Craniopagus twins
Craniopagus twins constitute the rarest variant of conjoined twinning, wherein monozygotic twins remain fused at the cranium due to incomplete embryonic separation.[1] This anomaly occurs in approximately 4 to 6 cases per 10 million live births, representing 4 to 6 percent of all conjoined twin presentations, with only about 25 percent surviving the neonatal period.[2][3] Anatomically, affected twins typically exhibit extensive sharing of dural venous sinuses, arterial vasculature, and, in some instances, interdigitated cortical tissue or thalamic connections, which underpin profound physiological interdependence.[4][5] Classification schemes, such as those delineating partial versus total fusion and orientations like frontal, occipital, or parietal, guide assessment of separation feasibility, though such procedures demand staged multidisciplinary interventions with historically elevated risks of neurological deficits or mortality exceeding 50 percent in complex cases.[6][7] While non-separated craniopagus twins face constrained longevity from circulatory overload or infection, advances in neuroimaging, endovascular embolization, and reconstructive techniques have enabled occasional successful separations, particularly in vertical fusions performed before one year of age.[8][9]Definition and Classification
Types of Fusion
Craniopagus twins are classified by the extent and orientation of cranial fusion, with partial fusions limited to superficial skull unions lacking substantial shared dural venous sinuses (SDVS) and total fusions involving extensive calvarial continuity with shared venous structures and brain compression.[10][11] Partial fusions typically occur at frontal sites, less commonly occipital or vertical biparietal, featuring smaller junctional diameters and potential incomplete bone layers, while total fusions often span parietal or vertex regions with circumferential venous sinuses.[10][11] A widely referenced system distinguishes partial angular (PA), partial vertical (PV), total angular (TA), and total vertical (TV) types based on fusion orientation and depth.[11] In PA types, angular orientation (inter-twin longitudinal angle <140°) predominates with localized frontal or occipital unions, independent venous drainage, and milder cerebral deformities, enabling earlier surgical separation with lower mortality.[11] PV types exhibit vertical stacking at the vertex or biparietally, with separate calvarial convexities, no SDVS, and minimal brain distortion, also favoring straightforward separation.[11] TA fusions involve parietal sites with angular asymmetry, significant SDVS (often sharing 30% of posterior fossa), and distorted hemispheres, necessitating staged procedures due to complex venous channels.[11] TV types, formerly encompassing O'Connell's Types I–III, feature near-continuous crania housing four hemispheres separated by a transverse dural septum, with subtypes defined by axial rotation: Type I (<40°, facing same direction), Type II (140–180°, opposite directions), and Type III (intermediate 40–<140°); these carry high risks from absent falx cerebri, flattened brains, and extensive SDVS.[11][10] Site-specific distributions include frontotemporal/frontoparietal (25%), parietal (45%), and occipital/occipitoparietal (30%) unions, influencing vascular and neural sharing.[12] Overall, craniopagus represents 2–6% of conjoined twins, occurring in approximately 1 per 2.5 million births.[10][11]Incidence and Risk Factors
Craniopagus twins represent the rarest subtype of conjoined twinning, accounting for 2% to 6% of all conjoined twin cases.[10] The overall incidence of conjoined twins is estimated at 1 in 50,000 to 1 in 200,000 live births worldwide.[1] Consequently, the incidence of craniopagus twins is approximately 1 in 2.5 million live births, though regional variations may exist, with higher reported rates of conjoined twinning in parts of Southeast Asia and Africa.[10][13] These twins demonstrate a marked female predominance, with a female-to-male ratio of roughly 4:1, consistent with patterns observed in other conjoined twin subtypes.[14] Survival to live birth is low, with stillbirth rates for conjoined twins approaching 60%, influenced by the complexity of shared cranial vasculature and potential intrauterine complications.[1] The etiology of craniopagus twinning remains incompletely understood but is attributed to incomplete separation (fission) of a monozygotic embryo occurring around days 13 to 15 post-fertilization, leading to persistent cranial fusion.[1] Alternative theories propose secondary fusion of initially separate embryonic discs, though fission is more widely accepted.[1] No definitive genetic mutations or environmental exposures have been established as causal risk factors; maternal age, parity, and assisted reproductive technologies do not appear to increase susceptibility.[15][12] Speculative associations with consanguinity or familial patterns lack robust evidence, underscoring the sporadic nature of the condition.[12]Embryology and Pathophysiology
Developmental Origins
Craniopagus twins arise from the incomplete division of a monozygotic embryo, a process rooted in the fission theory of conjoined twin formation. In typical monozygotic twinning, a single fertilized ovum splits completely to form two distinct embryos, but conjoined twins result when this fission halts prematurely, leaving shared tissues. This incomplete separation occurs during the primitive streak stage of gastrulation, approximately 13 to 15 days after fertilization, when the embryonic disc is oriented along its craniocaudal axis. Failure to fully cleave the rostral (head) end of the disc leads to cranial fusion, distinguishing craniopagus from ventral fusions like thoracopagus.[16][17][18] The specific developmental anomaly in craniopagus involves the dorsal aspect of the embryonic disc, where the presumptive neural plate and overlying ectoderm remain fused. This results in shared calvarial bones, dural sinuses, and potentially cerebral vasculature or parenchyma, without involvement of lower body structures. Embryological models suggest that the degree of fusion—partial (limited to skin, skull, and dura) versus total (extending to deep venous or neural connections)—correlates with the timing and extent of fission arrest, with later splits yielding more superficial unions. No consistent genetic mutations have been identified, and cases appear sporadic, though vascular insufficiency or embryonic positioning may contribute to the localized cranial defect.[19][17] An alternative fusion theory, proposing secondary amalgamation of initially separate embryos, has been largely supplanted by fission evidence from monozygotic concordance and blastocyst studies, though it persists for certain parasitic variants. Craniopagus accounts for 2–6% of conjoined twin cases, with an overall incidence of about 1 per 2.5 million live births, underscoring its rarity and the precision required for complete embryonic separation.[11][16][11]Associated Physiological Challenges
Craniopagus twins encounter profound physiological challenges stemming from their fused cranial structures, which disrupt normal cerebral circulation, neural integrity, and overall homeostasis. The most critical issue involves shared dural venous sinuses, where venous drainage from one twin's brain may depend on the other's sagittal sinus, predisposing to catastrophic venous congestion, cerebral infarction, or intraoperative hemorrhage if compromised during development or intervention.[20] [21] This interdependence heightens mortality risk, as death of one twin can rapidly propagate multiorgan failure to the survivor via circulatory collapse.[22] Vascular anomalies extend to arterial shunting, where cerebral blood flow—constituting approximately 20% of cardiac output—may redirect between twins, inducing cardiac preload/afterload mismatches, hypotension, or strain on the conjoined circulatory system.[23] Such hemodynamic instability often manifests as asymmetric vital signs, oxygen desaturation, or twin-twin transfusion-like syndromes postnatally, exacerbating risks of ischemia or embolism. Neurological sequelae arise from brain compression, cortical interdigitation, or shared tissue, leading to distorted gyral patterns, hydrocephalus, seizures, or developmental impairments due to disrupted white matter tracts and leptomeningeal vasculature.[11] [16] Associated comorbidities compound these burdens, including cardiovascular malformations (e.g., ventricular septal defects), genitourinary anomalies, and craniofacial dysmorphisms that impair feeding, respiration, or thermoregulation.[16] Perinatal survival is low, with many succumbing to respiratory distress, infection, or acute decompensation from these interconnected failures, underscoring the causal primacy of vascular and neural fusion in driving multisystem vulnerability.[1]Anatomy of Conjoined Structures
Vascular and Dural Connections
Craniopagus twins exhibit variable vascular and dural connections depending on whether the fusion is classified as partial or total, with the latter defined by the presence of significant shared dural venous sinuses (SDVS).[10] In partial forms, vascular anastomoses are minimal, often limited to small leptomeningeal connections, while total forms show extensive sharing, particularly of venous structures, which complicates surgical separation due to risks of venous infarction or hemorrhage.[24][11] Arterial supply to the cerebral hemispheres is typically independent in both partial and total craniopagus, with each twin's major vessels arising from their respective carotid and vertebrobasilar systems.[24] However, cross-filling can occur, such as shared middle cerebral artery branches supplying portions of the contralateral twin's brain, as observed in some total angular fusions or specific cases via angiography.[10][25] Venous drainage poses the greatest challenge, with total craniopagus featuring shared dural venous sinuses that often form a circumferential venous sinus (CVS) replacing the superior sagittal sinus, draining homolateral hemispheres into common posterior structures.[10] This CVS is contained within a peripheral dural shelf, and interconnecting channels may distort drainage patterns, favoring one twin and increasing separation risks.[24][11] In partial forms, sinuses remain largely separate with only minor anastomoses.[24] Imaging modalities like MR venography and digital subtraction angiography are essential for mapping these, revealing shared lumens or crossover drainage.[25] Dural connections involve fusion at the junction site, often with a single-layered transverse dural septum or shelf separating the hemispheres in total forms, where the falx cerebri is absent or anomalous.[10] Defects in the dura are common, permitting cortical interdigitation or parenchymal bridges, particularly in total craniopagus, while partial forms may have an intact or minimally deficient dura with a bony septum.[24][25] These features contribute to brain compression and distortion in total cases, influencing preoperative planning.[11]Neural and Brain Tissue Sharing
In craniopagus twins, neural and brain tissue sharing manifests variably, often limited to superficial cortical parenchyma or bridging structures rather than extensive fusion of deep neural networks. Approximately 30% of cases involve shared or fused brain tissue, typically in occipital or parietal regions corresponding to the site of cranial union, with partial forms showing higher incidence of such involvement compared to total fusions.[11] Deep subcortical sharing, such as thalamic connections, is exceedingly rare and documented primarily in isolated case reports rather than as a general feature.[26] Among surviving neonates, shared brain tissue tends to be minimal, often confined to leptomeningeal or superficial cortical layers without significant interhemispheric neural integration, as extensive parenchymal fusion is embryologically incompatible with prolonged viability.[26] Preoperative imaging, including MRI, frequently reveals these adhesions as fused gyri or small cortical bridges, but functional neural interconnectivity—such as sensory crosstalk—remains unverified beyond anecdotal observations and lacks empirical confirmation in peer-reviewed studies of separated twins.[10] Dural defects overlying shared tissue exacerbate risks, as they permit aberrant neural bridging without clear vascular dominance.[25] The presence of shared neural tissue profoundly impacts prognosis and intervention feasibility, rendering complete surgical separation infeasible in most instances without catastrophic deficits, as transection disrupts irreplaceable cortical functions.[25] In staged separations, undetected parenchymal sharing identified intraoperatively has led to partial successes at the cost of hemiparesis or cognitive impairment in one twin, underscoring the causal primacy of tissue fusion over vascular factors in determining outcomes.[27] Conservative management is thus prioritized when neural sharing exceeds 10-20% of cortical volume, based on volumetric assessments from advanced neuroimaging.[28]Diagnosis and Assessment
Prenatal and Postnatal Imaging
Prenatal diagnosis of craniopagus twins typically begins with routine obstetric ultrasonography, which can identify fused crania as early as 19 weeks of gestation by revealing a single shared skull enclosing two distinct cerebral hemispheres.[29] This modality detects the absence of separation between fetal heads and may show associated anomalies such as shared vascular structures or abnormal lie, though limitations in soft tissue contrast necessitate confirmation with advanced techniques.[10] Fetal MRI, performed after ultrasound suspicion, provides high-resolution multiplanar images of brain parenchyma, dural sinuses, and potential neural tissue interdigitation without exposing the fetus to ionizing radiation, enabling assessment of fusion type (e.g., partial versus complete) and prognosis for viability.[10] In cases of suspected craniopagus, MRI sequences such as T2-weighted imaging highlight cerebrospinal fluid spaces and cortical gyri fusion, correlating with postnatal findings and informing parental counseling on separation feasibility.[30] Postnatally, a multimodality imaging protocol is essential for surgical planning, starting with non-contrast CT to evaluate bony fusion extent and intracranial calcifications.[24] CT angiography, often combined with venography via sequential intravenous contrast administration, maps arterial and venous connections, identifying critical shared vessels such as dural sinuses or carotid arteries that could preclude separation if vital to both twins' perfusion.[16] Perfusion CT variants further delineate inter-twin brain blood supply dependencies, revealing areas where one twin's vasculature sustains the other's cerebral tissue, a factor in 40-60% of reported craniopagus cases.[31] MRI, with its superior soft tissue resolution, assesses neural continuity, including fused cortical regions or bridging veins, using sequences like diffusion tensor imaging for white matter tractography to quantify shared parenchyma volume.[31] Conventional digital subtraction angiography may supplement these for dynamic vascular evaluation, particularly in complex fusions involving the torcular herophili.[32] This integrated approach, tailored to fusion subtype, minimizes risks during multidisciplinary evaluation and has evolved to incorporate 3D reconstructions for precise preoperative simulation.[24]Preoperative Evaluation Protocols
Preoperative evaluation of craniopagus twins requires a multidisciplinary approach involving neurosurgeons, neuroradiologists, interventional radiologists, anesthesiologists, and plastic surgeons to assess separation feasibility, map shared structures, and mitigate risks such as venous thrombosis or cerebral infarction.[10] This process typically begins after postnatal stabilization and includes detailed anatomical classification using systems like Stone and Goodrich, distinguishing partial fusions (independent calvaria except at junction) from total vertical or angular types (continuous cranium with shared dural venous sinuses).[10] Timing is critical, with separations ideally planned between 9 and 12 months of age for total vertical craniopagus to optimize psychomotor development while minimizing brain fusion progression beyond 30%, which correlates with high morbidity.[10] Imaging forms the cornerstone, employing multiparametric protocols to delineate vascular, neural, and skeletal connections. High-resolution CT with 3D reconstructions evaluates skull fusion extent and bone stock, often using sequential contrast injections (2 mL/kg per twin) for CT angiography and venography to identify shared arterial or venous systems.[24] Complementary MRI sequences, including 3D T1- and T2-weighted imaging, diffusion tensor imaging for white matter tracts, and time-resolved MR angiography/venography, assess brain parenchyma interdigitation, dural defects, and eloquent area involvement.[10] [24] Vascular mapping prioritizes shared dural venous sinuses (e.g., superior sagittal) and cortical venous anastomoses, with digital subtraction angiography confirming flow dynamics and enabling balloon occlusion tests to predict tolerance of ligation.[10] Staged endovascular embolization of select veins may precede surgery to promote collateral drainage, particularly in total fusions where one twin's venous outflow depends on the other.[10] Neural evaluations via tractography detect crossed fibers or fused cortex, informing surgical planes, while 3D printing and virtual reality models from integrated imaging aid in simulating craniotomies and reconstructions.[24] Additional assessments address comorbidities, such as echocardiography for cardiac anomalies and EEG for synchronized activity indicating functional sharing, though primary focus remains on neuroimaging to determine single- versus multi-stage separation viability.[10] Risks like circulatory interdependence necessitate careful sedation protocols during imaging to avoid hemodynamic instability from head positioning or contrast effects.[10] This comprehensive protocol, refined through experiences with multiple twin sets, enhances precision but underscores that extensive sharing (>30% brain fusion) often precludes safe separation without substantial neurological deficits.[24] [10]Treatment Options
Conservative Management
Conservative management of craniopagus twins involves supportive and palliative care without attempting surgical separation, typically pursued when extensive shared vascular, dural, or neural structures render separation prohibitively risky, with mortality rates exceeding 25% in operative cases.[20] This approach prioritizes symptom alleviation and quality-of-life maintenance through multidisciplinary interventions, including neonatal intensive care for respiratory and circulatory support, ventriculoperitoneal shunts to address hydrocephalus, nutritional optimization via enteral feeding, and infection prophylaxis with antibiotics.[1] Physical therapy and orthopedic monitoring help mitigate mobility limitations from the conjoined cranium, while regular neuroimaging tracks progressive complications like venous thrombosis or cerebral edema.[33] Outcomes under conservative management remain guarded, with perinatal survival limited by inherent physiological strains; approximately 40% of craniopagus twins are stillborn, and one-third succumb within 24 hours postpartum due to circulatory overload or organ failure.[11] Among those surviving infancy, long-term morbidity predominates, encompassing developmental delays, recurrent seizures, and skeletal deformities, though cognitive and social milestones can progress adequately in select cases.[33] A documented eleven-year follow-up of twins whose separation was aborted at 41 months due to hemodynamic instability revealed intact social and cognitive development alongside persistent physical hurdles, such as spinal subluxation from trauma leading to partial cord ischemia.[33] Such instances underscore conservative care's potential to avert immediate operative lethality, albeit without resolving core anatomical interdependencies that curtail lifespan and independence.[34] Specialized centers with pediatric subspecialties are essential for optimizing these trajectories, emphasizing ethical focus on holistic welfare over curative intent.[1]Surgical Separation Techniques
Surgical separation of craniopagus twins requires a multidisciplinary approach involving neurosurgeons, plastic surgeons, interventional radiologists, and anesthesiologists, often conducted in multiple stages to manage shared vascular, dural, and skeletal structures while minimizing neurological deficits.[20] Multi-staged procedures have demonstrated lower mortality rates compared to single-stage separations, particularly for total craniopagus presentations, by allowing gradual adaptation to hemodynamic changes and tissue expansion.[11] Initial stages typically focus on skeletal disarticulation and soft-tissue preparation. A strip craniectomy disconnects fused skull segments, followed by distraction osteogenesis using custom external devices to gradually separate the crania at rates of approximately 2 mm per day over several weeks, reducing intracranial pressure and facilitating subsequent access.[20] Concurrently, circumferential soft-tissue constriction and subcutaneous tissue expanders are employed to generate adequate scalp coverage, expanding over months to accommodate closure after separation; for instance, shared scalp circumference may be reduced from 40 cm to 28 cm prior to final intervention.[20] These steps address the high fusion rates in calvarial bones observed in most cases.[7] The definitive separation stage targets vascular and dural connections, guided by preoperative angiography and intraoperative navigation. Shared superior sagittal sinuses and bridging veins are sequentially ligated or embolized, prioritizing preservation of dominant drainage patterns—often assigning the larger sinus to the twin with greater cerebral volume—while monitoring intracranial pressure and cerebral perfusion.[35][20] Dural partitions are incised along the midsagittal plane, with minimal brain parenchymal resection if fusion exists, leveraging pediatric neuroplasticity; computer-aided design (CAD), 3D modeling, and virtual surgical planning enable precise mapping of these structures to avoid ischemia.[20] Post-separation, skull reconstruction uses autologous bone grafts or synthetic implants, combined with skin grafting for wound closure.[8] For craniopagus parasiticus, where one twin is rudimentary and acardiac, techniques simplify to excision of the parasitic mass following vascular ligation, often in a single stage shortly after birth, as the autosite retains independent circulation; successful cases report survival without major deficits in the viable twin.[36] Overall success, defined as both twins surviving 30 days post-surgery, favors vertical unions (p < 0.001) and operations before 12 months of age, with multi-stage approaches trending toward improved outcomes amid 25-50% mortality rates across reported series.[7][9]Multidisciplinary Team Involvement
The separation of craniopagus twins requires a coordinated multidisciplinary team to navigate the intricate shared cranial vasculature, dural sinuses, and potential neural connections, often involving staged procedures over months with risks of up to 50% mortality per stage in complex cases.[20] This approach integrates preoperative planning via 3D modeling, simulations, and imaging to optimize outcomes, as demonstrated in successful separations at institutions like Children's Hospital of Philadelphia.[20] [37] Neurosurgeons form the core of the surgical team, directing the dissection of fused brain tissue, division of shared venous structures like the superior sagittal sinus, and intraoperative navigation to preserve viable parenchyma in each twin.[20] [38] Plastic surgeons collaborate closely for scalp flap elevation, tissue expansion with allografts or autografts, and cranial reconstruction using custom implants to achieve durable coverage and cosmesis.[20] [38] Pediatric anesthesiologists manage the unique challenges of dual-patient anesthesia, including synchronized hemodynamic monitoring, blood conservation strategies, and differential drug administration to minimize cross-circulation effects during procedures lasting up to 20 hours.[37] [38] Interventional neuroradiologists contribute through preoperative balloon occlusion tests and embolization of bridging veins to reduce intraoperative hemorrhage, guided by digital subtraction angiography and MRI venography.[38] Postoperative care falls to neonatal or pediatric intensivists, who oversee ventilation, seizure prophylaxis, and infection control in the ICU, often requiring prolonged mechanical support and multidisciplinary rounds for complications like cerebrospinal fluid leaks or hydrocephalus.[20] [37] Specialized nurses, perfusionists for potential hypothermic circulatory arrest, and technicians provide logistical support, including dual operating room setups and blood product readiness to handle transfusion volumes exceeding 100 mL/kg per twin.[37] This integrated effort has enabled survival rates improving from near-zero historically to over 50% in select modern cases with total-fusion anatomy.[20]Historical Developments
Early Case Reports and Attempts
The earliest documented case of craniopagus twins occurred in 1491 near Worms, Germany, where a pair born in Bavaria was described in contemporary accounts as "Ein monstrum" (a monster), with an accompanying woodcut illustration appearing around 1496.[23][39] These twins, joined at the cranium, survived briefly before postmortem examination, reflecting the era's tendency to classify such births as portents or anomalies rather than subjects for medical intervention.[23] In 1495, another report detailed female craniopagus twins conjoined at the foreheads in Brisant near Worms; following the death of one twin at approximately age 10, a rudimentary separation attempt involved incising the soft tissue bridge, but the surviving twin died shortly thereafter from hemorrhage and infection.[40][41] This event, recorded in early natural history texts, represents the first noted surgical effort at separation, though limited by primitive techniques and lack of vascular understanding, resulting in inevitable failure.[40] Subsequent early modern reports, spanning the 16th to 19th centuries, primarily involved postmortem dissections or descriptive accounts in medical literature, such as those in Sebastian Münster's Cosmographia universalis (1544), which cataloged cranial unions without viable interventions due to high perinatal mortality and ethical prohibitions against operating on live subjects.[26] The first modern surgical attempt occurred in 1928, when A. P. Cameron endeavored to separate infant craniopagus twins, but both succumbed intraoperatively to uncontrollable bleeding, underscoring the profound vascular interdependencies.[42] Pioneering mid-20th-century efforts marked initial progress: in 1952–1953, Oscar Sugar staged the separation of brothers Roger and Rodney Brodie, with Roger surviving long-term after the sacrifice of Rodney, who shared critical dural venous sinuses.[23] This was followed in 1956 by Maitland Baldwin's separation of Teresa and Virginia Bunton at the National Institutes of Health, where both initially survived, though Teresa died in 2017 from unrelated causes.[43] These cases highlighted the necessity of preoperative angiography and staged procedures but yielded survival rates below 50%, often at the cost of one twin.[40]Advancements in Surgical Methods
Surgical separations of craniopagus twins transitioned from high-mortality single-stage procedures in the mid-20th century to more viable multistage approaches. The earliest documented successful operation occurred on December 11, 1956, when Dr. Maitland Baldwin separated twins at the National Institutes of Health, marking a shift from prior fatal attempts dating back to 1928.[43] A 1957 procedure by Voris et al. achieved the first long-term survival of both twins post-separation, though early single-stage surgeries often resulted in one or both deaths due to massive intraoperative blood loss or cardiac arrest.[20] By the late 20th century, staged separations emerged as a key innovation, involving progressive disconnection of shared venous sinuses and brain tissue across multiple operations to mitigate risks associated with complex vascular anastomoses.[39] Of 62 documented attempts over a century, 28 employed multistage techniques, contrasting with 34 single-stage efforts, and contributed to improved outcomes when performed before age 1-2 years.[44] Neurosurgeon James T. Goodrich pioneered refinements in these multistage methods, completing 7 separations by 2020, drawing on historical precedents to enhance precision in pediatric neurosurgery.[45] Preoperative advancements in neuroimaging, including 3D CT, MRI, and MR venography, have enabled detailed assessment of shared dural venous systems and parenchymal connections, facilitating safer planning.[8] Neuroendovascular interventions, such as preoperative embolization of dominant venous drainage, further reduce hemorrhage risks during final separation stages.[46] Recent integrations of 3D printing for anatomical replicas, virtual surgical planning, and neuronavigation have optimized tissue expansion, skull reconstruction, and intraoperative guidance, as seen in four-stage separations like that of Sudanese twins Rital and Ritaj in 2011 at Great Ormond Street Hospital.[8] These developments correlate with rising success rates, with both twins surviving over 30 days in 65.6% of the 32 attempts in the past two decades, compared to 40% historically.[44]Notable Cases
Successfully Separated Pairs
One of the earliest successful separations of craniopagus twins was performed on December 11, 1956, at the National Institutes of Health by Dr. Maitland Baldwin, marking a pioneering effort in the field despite the high risks involved.[43] Subsequent reports, such as the 1957 case by Voris et al., confirmed long-term survival for both twins post-separation, establishing a benchmark for future interventions.[20] Over the decades, survival rates have improved with multidisciplinary approaches, including preoperative imaging, vascular staging, and reconstructive techniques, though successful outcomes remain rare, with vertical craniopagus presentations showing the highest feasibility.[7]| Twins' Names | Birth Date | Separation Date | Location | Key Details |
|---|---|---|---|---|
| Erin and Abby Delaney | November 24, 2016 | June 6-17, 2017 (multi-stage) | Children's Hospital of Philadelphia (CHOP), USA | 10-month-old girls joined at the back of the head; surgery involved 43 specialists, dural separation, and skull reconstruction; both survived with neurological deficits managed post-op.[47] |
| Safa and Marwa Kanaan | 2016 | February 2019 (multi-stage) | Great Ormond Street Hospital (GOSH), UK | Partial vertical craniopagus; four surgeries over months included venous reconstruction and tissue expansion; both achieved independent milestones like sitting and walking by age 2.[48] |
| Abigail and Micaela Bachinskiy | December 2019 | October 24-25, 2020 | UC Davis Children's Hospital, USA | 9-month-old girls with shared venous drainage; 3D modeling and mixed-reality planning aided the 20+ hour procedure; both recovered, with one discharged after 3 months.[49] [50] |
| Amari and Javar Ruffin | February 2023 | July-August 2024 (multi-stage) | Children's Hospital of Philadelphia (CHOP), USA | Boys joined at the top of heads; series of operations addressed shared vasculature; marked CHOP's 32nd conjoined twin separation, with both stabilizing post-procedure.[51] |