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Sal Hepatica

Sal Hepatica is an effervescent mineral salt laxative and tonic originally developed by the Bristol-Myers Company in 1895, designed to replicate the taste and therapeutic effects of natural Bohemian spa waters for relieving constipation and combating acidity.^[1]^[2] Introduced as the company's first breakthrough product and dubbed the "poor man's spa," Sal Hepatica quickly gained popularity, achieving annual sales of $500,000 within a decade of its launch.^[1] To meet growing demand, Bristol-Myers expanded production in 1906 by acquiring land in Hillside, New Jersey, for a dedicated facility.^[1] The product was promoted as a gentle, dual-action remedy that not only promoted bowel regularity but also neutralized excess stomach acid, positioning it as a household essential for digestive health.^[2] Throughout the early 20th century, Sal Hepatica was aggressively marketed through print advertisements, radio broadcasts, and endorsements citing medical surveys, though some claims—such as its efficacy against colds—faced regulatory scrutiny from the Federal Trade Commission in the 1940s, leading to restrictions on unsubstantiated health assertions.^[3] It remained a staple in Bristol-Myers' portfolio, contributing significantly to the company's growth into a major pharmaceutical firm, until its discontinuation in 1974.^[1]

History

Development and launch

Bristol-Myers was founded in 1887 when William McLaren Bristol and John Ripley Myers, two graduates of Hamilton College and former fraternity brothers, each invested $5,000 to acquire the struggling Clinton Pharmaceutical Company in Clinton, New York. The partners aimed to develop and market proprietary products on a national scale, moving beyond local pharmaceutical manufacturing to create branded remedies for broader distribution. This acquisition marked the beginning of their efforts to build a viable enterprise in the competitive American drug industry of the late 19th century.^[1]^[4] Sal Hepatica emerged around 1895 as Bristol-Myers' first major national product, formulated as an artificial saline laxative designed to replicate the therapeutic effects of natural mineral waters from Bohemia. Inspired by the renowned spa waters of Europe, particularly those from Carlsbad (now Karlovy Vary), the product was created to provide an accessible alternative to expensive European treatments, allowing users to dissolve the salts in water for a similar tonic and laxative experience at home. Marketed initially as the "poor man's spa," it represented an innovative effort to democratize spa-like health benefits through a convenient, powdered preparation.^[1]^[5]^[6] Early production of Sal Hepatica was centered in New York, but growing demand prompted expansions to support larger-scale manufacturing. In 1906, Bristol-Myers purchased seven acres of land in Hillside, New Jersey, specifically to enhance facilities for producing the product, reflecting the company's commitment to meeting rising market needs and establishing a more robust operational base. This move laid the groundwork for further growth in the years following its initial launch.^[1]

Commercial success and marketing

Sal Hepatica quickly rose to prominence as a national bestseller for Bristol-Myers following its initial launch, achieving widespread commercial success by 1903 after modest early sales.^[7] This breakthrough product helped propel the company forward, with gross profits exceeding $1 million for the first time in 1924, reflecting its strong market position and expansion to 26 countries.^[7] The product's marketing efforts began intensifying around 1897, featuring extensive advertising campaigns in magazines, newspapers, and later radio broadcasts that highlighted its sparkling effervescence, gentle laxative action, and purported benefits for liver function and overall vitality.^[8] These promotions often portrayed Sal Hepatica as a convenient, antacid-laxative alternative to harsher remedies, emphasizing prompt relief without discomfort and its role in mimicking natural mineral spa waters.^[1] By the 1930s, campaigns sponsored popular radio programs, such as those hosted by Eddie Cantor and Fred Allen, to reach broad audiences and reinforce its image as essential for daily health maintenance.^[9] Branding played a key role in its appeal, with the name "Sal Hepatica" derived from the Latin "sal" for salt and "hepar" meaning liver, evoking traditional associations with liver tonics while also nodding to the hepatica flower, whose lobed leaves resemble the organ.^[10] Positioned as a natural, effervescent tonic, it was marketed to consumers seeking accessible wellness solutions, available over-the-counter in pharmacies throughout the United States and major cities worldwide.^[11] This ubiquitous presence in drugstores underscored its status as a household staple during the early to mid-20th century.^[12]

Decline and discontinuation

Following World War II, the pharmaceutical landscape transformed with the widespread adoption of antibiotics, synthetic drugs, and prescription medications, leading consumers to favor evidence-based treatments over traditional patent medicines like saline laxatives.^[13] Bristol-Myers, Sal Hepatica's manufacturer, pivoted toward ethical pharmaceuticals, mass-producing penicillin and expanding research into modern therapeutics, which diminished emphasis on older over-the-counter products.^[13] A key regulatory blow came in 1943 when the Federal Trade Commission ruled against Bristol-Myers, allowing claims for Sal Hepatica only as a laxative while barring assertions of its efficacy against colds or related symptoms, severely restricting its broad marketing appeal and contributing to sales erosion.^[3] By the mid-20th century, Sal Hepatica faced stiff competition from newer laxatives, including stimulant agents like bisacodyl (introduced in 1953) and stool softeners such as docusate (available since the 1950s), which offered gentler effects without the electrolyte imbalances associated with saline formulations.^[14] Its outdated composition—primarily sodium sulfate and other mineral salts—proved less suitable amid evolving standards for safety and efficacy, prompting discontinuation in 1974.^[1] Today, Sal Hepatica survives solely in archival contexts, with original packaging and samples preserved in historical collections such as those of the American Institute of the History of Pharmacy and medical museums.^[15]

Composition and formulation

Key ingredients

Sal Hepatica's formulation was designed to replicate the mineral content of Bohemian spa waters, such as those from Carlsbad, using a blend of inorganic salts and acids to produce an effervescent solution when dissolved in water.^[5] The primary ingredients, as determined by analysis of the product in 1914, consisted of sodium sulfate (Glauber's salt), sodium phosphate, tartaric acid, sodium bicarbonate, sodium chloride (common salt), and a small amount of lithium phosphate. These components provided the core saline and acidic elements responsible for the product's effervescent reaction, with sodium sulfate serving as the principal cathartic salt, sodium bicarbonate and tartaric acid generating carbon dioxide upon mixing, and sodium phosphate, chloride, and lithium phosphate contributing to the overall mineral profile.^[16] The original recipe contained no non-active additives such as flavorings or aromatics, emphasizing a pure mineral salt composition to mimic natural Bohemian sources.^[16] Over time, the formula underwent minor adjustments; a 1921 analysis noted a reduction in sodium phosphate, increases in sodium bicarbonate and tartaric acid, and the elimination of citric acid, which may have been present in very early versions, to refine the effervescent balance and palatability.^[16] These changes occurred prior to the 1940s and maintained the product's status as a simple saline laxative without introducing synthetic additives.^[16]

Preparation and dosage forms

Sal Hepatica was formulated as an effervescent powder primarily packaged in metal tins or glass bottles for consumer use throughout its history.^[17]^[18] The standard preparation required dissolving 1 to 2 teaspoons of the powder in 8 ounces of water to produce a fizzy, palatable drink.^[19]^[20] In later years, the product was also available in tablet form, supplied in glass bottles.^[21] No liquid variants were produced, maintaining the focus on dry powder or compressed tablet formats to preserve the effervescent reaction upon mixing.

Pharmacology and mechanism

Active components and effects

Sal Hepatica's therapeutic profile derives from its key active components, primarily sodium sulfate, sodium bicarbonate, tartaric acid, sodium phosphate, and sodium chloride, which interact to produce laxative and antacid effects. Sodium sulfate acts as the primary osmotic laxative, poorly absorbed in the intestines and drawing water into the lumen to increase stool volume and promote peristalsis, thereby facilitating bowel evacuation.^[22] Sodium bicarbonate contributes an antacid effect by neutralizing excess gastric hydrochloric acid, forming sodium chloride, water, and carbon dioxide, which helps alleviate acidity-related discomfort.^[23] Tartaric acid facilitates effervescence through its reaction with sodium bicarbonate upon dissolution in water, generating carbon dioxide gas that aids in rapid dispersion and palatability of the preparation.^[24] The inclusion of sodium phosphate enhances the osmotic action similarly to sodium sulfate, pulling additional fluid into the intestines. Sodium chloride contributes to the overall saline osmotic effect and helps mimic the composition of natural mineral waters. Trace amounts of lithium carbonate were also included to replicate Bohemian spa waters, but did not significantly contribute to the therapeutic effects.^[10] Overuse of these osmotic components carries risks, including dehydration from excessive fluid loss into the gut, potentially leading to electrolyte imbalances such as hypokalemia or hyponatremia if fluid intake is inadequate.^[25]

Clinical mechanism of action

Sal Hepatica exerts its laxative effects primarily through the osmotic action of its saline components, including sodium sulfate, sodium phosphate, and sodium chloride, which are poorly absorbed in the gastrointestinal tract. These salts remain in the intestinal lumen, creating an osmotic gradient that draws water from the surrounding tissues into the bowel, thereby increasing fluid volume, softening the stool, and stimulating peristalsis to promote evacuation. This process typically begins within 30 minutes to 6 hours after oral administration, with the duration of action limited to the time required for bowel movement, often resolving within a few hours.^[22]^[26]^[27] As an antacid, Sal Hepatica's sodium bicarbonate component neutralizes excess gastric hydrochloric acid by reacting to form sodium chloride, water, and carbon dioxide, which raises the intragastric pH and alleviates acid-related discomfort. This reaction occurs rapidly in the stomach, providing prompt relief from acid indigestion without significantly altering overall systemic pH due to the localized nature of the effect. The effervescent formulation enhances dispersion and contact with gastric contents, facilitating efficient neutralization.^[27]^[28] Systemic absorption of Sal Hepatica's components is minimal, with the majority of the saline salts acting locally in the gut and being excreted in the feces following osmotic fluid retention. Any absorbed bicarbonate may contribute to a mild alkalinizing effect, historically linked to claims of enhancing urinary excretion of uric acid by increasing urine pH and solubility, though this systemic impact is secondary to the primary gastrointestinal actions. Efficacy can be influenced by hydration status, as adequate fluid intake supports the osmotic mechanism, while dehydration may diminish water draw into the intestines.^[22]^[26]

Uses and efficacy

Primary indications

Sal Hepatica was primarily indicated as a saline laxative for the relief of occasional constipation, functioning through osmotic action to draw water into the intestines and promote bowel movements without griping or habit formation. This made it suitable for short-term use in maintaining digestive regularity, particularly for adults experiencing mild, infrequent episodes of constipation.^[8] In addition to its laxative properties, Sal Hepatica was recommended for secondary uses such as alleviating mild acid indigestion and gastric hyperacidity often accompanying constipation, owing to its alkalinizing and antacid effects from key ingredients like sodium bicarbonate.^[8] It served as a gentle aperient to support overall digestive health, appealing to individuals seeking a non-irritating option for symptom relief without reliance on stronger stimulants. The product was targeted toward adults and children over 6 years old requiring occasional, non-habit-forming intervention for bowel regularity, with adjusted dosages for children (e.g., half the adult dose for ages 6-12).

Historical claims and modern evaluation

In the early 20th century, Sal Hepatica was promoted for a range of therapeutic effects beyond its primary laxative function, including treatment for colds through its purported diuretic and eliminative properties.^[16] Advertisements also claimed it relieved rheumatism by eliminating uric acid from the system, positioning it as a solvent for uric acid deposits associated with gout and related conditions.^[16]^[29] Additionally, it was marketed as a liver stimulant and tonic, beneficial for hepatic disorders, drawing on its composition of sodium phosphates and other salts to support liver function.^[16] These claims persisted in promotional materials until at least the 1930s, with the U.S. Federal Trade Commission issuing a 1943 ruling that prohibited representations of Sal Hepatica as an effective treatment for colds, limiting its advertising to laxative efficacy.^[3] Contemporary medical evaluation dismisses these extended historical claims due to a lack of supporting evidence, recognizing sodium phosphate-based formulations like Sal Hepatica solely as short-term osmotic laxatives for occasional constipation relief, in line with FDA guidelines for over-the-counter use.^[30] Following its discontinuation in 1958, no clinical studies validate benefits for colds, rheumatism, uric acid dissolution, or liver tonification, with modern pharmacology attributing any perceived non-laxative effects to placebo or incidental diuretic action rather than targeted therapeutic mechanisms.^[31] In comparative terms, sodium phosphate laxatives are now less favored than stimulant options like bisacodyl or bulk-forming agents such as psyllium, due to their superior safety profiles for regular use and lower risk of dependency or adverse effects.^[32] Updated safety assessments highlight risks associated with chronic or excessive use of sodium phosphate formulations, including electrolyte imbalances such as hyperphosphatemia, hypocalcemia, and dehydration, which can lead to acute kidney injury or cardiac complications, particularly in vulnerable populations like the elderly (over 55), children under 6, or those with renal impairment, heart problems, or dehydration risks.^[30] The FDA mandates strict dosage limits and warnings on sodium phosphate products to mitigate these hazards, emphasizing their unsuitability for prolonged administration.^[31]^[33]

Regulation and legacy

Regulatory actions

Prior to the enactment of the Federal Food, Drug, and Cosmetic Act in 1938, Sal Hepatica was marketed as a patent medicine with limited federal oversight, allowing broad therapeutic claims under the lax Pure Food and Drug Act of 1906, which primarily addressed adulteration and misbranding but lacked requirements for pre-market safety or efficacy demonstrations.^[34] The 1938 Act introduced stricter controls on drug labeling, advertising, and safety, shifting responsibility to the Food and Drug Administration (FDA) and compelling manufacturers like Bristol-Myers to substantiate claims for over-the-counter products.^[34] Initial Federal Trade Commission (FTC) scrutiny began in the 1930s with a complaint filed in 1931 against Bristol-Myers, targeting misleading claims for Sal Hepatica including remedies for rheumatism and systemic purification. This led to cease-and-desist orders in the 1930s, setting precedents for further enforcement. In 1943, the FTC issued a modified cease-and-desist order prohibiting unsubstantiated advertising claims for Sal Hepatica, including its use as an effective treatment or preventive for colds, influenza, and hay fever; remedies for rheumatism; and broader assertions of systemic purification or protection against diseases beyond its established roles as a laxative and antacid.^[3]^[35] The order, enforced under Section 5 of the FTC Act, required the company to limit representations to scientifically supported functions, such as mild laxative effects from its sodium phosphate and sodium bicarbonate components, while barring any implication of superior therapeutic properties not verified by evidence.^[35] Post-war, Bristol-Myers complied with the FTC order by revising Sal Hepatica's labeling and promotional materials to emphasize only its antacid and laxative benefits, aligning with the evidence-based standards emerging under FDA oversight.^[35] No major product recalls were issued for Sal Hepatica throughout its commercial lifespan from 1895 to 1958.^[1]^[10] These regulatory interventions influenced Bristol-Myers' strategic pivot toward prescription pharmaceuticals, including the 1943 acquisition of penicillin production facilities, marking a transition from consumer patent medicines to regulated ethical drugs.^[1]

Cultural and historical impact

Sal Hepatica holds an iconic place in early 20th-century American advertising, embodying the exuberant promotion tactics of the patent medicine era while adapting to the era's growing regulatory scrutiny following the 1906 Pure Food and Drug Act.^[7] Launched in 1895 by Bristol-Myers as a mineral salt laxative mimicking the effects of Bohemian spa waters, it was marketed as the "poor man's spa," making therapeutic mineral treatments accessible to the average consumer through effervescent powders dissolved in water.^[1] Its campaigns, which emphasized gentle relief from constipation and acidity without harsh griping, appeared in magazines and newspapers, often featuring testimonials and lifestyle imagery that promised renewed vitality. By the 1930s, Sal Hepatica sponsored popular radio programs, such as the Fred Allen show produced by Young & Rubicam, leveraging entertainment to embed the product in everyday American culture during the Great Depression.^[36] This blend of bold claims and eventual compliance with labeling requirements highlighted its role in bridging the unregulated patent medicine boom—characterized by secret formulas and exaggerated cures—with the more scientific, regulated pharmaceutical industry.^[7] The product's commercial success profoundly influenced Bristol-Myers' evolution into a major pharmaceutical powerhouse, providing the financial foundation for groundbreaking innovations. As the company's first national bestseller by 1903, Sal Hepatica generated substantial revenues, with annual sales reaching $500,000 within a decade and contributing to gross profits exceeding $1 million by 1924.^[1]^[7] These funds enabled international expansion to 26 countries and investments in research and development, culminating in the 1943 acquisition of Cheplin Laboratories to produce penicillin on a large scale for World War II efforts—the first antibiotic to be mass-manufactured in the U.S.^[7] This legacy underscores Sal Hepatica's indirect contribution to modern medicine, transforming a consumer laxative into a catalyst for pharmaceutical advancements that saved countless lives. Today, Sal Hepatica endures as a collectible artifact of medical and advertising history, with vintage tins, bottles, and advertisements preserved in institutions that document the evolution of over-the-counter remedies. Examples include glass bottles and labeled containers held in the Medical History Collections at the University of Melbourne, which illustrate the product's packaging and branding from the 1920s to 1930s.^[21] These items reflect persistent marketing tropes in laxative promotions, such as promises of "regularity" for overall health and happiness, often tied to themes of personal well-being and social success. In the broader historical context of 1930s America, Sal Hepatica exemplified the "cure-all" trend in patent medicines, positioned alongside remedies like Lydia E. Pinkham's Vegetable Compound for alleviating common ailments from digestive issues to fatigue, amid a cultural reliance on self-medication during economic hardship.^[37]

References

[1]
Company history timeline - Bristol Myers Squibb
Sep 24, 2025 · Bristol-Myers purchases seven acres in Hillside, New Jersey, for expanded production of Sal Hepatica. Squibb Biologics. 1914.
[2]
SCIENCE AND SAL HEPATICA - JAMA Network
Sal Hepatica is the mineral salt laxative that does two things, not just one; it rids the body of waste and it also combats acidity.
[3]
FTC RULING COVERS SAL HEPATICA CLAIMS; Commission Bars ...
The Bristol-Myers Company of Hillside, NJ, may represent its product Sal Hepatica as a competent laxative but not as an effective treatment for colds.
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Bristol-myers Squibb Company | Encyclopedia.com
Bristol-Myers was founded in 1887 by two former fraternity brothers, William McLaren Bristol and John Ripley Myers. They each invested $5,000 in the Clinton ...Missing: springs Carlsbad
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Jan 12, 2005 · Content Description. A laxative mineral salt that, when dissolved in water, reproduced the taste and effects of the natural mineral waters ...
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[PDF] The Foreign Service Journal, December 1931
at Wiesbaden—Vichy—Carlsbad, and other well- known European Spas. Sal Hepatica is the efficient practical equivalent of. Europe's famous saline spas. It acts ...
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Aug 27, 2013 · While the new product, christened Sal Hepatica, sold modestly at first, by 1903 it was a bestseller. "By 1924, Bristol-Myers' gross profits ...
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Sal Hepatica advertisement - Full view - UWDC
Since 1897, patients have been keeping sparkling SaL HEPATICA handy. They like its prompt, gentle relief of constipation.
[9]
Radio Active: Advertising and Consumer Activism, 1935-1947 ...
In an ad for the sponsor of the Fred Allen show, a laxative called Sal Hepatica, the ad announcer explains to Fred when he introduces the commercial that “we're ...
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Artifacts From Medical History - The Driver Suit Blog
Feb 9, 2018 · Bristol and Myers first national product was named Sal Hepatica, a laxative mineral salt that, when dissolved in water, reproduced the taste ...
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The company first made drugs for physicians, but after World War I it concentrated on the laxative Sal Hepatica and other over-the-counter proprietary drugs and ...Missing: development invention Bohemian mineral springs Carlsbad launch patent early Hillside Jersey 1914
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Bristol-Myers Squibb (BMS) - History & Problematic Products
... Bristol and John Ripley Myers founded the second half of the company in 1887. ... Within a decade, they developed a national bestseller: “Sal Hepatica,” a mineral ...Missing: 1895 springs Carlsbad launch Hillside 1914
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Sales of such Bristol-Myers items as Sal Hepatica (a laxative mineral ... new manufacturing facilities in Hillside, New Jersey. In 1915, Henry Bristol ...Missing: invention 1895 springs Carlsbad 1914
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Aug 17, 2023 · Docusate is a medication utilized for managing and treating constipation. Belonging to the stool softener class of drugs, it reduces the surface tension.
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Some of the ingredients used in these cure-alls included opiates or strong laxatives such as calomel (mercury chloride) and alcohol. Remedies touted to cure ...
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[PDF] Nostrums and Quackery and Pseudo-Medicine - Center for Inquiry
Sal Hepatica.-This has been on the market for many years. At first it was ... Glauber's salt (sodium sulfate) with minute proportions of washing soda and table ...
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Antique Box of SAL HEPATICA Laxative Medicine Bristol Myers ...
In stockNOS early 20th century box of four tubes. As shown. Estate Fresh. Please message us with any questions. Measurements: 2.5" x 2.5". All of our listings are 100% ...
[18]
Vintage FULL Glass Bottle Sal Hepatica Original Bristol Myers Co ...
In stockVintage FULL Glass Bottle Sal Hepatica Original Bristol Myers Co. Laxative ; Quantity. 1 available ; Item number. 286140818469 ; Country of Origin. United States.Missing: invention date 1895 Bohemian mineral springs Carlsbad patent
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Page 54 — Virginian-Pilot 27 April 1956 — Virginia Chronicle ...
... Sal Hepatica Take just teaspoon of sparkling antacid Sal Hepatica in a glass of water andteel how fast it relieves excess stomach acidity The mild taxation ...
[20]
Therapeutics - JAMA Network
Sal Hepatica, J. A. M. A. 62: 472 (Feb. 7) 1914. 4. Pluto Concentrated ... following composition : sodium chlorid, 1 part ; sodium bicarbonate, 2 parts ...
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Bottle of Sal Hepatica - Explore the collection
Bottle of Sal Hepatica. Maker Bristol-Myers Company Pty. Ltd. (estab. Circa 1941, closed Circa 1970s) Date 1920s-1930s. Description Sal hepatica: Four ounce ...
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Saline laxatives are poorly absorbed or nonabsorbed osmotic preparations that result in the secretion of water in the intestines to maintain isotonicity with ...
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Feb 12, 2024 · Mechanism of Action · Absorption: Following oral administration, excess bicarbonate is absorbed, resulting in metabolic alkalosis and ...Mechanism of Action · Administration · Adverse Effects · Contraindications
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Formulation, Characterization and Physicochemical Evaluation of ...
Usually, these tablets are prepared by compressing the active ingredients with mixture of sodium bicarbonate and organic acids such as citric and tartaric acid.
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Mechanism of Action and Toxicities of Purgatives Used for ... - NIH
Sodium sulfate itself contributes to the laxative effect of the mixture. ... Magnesium Citrate is an osmotic laxative that, as a sole agent, has not been ...
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Chloride, the principal inorganic anion in the extracellular fluid compartment, is essential in maintaining fluid and electrolyte balance, and is a necessary ...
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Long-term stimulant laxative use is correlated with the loss of haustral folds in the colon; this could indicate neuronal or muscular injury caused by these ...
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To prepare magnesium sulfate oral solution, dissolve appropriate dose of the crystals in at least 240 mL water; may add lemon juice to mask bitter taste and ...
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Antacids - StatPearls - NCBI Bookshelf - NIH
Aug 8, 2023 · Mechanism of Action · Ability to promote angiogenesis · Bind to bile acids · Inhibit peptic activity · Suppress Helicobacter pylori growth.Continuing Education Activity · Indications · Mechanism of Action · Adverse Effects
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In its simplest form, antacids are drugs that are usually alkaline substances that are used to neutralise excess acid in the stomach.Missing: Sal Hepatica laxative
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[PDF] Federal Trade Commission Decisions Vol. 18
... Carlsbad and VIchy, but It also radiates great quantities of oxygen In your ... Sal Hepatica, Squibb's Epsom Salts, Squibb's Laxative Salt, Squibb's.
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ORAL SALINE LAXATIVE CHERRY LAXATIVE - DailyMed
Ask a doctor before use if you · have abdominal pain, nausea, or vomiting · have kidney disease · have heart problems · have a sudden change in bowel habits lasting ...Missing: contraindications | Show results with:contraindications
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[PDF] The Propaganda for Reform
an éliminant of irritating toxins." "Sal Hepática is a saline combination containing the alterative and laxative properties similar to the natural'Bitter Waters ...
[34]
FDA warns of possible harm from exceeding recommended dose of ...
Jan 8, 2014 · Using more than one dose in 24 hours of over-the-counter (OTC) sodium phosphate drugs to treat constipation can cause rare but serious harm to the kidneys and ...
[35]
[PDF] Final Administrative Order (OTC000032) Over-the-Counter ...
May 2, 2023 · FDA also added a warning for all sodium phosphate/sodium biphosphate products not to exceed the recommended dosage unless directed by a doctor.Missing: historical modern evaluation
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Feb 19, 2016 · Oral sodium phosphate products (OSP) are used for bowel cleansing prior to colonoscopy or other medical procedures.Missing: historical modern evaluation
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Jan 30, 2023 · The following chronology describes some of the milestones in the history of food and drug regulation in the United States.
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This volume contains findings, orders, and stipulations from July 1, 1943 to December 31, 1943, including tables of cases and stipulations.Missing: Hepatica | Show results with:Hepatica
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History: 1930s - Ad Age
Sep 14, 2003 · Y&R supervised the casting, writing and production of the Fred Allen and Jack Benny programs for Sal Hepatica and Jell-O, respectively. JWT ...
[40]
Cure-alls were popular in the 1930s - The Newark Advocate
Dec 20, 2014 · ... Sal Hepatica was a laxative that would keep you regular. The Lydia Pinkham compound was a great thing if you felt blue and rundown, Ostrex ...