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Generalized anxiety disorder

Generalized anxiety disorder (GAD) is a prevalent mental health condition defined by excessive, persistent anxiety and worry about a wide range of everyday activities or events, such as work, health, or finances, that occurs on more days than not for at least six months.^[1] This worry is often difficult to control and disproportionate to the actual likelihood or impact of the feared events, distinguishing it from normal stress responses.^[2] Accompanying symptoms typically include restlessness or feeling on edge, fatigue, difficulty concentrating or mind going blank, irritability, muscle tension, and sleep disturbances, all of which must cause significant distress or impairment in social, occupational, or other key areas of functioning.^[3] GAD affects an estimated 2.7% of U.S. adults in the past year, equating to about 7 million people, with women approximately twice as likely to experience it as men.^[4] Lifetime prevalence is estimated at around 5% of the population, and the disorder can onset at any age but most commonly emerges in early to mid-adulthood. It frequently co-occurs with other mental health conditions, such as major depressive disorder (in about 59% of cases) or substance use disorders, complicating diagnosis and management.^[5] The development of GAD arises from a complex interplay of genetic, biological, environmental, and psychological factors, though no single cause has been identified. Genetic predisposition plays a role, with individuals having a family history of anxiety disorders facing elevated risk; brain imaging studies suggest differences in areas regulating fear and emotion, alongside imbalances in neurotransmitters like serotonin and norepinephrine.^[6] Environmental triggers, including chronic stress, trauma, or adverse childhood experiences, can precipitate or exacerbate symptoms, particularly in those with vulnerable temperaments such as perfectionism or negative bias.^[1] Diagnosis follows criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), requiring the anxiety to not be attributable to substance use, medical conditions, or other psychiatric disorders, and ruling out similar conditions like panic disorder through clinical assessment.^[7] Treatment is multifaceted and highly effective, with first-line options including cognitive behavioral therapy (CBT), which helps reframe worry patterns, and pharmacotherapy such as selective serotonin reuptake inhibitors (SSRIs) like sertraline or serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine.^[8] Benzodiazepines may provide short-term relief for acute symptoms but are used cautiously due to dependency risks, while lifestyle interventions like exercise and mindfulness support long-term management.^[6]

Signs and symptoms

Core psychological features

Generalized anxiety disorder (GAD) is fundamentally characterized by excessive and uncontrollable worry about a wide range of everyday events or activities, such as work performance, health concerns, or family issues, occurring more days than not for at least six months.^[3] This worry is often unrealistic and disproportionate to the actual likelihood or impact of the events, leading individuals to anticipate the worst outcomes even in minor situations.^[7] For instance, a person with GAD might persistently ruminate on potential financial setbacks or minor health symptoms, experiencing a pervasive sense of impending doom that dominates their thoughts.^[2] A core feature is the difficulty in controlling this worry, which distinguishes GAD from typical anxiety responses.^[3] Individuals often report an inability to set aside anxious thoughts, resulting in overthinking and obsessive planning for hypothetical disasters.^[2] This uncontrollability is frequently accompanied by associated psychological symptoms, including restlessness or feeling on edge, fatigue, difficulty concentrating or mind going blank, and irritability.^[7] These mental manifestations create a cycle where worry impairs cognitive focus and emotional regulation, making routine tasks feel overwhelming.^[7] Unlike normal anxiety, which is transient and tied to specific stressors, the worry in GAD is pervasive, generalized across multiple domains, and not limited to particular triggers like phobias or trauma.^[7] It interferes significantly with daily mental well-being, as the persistent apprehension about uncertain future events—such as minor decisions or everyday uncertainties—leads to chronic emotional distress rather than adaptive caution.^[2] This differentiation highlights GAD as a disorder of sustained cognitive hypervigilance, where worry becomes a default mode of processing rather than an occasional response.^[7]

Associated physical manifestations

Individuals with generalized anxiety disorder (GAD) often experience a range of somatic symptoms that accompany excessive worry, distinguishing the condition from transient anxiety. These physical manifestations arise from sustained autonomic arousal and muscular hyperactivity, frequently presenting as chronic complaints without identifiable acute triggers.^[7] Common physical signs include muscle tension, which may manifest as jaw clenching, shoulder stiffness, or tension headaches, alongside persistent fatigue that hinders daily energy levels. Gastrointestinal disturbances, such as nausea, diarrhea, or irritable bowel-like symptoms, are also prevalent, often exacerbated by ongoing stress. Additional manifestations encompass excessive sweating, trembling or shaking, and sleep disturbances, including insomnia or non-restorative sleep, which further perpetuate the cycle of anxiety.^[7]^[2]^[9] Autonomic arousal features during episodes of heightened worry can involve increased heart rate or palpitations, shortness of breath, and sensations of dizziness or lightheadedness, reflecting sympathetic nervous system overactivation. These symptoms typically occur in the context of psychological worry but emphasize the bodily dimension of GAD.^[7]^[10] The chronic nature of these physical symptoms in GAD is defined by their persistence for at least six months, often without external precipitants, leading individuals to worry about the symptoms themselves and reinforcing the disorder's vicious cycle. Muscle tension and restlessness are among the most frequently reported somatic complaints.^[7]

Impact on daily functioning

Generalized anxiety disorder (GAD) significantly disrupts occupational functioning through symptoms such as excessive worry, difficulty concentrating, and fatigue, leading to reduced productivity and increased absenteeism.^[1] Individuals with GAD often experience challenges in maintaining employment, as persistent anxiety impairs task completion and decision-making at work, resulting in lower overall job performance.^[11] For instance, studies indicate that GAD predicts work impairment even after accounting for physical health factors, contributing to higher rates of missed workdays.^[12] In social and relational domains, GAD fosters avoidance of social situations and irritability, which strain interpersonal relationships and promote isolation.^[1] People affected may withdraw from family and friends due to constant nervousness or fear of judgment, leading to diminished social support networks and heightened relational conflicts.^[13] Research shows that these impacts manifest as notable impairments in social functioning, comparable to those seen in other anxiety disorders.^[14] On a personal level, GAD hinders routine daily tasks through procrastination, impaired decision-making, and overall fatigue, substantially lowering quality of life.^[1] Affected individuals report difficulties with self-care activities, such as managing household responsibilities or personal goals, often measured by reduced scores on quality-of-life scales like the Quality of Life Inventory (QOLI), where GAD patients average 0.73 compared to 2.6 for non-anxious adults.^[14] This pervasive interference extends to sleep disturbances and physical tension, further eroding personal well-being and autonomy.^[13] Long-term, GAD elevates healthcare utilization and imposes a considerable economic burden, with affected individuals incurring median annual medical costs of $2,375 versus $1,448 for those without the disorder.^[15] The condition is linked to heightened disability, with studies reporting impairments in role functioning that parallel those of major depression.^[11] Globally, anxiety disorders like GAD contribute to productivity losses and increased service demands, affecting an estimated 4.4% of the population and underscoring their societal impact.^[13]

Causes

Genetic and familial influences

Generalized anxiety disorder (GAD) exhibits a moderate genetic component, with twin studies estimating heritability at approximately 30-40% for liability to the disorder, though recent longitudinal research indicates heritability of stable GAD symptoms up to 60%.^[16]^[17] Meta-analyses of family and twin data further support a genetic heritability of around 31.6%, indicating that genetic factors contribute substantially but not exclusively to GAD risk.^[16] Familial aggregation is evident, as first-degree relatives of individuals with GAD face a 2- to 6-fold increased risk compared to the general population, with odds ratios around 3.1 in some cohorts.^[18] Adoption studies reinforce this genetic transmission, showing that cross-generational patterns of anxiety disorders persist beyond shared rearing environments, with both genetic and environmental rearing effects contributing to inheritance.^[19] Early candidate gene studies have identified modest associations with polymorphisms in genes involved in neurotransmitter systems and neurotrophic factors, including the catechol-O-methyltransferase gene (COMT), the serotonin transporter gene (SLC6A4), and the brain-derived neurotrophic factor gene (BDNF); however, these have limited replicability and have been largely superseded by polygenic models.^[20]^[21] No single gene is causative for GAD, underscoring its complex, multifactorial etiology.^[20] Advancing beyond candidate genes, genome-wide association studies (GWAS) from 2023, 2024, and 2025 have revealed multiple genetic loci associated with GAD and related anxiety traits, enabling the development of polygenic risk scores that capture cumulative small-effect variants.^[22]^[23] For instance, a 2024 GWAS in a large veteran cohort identified novel loci linked to major anxiety disorders, including GAD, with polygenic scores showing correlations to broader anxiety phenotypes and comorbid conditions.^[22] A 2025 GWAS meta-analysis of generalised anxiety symptom severity identified 82 independent variants within 76 loci, 41 novel for anxiety, with SNP-based heritability of 5.9%.^[24] These findings highlight GAD's polygenic architecture, where hundreds of variants across the genome contribute to risk.

Environmental and psychosocial factors

Environmental and psychosocial factors play a significant role in the onset and exacerbation of generalized anxiety disorder (GAD), often interacting with individual vulnerabilities to heighten worry and physiological arousal. Childhood adversity, including trauma, abuse, or neglect, substantially elevates the risk of developing GAD in adulthood, with meta-analyses indicating odds ratios ranging from 1.7 to 3.16 for various forms of maltreatment such as emotional or sexual abuse.^[25]^[26] These experiences disrupt normal development by altering the stress response system, particularly through dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, leading to heightened sensitivity to stressors and persistent anxiety proneness.^[27]^[28] Chronic stressors in adulthood, such as financial strain, work-related pressures, and caregiving responsibilities, further contribute as precipitating or maintaining factors for GAD. Financial difficulties have been linked to increased psychological distress, with particularly strong associations to anxiety symptoms due to ongoing uncertainty and resource scarcity.^[29] Similarly, high job demands and low control in the workplace are independent risk factors for GAD, amplifying rumination and autonomic hyperarousal.^[30] Caregiving roles, often involving prolonged emotional and physical demands, heighten anxiety risk through cumulative burden, with informal caregivers showing elevated rates of anxiety disorders compared to non-caregivers.^[31] Psychosocial models, particularly attachment theory, provide a framework for understanding how early relational patterns influence GAD vulnerability. Insecure attachment styles, stemming from inconsistent or unresponsive caregiving, are associated with heightened worry proneness and difficulty regulating emotions, increasing the likelihood of anxiety disorders across the lifespan.^[32]^[33] These patterns foster a cognitive bias toward threat perception, where individuals anticipate rejection or harm, perpetuating chronic anxiety. Recent global events have underscored the impact of acute environmental disruptions on GAD. The COVID-19 pandemic, with its isolation, economic uncertainty, and health threats, triggered a 25% global increase in anxiety prevalence, including new-onset cases of GAD, as reported by the World Health Organization.^[34] This surge highlights how widespread psychosocial stressors can rapidly elevate disorder rates, often compounding preexisting vulnerabilities.

Role of problematic digital media use

Problematic digital media use, characterized by excessive and compulsive engagement with online platforms, contributes to the development and exacerbation of generalized anxiety disorder (GAD) through several behavioral mechanisms. Doomscrolling, the habitual consumption of negative news content on social media, heightens existential anxiety by fostering a pervasive sense of threat and uncertainty about global events, thereby amplifying chronic worry—a core feature of GAD.^[35] Similarly, social media comparison, particularly upward comparisons on platforms like Instagram where users view idealized images, leads to diminished self-esteem and increased anxiety symptoms by intensifying concerns about personal inadequacy and social standing.^[36] Cyberbullying, often occurring via messaging apps or social networks, further elevates GAD risk by inducing persistent fear and hypervigilance, resulting in higher rates of anxiety among adolescent victims compared to non-victims.^[37] Recent studies from 2023–2024 underscore these links, particularly in adolescents. A meta-analysis of over 250,000 participants found a moderate positive correlation (r = 0.388) between problematic social networking use and generalized anxiety symptoms, with stronger associations during periods of heightened global uncertainty like the COVID-19 pandemic.^[38] Systematic reviews confirm that problematic media use predicts anxiety symptoms more strongly in younger adolescents, with females showing elevated vulnerability.^[39] Regarding screen time, U.S. data indicate that teenagers averaging 4 or more hours daily are over twice as likely to report anxiety symptoms (27.1%) compared to those with less than 4 hours (12.3%), equating to approximately a 1.5–2-fold increased risk for GAD-like manifestations in this group.^[40] Specific platform features, such as constant news alerts on apps like Twitter or TikTok, exacerbate uncertainty intolerance—a key vulnerability in GAD—by delivering unfiltered streams of alarming information that perpetuate rumination and anticipatory anxiety.^[41] As a preventive strategy, digital detox interventions, involving temporary reductions in screen time, have shown promise in alleviating anxiety symptoms among youth by disrupting these cycles, though long-term efficacy requires further research.^[42]

Pathophysiology

Neurobiological mechanisms

Generalized anxiety disorder (GAD) is characterized by dysregulation of key neurotransmitter systems, including the inhibitory gamma-aminobutyric acid (GABA), serotonin, and norepinephrine pathways.^[43]^[5] GABA serves as the primary inhibitory neurotransmitter in the central nervous system, modulating neuronal excitability in regions such as the amygdala and prefrontal cortex; its reduced function in GAD leads to unchecked anxiety signals and heightened threat perception.^[43]^[44] Serotonin dysregulation impairs mood stabilization and cognitive control over worry, while norepinephrine imbalances contribute to excessive arousal and vigilance, as evidenced by altered receptor densities and signaling in affected individuals.^[45]^[46] The hypothalamic-pituitary-adrenal (HPA) axis demonstrates hyperactivity in GAD, characterized by exaggerated release of cortisol in response to even mild perceived threats, fostering a state of chronic stress.^[47]^[48] This overactivation disrupts negative feedback loops, resulting in sustained glucocorticoid elevation that exacerbates neuronal vulnerability and impairs adaptive stress responses.^[49] Studies indicate that such HPA dysregulation correlates with the persistence of GAD symptoms, independent of acute stressors.^[50] Recent epigenome-wide association studies have revealed distinct DNA methylation patterns in genes linked to anxiety, particularly FKBP5, which regulates glucocorticoid receptor sensitivity and HPA axis function.^[51] A 2024 analysis identified FKBP5 methylation variations associated with altered emotion processing and prefrontal-limbic connectivity related to trait anxiety.^[52] A multi-ancestry epigenome-wide association study of GAD was published as a preprint in November 2025.^[53] These epigenetic modifications may mediate environmental influences on genetic predispositions, amplifying neurobiological vulnerability.^[54] Inflammatory processes also play a role in GAD pathogenesis, with elevated levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) observed in patients compared to healthy controls.^[55]^[56] Meta-analyses confirm that IL-6 elevations are specific to GAD and correlate with the severity of somatic symptoms, including muscle tension and fatigue, potentially through cytokine-induced neuroinflammation.^[57]^[58] This inflammatory profile links peripheral immune activation to central nervous system changes, contributing to the disorder's multifaceted presentation.^[59]

Evolutionary perspectives

From an evolutionary standpoint, generalized anxiety disorder (GAD) can be understood through the "smoke detector principle," which posits that the human anxiety system is calibrated to err on the side of overreacting to potential threats rather than underreacting, as the costs of missing a real danger in ancestral environments far outweighed the costs of false alarms.^[60] This principle, originally articulated by Nesse, explains why worry in GAD—characterized by persistent, diffuse concerns—may represent an exaggerated but adaptive vigilance mechanism for detecting multifaceted threats like predators, social conflicts, or resource scarcity in the environment of evolutionary adaptation.^[61] In GAD, this leads to chronic hypervigilance, where the threshold for anxiety activation is lowered, prioritizing survival over efficiency.^[62] The mismatch hypothesis further elucidates GAD's persistence, suggesting that traits like heightened worry were beneficial in high-threat ancestral settings but become maladaptive in modern, low-threat environments with abundant resources and reduced immediate dangers.^[62] This environmental discord amplifies once-useful anxiety responses, turning them into pathological worry when contemporary stressors—such as abstract uncertainties in work or relationships—trigger the system without resolution.^[61] Supporting evidence comes from cross-cultural studies indicating higher GAD prevalence in urban areas compared to rural ones; for instance, in Latin America, urban older adults showed nearly three times the odds of anxiety disorders versus rural counterparts, attributed to denser social pressures and information overload mimicking but not matching ancestral threats.^[63] Similarly, meta-analyses in China report urban non-specific anxiety disorder rates at 7.60‰ versus 4.66‰ in rural areas, reinforcing the role of urban-rural environmental mismatches.^[64] Criticisms of these evolutionary accounts highlight their potential overemphasis on universal adaptations, which may overlook cultural variations in anxiety expression and regulation.^[62] For example, among the Chewong people of Malaysia, fearfulness is openly endorsed as a social norm rather than pathologized, suggesting that what is labeled GAD in Western contexts might reflect culturally specific interpretations of adaptive caution rather than inherent dysfunction.^[62] Additionally, evolutionary models face challenges in empirically distinguishing adaptive traits from harmful dysfunctions, as diagnostic thresholds for GAD may artificially separate normative worry from disorder without accounting for contextual fitness benefits in diverse environments.^[61]

Neuroimaging and biomarker findings

Neuroimaging studies have consistently identified hyperactivity in key brain regions associated with emotion processing and regulation in individuals with generalized anxiety disorder (GAD). Functional magnetic resonance imaging (fMRI) research reveals increased activation in the amygdala, insula, and prefrontal cortex during tasks involving emotional stimuli, reflecting heightened threat detection and emotional reactivity.^[65] For instance, task-based fMRI demonstrates bilateral insula and medial prefrontal cortex hyperactivity in response to anxiety-provoking cues. Additionally, structural and functional analyses show reduced functional connectivity within the default mode network (DMN), which is implicated in self-referential thinking and rumination, contributing to the persistent worry characteristic of GAD. Studies have reported diminished ventromedial prefrontal cortex-insula connectivity, underscoring disrupted emotion regulation circuits.^[66] Recent investigations confirm DMN disruptions in limbic-prefrontal interactions, distinguishing GAD patterns from healthy controls.^[67] Recent advances in fMRI and electroencephalography (EEG) have further elucidated alterations in fear circuitry in GAD. Recent fMRI studies highlight disruptions in limbic-default mode network circuits, with reduced connectivity between the amygdala and prefrontal regions during threat processing, compared to controls.^[68] EEG evidence supports this, showing altered functional connectivity patterns that enable machine learning-based detection of GAD with high accuracy, emphasizing aberrant neural oscillations in fear-related networks.^[69] These findings build on research indicating that GAD patients exhibit marked reductions in limbic-prefrontal circuit dynamics, potentially reflecting impaired fear extinction and heightened vigilance.^[67] Such evidence positions these techniques as valuable research tools for probing GAD-specific neural signatures. Emerging biomarkers offer objective measures to complement neuroimaging in GAD assessment. Salivary cortisol levels are elevated in GAD, particularly in late-life cases, serving as a noninvasive indicator of hypothalamic-pituitary-adrenal axis dysregulation and anxiety severity. Heart rate variability (HRV), a marker of autonomic nervous system function, is reduced in anxiety disorders including GAD, with 2024 meta-analyses confirming lower vagally-mediated HRV as a transdiagnostic biomarker linked to symptom persistence.^[70] As of 2025, wearable technologies integrating HRV and cortisol monitoring via biosensors have shown promise for real-time GAD symptom tracking, with AI-enhanced devices predicting anxiety episodes through physiological data fusion.^[71] These biomarkers aid in differentiating GAD from controls but require validation for clinical use. Despite these insights, neuroimaging and biomarker findings in GAD are limited by significant heterogeneity, often attributable to comorbidities such as depression or other anxiety disorders, which confound circuit-specific interpretations. Reviews emphasize that variability in sample characteristics and methodological differences across studies contributes to inconsistent results, hindering biomarker reliability. Addressing this heterogeneity through larger, stratified cohorts remains essential for advancing GAD diagnostics.

Diagnosis

DSM-5 diagnostic criteria

The diagnosis of generalized anxiety disorder (GAD) in the DSM-5 requires the presence of excessive anxiety and worry occurring more days than not for at least 6 months, pertaining to a number of events or activities, such as work or school performance.^[3] The individual must find it difficult to control this worry.^[3] Additionally, the anxiety and worry must be associated with three or more of the following six symptoms, with at least some symptoms present for more days than not over the past 6 months (only one symptom is required in children): restlessness or feeling keyed up or on edge; being easily fatigued; difficulty concentrating or mind going blank; irritability; muscle tension; and sleep disturbance (difficulty falling or staying asleep, or restless, unsatisfying sleep).^[3] These symptoms must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.^[3] The disturbance cannot be attributable to the physiological effects of a substance (e.g., a drug of abuse or medication) or another medical condition (e.g., hyperthyroidism).^[3] Furthermore, the anxiety and worry are not better explained by another mental disorder, such as panic disorder (worry about panic attacks), social anxiety disorder (fear of negative evaluation), obsessive-compulsive disorder (obsessions about contamination), separation anxiety disorder (excessive fear of separation), posttraumatic stress disorder (reliving traumatic events), somatic symptom disorder (disproportionate worry about physical symptoms), illness anxiety disorder (preoccupation with having a serious illness), or schizophrenia spectrum disorders (delusional content).^[3] These exclusion criteria ensure that GAD is distinguished from other conditions that may present with similar features.^[10] Severity for GAD is specified based on clinician judgment of the number of associated symptoms beyond the minimum required (three in adults) and the degree of functional impairment, categorized as mild (few symptoms beyond minimum, mild impairment), moderate (several symptoms, moderate impairment), or severe (many symptoms, severe impairment).^[72] The DSM-5 provides a supplementary Severity Measure for GAD—Adult, a 10-item self-report scale assessing symptom frequency over the past week (scored 0–4 per item, total 0–40), which yields an average score interpreted as none (0), mild (1), moderate (2), severe (3), or extreme (4) to guide severity rating and treatment monitoring.^[72] The DSM-5-TR (2022) retains the core diagnostic criteria for GAD but includes updated descriptive text emphasizing cultural considerations in the expression and reporting of worry, such as somatic manifestations in some cultural groups or variations in what constitutes "excessive" worry based on sociocultural norms.^[73]^[74]

ICD-11 criteria and differential diagnosis

The International Classification of Diseases, 11th Revision (ICD-11), classifies generalized anxiety disorder (GAD) under code 6B00 within the anxiety and fear-related disorders chapter. Essential features include prominent anxiety or excessive worry about multiple everyday events or activities, such as work, health, or family, that persists for at least several months, occurring on more days than not, and is difficult to control. This worry is typically disproportionate to the actual risk and is accompanied by additional cognitive or somatic symptoms, including restlessness, fatigue, difficulty concentrating, irritability, muscle tension, sleep disturbance, or autonomic overactivity such as palpitations or sweating. Unlike previous classifications, ICD-11 adopts a prototypic approach without a fixed symptom count, focusing instead on the pervasive and generalized nature of the anxiety across situations. Avoidance behaviors, such as avoiding anxiety-provoking situations or excessive reassurance-seeking, may be present but are not required for diagnosis. Symptoms must cause significant distress or impairment in personal, family, social, educational, occupational, or other important areas of functioning, and the disorder cannot be better explained by another mental, medical, or substance-related condition.^[75] Key differences from the DSM-5 criteria include ICD-11's more flexible duration requirement of "several months" rather than a strict six months, and its broader emphasis on general apprehensiveness or free-floating anxiety without mandating a specific number of accompanying symptoms (DSM-5 requires three out of six). ICD-11 also explicitly incorporates manifestations of sympathetic arousal, such as autonomic symptoms, as core accompaniments to worry, providing a less symptom-checklist-oriented framework to enhance clinical utility across diverse global settings.^[75] Differential diagnosis in ICD-11 distinguishes GAD from other conditions based on its chronic, non-specific, and generalized pattern. Unlike panic disorder, GAD lacks recurrent, unexpected panic attacks and instead features persistent apprehensiveness without discrete episodes. It differs from social anxiety disorder, where fears are confined to social evaluation or performance situations, and from specific phobia, which involves circumscribed fears of particular objects or activities. GAD is also differentiated from adjustment disorder by its longer duration and lack of direct linkage to an identifiable stressor, as well as from health anxiety disorder by extending beyond health-related concerns to multiple domains. Additionally, it excludes cases better accounted for by obsessive-compulsive disorder (no obsessions or compulsions), post-traumatic stress disorder (no trauma linkage), or depressive disorders (anxiety predominates over low mood or anhedonia).^[75] The 2024 release of the Clinical Descriptions and Diagnostic Requirements (CDDR) for ICD-11 mental disorders reinforces these criteria with detailed guidelines, placing heightened emphasis on functional impairment to improve applicability in low-resource and culturally diverse settings worldwide.^[76]

Treatment

Psychotherapy approaches

Psychotherapy is a cornerstone of treatment for generalized anxiety disorder (GAD), with evidence-based approaches emphasizing the modification of maladaptive thought patterns, emotional regulation, and behavioral responses to chronic worry. Among these, cognitive behavioral therapy (CBT) stands out as the most extensively studied and recommended first-line intervention, typically involving 12-16 sessions focused on identifying and challenging cognitive distortions, such as catastrophic thinking about uncertain future events, and incorporating relaxation techniques like progressive muscle relaxation. Meta-analyses indicate that CBT achieves response rates of 50-60% in reducing GAD symptoms, with sustained effects up to 12 months post-treatment, outperforming waitlist controls and showing moderate effect sizes (Hedges' g ≈ 0.8). Acceptance and commitment therapy (ACT), a third-wave CBT variant, shifts emphasis from symptom reduction to fostering psychological flexibility through mindfulness practices, defusion from worrisome thoughts, and alignment with personal values. ACT is particularly effective for GAD patients with high intolerance of uncertainty, a core feature of the disorder, by encouraging acceptance of anxiety rather than avoidance. Randomized controlled trials demonstrate ACT's efficacy, with symptom reductions comparable to traditional CBT (effect size d ≈ 0.7) and improvements in quality of life persisting at 6-month follow-up. A 2019 meta-analysis of ACT for anxiety disorders, including GAD, reported moderate to large effects on worry severity (g = 0.82), supporting its use as an alternative or adjunct to CBT. Other psychotherapeutic modalities include psychodynamic therapy, which explores unconscious conflicts and early relational patterns potentially underlying persistent anxiety, and exposure-based therapies, which systematically confront avoided worry triggers to diminish anticipatory anxiety. Short-term psychodynamic psychotherapy has shown promise in small trials for GAD, with effect sizes similar to CBT for symptom relief (d = 0.6-0.9), though larger studies are needed to confirm long-term benefits. These modalities are generally less empirically supported than CBT or ACT but offer options for patients unresponsive to standard cognitive techniques. Psychotherapies for GAD can be delivered in various formats to enhance accessibility, including individual sessions for personalized focus, group settings that leverage peer support to normalize experiences, and online or computerized CBT variants, which maintain efficacy comparable to in-person delivery (effect size differences <0.2). Internet-delivered CBT, for instance, has demonstrated 55% response rates in meta-analyses, with high completion rates due to its flexibility. Overall, psychotherapy's success often depends on therapist expertise and patient engagement, with combined approaches sometimes used adjunctively to pharmacotherapy for optimal outcomes.

Pharmacological interventions

Pharmacological interventions represent a cornerstone of treatment for generalized anxiety disorder (GAD), with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) serving as first-line options due to their favorable efficacy and tolerability profiles.^[77] These agents, including escitalopram (an SSRI) and venlafaxine (an SNRI), are FDA-approved for GAD and work by enhancing serotonergic and noradrenergic neurotransmission to alleviate excessive worry and autonomic symptoms.^[77] Clinical guidelines recommend initiating treatment at low doses, titrating upward over 1-2 weeks, with therapeutic effects typically emerging within 2-4 weeks and optimal response by 8-12 weeks.^[78] Meta-analyses indicate response rates (defined as ≥50% reduction in Hamilton Anxiety Rating Scale scores) of 50-60% and remission rates (minimal residual symptoms) of approximately 35-40% with these medications compared to 20% with placebo.^[79] When combined with psychotherapy, such as cognitive behavioral therapy, remission rates can improve further, supporting an integrated approach for many patients.^[77] Benzodiazepines, exemplified by lorazepam and clonazepam, provide rapid symptom relief for acute exacerbations of GAD due to their enhancement of gamma-aminobutyric acid (GABA) activity at GABA-A receptors.^[77] However, they are reserved for short-term use (typically 2-4 weeks) owing to substantial risks of tolerance, physical dependence, and withdrawal symptoms upon discontinuation, which can mimic or exacerbate anxiety.^[80] Long-term benzodiazepine use is associated with cognitive impairment, increased fall risk in older adults, and higher potential for misuse, particularly in patients with comorbid substance use disorders; thus, guidelines advise against them as monotherapy.^[81] Tapering should occur gradually, often over weeks to months, under close supervision to minimize rebound anxiety and seizure risk.^[80] For patients with inadequate response to first-line agents, augmentation strategies include buspirone, a 5-HT1A partial agonist FDA-approved for GAD, which can enhance SSRI/SNRI effects without sedation or dependence liability.^[77] Dosed at 15-60 mg daily in divided administrations, buspirone shows modest efficacy as an adjunct, particularly for residual anxiety, with onset delayed by 2-4 weeks.^[82] Pregabalin, a calcium channel modulator, is utilized off-label in the United States for GAD somatic symptoms despite lacking FDA approval for this indication (though approved in the European Union); it demonstrates rapid anxiolytic effects comparable to benzodiazepines in trials, with Hamilton Anxiety Rating Scale reductions of about 2.8 points greater than placebo.^[78] Common adverse effects across these interventions necessitate vigilant monitoring to optimize adherence and safety. SSRIs and SNRIs frequently cause sexual dysfunction (affecting 20-30% of users), nausea, and modest weight gain, while SNRIs like venlafaxine may elevate blood pressure, requiring periodic checks.^[78] Benzodiazepines contribute to drowsiness and coordination issues, and pregabalin to dizziness and somnolence (leading to higher dropout rates in some studies).^[77] Buspirone has a benign profile, primarily causing mild dizziness or headache. Treatment continuation for at least 6-12 months post-remission is advised to prevent relapse, with slow tapering thereafter.^[83]

Lifestyle modifications and complementary therapies

Lifestyle modifications play a crucial role in managing generalized anxiety disorder (GAD) by promoting overall well-being and reducing symptom severity through accessible, non-pharmacological means. Regular aerobic exercise, such as walking or cycling for at least 150 minutes per week, has been shown to significantly alleviate anxiety symptoms in individuals with GAD, with meta-analyses indicating a moderate effect size of approximately 0.29 in symptom reduction compared to no treatment. A 2024 review of exercise interventions further supports that aerobic activities lead to notable decreases in GAD symptoms, including improvements in Hospital Anxiety and Depression Scale (HADS-A) scores by around 4 points. Dietary adjustments complement these efforts; avoiding caffeine, which can exacerbate anxiety due to its stimulant effects, is recommended, as higher intake is associated with increased anxiety levels across observational and experimental studies. Adopting a balanced diet rich in fruits, vegetables, and omega-3 fatty acids may also mitigate symptoms, with scoping reviews linking such patterns to lower anxiety prevalence. Mindfulness practices and yoga offer evidence-based complementary approaches for GAD, particularly for mild cases, by enhancing emotional regulation and reducing worry. Randomized controlled trials (RCTs) demonstrate that mindfulness-based interventions, such as mindfulness meditation, effectively decrease GAD symptoms, with effects comparable to cognitive behavioral therapy (CBT) in some studies. A 2020 RCT involving 226 adults with GAD found that 12 weeks of Kundalini yoga led to a 54% response rate in symptom reduction, though less robust than CBT's 71%, positioning yoga as a viable adjunct or alternative for those preferring non-verbal therapies. Recent narrative reviews from 2025 highlight that both yoga and mindfulness target transdiagnostic processes like attention control, showing preliminary equivalence to low-intensity interventions for mild GAD, supported by 20+ studies since 2013. Certain supplements may provide adjunctive relief for GAD symptoms, though evidence varies and professional consultation is advised due to potential interactions and risks. Omega-3 fatty acids, particularly at doses of 1-2 grams of EPA daily, have demonstrated anxiolytic effects, with one study reporting a 20% reduction in anxiety symptoms among participants. Passionflower extracts show positive results in RCTs for GAD and related anxiety, with three trials involving 278 participants indicating symptom improvement comparable to standard treatments, though mild side effects like dizziness may occur. Kava extracts have substantial evidence from 10 RCTs for reducing GAD symptoms, with 63% showing significant benefits at doses under 400 mg daily, but hepatotoxicity risks, including rare severe liver injury, warrant caution and monitoring per FDA advisories. Sleep hygiene protocols are essential for addressing the insomnia frequently comorbid with GAD, improving overall symptom management through better rest. Key strategies include maintaining a consistent sleep schedule by going to bed and waking at the same times daily, avoiding caffeine and heavy meals 4-6 hours before bedtime, and engaging in daytime exercise while steering clear of vigorous activity near bedtime. Creating an optimal sleep environment—quiet, dark, and cool—combined with relaxation techniques like progressive muscle relaxation, can interrupt anxious rumination and enhance sleep onset, as outlined in clinical guidelines for insomnia in anxiety disorders. These practices, when consistently applied, support reduced anxiety by fostering restorative sleep patterns.

Emerging and experimental treatments

Recent advancements in the treatment of generalized anxiety disorder (GAD) have focused on innovative digital, pharmacological, and neuromodulatory approaches, with several showing promise in clinical trials conducted between 2024 and 2025. These emerging therapies aim to address limitations in accessibility, efficacy, and durability of standard interventions, often targeting underlying neurobiological pathways more directly.^[84] Digital therapeutics represent a growing frontier, leveraging mobile technology to deliver cognitive behavioral therapy (CBT) principles in accessible formats. For instance, Anzeilax, a smartphone-based app providing CBT modules tailored for GAD, demonstrated significant efficacy in a 2025 randomized controlled trial (RCT) involving 96 adults. Participants using Anzeilax alongside treatment as usual (TAU) experienced a mean reduction of 3.58 points (28.8%) in GAD-7 scores over 10 weeks, compared to 1.27 points (10.3%) in the TAU-only group, with moderate effect sizes (Cohen's d = 0.60) and sustained benefits at 15-week follow-up. Similarly, text-message-delivered CBT (CBT-txt-A) for young adults aged 18-25 showed large effect sizes (Cohen's d = 0.83) in GAD-7 symptom reduction in a 2025 RCT with 102 participants, achieving remission in 25% of the treatment group versus 5.5% of controls, mediated by improvements in behavioral activation and reduced cognitive distortions. DaylightRx, the first FDA-cleared digital therapeutic for GAD in adults aged 22 and older, delivers app-based CBT as an adjunct to usual care, with clearance based on evidence of symptom improvement in 2024 trials. These tools enhance scalability, particularly for underserved populations, though long-term adherence remains a challenge.^[85]^[86] Psychedelic-assisted therapies have gained attention for their potential rapid and sustained effects. MM120, a pharmaceutical formulation of lysergide d-tartrate (LSD derivative), was evaluated in a phase 2b RCT published in 2025, involving 198 adults with moderate-to-severe GAD (baseline Hamilton Anxiety Rating Scale [HAM-A] scores ≥20). A single 100-μg dose led to a statistically significant 5.0-point greater reduction in HAM-A scores at week 4 compared to placebo (95% CI, -9.6 to -0.4), with a dose-dependent response and improvements in functional outcomes; the 200-μg dose showed a 6.0-point advantage (95% CI, -9.8 to -2.0). No serious adverse events were reported, supporting advancement to phase 3 trials expected to conclude in 2026. This approach, administered without concurrent psychotherapy, highlights psychedelics' potential to reset anxiety circuits via serotonin receptor agonism.^[87]^[88] Neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), are being refined for GAD targeting. A 2025 meta-analysis of rTMS studies confirmed its safety and efficacy, with significant reductions in anxiety symptoms regardless of comorbidities or stimulation parameters, yielding large effect sizes comparable to or exceeding those of established therapies. Early 2025 data from accelerated protocols targeting the right dorsomedial prefrontal cortex reported over 70% symptom improvement in some GAD patients, attributed to normalization of hyperactive fear networks. These non-invasive methods offer an alternative for treatment-resistant cases, with ongoing trials optimizing protocols for broader application.^[89]^[90] Prospects for gene therapy in GAD remain preclinical, centered on epigenetic targets identified in 2024-2025 research. Studies have linked DNA methylation alterations, such as elevated SLC6A4 promoter methylation, to GAD risk and symptom severity, suggesting potential for targeted epigenetic editing to restore serotonin transporter expression and mitigate anxiety vulnerability. Epigenome-wide association analyses from 2024 further implicated methylation sites in stress-response genes as mediators between environmental factors and GAD pathogenesis, paving the way for future therapies like CRISPR-based modifiers, though human trials are years away.^[91]^[92]

Comorbidities and prognosis

Common comorbid disorders

Generalized anxiety disorder (GAD) frequently co-occurs with other psychiatric conditions, with lifetime comorbidity rates exceeding 50% in many cases.^[93] Among these, major depressive disorder (MDD) is the most common, affecting approximately 60-67% of individuals with lifetime GAD.^[94] This high overlap is attributed to shared neurobiological pathways, including dysregulated serotonin and norepinephrine systems, as well as behavioral patterns like excessive worry and rumination that perpetuate both conditions.^[95] Other anxiety disorders also show substantial comorbidity with GAD, with 30-50% of individuals experiencing at least one additional anxiety disorder such as panic disorder or social anxiety disorder.^[96] For instance, social phobia co-occurs in about 23% of GAD cases, while panic disorder is present in up to 21.8% of comorbid presentations, often exacerbating overall symptom severity due to overlapping autonomic arousal features.^[97]^[98] Substance use disorders, particularly alcohol misuse, are elevated in GAD, with lifetime rates of 30-35% for comorbid alcohol abuse or dependence, compared to lower rates in the general population.^[99] This association is frequently linked to self-medication behaviors, where individuals use alcohol to alleviate persistent anxiety symptoms, though this often leads to worsened outcomes.^[100] Somatic conditions, including chronic pain syndromes and irritable bowel syndrome (IBS), frequently co-occur with GAD, reflecting the disorder's prominent physical manifestations and potential shared inflammatory or stress-related mechanisms. For example, IBS is strongly associated with GAD in community and clinical samples, contributing to heightened healthcare utilization.^[101]

Effects on prognosis and management

Comorbidities, particularly depression, significantly worsen the prognosis of generalized anxiety disorder (GAD) by increasing the risk of chronicity and impairing recovery. Individuals with comorbid major depressive disorder (MDD) and GAD exhibit slower symptom resolution and higher rates of persistent impairment compared to those with GAD alone.^[102] ^[103] In community-based longitudinal studies, comorbid MDD has been linked to substantially greater chronicity, with affected patients facing prolonged episodes and reduced functional recovery.^[104] Without significant comorbidities, remission rates for GAD are more favorable; for instance, approximately 41% of individuals with a lifetime history of GAD achieve full remission over a 5-year follow-up period in prospective community samples.^[95] Management of GAD in the context of comorbidities presents unique challenges, including the need for coordinated treatment strategies to mitigate risks associated with multiple interventions. Polypharmacy, common when addressing both GAD and comorbid conditions like depression, elevates the likelihood of drug-drug interactions, adverse events, and treatment nonadherence, particularly in complex cases requiring antidepressants alongside anxiolytics.^[105] ^[106] Integrated cognitive behavioral therapy (CBT) protocols designed for dual diagnoses offer a promising approach, targeting overlapping symptoms of worry, rumination, and avoidance to improve outcomes beyond standalone treatments.^[107] Recent data from 2025 highlight the enduring impact of the COVID-19 pandemic on GAD prognosis, especially in comorbid anxiety-depression clusters, where post-infection persistence exacerbates symptom severity and functional decline, including elevated rates of comorbid PTSD. Post-COVID cohorts show elevated rates of ongoing anxiety and depressive symptoms, with interdisciplinary care recommended to address intertwined neuropsychiatric sequelae and poorer long-term recovery.^[108] ^[109] Factors influencing recovery in comorbid GAD emphasize the value of timely intervention, which enhances remission likelihood and reduces chronic course progression. Early therapeutic engagement, such as prompt initiation of evidence-based psychotherapy or pharmacotherapy, is associated with improved remission rates, underscoring the importance of rapid access to integrated care.^[110]

Epidemiology

Global and regional prevalence

Generalized anxiety disorder (GAD) affects an estimated 3.7% of the global population over their lifetime based on epidemiological surveys. The 12-month prevalence stands at about 1.8%, with higher rates observed in high-income countries compared to low- and middle-income regions, where underreporting due to limited access to mental health services may obscure true figures. These estimates, derived from the World Mental Health Surveys, highlight GAD as a significant contributor to the broader burden of anxiety disorders, which impacted 359 million people globally in 2021 and an estimated 4.4% current prevalence (about 360 million people) as of 2025.^[111]^[13]^[112]^[13] In the United States, the 12-month prevalence of GAD among adults is 2.7%, with lifetime prevalence reaching 5.7%, according to data from the National Comorbidity Survey Replication. The COVID-19 pandemic led to a notable spike in anxiety symptoms, with global prevalence of anxiety disorders increasing by 25% in the first year, and U.S. reports indicating elevated rates of anxiety disorders and symptoms post-2020, particularly among young adults and women. Only about 43% of affected individuals receive treatment, underscoring gaps in care access.^[4]^[113]^[114] Across Europe and the United Kingdom, lifetime prevalence of GAD ranges from 1% to 7%, with a median 12-month prevalence of 1.7% based on systematic reviews of epidemiological studies. Rates are consistently higher among women, who experience GAD at nearly double the rate of men, and weekly diagnoses in England affect about 6% of the population. These figures reflect stable patterns post-2020, though urban areas show slightly elevated incidence.^[115]^[78]^[116] In low- and middle-income regions, GAD prevalence is often underestimated due to stigma and diagnostic barriers, but recent studies reveal higher urban rates. A 2025 population-based study in Tehran, Iran, found that 26% of urban adults met DSM-5 criteria for GAD symptoms, highlighting environmental and psychosocial stressors in such settings. This contrasts with global averages and points to the need for targeted surveillance in under-resourced areas.^[117]

Demographic patterns and risk factors

Generalized anxiety disorder (GAD) exhibits a pronounced gender disparity, with women approximately twice as likely to develop the disorder as men. Lifetime prevalence rates are estimated at 5.3% for women compared to 2.8% for men, yielding a female-to-male ratio of roughly 2:1. This difference may be influenced by hormonal fluctuations across the female lifespan, such as those during puberty, the menstrual cycle, pregnancy, postpartum periods, and perimenopause, which can exacerbate anxiety symptoms.^[118]^[119] The peak age of onset for GAD typically occurs in the 20s and 30s, with a median presentation around 30 years. Recent epidemiological data indicate a rising incidence among adolescents, particularly following the digital era's expansion of social media and screen time, which correlates with increased anxiety symptoms in this group. For instance, global incidence of anxiety disorders among those aged 10-24 years rose by 52% from 1990 to 2021, with accelerated increases post-2019 amid heightened digital engagement.^[7]^[83]^[120] Socioeconomic status significantly influences GAD risk, with lower socioeconomic positions associated with higher prevalence; odds ratios for low education or income levels range from 1.5 to 2.0 compared to higher-status groups. Ethnic disparities also emerge, particularly in the United States, where recent studies show elevated GAD rates among Hispanic populations, with anxiety symptom prevalence reaching 25.4%—higher than among non-Hispanic Whites.^[121]^[122] Additional risk factors include urban living environments, which elevate GAD risk due to heightened exposure to stressors like noise, crowding, and social disconnection, with urban residents showing up to 6% higher symptom severity than rural counterparts. Minority stress—chronic experiences of prejudice and discrimination—further compounds vulnerability, particularly among sexual minorities and racial/ethnic groups, increasing the likelihood of anxiety disorders through mechanisms like internalized stigma and social isolation.^[123]^[124]

History

Early descriptions and conceptualizations

The earliest descriptions of conditions resembling generalized anxiety disorder trace back to ancient Greek medicine, where Hippocrates (c. 460–370 BCE) characterized "melancholy" as a state involving persistent fear, sadness, and excessive worry, attributing it to an imbalance of black bile in the humoral system.^[125] He documented cases of chronic apprehension and somatic complaints, such as restlessness and insomnia, framing them as medical disorders rather than moral failings, as seen in his account of Nicanor, who suffered irrational fears during meals.^[125] In the 18th century, European physicians began conceptualizing anxiety-like states as "nervous exhaustion," linking them to depleted vital energies amid societal changes like urbanization.^[125] François Boissier de Sauvages (1706–1767) classified "panophobias" in his nosology, describing generalized anxiety features such as constant worry, social withdrawal, and somatic symptoms like palpitations and breathlessness, often triggered by perceived threats or vapors.^[125] This era marked a shift toward viewing chronic worry as a nervous disorder rather than episodic fear. The 19th century saw American neurologist George Miller Beard introduce "neurasthenia" in 1869 as a prototype for chronic anxiety, portraying it as a fatigue of the nervous system caused by modern life's demands, including telegraphy and rapid travel.^[125] Beard's seminal work described symptoms like persistent apprehension, irritability, headaches, and digestive issues, affecting primarily educated urbanites and framing it as an "American nervousness" epidemic.^[126] He advocated rest cures, influencing treatments for what he saw as a debilitating, non-psychotic condition.^[127] Cultural expressions of anxiety varied globally, often manifesting somatically; for instance, in Punjabi traditions, "sinking heart" (dhak dhadkan) described distress as heart-centered worry and palpitation, reflecting holistic views of emotional and physical imbalance.^[128] Similar idioms appeared in other non-Western contexts, emphasizing relational or spiritual disharmony over isolated psychological states.^[129] By the early 1900s, Sigmund Freud shifted conceptualizations from somatic to psychological origins, distinguishing "anxiety neurosis" as repressed libido transforming into free-floating worry, separate from neurasthenia.^[125] In works like Studies on Hysteria (1895), Freud posited anxiety as a signal of unconscious conflict, laying groundwork for psychodynamic understandings.^[130]

Development of modern diagnostic frameworks

The development of modern diagnostic frameworks for generalized anxiety disorder (GAD) began in the late 20th century with efforts to distinguish it from other anxiety conditions. In the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), published in 1980 by the American Psychiatric Association, GAD was established as a standalone diagnosis for the first time, separate from panic disorder and other anxiety states that had previously subsumed it under broader categories like anxiety neurosis.^[131] This separation emphasized chronic, diffuse anxiety persisting for at least one month, without requiring a specific focus on worry, marking a shift from earlier conceptualizations where GAD symptoms were often viewed as residual or secondary to other neuroses.^[132] Subsequent revisions refined these criteria to enhance specificity and clinical utility. The DSM-IV, released in 1994, tightened the diagnostic threshold by centering uncontrollable worry as the core symptom, extending the required duration to six months, and mandating at least three associated symptoms such as restlessness or muscle tension, which reduced overlap with adjustment disorders and improved reliability. Building on this, the DSM-5 in 2013 further emphasized the uncontrollability of worry as a explicit criterion, removed the hierarchical exclusion rule that had previously barred GAD diagnosis in the presence of mood disorders, and incorporated greater flexibility for comorbid conditions, reflecting empirical evidence that GAD often co-occurs independently.^[3] These changes aimed to better capture the disorder's pervasive nature while aligning with longitudinal studies showing its distinct course.^[93] Parallel advancements occurred in the International Classification of Diseases (ICD) system by the World Health Organization. The ICD-10, introduced in 1992, defined GAD (F41.1) through prominent tension, worry, and physiological arousal lasting at least several months, focusing on autonomic symptoms like irritability and sleep disturbance without a strong emphasis on cognitive uncontrollability.^[133] In contrast, the ICD-11, effective from 2019, broadened the framework (6B00) to include avoidance behaviors triggered by anxiety-provoking situations, alongside persistent excessive worry across multiple life domains for several months, and required significant distress or impairment not attributable to other disorders, promoting a more dimensional and inclusive approach aligned with global clinical data.^[134] As of 2025, the American Psychiatric Association has unveiled early plans for the next iteration of the DSM, aiming for publication within approximately four years and envisioning it as a "living document" to incorporate scientific advances. These plans include exploratory work by subcommittees on biomarkers—such as through wearable devices—and developing dimensional models to address the spectrum of anxiety disorders, with efforts to harmonize further with the ICD-11.^[135]

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Jun 17, 2021 · SSRIs and SNRIs (referred to collectively as SRIs hereafter) are the treatment of choice for pharmacologic management of generalized anxiety ...Generalized Anxiety Disorder · Panic Disorder · Social Anxiety Disorder
[69]
Pharmacological Treatment of Generalised Anxiety Disorder
A range of effective treatments for GAD are available, particularly duloxetine, escitalopram, pregabalin, quetiapine, and venlafaxine.
[70]
A Systematic Review and Network Meta-analysis of Double-Blind ...
Nov 10, 2020 · Duloxetine, escitalopram, venlafaxine, paroxetine, and quetiapine showed better remission but were poorly tolerated.Abstract · Introduction · Materials and Methods · Discussion
[71]
Benzodiazepines: Uses, Dangers, and Clinical Considerations - PMC
Nov 10, 2021 · Regular use of BZDs has been shown to cause severe, harmful psychological and physical dependence, leading to withdrawal symptoms similar to ...
[72]
Risks Associated with Long-Term Benzodiazepine Use - AAFP
Aug 15, 2013 · Benzodiazepines increase the risk of addiction, withdrawal, cognitive decline, motor vehicle crashes, and hip fracture.
[73]
Effectiveness of Buspirone in Alleviating Anxiety Symptoms in ... - NIH
Subgroup analyses revealed that augmentation of SSRI or SNRI treatment with buspirone improved depression and anxiety symptoms in patients with severe ...
[74]
Generalized Anxiety Disorder and Panic Disorder in Adults - AAFP
The symptoms of GAD and PD can suggest medical diagnoses, including hyperthyroidism, arrhythmias, asthma, chronic obstructive pulmonary disease, certain ...Abstract · Typical Presentation and... · Diagnosis, Comorbidity, and... · Treatment
[75]
Could This Novel Therapy Calm Anxiety for Millions of Americans?
Oct 7, 2025 · The drug significantly alleviated symptoms, reducing them by five to six points on the anxiety scale in addition to the effects of placebo.
[76]
Efficacy of a Smartphone-Based Digital Therapeutic (Anzeilax) in ...
Oct 14, 2025 · Objective: This study aimed to evaluate the efficacy of Anzeilax in reducing anxiety symptoms in individuals with GAD. Methods: A 10-week, ...
[77]
FDA Clears Digital Therapeutic for Generalized Anxiety Disorder
Sep 24, 2024 · DaylightRx is intended to provide cognitive behavioral therapy (CBT) for patients aged 22 years and older with GAD. The app-based intervention ...
[78]
Single Treatment With MM120 (Lysergide) in Generalized Anxiety ...
Sep 4, 2025 · This trial was the first to assess the dose-dependent efficacy of MM120 (LSD) without a co-occurring psychotherapeutic intervention. The 100-µg ...
[79]
Journal of the American Medical Association (JAMA) Publishes ...
Sep 4, 2025 · ... Trial Assessing the Dose-Dependent Efficacy of MM120 (Lysergide D-Tartrate, LSD) in Generalized Anxiety Disorder (GAD). Sep 04, 2025 11:05 am ...
[80]
Effectiveness and safety of repetitive transcranial magnetic ...
The rTMS could be an effective and safe treatment for patients with GAD. However, these findings should be interpreted with caution due to ...Missing: efficacy | Show results with:efficacy
[81]
Does TMS Work for Anxiety? (What the Research Says) - Cognitive FX
Aug 11, 2025 · Preliminary studies have shown encouraging results. One study, for example, reported a reduction of over 70% in anxiety symptoms among patients ...
[82]
The clinical use of epigenetics in psychiatry: a narrative review of ...
Elevated SLC6A4 methylation is also associated with generalized anxiety disorder (GAD) and panic disorder, correlates with increased anxiety traits, social ...
[83]
Epigenetic markers of disease risk and psychotherapy response in ...
Apr 25, 2025 · The present epigenome-wide case-control association study in the final sample of 378 anxiety disorder patients vs. 295 healthy controls revealed ...
[84]
Comorbidity of Generalized Anxiety Disorder and Substance Use ...
Individuals with GAD-SUD showed higher psychiatric comorbidity rates than those with GAD-NSUD. Treatment seeking rates for GAD are equally low in GAD-SUD and ...
[85]
Diagnostic Overlap of Generalized Anxiety Disorder and Major ... - NIH
Nov 26, 2012 · Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are highly comorbid. A possible explanation is that they share four ...
[86]
Predictors of remission from Generalized Anxiety Disorder and ... - NIH
These two conditions often co-occur;3 Brown et al4 estimated the concurrent and lifetime comorbidity of MDD in GAD at 26% and 64%, respectively, and the ...
[87]
A trans-diagnostic review of anxiety disorder comorbidity and the ...
Jun 28, 2016 · Our initial analysis of lifetime comorbidity survey data showed that at least 60% of participants with one anxiety disorder had one or more ...
[88]
Psychiatric comorbidity in patients with generalized anxiety disorder
The most prevalent comorbid diagnoses were social phobia (25 [23%] of the patients) and simple phobia (23 [21%] of the patients). Forty-six (42%) of the ...
[89]
Strategies for Assessing and Treating Comorbid Panic and ...
An international study of lifetime comorbidities found a high rate (21.8%) of panic disorder and GAD; most people (55.8%) reported that the symptoms of GAD and ...
[90]
Anxiety Disorders With Comorbid Substance Abuse | Psychiatric Times
Sep 7, 2011 · For patients with generalized anxiety disorder (GAD), the lifetime prevalence of comorbid alcohol abuse and dependence is 30% to 35%, and the ...
[91]
Anxiety Disorders with Comorbid Substance Use Disorders - NIH
A recent epidemiologic study of 5,877 adults found that GAD was the anxiety disorder most often associated with using alcohol or drugs to self-medicate symptoms ...Specific Disorders · Generalized Anxiety Disorder · Posttraumatic Stress...
[92]
Systematic review of the comorbidity of irritable bowel syndrome ...
The nongastrointestinal nonpsychiatric disorders with the best-documented association are fibromyalgia (median of 49% have IBS), chronic fatigue syndrome (51%), ...
[93]
Irritable bowel syndrome is strongly associated with ... - PubMed
Sep 15, 2009 · The current prevalence of IBS was 5.4% and the 12-month prevalence of GAD was 4%. GAD was five times more common among IBS respondents than non- ...
[94]
Comorbid generalized anxiety disorder and its association with ...
Jan 18, 2017 · A recent empirical study showed that more than 80% of patients with MDD or bipolar disorder have at least one current comorbid mental disorder.
[95]
The Critical Relationship Between Anxiety and Depression
May 1, 2020 · Across psychiatric disorders, the presence of significant anxiety symptoms generally predicts worse outcomes, and this has been well ...
[96]
The Comorbidity of Major Depression and Anxiety Disorders - NIH
The prevalence of depressive and anxiety disorders in primary care settings is high. Between 10% and 20% of adults in any given 12-month period will visit their ...
[97]
Polypharmacy - StatPearls - NCBI Bookshelf
Polypharmacy, defined as the regular use of 5 or more medications at the same time, is common in older adults and at-risk younger individuals.
[98]
Determinants and consequences of polypharmacy in patients ... - NIH
Polypharmacy is an independent risk factor for chronic depression. Motivational problems, anxiety, and pain may increase prescribing behavior in patients with ...
[99]
Treating comorbid anxiety and depression: Psychosocial and ... - NIH
The treatment of comorbid anxiety and depression necessitates specific psychopharmacological adjustments as compared to treating either condition alone.
[100]
Long COVID in people with mental health disorders: a scoping review
Jul 1, 2025 · Evidence on the impact of Long COVID on pre-existing mental health conditions was inconsistent. Most findings focused on the course of mental ...
[101]
Depression and Anxiety in Long COVID - Yale Medicine
Jun 10, 2024 · Depression and anxiety commonly occur in people with Long COVID. Research is beginning to find some possible explanations.Missing: comorbid | Show results with:comorbid
[102]
Personality Disorders and Time to Remission in Generalized Anxiety ...
Results The presence of a PersD predicted a 30% lower likelihood of generalized anxiety disorder remission, a 39% lower likelihood of social phobia remission, ...
[103]
Prevention and early intervention in youth mental health: is it time for ...
Mar 24, 2020 · Results suggested that indicated interventions have positive effects not only in reducing the presenting problem but also in improving other ...Indicated Prevention... · Secondary Prevention In... · Tertiary Prevention In Youth...
[104]
Prevalence and correlates of generalized anxiety disorder and ...
Jun 15, 2025 · The weight 12-month prevalence of generalized anxiety disorder is 3.5 %. The weight 12-month prevalence of subthreshold anxiety symptoms (SAS) is 10.0 %.
[105]
Epidemiology of anxiety disorders: global burden and ...
May 26, 2023 · An estimated 4.05% of the global population has an anxiety disorder, translating to 301 million people. The number of persons affected has increased by more ...Prevalence · Age Of Onset · Discussion
[106]
COVID-19 pandemic triggers 25% increase in prevalence of anxiety ...
Mar 2, 2022 · In the first year of the COVID-19 pandemic, global prevalence of anxiety and depression increased by a massive 25%, according to a scientific brief released by ...
[107]
Prevalence | Background information | Generalized anxiety disorder
Generalized anxiety disorder (GAD) is more common in high income countries, and has a lifetime prevalence of 1–7% in Europe.
[108]
Anxiety statistics UK 2025 - Priory Group
In any given week in England, 6 in 100 people are diagnosed with Generalised Anxiety Disorder. · In 2022/23, an average of 37.1% of women and 29.9% of men ...
[109]
Exploring generalized anxiety disorder symptoms: key insights from ...
Mar 19, 2025 · This study investigates the socio-demographic, environmental, and psychosocial risk factors for GAD symptoms in an urban Iranian population
[110]
Gender differences in Generalized Anxiety Disorder - PubMed Central
Feb 24, 2016 · The lifetime prevalence rates of DSM-IV GAD were 2.8% for men and 5.3% for women, whereas the 12-month rates of GAD were 1.2% for men, and 2.7% ...Prevalence And... · Comorbidity · Treatment Seeking
[111]
Anxiety Disorders Among Women: A Female Lifespan Approach
Lifetime prevalence of GAD is greater among women (about 6%) than among men (about 3%) (34). Perinatally, GAD prevalence ranged from 0% to 10% in a systematic ...The Female Lifespan · Panic Disorder · Biopsychosocial...
[112]
Rising global burden of anxiety disorders among adolescents and ...
Nov 26, 2024 · ... disability burden of anxiety disorders across various regions. These studies reveal significant global disparities, often reflecting ...
[113]
Socio-economic position and mental disorders in a working-age ...
Sep 27, 2011 · Self-employment and low educational level were associated with anxiety disorder (respective ORs = 1.52 and 1.55, CIs = 1.01–2.30 and 1.16–2.07).<|separator|>
[114]
The burden of anxiety among a nationally representative US adult ...
Sep 1, 2023 · The total prevalence of anxiety symptoms in the US adult population is 44.0%. •. 11.5% of the population experiences mild to severe anxiety ...
[115]
Urban–Rural Differences in Mental and Physical Health among ...
Nov 24, 2022 · Residing in an urban area was associated with a relative change of 6% higher generalized anxiety disorder symptom severity, 5% lower total ...
[116]
Anxiety and Related Disorders and Concealment in Sexual Minority ...
This social stigma and minority stress places sexual minorities at risk for anxiety and related disorders. Given that three fourths of anxiety disorder onset ...
[117]
A history of anxiety: from Hippocrates to DSM - PMC - NIH
Panic attacks and generalized anxiety disorder may be recognized in the “panophobias” in the nosology published by Boissier de Sauvages in the 18th century.
[118]
Neurasthenia - an overview | ScienceDirect Topics
In 1869, George Beard (New York) invented the term 'neurasthenia' to encompass many non-psychotic or psychosomatic disorders attributed to exhaustion of nerves.
[119]
'Americanitis': The Disease of Living Too Fast - The Atlantic
Mar 11, 2016 · “Neurasthenia did not simply denote the presence of sickness. Beard argued it indicated the presence of an active mind, a competitive character, ...
[120]
Sinking heart: A Punjabi communication of distress - ScienceDirect
The paper describes a syndrome of heart distress referred to as 'sinking heart' by Punjabis living in Bedford, and it discusses how far this condition ...
[121]
Cross-Cultural Aspects of Anxiety Disorders - PMC - NIH
A person's cultural background influences the experience and expression of emotions. In reviewing the recent literature on cross-cultural aspects of anxiety ...
[122]
What did Freud say about Anxiety? - Freud Museum London
First phase: the toxic theory. “Anxiety arises from a transformation of the accumulated tension.” ; Second phase: anxiety as a result of repression. “Anxiety ...
[123]
Generalized Anxiety Disorder | Focus - Psychiatry Online
In the ECA study, for example, 40% of those with GAD had the diagnosis for more than 5 years (35). ... Generalized anxiety disorder: diagnosis and treatment.
[124]
The history of generalized anxiety disorder as a diagnostic category
From the 19th century into the 20th century, the terms used to diagnose generalized anxiety included “pantophobia” and “anxiety neurosis.”
[125]
Comparison of the Epidemiology of DSM-5 Generalized Anxiety ...
Mar 15, 2017 · In the current WMH surveys, lifetime prevalence is 37% higher and 12-month prevalence is 50% higher for DSM-5 than DSM-IV GAD (Ruscio AM, ...
[126]
Diagnostic criteria for anxiety disorders set out in DSM-IV and ICD ...
Obsessions as defined by (1), (2), (3) and (4): recurrent and persistent thoughts, impulses or images that are experienced, at some time during the disturbance ...
[127]
[PDF] Anxiety Disorders: ICD-10 / ICD-11 & DSM – V
Different sorts separated as a) uneasiness mental issues, b) insane despondency, c) insane depression transformation type, d) insane despondency dissociative ...
[128]
APA Unveils Early Plans for the Next DSM - Medscape
Jun 2, 2025 · The last fully new DSM was DSM-5, which was published in 2013. The latest update, the Text Revision version (DSM-5-TR), was released in 2022.
[129]
Digital phenotyping of generalized anxiety disorder: using artificial ...
Aug 17, 2022 · The development of digital phenotypes of GAD may enable new scalable, timely, and inexpensive assessments of GAD symptoms. Method. The current ...
[130]
Trauma-Informed Therapy - StatPearls - NCBI Bookshelf
Aug 16, 2024 · Trauma-informed approaches such as dialectical behavior therapy (DBT), mentalization-based therapy (MBT), and eye movement desensitization and ...
[131]
Understanding the Relationship between Anxiety and Trauma
Feb 18, 2025 · Trauma-informed care and individualized therapeutic approaches can enhance outcomes for clients experiencing anxiety from trauma.