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Spectinomycin

Spectinomycin is an aminocyclitol antibiotic produced by the soil bacterium Streptomyces spectabilis, characterized by its tricyclic structure and molecular formula C₁₄H₂₄N₂O₇.^[1] It functions as a bacteriostatic agent primarily active against gram-negative bacteria, including susceptible strains of Neisseria gonorrhoeae, by binding to the 30S subunit of the bacterial ribosome and inhibiting protein synthesis through blockade of the translocation step in translation.^[2] Discovered in 1961 and first described in scientific literature that year, spectinomycin was developed as an alternative treatment for gonorrhea, particularly for patients allergic to penicillin or in regions with emerging resistance.^[3] Spectinomycin was indicated for the treatment of uncomplicated gonococcal infections, such as urethritis and proctitis in males and cervicitis and proctitis in females caused by susceptible N. gonorrhoeae, but is no longer available for human use in the United States (discontinued in 2006).^[1] Administered as an intramuscular injection, the standard adult dose was 2 grams as a single dose, though 4 grams divided into two sites may be used in areas of high antibiotic resistance; it achieves peak serum concentrations of approximately 100 mcg/mL within one hour post-injection and exhibits minimal protein binding in plasma.^[2] Unlike beta-lactam antibiotics, spectinomycin shows no cross-resistance with penicillin against gonococci, making it valuable for specific resistance scenarios, though it does not cover syphilis and may mask its symptoms, necessitating follow-up serologic testing.^[2] Beyond human medicine, spectinomycin has applications in veterinary practice, where it is used to treat respiratory diseases in poultry and bovine respiratory disease complex in cattle, often formulated as spectinomycin sulfate for oral or injectable administration.^[4] Its spectrum is limited compared to broad-spectrum aminoglycosides, with activity primarily against certain gram-negative pathogens and reduced efficacy against many gram-positive bacteria due to intrinsic resistance mechanisms like efflux pumps.^[5] Resistance to spectinomycin, primarily mediated by mutations in ribosomal components such as 16S rRNA and ribosomal protein S5, has been reported globally since the 1970s, particularly in N. gonorrhoeae, influencing its role as a second-line option in modern treatment guidelines where available.^[6]^[7]

Chemistry and Classification

Structure and Properties

Spectinomycin has the molecular formula C₁₄H₂₄N₂O₇ and a molecular weight of 332.35 g/mol.^[8] The molecule possesses an aminocyclitol core characterized by a decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one ring system, featuring hydroxyl groups at positions 4a, 7, and 9, a methyl group at position 2, and methylamino groups at positions 6 and 8, with specific stereochemistry (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS). This tricyclic structure can be visualized in standard chemical diagrams of the compound.^[8] In its pure form, spectinomycin appears as a white to off-white crystalline powder. It is freely soluble in water (approximately 150 mg/mL), slightly soluble in alcohols such as methanol and ethanol, and insoluble in nonpolar solvents like chloroform. The melting point ranges from 184°C to 194°C, with decomposition occurring around 190°C. Aqueous solutions of the free base exhibit a basic pH, typically around 10.5–11.0 at concentrations of 10 mg/mL, though the pharmaceutically relevant salt form adjusts this value.^[8]^[1] The pharmaceutical preparation of spectinomycin is primarily the dihydrochloride pentahydrate salt (C₁₄H₂₄N₂O₇·2HCl·5H₂O, molecular weight 495.35 g/mol), which maintains similar solubility properties but with a pH of 3.8–5.6 in 10 mg/mL aqueous solutions. This salt form enhances stability for clinical use.^[9]^[1] Spectinomycin is sensitive to light, heat, and moisture, which can lead to degradation via hydrolysis or oxidation, forming inactive products such as actinamine derivatives. It should be stored in airtight containers at temperatures below 25°C, protected from direct light and humidity to preserve potency.^[10]

Classification

Spectinomycin is classified as an aminocyclitol antibiotic, a group characterized by a central aminocyclitol core, such as an inositol ring, without the glycosidic linkages typical of aminoglycosides.^[11] Despite structural similarities to aminoglycosides, spectinomycin lacks amino sugars and glycosidic bonds, placing it outside that class.^[1] This distinction contributes to its generally bacteriostatic mechanism of action against most bacteria, though it is bactericidal against susceptible strains of Neisseria gonorrhoeae, in contrast to the bactericidal effects of most aminoglycosides.^[12]^[13] Within the aminocyclitol family, spectinomycin is closely related to compounds like actinospectacin, which is an alternative name for the drug itself, and shares the broader category with other agents that target bacterial protein synthesis through aminocyclitol scaffolds.^[14] Unlike true aminoglycosides, such as streptomycin or gentamicin, spectinomycin's classification emphasizes its unique profile as a non-glycosylated aminocyclitol with limited overlap in pharmacological behavior.^[15] Spectinomycin exhibits a targeted antibacterial spectrum, primarily effective against Gram-negative bacteria, including Neisseria gonorrhoeae, with only moderate activity against Gram-positive organisms and minimal impact on anaerobes.^[1] This selective activity limits its broad-spectrum utility compared to many aminoglycosides.^[16] The World Health Organization includes spectinomycin on its Model List of Essential Medicines as an aminocyclitol for specific indications, underscoring its role in treating certain infections where other options are unsuitable.^[17]

Pharmacology

Medical Uses

Spectinomycin is indicated for the treatment of uncomplicated gonorrheal urethritis and proctitis in males, as well as cervicitis and proctitis in females, caused by susceptible strains of Neisseria gonorrhoeae, particularly in patients with hypersensitivity to beta-lactam antibiotics such as penicillin or cephalosporins. The standard regimen involves a single intramuscular injection of 2 grams, administered deep into the upper outer quadrant of the gluteal muscle, which achieves cure rates exceeding 90% for urogenital and anorectal infections. However, it demonstrates reduced efficacy against pharyngeal gonorrhea, with success rates below 60% in some studies, limiting its use in that context. Due to its unavailability in the US, spectinomycin is not part of current CDC treatment recommendations as of 2025; ceftriaxone 500 mg IM is the preferred regimen for uncomplicated gonorrhea, with gentamicin 240 mg IM plus azithromycin 2 g orally as the alternative for cephalosporin-allergic patients.^[18] In addition to its primary role, spectinomycin has a limited application in treating urethritis associated with Chlamydia trachomatis, where it shows modest in vitro activity but is not recommended as monotherapy due to suboptimal clinical outcomes; it is occasionally used in combination regimens for co-infections. For Mycoplasma genitalium infections, spectinomycin plays a niche role in managing refractory cases of urethritis, particularly those resistant to macrolides, with case reports documenting successful eradication following extended intramuscular dosing over 7 days.^[19] Animal studies show no evidence of teratogenicity or embryocidal effects, and spectinomycin may be used for treating gonorrhea in pregnant patients when cephalosporins are contraindicated.^[1] In veterinary medicine, spectinomycin is widely used to address respiratory and enteric bacterial infections in livestock, including pigs and poultry, targeting pathogens such as Pasteurella species and Mycoplasma species like Mycoplasma gallisepticum and Mycoplasma synoviae; it is formulated as oral premixes for administration in feed or water, or as injectables for acute cases in cattle and swine.^[4] Human use remains constrained by commercial unavailability in the United States since 2006.^[20]

Pharmacodynamics

Spectinomycin binds specifically to the 30S ribosomal subunit of susceptible bacteria, interacting with helix 34 (H34) of the 16S rRNA at residues such as G1064 and C1192, as well as the S5 protein. This interaction sterically hinders the swiveling of the small subunit's head domain and blocks the attachment of elongation factor G (EF-G), thereby preventing the translocation of peptidyl-tRNA from the A-site to the P-site during the elongation cycle of protein synthesis.^[5]^[21]^[22] The antibiotic's action results in bactericidal inhibition of bacterial protein synthesis against Neisseria gonorrhoeae, halting elongation without causing mRNA misreading or codon misrecognition, in contrast to the error-inducing effects of typical aminoglycosides. As an aminocyclitol, spectinomycin reversibly occupies its binding site, allowing resumption of translation upon drug removal. Its activity is concentration-dependent, with higher concentrations enhancing the rate and extent of inhibition.^[13]^[23]^[24]^[25] Spectinomycin exhibits potent activity against Neisseria gonorrhoeae, with minimum inhibitory concentrations (MICs) typically ranging from 8 to 16 μg/mL for susceptible strains. It shows moderate to limited efficacy against other Gram-negative bacteria, such as those in the Enterobacteriaceae family, due to intrinsic resistance mechanisms like efflux. Unlike some protein synthesis inhibitors, spectinomycin lacks a significant post-antibiotic effect, meaning bacterial regrowth resumes promptly after drug concentrations fall below inhibitory levels.^[1]^[26]^[27]

Pharmacokinetics

Spectinomycin is administered exclusively via intramuscular injection, as it exhibits poor oral bioavailability due to limited absorption from the gastrointestinal tract.^[28] Following intramuscular administration of a 2 g dose, the drug is rapidly absorbed, attaining peak plasma concentrations of approximately 100 μg/mL within 1 hour.^[29] The apparent volume of distribution is limited at approximately 0.2 L/kg, reflecting restricted tissue penetration, and spectinomycin shows poor entry into the cerebrospinal fluid.^[30] It achieves high concentrations in the urine, where up to 80% of an administered dose is recovered unchanged.^[30] Spectinomycin undergoes minimal hepatic metabolism and is primarily eliminated via renal excretion through glomerular filtration, consistent with its lack of significant plasma protein binding.^[28] The plasma elimination half-life ranges from 1.2 to 2.8 hours in individuals with normal renal function, with prolongation to 4.7–29 hours observed in renal impairment, necessitating dosage adjustments in such patients.^[31]

Biosynthesis

Producing Organisms

Spectinomycin is primarily produced by the soil-dwelling actinomycete Streptomyces spectabilis, a filamentous bacterium first isolated from soil samples in the mid-20th century. This species, characterized by its spore-forming, mesophilic nature and aerial mycelium formation, naturally synthesizes spectinomycin as a secondary metabolite, likely for ecological defense in soil environments.^[32]^[33] Related Streptomyces species also serve as producers, including S. flavopersicus and S. hygroscopicus var. sagamiensis, which harbor similar biosynthetic capabilities and have been utilized in various production strains. These organisms share the actinomycete lineage, thriving in terrestrial habitats where they contribute to antibiotic diversity in microbial communities.^[33]^[34] The genetic basis for spectinomycin production resides in a dedicated biosynthetic gene cluster within the Streptomyces genome, spanning approximately 17 kb and comprising genes such as spcM for methylation steps and others encoding synthase enzymes essential for assembling the aminocyclitol structure. This cluster has been sequenced and heterologously expressed in host strains to confirm its role.^[35]^[36] For industrial-scale production, Streptomyces strains are cultivated via submerged fermentation in large bioreactors, employing nutrient media with glucose as the primary carbon source to support high-yield growth. Process optimization, including strain engineering through genetic manipulation of the biosynthetic cluster, has significantly enhanced titers, enabling efficient recovery of spectinomycin from fermentation broths.^[34]^[37]^[33]

Biosynthetic Pathway

The biosynthetic pathway of spectinomycin proceeds through a branched route involving the independent assembly of the actinamine (aminocyclitol) moiety and the actinospectose sugar moiety, followed by their glycosylation and a final oxidative cyclization to form the characteristic dioxane bridge. This process is encoded by the spe/spc gene cluster in producing streptomycetes and encompasses more than 20 enzymatic steps, primarily involving oxidoreductases, aminotransferases, and transferases.^[35] The actinamine branch initiates from the central metabolite D-glucose-6-phosphate, which is converted to myo-inositol-1-phosphate by myo-inositol-1-phosphate synthase, an enzyme ubiquitous in bacteria for inositol production. Dephosphorylation of myo-inositol-1-phosphate by the phosphatase SpcA yields free myo-inositol, which undergoes C2 oxidation by the NAD+-dependent dehydrogenase SpcB to produce L-myo-inosose. Transamination at this carbonyl by the PLP-dependent aminotransferase SpcS2 introduces an amino group, forming L-myo-inosamine. A second iteration of oxidation (SpcB) and transamination (SpcS2) at C6 generates 2-epi-streptamine, the core cyclitol structure. N-methylation of the amino groups at what become N1 and N3 positions is then catalyzed by the SAM-dependent methyltransferase SpcM, completing actinamine.^[38]^[39] Parallel to this, the actinospectose branch derives from dTDP-D-glucose, a activated sugar donor. The 4,6-dehydratase SpcE removes water across C4 and C6 to form dTDP-4-keto-6-deoxy-D-glucose. Subsequent transamination at C4 by SpcS1 yields dTDP-4-amino-4,6-dideoxy-D-glucose. Further transformations, including epimerization at C3 (potentially by SpcH, a proposed epimerase) and reduction, produce dTDP-actinospectose, the modified deoxyhexose required for attachment. These steps mirror elements of desosamine sugar biosynthesis but are tailored by spectinomycin-specific enzymes.^[39]^[40] Glycosylation unites the moieties via the glycosyltransferase SpcG, which transfers actinospectose from dTDP-actinospectose to the C9 hydroxyl of actinamine, forming (2′R,3′S)-tetrahydrospectinomycin, a linear pseudodisaccharide intermediate. The pathway culminates in dioxane ring formation through dehydrogenation at the C2′ alcohol by the radical S-adenosylmethionine (SAM) enzyme SpeY, a twitch-domain protein that generates a 5′-deoxyadenosyl radical for hydrogen abstraction. This creates a C2′ ketone, enabling non-enzymatic hemiacetal cyclization between the ketone and the C4′ hydroxyl, followed by dehydration to establish the fused pyrano[2′,3′:4,5] ring system of spectinomycin. Additional accessory enzymes in the cluster, such as SpcD (proposed lyase) and SpecJ (O-methyltransferase for potential C6 or C4′ modifications), fine-tune late-stage adjustments, though their precise roles await full validation.^[40]^[39]

Adverse Effects and Resistance

Side Effects

Spectinomycin administration is generally well-tolerated, with most adverse effects being mild and transient. Common side effects include pain or soreness at the injection site, urticaria, pruritus, nausea, chills, fever, dizziness, headache, and insomnia.^[2] Rare adverse reactions include anaphylaxis or anaphylactoid responses, which require immediate medical intervention such as epinephrine, corticosteroids, and airway management.^[2] Unlike aminoglycosides, spectinomycin does not cause ototoxicity or nephrotoxicity, as evidenced by the absence of consistent renal function impairment in clinical studies.^[2]^[41] In pregnancy, spectinomycin is classified as FDA category B, with no teratogenic or embryocidal effects observed in animal studies at doses up to 1600 mg/kg/day; it may be used if clearly needed, particularly in penicillin-allergic patients.^[2]^[42] For breastfeeding, excretion into human milk is unknown, but caution is advised due to potential risks, with minimal expected transfer based on its pharmacokinetic profile.^[2] No routine laboratory monitoring is required, as side effects typically resolve spontaneously without intervention.^[2]

Drug Resistance

Bacterial resistance to spectinomycin arises primarily through enzymatic modification of the drug or alterations to its ribosomal target site. The most common enzymatic mechanism involves adenylylation at the 9-position of spectinomycin's cyclohexane ring, catalyzed by the aminoglycoside nucleotidyltransferase ANT(9)-Ia (also known as SpcN or AAD(9)). This enzyme, encoded by the plasmid- or transposon-borne ant(9)-Ia gene, is prevalent in Gram-positive bacteria such as Staphylococcus aureus and Enterococcus species, as well as some Gram-negative pathogens.^[43]^[11] The structural basis of this inactivation has been elucidated through crystallographic studies showing ANT(9)-Ia binding spectinomycin and ATP in its active site.^[11] Target-site resistance occurs via mutations in the 16S rRNA of the 30S ribosomal subunit, particularly in helix 34, which disrupts spectinomycin's binding and its inhibition of translocation during protein synthesis. In Neisseria gonorrhoeae, key mutations include G1064C and C1054A in this helix, conferring high-level resistance.^[44] Additional resistance can stem from mutations in the rpsE gene encoding ribosomal protein S5, which alters the 30S subunit conformation and reduces drug affinity, as observed in pathogens like Pasteurella multocida.^[7] These ribosomal changes are often chromosomal and can lead to fitness costs, such as slower growth rates in the absence of the antibiotic.^[7] Prevalence of spectinomycin resistance varies by pathogen and geography, remaining relatively low globally but with concerning trends in specific contexts. In N. gonorrhoeae, a major clinical target, resistance rates are approximately 0.3% worldwide as of 2024 based on data from over 235,000 isolates, though higher localized rates (up to several percent) have been reported in regions like the Western Pacific.^[45] As of 2025, resistance is considered widespread in some genomic profiles of N. gonorrhoeae, with rising minimum inhibitory concentrations (MICs) raising concerns about diminishing efficacy.^[46] Resistance is emerging in Mycoplasma genitalium, where spectinomycin serves as a salvage therapy for macrolide- and fluoroquinolone-resistant strains, with treatment failures indicating potential spread of ribosomal mutations.^[47] In Streptococcus suis, a zoonotic pathogen, resistance exceeds 80% in some European isolates, driven by both enzymatic and target modifications.^[48] Cross-resistance between spectinomycin and other antibiotic classes is limited due to its unique binding site on the ribosome, distinct from aminoglycosides like streptomycin, though some overlap exists with the bifunctional enzyme AAD(3") conferring resistance to both.^[49] Veterinary overuse of spectinomycin in livestock for respiratory and enteric infections in species like pigs and poultry has facilitated the dissemination of ant(9)-Ia-carrying plasmids, contributing to zoonotic transfer of resistance to human pathogens.^[50] To address these challenges, combination therapies pairing spectinomycin with agents like ceftriaxone are employed to suppress resistance emergence in N. gonorrhoeae.^[51] Recent developments include second-generation spectinomycin analogs, such as N-ethylene aminomethyl derivatives, which evade efflux pumps in Mycobacterium abscessus and demonstrate potent activity in mouse infection models.^[52]^[53]

History and Availability

Discovery and Development

Spectinomycin was discovered in 1961 by researchers at the Upjohn Company (now part of Pfizer) during a screening of soil microorganisms for novel antibiotics. The compound, initially named actinospectacin, was isolated from the actinomycete bacterium Streptomyces spectabilis through fermentation processes, revealing its broad-spectrum activity against Gram-negative bacteria.^[54] This discovery marked a significant advancement in addressing bacterial infections resistant to existing therapies, as early characterizations highlighted its unique aminocyclitol structure and protein synthesis inhibition mechanism.^[33] Development of spectinomycin progressed rapidly in the 1960s, with preclinical and clinical trials focusing on its potential for treating sexually transmitted infections. It received U.S. Food and Drug Administration (FDA) approval in 1971 under the brand name Trobicin for the treatment of uncomplicated gonorrhea caused by Neisseria gonorrhoeae, particularly in cases where penicillin resistance was a concern. Early clinical studies demonstrated high efficacy rates, with cure rates exceeding 90% in male patients and no observed cross-resistance with beta-lactam antibiotics, establishing spectinomycin as a valuable alternative in the pre-quinolone era.^[9]^[55]^[29] Key events in spectinomycin's history include a major supply disruption in 2001, when Pharmacia Corporation (the then-parent of Upjohn) discontinued U.S. production due to low sales volume, resulting in a nationwide shortage as remaining inventories expired by mid-year. This event underscored vulnerabilities in antibiotic supply chains for niche therapies. Following the full discontinuation of human formulations in the U.S. by 2006, spectinomycin saw a resurgence in veterinary applications post-2010, with increased usage in livestock production, such as in swine and poultry for controlling respiratory and enteric infections, driven by regulatory shifts and sustained demand in animal health.^[56]^[57] Research on spectinomycin's production advanced in the 1990s with the cloning of biosynthetic and resistance genes from producer strains like Streptomyces flavopersicus, enabling genetic insights into its aminocyclitol pathway and self-resistance mechanisms. More recently, between 2023 and 2025, studies have focused on overcoming resistance in nontuberculous mycobacteria (NTM), such as Mycobacterium abscessus, through the development of spectinomycin analogs. These efforts include N-ethylene aminomethyl spectinomycins (eAmSPCs) showing potent activity against efflux-mediated resistance and 3',6'-disubstituted derivatives with enhanced antibacterial profiles against NTM pathogens, aiming to revive spectinomycin's utility in challenging infections.^[58]^[59]^[60]^[53]

Regulatory Status

Spectinomycin for human use was withdrawn from the United States market in November 2005 when Pfizer discontinued its distribution of the drug (Trobicin), leaving no domestic manufacturing or approved suppliers available thereafter.^[61] It remains unavailable for routine human prescription in the US, though limited personal importation may be permitted under FDA policies for unapproved medications in specific circumstances.^[62] Globally, spectinomycin is included on the World Health Organization's Model List of Essential Medicines (23rd List, 2023; updated 2025), recommended as a single-dose option in injectable form for certain bacterial infections where access is prioritized in resource-limited settings.^[63] In veterinary medicine, spectinomycin is widely approved for use in animal health across major regions, including the European Union under EMA guidelines for antimicrobial residues and the United States via FDA tolerances for residues in poultry and swine (21 CFR § 556.600).^[64] In China, it is authorized as part of the veterinary medicine portfolio to address respiratory infections in livestock, contributing to market expansion.^[65] The global veterinary spectinomycin market is projected to grow steadily through 2031, driven by rising demand for treatments in livestock amid increasing animal populations and respiratory disease prevalence in regions like Europe and Asia.^[66] Spectinomycin is not classified as a controlled substance under US DEA schedules, allowing standard pharmaceutical handling without narcotic restrictions.^[67] However, imports into the US face FDA oversight, with restrictions on unapproved human formulations requiring compliance with personal importation policies or veterinary-specific approvals to prevent residue risks in food animals.^[68] Recent trends from 2023 to 2025 highlight veterinary sector expansion for spectinomycin, aligned with global antibiotic stewardship efforts to reserve critical drugs for animal use while curbing human overuse.^[69] As a low-cost generic antibiotic, spectinomycin benefits from widespread availability in developing markets, though global supply chains have faced disruptions from raw material volatility and trade tariffs, particularly affecting fermentation-based production inputs from Asia.^[70] These challenges have occasionally led to shortages in veterinary supplies, underscoring the need for diversified manufacturing to ensure access.^[71]

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Discovery and biological properties. Antibiot Chemother (Northfield). 1961 Feb:11:118-22. Authors. D J MASON, A DIETZ, R M SMITH. PMID: 13767811. No abstract ...Missing: et al. Upjohn
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Spectinomycin Hydrochloride (Trobicin) in the Treatment of Gonorrhea
We conclude that spectinomycin HC1 (Trobicin; Upjohn) is a useful drug for the treatment of acute gonorrhea in males.
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Notice to Readers: Shortage of Spectinomycin - CDC
Jun 8, 2001 · Patients in this category include: 1) pregnant women with documented cephalosporin allergies (fluoroquinolones are contraindicated in pregnancy); ...
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Current status and trends in antimicrobial use in food animals in ...
Dec 8, 2023 · Moreover, penicillin, spectinomycin, and tilmicosin use increased, while ampicillin and ofloxacin use decreased. AGP use decreased by 6,012.74 ...
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Development of 2nd generation aminomethyl spectinomycins that ...
Jan 2, 2024 · The primary limitations of the eAmSPCs are low oral bioavailability which is favored for NTM therapies, and the maximum tolerated doses are ...
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Mab2780c, a TetV-like efflux pump, confers high-level ...
Mycobacterium abscessus is highly resistant to spectinomycin (SPC) thereby making it unavailable for therapeutic use. Sublethal exposure to SPC strongly ...
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Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins
Jun 18, 2024 · SPC has a limited spectrum of activity due to innate resistance mechanisms in most organisms, largely mediated by efflux, and plasmid-encoded ...
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Notice to Readers: Discontinuation of Spectinomycin - CDC
Apr 7, 2006 · In January 2006, CDC learned that Pfizer, Inc. (New York, New York) had discontinued US distribution of spectinomycin (Trobicin ® ) in November 2005.
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Importing Medications Into USA: What's Allowed and What Gets ...
Apr 5, 2025 · The FDA allows the import of unapproved medications under limited circumstances through its Personal Importation Policy.
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Spectinomycin - Electronic Essential Medicines List
Chlamydia trachomatis: first-choice therapy is azithromycin or doxycycline. • Trichomonas vaginalis: first-choice therapy is metronidazole. • Syphilis: first- ...<|separator|>
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21 CFR § 556.600 - Spectinomycin. - Law.Cornell.Edu
§ 556.600 Spectinomycin. (a) Acceptable daily intake (ADI). The ADI for total residue of spectinomycin is 25 µg/kg of body weight per day.Missing: import | Show results with:import
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China Veterinary Medicine Market Size | Industry Report 2030
The China veterinary medicine market size was estimated at USD 3.12 billion in 2023 and is projected to grow at a CAGR of 8.2% from 2024 to 2030.Missing: Spectinomycin EU
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Spectinomycin Industry Research Report 2025 - MarketResearch.com
Oct 20, 2025 · North American market for Spectinomycin is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the ...
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21 CFR Part 1313 - Importation of Listed Chemicals - eCFR
Chemical importations into the United States for immediate transfer/transshipment outside the United States must comply with the procedures set forth in § ...
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Import Alert 66-66 - accessdata.fda.gov
Note: The revision of this Import Alert (IA) dated 10/10/2024 updates the reason for alert, guidance section including agency contacts, and PAC.
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First report on EU-wide sales and use of antimicrobials in animals
Mar 31, 2025 · The findings are presented in the first European Sales and Use of Antimicrobials for Veterinary Medicine (ESUAvet) annual surveillance report.Missing: Spectinomycin China market 2031
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Spectinomycin CAS 1695 77 8 Market Report 2025 (Global Edition)
Restricted Use in Human Medicine: The market size of spectinomycin is limited because it is primarily used to treat gonorrhea. Creation of Newer Antibiotics ...
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Shortage of essential antimicrobials: a major challenge to global ...
Nov 2, 2021 · In this review, we have mapped common drivers for antimicrobial shortages and propose strategies for rethinking the regulation, supply and ...Missing: Spectinomycin | Show results with:Spectinomycin