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GF Biochemicals

GF Biochemicals is a biochemical company founded in 2008 by , a former professional footballer who played for clubs including and , and Pasquale Granata, focused on developing and producing sustainable, plant-based chemicals from to replace harmful in everyday products. Headquartered in , , with operations in the , , , and , the company specializes in levulinate technologies and is the world's first to produce derivatives at commercial scale directly from renewable feedstocks. Its proprietary RE:CHEMISTRY platform, launched after over a decade of , enables a one-step process for creating high-performance, bio-based ingredients that are safer and more environmentally friendly for applications in personal care (such as shampoos), home care (like detergents), and industrial sectors. In 2016, the company acquired Segetis, enhancing its capabilities in derivatives. GF Biochemicals holds more than 200 active patents, underscoring its innovation in , and has built a global to support scalable production of these drop-in replacements for fossil-based chemicals. The company's mission emphasizes , with products designed to reduce toxicity and carbon footprints while maintaining efficacy, aligning with broader industry shifts toward bio-based solutions. In 2025 developments, GF Biochemicals accelerated growth through strategic leadership hires to expand its sustainable chemistry portfolio and entered a sole distribution agreement with to bring its solutions to CASE and markets. It also earned an EcoVadis Silver rating in 2025 for its environmental and governance standards and won the 2025 ICIS Innovation Award for Best Product Innovation from an , highlighting its commitment to responsible business practices.

History

Founding and early development

GF Biochemicals was co-founded in 2013 by , a former professional footballer who played for clubs including and , and Italian entrepreneur Pasquale Granata. The company name, GF, derives from the initials of the founders. Their collaboration began during Flamini's time in Italy, where he met Granata, an individual with interests in the , leading to the establishment of the firm focused on advancing sustainable chemical solutions. From its , GF Biochemicals aimed to develop biobased chemicals as alternatives to petroleum-derived products, drawing from close work with a group of biobased chemical experts. The founders' vision centered on creating plant-based ingredients that could replace harmful in consumer goods, addressing environmental concerns associated with traditional chemical production. This initial emphasis laid the groundwork for the company's commitment to innovations. A key aspect of the early development involved a seven-year research partnership with the , during which the company refined technologies for converting into valuable chemicals, including breakthroughs in the production of as a versatile platform molecule. This collaboration enabled significant advancements in sustainable conversion processes, positioning GF Biochemicals at the forefront of biobased innovation. The partnership underscored the company's research-driven origins, fostering expertise in utilization. Central to GF Biochemicals' early mission was the goal to "end chemical " by developing safe, plant-based alternatives for everyday products such as shampoos and food additives, thereby reducing reliance on polluting and promoting a shift toward principles. This objective guided the company's foundational efforts, emphasizing environmental and practical applications of biobased materials.

Key milestones and acquisitions

In 2015, GF Biochemicals achieved a significant milestone by commencing commercial-scale production of at its facility in , , transitioning the company from research and development to market-ready operations as the first firm to produce this biomass-derived chemical at such a scale. The company's expansion accelerated in 2016 with the acquisition of Segetis, a U.S.-based producer of levulinic acid derivatives, which included its manufacturing plant in and extensive portfolio; this move established GF Biochemicals' direct presence in the American market through GFBiochemicals Americas and broadened its capabilities in derivative synthesis. In February 2020, GF Biochemicals formed a with Towell Engineering Group called NXTLEVVEL Biochem, headquartered in , the , to produce and market bio-solvents and bio-plasticizers based on derivatives, leveraging the partners' expertise for global expansion. In May 2022, GF Biochemicals secured a €15 million Series A funding round, led by the firm Sofinnova Partners with participation from Sparta Group, to scale operations, enhance , and forge strategic partnerships in sustainable chemistry. By 2025, the company had amassed over 200 active patents focused on conversion technologies and derivative applications, underscoring its leadership in bio-based innovation. That same year, GF Biochemicals bolstered its executive team with key hires—including a & Director to optimize supplier networks and logistics, a Plant Project Director to oversee scaling from pilot to full production, and a Manager to drive adoption of its RE:CHEMISTRY portfolio in sectors like plastics and packaging—aimed at supporting rapid global growth amid increasing demand for sustainable solutions.

Technology and products

Levulinic acid production process

GF Biochemicals utilizes a proprietary adaptation of the Biofine process, a two-stage acid-catalyzed method, to produce directly from renewable feedstocks. This technology converts lignocellulosic agro-waste, such as and wood chips, into through the breakdown of its components into C5 () and C6 () sugar intermediates, with pentoses yielding as a co-product and hexoses proceeding to formation. The core reaction pathway for sugars involves under high and in the presence of a dilute catalyst, typically , to form the key intermediate 5-hydroxymethylfurfural (HMF). HMF then rehydrates in a subsequent milder stage to produce (CH₃COCH₂CH₂COOH) and as a by-product, with the overall process operating in an aqueous environment without the need for organic solvents. This yields up to 70-80 mol% from sugars, significantly higher than many alternative conversion routes due to optimized conditions that minimize side reactions like formation. Compared to traditional levulinic acid production methods, which often rely on routes or less efficient processes, GF Biochemicals' approach offers key advantages, including a claimed of over 50% through efficient by-product utilization (e.g., and for ) and streamlined purification. The water-based system avoids corrosive organic solvents, enhances environmental compatibility, and supports scalability to commercial volumes, as demonstrated by the company's first industrial-scale facility in Caserta, , which began operations in 2015 with a of 10,000 metric tons per year. The process achieves pharmaceutical-grade purity exceeding 99 wt%, enabled by a patent-pending purification involving techniques like to remove impurities and co-products. Initial production at the Caserta plant ramped up from approximately 1,200 metric tons in 2015 to targeted levels supporting full by 2016, marking a pivotal advancement in sustainable platform chemical manufacturing.

Derivatives and applications

GF Biochemicals develops a range of levulinic acid-based derivatives under its RE:CHEMISTRY brand, focusing on high-performance, plant-based alternatives to ingredients. The portfolio includes Solve100, a bio-based ethyl levulinate designed for use in coatings and formulations requiring low and high solvency power. Move200, consisting of butyl levulinate, serves as a in applications, offering compatibility with various resins while enhancing flexibility. Clean300, a levulinate ketal, functions as an agent in , providing broad-spectrum efficacy against microbes in and toiletries. New320, another levulinate ketal variant (ethyl PG-acetal levulinate), acts as a non-toxic in skincare formulations, replacing volatile silicones like cyclopentasiloxane. These derivatives are primarily produced through chemical modifications of , such as esterification to form alkyl levulinates like ethyl and butyl levulinate, which are utilized in fuel additives and plasticizers, respectively. Other reactions yield salts like sodium levulinate, employed as preservatives, and ketal formations for enhanced stability in solvents. These processes enable the creation of multifunctional compounds that maintain the core reactivity of while tailoring properties for specific end-uses. The applications of these levulinic acid derivatives span multiple industries, providing sustainable options for diverse needs. In personal care, Clean300 and New320 deliver antimicrobial protection and emolliency in , reducing reliance on synthetic preservatives. For polymers, Move200 acts as a drop-in , serving as a phthalate alternative to improve material durability without compromising performance. In pharmaceuticals, intermediates support synthesis of active compounds and excipients. Food applications incorporate sodium levulinate as a natural preservative to extend in clean-label products. Biofuels benefit from ethyl levulinate as an oxygenate additive in blends, enhancing combustion efficiency. GF Biochemicals' derivatives reach markets in 193 countries through a network of distribution partners, emphasizing replacements for such as in production and in resins. This global reach underscores their role in scaling bio-based solutions for high-volume industrial applications.

Operations

Manufacturing facilities

GF Biochemicals operates its primary manufacturing facility in , , located in the southern region near . The plant, which was leased in 2009 for initial demonstration purposes in partnership with the , commenced commercial-scale production of bio-based in July 2015, becoming the world's largest operational site for this product at the time. Following the 2016 acquisition of Segetis' assets and portfolio, the facility expanded to integrate advanced derivative production capabilities, enhancing its role in . The plant concentrates on the synthesis of from feedstocks and the subsequent processing of its derivatives for various industrial applications. Its annual production capacity stands at 10,000 metric tons for , supporting scalable output for key bio-based chemicals. The infrastructure at the Caserta site features integrated processing units capable of handling cellulosic and other renewable feedstocks, alongside specialized purification systems designed to achieve high-purity outputs suitable for commercial markets. As an EU-based chemical producer, the facility adheres to stringent regulatory standards, including REACH for chemical registration, evaluation, authorization, and restriction, ensuring environmental and safety compliance throughout operations.

Global presence and partnerships

GF Biochemicals maintains its headquarters and R&D/application laboratories in , , supporting core innovation and administrative functions. The company also operates a facility alongside marketing and sales offices in , , to drive European market development and commercialization efforts. Additional representative offices are located in , , facilitating North American operations established following the 2016 acquisition of Segetis, a key producer of derivatives. To expand its commercial footprint, GF Biochemicals has formed strategic distribution agreements across key regions. In March 2025, the company entered an exclusive partnership with , the global chemicals distributor, to supply three sustainable levulinate esters for the European coatings, adhesives, sealants, and elastomers (CASE) markets, enhancing access to safer bio-based solvents. Earlier, in 2022, its NXTLEVVEL Biochem—formed in 2020 with Oman's Towell Group—signed a distribution agreement with BTC Europe (a division) to deliver biobased and biodegradable levulinate solvents throughout , targeting chemical applications in industries like coatings and cleaners. These alliances, bolstered by a €15 million Series A in 2022, have supported GF Biochemicals' growth in and , particularly in personal care and polymers sectors through manufacturing and sales in and in , . Beyond commercial partnerships, GF Biochemicals engages in strategic alliances with academic and industry organizations to advance sustainable chemistry. The company maintains ongoing collaborations with the and the , which have contributed to the development and validation of its production technologies. It is also a member of the World Alliance for Efficient Solutions, an initiative by the Solar Impulse Foundation that promotes innovative, impactful technologies for environmental challenges.

Sustainability and impact

Environmental initiatives

GF Biochemicals utilizes renewable agro-waste feedstocks, such as plant-based , to produce , thereby reducing reliance on fossil fuels. This approach enables a significant decrease in CO2 emissions, achieving reductions of up to 100% compared to traditional production methods. The company's RE:CHEMISTRY platform focuses on replacing harmful ingredients in consumer products with bio-based alternatives derived from . These products have reduced toxicity profiles and enhanced biodegradability, supporting safer formulations for industries including personal care, coatings, and cleaning. In May 2025, GF Biochemicals earned an EcoVadis Silver rating, which assesses across the , including environmental performance, ethical practices, and labor standards. This underscores the company's commitment to transparent and responsible operations. GF Biochemicals holds over 200 patents that advance principles, particularly through waste-to-value conversion processes that transform agro-waste into high-value chemicals while minimizing resource consumption. These innovations contribute to broader goals by promoting resource efficiency and reducing environmental footprints.

Awards and recognition

GF Biochemicals received the John Sime Award for Most Innovative New Technology in 2015 from Bioplastics Magazine at the European Forum for Industrial Biotechnology and the Bioeconomy (EFIB), recognizing its pioneering commercialization of derived from as a sustainable alternative to petroleum-based chemicals. In recognition of its 100% renewable production processes, the company became a member of the Foundation's World Alliance for Efficient Solutions as of 2024, with its RE:CHEMISTRY line of bio-based solvents earning the Efficient Solution label for bridging environmental protection and economic viability. The company's founders' story garnered significant media attention in 2016, including a feature highlighting co-founder Mathieu Flamini's vision for sustainable biochemistry through levulinic acid innovation. GF Biochemicals has also been included in key reports for its role in advancing bio-based platform chemicals, such as , as a cornerstone for sustainable polymer and solvent production. In 2025, GF Biochemicals achieved an EcoVadis Silver rating, benchmarking its strong performance in practices among global supply chains. That same year, the company won the ICIS Innovation Award for Best from an for its RE:CHEMISTRY platform. It also received industry praise for its expansions in bio-materials, exemplified by an exclusive with to distribute levulinate esters across CASE markets, enhancing access to safer, bio-based solutions.

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