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Prostatic artery embolization

Prostatic artery embolization (PAE) is a minimally invasive endovascular procedure primarily used to treat benign prostatic hyperplasia (BPH), a common condition in older men characterized by prostate enlargement leading to lower urinary tract symptoms (LUTS), and also employed for symptom management in prostate cancer, such as urinary obstruction or hemorrhage. The technique involves selectively occluding the prostatic arteries supplying blood to the prostate gland, inducing ischemia that causes the hyperplastic or tumoral tissue to shrink and thereby relieving obstructive symptoms such as urinary frequency, urgency, and weak stream.^[1]^[2]^[3] Developed in the early 2000s and refined over the past decade with advancements in microcatheter technology and imaging guidance, PAE is typically performed on an outpatient basis under local anesthesia by interventional radiologists. The procedure accesses the arterial system through the femoral or radial artery, uses fluoroscopy and cone-beam computed tomography (CBCT) to identify and catheterize the often tortuous prostatic arteries, and deploys embolic microspheres (usually 100-500 µm in size) to achieve flow stasis while minimizing non-target embolization.^[1]^[4] Patient preparation includes pre-procedural imaging (e.g., MRI or CT angiography) to assess vascular anatomy, antibiotic prophylaxis, and evaluation to exclude active prostate cancer or other malignancies for BPH cases, or active urinary tract infection.^[4] PAE is indicated for men with moderate-to-severe LUTS refractory to pharmacotherapy, prostate volumes exceeding 80 mL (making them poor candidates for transurethral resection of the prostate, TURP), urinary retention, or surgical comorbidities such as advanced age or anticoagulation needs.^[4] Systematic reviews and long-term studies involving thousands of patients report technical success rates over 95%, with significant reductions in prostate volume (20-40%), prostate-specific antigen (PSA) levels (up to 30%), and International Prostate Symptom Score (IPSS) improvements of 70-80% at 12 months, comparable to TURP but with superior preservation of sexual function and ejaculatory ability.^[1]^[4] In catheter-dependent patients, PAE enables successful removal in up to 87% of cases.^[4] The safety profile of PAE is favorable, with most complications being minor and self-limiting, including post-embolization syndrome (fever, pain; ~30%), dysuria (9%), urinary tract infections (8%), and hematuria (6%), classified as Clavien-Dindo Grade I-II.^[4] Major adverse events, such as non-target embolization leading to rectal or bladder ischemia, occur in under 2% and are mitigated by techniques like protective coil placement in high-risk vessels.^[1] Compared to surgical alternatives like TURP or laser enucleation, PAE offers lower rates of bleeding, incontinence, and erectile dysfunction, shorter hospital stays (often same-day discharge), and better cost-effectiveness, though it may require re-intervention in 15-20% of cases over 5 years due to incomplete central gland necrosis.^[1]^[2] Recent updates as of 2025, including 10-year follow-up data from large cohorts affirming PAE's durability with low reintervention rates (e.g., <10% at 5+ years), the 2024 inclusion in American Urological Association (AUA) guidelines as a recommended minimally invasive treatment, and its conditional recommendation in European Association of Urology (EAU) guidelines for patients accepting potentially less optimal outcomes than surgery, support PAE's role in BPH and prostate cancer management, with ongoing research exploring optimized embolic agents and patient selection criteria to enhance long-term outcomes.^[1]^[5]^[6]^[7]

Overview

Definition and mechanism

Prostatic artery embolization (PAE) is a minimally invasive endovascular procedure designed to treat benign prostatic hyperplasia by selectively occluding the prostatic arteries to reduce blood supply to the prostate gland.^[1] Performed via a transcatheter approach, typically through the femoral or radial artery, PAE involves the delivery of embolic agents to block arterial flow, thereby inducing targeted ischemia without the need for surgical incision.^[4] The mechanism of PAE relies on the induction of ischemia in the hypervascular prostate tissue, which leads to coagulation necrosis, followed by an inflammatory response and eventual atrophy and shrinkage of the gland. This ischemic effect causes tissue death in the embolized regions, observed as areas of infarction on post-procedure imaging, and results in a progressive volume reduction of approximately 20–40% over several months. Post-embolization, neovascularization may occur as a compensatory response, potentially stabilizing the reduced prostate size without significant regrowth.^[4]^[8] Anatomically, PAE targets the prostatic arteries, which primarily arise from branches of the internal iliac artery, including the superior vesical artery (in about 30% of cases), internal pudendal artery (30%), common gluteal-pudendal trunk (15%), or obturator artery (15%). These vessels supply both the central and peripheral zones of the prostate, though anatomical variations—such as collateral branches from vesical or rectal arteries—are common and must be identified to ensure precise embolization and avoid non-target effects.^[1]^[9] Common embolic agents for PAE include non-spherical polyvinyl alcohol (PVA) particles (100–300 µm) and spherical particles such as tris-acryl gelatin microspheres (300–500 µm) or polyzene-coated hydrogel microspheres (250–400 µm). Particle size selection is critical: smaller particles (100–300 µm) allow deeper penetration into the prostatic microvasculature for more complete ischemia but increase the risk of non-target embolization to adjacent structures like the bladder or rectum, while larger particles (>300 µm) prioritize safety by reducing such complications without compromising efficacy.^[1]^[4]

Historical development

The concept of prostatic artery embolization (PAE) emerged from advancements in transarterial embolization techniques developed in the 1990s for treating uterine fibroids, where selective occlusion of blood supply led to tissue ischemia and volume reduction, inspiring similar applications for benign prostatic hyperplasia (BPH).^[10] Early explorations in prostatic embolization focused on managing severe hematuria, with the first reported case in 2000 by DeMeritt et al., who performed bilateral prostatic artery embolization in a 76-year-old man with BPH-related lower urinary tract symptoms (LUTS), resulting in symptom improvement and prostate volume reduction.^[11] This built on foundational animal studies, including a 1980 experiment by Darewicz evaluating internal iliac artery embolization effects on canine prostates, and more targeted early 2000s research, such as a 2007-2008 preclinical canine model at Harvard Medical School using hormone-induced hyperplasia to demonstrate feasibility and ischemic volume reduction.^[12] The first intentional human applications for BPH occurred in 2008-2010 through pilot studies in Brazil and Portugal. In June and July 2008, Francisco Cesar Carnevale at the University of São Paulo performed PAE on two patients with acute urinary retention due to BPH, achieving catheter removal and symptom relief, with results published in 2010.^[13] Concurrently, João Martins Pisco in Portugal initiated PAE in March 2009 at St. Louis Hospital, Lisbon, treating patients with moderate to severe LUTS, and reported early safety and efficacy in subsequent studies. These efforts established PAE's ischemic mechanism—occlusion of prostatic arteries using embolic agents to induce targeted glandular atrophy—validating principles from prior embolization therapies.^[14] Regulatory milestones accelerated PAE's adoption in the 2010s. In Europe, CE marking for Embosphere microspheres specifically for PAE was granted in 2013, enabling broader clinical use across the continent.^[15] In the United States, the FDA classified the prostatic artery embolization device as Class II with special controls via a final rule in November 2017, following 510(k) clearance for embolic agents like Embospheres for BPH treatment.^[16] Brazil approved PAE through the Federal Council of Medicine in 2013 (initial) and 2016 (final), with a dedicated reimbursement code added in 2022. By 2023, PAE gained endorsement in major guidelines, including the American Urological Association's update recommending it as an option for LUTS/BPH in select patients.^[17] Technological advances post-2010 enhanced procedural precision and outcomes. Improvements in microcatheters allowed better navigation of complex prostatic vascular anatomy, while refinements in embolic particles, such as 100-300 μm non-spherical microspheres, optimized distal occlusion and minimized nontarget embolization.^[18] The introduction of cone-beam CT in 2013 revolutionized vessel mapping, providing 3D angiography during procedures to confirm prostatic artery targeting and reduce radiation exposure compared to traditional digital subtraction angiography. PAE's global spread began in Europe and South America, where early adopters like Pisco and Carnevale conducted training programs, expanding to over 1,000 procedures in single centers by 2020. By the mid-2020s, adoption extended to North America, Asia, and other regions, supported by international societies such as the Cardiovascular and Interventional Radiological Society of Europe and the Society of Interventional Radiology, with endorsements from the National Institute for Health and Care Excellence and European Association of Urology facilitating wider implementation.^[12]

Indications

Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) is a common non-malignant condition characterized by the enlargement of the prostate gland, which compresses the urethra and causes bladder outlet obstruction. This leads to lower urinary tract symptoms (LUTS) that significantly impact quality of life. The prevalence of BPH increases with age, affecting approximately 50% of men over 50 years and rising to 90% in those over 80 years.^[19]^[20] The primary LUTS targeted by prostatic artery embolization (PAE) in BPH include storage symptoms—such as urinary urgency, increased frequency, and nocturia—and voiding symptoms, including weak urine stream, hesitancy, intermittency, and incomplete emptying, which can progress to acute urinary retention. These symptoms are quantified using the International Prostate Symptom Score (IPSS), a validated seven-item questionnaire where scores range from 0 to 35; an IPSS greater than 13 typically indicates moderate to severe symptoms that may require intervention beyond conservative management.^[21] PAE is indicated as a minimally invasive alternative to surgical treatments like transurethral resection of the prostate (TURP) for patients with BPH who are poor surgical candidates due to comorbidities or high anesthetic risk. It is particularly suitable for men with large prostates exceeding 80 mL, where traditional minimally invasive therapies often yield suboptimal results or higher complication rates.^[22]^[23] Clinical evidence from meta-analyses supports PAE's role in BPH management, demonstrating symptom improvement rates with 70-80% reductions in IPSS scores at 12 months post-procedure, reflecting substantial relief in LUTS severity from baseline values around 20-25. Prostate volume reductions of 30-40% have also been consistently observed in these analyses, based on data from studies up to 2025, underscoring PAE's efficacy in alleviating obstruction through targeted ischemia.^[24]^[25]

Prostate cancer symptom management

Prostatic artery embolization (PAE) has been explored as an emerging palliative option for lower urinary tract symptoms (LUTS) or urinary retention in patients with advanced prostate cancer, particularly when radiation or hormone therapy proves insufficient to manage these issues. This approach provides a minimally invasive option that avoids the risks associated with surgical interventions, making it suitable for frail or high-risk patients who may not tolerate procedures like transurethral resection of the prostate. However, PAE for PCa symptom management remains investigational and is not included in current AUA or EAU guidelines as a standard treatment.^[26]^[27] LUTS in prostate cancer often overlap with those seen in benign prostatic hyperplasia, such as urgency and weak stream, but PAE's role here emphasizes symptom relief amid ongoing oncologic management.^[28]^[29]^[30] Specific applications of PAE in prostate cancer include adjunctive use alongside radiation therapy to enhance local control in cases with low prostate volumes or limited metastatic burden, as well as support for urinary catheter removal in retention cases. Recent studies report catheter independence in 77-80% of affected patients within one month post-procedure, facilitating improved quality of life without reliance on indwelling devices. While direct combinations with androgen deprivation therapy remain under exploration, PAE integrates well into multimodal regimens to address symptomatic progression.^[28]^[29]^[30] Mid-2020s clinical trials and meta-analyses demonstrate substantial International Prostate Symptom Score (IPSS) improvements following PAE, with mean reductions of 10-12 points—representing 40-60% improvement from severe baseline scores—comparable to outcomes in benign prostatic hyperplasia treatment. PAE has proven safe in prostates previously irradiated for cancer, achieving up to 90% symptom relief in radiation-induced prostatitis without increased toxicity. Additionally, unlike surgical alternatives, PAE avoids worsening erectile dysfunction, preserving sexual function in the majority of patients.^[28]^[30]^[31] Despite these benefits, PAE is not a curative therapy for prostate cancer, with symptom control rates of approximately 90% for LUTS improvement, though limited to palliation and no established impact on disease progression. Potential non-target effects on tumor vascularity remain debated, as embolization may induce localized ischemia without altering overall cancer advancement or metastatic spread. Limitations include small sample sizes in existing studies and variable long-term durability, underscoring the need for larger randomized trials to refine its oncologic role.^[28]^[30]

Patient Selection

Evaluation criteria

Patient evaluation for prostatic artery embolization (PAE) begins with a comprehensive diagnostic workup to confirm lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH) and assess suitability for the procedure. Patient selection aligns with guidelines such as the 2023 AUA amendment, which endorses PAE for men with moderate-to-severe LUTS due to BPH.^[17] This includes a digital rectal exam (DRE) to evaluate prostate size and consistency, prostate-specific antigen (PSA) testing to screen for prostate cancer, uroflowmetry to measure peak urinary flow rate (Qmax), and post-void residual (PVR) urine measurement to quantify bladder emptying. Interventional radiologists should assess vascular risk factors, including history of claudication or peripheral artery disease, potentially using cross-sectional imaging.^[17] Prostate volume is determined via transrectal ultrasound (TRUS) or magnetic resonance imaging (MRI), with volumes of 60 g or greater generally considered suitable for PAE candidacy, as outcomes may be less predictable in smaller glands.^[17]^[4] Symptom severity is quantified using validated scoring systems, such as the International Prostate Symptom Score (IPSS) questionnaire, which assesses LUTS on a scale from 0 to 35, with scores indicating moderate (8-19) to severe (20-35) symptoms that warrant intervention.^[23] Uroflowmetry-derived Qmax values below 15 mL/s suggest significant bladder outlet obstruction, further supporting PAE as a treatment option.^[32] These tools help differentiate BPH-related obstruction from other causes of LUTS, ensuring appropriate patient selection.^[4] Pre-procedure imaging is essential to map the prostatic arteries and identify potential vascular anomalies. Pelvic angiography, computed tomography angiography (CTA), or MRI angiography is performed to visualize arterial origins, patency, and any iliac artery tortuosity or calcifications that could complicate access.^[32] These modalities also aid in prostate volume assessment and exclusion of non-BPH etiologies, with CTA often enhanced by sublingual nitroglycerin for optimal artery delineation.^[23] A multidisciplinary approach involving urologists and interventional radiologists is recommended to review findings, confirm eligibility, and rule out alternative LUTS causes such as urethral stricture or detrusor dysfunction.^[32] Patient education during consultation emphasizes realistic expectations, including a typical onset of symptom relief within 1-3 months post-procedure, alongside discussions of benefits, risks, and alternatives to facilitate informed consent.^[4]

Contraindications

Prostatic artery embolization (PAE) has specific contraindications that must be assessed during patient selection to ensure safety and efficacy. Absolute contraindications include conditions that pose significant risks or preclude procedural success, such as active urinary tract infection, which can lead to sepsis or procedure failure if not resolved prior to intervention.^[33]^[34] Prostate cancer is generally contraindicated except in palliative settings for symptom relief, as PAE does not address the malignancy itself.^[34]^[33] Severe coagulopathy, defined as an international normalized ratio (INR) greater than 1.5 or history of significant vascular interventions like lower extremity bypass grafts, increases the risk of bleeding or access complications.^[35] Allergy to iodinated contrast media and severe renal dysfunction (e.g., stage 4 chronic kidney disease) are also absolute, necessitating alternative imaging or exclusion due to the reliance on angiography and risk of nephropathy.^[17]^[33] Severe atherosclerosis or vascular tortuosity that precludes access is an absolute contraindication.^[17] Relative contraindications involve factors that may complicate PAE but do not universally preclude it, often requiring individualized risk-benefit assessment. These include a small prostate volume less than 60 g, where embolization may yield limited symptom improvement due to insufficient vascular targeting.^[17]^[23] Mild tortuous iliac or pelvic arteries, common in older patients, can hinder catheter navigation and increase procedural time or failure rates.^[35]^[33] Prior pelvic radiation therapy elevates the risk of non-target embolization to adjacent structures like the bladder or rectum.^[17] Severe comorbidities, such as New York Heart Association (NYHA) class IV heart failure, heighten perioperative risks including hemodynamic instability.^[34]^[17] Additionally, lower urinary tract symptoms (LUTS) stemming from non-benign prostatic hyperplasia (BPH) etiologies, like urethral stricture or neurogenic bladder, render PAE ineffective.^[17]^[23] Risk stratification for PAE involves evaluating vascular access challenges, particularly in patients with atherosclerosis or anticoagulation needs, where tools like the CHA2DS2-VASc score may inform thromboembolic risks during femoral access, though it is not specific to PAE.^[35] Anticoagulation management is critical, often requiring temporary bridging or reversal to mitigate bleeding hazards in coagulopathic patients.^[35] When contraindications are identified, alternatives such as transurethral resection of the prostate (TURP) or medical therapy with alpha-blockers and 5-alpha reductase inhibitors should be considered, with re-evaluation possible after resolution of reversible issues like infection.^[17]^[33] This approach integrates findings from initial evaluation, including International Prostate Symptom Score (IPSS) assessment and imaging, to guide referrals.^[23]

Procedure

Preparation and imaging

Patient preparation for prostatic artery embolization (PAE) involves standard measures to minimize risks associated with the interventional procedure. Patients are typically advised to fast for 6 to 8 hours prior to the intervention to facilitate potential sedation, while adequate hydration is encouraged to support renal function during contrast administration.^[36] Prophylactic antibiotics, such as ciprofloxacin or cefazolin, are administered to prevent urinary tract infections, often starting 24 hours before the procedure.^[37] ^[38] PAE is particularly suitable for patients on anticoagulant or antiplatelet therapy, as the procedure generally does not require discontinuation of these medications, reducing perioperative bleeding risks compared to surgical alternatives.^[37] ^[4] Vascular access for PAE is obtained via puncture of the common femoral or radial artery under local anesthesia, with the femoral approach being more commonly utilized due to familiarity and equipment availability.^[37] ^[38] Sedation is not routinely required but may include conscious sedation with agents like midazolam and fentanyl if needed for patient comfort, avoiding general anesthesia to maintain the minimally invasive nature of the procedure.^[4] ^[38] Initial imaging begins with digital subtraction angiography (DSA) to delineate the internal iliac artery branches and identify potential prostatic artery origins, typically performed with ipsilateral oblique projections (30°–40° oblique and 10°–15° caudocranial angulation) to optimize visualization of the prostate blush.^[37] ^[4] Cone-beam computed tomography (CBCT) is then employed for three-dimensional mapping of the prostatic arteries, involving selective injection of 30–40 mL of contrast at 2–6 mL/s, which enables identification of target vessels in 90–98% of cases for at least one prostatic lobe.^[37] ^[38] Equipment preparation includes selection of microcatheters sized 2.0–2.8 Fr for superselective catheterization of the prostatic arteries, paired with hydrophilic guidewires (0.014–0.016 inch) to navigate tortuous vessels.^[38] Embolic particles, such as microspheres (300–500 μm) or polyvinyl alcohol particles (100–300 μm), are prepared by suspending them in a mixture of contrast and saline (e.g., 9 mL saline, 9 mL contrast, and 2 mL embolic agent) to ensure even distribution and controlled delivery.^[37] ^[38]

Embolization technique

The embolization technique in prostatic artery embolization (PAE) primarily employs a bilateral approach to achieve comprehensive ischemia of the prostate gland, targeting both prostatic arteries for optimal clinical outcomes, with technical success rates of 90–98%.^[4] Selective catheterization begins with advancing a microcatheter coaxially through a 5-F guiding catheter into the internal iliac artery, followed by superselective navigation into the prostatic artery branches, including the prostatic-central (anteromedial) and prostatic-peripheral (posterolateral) vessels, while crossing potential collateral branches to avoid non-target embolization.^[4] Superselective advancement of the microcatheter into intraprostatic branches is critical, often guided by the PErFecTED (Proximal Embolization First, Then Embolize Distal) technique, which involves initial proximal embolization to reduce inflow, followed by distal targeting of the central gland branches to enhance prostate ischemia.^[4] The embolization process entails slow, diluted injection of embolic particles—typically 300–500 μm microspheres—under continuous fluoroscopy to monitor flow and prevent reflux, continuing until near-stasis (reduced antegrade flow) is achieved as the endpoint, indicating near-complete occlusion of the prostatic arteries.^[4]^[39] A typical dose ranges from 1–2 mL of embolic agent per side, delivered in a highly diluted manner (e.g., 1:10 ratio) at rates below 2 mL/min to ensure even distribution and minimize risks like nontarget embolization.^[38] Vasodilators such as nitroglycerin may be injected prior to embolization to widen intraprostatic arteries, allowing for greater embolic delivery.^[4] Variations in technique accommodate anatomical challenges; unilateral embolization is performed when bilateral access is not feasible due to vascular tortuosity or occlusion, achieving technical success in approximately 80–90% of such cases, though clinical efficacy may be lower than bilateral PAE (around 50–85% symptom improvement).^[40]^[41] Arterial variants, such as tandem origins or shunts to adjacent structures (e.g., rectum or bladder), are managed by protective coiling of large collaterals or adjusting microcatheter position to isolate prostatic branches before injection.^[39]^[4] The procedure typically lasts 60–120 minutes, depending on vascular complexity and operator experience, with continuous monitoring of vital signs to detect vasospasm or hemodynamic changes.^[4] Contrast volume is limited to under 200 mL to reduce the risk of contrast-induced nephropathy, often aided by cone-beam CT for efficient navigation.^[4]

Post-procedure care

Following prostatic artery embolization (PAE), patients are typically monitored for 4-6 hours in a recovery area to assess for immediate complications such as bleeding or hemodynamic instability.^[4] Bed rest is recommended for 6-24 hours to minimize the risk of hematoma at the access site, with manual groin compression or hemostatic devices applied as needed.^[4] Pain management focuses on the post-embolization syndrome (PES), which includes symptoms like pelvic pain, dysuria, and mild fever, and is addressed with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen; opioids or steroidal anti-inflammatories may be used if symptoms are severe.^[42]^[4] Discharge usually occurs on the same day, 3-6 hours post-procedure, or after overnight observation if urinary retention persists, with criteria including a postvoid residual volume less than 200 mL and stable vital signs.^[43]^[4] Patients receive prescriptions for NSAIDs, a proton pump inhibitor to prevent gastric irritation, and prophylactic antibiotics (e.g., ciprofloxacin) for 5-7 days to mitigate PES and infection risk.^[43]^[4] Instructions emphasize that transient hematuria and dysuria may last 1-2 weeks as part of PES, which is self-limiting within 7 days, and alpha-blockers may be continued or initiated to ease urinary symptoms.^[42]^[43] Follow-up begins with a clinic visit at 1 week to evaluate the access site for hematoma or infection.^[4] Subsequent assessments at 1-3 months include evaluation of the International Prostate Symptom Score (IPSS), uroflowmetry, and quality-of-life measures, with imaging such as ultrasound or MRI performed if complications are suspected.^[43]^[4] Lifestyle recommendations include maintaining hydration to support urinary flow, avoiding heavy lifting or straining for 1-2 weeks, and promptly reporting signs of infection (e.g., fever >38.5°C), severe pain, or rectal bleeding.^[4] Patients with indwelling catheters are advised to return for a voiding trial 2-3 weeks post-procedure.^[43]

Efficacy

Clinical outcomes

Prostatic artery embolization (PAE) demonstrates significant short-term efficacy in alleviating lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia. In randomized controlled trials and large cohort studies, patients experience an average reduction in International Prostate Symptom Score (IPSS) of 10-16 points at 3 months post-procedure, with baseline scores typically around 23 decreasing to 7-13. Improvements in maximum urinary flow rate (Qmax) of approximately 5-7 mL/s, as reported in meta-analyses. Prostate volume reductions of 25-40% are observed by 6 months, often measured via MRI or ultrasound, contributing to sustained symptom relief.^[44]^[45]^[17] Functional outcomes further underscore PAE's benefits, particularly in preserving quality of life aspects beyond basic symptom scores. Among patients with acute urinary retention, 94% achieve catheter independence within 3 months, enabling resumption of normal voiding without indwelling devices. Sexual function is largely maintained, with International Index of Erectile Function (IIEF) scores remaining stable or improving in the majority of cases; studies report no adverse impact on erectile function over 60 months, and many patients experience stable or improved sexual function, with some noting enhancements compared to baseline or medical therapy alone.^[44]^[17]^[44] Subgroup analyses indicate similar IPSS improvements across prostate sizes, with quality-of-life improvements more pronounced for patients with larger prostates (>80 g) at 3-12 months compared to those with smaller glands. Longitudinal data from cohorts followed up to 5 years show durable efficacy, with 60-70% of patients maintaining IPSS reductions of at least 10 points and prostate volume decreases of 20-30% beyond 48 months. Recent 2024-2025 studies confirm this persistence, with reintervention rates remaining below 10% at 3 years.^[44]^[44] Quality-of-life metrics improve significantly post-PAE, aligning with IPSS gains and reflecting broader enhancements in daily functioning and well-being. In mid-term evaluations, quality-of-life scores drop from baseline medians of 5 to 1-2 points, indicating substantial patient-reported benefits that endure over time.^[44]^[45]

Comparisons to alternatives

Prostatic artery embolization (PAE) provides faster symptom relief compared to medical therapies such as alpha-blockers and 5-alpha-reductase inhibitors (5-ARIs) for patients with moderate-to-severe benign prostatic hyperplasia (BPH), with a randomized controlled trial demonstrating a superior reduction of 10.0 points in International Prostate Symptom Score (IPSS) at 9 months versus 5.7 points for combined alpha-blocker and 5-ARI therapy.^[45] PAE also offers more durable outcomes, with lower retreatment rates over time, though it involves higher upfront costs due to the interventional procedure.^[45] In comparison to surgical options like transurethral resection of the prostate (TURP) and holmium laser enucleation of the prostate (HoLEP), PAE achieves similar efficacy in IPSS reduction (weighted mean difference of 2.20 points, not statistically significant), but with advantages in perioperative recovery, including shorter hospital stays (2 days versus 5 days for TURP and 4 days for HoLEP).^[46]^[47] PAE is associated with less bleeding, evidenced by comparable transfusion rates (1.4% versus 1.8% for TURP) but lower urinary retention (3.2% versus 7.1% for TURP), and better preservation of sexual function, with intact ejaculation in over 90% of cases compared to 65% for TURP.^[47]^[46] Relative to other minimally invasive therapies such as Rezūm water vapor therapy and prostatic urethral lift (UroLift), PAE is particularly suitable for larger prostates (>80 mL), where it demonstrates comparable IPSS improvements but superior prostate volume reduction (approximately 20-30% shrinkage). A network meta-analysis indicates PAE edges out Rezūm and UroLift in health-related quality-of-life scores, though reintervention rates for PAE are slightly higher at 12 months (8% versus 5% for UroLift).^[48]^[49] Major urological guidelines position PAE as a viable option for surgical candidates with BPH-related lower urinary tract symptoms. The American Urological Association (AUA) 2024 guideline recommends PAE (conditional recommendation, evidence level Grade B) for men unsuitable for or preferring alternatives to traditional surgery, while the European Association of Urology (EAU) endorses it for moderate-to-severe cases seeking minimally invasive approaches, supported by level 2a evidence as of 2025 updates.^[26]^[6]

Safety and Complications

Adverse events

Prostatic artery embolization (PAE) is associated with a low overall rate of major complications, reported as less than 5% in recent reviews, with the majority classified as Clavien-Dindo grades I-II, indicating minor events requiring no or limited pharmacological intervention.^[44]^[50] The most common adverse event is post-PAE syndrome, occurring in approximately 25% of patients, characterized by pelvic pain, dysuria, and increased urinary frequency or urgency, which typically resolves spontaneously within 3-7 days.^[51] Microscopic hematuria affects 20-30% of cases post-procedure, usually transient and self-limiting without intervention. Transient urinary retention occurs in about 10% of patients, often due to prostatic inflammation and managed with short-term catheterization.^[52]^[23] Minor complications include access site hematoma in 2-5% of patients and balanitis from nontarget embolization of embolic particles in 1-2%, both typically resolving with conservative measures such as observation or topical treatments. Urinary tract infections (UTIs) arise in 5-10% of cases, necessitating antibiotics. Rare major adverse events include non-target embolization causing ischemia or necrosis of adjacent structures such as the bladder, rectum, penis, or scrotum, occurring in less than 2% of cases, with recent 2025 reports highlighting isolated instances managed conservatively or surgically.^[53]^[54] Reintervention rates, including re-embolization, are reported in 10-20% of cases over 3-5 years due to symptom recurrence, though acute re-embolization during the same procedure is rare (<1%). Management of these events emphasizes supportive care, including analgesics for pain and patient education on expected symptoms, with close monitoring during post-procedure recovery.^[44]^[55]

Radiation considerations

Prostatic artery embolization (PAE) involves fluoroscopy-guided imaging, resulting in patient radiation exposure primarily from X-rays during the procedure. The median effective dose (ED) is approximately 17.8 mSv for procedures using fixed interventional fluoroscopy units and 12.3 mSv for mobile units, comparable to 2-3 abdominal CT scans. Peak skin doses average 2.4-2.7 Gy, which exceeds the 2 Gy threshold for potential transient erythema, though clinical follow-up in large cohorts shows no reported skin injuries.^[56] Safety measures in PAE adhere to the ALARA (as low as reasonably achievable) principle to minimize exposure, including pulsed fluoroscopy at lower frame rates (reducing dose-area product by up to 30%), tight collimation to limit the irradiated field, and preferential use of anteroposterior projections (reducing dose by 26.7%).^[56] Operator training and experience are critical, as procedural proficiency correlates with shorter fluoroscopy times (typically 20-50 minutes, averaging around 30 minutes) and lower overall doses.^[56]^[57] Patient-specific risks from radiation in PAE are low, with gonadal doses minimized through standard lead shielding, resulting in negligible impact on fertility or hereditary effects.^[58] The attributable long-term cancer risk is estimated at 0.107-0.123% for fatal cancer induction in a typical 66-year-old patient, considered very low and most relevant for younger individuals.^[59] Recent advances since 2020 include low-dose protocols and virtual injection software, which can halve the number of digital subtraction angiography runs and reduce dose-area product by up to 50%. AI-assisted tools, such as automated vascular segmentation and collimation algorithms, further decrease exposure by 30-50% during cone-beam CT guidance.^[56]^[60]^[61]

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Fifty percent of men older than 50 show evidence of BPH, and the association ... Advances in Outpatient Therapies and Treatment of Benign Prostatic Hyperplasia: A ...Introduction · Epidemiology · Evaluation · Treatment / Management
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The growing problem of an enlarged prostate gland - Harvard Health
Aug 10, 2024 · By age 60, half of all men will have an enlarged prostate, a condition also known as benign prostatic hyperplasia, or BPH. By age 85, the proportion reaches 90 ...
[17]
International Prostate Symptom Score (IPSS) - Medscape Reference
The IPSS is made up of 7 questions related to voiding symptoms. A score of 0 to 7 indicates mild symptoms, 8 to 19 indicates moderate symptoms and 20 to 35 ...
[18]
Prostate Artery Embolization—Review of Indications, Patient ... - MDPI
The study showed a median 10-point reduction in the IPSS score 12 months after PAE compared to the baseline. While statistically significant, this was less ...
[19]
Prostate Artery Embolization—Review of Indications, Patient ... - NIH
Oct 31, 2021 · Multiple studies have shown PAE to be a safe and effective treatment for catheter dependent BPH with significant improvement in quality of life ...
[20]
Outcomes of Prostatic Artery Embolization for Treating Benign ...
Mar 11, 2025 · A meta-analysis highlighted significant reductions across studies in both IPSS, averaging a 14.81 score decrease, and prostate volume, with ...
[21]
Outcomes of Prostatic Artery Embolization for Treating Benign ...
Mar 11, 2025 · A meta‐analysis highlighted significant reductions across studies in both IPSS, averaging a 14.81 score decrease, and prostate volume, with an ...
[22]
Effectiveness and Safety of Prostatic Artery Embolization for Patients ...
Jul 10, 2025 · Prostatic artery embolization (PAE) has received attention to manage the urological symptoms in patients with prostate cancer (PCa).
[23]
Prostatic artery embolization for palliative control of hematuria in ...
Oct 24, 2025 · Conclusion: PAE offers rapid, low-risk palliation for advanced prostate cancer symptoms. While it is a valuable alternative for high-risk ...Missing: LUTS 2024
[24]
Prostate Artery Embolization in the Setting of Prostate Cancer
Jan 28, 2025 · These studies showed that PAE resulted in >90% of men experiencing significant LUTS improvement (ie, LUTS improvement from the severe category ...
[25]
Effect of Prostate Artery Embolization on Erectile Function - PubMed
Findings suggest that prostate artery embolization has no adverse effect on erectile function in the majority of patients with LUTS attributable to BPH at 3 ...Missing: cancer | Show results with:cancer
[26]
Updates on Preprocedural Evaluation and Patient Selection ... - NIH
Prostatic artery embolization (PAE) is a safe and effective treatment for benign prostatic hyperplasia. Patient evaluation is a critical and important part ...Missing: criteria | Show results with:criteria
[27]
Prostatic Artery Embolization (PAE) | Journal of Medical Insight - JOMI
Sep 1, 2023 · Contraindications to PAE include urethral or bladder issues that may affect treatment outcomes, such as bladder atony, neurological disorders ...Main Text · Overview · Special Acknowledgements<|control11|><|separator|>
[28]
Optimizing Prostatic Artery Embolization Outcomes
This should support wide adoption in the United States among practicing urologists whose patients have been asking for this therapy for years.
[29]
Contraindications to Prostatic Artery Embolization (PAE) - BackTable
Jun 23, 2018 · Dr. Isaacson strongly recommends against using PAE to treat vasculopaths - patients with a history of coagulation issues, lower extremity bypass grafts, ...
[30]
Prostate artery embolization: Before your procedure
How do you prepare for the procedure? · Do not eat or drink for 6 to 8 hours before the procedure. · Be sure you have someone to take you home. · Understand ...Missing: guidelines | Show results with:guidelines
[31]
Page Unavailable | SpringerLink
**Summary: Insufficient relevant content**
[32]
Prostatic Artery Embolization: Technical Pearls - PubMed Central - NIH
Preprocedure imaging can be performed to identify the PA before the date of the procedure. Computed tomography angiography (CTA) or magnetic resonance ...
[33]
Prostate Artery Embolization: Challenges, Tips, Tricks, and ...
Prostatic artery embolization (PAE) consists of blocking the arteries supplying the prostate to treat benign prostate hypertrophia (BPH).
[34]
Intentionally unilateral prostatic artery embolization - NIH
Sep 28, 2024 · Patients selected for IU-PAE should also fulfill at least one of the following criteria: Severe tortuosity or severe atheromatosis of the ...
[35]
Predicting early clinical success of prostate artery embolization ...
May 21, 2025 · This study aimed to assess the potential of DCE-MRI as a non-invasive tool for predicting PAE outcomes in BPH treatment and to identify specific perfusion ...<|control11|><|separator|>
[36]
Postembolization Syndrome after Prostatic Artery Embolization - NIH
Aug 31, 2020 · Postembolization syndrome (PES) is the most common side effect of vascular embolization of solid organs.
[37]
Prostate Artery Embolization - PMC - PubMed Central - NIH
Prostatic arterial embolization (PAE) is safe and effective, demonstrating high rates of technical success, improved urinary flow rates, and QoL.
[38]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9767765/
[39]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9865478/
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https://pmc.ncbi.nlm.nih.gov/articles/PMC11440269/
[41]
Comparison of Perioperative Outcomes for Prostate Artery ... - NIH
Aug 29, 2025 · One-year outcomes after prostate artery embolization versus laser enucleation: A network meta-analysis. BJUI Compass. 2024;5:189–206. doi ...
[42]
Systematic review and network meta‐analysis of re‐intervention ...
Apr 10, 2024 · The highest rate of re-intervention at 12 months was for PAE at 0.080% (95% CI 0.032–0.129; P = 0.001), followed by UroLift 0.048% (95% CI 0.018 ...
[43]
A Comparative Systematic Review and Meta-Analysis of 4 Different ...
PVP demonstrated the largest improvements in IPSS and QOL, followed by PAE. Compared with WV and PUL, PAE showed the greatest improvement in all HRQOL scores.<|separator|>
[44]
Benign Prostatic Hyperplasia (BPH) Guideline
The goal of this revised guideline is to provide a useful reference on the effective evidence-based surgical management of male lower urinary tract symptoms ...Using Aua Guidelines · Ipss Versus Aua-Si · Sexual Dysfunction And...
[45]
EAU Guidelines on the Management of Non-neurogenic Male LUTS
These EAU Guidelines offer practical evidence-based guidance on the assessment and treatment of men aged 40 years or older with various non-neurogenic ...Disease Management · References · Diagnostic Evaluation · MethodsMissing: artery embolization
[46]
Short- to Mid-term Safety and Efficacy of Prostatic Artery... - LWW
Oct 8, 2025 · Adverse events that occurred at any time during the 12-month follow-up were reported according to the Clavien−Dindo grading system. Results: A ...
[47]
Postembolization Syndrome after Prostatic Artery Embolization - MDPI
The aim of this review was to determine the incidence of PES and its individual components after prostatic artery embolization (PAE).<|control11|><|separator|>
[48]
A Review of Adverse Events Related to Prostatic Artery Embolization ...
Low adverse events rates have been reported following prostate artery embolization and may include dysuria, urinary infection, hematuria, hematospermia, acute ...
[49]
Safety Profile of Ambulatory Prostatic Artery Embolization after a ...
Embolization-related adverse events varied between 0 and 2.6%, access-site adverse events between 0 and 18%, and were all minor. There was no major event.
[50]
Radiation Safety in Prostatic Artery Embolization: A Review ... - MDPI
As a complex, fluoroscopic-guided endovascular procedure, PAE necessitates a significant use of ionizing radiation, raising important safety considerations ...Missing: irradiated | Show results with:irradiated
[51]
Prostatic Artery Embolization: Influence of Cone-Beam Computed ...
Mar 3, 2021 · We found an ED of 25.82 mSv for group A and 39.84 mSv for group B, which is within the range reported in the recent literature. Compared with a ...
[52]
Radiation Safety in Prostatic Artery Embolization: A Review of ...
Sep 22, 2025 · As a complex, fluoroscopic-guided endovascular procedure, PAE necessitates a significant use of ionizing radiation, raising important safety ...
[53]
Radiation Exposure During Prostatic Artery Embolisation
We found an ED of 25.82 mSv for group A and 39.84 mSv for group B, which is within the range reported in the recent literature. Compared with a standard ...<|control11|><|separator|>
[54]
Virtual Injection Software Reduces Radiation Exposure and ... - NIH
The use of VIS during PAE performed under CBCT can lead to a substantial reduction in patient radiation exposure and operative time.
[55]
AI and Interventional Radiology: A Narrative Review of ... - MDPI
... prostatic artery embolization is a promising treatment for benign prostatic hyperplasia. ... AI-driven collimation algorithms reduce radiation exposure and ...