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Hypophyseal portal system

The hypophyseal portal system, also known as the hypothalamo-hypophyseal portal system, is a specialized vascular network that directly connects the hypothalamus to the anterior pituitary gland, enabling the efficient transport of hypothalamic releasing and inhibiting hormones to regulate pituitary hormone secretion without initial dilution in the systemic circulation.^[1] This system comprises two capillary plexuses linked by portal veins: a primary plexus in the median eminence of the hypothalamus, where hormones such as thyrotropin-releasing hormone (TRH), gonadotropin-releasing hormone (GnRH), and corticotropin-releasing hormone (CRH) are released from hypothalamic neurons, and a secondary plexus in the pars distalis of the anterior pituitary, where these regulatory factors stimulate or inhibit the production of anterior pituitary hormones including thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), and prolactin.^[2] First described in 1930 by Popa and Fielding as a portal circulation facilitating blood flow from the hypothalamus to the pituitary, the system was recognized for its role in neuroendocrine integration, building on earlier anatomical observations like those by Thomas Willis in 1664 regarding the arterial supply to the region.^[1] Anatomically, the hypophyseal portal system is supplied primarily by the superior hypophyseal artery, a branch of the internal carotid artery, which forms the initial capillary bed in the hypothalamus's infundibulum and median eminence.^[3] Blood from this plexus drains through long portal veins that descend along the pituitary stalk to the anterior pituitary, while shorter portal vessels interconnect the posterior pituitary (neurohypophysis) with the anterior lobe, contributing approximately 30% of the anterior pituitary's blood supply and allowing some bidirectional exchange.^[1] The system's design as a true portal circulation—featuring veins between two capillary beds—ensures high concentrations of hypothalamic factors reach pituitary target cells, supporting rapid and precise endocrine responses to physiological needs such as stress, reproduction, growth, and metabolism.^[4] Functionally, the hypophyseal portal system is integral to the hypothalamic-pituitary axis, coordinating the release of hormones that influence distant target organs throughout the body; for instance, hypothalamic CRH delivered via the portal system prompts anterior pituitary ACTH secretion, which in turn stimulates adrenal cortisol production.^[1] Disruptions to this system, such as those caused by pituitary stalk lesions, can lead to deficiencies in multiple hormone axes, underscoring its clinical significance in endocrinology.^[2] In the posterior pituitary, while not directly part of the portal system, axonal projections from hypothalamic magnocellular neurons (in the paraventricular and supraoptic nuclei) terminate here, releasing vasopressin and oxytocin directly into systemic veins, complementing the anterior regulation.^[3] Overall, this portal arrangement exemplifies the hypothalamus's role as a master regulator of endocrine homeostasis, comprising only about 0.3% of brain volume yet exerting profound influence on pituitary function and whole-body physiology.^[5]

Anatomy

Gross anatomy

The hypophyseal portal system constitutes a unique vascular linkage between the hypothalamus and the anterior pituitary gland (adenohypophysis), situated within the sella turcica of the sphenoid bone. This system enables the direct conveyance of hypothalamic releasing and inhibiting hormones to the pituitary without admixture into the general circulation, thereby ensuring precise neuroendocrine regulation. Spatially, it encompasses the median eminence, infundibulum (pituitary stalk), and anterior lobe, with vessels traversing the diaphragma sellae to integrate hypothalamic and pituitary functions in a compact anatomical arrangement.^[1] The primary capillary plexus arises in the median eminence of the hypothalamus, a ventral extension of the third ventricle floor, where fenestrated capillaries—characterized by porous endothelial fenestrae—facilitate the diffusion of hormones from nearby hypothalamic neurons into the bloodstream. These capillaries form an intricate network of loops and pillars in the external and internal zones of the median eminence, optimizing hormone release proximal to the portal circulation. Arterial supply to this plexus derives primarily from the superior hypophyseal arteries, which branch from the supraclinoid segment of the internal carotid arteries or the posterior communicating arteries, forming an anastomotic circle around the pituitary stalk. The inferior hypophyseal arteries, arising from the meningohypophyseal trunk of the internal carotid, supply the posterior pituitary and contribute to short connections within the system.^[1]^[6] Blood from the primary plexus collects into venules that coalesce into long and short portal veins, which course inferiorly along the infundibulum to deliver enriched blood to the secondary capillary plexus embedded within the anterior pituitary parenchyma. Long portal veins, comprising the majority of the drainage, extend directly from the median eminence to the pars distalis of the adenohypophysis, while short portal veins link the posterior pituitary (pars nervosa) to the anterior lobe, accounting for approximately 30% of the latter's blood supply and enabling limited bidirectional exchange. This dual venous architecture underscores the system's efficiency in targeting the anterior pituitary while minimizing dilution.^[1] The hypophyseal portal system is organized into a primary capillary plexus in the median eminence connected by long portal veins directly to the secondary plexus in the anterior pituitary (pars distalis), with short portal veins linking the posterior pituitary to the anterior lobe. Post-capillary venules from the secondary plexus drain via adenohypophyseal and neurohypophyseal veins into the cavernous sinus, with ultimate outflow to the internal jugular veins, thereby integrating the pituitary circulation with dural venous pathways. These features highlight the system's zonal organization and its embedding within the hypophyseal fossa.^[1]^[6]

Microscopic features

The hypophyseal portal system features fenestrated endothelium in both the primary capillary plexus of the median eminence and the secondary plexus within the adenohypophysis, characterized by transcellular pores measuring 50-100 nm in diameter that enable the passage of peptide hormones while restricting larger molecules.^[7]^[8] These fenestrations, often covered by thin diaphragms composed of plasmalemmal proteins like PV-1, enhance vascular permeability essential for neuroendocrine signaling.00523-0) Unlike typical brain capillaries protected by the blood-brain barrier, the endothelial cells in the hypothalamic capillaries of the portal system lack tight junctions, allowing bidirectional diffusion of regulatory factors between the neural and vascular compartments.^[9] This specialized architecture contrasts sharply with the sealed junctions in non-circumventricular regions, facilitating rapid hormone exchange without compromising overall barrier integrity elsewhere in the hypothalamus. Supporting these vessels are pericytes, which envelop the endothelial layer to maintain structural stability and regulate blood flow, alongside tanycytes—specialized ependymal glia that extend processes to contact capillaries, modulating hormone access and contributing to the blood-brain interface.^[10] Tanycytes, in particular, form a selective barrier that influences the uptake and release of signaling molecules at the vascular-neural boundary.^[11] The system exhibits a high density of nerve endings from hypothalamic neurons, which terminate in close proximity to the fenestrated capillaries, enabling direct secretion of releasing and inhibiting factors into the portal circulation.^[12] These axonal varicosities, often containing dense-core vesicles, cluster in the external zone of the median eminence for efficient neurohemal contact.^[13] Immunohistochemical analysis reveals CD31 (PECAM-1) as a key marker for endothelial cells lining the portal vessels, highlighting their continuity and density, while vimentin labels supporting glial elements such as tanycytes and astrocytes, underscoring their role in cytoskeletal support and barrier modulation.^[14]^[15]

Development

Embryonic formation

The embryonic formation of the hypophyseal portal system commences in human embryos during weeks 4-5, marked by the development of Rathke's pouch as an upward invagination of the oral ectoderm and the onset of initial hypothalamic vascularization from mesodermal precursors within the diencephalon.^[16]^[16] At this stage, the rudimentary vascular network begins to support the emerging neuroendocrine structures, with early capillaries forming around the developing hypothalamus as part of the broader neural tube vascularization process.^[17] By week 8, primary capillary loops emerge in the median eminence region, coinciding with further neuroectodermal invagination and the extension of vascular branches toward the infundibular area.^[18] These loops represent the initial primary capillary plexus, facilitating the foundational connectivity between hypothalamic neurons and the prospective anterior pituitary.^[18] The system achieves full establishment of portal veins by week 11.5, with an intact vascular pathway linking the hypothalamus to the anterior pituitary, paralleling the cytodifferentiation of pituitary cell lineages.^[19] Key anatomical milestones during this progression include the lengthening and fusion of the infundibular stalk, which integrates neural and vascular elements, and the emergence of short portal vessels that bridge the capillary beds.^[18]^[19] In comparative terms, the timeline in mice aligns closely but on a compressed scale: vascular development initiates around embryonic day 14.5 with branches supplying the hypothalamic region, and capillary networks form by day 16.5, supporting analogous neuroendocrine maturation.^[20]^[21]

Molecular regulation

The formation and differentiation of the hypophyseal portal system during embryonic development are tightly regulated by key signaling pathways and transcription factors that guide vascular sprouting, alignment, and specification in the hypothalamus and pituitary. Vascular endothelial growth factor (VEGF), particularly VEGF-A, plays a pivotal role in inducing the sprouting of fenestrated capillaries from the median eminence, the primary site of hypothalamic hormone release into the portal circulation. Studies in rat models have shown that VEGF-A expression peaks during early pituitary vascularization, promoting the development of primary capillary networks essential for the portal system's connectivity to the anterior pituitary pars distalis.^[22] This angiogenic factor facilitates the formation of specialized fenestrated endothelium, allowing efficient hormone transport while maintaining barrier properties in surrounding regions, as evidenced by continuous VEGF-dependent angiogenesis observed in the median eminence. Sonic hedgehog (Shh) signaling from the ventral diencephalon is essential for pituitary organogenesis, acting as a morphogen to induce ventral cell fates in the developing pituitary and regulate proliferation and differentiation of adjacent progenitor cells that support neuroendocrine development.^[23] In mouse models, disruption of Shh leads to pituitary hypoplasia, highlighting its role in establishing the anatomical foundation required for the hypophyseal portal veins. Transcription factors such as Foxg1 and Prop1 further refine endothelial and perivascular cell specification within the developing portal system. Foxg1 is expressed in early Rathke's pouch progenitors and modulates regional identity in the forebrain-hypothalamic axis.^[24] Prop1, a pituitary-specific factor, regulates the transition of stem cells toward hormone-producing lineages while promoting vascularization; Prop1-deficient mice exhibit reduced endothelial proliferation and poorly vascularized pituitary glands, underscoring its influence on perivascular niche formation.^[25] The Wnt/β-catenin pathway exerts control over portal vein elongation and branching, maintaining the fenestrated phenotype critical for the system's function. Activation of β-catenin in endothelial cells suppresses barrier-specific genes, favoring the permeable vasculature of the pituitary and circumventricular organs like the median eminence, as demonstrated in mouse genetic models where altered Wnt signaling disrupts capillary patterning.^[26] This pathway ensures directed vessel growth from hypothalamic tanycytes toward the pituitary, preventing over-branching or collapse during elongation. Much of the molecular data derives from mouse models, with human studies limited due to ethical constraints on embryonic tissue access. Studies on CNS vascular development indicate that Ephrin-B2/EphB4 signaling helps maintain vessel integrity by enforcing arterial-venous boundaries and preventing aberrant fusion, potentially applicable to the hypophyseal portal system.^[27]^[28]

Function

Hormone transport mechanisms

The hypophyseal portal system enables the diffusion-based transport of hypophysiotropic hormones from the terminals of hypothalamic neurons into the primary capillary plexus within the median eminence. These hormones, released into the extracellular space surrounding the fenestrated capillaries, diffuse across the endothelial barriers due to their small molecular sizes, allowing direct entry into the portal bloodstream without traversing the blood-brain barrier. Key examples include gonadotropin-releasing hormone (GnRH, molecular weight approximately 1.2 kDa), which stimulates gonadotropin release; corticotropin-releasing hormone (CRH, ~4.8 kDa), which promotes adrenocorticotropic hormone (ACTH) secretion; thyrotropin-releasing hormone (TRH, ~0.3 kDa), which induces thyrotropin (TSH) release; and growth hormone-releasing hormone (GHRH, ~3.7 kDa), which triggers growth hormone (GH) production. All these peptides have molecular weights under 10 kDa, facilitating their passage through the fenestrations.^[29]^[30]^[31] The portal system's high blood flow rate, typically ranging from 0.1 to 0.5 ml/min in mammals, ensures rapid delivery of these hormones to the secondary capillary plexus in the anterior pituitary, minimizing dilution and maintaining efficacy. This specialized circulation bypasses the systemic bloodstream, preventing widespread distribution and preserving hormone potency at the target site. As a result, hormone concentrations in portal blood achieve 10- to 300-fold higher levels compared to peripheral circulation—for instance, vasopressin levels in portal plasma can exceed 13,000 pg/ml versus 42 pg/ml systemically—enabling precise neuroendocrine signaling.^[32]^[33]^[34] The system's barrier properties confer selective permeability, with fenestrated endothelium permitting the passage of low-molecular-weight peptides while largely excluding larger molecules such as albumin (~66 kDa). This filtration is mediated by diaphragms in the fenestrae, which restrict macromolecules greater than approximately 10-20 kDa, thus protecting the pituitary microenvironment from non-specific plasma components and optimizing hormone-specific interactions with anterior pituitary cells.^[35]^[29]

Neuroendocrine integration

The hypophyseal portal system serves as a critical conduit for hypothalamic releasing and inhibiting hormones that modulate the secretion of anterior pituitary tropic hormones, including adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and growth hormone (GH).^[36] These neuropeptides, such as corticotropin-releasing hormone (CRH) for ACTH, thyrotropin-releasing hormone (TRH) for TSH, gonadotropin-releasing hormone (GnRH) for FSH and LH, and growth hormone-releasing hormone (GHRH) for GH, are synthesized in hypothalamic parvocellular neurons and delivered directly to the anterior pituitary via the portal vasculature to exert precise regulatory control.^[37] Inhibiting factors, exemplified by dopamine acting as a prolactin-inhibiting hormone (PIH) from tuberoinfundibular neurons, tonically suppress prolactin release from lactotrophs, preventing excessive secretion under basal conditions.^[38] Feedback mechanisms further refine this integration, with circulating hormones from target glands influencing hypothalamic neurons upstream of the portal system to maintain homeostasis. For instance, glucocorticoids like cortisol exert negative feedback by binding to receptors on CRH-producing neurons in the paraventricular nucleus, thereby reducing CRH synthesis and release into the portal circulation to dampen ACTH secretion.^[39] This closed-loop regulation ensures that elevated cortisol levels, arising from stress or circadian peaks, inhibit further hypothalamic drive, preventing overactivation of the hypothalamic-pituitary-adrenal (HPA) axis.^[40] Circadian and stress-induced variations in portal blood hormone pulses synchronize pituitary output with environmental and internal demands, enabling adaptive endocrine responses. Portal concentrations of CRH and other releasing factors exhibit ultradian pulses every 60-90 minutes, superimposed on a circadian rhythm with peak activity in the early morning, which aligns with diurnal fluctuations in ACTH and cortisol secretion.^[41] Under acute stress, rapid surges in portal CRH pulses amplify pituitary ACTH release, while chronic stress can alter pulse amplitude and frequency, influencing broader neuroendocrine rhythms.^[42] The hypophyseal portal system's role in central endocrine coordination is evolutionarily conserved across vertebrates, underscoring its fundamental importance in integrating neural and hormonal signals. In jawed vertebrates, from fish to mammals, analogous portal vascular networks facilitate hypothalamic regulation of pituitary tropic hormones, with conserved neuropeptides like CRH and GnRH ensuring reproductive, metabolic, and stress responses.^[43] This preservation highlights the system's efficiency in mediating brain-endocrine communication, as evidenced by similar portal-mediated GnRH delivery in teleosts and mammals. Recent optogenetic studies in rodents (2023-2025) have illuminated real-time modulation of pituitary rhythms through hypothalamic neurons linked to the portal system, advancing understanding of dynamic neuroendocrine integration. For example, optogenetic activation of CRH neurons in the paraventricular nucleus of mice elicits rapid, phasic increases in ACTH secretion, mimicking stress-induced portal pulses and revealing the temporal precision of hypothalamic-pituitary signaling.^[44] Similarly, targeted stimulation of GnRH neurons demonstrates synchronized oscillatory patterns that propagate via the portal vasculature to regulate pulsatile LH release, with implications for reproductive rhythmicity.^[45]

Clinical significance

Associated disorders

Pituitary adenomas, benign tumors arising from the anterior pituitary gland, can compress the hypophyseal portal vessels, impairing the delivery of hypothalamic releasing hormones such as gonadotropin-releasing hormone (GnRH) to the pituitary, which leads to hypopituitarism.^[46] This compression often results in GnRH deficiency, manifesting as hypogonadotropic hypogonadism with symptoms including infertility, reduced libido, and amenorrhea in women or erectile dysfunction in men.^[47]^[48] Sheehan's syndrome, characterized by ischemic necrosis of the anterior pituitary following severe postpartum hemorrhage, disrupts the hypophyseal portal blood supply due to the gland's vulnerability to hypovolemia, as the portal vessels derive from low-pressure systemic circulation.^[46]^[49] This necrosis commonly progresses to panhypopituitarism, affecting multiple hormonal axes and leading to deficiencies in growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, and gonadotropins, with approximately 50% of cases developing full panhypopituitarism.^[50]^[51] Erdheim-Chester disease, a rare non-Langerhans cell histiocytosis, involves foamy histiocytic infiltration of the hypothalamic-pituitary region, including the pituitary stalk, which can occlude the hypophyseal portal vessels and cause central diabetes insipidus through disruption of antidiuretic hormone transport.^[52]^[53] Diabetes insipidus occurs in approximately 47% of cases, frequently associated with pituitary stalk thickening that further contributes to anterior pituitary dysfunction by interrupting portal blood flow.^[54]^[52] Metastatic tumors, such as those from breast cancer, can invade the median eminence and pituitary stalk, altering hormone transport via the hypophyseal portal system and resulting in hypopituitarism through direct compression or destruction of vascular structures.^[55]^[56] Congenital malformations like septo-optic dysplasia involve absent or malformed hypophyseal portal vessels due to disrupted embryological development, often linked to mutations in the HESX1 gene, leading to hypopituitarism with features such as growth hormone deficiency and optic nerve hypoplasia.^[57]^[58] This condition has an incidence of approximately 1 in 10,000 births and represents a spectrum of midline brain defects affecting neuroendocrine function.^[59]^[60]

Diagnostic and therapeutic considerations

Diagnostic imaging of the hypophyseal portal system primarily relies on magnetic resonance imaging (MRI) with dynamic contrast enhancement, which allows assessment of portal blood flow and detection of vessel compression, such as in cases of pituitary adenomas.^[61] This technique visualizes the sequential enhancement patterns of the pituitary stalk and gland, correlating with the hypophyseal portal circulation's anatomy and function.^[62] Recent advancements in ultrahigh-field 7T MRI have improved spatial resolution to sub-millimeter levels (less than 1 mm), enhancing the detection of subtle vascular abnormalities in the portal system compared to standard 1.5T or 3T scanners.^[63]^[64] Endocrine testing provides indirect evaluation of hypophyseal portal integrity through stimulation protocols that assess pituitary responsiveness to hypothalamic signals transported via the portal system. The corticotropin-releasing hormone (CRH) stimulation test, for instance, measures adrenocorticotropic hormone (ACTH) release following CRH administration, with blunted responses potentially indicating disrupted portal delivery due to compression or infarction.^[65]^[66] This test is particularly useful in differentiating central from peripheral causes of adrenal insufficiency, reflecting the functional status of the hypothalamic-pituitary axis.^[67] Therapeutic management often involves transsphenoidal surgery to decompress tumors affecting the hypophyseal portal system, aiming to restore vascular patency and pituitary function with minimal invasiveness.^[68] For resulting hormone deficiencies, such as central hypothyroidism from TSH loss, lifelong replacement with levothyroxine is standard, dosed to normalize free thyroxine levels while monitoring for over-replacement.^[69]^[70] Emerging therapies target vascular dysregulation in the hypophyseal portal system, including anti-vascular endothelial growth factor (anti-VEGF) agents like bevacizumab for hypervascular pituitary lesions, which inhibit angiogenesis and reduce tumor vascularity in refractory cases.^[71] Post-treatment monitoring combines serial hormone assays to track pituitary recovery and functional MRI to evaluate portal flow restoration, with dynamic contrast sequences detecting improvements in vascular perfusion over time.^[72] These assessments guide adjustments in hormone replacement and detect residual or recurrent compression, such as from adenomas.^[73]

References

[1]
Functional Anatomy of the Hypothalamus and Pituitary - NCBI - NIH
Nov 28, 2016 · Although the hypothalamus comprises only 2% of the total brain volume, it is a key regulator of pituitary function and homeostatic balance.
[2]
Functional Anatomy of the Hypothalamus and Pituitary Gland
Blood from those capillaries drains into hypothalamic-hypophyseal portal veins. Portal veins are defined as veins between two capillary beds; the hypothalamic- ...
[3]
The Pituitary Gland and Hypothalamus – Anatomy & Physiology
This network, called the hypophyseal portal system, allows hypothalamic hormones to be transported to the anterior pituitary without first entering the systemic ...
[4]
Portal System - EdTech Books
The hypothalamic-hypophyseal portal system transports hormone-rich blood from capillaries in the hypothalamus to capillaries in the anterior pituitary gland.
[5]
Anatomy, Head and Neck, Pituitary Gland - StatPearls - NCBI - NIH
Structure and Function. GROSS ANATOMY OF THE PITUITARY GLAND. The pituitary gland undergoes rapid growth from birth to adult life to reach a weight of 500 mg.Introduction · Structure and Function · Embryology · Blood Supply and Lymphatics
[6]
Rapid sensing of circulating ghrelin by hypothalamic ... - PNAS
Fenestrated capillaries of the ME possess pores of 50–80 nm in diameter, encompassed by a permeable diaphragm composed of radial fibrils (26, 27). Passive ...
[7]
New aspects in fenestrated capillary and tissue dynamics ... - Frontiers
Electron microscopic studies have demonstrated the presence of trans-endothelial pores 30–80 nm in diameter in the sensory CVOs (Delmann, 1987; Dellmann ...
[8]
Anatomy, Head and Neck: Blood Brain Barrier - StatPearls - NCBI
EC tight junctions limit the paracellular flux of hydrophilic molecules across the BBB. The blood-brain barrier is present in all regions of the brain except ...
[9]
The Properties and Functions of Glial Cell Types of the ... - Frontiers
Jul 26, 2022 · The median eminence (ME) is part of the neuroendocrine system (NES) that functions as a crucial interface between the hypothalamus and ...
[10]
Pivotal role of median eminence tanycytes for hypothalamic function ...
Apr 15, 2017 · A population of specialized radial glial cells, the tanycytes, control exposure to blood-born signals by acting both as sensors and regulators of the ...
[11]
Median Eminence - an overview | ScienceDirect Topics
The median eminence is a specialized neurovascular interface containing the neurohemal contact zone where neurohormones regulating anterior pituitary secretion ...
[12]
Ultrastructure of Hypothalamic Neurons and of the Median Eminence
Sep 18, 2015 · These large 'neurosecretory' neurons were usually located near capillaries and characterized by their well developed Rough endoplasmic reticulum ...
[13]
[PDF] Nutritionally induced tanycytic plasticity in the hypothalamus of adult ...
PECAM-1 (CD31; endothelial cell marker that mediates cell-to-cell adhesion) staining was ... PECAM-1 (green) revealing the close proximity within capillaries of ...
[14]
Characterization of Vimentin-Immunoreactive Astrocytes ... - Frontiers
Jul 29, 2020 · We found that VIM-IR astrocytes generally express the canonical astrocytic markers Aldh1L1 and GFAP but that VIM-IR astrocytes are less abundant than GFAP-IR ...Missing: eminence | Show results with:eminence
[15]
Genetic Regulation of Pituitary Gland Development in Human and ...
Oct 16, 2009 · This review describes the complex genetic cascade of signaling molecules and transcription factors implicated in murine and human hypothalamo-pituitary ...Missing: timeline | Show results with:timeline
[16]
Central nervous system vascularization in human embryos and ...
Light and electron microscopy studies of human embryos suggest that microvasculature is present within the neural tube as early as the 5th gestational week (GW; ...
[17]
Paper - The development of the hypophysio-portal system in man (1933) - Embryology
### Summary of Hypophyseal Portal System Development in Humans (1933)
[18]
Observations on the Hypothalamo-Hypophyseal Portal Vasculature ...
Human fetuses, 11.5 to 16.8 weeks' gestational age, were perfused with silicone rubber compound to study the hypothalamo-hypophyseal portal system.Missing: vascularization embryo
[19]
Pathology of the Mouse - Pituitary Gland
Aug 12, 2018 · Starting at about 14 dpc, the internal carotid artery provides branches to the hypothalamic area to ultimately become the hypophyseal portal ...
[20]
Cyto-differentiation and portal vascular development in the mouse ...
The superior and anterior regions of the adenohypophysis become vascularized at 17 days p.c., when portal vessels extend from oral primary plexus to the pars ...Missing: embryonic | Show results with:embryonic
[21]
Gene Expression of Vascular Endothelial Growth factor-A ... - PubMed
Thus, the present study suggests that VEGF-A is involved in the development of the primary capillaries and in the vascularization of the pars distalis, but not ...
[22]
The hidden hedgehog of the pituitary - PubMed Central - NIH
... development of highly proliferative and vascularized undifferentiated tumors (257). ... Sonic hedgehog regulates crh signal transduction in the adult pituitary.
[23]
Pituitary stem cell regulation: who is pulling the strings? in
Mice with Cre-mediated conditional knockout of Notch2 under the control of Foxg1, a factor expressed in RP cells at E9.5 (Wang et al. 2010), showed no obvious ...
[24]
Cell proliferation and vascularization in mouse models of pituitary ...
In contrast, the Prop1-deficient mouse pituitaries are poorly vascularized and dysmorphic, with a striking elevation in apoptosis. At postnatal d 11, apoptosis- ...
[25]
Beta-catenin signaling regulates barrier-specific gene expression in ...
Apr 1, 2019 · Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain ...
[26]
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic ...
Sep 8, 2020 · Here, we identified the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.Missing: pituitary | Show results with:pituitary
[27]
EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis ...
Altogether, these results suggest that the ephrinB2/EphB4 pathway, but not TGF‐β1/TGF‐βR and Ang/Tie2, has a function in the development of normal angiogenesis ...Missing: pituitary | Show results with:pituitary
[28]
Hypophyseal Portal System - an overview | ScienceDirect Topics
Development of the hypophyseal portal system is necessary for hypothalamic releasing hormones to reach the pituitary gland and for transporting hormones to ...Introduction to the... · Anatomical Structure and... · Molecular and Cellular...
[29]
Physiology, Pituitary Gland - StatPearls - NCBI Bookshelf
... hypophyseal portal blood and are then carried down to the anterior pituitary. ... The hormones are transported in association with neurophysins proteins along ...
[30]
Chapter 2. Hypothalamic Control of Pituitary Hormones
These capillaries coalesce into the hypophyseal portal veins, which descend to the anterior pituitary and form a second capillary bed where the anterior ...
[31]
Hypophyseal Portal Blood Collection for Analysis of GnRH ... - J-Stage
Sequential sampling of hypophyseal portal blood was performed in the Shiba goat. ... flow rate due to head position [13]. Pulses of GnRH and LH were ...
[32]
K. P. McNatty, N. L. Hudson, S. Lun, D. A. Heath, L ... - Reproduction
secretory characteristics in hypophyseal portal blood of ovari¬ ... flow rate of portal blood was > 1.5 ml in 10 min, sampling at ... minimum detectable ...
[33]
high concentrations in monkey hypophyseal portal blood - PubMed
Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 ...Missing: review | Show results with:review
[34]
Development and Microscopic Anatomy of the Pituitary Gland - NCBI
Jul 21, 2025 · We provide an overview of the molecular drivers of pituitary organogenesis and illustrate the anatomy and histology of the mature pituitary.
[35]
Toward Multifactorial Hypothalamic Regulation of Anterior Pituitary ...
The hypothalamus regulates the secretion of anterior pituitary hormones via release of releasing hormones into the hypophysial portal vasculature.
[36]
Physiology, Hypothalamus - StatPearls - NCBI Bookshelf
It receives many signals from various regions of the brain and in return, releases both releasing and inhibiting hormones, which then act on the pituitary gland ...Missing: transport | Show results with:transport
[37]
Dopamine as a Prolactin (PRL) Inhibitor - Oxford Academic
Dopamine reaches the pituitary via hypophysial portal blood from several hypothalamic nerve tracts that are regulated by PRL itself, estrogens, and several ...Introduction · III. The Hypothalamo-Pituitary... · IV. Dopamine and the Pituitary...Missing: hypophyseal | Show results with:hypophyseal
[38]
Hypothalamic‐Pituitary‐Adrenal Axis—Feedback Control
Jul 1, 2015 · CRH acts on corticotropes by stimulating cAMP generation, and long term exposure (18 h) to glucocorticoids reduce cAMP levels in corticotropes, ...
[39]
Regulation of the hypothalamic-pituitary-adrenocortical stress ...
Stress responses are inhibited by negative feedback mechanisms, whereby glucocorticoids act to diminish drive (brainstem), promote trans-synaptic inhibition by ...
[40]
Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in ...
Dec 16, 2015 · Physiological experiments beginning in the 1970s demonstrated that secretion of the majority of hormones occurs in a pulsatile manner.
[41]
Circadian Clocks, Stress, and Immunity - Frontiers
Via the hypophyseal portal system, these reach anterior pituitary corticotrophs, which secrete adrenocorticotrophic hormone (ACTH). ACTH then acts at ...
[42]
Functional Pituitary Networks in Vertebrates - PMC - PubMed Central
Jan 27, 2021 · The pituitary is a master endocrine gland that developed early in vertebrate evolution and therefore exists in all modern vertebrate classes.
[43]
Optogenetic recruitment of hypothalamic corticotrophin-releasing ...
Jan 8, 2024 · Similar results have been reported in rodents, with repeated exposure to low doses of corticosterone in rats resulting in a depressive-like ...Missing: hypophyseal | Show results with:hypophyseal
[44]
Multi-dimensional oscillatory activity of mouse GnRH neurons in vivo
Jan 8, 2025 · This valuable study investigates the oscillatory activity of gonadotropin-releasing hormone (GnRH) neurones in mice using GCaMP fiber photometry.
[45]
Advances in understanding hypopituitarism - PMC - PubMed Central
Feb 22, 2017 · Pituitary insufficiencies due to impaired hypophyseal blood supply are in most cases caused by compression of the long portal blood vessels or ...
[46]
Hypogonadism in Male Patients with Pituitary Adenoma and Its ...
Jun 17, 2022 · When a tumor compresses the pituitary gland [41,42], symptoms of partial or total hypopituitarism may occur as a result of the insufficient ...
[47]
Pituitary Adenomas: From Diagnosis to Therapeutics - PMC
Apr 30, 2021 · Compression of pituitary structures can lead to hypopituitarism, which present as hypogonadism and GH deficiency [123]. In some cases ...
[48]
Pituitary Gland, Pars Distalis - Necrosis - Nonneoplastic Lesion Atlas
Aug 4, 2023 · Necrosis of the pars distalis has been associated with mechanical or other interruption of the blood supply from hypophysial portal vessels ...Missing: disruption | Show results with:disruption
[49]
A Case of Sheehan Syndrome Six Years Postpartum Presented With ...
Jan 19, 2023 · According to a cohort study in Costa Rica, approximately 50% of patients with Sheehan syndrome develop panhypopituitarism, whereas only adrenal ...
[50]
Sheehan Syndrome Unmasked by Adrenal Crisis Secondary ... - NIH
Sheehan syndrome is an established cause of secondary adrenal insufficiency and is one of the most common precursors of panhypopituitarism occurring secondary ...
[51]
The clinical spectrum of Erdheim-Chester disease - PubMed Central
Feb 9, 2017 · Patients often present with bone pain and fatigue, but ECD can manifest with multisystem involvement with cerebellar signs, diabetes insipidus, ...Missing: hypophyseal vein occlusion
[52]
Unveiling the Etiopathogenic Spectrum of Hypophysitis: A Narrative ...
This spectrum includes Langerhans cell histiocytosis and Erdheim–Chester disease. The hypothalamic–pituitary region is infiltrated in 5–50% of all patients ...
[53]
Progress in investigating pituitary stalk lesions: A review - PMC
Jan 10, 2025 · Erdheim-Chester disease is a rare non-Langerhans histiocytosis that ... diabetes insipidus and preservation of thyroid function after ...
[54]
Radiology of the Pituitary - Endotext - NCBI Bookshelf - NIH
Sep 14, 2023 · Metastases or lymphoma can occasionally involve the pituitary gland and stalk. The granular cell tumor is a rare tumor arising in the pituitary ...Missing: portal | Show results with:portal
[55]
Stereotactic Radiosurgery Hypophysectomy for Palliative Treatment ...
Dec 17, 2020 · This review highlights the role of hypophysectomy in alleviating advanced cancer pain, both in hormonal and nonhormonal malignancy.
[56]
Heterozygous HESX1 mutations associated with isolated congenital ...
Jan 1, 2001 · Accordingly, we have now scanned for HESX1 mutations in 228 patients with a broad spectrum of congenital pituitary defects, ranging in severity ...
[57]
HESX1 Mutations in Patients with Congenital Hypopituitarism - NIH
Mutations in the transcription factor HESX1 can cause Isolated Growth Hormone Deficiency (IGHD) or Combined Pituitary Hormone Deficiency (CPHD) with or without ...
[58]
Increasing incidence of optic nerve hypoplasia/septo-optic dysplasia ...
Nov 19, 2017 · We noted a dramatic rise in the annual incidence of ONH/SOD, which was strongly associated with poverty and northern communities.
[59]
Septo-optic dysplasia - PMC - PubMed Central
The main reported clinical findings are hypopituitarism (62–80%), with growth hormone deficiency being the commonest endocrine abnormality, visual impairment ( ...
[60]
High-Resolution DCE-MRI of the Pituitary Gland Using Radial k ...
Dynamic T1 weighted contrast enhanced sequence is considered to be the gold standard to evaluate this region. However, it does not allow assessment of intrinsic ...
[61]
Imaging of the pituitary: Recent advances - PMC - PubMed Central
Dynamic contrast MRI has been proven to be the best imaging tool in the evaluation of pituitary adenomas. A three-dimensional Fourier transformation gradient ...
[62]
High resolution pituitary gland MRI at 7.0 tesla - PubMed Central - NIH
To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.Missing: hypophyseal portal
[63]
Review of 7T MRI imaging of pituitary microadenomas: are we there ...
Mar 8, 2025 · 7T MRI is a promising tool for overcoming the difficulties encountered by conventional MRI, particularly in the case of Cushing disease.Missing: hypophyseal portal
[64]
Evaluation of the Hypothalamic-Pituitary-Adrenal Axis Function in ...
We review the most common endocrinologic investigations used in the evaluation of the HPA axis integrity and function.
[65]
Corticotropin-releasing Hormone Stimulation - Labcorp
The corticotropin-releasing hormone (CRH) stimulation test has been used as a diagnostic test in both adrenal insufficiency and Cushing syndrome.
[66]
Dexamethasone/Corticotropin-Releasing Hormone Test
Oct 15, 2025 · A CRH stimulation test alongside a high-dose dexamethasone suppression test enhances diagnostic accuracy with regard to the site of hormone ...
[67]
Surgical Treatment of Pituitary Adenomas - Endotext - NCBI Bookshelf
Mar 9, 2022 · Transsphenoidal surgery continues to provide optimal outcomes for non-prolactin secreting adenomas with a low incidence of major morbidity.Missing: decompression | Show results with:decompression
[68]
Hormone Replacement in Hypopituitarism Guideline Resources
Oct 1, 2016 · People who have central hypothyroidism should be treated with levothyroxine in doses sufficient to raise levels of the thyroid hormone free ...
[69]
Management of Hypopituitarism - PMC - PubMed Central - NIH
Thyroid-stimulating hormone replacement therapy follows the rules of primary thyroid gland failure with L-thyroxine replacement. Central diabetes insipidus is ...
[70]
Anti-VEGF Therapy in Refractory Pituitary Adenomas and Pituitary ...
In mice with hemorrhagic prolactinoma, monotherapy with anti-VEGF or DA can restrain tumor growth and improve vascular remodeling. Only the combination of anti ...Missing: hypervascular | Show results with:hypervascular
[71]
An Innovative Gene Therapy by Selective and Regulative ...
Dr. Zhu's project proposes an innovative and noninvasive strategy injecting a viral vector into the localized site to bind VEGF and inhibit VEGF pathogenic ...Missing: hypophyseal 2024
[72]
Serial assessments of anterior pituitary hormones in a case of mixed ...
MRI of the brain showed thickening of the pituitary stalk with slightly reduced signal hyperintensity in the posterior pituitary lobe on T1-weighted imaging.
[73]
8. Post Treatment Follow-up Evaluation
Indefinite endocrine follow-up is recommended in patients who undergo radiation therapy for NFPAs for serial surveillance of their pituitary function.Missing: portal | Show results with:portal