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Inferior hypogastric plexus

The inferior hypogastric plexus, also known as the pelvic plexus or pelvic ganglion, is a bilateral network of autonomic nerves located within the pelvic cavity that provides sympathetic and parasympathetic innervation to the pelvic viscera, including the bladder, urethra, rectum, and reproductive organs.^[1] This plexus forms a triangular meshwork of postganglionic sympathetic fibers, parasympathetic fibers, and visceral afferent nerves, situated in the extraperitoneal connective tissue on the pelvic sidewall, anterolateral to the mesorectum and adjacent to the rectum in males or the rectum and vagina in females.^[1] It arises from the convergence of the superior hypogastric plexus (conveying sympathetic input from T10-L2 levels via the hypogastric nerves), pelvic splanchnic nerves (parasympathetic fibers from S2-S4), and sacral splanchnic nerves (additional sympathetic contributions).^[1] The structure measures approximately 15-40 mm in length and 10-30 mm in thickness, with a variable morphology that can appear as a nervous lamina, network, or a combination thereof, positioned near the internal iliac artery and vein, posterior to the internal iliac vessels, and in close relation to the ureter, uterine artery, and pelvic lymph nodes.^[2]^[3] Functionally, the inferior hypogastric plexus distributes autonomic control to key pelvic structures through its major branches: the anterior division supplies the bladder and urethra (facilitating micturition and detrusor contraction), the middle division innervates the uterus, vagina, and seminal vesicles in males (supporting reproductive functions), and the posterior division targets the rectum and levator ani muscles (aiding defecation and pelvic floor tone).^[1] In females, these branches form distinct bundles—anterior for the bladder base, middle for the uterus and vagina, and posterior for the rectum via the mesorectum—while in males, similar divisions extend to the prostate and corpora cavernosa, emphasizing its role in both urinary and sexual physiology.^[3]^[2] Embryologically, it develops as a complex fibro-nervous network, with efferent fibers targeting the bladder at the ureterovesical junction superiorly and the bladder neck inferiorly, integrating sympathetic and parasympathetic inputs early in pelvic organogenesis.^[1] Clinically, the inferior hypogastric plexus is vulnerable during pelvic surgeries such as radical hysterectomy or prostatectomy, where injury can lead to urinary incontinence, erectile dysfunction, or anorectal issues due to its proximity to surgical fields and delicate fiber arrangement; nerve-sparing techniques aim to preserve these branches, particularly the bladder nerve branches running posterolateral to the distal ureter.^[1]^[2] It is also implicated in pelvic pain syndromes, such as those associated with endometriosis or prostatitis, where autonomic dysregulation contributes to chronic symptoms, and hypogastric plexus blocks can provide targeted analgesia.^[1]

Anatomy

Location and Structure

The inferior hypogastric plexus is a paired autonomic nerve plexus situated on the pelvic sidewall within the extraperitoneal connective tissue, positioned anterolateral to the mesorectum. In males, it lies directly on the rectum, whereas in females, it overlies both the rectum and the vagina. This plexus forms a triangular or fan-shaped structure, with its inferior edge extending from the fourth sacral nerve root to the inferior vesical artery, its posterior side along the sacral roots, and its cranial edge running parallel to the hypogastric nerve or posterior hypogastric artery.^[1]^[4] The plexus arises from the fusion of several neural components: the superior hypogastric plexus continuing via the paired hypogastric nerves, sacral splanchnic nerves originating from the sacral portion of the sympathetic chain (with preganglionic neurons from spinal levels T10 to L2), and pelvic splanchnic nerves emerging from sacral segments S2 to S4. These inputs converge to create a network of sympathetic, parasympathetic, and visceral afferent fibers without the presence of discrete ganglia. The structure is embedded within dense connective tissue, forming a solid proximal portion that varies in consistency from a unified plate to a more divisible network.^[1]^[4] Anatomical variations in the inferior hypogastric plexus are documented but limited in scope, primarily involving differences in size, symmetry between left and right sides, nerve thickness, and the degree of interconnection between its proximal and distal components. For instance, connections between dorsal and lateral nerve branches occur in approximately one-third of cases, with the overall morphology showing inter-individual variability in the fan-like spread and embedding within surrounding fascia. Comprehensive data on these variations remain sparse, highlighting the need for further cadaveric studies.^[1]

Anatomical Relations

The inferior hypogastric plexus is positioned laterally to the rectum and anterolaterally to the mesorectum, forming a key component of the pararectal space where it integrates with the surrounding fascia.^[1] This lateral relation places the plexus in close proximity to the rectal walls, particularly along the upper third of the rectum and vagina in females, where its branches extend toward the mesorectal fascia via the lateral ligaments.^[5] In males, it lies on the surface of the rectum, embedded within the subperitoneal fibro-fatty tissue.^[1] Medially, the plexus is situated relative to the internal iliac arteries and veins, coursing along their posterior aspect without direct vascular connections, while being dorsal to the parametric vessels, ureters, and uterine veins.^[2] The ureters cross anteriorly at the junction with the posterior uterine artery wall in the uterosacral ligament, marking the formation point of the plexus's fan-shaped structure.^[5] Anteriorly, it maintains relations with the base of the bladder, the prostate in males, and the cervix and vagina in females, where anterolateral branches connect to associated plexuses.^[1] Posteriorly, the inferior hypogastric plexus approximates the sacrum and sacral nerve roots (S2–S5), with its inferior edge aligning near the fourth sacral root and posterior side contacting the sacral roots directly.^[1] In surgical contexts, such as rectal resection or gynecological procedures like radical hysterectomy, the plexus's embedding within the pararectal fascia and close adhesion to the parietal pelvic fascia heighten its vulnerability to iatrogenic damage during dissection of the paracervix, rectovaginal ligament, or mesorectum.^[2] This positioning necessitates precise nerve-sparing techniques to avoid disruption of pelvic autonomic pathways.^[6]

Neural Inputs

The inferior hypogastric plexus receives sympathetic innervation primarily through postganglionic fibers from the sacral splanchnic nerves, which arise from the sacral sympathetic chain ganglia (typically S1-S4), with preganglionic sympathetic neurons originating from the intermediolateral cell column at upper lumbar levels (L1-L2).^[1]^[7] These fibers integrate with contributions from the superior hypogastric plexus, which divides at the sacral promontory into left and right hypogastric nerves, delivering additional sympathetic postganglionic elements to the inferior plexus.^[1]^[4] Parasympathetic inputs to the inferior hypogastric plexus are provided by preganglionic fibers from the pelvic splanchnic nerves, also known as nervi erigentes, which emerge directly from the ventral roots of spinal nerves S2-S4.^[1]^[4] These nerves join the hypogastric nerves to form the plexus, carrying cholinergic preganglionic fibers that synapse within the plexus or associated pelvic ganglia.^[1] Visceral afferent fibers enter the inferior hypogastric plexus alongside the sympathetic and parasympathetic pathways, originating from pseudounipolar neurons in the sacral dorsal root ganglia at levels S2-S5.^[1] These sensory fibers convey visceral pain, stretch, and other modalities from pelvic organs, traveling centrally via the dorsal roots to the spinal cord.^[1] The fiber composition of the inferior hypogastric plexus is predominantly unmyelinated, consisting of thin C fibers that facilitate autonomic transmission, with a mixture of adrenergic postganglionic sympathetic fibers and cholinergic preganglionic parasympathetic fibers coexisting within the plexus structure.^[8]^[1]

Neural Outputs

The inferior hypogastric plexus serves as the primary site for the integration and relay of efferent autonomic fibers to the pelvic region, where postganglionic sympathetic fibers—predominantly adrenergic and noradrenergic—emerge alongside postganglionic parasympathetic fibers, which are cholinergic in nature. Parasympathetic preganglionic fibers synapse in small ganglia associated with the subsidiary plexuses and target organs, while sympathetic fibers are postganglionic upon arrival. The sympathetic fibers originate from lumbar splanchnic nerves (T10–L2) via the hypogastric nerves, while parasympathetic fibers arise from sacral segments (S2–S4).^[1]^[9] From the inferior hypogastric plexus, efferent fibers form mixed autonomic branches that contribute to several subsidiary plexuses, including the vesical, middle rectal, inferior rectal, prostatic (in males), and uterovaginal (in females) plexuses. These pathways distribute without discrete ganglia for further relay within the main plexus structure, instead extending directly or via these smaller networks toward the pelvic viscera. The sympathetic outputs are primarily vasoconstrictive in character, whereas parasympathetic outputs facilitate secretory and motor activities through their cholinergic mediation.^[1]^[9]^[4] The neural outputs exhibit bilateral symmetry, with paired plexuses positioned on either side of the pelvic midline, allowing for potential crossover via anastomoses that interconnect the left and right sides. This symmetrical arrangement ensures coordinated efferent distribution, though variations in fiber density may occur, such as a slight predominance on the left at certain levels.^[1]^[8]^[9]

Distribution

The inferior hypogastric plexus distributes autonomic fibers to the pelvic viscera through a series of terminal branches that form subsidiary plexuses, providing innervation to key organs including the bladder, urethra, rectum, and reproductive structures.^[1] These branches arise from the main plexus located on the pelvic sidewall and extend anteriorly, intermediately, and posteriorly to reach their targets.^[3] In both sexes, the vesical plexus emerges from the anterior division of the inferior hypogastric plexus, traveling along the vesical arteries to innervate the bladder—specifically the detrusor muscle and trigone—and the internal urethral sphincter.^[1] The rectal plexus arises from the posterior division, supplying the lower third of the rectum via branches that penetrate the mesorectum.^[3] Perineal extensions from the plexus contribute to the innervation of the internal anal sphincter and perineal muscles, facilitating visceral control in the pelvic floor.^[1] In males, the distribution emphasizes reproductive innervation, with the prostatic plexus branching from the anterior and intermediate divisions to supply the prostate, seminal vesicles, and vas deferens, often coursing along the prostatic arteries; these fibers also extend to the corpora cavernosa of the penis for external genital innervation.^[1] In females, the uterovaginal plexus derives from the intermediate division, following the uterine artery to innervate the uterus, cervix, and upper vagina, with additional branches reaching the clitoris for external genital supply.^[3] Gender-specific differences in distribution reflect reproductive anatomy, with males exhibiting more extensive branching to accessory glands like the prostate and seminal vesicles, whereas females show denser uterovaginal networking for broader gynecological coverage.^[1] The plexus forms anastomoses with the pudendal nerve, allowing overlap between autonomic and somatic innervation in the perineum and external genitalia.^[1]

Physiology

Sympathetic Innervation

The sympathetic innervation of the inferior hypogastric plexus originates primarily from the thoracolumbar spinal cord segments T10-L2, with preganglionic fibers synapsing in the inferior mesenteric ganglion before forming postganglionic noradrenergic fibers that travel via the superior hypogastric plexus and hypogastric nerves to reach the inferior hypogastric plexus.^[1] Additional sympathetic input arrives through the sacral splanchnic nerves, which arise from the sacral sympathetic trunk and join the plexus on each side.^[1] This integration with central sympathetic outflow from the thoracolumbar region enables coordinated regulation of pelvic visceral functions, balancing excitatory and inhibitory effects on smooth muscle and glandular tissues.^[9] The postganglionic sympathetic fibers within the inferior hypogastric plexus are predominantly noradrenergic, releasing norepinephrine to act on α- and β-adrenergic receptors in target organs, thereby mediating vasoconstriction in the pelvic vasculature to control blood flow during various physiological states.^[9] In the male reproductive system, these fibers promote seminal emission as part of ejaculation by stimulating contraction of the vas deferens and seminal vesicles, facilitating the transport of spermatozoa and seminal fluid into the ejaculatory ducts.^[1] This sympathetic drive ensures the closure of the bladder neck during emission, preventing retrograde flow.^[9] Sympathetic activity also plays a key role in urinary bladder control, inhibiting detrusor muscle contraction to promote urine storage and simultaneously inducing contraction of the internal urethral sphincter to maintain continence.^[1] These effects arise from noradrenergic signaling that hyperpolarizes detrusor smooth muscle cells via β-receptors while exciting sphincter smooth muscle through α-receptors.^[9] Furthermore, sympathetic afferents within the plexus contribute to the transmission of visceral pain signals from pelvic organs, routing them through the hypogastric nerves and superior hypogastric plexus back to the thoracolumbar spinal cord for central processing.^[1] This pathway underscores the dual efferent and afferent roles of sympathetic components in pelvic homeostasis.^[9]

Parasympathetic Innervation

The parasympathetic innervation of the inferior hypogastric plexus arises from the craniosacral outflow, specifically preganglionic fibers originating in the lateral horn of the spinal cord at segments S2-S4, which travel via the pelvic splanchnic nerves (nervi erigentes) to join the plexus.^[1]^[10] These fibers synapse in intramural ganglia within the plexus or target organs, releasing acetylcholine as postganglionic neurotransmitters to mediate "rest and digest" activities in the pelvic viscera.^[11]^[1] Cholinergic postganglionic fibers from the plexus stimulate detrusor muscle contraction in the bladder, facilitating micturition by promoting urine expulsion through muscarinic receptor activation.^[1]^[12] These fibers also induce glandular secretion in the prostate and seminal vesicles, supporting seminal fluid production essential for reproduction.^[10]^[1] In sexual function, parasympathetic drive promotes erection by causing vasodilation and smooth muscle relaxation in the corpora cavernosa of the penis and the clitoris, while enhancing vaginal lubrication through increased glandular activity and vascular engorgement.^[11]^[10] Additionally, the parasympathetic components enhance rectal motility by increasing peristalsis and relaxing the internal anal sphincter, thereby facilitating defecation.^[11]^[12] These effects synergize with somatic nerves, such as the pudendal nerve, to coordinate complex pelvic functions like continence and expulsion.^[1]^[10]

Sensory Functions

The inferior hypogastric plexus serves as a key conduit for visceral afferent fibers that transmit sensory information, including pain, distension, and temperature sensations, from the pelvic organs. These afferents travel through both sympathetic pathways originating from the thoracolumbar region (T10-L2) via sacral splanchnic nerves and parasympathetic pathways from the sacral region (S2-S4) via pelvic splanchnic nerves, integrating into the plexus to relay signals toward the central nervous system.^[1]^[13] These visceral afferents provide essential feedback for sensations such as bladder fullness, rectal distension, and reproductive organ stimuli, enabling the perception of internal pelvic states without conscious localization. The plexus exclusively handles visceral sensory input, lacking any somatic sensory components that would involve skin or musculoskeletal structures.^[1]^[10] Sensory signals from the inferior hypogastric plexus contribute to referred pelvic pain, which may manifest in the lower abdomen or perineum, and are processed through integration with the sacral dorsal horn of the spinal cord. In chronic pelvic pain syndromes, these afferents can participate in central sensitization mechanisms, amplifying pain perception over time.^[1]^[14]

Clinical Significance

Pathological Conditions

The inferior hypogastric plexus is implicated in various chronic pelvic pain syndromes, where dysfunction arises from irritation, infiltration, or compression of its neural components, leading to persistent visceral and somatic pain. In endometriosis, ectopic endometrial tissue can directly involve the plexus, causing deep infiltrating lesions that result in severe dysmenorrhea, dyspareunia, and chronic pelvic pain through inflammatory and neuropathic mechanisms. Similarly, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in males is associated with plexus-mediated referred pain to the perineum, suprapubic region, and genitals, often involving heightened sympathetic activity and visceral afferent sensitization.^[1] These manifestations highlight the plexus's role in integrating sensory and autonomic signals for urogenital function, where pathological alterations amplify pain and impair coordination.^[1] Gender-specific symptoms include dyspareunia in females, often linked to endometriotic involvement of the plexus during intercourse. The sensory functions of the plexus in pain mediation are particularly vulnerable in these conditions, amplifying visceral hypersensitivity.^[1]

Surgical and Therapeutic Considerations

The inferior hypogastric plexus is vulnerable to iatrogenic injury during pelvic surgeries such as hysterectomy, prostatectomy, and rectal resection, potentially leading to urinary retention, bladder atony, and sexual dysfunction including impotence and dyspareunia.^[1] These complications arise due to the plexus's proximity to surgical fields, where disruption of its sympathetic and parasympathetic fibers impairs pelvic organ innervation.^[15] To mitigate risks, nerve-sparing techniques have been developed, emphasizing precise identification and preservation of the plexus through waterjet dissection or meticulous blunt separation, which accelerate recovery of normal urodynamics compared to non-sparing approaches.^[15] In radical hysterectomy, for instance, surgeons target the vascular and neural components of the parametrium to safeguard the plexus, reducing postoperative bladder dysfunction rates.^[16] Inferior hypogastric plexus blockade serves as a targeted intervention for managing chronic pelvic pain, particularly in conditions involving visceral hypersensitivity.^[17] The procedure involves injecting local anesthetics, such as bupivacaine, or neurolytic agents like phenol under fluoroscopic or CT guidance via transsacral or coccygeal approaches to interrupt pain transmission.^[18] Clinical studies report success rates of approximately 72.6% in pain reduction, with the block providing diagnostic confirmation and therapeutic relief lasting weeks to months, outperforming alternatives like acupuncture in intensity modulation.^[19] For cancer-related perineal pain, chemical neurolysis of the plexus offers prolonged analgesia with minimal systemic effects.^[20] Diagnostic imaging plays a critical role in preoperative planning to visualize the inferior hypogastric plexus and adjacent structures. Magnetic resonance imaging (MRI), particularly with 3D reconstruction, enables detailed mapping of the plexus's neural pathways, aiding in the avoidance of injury during complex resections.^[21] Computed tomography (CT) complements MRI by highlighting vascular relations and bony landmarks for precise needle placement in blocks or stereotactic navigation.^[22] Combined MRI-CT protocols achieve visualization rates of up to 80% for plexus components, facilitating personalized surgical strategies.^[23] Neuromodulation therapies indirectly influence inferior hypogastric plexus function to address refractory pelvic disorders. Sacral nerve stimulation, involving implantation of electrodes at S3-S4 roots, modulates afferent signals that converge on the plexus, improving voiding and sexual function in up to 70% of patients with pelvic pain or dysfunction.^[24] This approach alleviates symptoms by enhancing sacral parasympathetic outflow, which integrates with plexus-mediated visceral control, though direct plexus targeting remains investigational.^[25] Postoperative management focuses on preventing and treating complications from plexus injury through anatomical awareness and supportive care. Early catheterization and phosphodiesterase inhibitors can promote recovery, underscoring the value of intraoperative nerve monitoring.^[26] Comprehensive preoperative anatomical education reduces these risks by informing surgical trajectories.^[2]

References

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Anatomy, Abdomen and Pelvis: Inferior Hypogastric Plexus - NCBI
Dec 11, 2022 · The inferior hypogastric plexus forms a network of nerves that supply the viscera of the pelvic cavity.Introduction · Structure and Function · Embryology · Nerves
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Surgical Anatomy and Dissection of the Hypogastric Plexus in Nerve ...
Dec 29, 2023 · Inferior Hypogastric Plexus. The IHP is also known as the pelvic plexus or pelvic ganglion. It is a bilateral network of nerves, which lies in a ...
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The distribution of the inferior hypogastric plexus in female pelvis - NIH
The inferior hypogastric plexuses receive a parasympathetic component through the sacral nerves and a sympathetic one through anastomoses with the presacral ...
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Inferior hypogastric plexus: origin, course and function - Kenhub
The inferior hypogastric plexus, also known as the pelvic plexus or pelvic ganglion, is a paired collection of nerve fibers situated on each side of the rectum ...
[5]
Anatomy of the female pelvic nerves: a macroscopic study of ... - NIH
The inferior hypogastric plexus showed a pronounced uniformity in location and density (Figure 1), whereas the blood vessels were very variable. Branches of the ...
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The inferior hypogastric plexus (pelvic plexus) - PubMed
The objective of our study was to provide a better understanding of the inferior hypogastric plexus (IHP) and its anatomical relationships in order to spare it ...
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Inferior hypogastric plexus | Radiology Reference Article
Oct 19, 2022 · The inferior hypogastric plexuses are bilateral autonomic nerve plexuses and ganglia located in the side walls of the pelvis.
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Coexistence of adrenergic and cholinergic nerves in the inferior ...
Hypogastric nerves and pelvic splanchnic nerves join the inferior hypogastric plexus at the level of the superior angle and the posterior edge, proximal (supra- ...<|control11|><|separator|>
[9]
Review: Pelvic nerves – from anatomy and physiology to clinical ...
Within each pelvic compartment, bundles of nerve fibers diverge from the IHP to form organ-specific plexuses for pelvic autonomic nerves, namely the rectal, ...
[10]
Inferior Hypogastric Plexus - an overview | ScienceDirect Topics
The inferior hypogastric plexus refers to a network of nerves located in the lower pelvic region. It is formed by the fusion of various nerve fibers.
[11]
Module - Introduction to Autonomics, Part 2 - Medical Gross Anatomy
... inferior hypogastric plexus. Parasympathetic innervation to the colon and rectum increases peristalsis, and inhibits the internal anal sphincter to allow ...<|control11|><|separator|>
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Surgical Anatomy and Dissection of the Hypogastric Plexus in Nerve ...
Dec 29, 2023 · The SHP is a retroperitoneal structure, formed caudal to the level of the inferior mesenteric artery origin and located slightly to the left of ...
[13]
Anatomy, Abdomen and Pelvis, Splanchnic Nerves - StatPearls - NCBI
Mar 5, 2024 · The postganglionic fibers from this splanchnic nerve group constrict blood vessels in the hindgut and lumbar areas.
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Inferior Hypogastric Plexus Block Affects Sacral Nerves and the ...
Sep 29, 2012 · The inferior hypogastric plexus mediates pain sensation through the sympathetic chain for the lower abdominal and pelvic viscera and is thought ...
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Neuroanatomy of the pelvis: implications for colonic and rectal ...
Injury to detrusor branches of the pelvic nerve can cause detrusor denervation and urinary retention. In addition, injury to intrapelvic branches of the pelvic ...Missing: pathological conditions<|control11|><|separator|>
[16]
Identification and injury to the inferior hypogastric plexus in nerve ...
Sep 13, 2019 · Waterjet dissection of the inferior hypogastric plexus (IHP) resulted in a more rapid return of normal urodynamics than blunt dissection (control group)
[17]
Efficacy and oncologic safety of nerve-sparing radical hysterectomy ...
(D) Identification and preservation of the inferior hypogastric plexus composed of the hypogastric nerve and pelvic splanchnic nerve below the vascular part of ...
[18]
Inferior Hypogastric Block for the Treatment of Chronic Pelvic Pain
Feb 16, 2021 · 3.3. The IHP is a product of efferent sympathetic fibers arising from hypogastric and pelvic splanchnic nerves, preganglionic parasympathetic ...
[19]
A New Technique for Inferior Hypogastric Plexus Block - NIH
Inferior hypogastric plexus block is not commonly used in chronic pelvic pain patients due to pre-sacral location. Therefore, inferior hypogastric plexus is not ...
[20]
Inferior hypogastric plexus blockade versus acupuncture for the ...
Background: To compare the clinical efficacies of inferior hypogastric plexus blockade and acupuncture in the management of idiopathic chronic pelvic pain ...
[21]
Chemical neurolysis of the inferior hypogastric plexus for the ... - NIH
The inferior hypogastric plexus block is a good alternative neurolytic technique for the treatment of low pelvic and perineal pain.
[22]
Magnetic resonance neuroimaging promotes the preservation of ...
Dec 8, 2021 · Three-Dimensional Modelization of the Female Human Inferior Hypogastric Plexus: Implications for Nerve-Sparing Radical Hysterectomy. Gynecol ...
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A step towards stereotactic navigation during pelvic surgery - NIH
The superior hypogastric plexus, the hypogastric nerve, and the inferior hypogastric plexus could be identified bilaterally in 14 (70%), 16 (80%), and 14 (70%) ...
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Visualization of the pelvic nerves using magnetic resonance ...
This study evaluated the visualization of the pelvic nerves using magnetic resonance imaging (MRI) combined with computed tomography (CT)
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Apr 18, 2024 · The procedure involves implanting a neurostimulator that delivers electrical impulses to the sacral nerves, thereby effectively modulating ...
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The inferior hypogastric plexus is a major relay center and innervates the genital and reproductive tract, bladder, urethra, distal ureter, internal anal ...
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Bladder dysfunction after advanced pelvic surgeries - PubMed Central
Sep 30, 2025 · The superior hypogastric plexus (SHP) is the origin of sympathetic innervation to the bladder and other pelvic organs. This triangular network ...Introduction · Pelvic Neuroanatomy And... · Deep Endometriosis Surgery