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Internal vertebral venous plexuses

The internal vertebral venous plexuses, also known as the epidural venous plexus, form a network of valveless veins situated within the epidural space of the vertebral canal, extending longitudinally from the foramen magnum to the sacral hiatus.^[1] These plexuses consist of interconnected anterior and posterior components, with the anterior plexus positioned posterior to the vertebral bodies and the posterior plexus anterior to the laminae, creating a dense vascular network that drains venous blood from the spinal cord, meninges, vertebral bodies, and surrounding structures.^[2]^[3] Anatomically, the internal plexuses are characterized by their valveless nature, which permits bidirectional blood flow influenced by factors such as gravity, body position, and intra-abdominal or intrathoracic pressure changes, enabling them to serve as a critical collateral drainage pathway in cases of obstruction in major venous systems like the inferior vena cava.^[2] They receive tributaries from radicular veins (draining the spinal cord), basivertebral veins (emerging from the vertebral bodies), and intervertebral veins, before primarily draining into the external vertebral venous plexuses via foramina in the intervertebral spaces.^[1] Above the level of the second lumbar vertebra, drainage proceeds through lumbar veins to the inferior vena cava or the azygos and hemiazygos systems, while below L2, it routes via foraminal veins to the iliolumbar and common iliac veins.^[1] This highly anastomotic structure connects cranially with the intracranial venous sinuses and caudally with pelvic veins, forming part of the broader Batson venous plexus that facilitates communication between the cranial, thoracic, and pelvic venous systems.^[2]^[3] Functionally, the internal vertebral venous plexuses play an essential role in venous return from the central nervous system and vertebral column, preventing congestion and supporting hemodynamic stability during physiological variations in pressure.^[2] Their valveless design, however, predisposes them to distension under conditions of elevated intrathoracic or intra-abdominal pressure, such as in pregnancy, ascites, or tumors, which can increase the risk of complications during procedures like epidural anesthesia or spinal surgery.^[1] Clinically, these plexuses are notable for providing a hematogenous route for metastatic spread, particularly from pelvic malignancies like prostate cancer to the vertebral column and brain, bypassing the pulmonary filter due to their direct connections.^[2] Obstruction or thrombosis within the plexuses can lead to venous hypertension, spinal cord congestion, and ischemic myelopathy, underscoring their importance in neuroimaging and neurosurgical contexts.^[2]

Anatomy

Location

The internal vertebral venous plexuses, also known as the epidural venous plexuses, are located within the epidural space of the vertebral canal, forming a valveless network that surrounds the dural sac containing the spinal cord. This positioning extends longitudinally from the foramen magnum at the base of the skull superiorly to the sacral hiatus inferiorly, occupying the space between the bony walls of the vertebral canal and the dura mater.^[1]^[2] The anterior component of the internal vertebral venous plexuses consists of paired longitudinal veins situated immediately posterior to the posterior longitudinal ligament, running along the posterior surfaces of the vertebral bodies and intervertebral discs. In contrast, the posterior component comprises veins positioned anterior to the ligamenta flava, adjacent to the laminae of the vertebral arches. These anterior and posterior divisions are interconnected by transverse and longitudinal venous channels within the epidural space, creating a continuous meshwork.^[2]^[4] Cranially, the plexuses communicate with the dural venous sinuses, such as the sigmoid sinus, through emissary veins and the vertebral venous system around the foramen magnum, facilitating continuity with intracranial venous structures.^[2]^[5] Caudally, they continue beyond the sacral hiatus into the coccygeal and pelvic regions, integrating with extraspinal venous networks. The plexuses encircle the spinal dura mater laterally, anteriorly, and posteriorly without penetrating it, thereby forming a protective venous sleeve around the dural sac, spinal cord, and emerging nerve roots while maintaining separation by epidural adipose tissue and loose connective tissue.^[1]^[3] The internal plexuses also connect briefly with the external vertebral venous plexuses through intervertebral foramina.^[2]

Structure

The internal vertebral venous plexuses consist of a complex network of thin-walled, valveless veins arranged into anterior, posterior, and lateral components within the epidural space of the vertebral canal. These veins form interconnected channels that surround the dura mater, providing a mesh-like structure adapted to the constraints of the spinal environment.^[2] The anterior internal vertebral plexus forms a denser network positioned ventral to the spinal cord, running alongside the posterior longitudinal ligament and closely associated with the vertebral bodies via basivertebral veins that emerge from posterior foramina. This component includes paired longitudinal veins that contribute to a relatively constant and robust architecture across spinal levels.^[3]^[6] In contrast, the posterior internal vertebral plexus lies dorsal to the spinal cord, anterior to the ligamentum flavum, and exhibits greater morphological variability; it is particularly prominent in the thoracic region, where it often displays a symmetrical "inverted V" configuration formed by traversing veins. The lateral components, though sparser, link the anterior and posterior networks along the sides of the spinal canal.^[2]^[6]^[3] Histologically, the plexuses comprise endothelial-lined venous channels supported by a thin layer of smooth muscle and surrounded by epidural fat, rendering them highly compressible and prone to collapse under pressure variations.^[2]^[1] Segmental variations in density are notable, with the plexuses showing increased prominence and larger cross-sectional areas in the cervical and lumbar regions compared to the thoracic spine, where the posterior component predominates but overall volume decreases caudally.^[6]^[7]

Anastomoses

The internal vertebral venous plexuses form extensive anastomoses with surrounding venous structures as part of Batson's plexus, facilitating a complex network of interconnections along the spinal column. These plexuses connect to the external vertebral venous plexuses primarily through intervertebral veins and basivertebral veins, which pierce the vertebral bodies and allow for bidirectional flow between the intra- and extraspinal venous systems.^[2]^[8] Anastomoses with the veins of the spinal cord occur via radicular veins that accompany the spinal nerve roots, linking the internal plexuses to the anterior and posterior spinal veins as well as the pial venous plexus surrounding the cord.^[2]^[8] These radiculomedullary veins provide egress points for spinal cord drainage into the epidural space.^[2] Cranially, the internal vertebral venous plexuses communicate with the dural venous sinuses, including the sigmoid sinus and cavernous sinus, through emissary veins and the vertebral venous system around the foramen magnum.^[8] Caudally, connections extend to pelvic veins via sacral veins that drain into the internal iliac veins, forming part of the broader Batson's plexus extension.^[8] Additional caudal anastomoses involve the vertebral vein of the coccyx, linking the sacral segments to the ascending lumbar veins.^[9]^[8] Due to their valveless construction, these anastomoses enable retrograde flow under varying pressure gradients, supporting collateral circulation without directional restrictions.^[2]

Function

Blood Drainage

The internal vertebral venous plexuses, also known as the epidural venous plexus, primarily function to drain venous blood from various structures within the spinal canal. This network collects blood from the spinal cord via radicular veins, which include anterior and posterior radiculomedullary veins that pierce the dura to connect intrinsic spinal cord veins to the epidural space.^[2] It also receives drainage from the meninges through similar radicular tributaries and from the vertebral bone marrow via basivertebral veins that emerge from the vertebral bodies into the anterior portion of the plexus.^[1] In addition to these core sources, the plexuses gather venous return from the epidural fat and ligamentous structures, such as the posterior longitudinal ligament and ligamentum flavum, which are embedded within the epidural space along the length of the vertebral canal.^[2] This comprehensive collection ensures efficient removal of metabolic waste and maintenance of low-pressure venous flow in the confined spinal environment. Blood within the internal vertebral venous plexuses flows longitudinally along the spine through anterior and posterior longitudinal venous channels, receiving segmental inputs at each vertebral level, including from radicular veins accompanying the spinal nerves and from vertebral structures via basivertebral veins.^[2] These segmental contributions allow for a distributed drainage pattern that accommodates the entire spinal column, from the cervical to the sacral regions. The flow is influenced by posture and intrathoracic pressure, which can alter drainage efficiency due to the valveless nature of the system.^[2] Ultimately, the plexuses integrate with the systemic circulation by draining into regional veins, including the azygos and hemiazygos veins in the thoracic region, lumbar veins in the lower spine, and deep cervical veins superiorly.^[1] This connection facilitates the return of spinal venous blood to the heart via the superior and inferior vena cava systems.

Hemodynamic Role

The internal vertebral venous plexuses, characterized by their valveless structure, enable bidirectional and retrograde blood flow that responds to variations in intra-abdominal and intrathoracic pressures, such as those induced by the Valsalva maneuver.^[10] This adaptability allows the plexuses to facilitate dynamic venous return without directional constraints imposed by valves.^[10] These plexuses operate as a low-pressure system, with typical venous pressures ranging from approximately 8 to 15 mmHg, rendering them collapsible under elevated epidural pressures while permitting expansion during venous congestion to maintain flow.^[11] This compliance helps buffer pressure changes in the spinal canal, supporting overall hemodynamic stability.^[2] In spinal cord perfusion, the plexuses provide an alternative drainage pathway when cerebrospinal fluid pressure increases, thereby averting venous stasis and ensuring adequate venous outflow from neural tissues.^[12]^[13] Postural shifts influence flow within the plexuses, with gravitational effects promoting enhanced drainage through the longitudinal channels in the upright position compared to supine.^[14]^[15] In contrast to valved peripheral veins, the lack of valves in the internal vertebral venous plexuses promotes unimpeded communication with remote venous territories, including pelvic networks.^[10]^[13]

Clinical Significance

Metastatic Pathways

The internal vertebral venous plexuses, as part of Batson's plexus, play a critical role in the hematogenous dissemination of cancer metastases to the spine due to their valveless nature, which permits bidirectional flow and allows tumor emboli from pelvic, abdominal, and thoracic regions to bypass the pulmonary filtration and directly seed the vertebral bodies.^[16] This pathway was first recognized by Oscar V. Batson in 1940, who described the vertebral veins as a route for metastatic spread, initially highlighting their involvement in head and neck tumors reaching the vertebrae but later extended to other malignancies.^[17] The absence of valves facilitates retrograde venous flow, particularly during episodes of elevated intra-abdominal or intrathoracic pressure, such as coughing or straining, enabling tumor cells to enter the plexus from distant sites.^[18] Common primary malignancies utilizing this route include prostate, breast, lung, and renal cancers, where tumor cells embolize through the venous system to preferentially target the richly vascularized vertebral marrow.^[19] In prostate cancer, for instance, Batson's plexus accounts for 15 to 30 percent of metastases to the lumbar spine, contributing to its predilection for axial skeletal involvement over pulmonary sites.^[20] The spread typically manifests as hematogenous seeding within the vertebral bone marrow, resulting in osteoblastic lesions in prostate cancer—characterized by increased bone formation—or osteolytic lesions in breast, lung, and renal cancers, where bone resorption predominates due to tumor-induced osteoclast activation.^[21]^[22] Diagnostic imaging, particularly magnetic resonance imaging (MRI), is essential for identifying these metastases, revealing characteristic patterns such as T1-hypointense marrow replacement, T2-hyperintense edema, and enhancement post-contrast, with sensitivity exceeding 98 percent for spinal involvement via Batson's plexus.^[23]^[24] This route explains the high incidence of vertebral metastases in these cancers, underscoring the plexuses' pathological exploitation in oncology.^[25]

Pathological Conditions

Spinal epidural hematomas involving the internal vertebral venous plexuses are rare but serious complications, typically arising from rupture of the posterior internal vertebral venous plexus, which leads to accumulation of blood in the epidural space and subsequent compression of the spinal cord or nerve roots.^[26] This condition often occurs spontaneously or following minor trauma, with risk factors including anticoagulation therapy, vascular fragility, or sudden increases in intra-abdominal pressure such as from coughing or Valsalva maneuvers.^[27] The resulting hematoma can cause acute neurological deficits, including paraplegia, sensory loss, and bowel/bladder dysfunction, necessitating urgent surgical decompression to prevent permanent damage.^[28] Venous thrombosis within the internal vertebral venous plexuses is uncommon, attributed to the low-flow, valveless nature of this vascular network, which generally resists clot formation.^[29] However, it can develop in association with hypercoagulable states, such as those seen in malignancy, pregnancy, or inherited thrombophilias, leading to engorgement or partial occlusion of the plexus.^[30] Clinical manifestations typically include localized back pain, radiculopathy, and, in severe cases, cauda equina syndrome due to compression from the thrombosed veins.^[31] Anticoagulation and supportive care form the mainstay of treatment, with prompt recognition essential to avoid progression to infarction or chronic venous insufficiency. The internal vertebral venous plexuses facilitate the hematogenous spread of infections, particularly in the development of spinal epidural abscesses, where pathogens from distant sites seed the plexus via its extensive anastomoses.^[32] For instance, during episodes of bacteremia—often from sources like endocarditis or urinary tract infections—organisms such as Staphylococcus aureus can disseminate through the valveless venous channels, leading to purulent accumulation in the epidural space.^[33] This results in inflammatory compression of the spinal cord, presenting with fever, severe back pain, and progressive neurological deficits; early antibiotic therapy combined with surgical drainage is critical for reducing morbidity and mortality rates exceeding 5-10% in untreated cases.^[34] Congenital anomalies of the internal vertebral venous plexuses are infrequent, encompassing variations such as dilations or enlargements, which may cause space-occupying effects or compression of neural structures.^[35]^[36] These structural deviations, often identified incidentally on imaging, can increase susceptibility to hemodynamic imbalances, potentially exacerbating conditions like epidural venous engorgement in the presence of extrinsic venous obstructions.^[36] While typically asymptomatic, such anomalies have been linked to chronic radiculopathy or myelopathy in rare presentations, highlighting the need for anatomical awareness during surgical planning. Diagnostic evaluation of pathological conditions affecting the internal vertebral venous plexuses relies primarily on contrast-enhanced magnetic resonance imaging (MRI), which delineates hematoma, thrombosis, or abscess formation with high sensitivity by visualizing plexus enhancement patterns and surrounding soft-tissue changes.^[29] Computed tomography (CT) with intravenous contrast serves as a complementary modality, particularly in acute settings, to detect hyperdense hematomas or filling defects indicative of thrombosis, though it is less effective for early soft-tissue detail compared to MRI.^[35] These imaging techniques enable precise assessment of plexus involvement, guiding therapeutic interventions while minimizing invasive procedures.

References

[1]
Vertebral venous plexus | Radiology Reference Article
Nov 4, 2025 · The internal vertebral venous plexuses consist of two anterior and two posterior interconnecting longitudinal vessels lying in the epidural ...
[2]
Neuroanatomy, Spinal Cord Veins - StatPearls - NCBI Bookshelf
Jul 24, 2023 · The spinal venous system consists of a network of valveless veins grouped into three intercommunicating drainage systems that empty into extra spinal veins.
[3]
Veins of the vertebral column | Kenhub
After receiving blood from the region of the vertebral column, the internal venous plexus drains into the external venous plexus via the intervertebral veins.
[4]
Microsurgical anatomy of the internal vertebral venous plexuses
are located in a dehiscence of the periosteal layer, in the lateral part of the spinal canal. At each level, they joined the contralateral one at the midline by ...
[5]
Morphology of the human internal vertebral venous plexus - PubMed
The anterior part of the internal vertebral venous plexus is fairly constant. On the contrary, the posterior internal vertebral venous plexus showed a striking ...
[6]
Morphometrical Study of the Lumbar Segment of the Internal ... - MDPI
The internal vertebral venous plexus (IVVP) is a thin-walled, valveless venous network that is located inside the vertebral canal, communicating with the ...
[7]
Anatomy of Spinal Venous Drainage for the Neurointerventionalist
Apr 1, 2022 · The venous drainage of the spine can be separated into 3 compartments, from medial to lateral. The intradural compartment is further subdivided ...<|control11|><|separator|>
[8]
https://www.ajnr.org/content/43/4/517
[9]
The Spinal Cord - Meninges - Vasculature - TeachMeAnatomy
This space contains some loose connective tissue, and the internal vertebral venous plexus. As the spinal nerves exit the vertebral canal, they pierce the ...
[10]
The vertebral venous plexuses: the internal veins are muscular and ...
Oct 4, 2011 · The internal VVP was characterized by four main longitudinal channels with transverse interconnections; the maximum caliber of the longitudinal ...Missing: structure | Show results with:structure
[11]
The Craniocervical Venous System in Relation to Cerebral Venous ...
Oct 1, 2002 · Other factors affecting craniocervical venous drainage, such as Valsalva maneuvers or increases in abdominal pressure, could very well be ...
[12]
[PDF] The Cerebrospinal Venous System: Anatomy, Physiology, and ...
Feb 22, 2006 · The anatomic anastomoses between the vertebral venous plexuses and the intracranial venous system, first depicted by. Breschet,[3] have been ...
[13]
Positioning on surgical table - PMC - NIH
There are three components to Batson's plexus: the internal venous system ... The mean IVCP was 15.3 mmHg (range, 8.2–23.4 mmHg) when patients were ...
[14]
The influence of spinal venous blood pressure on cerebrospinal ...
Nov 28, 2023 · The data suggest that this continuum is present within a fairly modest pressure range of approximately 10 mm Hg. Presumably this continuum of ...
[15]
CSF–Venous Fistulas: Anatomy and Diagnostic Imaging | AJR
The vertebral venous plexus is an extensive valveless network of epidural veins that surrounds the thecal sac and the spinal nerve roots and helps dampen ...
[16]
A unifying hypothesis for hydrocephalus, Chiari malformation ...
Apr 11, 2008 · Conversely, obstruction to CSF flow causes localised pressure increases, which have an adverse effect on venous drainage. The Chiari ...Chiari Malformation · Hydrocephalus · Anencephaly And Spina Bifida<|separator|>
[17]
Human cerebral venous outflow pathway depends on posture and ...
During phase IIb of the Valsalva manoeuvre, internal jugular vein volume and pressure increased (P < 0.01); the jugular veins remained the predominant cerebral ...
[18]
Postural influence on intracranial fluid dynamics: an overview
Apr 13, 2023 · Normal values of CSF pressure, measured in the supine position, vary between 7 and 15 mmHg in adults. CSF pressure and ICP are dependent on many ...
[19]
Batson venous plexus | Radiology Reference Article | Radiopaedia.org
Aug 12, 2025 · These veins are important because they are believed to provide a route for spread of cancer metastases or infections to the spine 2.
[20]
THE FUNCTION OF THE VERTEBRAL VEINS AND THEIR RÔLE IN ...
THE FUNCTION OF THE VERTEBRAL VEINS AND THEIR RÔLE IN THE SPREAD OF METASTASES. Oscar V Batson ... 1940, under the title, “The Cerebrospinal Veins.” PMC Copyright ...
[21]
Batson's plexus and retrograde venous spread of malignancy
We present a detailed pictorial review of imaging of patients from our oncology centre showing retrograde venous spread to the paravertebral vessels.
[22]
View of Metastasis of lung cancer through Batson's plexus
Many malignancies, like prostate, colon, and breast cancer, metastasize through Batson's plexus (vertebral venous plexus). Although lung cancer is one of the ...
[23]
Neurologic Complications of Prostate Cancer - AAFP
May 1, 2002 · From 15 to 30 percent of metastases are the result of prostate cancer cells traveling through Batson's plexus to the lumbar spine. Metastatic ...
[24]
The Osteoblastic and Osteoclastic Interactions in Spinal Metastases ...
Bone destruction from osteoclast activity leads to the release of growth factors from the matrices which possess the ability to act on metastatic cancer cells.Spinal Metastasis In Pc · The Rank/rankl/opg Signaling... · The Role Of Vegf In...
[25]
[Translated article] Imaging diagnosis of vertebral metastasis
Metastases can be osteolytic (breast, lung, colon, thyroid, and kidney), blastic (prostate and neuroblastoma), or mixed (breast and lung). The most frequent are ...
[26]
Spinal Metastasis - StatPearls - NCBI Bookshelf
Among the routes mentioned above, hematogenous spread through Batson's plexus system is the most common pathway for tumor embolization and spinal invasion.
[27]
Use of Imaging in the Management of Metastatic Spine Disease With ...
The purpose of this article is to describe the role of imaging in the management of metastatic spine disease with percutaneous ablation and vertebral ...
[28]
Physiopathology of Spine Metastasis - PMC - NIH
The diffusion through Batson venous system is the principal process of spinal metastasis, but the dissemination is possible also through arterial and lymphatic ...
[29]
Spontaneous spinal epidural hematoma and spinal cord infarction ...
Oct 29, 2013 · The source of bleeding appears to be the dorsal internal vertebral venous plexus (IVVP). Case description: A 65-year-old female patient with ...
[30]
Spontaneous epidural hematoma of the spine associated with oral ...
It is generally caused by a rupture of the postero-internal vertebral venous plexus secondary to minor barotrauma such as cough, peridural catheter insertion...
[31]
Clinical Features, Management, and Prognostic Factors of ... - PubMed
Conclusions: SSEH is a rare but serious illness. It is more likely that SSEH arises from a ruptured internal vertebral venous plexus. The initial neurologic ...
[32]
Epidural venous thrombosis as differential diagnosis in back pain ...
Epidural venous thrombosis is a rare clinical entity with a characteristic constellation of findings in contrast-enhanced MRI, which should be considered in ...
[33]
Epidural venous plexus enlargements presenting with ... - PubMed
This report describes enlarged epidural veins in patients with inferior vena caval thrombosis or obstruction presenting with radicular syndromes.
[34]
Transient cauda equina compression syndrome and ... - PubMed
Transient cauda equina compression syndrome and headache caused by internal vertebral venous plexus engorgement in a teenage female with vena cava inferior ...
[35]
Spinal epidural abscess post-ureteroscopy: a case report - PMC
Apr 24, 2025 · Cells or infection may spread to the subdural space via the internal vertebral venous plexus due to lack of posterior valves and contiguous ...
[36]
Imaging and surgical findings of spinal epidural abscess caused by ...
Although it is possible that the offending candida gained access to spinal canal via regional venous plexuses as there is no valves in those veins so blood ...Abstract · 3. Results · 4. Discussion
[37]
Epidural Abscess - StatPearls - NCBI Bookshelf - NIH
An epidural abscess is an infection within the epidural space anywhere in the brain or spinal cord. Epidural abscesses occur as a result of infections ...
[38]
Vertebral venous system abnormalities identified with magnetic ...
Mar 23, 2017 · Eleven cases (prevalence 12%) showed abnormal enlargement of the internal vertebral venous plexus (10/11 unilaterally, 1/11 bilaterally) ...Missing: thrombosis | Show results with:thrombosis<|control11|><|separator|>
[39]
Congenital dilation of the cervical epidural venous plexus - PubMed
Lesions like this are absolutely rare, presumably of congenital origin and have not been described before. The lesion was treated by feeder occlusion applying ...Missing: vertebral | Show results with:vertebral