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David Perlmutter

David Perlmutter, M.D., FACN, is a board-certified neurologist, Fellow of the American College of , and six-time New York Times bestselling author renowned for elucidating the causal links between dietary factors—particularly refined carbohydrates and disruptions to the gut microbiome—and neurological disorders such as , , and . He earned his medical degree from the School of Medicine, where he was awarded the Leonard G. Rowntree Research Award for research excellence, and completed postgraduate training to become board-certified in . As an Associate Professor at the Miller School of Medicine and editorial board member for the Journal of Alzheimer’s Disease, Perlmutter has authored numerous peer-reviewed publications in outlets including Archives of Neurology and Neurosurgery, focusing on metabolic influences on brain function. His breakthrough book, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar—Your Brain's Silent Killers (2013), posits that and high-glycemic foods drive and neurodegeneration via and , selling over one million copies, topping the New York Times bestseller list, and appearing in 32 languages. Subsequent works like Brain Maker (2015), which details the gut microbiome's role in modulating brain health through microbial diversity and short-chain fatty acid production, and Drop Acid (2022), linking elevated uric acid to metabolic dysfunction, have similarly achieved bestseller status and informed public discourse on preventive nutrition. Perlmutter's advocacy for ketogenic-style diets, probiotic interventions, and avoidance of processed foods has earned accolades including the Linus Pauling Award and Humanitarian of the Year from the American College of Nutrition, though it has drawn criticism from skeptics who contend his interpretations selectively emphasize associative data over randomized controlled trials, labeling aspects as overstated or pseudoscientific. Despite such pushback, longitudinal studies since Grain Brain's publication have corroborated associations between high-carbohydrate intake, , and cognitive decline, aligning with Perlmutter's emphasis on causal metabolic pathways over symptomatic treatments.

Biography

Early Life and Education

David Perlmutter was born on December 31, 1954, in . Public records provide limited details on his childhood or family background, with no verifiable evidence of specific influences shaping early interests in health or . Perlmutter completed a in from in 1976. He then earned his (M.D.) from the University of Miami School of Medicine in 1981, during which he received the Leonard G. Rowntree Research Award for the best research project by a graduating senior medical student. Following , Perlmutter pursued postgraduate training, including a residency in at the , leading to in by the American Board of and . He later became a fellow of the American College of Nutrition, reflecting advanced standing in relevant to his neurological focus.

Personal Life

Perlmutter has maintained a long-term residence and private medical practice in , where he has lived and worked for over three decades. He has been married to Leize Perlmutter since approximately 1987, and the couple has two children: one pursuing a career in and the other training as a . Perlmutter's emphasizes clean-living practices, including growing their own , aligned with his personal adherence to low-carbohydrate dietary principles. In terms of community involvement, Perlmutter has supported charitable efforts focused on health and education, including contributions to Hope for Haiti, an organization providing medical care, schooling, and community development in underserved regions.

Professional Career

Clinical Practice and Specialization

David Perlmutter, a board-certified neurologist, established the Perlmutter Health Center in Naples, Florida, in 1998, focusing on integrative approaches to patient care for neurological conditions. His practice, located at addresses including 2205 Beacon Lane and 800 Goodlette Road North, emphasizes preventive and functional medicine strategies tailored to individual patients with neurodegenerative disorders, such as Alzheimer's disease. In clinical settings, Perlmutter incorporates nutritional interventions as core components of treatment protocols for patients exhibiting neurological symptoms, drawing on principles of holistic and preventive medicine to address underlying lifestyle factors. These approaches include dietary modifications, such as gluten-free regimens and reduced carbohydrate intake, applied to mitigate and support brain health in practice. He holds fellowships in the American College of Nutrition (FACN) and certification from the American Board of Integrative Holistic Medicine (ABIHM), which inform his patient-centered methodologies. Perlmutter serves on scientific advisory boards, including for Advanced Brain Technologies, where his expertise guides integrative neurological applications. His affiliations extend to the Institute for , reinforcing his specialization in bridging conventional with evidence-based nutritional and lifestyle interventions for chronic brain-related conditions.

Publications and Authorship

David Perlmutter has authored or co-authored multiple books focusing on the intersections of , metabolism, and neurological function, with several achieving commercial success as New York Times bestsellers. His works, published in 32 languages, include five titles that reached the , underscoring their broad dissemination within popular health literature. Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar—Your Brain's Silent Killers, released in September 2013, critiques the consumption of grains, refined carbohydrates, and sugars, positing their role in promoting and cognitive decline; it includes a 4-week dietary plan emphasizing higher fat intake. The book debuted at #1 on the New York Times nonfiction . Subsequent publications expanded these dietary themes. Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain—for Life, published on April 28, 2015, shifts emphasis to the gut microbiome's influence on brain health, advocating probiotic-rich interventions to modulate microbial composition for neurological benefits; it also became a New York Times bestseller. Related companion volumes, such as The Grain Brain Cookbook (2014) and The Grain Brain Whole Life Plan (2016), provide recipes and lifestyle protocols aligned with low-carbohydrate principles, both attaining New York Times bestseller status. Later works incorporate co-authorships and broader metabolic factors. Brain Wash: Detox Your Mind for Clearer Thinking, Deeper Relationships, and Lasting , co-authored with his son Austin Perlmutter and released in January 2020, addresses environmental and lifestyle influences on brain function alongside nutritional strategies; it ranked on the New York Times list. Drop Acid: The Surprising New Science of and How It Can Change Your Life for the Better, published February 15, 2022, examines elevated levels in relation to metabolic disorders, proposing a "LUV" (Lower Uric Values) dietary approach with recipes and assessments. Earlier, Perlmutter co-authored The Better Brain Book with Carol Colman in 2004, targeting preventive measures against age-related cognitive issues through lifestyle modifications. Across his bibliography, Perlmutter's themes evolve from initial scrutiny of carbohydrate sources in Grain toward integrated views incorporating microbial ecology and metabolic markers like , consistently promoting dietary shifts to support resilience.

Media Appearances and Advocacy

Perlmutter has appeared multiple times on , including a 2013 segment promoting his book Grain Brain and discussing dietary impacts on neurological conditions. He has served as a medical advisor to the program and featured in episodes addressing topics like eating disorders and glutathione's role in . Additional television exposure includes national outlets such as Today, , and , where he has addressed findings from his publications on . Beyond television, Perlmutter hosts The Empowering Neurologist , featuring interviews with health experts on topics including and wellness interventions. He has guested on other s, such as Lewis Howes' program in 2022 discussing diet's influence on behavior and disease risk, and the A4M's Redefining Medicine in 2017 and 2021, covering neurological applications of nutrition. These platforms have amplified his promotion of low-carbohydrate dietary strategies for cognitive maintenance. Perlmutter lectures frequently at professional conferences and symposia sponsored by organizations including , Scripps Institute, the , and IMF, focusing on nutritional influences on brain function. Recent engagements include a online discussion evaluating the sustained applicability of Grain Brain's principles amid evolving ketogenic trends, and scheduled 2025 appearances at the A4M event in (December 13–15) and Eudemonia in West Palm Beach (November 13–16). In advocacy efforts, Perlmutter has critiqued USDA nutritional frameworks, arguing that the food pyramid—foundational to —prioritizes grains and over 50% of calories from carbohydrates, potentially compromising neurological outcomes, and called for emphasis on fats and reduced grain intake. These positions, disseminated through media and events, seek to influence public and policy discourse on dietary recommendations for brain health.

Core Theories and Contributions

Nutritional Impacts on Neurological Health

Perlmutter posits that excessive consumption of carbohydrates, particularly grains and sugars, elevates blood glucose levels, fostering in brain tissue—a phenomenon he describes as a key driver of and , ultimately contributing to disorders such as . In his 2013 book Grain Brain, he argues that this metabolic disruption impairs neuronal energy metabolism, leading to of proteins, which initiates cascades of and free radical damage; he supports this with references to animal models showing high-sugar diets increasing plaque deposition, a hallmark of Alzheimer's . Perlmutter emphasizes that even prediabetic blood sugar elevations, rather than overt , correlate with accelerated atrophy, drawing on data indicating smaller hippocampal volumes in individuals with higher fasting glucose. Empirical biomarkers underscore his causal framework: longitudinal data from the English of demonstrate that elevated HbA1c levels—reflecting average glucose over preceding months—predict steeper cognitive decline over a decade, independent of status. Perlmutter interprets these findings as that chronic directly compromises brain resilience, citing mechanisms like reduced cerebral glucose utilization and heightened vulnerability to , which he contrasts with ancestral low-carb dietary patterns that presumably minimized such risks. He further links gluten-containing grains to intestinal permeability, exacerbating that crosses the -brain barrier, though he prioritizes carbohydrate-induced insulin dysregulation as the proximal neurological threat. To mitigate these effects, Perlmutter advocates ketogenic or low-carbohydrate diets rich in healthy fats, which he claims shift brain fuel toward ketones, bypassing glucose-dependent impairments and bolstering mitochondrial function to curb oxidative damage. Clinical observations from his practice, detailed in Grain Brain, report cognitive reversals in patients adopting such regimens—reducing carbs below 60 grams daily while increasing fat intake—which align with studies he references showing improved and in low-glycemic states. This approach, Perlmutter contends, not only stabilizes blood sugar but enhances , with verifiable outcomes like normalized HbA1c tracking alongside gains, positioning dietary restriction as a preventive strategy grounded in metabolic causality over symptomatic .

Gut Microbiome and Brain Function

In his 2015 book Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain—for Life, David Perlmutter asserts that the gut exerts a profound influence on function via the gut-brain axis, where microbial communities modulate neurotransmitter synthesis—such as serotonin and gamma-aminobutyric acid (GABA)—and regulate , with signaling primarily transmitted through the . He contends that , characterized by reduced microbial diversity, disrupts these pathways, potentially initiating neurological dysfunction before overt pathology manifests, as evidenced by observational data linking early-life microbiome alterations to later cognitive and behavioral impairments. Perlmutter specifically implicates antibiotic overuse in promoting dysbiosis by decimating beneficial bacteria, which he correlates with heightened risks for conditions like autism spectrum disorder and ; for instance, he references human studies showing antibiotic exposure in infancy associates with altered gut flora and subsequent neurodevelopmental issues. Animal models cited in his work demonstrate how depletion via antibiotics leads to anxiety-like behaviors and impaired , mediated by vagal and immune signaling, underscoring a directional from gut disruption to alterations rather than mere . To counteract and support health, Perlmutter recommends incorporating —prioritizing strains like and at doses of 10 to 50 billion colony-forming units daily—and prebiotics such as , onions, and dandelion greens to nourish beneficial microbes, alongside minimizing processed foods that foster pathogenic overgrowth. He draws on observational cohorts and experiments indicating that such interventions enhance microbial diversity, reduce gut-derived , and improve balance, thereby preempting pharmaceutical interventions focused on symptom management. This approach positions restoration as a foundational strategy for mitigating vulnerabilities, distinct from symptomatic treatments.

Critique of Mainstream Dietary Guidelines

Perlmutter contends that mainstream dietary guidelines, exemplified by the 1992 USDA Food Pyramid recommending 6-11 daily servings of grains as the foundational food group, promote carbohydrate-heavy eating patterns that overlook causal mechanisms linking refined and even whole grains to and . He characterizes this structure as fundamentally inverted, prioritizing metabolically disruptive carbs over fats and proteins, and argues it stems from reliance on associative epidemiological studies rather than controlled metabolic data showing postprandial glucose spikes drive and lipid dysregulation. Recent iterations, such as the 2020-2025 Dietary Guidelines endorsing over 50% of calories from carbohydrates including , perpetuate this one-size-fits-all approach despite individual metabolic variances. This paradigm shift traces to the 1977 Dietary Goals for the , which advised cutting fats to under 30% of calories while boosting complex carbohydrates, influencing subsequent policy and correlating with a 29% increase in per capita grain consumption from 1970 onward. Adult rates, stable at around 15% in 1970, surged to nearly 40% by 2016, with the onset dated to 1976-1980 amid rising processed carb availability and reduced intake. Perlmutter attributes these trends partly to lobbying shaping guidelines toward surplus grain promotion, normalizing high-glycemic diets that exacerbate and contribute to intertwined epidemics of , , and associated conditions like neurodegeneration, rather than isolated caloric excess. Perlmutter advocates carbohydrate restriction to low-glycemic thresholds, customized via genetic markers such as the APOE4 allele, which amplifies carb-related risks through impaired lipid handling and heightened . Randomized trials affirm low-carbohydrate diets' superiority in reversing hallmarks, yielding greater reductions in triglycerides, , waist circumference, and compared to low-fat, high-carb regimens. While guidelines cite observational links between whole grains and lower cardiovascular risk, Perlmutter prioritizes intervention evidence, including metabolic chamber studies, revealing carbs' direct glycemic impact over correlative fiber benefits, urging reevaluation unbound by entrenched nutritional dogma.

Reception and Controversies

Scientific Achievements and Empirical Support

Perlmutter, a board-certified neurologist and Fellow of the American College of Nutrition, has published articles in peer-reviewed journals including Archives of Neurology, Neurosurgery, and Journal of Applied Nutrition. These contributions include discussions on inflammatory processes in neurological conditions and nutritional interventions for brain health. He also serves on the editorial board of the Journal of Alzheimer's Disease, influencing peer discourse on neurodegeneration. In clinical practice, Perlmutter's application of dietary modifications, particularly low-carbohydrate and ketogenic protocols, aligns with established for managing certain neurological disorders. For instance, ketogenic diets have been shown to reduce frequency in refractory patients, with randomized controlled trials demonstrating up to 50% reduction in adults following high-fat, low-carb regimens that induce and enhance mitochondrial function in neurons. This metabolic shift, which Perlmutter extends to broader neurodegeneration, is supported by preclinical data indicating via reduced and improved energy substrate utilization in brain tissue. Perlmutter's framework emphasizing gut microbiome modulation for brain health draws partial empirical backing from studies linking to , such as those showing short-chain fatty acid production from prebiotic fibers influences blood-brain barrier integrity and levels in animal models of . While direct clinical trials from his practice are not peer-documented, his protocols mirror interventions in where dietary shifts have correlated with symptom improvements in inflammatory conditions, including reported enhancements in cognitive metrics via flavanol-rich interventions that boost cerebral blood flow. His work has garnered recognition within , including the 2002 Linus Pauling Award for contributions to functional , reflecting integration of nutritional biochemistry into neurological care. Empirical alignments persist in cohort studies associating high dietary sugar intake with elevated risk, particularly in genetically susceptible individuals, underscoring Perlmutter's cautions against carbohydrate excess.

Criticisms and Scientific Debates

Critics have accused Perlmutter's Grain Brain (2013) of promoting pseudoscientific claims by overstating the causal link between grain consumption and neurodegenerative diseases like , relying on selective evidence rather than comprehensive meta-analyses that often show whole grains associated with reduced risk. For instance, reviews highlight that Perlmutter extrapolates from observational data on and to indict all carbohydrates, while ignoring randomized controlled trials (RCTs) demonstrating no direct causation between grains and brain atrophy, and critiquing his dismissal of protective dietary patterns like the that include moderate grains. Debates intensify around Perlmutter's assertions of widespread gluten sensitivity beyond celiac disease, with mainstream and contending that (NCGS) lacks robust causal evidence tying symptoms primarily to proteins, as double-blind trials frequently attribute gastrointestinal distress to fermentable oligosaccharides (FODMAPs) or effects rather than gluten itself.01533-8/fulltext) A 2025 in analyzed controlled challenges and concluded that while self-reported NCGS symptoms are real, gluten's role is minimal in most cases, challenging Perlmutter's broader inflammation hypothesis as an overextrapolation from celiac-specific without sufficient population-level RCTs confirming neurological harm in non-celiac individuals.01533-8/fulltext) Neurologists further note that epidemiological data fail to establish grains as a primary driver of Alzheimer's incidence, emphasizing genetic and vascular factors over dietary carbs in the absence of long-term interventional trials. Perlmutter has rebutted these critiques by emphasizing mechanistic evidence of carbohydrate-induced hyperglycemia and gut dysbiosis contributing to neuroinflammation, arguing that the rise in metabolic disorders—from 10.8% U.S. diabetes prevalence in 2013 to 14.7% by —corroborates his warnings even amid limited RCTs, which he attributes to funding biases favoring established guidelines. He advocates for personalized low-carb interventions supported by emerging studies showing cognitive improvements in at-risk populations, while calling for prospective trials to test directly, maintaining that with rising neurodegeneration rates underscores the hypothesis's plausibility pending definitive data.

Public Influence and Cultural Impact

Perlmutter's book Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar—Your Brain's Silent Killers, published in 2013, achieved #1 New York Times bestseller status and topped lists including those from and , selling widely and contributing to heightened public interest in reducing carbohydrate intake and avoiding . This success aligned with and amplified broader low-carb and gluten-free dietary shifts, as ideas once viewed as fringe—such as prioritizing fats over grains—gained traction among consumers seeking alternatives to conventional high-carbohydrate recommendations. Despite dismissal by some mainstream outlets, these trends manifested in increased market demand for gluten-free products and low-carb protocols, influencing everyday health behaviors independent of institutional endorsement. Media coverage has often framed Perlmutter's advocacy as promoting , with critics labeling his carbohydrate critiques as unsubstantiated or , particularly in outlets questioning the shift away from grain-inclusive diets. Such portrayals contrast with perspectives emphasizing personal dietary , as Perlmutter's work has fueled debates challenging government-issued guidelines that prioritize whole grains, advocating instead for individual experimentation with food choices to influence health outcomes like . This tension highlights a , where left-leaning critiques prioritize views, while his influence resonates in discussions favoring self-directed over standardized policies. Perlmutter's emphasis on dietary interventions has empowered patients to question pharmaceutical-heavy approaches to neurological issues, as evidenced by his podcast The Empowering Neurologist, which features discussions on modifications for conditions like Alzheimer's, drawing listener engagement through narratives of reversal via . Followers report adopting his protocols for cognitive preservation, fostering toward interventionist models and promoting proactive, food-based agency in health management. This has extended to policy dialogues, where his views underscore the societal costs of processed carb reliance, urging a reevaluation of narratives centered on drugs over modifiable behaviors.

Recognition

Professional Awards

In 2002, Perlmutter received the Award from the Institute for , recognizing his pioneering clinical applications of diet and nutrition in addressing brain-related disorders. That same year, he was awarded the Denham Harman Award by the American College for Advancement in Medicine for advancing the understanding of oxidative stress's role in neurological diseases through free radical science applied to patient care. In 2006, the National Nutritional Foods Association selected Perlmutter as Clinician of the Year, honoring his integrative approaches to nutritional interventions in clinical . These awards highlight peer recognition within functional and nutritional communities for his evidence-based innovations in treating neurological conditions via modifiable factors.

Honors and Fellowships

Perlmutter is a of the American College of Nutrition (FACN), a designation acknowledging expertise in and its applications to . He also holds certification through the American Board of Integrative Holistic Medicine (ABIHM), reflecting peer-recognized proficiency in integrative medical practices that bridge conventional and holistic approaches. These fellowships underscore institutional validation of his work linking nutrition to neurological outcomes, distinct from general in . Perlmutter serves on the Board of Directors of the American College of Nutrition, contributing to its governance and strategic direction in advancing nutritional research and education. He is additionally a distinguished fellow and Scientific Advisory Board member of the American Nutrition Association, roles that involve guiding policy and research priorities in . In 2010, the American College of Nutrition honored him with its Humanitarian of the Year award for contributions to public education on preventive health strategies, particularly through outreach on dietary influences on chronic disease. These positions highlight sustained peer acknowledgment within organizations focused on functional and nutritional paradigms, rather than one-time accolades.

References

  1. [1]
    About - David Perlmutter M.D.
    David Perlmutter, MD, FACN is a board-certified neurologist, Fellow of the American College of Nutrition, and five-time New York Times bestselling author.
  2. [2]
    Neurologist & five-time New York Times bestselling ... - Dr. Perlmutter
    He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award.Missing: biography | Show results with:biography
  3. [3]
    David Perlmutter, MD: The Dynamic Brain - PMC - NIH
    He received his MD degree from the University of Miami School of Medicine, where he was awarded the Leonard G. Rowntree Research Award.Missing: biography | Show results with:biography
  4. [4]
    Charlatans like Dr. Oz and Dr. “Grain Brain” Perlmutter are giving ...
    Jun 24, 2015 · In the piece, Alan Levinovitz goes through the flimsy evidence behind Perlmutter's ideas about the evils of gluten and grains, and all the other ...
  5. [5]
    The Problem With David Perlmutter, the <i>Grain Brain</i> Doctor
    Jun 24, 2015 · The basic premise of Grain Brain doesn't fit with the current neurological literature: The latest reviews of evidence-based dietary approaches ...
  6. [6]
    Has Grain Brain Stood the Test of Time? - David Perlmutter M.D.
    Oct 31, 2024 · Perlmutter's View in 2013: He warned against the consumption of refined carbohydrates and processed foods, linking them to poor brain health and ...
  7. [7]
    [PDF] CURRICULUM VITAE DAVID PERLMUTTER, M.D., F.A.C.N. ...
    Jan 25, 2023 · DAVID PERLMUTTER, M.D., F.A.C.N.. PERSONAL. Date and Place of Birth. December 31, 1954. Coral Gables, FL. Married, two children. EDUCATION.
  8. [8]
    20 Questions: David Perlmutter, MD, FACN, ABIHM - Neurologist
    Feb 25, 2016 · Perlmutter received a degree in biology from Lafayette College (1976) and a Doctor of Medicine from University of Miami School of Medicine (1981) ...<|separator|>
  9. [9]
    David Perlmutter, MD, FACN, ABIHM - Advanced Brain Technologies
    He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award for best research by a ...
  10. [10]
    The Role of Microbiome Diversity in Brain Health and Inflammation
    David Perlmutter, MD, FACN, ABIHM, is in private practice in Naples,. Florida, and is an associate professor at the University of Miami School of. Medicine in ...
  11. [11]
    At Home with Grain Brain Author Dr. David Perlmutter | Naples ...
    Apr 1, 2015 · He and Leize have been married for 28 years, and have two children, an artist and a young doctor. The doctor has received some pushback in ...Missing: family | Show results with:family
  12. [12]
    Lady in Blue - Gulfshore Life
    Jul 1, 2022 · Her family grew their own food as part of a clean-living lifestyle prioritized by her father, the well-known nutritionist, Dr. David Perlmutter.<|separator|>
  13. [13]
    David Perlmutter '76 is Recognized Internationally as Leader in ...
    May 21, 2010 · -based Perlmutter Health Center, had been supporting the charitable organization Hope for Haiti, which provides education, health care, and ...Missing: involvement | Show results with:involvement
  14. [14]
    Get Well and Live Well Naturally at Naples Center for Functional ...
    Jun 6, 2025 · Founded in 1998 by board-certified neurologist Dr. David Perlmutter, the Perlmutter Health Center emphasized empowering patients with ...
  15. [15]
    FL DOH MQA Search Portal | Practitioner Profile
    Primary Practice Address. DAVID PERLMUTTER. 2205 Beacon 2205 Beacon Lane. NAPLES, FL 34103. Medicaid. This practitioner does NOT participate in the Medicaid ...
  16. [16]
    PERLMUTTER DAVID MD PA - 800 Goodlette Rd N, Naples, Florida
    800 Goodlette Rd N Ste 270 Naples, FL 34102 Directions (239) 649-7400 Call Now Visit Website http://www.drperlmutter.com<|separator|>
  17. [17]
    Dr. Perlmutter: Gluten Free Diet & The Food For A Healthy Brain
    Dr. Perlmutter is a renowned neurologist whose expertise includes gluten issues, brain health & nutrition, and preventing neurodegenerative disorders.David Perlmutter, MD · Grain Brain · About · Gluten-Free RecipesMissing: practice | Show results with:practice
  18. [18]
    David Perlmutter, MD - Levels
    Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award.Missing: credentials | Show results with:credentials
  19. [19]
    Books and Publications - David Perlmutter M.D.
    Dr. Perlmutter's books have been published in 32 languages and include the #1 New York Times bestseller Grain Brain.Missing: sales | Show results with:sales
  20. [20]
    Grain Brain by David Perlmutter, MD | Hachette Book Group
    Free delivery over $35 30-day returnsThe devastating truth about the effects of wheat, sugar, and carbs on the brain, with a 4-week plan to achieve optimum health.
  21. [21]
    Dr. David Perlmutter '76 Discusses Findings of Best-Selling Book on ...
    Dec 17, 2013 · Released in September, Grain Brain by neurologist Dr. David Perlmutter '76 was listed in the top ten on The New York Times nonfiction hardcover best-sellers ...
  22. [22]
    Brain Maker by David Perlmutter, MD | Hachette Book Group
    Free delivery over $35 30-day returnsBy David Perlmutter, MD. Formats and Prices. On Sale: Apr 28, 2015. Page Count: 320 pages. Publisher: Little Brown Spark. ISBN-13: 9780316380089. Price. $14.99 ...
  23. [23]
    Brain Wash: Detox Your Mind for Clearer Thinking, Deeper ...
    $$14.99 Rating 3.8 (2,440) Jan 14, 2020 · David Perlmutter, #1 New York Times bestselling author of Grain Brain, and Dr. Austin Perlmutter, his son, explore how modern culture threatens ...<|separator|>
  24. [24]
    Drop Acid by David Perlmutter, MD | Hachette Book Group
    In stock Free delivery over $35Offering an engaging blend of science and practical advice, Drop Acid exposes the deadly truth about uric acid and teaches invaluable strategies to manage its ...Missing: summary | Show results with:summary
  25. [25]
    Drop Acid: The Surprising New Science of Uric Acid - Dr. Perlmutter
    Offering an engaging blend of science and practical advice, Drop Acid exposes the deadly truth about uric acid and teaches invaluable strategies to manage its ...
  26. [26]
    The Grain Brain Whole Life Plan by David Perlmutter, MD
    In stock Free delivery over $35 30-day returnsHe is the author of the New York Times bestsellers Grain Brain, The Grain Brain Cookbook, and Brain Maker, as well as The Better Brain Book and Raise a Smarter ...
  27. [27]
    Dr. Perlmutter and Grain Brain on Dr. Oz
    Oct 22, 2013 · As many of you know, yesterday I had the opportunity to spend some time with my good friend Dr. Oz discussing my new book, Grain Brain, ...
  28. [28]
    Episode 93: Dr. David Perlmutter | What You Eat Affects Brain ...
    Feb 20, 2020 · Perlmutter is a Board-Certified Neurologist and four-time New York Times bestselling author. He serves as a medical advisor for The Dr. Oz Show ...
  29. [29]
    Dr. David Perlmutter, World-Renowned Neurologist and Glutathione ...
    Apr 13, 2009 · David Perlmutter, World-Renowned Neurologist and Glutathione Expert, Featured With Dr. Oz on Oprah and Friends, Joins Scientific Advisory Board ...
  30. [30]
    The Empowering Neurologist™ - David Perlmutter M.D.
    The Empowering Neurologist is my interview series with some of the most exciting practitioners and thought leaders in health and wellness.
  31. [31]
    Dr. David Perlmutter- Diet Affects Behavior - Lewis Howes
    Jan 5, 2022 · Dr. Perlmutter and I talked about the culprits behind diseases, how diet affects behavior, and how diet and exercise are the best medicines around.<|separator|>
  32. [32]
    David Perlmutter, MD, FACN - World-Renowned Neurologist - A4M
    Jun 6, 2017 · Listen to Dr. David Perlmutter on Episode 6 of "Redefining Medicine" the best medical podcasts for doctors at A4M. As a world-renowned neurologist, ...
  33. [33]
    Podcast Episode 214 - David Perlmutter - A4M
    Dec 26, 2021 · Dr. Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the ...<|separator|>
  34. [34]
    Professional Appearances - David Perlmutter M.D.
    Professional Appearances ; A4M. The Venetian And Palazzo Resort, Las Vegas, NV. December 13 – 15, 2025 ; Eudemonia. Hilton West Palm Beach, FL. November 13-16, ...
  35. [35]
    Architecting the Perfect Diet - David Perlmutter M.D.
    The food pyramid, the former USDA nutritional guidelines that underpin “My Plate”, is built on an uneasy foundation that puts brain health at risk.
  36. [36]
    How Are We to Interpret the New Dietary Guidelines for Americans?
    The diet recommends greater than 50% of calories coming from carbohydrates and includes three servings of refined grains per day and up to 10% of calories ...Missing: advocacy | Show results with:advocacy
  37. [37]
    Simple Carbs Threaten the Brain: Insulin Resistance and Alzheimer's
    Changes in brain energetics are happening much earlier than we think, showing a dangerous link between diabetes, insulin resistance and Alzheimer's disease.
  38. [38]
    Grain Brain to Today: The Evidence Against Sugar - Dr. Perlmutter
    Aug 30, 2025 · Back then, the idea that sugar and carbohydrates could play a role in Alzheimer's disease and other forms of cognitive decline was considered ...
  39. [39]
    Elevated Blood Sugar Shrinks the Brain - David Perlmutter M.D.
    Studies have demonstrated that the higher your blood sugar, the more rapidly your brain will shrink.Missing: HbA1c | Show results with:HbA1c
  40. [40]
    HbA1c, diabetes and cognitive decline: the English Longitudinal ...
    The aim of the study was to evaluate longitudinal associations between HbA1c levels, diabetes status and subsequent cognitive decline over a 10 year follow-up ...
  41. [41]
    The Argument of Grain Brain - David Perlmutter M.D.
    If you haven't read Grain Brain yet, the main thesis of the book is this: grains, gluten and carbs have an adverse role on the health of our brains.
  42. [42]
    Optimal Diet for Brain Health - David Perlmutter M.D.
    It started with Grain Brain, but it is increasingly clear that a high-fat, high-fiber, low-carb diet is a scientifically validated and viable nutrition ...
  43. [43]
    Prevention of Alzheimer's - David Perlmutter M.D.
    Sep 23, 2016 · Alzheimer's is preventable by favoring a low-carb, sugar-free diet that keeps blood sugar in check, similar to that advised in Grain Brain.
  44. [44]
    Brain Maker - David Perlmutter M.D.
    Perlmutter explains the potent interplay between intestinal microbes and the brain, describing how the microbiome develops from birth and evolves based on ...Missing: function | Show results with:function
  45. [45]
    Yes, Probiotics Can Help the Brain - David Perlmutter M.D.
    Aug 21, 2023 · Yes, Probiotics Can Help the Brain · Producing Neurotransmitters: Gut bacteria are responsible for the production of neurotransmitters such as ...
  46. [46]
    The Gut-Brain Axis: The Missing Link in Depression - Dr. Perlmutter
    Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis ...Missing: vagus antibiotics
  47. [47]
    Gut Bacteria Chart Our Destiny - David Perlmutter MD
    Jun 2, 2015 · Research links alterations in the gut microbiome to diseases such as inflammatory bowel disease, asthma, arthritis, ...
  48. [48]
    Control of Brain Development, Function, and Behavior by the ...
    The gut bacteria can impact neurological outcomes—altering behavior and potentially affecting the onset and/or severity of nervous system disorders.
  49. [49]
    Root Causes of Autism - David Perlmutter M.D.
    The more we study, the more we begin to learn what could be at the root of autism, and factors that impact baseline risk for autism, like childhood exposure to ...
  50. [50]
    Stress & The Gut-Brain Axis: Regulation by The Microbiome
    The gut microbiota has been implicated in a variety of stress-related conditions including anxiety, depression and irritable bowel syndrome.
  51. [51]
    The Empowering Neurologist - David Perlmutter, MD and Dr. Derrick ...
    In this video interview with Dr. Derrick MacFabe we discuss the fascinating new research that connects changes in gut bacteria to autism spectrum disorder.Missing: axis vagus nerve antibiotics
  52. [52]
    Finding the Right Probiotic - David Perlmutter M.D.
    My advice: focus on the five key Lactobaccilus and Bifidobacterium strains I identify as key in Brain Maker, and look for a supplement that has anywhere from 10 ...
  53. [53]
    Feeding your Good Bacteria with Prebiotics - David Perlmutter M.D.
    A diet that includes sufficient amounts of "prebiotics feeds your success. Prebiotics include garlic, onion, Jerusalem artichoke, dandelion greens and more.
  54. [54]
    The Inverse Food Pyramid - YouTube
    Jan 2, 2014 · Dr. David Perlmutter has long believed that the nutritional guidelines put out by the USDA favor carbohydrate and sugar-rich foods, like ...Missing: criticism | Show results with:criticism
  55. [55]
    Why We Got Fatter During The Fat-Free Food Boom : The Salt - NPR
    Mar 28, 2014 · In the 1970s, the U.S. Dietary Goals advised Americans to cut back on fat and eat more carbs to lower the risk of heart disease.
  56. [56]
    How America's diet has changed over time - Pew Research Center
    Dec 13, 2016 · Americans consume 29% more grains, mostly in the form of breads, pastries and other baked goods, than they did in 1970 – the equivalent of 122.1 ...Missing: post- epidemic
  57. [57]
    The Origins of the Obesity Epidemic in the USA–Lessons for Today
    Oct 12, 2022 · The obesity epidemic appeared in the USA in 1976–1980 and then spread across Westernized countries. This paper examines the most likely causes of the epidemic ...
  58. [58]
    Adult obesity: Is childhood sugar intake in the '70s to blame?
    Sep 25, 2019 · To be specific, around 15% of adults had obesity in 1970. By 2016, that percentage had increased to almost 40%Trusted Source . Numerous studies ...Missing: shifts post-
  59. [59]
    [PDF] How the U.S. Low-Fat Diet Recommendations of 1977 Contributed ...
    Apr 29, 2016 · The 1977 US low-fat guidelines, intended to reduce diet-related diseases, caused an overhaul of the food industry and contributed to increased  ...<|separator|>
  60. [60]
    Taking Control of the “Alzheimer's Gene” - Dr. Perlmutter
    Apr 24, 2018 · Carrying the APOE4 gene is one of them, as it is known that individuals who do carry this allele have increased accumulation of amyloid protein in their brains.
  61. [61]
    Effect of low carbohydrate diets on insulin resistance and the ...
    This review outlines recent research in the application of low carbohydrate diets (LCD) for insulin resistance (IR) and metabolic syndrome (MetS).Missing: peer | Show results with:peer
  62. [62]
    The effects of low-carbohydrate diet on glucose and lipid ... - Frontiers
    Regarding other metabolic outcomes, low-carbohydrate diets were associated with significant reductions in body weight, BMI, DBP, and waist circumference ...
  63. [63]
    A low-carbohydrate survey: Evidence for sustainable metabolic ...
    Dec 21, 2017 · Numerous clinical trials have demonstrated the efficacy of low-carbohydrate diets in reversing metabolic syndrome and its associated disorders.Missing: peer | Show results with:peer
  64. [64]
    Dietary carbohydrate restriction as the first approach in diabetes ...
    The lower carbohydrate diets were associated with significant decreases in body weight, body mass index, TG levels, and blood pressure; additionally, they ...
  65. [65]
    David Perlmutter, MD, FACN, ABIHM: Combating inflammation in the ...
    David Perlmutter, MD, FACN, ABIHM: Combating inflammation in the brain--what is good for the body is good for the brain. Interview by Karen Burnett.
  66. [66]
    Ketogenic Diets for Adult Neurological Disorders - PMC
    The current review highlights the evidence supporting the use of ketogenic diet therapies in the management of a growing number of neurological disorders in ...
  67. [67]
    The Expanding Role of Ketogenic Diets in Adult Neurological ...
    Aug 8, 2018 · The current review highlights the evidence supporting the use of ketogenic diet therapies in the management of adult epilepsy, ...
  68. [68]
    Multiple Sclerosis - Prebiotic Foods May Make a Huge Difference
    This research would indicate that it may be reasonable for MS patients to consider increasing their consumption of prebiotic foods as a method of achieving ...Missing: microbiome | Show results with:microbiome
  69. [69]
    https://drperlmutter.com/study/neuroprotective-effects-cocoa-flavanol-influence-cognitive-performance-2/
  70. [70]
    Systems Biology Meets Functional Medicine - PMC - NIH
    2002: David Perlmutter, MD, for his contributions to the development of functional neurology. 2003: Walter Willett, MD, DrPH, for his contributions to the ...
  71. [71]
    https://drperlmutter.com/study/dietary-sugar-intake-genetic-susceptibility-risk-dementia-prospective-cohort-study/
  72. [72]
    https://www.foodnavigator-usa.com/Article/2013/09/18/Grain-Brain-Experts-say-advice-to-avoid-grains-is-unhelpful
  73. [73]
    Grain Brain expert review • Red Pen Reviews
    May 9, 2018 · Grain Brain argues that carbohydrate and gluten, paired with sedentary behavior and insufficient sleep, are harmful to the brain.<|separator|>
  74. [74]
    https://www.sciencedirect.com/science/article/abs/pii/S0140673625015338
  75. [75]
    Grain Brain - Scientific Validation - David Perlmutter M.D.
    Oct 6, 2014 · The recommendations in Grain Brain, beyond just reducing risk for brain degeneration are now shown to actually improve brain function in those who are already ...Missing: empirical | Show results with:empirical
  76. [76]
    Grain Brain is a Best Seller! - David Perlmutter M.D.
    Sep 27, 2013 · Grain Brain has made the New York Times' Best Sellers list, along with similar announcements from USA Today and The Wall Street Journal.Missing: sales impact
  77. [77]
    Digital Natives Group Congratulates Dr. David Perlmutter and ...
    Sep 17, 2018 · Grain Brain has repeatedly topped numerous bestseller lists since publication, including those from the New York Times, Wall Street Journal, and ...
  78. [78]
    Grain Brain's David Perlmutter On Benefits of Low Carb, High Fat Diet
    Dec 18, 2018 · A book that focused on the powerfully threatening nature of sugar, carbs and gluten in terms of brain health, functionality, and disease resistance.Missing: evidence | Show results with:evidence
  79. [79]
    But It's Gluten-Free! - David Perlmutter M.D.
    Jun 20, 2014 · My prediction is an eventual backlash toward the entire 'gluten-free' movement within the next couple of years. Do you agree, or think I'm off ...Missing: trends | Show results with:trends
  80. [80]
    Science, advocacy, and quackery in nutritional books: an analysis of ...
    Mar 17, 2020 · For example, one author (Perlmutter) was listed by Quackwatch in a list of “Promoters of Questionable Methods and/or Advice”. He has received ...<|control11|><|separator|>
  81. [81]
    Food Choices Change Our Gene Expression - David Perlmutter M.D.
    Aug 14, 2015 · The idea that our choices, in terms of the foods we eat, the exercise we get, and the levels of stress in our day-to-day lives, all influence the expression of ...
  82. [82]
    CQ Researcher - Food Policy Debates
    Oct 3, 2014 · According to David Perlmutter, a neurologist and the author of Grain Brain, in the last 40 years people have become addicted to gluten ...
  83. [83]
    The Empowering Neurologist Podcast
    The Empowering Neurologist is an interview series with some of the most exciting thought leaders in the field of health and wellness.
  84. [84]
    https://puritycoffee.com/blogs/blog/alzheimers-awareness-interview-with-dr-perlmutter
  85. [85]
    Grain Brain wellness guru Dr. David Perlmutter meets Prince Charles
    Jul 6, 2022 · “Our discussion laid bare the direct global health impact of the pervasive consumption of highly processed foods and refined carbohydrates.Missing: influence debates
  86. [86]
    Linus and Ava Helen Pauling Award in Functional Medicine
    David Perlmutter, MD was recognized for pioneering research and clinical work on the role of diet and nutrition in brain-related disorders. 2001. Gerald Reaven, ...
  87. [87]
    [PDF] David Perlmutter, MD, FACN, ABIHM: Combating Inflammation in the ...
    In 2002, he was awarded the Linus Pauling Award for his pioneering work in innovative approaches to neurological dis- orders. In addition, he received the ...
  88. [88]
    David Perlmutter - American Nutrition Association
    He has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition, and is a ...Missing: publications | Show results with:publications
  89. [89]
    David Perlmutter, MD, FACN, ABIHM - A4M
    David Perlmutter, MD, FACN, ABIHM ... peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.Missing: publications | Show results with:publications
  90. [90]
    David Perlmutter, MD - Board-Certified Neurologist - LinkedIn
    Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the ...Missing: biography credentials
  91. [91]
    ANA Training Programs - American Nutrition Association
    David Perlmutter is a board-certified neurologist and New York Times bestselling author. He serves on the American Nutrition Association's Scientific ...Missing: functional | Show results with:functional