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Plasma

Plasma is the fourth , distinct from solids, liquids, and gases, formed when a gas is heated to such high temperatures that its atoms lose some or all of their electrons, resulting in a collection of positively charged ions and free electrons that collectively behave as a single . This ionized state makes plasma electrically conductive and highly responsive to electromagnetic fields, enabling unique collective motions among its particles, such as oscillations and waves. Unlike neutral gases, plasma exhibits quasineutrality overall but can develop regions of charge separation, leading to phenomena like electric currents and generation. The vast majority of visible matter in the universe exists in the plasma state, accounting for the majority of the baryonic (ordinary) matter beyond Earth's atmosphere, including stars, interstellar and intergalactic media, nebulae, and solar winds. On Earth, natural plasmas occur in lightning bolts, the aurora borealis, and the ionosphere, while laboratory-generated plasmas power fluorescent lights, neon signs, and plasma televisions. Plasmas are also central to advanced technologies, such as plasma torches for waste processing and low-temperature plasmas for etching and deposition in semiconductor manufacturing, where their properties enable precise material processing. In plasma physics, the discipline studying these states, key properties include Debye shielding, where surrounding charges screen electric fields over short distances, and plasma frequency, the natural oscillation rate of electrons, which determines how plasmas interact with electromagnetic waves. Plasmas can range from low-temperature, partially ionized forms (around 1-10 electron volts) in everyday applications to high-temperature, fully ionized ones exceeding millions of degrees in research, where they are confined using magnetic fields to mimic stellar conditions for clean energy production. This diversity underscores plasma's role in fundamental , forecasting, and emerging fields like plasma medicine, where controlled cold plasmas aid in and sterilization without damage. The term "plasma" is also used in other contexts, including the liquid component of blood in and various applications in and .

Physical sciences

State of matter

Plasma is the fourth , distinct from solids, liquids, and gases, consisting of a gas in which a significant of the particles are ionized, resulting in a of free electrons, ions, and neutral atoms or molecules. This ionized state allows plasma to conduct and respond to electromagnetic fields, and it constitutes over 99% of the visible in the , primarily in the form of , nebulae, and interstellar gas. Plasma forms through the process of , where sufficient energy is supplied to a neutral gas to strip electrons from atoms or molecules, creating positively charged ions and free electrons. This can occur via , by heating the gas to high temperatures (typically thousands of ) where collisions provide the necessary energy, or through non-thermal methods, such as applying strong that accelerate electrons to ionize the gas without significantly heating the heavier ions and neutrals. plasmas achieve ionization equilibrium, while non-thermal plasmas maintain distinct temperatures between electrons and ions. The transition from gas to plasma depends on energy thresholds related to the ionization potential of the constituent atoms, often described for equilibrium cases by the Saha ionization equation. For a simple hydrogen plasma, the equation relates the densities of electrons (n_e), protons (n_p), and neutral atoms (n_n) as follows: \frac{n_e n_p}{n_n} = \left( \frac{2\pi m_e k T}{h^2} \right)^{3/2} \frac{k T}{P} \exp\left( -\frac{I}{k T} \right), where S represents the Saha constant, m_e is the electron mass, k is Boltzmann's constant, T is temperature, h is Planck's constant, P is pressure, and I is the ionization energy. This equation quantifies the degree of ionization as a function of temperature and pressure, illustrating how higher temperatures favor plasma formation by overcoming the binding energy of electrons. Everyday examples of plasma include , where intense ionize air molecules during a discharge; auroras, formed by charged particles from the ionizing atmospheric gases; and neon signs, in which an electric current ionizes low-pressure gas to produce . The term "plasma" was coined in 1928 by physicist , drawing an analogy to the ionized component of blood that maintains neutrality despite containing charges.

Properties and behavior

Plasma exhibits a range of distinct types based on ionization degree and collision frequency. Fully ionized plasmas consist entirely of ions and electrons with no neutral particles, while partially ionized plasmas retain a significant fraction of neutrals alongside charged species. Collisional plasmas feature frequent particle interactions that dominate transport and equilibrium, whereas collisionless plasmas have mean free paths longer than system scales, allowing kinetic effects to prevail. A defining property of plasma is quasi-neutrality, where the overall charge remains balanced despite the presence of mobile electrons and ions, as the number densities of positive and negative charges are approximately equal on macroscopic scales. This balance arises because any local charge imbalance induces rapid redistribution of charges to restore neutrality. The characteristic distance over which such shielding occurs is the , given by \lambda_D = \sqrt{\frac{\varepsilon_0 k T}{n_e e^2}}, where \varepsilon_0 is the , k is Boltzmann's constant, T is the electron temperature, n_e is the , and e is the ; this length typically spans micrometers to centimeters in laboratory plasmas. Collective interactions in plasma stem from long-range forces between charged particles, which extend far beyond short-range collisions and lead to organized phenomena such as plasma waves and instabilities. These forces enable coherent oscillations and energy transfer across the system, distinguishing plasma behavior from neutral gases. For instance, electron density perturbations can propagate as Langmuir waves, while imbalances may trigger instabilities like two-stream modes that amplify perturbations. The plasma frequency represents the natural oscillation frequency of electrons in response to charge displacements, defined as \omega_p = \sqrt{\frac{n_e e^2}{\varepsilon_0 m_e}}, where m_e is the ; this frequency, often in the gigahertz range for typical densities, sets the timescale for many plasma responses and determines the for electromagnetic wave . In magnetized plasmas, where influence particle motion, the gyrofrequency \omega_c = eB / m_e dictates the rate of helical orbits around field lines, with B the strength. The Larmor radius, \rho = v_\perp / \omega_c (with v_\perp the perpendicular velocity), quantifies the of these orbits and is crucial for confinement, as particles remain bound to field lines when \rho is much smaller than the system size, enabling applications like magnetic devices. Plasmas are classified as ideal or non-ideal based on the coupling parameter \Gamma = (e^2 / 4\pi \varepsilon_0 a) / kT, where a = (3/4\pi n_e)^{1/3} is the interparticle ; ideal plasmas have \Gamma \ll 1, behaving like weakly interacting gases, while non-ideal plasmas with \Gamma \gtrsim 1 exhibit strong correlations akin to liquids or solids. Recent advancements include a 2025 study at , where AI analyzed trajectories in dusty plasmas—low-temperature systems with embedded microparticles—and uncovered unexpected non-reciprocal interaction laws, challenging prior assumptions about force symmetries and revealing new behaviors in many-body dynamics.

Biological and medical contexts

Blood plasma

Blood plasma is the straw-colored liquid component of , comprising approximately 55% of total and amounting to 3 to 5 liters in a typical . It acts as the suspending medium for blood cells and transports essential substances while helping maintain physiological balance. Plasma is the main component of from which interstitial fluid is derived through at capillary walls, with continuous exchange maintaining . The of is dominated by , which constitutes 90 to 92% of its volume, providing a for dissolved substances. The remaining 8 to 10% includes proteins such as (about 4.5 g/dL, maintaining ), globulins (including immunoglobulins for defense), and fibrinogen (essential for ), totaling 7 to 8% of plasma weight. Electrolytes like sodium (Na⁺, ~140 mEq/L), (Cl⁻, ~100 mEq/L), (K⁺, ~4 mEq/L), and (HCO₃⁻, ~24 mEq/L) ensure osmotic equilibrium and nerve function, alongside nutrients (e.g., glucose), hormones, vitamins, and waste products like . These components collectively support plasma's role as a dynamic carrier fluid. In laboratory settings, blood plasma is formed by centrifuging whole blood at speeds of 1,000 to 2,000 × g for 10 to 15 minutes, which sediments the denser cellular components—erythrocytes, leukocytes, and platelets—leaving the supernatant as cell-free plasma. This separation exploits differences in density, with plasma typically harvested using a pipette to avoid contamination from the buffy coat layer. In vivo, plasma circulates continuously, replenished by filtration and reabsorption in the kidneys and protein synthesis in the liver. Physiologically, , along with suspended blood cells, facilitates the transport of oxygen (primarily via erythrocytes), nutrients like glucose and to tissues, hormones such as insulin, and waste products including and to excretory organs. It buffers through systems like the bicarbonate-carbonic acid pair, stabilizing arterial at 7.35 to 7.45 to prevent disruptions in enzymatic activity. For clotting, fibrinogen converts to under action, forming hemostatic plugs, while globulins such as gamma globulins (antibodies) enable immune recognition and response against pathogens. These functions underscore plasma's integral role in . Plasma volume is tightly regulated to match about 40 to 50 mL/kg body weight, primarily by the kidneys through renin-angiotensin-aldosterone mechanisms that adjust sodium and , and by the liver, which produces to sustain colloidal and prevent fluid shifts. Disruptions, such as , trigger compensatory responses to restore balance. Historically, the fractionation of plasma advanced significantly in the 1940s when biochemist Edwin J. Cohn pioneered the cold ethanol method at Harvard, using low temperatures and ethanol gradients (8% to 40% v/v) to sequentially precipitate proteins like and globulins, enabling their purification for wartime medical applications. The global market for plasma-derived therapeutics is projected to reach approximately $38.71 billion in 2025, fueled by rising demand for plasma-derived therapies amid growing incidences of immune deficiencies and clotting disorders.

Therapeutic uses

Blood plasma is collected through , a process in which is drawn from a donor, centrifuged to separate the plasma from cellular components like red blood cells and platelets, and the cells are returned to the donor via the same needle to minimize loss of . This automated method allows for the collection of 625 to 850 milliliters of plasma per session, depending on the donor's weight and guidelines, with donors typically able to donate up to twice weekly in compensated systems. Globally, approximately 50 million liters of plasma are collected annually, primarily through a network of donation centers that support the of life-saving therapies. Processed plasma yields several key therapeutic products, including (FFP), which is used to treat clotting disorders by replenishing factors in patients with active bleeding or deficiencies. , derived from fractionated plasma, serves as a in cases of or , helping to stabilize and prevent damage in critically ill patients such as those with burns or . Immunoglobulins, also known as IVIG, are administered to individuals with immunodeficiencies to bolster immune function and prevent recurrent infections. These products stem from plasma techniques pioneered by Edwin Cohn in the 1940s, which enabled the separation of plasma into its protein components for targeted medical use. Therapeutic plasma exchange (TPE) involves removing a patient's plasma and replacing it with a substitute like or donor plasma to eliminate harmful antibodies and other pathogenic factors, commonly applied in autoimmune diseases such as or Guillain-Barré syndrome. A 2025 clinical trial conducted by the Buck Institute for Research on Aging demonstrated that TPE combined with intravenous immunoglobulin reduced participants' biological age by an average of 2.6 years, as measured by epigenetic clocks, highlighting its potential beyond traditional disease management to influence aging markers. Advancements in artificial blood substitutes include hemoglobin-based oxygen carriers derived from plasma-like formulations, with initiating the world's first clinical trials in 2025 for hemoglobin vesicles as a universal alternative, aiming to address transfusion shortages in emergencies. These trials, led by Medical University, involve administering 100-400 mL doses to healthy volunteers to evaluate safety and efficacy, with potential practical implementation by 2030. Despite these benefits, plasma therapies carry risks, including transfusion reactions such as febrile non-hemolytic events or allergic responses, which occur in about 1-2% of administrations and can range from mild fever to severe . Viral transmission, once a major concern, has been mitigated since the through rigorous donor screening and inactivation processes, reducing risk to less than 1 in 2 million units and hepatitis C to 1 in 2.3 million. Ethical considerations surround plasma donation, particularly the debate between compensated and voluntary systems, where payment—often $50-100 per session in the U.S.—can incentivize supply but raises concerns about of low-income donors who may donate frequently for financial need. This compensation model contributes to economic disparities, as plasma collection centers disproportionately cluster in impoverished areas, turning donation into a survival strategy for vulnerable populations while voluntary systems in prioritize but face supply shortages.

Technology and applications

Display and lighting

Plasma display panels (PDPs) are flat-panel displays that utilize small s filled with inert gases, such as and mixtures, to generate images through localized plasma discharges. In each , an excites the gas to form microdischarges, producing (UV) photons that strike RGB phosphors to emit visible , , and , enabling full-color reproduction. The process relies on a sustaining voltage of approximately 200 V applied across layers to maintain the discharges via , where the duration of pulses controls brightness and color intensity. Developed from the first single-pixel device invented in at the University of , PDPs evolved into large-scale consumer products by the late , with high-definition televisions reaching diagonals over 80 inches and resolutions up to . They dominated the market for large-screen TVs in the , offering sizes exceeding 100 inches for home entertainment and applications, prized for their ability to deliver sharp images without geometric distortion. However, production peaked around 2008–2010 before declining sharply due to competition from more energy-efficient LCD and technologies, which offered lower costs and thinner profiles; by 2013, major manufacturers like ceased PDP production. PDPs provided key advantages, including wide viewing angles up to 160 degrees horizontally and vertically, high contrast ratios exceeding 1000:1 for deep blacks and vibrant colors, and fast response times suitable for motion-heavy content like sports. These traits made them ideal for bright environments and large-format . Drawbacks included high power consumption—often several times that of LCDs—due to the energy required for gas , as well as phosphor degradation leading to brightness loss after about 30,000 hours of use and susceptibility to from static images. Despite these limitations, PDPs remain in niche and roles where is paramount. Plasma globes and lamps represent another illumination application, consisting of glass spheres partially evacuated and filled with like , , and . A central high-voltage generates a high-frequency , ionizing the gas to form colorful filamentary discharges that propagate as plasma filaments toward the grounded surface, creating dynamic, branching patterns responsive to touch. This design was pioneered in the early 1970s by student Bill Parker and researcher James Falk, building on Nikola Tesla's earlier discharge tubes from the 1890s. Initially used for scientific demonstrations, plasma globes found commercial success in the 1980s for educational tools in museums and classrooms, illustrating principles of electricity and plasma physics through their interactive, low-pressure discharge visuals. Today, they serve primarily in niche decorative and art installation contexts, valued for their aesthetic appeal over practical lighting, though their high-voltage operation limits broader adoption.

Industrial processing

Plasma etching and cleaning utilize glow discharge plasmas to fabricate semiconductors by removing materials through reactive ions and radicals. This process, integral to microchip production since the 1970s, enables precise patterning of integrated circuits by anisotropically and dielectrics without damaging underlying layers. and welding employ arc plasmas reaching temperatures up to 30,000°C to cut or join metals, offering high-speed precision for materials like and aluminum. Handheld plasma torches facilitate portable applications in automotive repair and , where the plasma melts and ejects along a controlled path. In fusion energy research, tokamaks and confine plasma at temperatures exceeding 100 million °C to achieve for power generation. The Princeton Plasma Physics Laboratory's Facility for Laboratory Reconnection Experiments (), unveiled in June 2025, studies in plasmas to improve confinement stability. Similarly, Germany's set a world record in May 2025 for the —a measure of plasma , , and confinement time—during discharges lasting over 30 seconds, advancing steady-state viability. Cold atmospheric plasma, operating at near-room temperatures, supports non-thermal such as sterilization of medical tools and in to enhance without heat damage. By 2025, it has expanded to manufacturing for improving adhesion and automotive surface activation to boost paint bonding on components, reducing defects in production. Environmental applications include , which converts into for through high-temperature , minimizing use and emissions. Plasma-based systems also reduce emissions in exhaust gases by dissociating nitrogen oxides into harmless components via electron-impact reactions. Recent advances feature compact laser-plasma accelerators, with a September 2025 technique enabling tabletop-scale particle acceleration for and . Laser-plasma interactions have further progressed, as demonstrated in October 2025 by a 30 cm device generating directional beams on demand, promising compact alternatives to large synchrotrons.

Arts and entertainment

Visual and sculptural art

Plasma sculptures utilize sealed vessels filled with inert gases and equipped with electrodes to generate dynamic electrical discharges, forming luminous filaments that evoke natural phenomena like . These works, which blend scientific principles with artistic expression, were pioneered by and Wayne Strattman, whose 2022 The Art of Plasma: Creating Lighted Sculpture with Gas, & provides a comprehensive to the medium's historical techniques and modern applications. A landmark exhibition, "The Art of Plasma" at the Museum of Neon Art in , in 2017 showcased kinetic plasma sculptures by 32 artists, highlighting the interplay of , gas, and to create mesmerizing, ever-changing light patterns that merge and . Artists employ specific techniques to control the visual effects, such as varying gas mixtures— for vibrant red-orange hues and for blue-violet tones—within the glass enclosures, powered by high-voltage transformers that shape the plasma into controlled, branching filaments. The Plasma Art Alliance, founded in 2020 with over 100 members worldwide, promotes plasma as a sculptural medium for creating objects that inspire curiosity and wonder, drawing on collaborative exhibitions to advance the form. Historically, plasma sculptures trace their roots to 1970s innovations in plasma globes, which served as precursors by demonstrating ionized gas discharges in glass for artistic and decorative purposes, evolving from early experiments by figures like Larry Albright. In recent developments, the 2025 PLASMA festival at the University at Buffalo's Department of Media Study featured performances, lectures, and screenings exploring plasma-inspired media art, underscoring the medium's ongoing role in contemporary installations.

Media and fiction

In science fiction, plasma is frequently depicted as a versatile medium for advanced weaponry, protective shields, and even exotic life forms. Blasters in the Star Wars franchise are canonically portrayed as plasma-based devices that fire energized particle bolts, superheating Tibanna gas to create contained plasmoids capable of cauterizing wounds upon impact. Similarly, the plasma rifle in the 1993 video game Doom functions as a high-energy that unleashes streams of superheated plasma projectiles, enabling rapid demon extermination in its hellish Mars setting. These representations emphasize plasma's destructive potential, often drawing on its real-world properties of and to lend plausibility to interstellar conflicts. Television series like Stargate SG-1 further popularized plasma in narrative contexts, with Goa'uld staff weapons and Tau'ri-developed firing discrete bolts of ionized gas that deliver thermal and kinetic damage, simulating the challenges of against advanced aliens. In film, while The Martian (2015) accurately grounds its survival tale in sources rather than speculative , it indirectly nods to plasma through depictions of ion propulsion systems that rely on ionized particles for maneuvering. Literature has long incorporated plasma-like concepts, with ' The War of the Worlds (1898) featuring Martian heat-rays that project intense heat and flames to incinerate human forces, an early fictional depiction evoking energy-based weapons. In music and gaming, plasma TV technology permeates pop culture as a relic of early-2000s futurism, referenced in songs lamenting technological obsolescence, such as those evoking the shift from bulky plasma screens to sleeker alternatives. Video games beyond Doom continue this motif, with plasma weapons symbolizing high-tech arsenal in titles like , where they embody alien superiority. Culturally, plasma has symbolized cutting-edge innovation since the 1980s, when early plasma display prototypes in advertisements promised immersive, gas-ionized visuals as the pinnacle of home entertainment. By the 2020s, this evolved into virtual reality simulations, such as PlasmaVR tools that immerse users in interactive plasma physics environments, reinforcing plasma's role as a gateway to futuristic exploration in digital media.

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