPC encompasses the (SPL) and (IPS), with extensions into the , including BA 7 and 39. The SPL, forming the dorsal portion of the , aligns with BA 7 and is characterized by a homogeneous cytoarchitecture with a broad layer III, bipartite layer V, and varying cell densities across subregions that facilitate visuospatial integration. The IPS serves as a central anatomical , a deep sulcus separating the SPL from the , and contains cytoarchitectonically distinct areas such as hIP3 (aligned with parts of BA 7) featuring high cell density in layers III and V, and extensions linking to BA 39 in the of the , which displays multimodal association features with wider layer IV and thinner layer V compared to adjacent regions. BA 39, located at the posterior apex of the , shows a distinct laminar organization with homogeneous layer III pyramids and enhanced connectivity profiles for higher-order processing. The FPN exhibits bilateral symmetry, with homologous regions present in both hemispheres, though the right hemisphere shows dominance in spatial attention aspects of these core areas. This organization underpins the network's involvement in adaptive cognitive control, as seen in intrinsic connectivity patterns.

Connectivity Patterns

The frontoparietal network exhibits robust structural connectivity primarily through major tracts that link the frontal and parietal cortices. The superior longitudinal fasciculus (SLF), a prominent bundle, provides direct bidirectional connections between prefrontal regions such as the and posterior parietal areas including the . This tract is subdivided into branches, with SLF II and III facilitating frontoparietal interactions essential for cognitive processing. Complementing the SLF, the arcuate fasciculus contributes to these linkages by curving around the insula to connect with , supporting integrated cortical communication. Diffusion tensor imaging studies have confirmed these tracts' roles in forming the anatomical backbone of the network, with fiber densities highest in dorsal pathways. Functionally, the frontoparietal network demonstrates synchronized activity patterns observable through (fMRI). In resting-state fMRI, regions within the network show positive correlations in low-frequency BOLD signal fluctuations, indicating intrinsic coupling that persists without external tasks. Task-based fMRI reveals enhanced connectivity during cognitive demands, such as or tasks, where frontal and parietal nodes dynamically synchronize to support . Notably, the network exhibits anti-correlations with the , particularly involving the posterior cingulate and medial prefrontal cortices, reflecting a push-pull dynamic that alternates between externally oriented and introspective processing states. These anticorrelations are a hallmark of large-scale organization, with seminal analyses showing their persistence even after global signal regression in resting-state data. Graph-theoretic analyses highlight the frontoparietal network's properties, underscoring its role in efficient information routing. The serves as a key , exhibiting high —the measure of connections to other —within the network's . This positions the as a high- , facilitating across frontal and parietal regions, with weighted metrics revealing stronger links during cognitive tasks compared to peripheral . Such properties align with the network's modular organization, where like the contribute to small-world characteristics, enabling rapid signal propagation with minimal wiring costs. The frontoparietal network integrates with subcortical structures via anatomical thalamocortical projections, forming closed loops that support network modulation. Projections from higher-order thalamic nuclei, such as the mediodorsal and pulvinar, extend reciprocally to frontal and parietal cortices, providing a conduit for sensory and attentional gating. These loops involve layered terminations in cortical layers, with thalamic inputs targeting middle layers of intraparietal and prefrontal areas to influence network excitability. Diffusion imaging and tract-tracing studies in confirm these projections' specificity, linking thalamic relays directly to frontoparietal hubs without extensive divergence.

Functions

Cognitive Control

Cognitive control refers to the top-down modulation of behavior to achieve goal-directed actions, involving the flexible adjustment of cognitive processes in response to environmental demands. In the context of the frontoparietal network, this encompasses the orchestration of such as and response inhibition, where the network acts as a flexible hub for integrating sensory information and guiding . Key processes supported by the frontoparietal network include conflict monitoring, inhibitory control, and flexible updating of task representations. Conflict monitoring involves detecting discrepancies between competing response options, with frontoparietal regions facilitating resolution through enhanced attentional biasing. Inhibitory control enables the suppression of prepotent responses to align actions with goals, particularly through interactions between the dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC). Flexible updating allows rapid reconfiguration of cognitive sets, as seen in paradigms requiring task rule adaptation, where the network supports the initiation of new behavioral strategies. Experimental evidence from studies highlights the network's activation during cognitive control tasks. In the Stroop task, which measures interference resolution by requiring color naming despite conflicting word meanings, fMRI reveals robust engagement of the frontoparietal network, including the and , during incongruent trials compared to neutral ones. Similarly, in paradigms assessing response inhibition, where participants withhold actions to infrequent "no-go" signals, the network shows heightened activity, with EEG demonstrating increased power (4-8 Hz) in frontoparietal sites correlating with successful inhibition. Neural mechanisms underlying these processes involve theta-band oscillations (4-8 Hz) that synchronize activity between the DLPFC and PPC, enabling long-range communication for control signaling. These oscillations intensify with rising control demands, such as during high-conflict decisions, and are thought to propagate top-down signals that modulate for goal attainment. Causal evidence from theta-frequency over prefrontal regions enhances inhibitory performance in tasks, underscoring the oscillatory basis of frontoparietal control.

Attention and Working Memory

The frontoparietal network plays a central role in attentional mechanisms, particularly in facilitating spatial and feature-based shifts that enable the selection of relevant stimuli from the environment. In tasks requiring rapid orienting, such as the Posner cueing paradigm, where peripheral or central cues direct to specific locations, the frontoparietal network interacts with the to support activation in regions including the (IPS) and (FEF), facilitating the disengagement and reorienting of to cued targets. This network modulates sensory processing by enhancing neural responses in contralateral to the attended location, thereby improving detection accuracy for validly cued stimuli while suppressing irrelevant distractors. Feature-based , which selects stimuli based on attributes like color or motion rather than location, similarly recruits frontoparietal areas to prioritize task-relevant features across the , as evidenced by increased BOLD signals in these regions during selective tasks. In (WM), the frontoparietal network contributes to the maintenance and manipulation of information over short periods, with distinct subcomponents handling storage versus active processing. The posterior parietal (PPC), particularly the , exhibits load-dependent activation during WM tasks, where neural activity scales with the number of items to be remembered, such as in paradigms requiring retention of 2-4 spatial locations. This load sensitivity reflects the PPC's role in buffering sensory representations for maintenance, while the (DLPFC) supports manipulation, such as rotating or comparing held items, through sustained firing patterns that integrate incoming updates. Direct frontoparietal pathways facilitate maintenance by relaying sensory inputs to prefrontal storage sites, whereas indirect pathways via subcortical structures enable flexible manipulation under varying cognitive demands. Electrophysiological studies reveal alpha-band desynchronization (8-12 Hz) as a signature of attentional orienting within the frontoparietal network, marking the suppression of irrelevant processing to prioritize task-relevant inputs. During spatial shifts in cueing tasks, alpha decreases over contralateral parietal and occipital regions, correlating with enhanced frontoparietal connectivity and faster reaction times to targets. This desynchronization propagates from frontal to parietal sites, coordinating the network's top-down control over sensory cortices. The network also integrates multisensory inputs to form cohesive WM buffers, binding visual and auditory stimuli for unified representation. In cross-modal WM tasks, frontoparietal regions show overlapping activation when maintaining pairings, such as associating tones with spatial locations, with connectivity gradients in the differentiating sensory-specific from supramodal processing. This binding supports robust short-term retention by leveraging parietal hubs to align temporal and spatial features across modalities, as seen in enhanced during dual-sense maintenance compared to unimodal conditions.

Development and Plasticity

Ontogenetic Development

The frontoparietal network begins to emerge in the perinatal period, with detectable functional connectivity patterns observable in newborns using resting-state (rs-fMRI). Studies have identified local homogeneity within anterior and posterior components of the network, indicating early intrinsic organization that supports basic processes. This initial connectivity exhibits a , as frontal regions from the adult-like frontoparietal network are recruited during stimulus-driven attention tasks in infants as young as 3 months, with no significant age-related changes in activation patterns observed through the first year of life. These findings suggest that the network's foundational architecture is established prenatally or shortly after birth, laying the groundwork for later cognitive functions. During childhood, from approximately ages 4 to 12, the network's structural maturation advances through progressive myelination of key tracts, particularly the superior longitudinal fasciculus (SLF), which interconnects frontal and parietal cortices. Diffusion tensor imaging reveals age-related increases in and axial diffusivity in the SLF, reflecting enhanced microstructural integrity and efficient signal transmission. This myelination trajectory correlates positively with improvements in , such as set-shifting and , where higher SLF integrity explains up to 33% of variance in task performance. Longitudinal data indicate that these changes support the network's growing role in cognitive control, transitioning from rudimentary to more integrated processing. Adolescent refinement of the frontoparietal network occurs around , involving and selective strengthening of connections to optimize efficiency. evidence shows reduced gray matter volume in prefrontal areas concomitant with enhanced functional specificity, mirroring computational models where (e.g., 30-70% removal) bolsters resilience to distractions and refines accuracy. These processes align with pubertal hormonal surges, linking network maturation to metrics of like improved and . A key developmental milestone is the shift from diffuse to focal activation within the frontoparietal network by around age 10, as demonstrated in task-based fMRI studies of cognitive control. In children aged 7-12, early patterns involve broad prefrontal recruitment, which narrows to targeted dorsolateral and ventral prefrontal foci with age, enhancing task efficiency. Recent pediatric neuroimaging in the 2020s, including harmonized rs-fMRI datasets from birth to age 6 and beyond, confirms this progression toward adult-like segregation, with frontoparietal hubs showing increased modularity by late childhood. This refinement marks a critical step in achieving mature network dynamics.

Experience-Dependent Changes

The frontoparietal network exhibits experience-dependent in adulthood through mechanisms such as (LTP) at synapses within the (DLPFC). LTP-like plasticity in the DLPFC can be induced via paired associative stimulation protocols combining (TMS) with peripheral nerve stimulation, leading to enhanced cortical-evoked potentials that persist for at least 30 minutes post-stimulation in healthy adults. This synaptic strengthening supports by facilitating persistent neural activity during cognitive tasks. Similarly, Hebbian learning principles, particularly spike-timing-dependent plasticity (STDP), apply to the posterior parietal cortex (PPC), where temporally correlated inputs from connected regions like the induce LTP or long-term depression (LTD) depending on the timing and cortical state, such as during . These mechanisms enable the network to refine spatial attention and motor planning based on repeated experiences. Cognitive training interventions, such as adaptive tasks targeting , promote structural and functional changes in the frontoparietal network. A of 40 fMRI studies involving 697 participants found that training induces decreased activation in key frontoparietal regions, including the bilateral (IPL), left (SFG), and right (MFG), reflecting improved neural efficiency rather than recruitment of additional areas. For updating tasks like , this efficiency manifests as reduced activity in the IPL and MFG during task execution, with effects persisting across training durations of 10 hours or more; maintenance tasks similarly show decreased SFG activation. Longitudinal studies confirm that 200 minutes of training enhances efficiency in the DLPFC (Brodmann areas 9 and 46) for untrained executive tasks, with changes stable for at least five weeks post-training. In aging adults, the frontoparietal network undergoes gradual disconnection after age 60, characterized by reduced functional connectivity within regions like the rostral and inferior parietal cortex, which correlates with increased distractibility and cognitive decline during -demanding tasks. However, these age-related alterations are partially reversible through interventions like mindfulness meditation, which strengthens intrinsic connectivity in frontoparietal and related networks in cognitively healthy older adults (aged 55-75), leading to improved and after eight weeks of . Dopamine modulation provides a basis for these windows in the DLPFC, where D1-like receptor follows an inverted-U curve to optimize synaptic strengthening during learning. Optimal levels enhance LTP and persistent firing in DLPFC neurons during delays (1-6 seconds), facilitating associative learning in tasks like oculomotor delayed response, while deviations impair . This modulation integrates with frontoparietal dynamics to gate experience-driven adaptations in adulthood.

Clinical Significance

Neurological Disorders

Disruptions to the frontoparietal network are prominent in Alzheimer's disease (AD), where hypoconnectivity between the dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC) has been linked to cognitive decline. Resting-state functional magnetic resonance imaging (rs-fMRI) studies demonstrate that reduced functional connectivity in these regions predicts executive dysfunction and memory impairment in preclinical stages, with early atrophy in frontoparietal hubs exacerbating network inefficiency. For instance, stronger left frontoparietal control network connectivity moderates the impact of amyloid pathology on cognitive trajectories, implying that hypoconnectivity accelerates decline in affected individuals. Recent 2024 rs-fMRI evidence further highlights early volumetric atrophy in DLPFC and PPC as a precursor to widespread hypoconnectivity, correlating with amyloid burden and tau accumulation in mild cognitive impairment transitioning to AD. In stroke and traumatic brain injury (TBI), focal lesions in the superior longitudinal fasciculus (SLF), a key white matter tract connecting frontal and parietal regions, often result in executive deficits such as impaired cognitive control and working memory. SLF damage disrupts frontoparietal structural integrity, leading to reduced functional coupling and persistent attentional lapses, as observed in post-stroke patients with lesions overlapping these pathways. Recovery mechanisms involve compensatory rerouting through alternative pathways, including ipsilateral uncinate fasciculus engagement, which supports partial restoration of executive functions over months post-injury. In TBI cohorts, longitudinal diffusion tensor imaging reveals that SLF lesion severity inversely correlates with recovery rates, but neuroplastic adaptations in spared frontoparietal segments facilitate rerouting and mitigate long-term deficits. Parkinson's disease features dopamine depletion that diminishes frontoparietal network efficiency, contributing to cognitive inflexibility beyond motor symptoms. Nigrostriatal dopamine loss disrupts oscillatory dynamics, with elevated -band oscillations (13-30 Hz) reflecting impaired information flow between prefrontal and parietal nodes, as measured via in unmedicated patients. This inefficiency manifests as heightened network integration during dopamine-depleted states, correlating with slower executive processing and reduced adaptability in task-switching paradigms. therapy partially normalizes these beta oscillations, enhancing frontoparietal synchronization and alleviating associated cognitive burdens. Emerging 2024-2025 studies underscore the of frontoparietal in preserving cognitive amid hypoperfusion during aging. analyses show that maintained functional and structural in this buffers against perfusion deficits in older adults, sustaining performance despite reduced cerebral blood flow in frontal and parietal regions. For example, in pre-symptomatic neurodegenerative contexts akin to aging trajectories, predicts cognitive even with concurrent and hypoperfusion, highlighting a protective against decline. These findings suggest targeted interventions preserving frontoparietal could mitigate age-related vulnerabilities.

Psychiatric Conditions

The frontoparietal network (FPN) exhibits aberrant patterns in several psychiatric conditions, where structural integrity is often preserved but functional dysregulation contributes to cognitive and emotional impairments. These alterations highlight the network's role in cognitive control and , with disruptions manifesting as imbalances in resting-state hyperconnectivity versus task-related hypoactivation. Such are particularly evident in , attention-deficit/hyperactivity disorder (ADHD), anxiety disorders, and (MDD), underscoring the FPN's vulnerability in psychiatric syndromes. In , resting-state (fMRI) studies reveal hyperconnectivity within the left FPN, particularly increased connectivity between key nodes, which may reflect inefficient network segregation and contribute to disorganized thought processes. Conversely, during cognitive tasks such as paradigms, patients show hypoactivation in fronto-parietal regions, including the (DLPFC) and posterior parietal cortex (PPC), correlating with pronounced deficits that impair daily functioning. This task-induced hypoactivation is linked to reduced effective connectivity from prefrontal to parietal areas, exacerbating . In ADHD, developmental neuroimaging indicates delayed maturation of the FPN, with prolonged inefficiency in DLPFC recruitment during attention-demanding tasks, leading to sustained attentional lapses. Recent 2025 studies on dynamic functional connectivity (dFC) further demonstrate instability in FPN temporal patterns, characterized by reduced spatial and temporal stability in dlPFC and PPC nodes, which aligns with symptom severity and suggests underlying volatility as a . In anxiety disorders, such as and , FPN hypoactivation and altered connectivity have been associated with excessive worry and attentional biases toward threat. Resting-state studies show reduced FPN-DMN anticorrelation, leading to impaired cognitive control over intrusive thoughts, while task-based fMRI reveals inefficient recruitment of DLPFC and PPC during emotion regulation tasks. These disruptions contribute to heightened amygdala-FPN coupling, exacerbating anxiety symptoms. Major depressive disorder is associated with blunted responses in frontoparietal regions during and cognitive tasks, reflecting hypoconnectivity within the FPN that impairs goal-directed . These attenuated activations correlate with severity, a core symptom involving diminished motivational drive. Emerging 2025 research highlights alterations in FPN functional connectivity in mood disorders, with implications for reduced . Therapeutic interventions, such as targeting FPN dynamics, show promise in normalizing these patterns to alleviate symptoms.

History and Nomenclature

Discovery and Evolution

The conceptualization of the frontoparietal network emerged in the late 1980s through (PET) studies investigating systems, where Michael Posner and colleagues identified distinct neural circuits for alerting, orienting, and executive control, with key involvement of frontal and parietal regions in the latter two functions. These foundational works, including analyses of blood flow changes during spatial tasks, laid the groundwork for recognizing a distributed spanning prefrontal and posterior parietal cortices as central to attentional . Advancements in the 2000s were propelled by (fMRI), which enabled finer-grained mapping of task-related activations. A pivotal milestone came in when Maurizio Corbetta and Gordon Shulman distinguished the dorsal frontoparietal network, involved in top-down goal-directed , from the ventral counterpart, which handles stimulus-driven reorienting to salient events, collectively framing the system as a task-positive network essential for and spatial . This dorsal-ventral dichotomy, supported by meta-analyses of fMRI data, highlighted the network's modular yet interactive architecture in modulating attentional priorities. Parallel to task-based studies, the mid-2000s saw the identification of the frontoparietal network as an intrinsic network using resting-state fMRI, highlighting its role in spontaneous . Theoretical evolution accelerated in 2010 with John Duncan's introduction of the multiple-demand framework, positing the frontoparietal as a domain-general system that flexibly supports diverse cognitive demands such as , , and problem-solving across tasks. This perspective shifted emphasis from attention-specific roles to broader intelligent , integrating evidence from electrophysiology and human imaging to underscore the network's adaptive recruitment in fluid tests. By the 2020s, models increasingly incorporated dynamic fluctuations, viewing the network not as static but as undergoing state-dependent reconfiguration during cognitive engagement. Methodologically, research transitioned from static connectivity analyses—capturing average correlations—to dynamic approaches around 2015-2025, using sliding-window techniques and to reveal time-varying interactions within the frontoparietal network, as exemplified in studies of executive function demands. This evolution has illuminated transient coupling with other systems, enhancing understanding of the network's role in behavioral .

Terminology Variations

The frontoparietal network (FPN) is the most widely used term in contemporary literature to describe a distributed set of cortical regions involved in higher-order cognitive processes, often encompassing lateral prefrontal and parietal areas. This designation gained prominence through intrinsic functional analyses, where it was formalized as a core system for . A closely related primary term is the central executive network (CEN), introduced in the influential 2011 parcellation of seven intrinsic networks by et al., which positioned the CEN as a domain-general controller distinct from sensory or default mode systems. Alternative terminologies reflect nuanced emphases on the network's functional properties. The multiple-demand network (MDN) highlights its task-general activation pattern, where regions exhibit increased BOLD signals across diverse cognitive demands such as , , and , as defined in foundational studies extending beyond traditional executive frameworks. Similarly, the executive control network (ECN) is frequently employed interchangeably with FPN or CEN, particularly in research on regulatory processes like inhibition and flexibility, underscoring its role in overriding habitual responses. Nomenclature debates persist regarding boundaries and distinctions from adjacent systems, notably the cingulo-opercular network (CON), which shares some but is differentiated by its involvement in sustained monitoring and error detection rather than transient . Recent reviews have advanced efforts by standardizing network definitions through multi-modal , addressing inconsistencies in parcellation schemes and promoting unified terminology for cross-study comparability. Historically, late 1990s and early 2000s literature often referred to the network as an "attention network" due to its prominent role in visuospatial orienting and oculomotor control, as evidenced in studies of attentional shifts. By the mid-2000s, terminology evolved to "cognitive control network" to capture its broader involvement in goal-directed behavior and response inhibition, reflecting advances in functional MRI that revealed domain-general recruitment. This shift marked a transition from narrow attentional models to integrative views of orchestration.