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Vagotomy

Vagotomy is a surgical procedure that involves severing branches of the vagus nerve, which innervates the stomach, to decrease gastric acid production and thereby treat conditions like peptic ulcer disease (PUD).^[1] This intervention disrupts the nerve's parasympathetic signals that stimulate acid secretion from parietal cells in the gastric mucosa, historically serving as a cornerstone for managing refractory or complicated ulcers before the advent of modern pharmacotherapy.^[2] Developed in the early 20th century following Ivan Pavlov's physiological studies on the vagus nerve's role in gastric secretion, vagotomy gained prominence in the 1940s as the gold standard for PUD treatment, particularly truncal vagotomy introduced by Lester Dragstedt.^[3] Over time, refinements led to selective vagotomy, which spares hepatic and celiac branches while targeting gastric innervation, and highly selective (or parietal cell) vagotomy, which precisely denervates acid-producing regions of the stomach fundus and body while preserving antral and pyloric function to maintain normal gastric emptying.^[2] These procedures are typically performed laparoscopically or via open surgery, often combined with a drainage procedure like pyloroplasty to prevent gastric outlet obstruction or with antrectomy for more definitive acid control.^[1] Indicated primarily for complicated PUD—such as bleeding, perforation, or obstruction—in patients unresponsive to medications like proton pump inhibitors or Helicobacter pylori eradication, vagotomy has largely fallen out of routine use since the late 1970s due to effective nonsurgical options.^[4] Despite this, it remains relevant in select cases of recurrent ulceration or Zollinger-Ellison syndrome. Common complications include dumping syndrome, postvagotomy diarrhea, delayed gastric emptying, and increased risk of gallstones, with outcomes varying by type: truncal procedures offer low recurrence (under 5%) but higher side effect rates, while highly selective variants reduce morbidity at the cost of slightly higher re-ulceration (up to 15%).^[2] Long-term success depends on adjunctive therapies, underscoring vagotomy's evolution from a primary intervention to a targeted, last-resort option in gastrointestinal surgery.^[1]

Anatomy and Physiology

Vagus Nerve Overview

The vagus nerve, designated as cranial nerve X, is the longest cranial nerve in the human body and functions as a mixed nerve containing both sensory (afferent) and motor (efferent) fibers, with approximately 80% of its fibers being afferent and 20% efferent. It primarily provides parasympathetic innervation to the thoracic and abdominal viscera, including the heart, lungs, esophagus, stomach, small intestine, and proximal colon, playing a crucial role in regulating visceral functions such as digestion and cardiac rhythm. Emerging from the medulla oblongata in the brainstem, the vagus nerve exits the skull via the jugular foramen and descends through the neck alongside the carotid artery and internal jugular vein.^[5] In its thoracic course, the right and left vagus nerves contribute to the esophageal plexus surrounding the esophagus, where their fibers intermingle before reforming into the anterior and posterior vagal trunks just above the diaphragm. These trunks then penetrate the abdomen by passing through the esophageal hiatus in the diaphragm, allowing continued innervation of abdominal organs. The anterior vagal trunk, derived mainly from the left vagus, lies on the anterior surface of the esophagus and stomach, while the posterior trunk, primarily from the right vagus, courses along the posterior aspect. Relevant to gastric innervation, the anterior trunk gives rise to the hepatic branch, which supplies the liver, gallbladder, and duodenum, and contributes to the anterior gastric branches along the lesser curvature of the stomach. The posterior trunk provides the celiac branch, which extends to the celiac plexus for broader foregut and midgut innervation, and the posterior gastric branches that target the greater curvature and posterior stomach wall. The vagus nerve provides the majority of the parasympathetic outflow to the upper gastrointestinal tract (foregut and midgut up to the splenic flexure), interfacing with the enteric nervous system to modulate gut motility and secretion, including a key role in stimulating gastric acid production.^[6]

Gastric Innervation and Acid Secretion

The vagus nerve provides parasympathetic innervation to the stomach, playing a pivotal role in regulating gastric acid secretion and motility through both afferent and efferent pathways. Efferent fibers originate from the dorsal motor nucleus of the vagus (DMV) and synapse in the enteric nervous system, releasing acetylcholine (ACh) that stimulates muscarinic receptors on target cells. This activation initiates the cephalic phase of gastric secretion, triggered by sensory inputs such as sight, smell, or thought of food, accounting for approximately 30% of total acid output. Vagal efferents also enhance antral motility and coordinate the gastric phase by promoting gastrin release from G cells in the antrum.^[7]^[2] Vagal stimulation directly influences acid production by targeting parietal cells in the gastric fundus and corpus, where ACh binds to M3 muscarinic receptors, activating the H+,K+-ATPase proton pump to secrete hydrochloric acid. Indirectly, vagal fibers stimulate enterochromaffin-like (ECL) cells via ACh and pituitary adenylate cyclase-activating polypeptide (PACAP), prompting histamine release that binds H2 receptors on parietal cells to amplify acid secretion. Gastrin, released from antral G cells under vagal influence, synergizes with these pathways by activating cholecystokinin-2 receptors (CCK2R) on both ECL and parietal cells, further potentiating the response; this hormonal-neural interplay contributes to 90% of postprandial acid output. Innervation density varies regionally: the fundus receives denser vagal input to support high parietal cell activity in oxyntic glands, while the antrum has sparser innervation focused on G cells and motility regulation. Afferent vagal fibers, comprising about 80% of the nerve's gastric component and originating from nodose ganglia, sense gastric distension and nutrient presence via calcitonin gene-related peptide (CGRP), relaying signals to the nucleus tractus solitarius (NTS) for feedback modulation of efferent activity.^[8]^[7]^[8] Vagotomy interrupts these pathways by denervating the fundic glands, substantially reducing both basal and stimulated acid secretion. Basal acid output typically decreases by 50-70%, while stimulated output (e.g., via histamine, gastrin, or sham feeding) is reduced by 60-80%, depending on the procedure's extent and completeness. This denervation spares antral G cell function in selective variants but profoundly impairs cephalic and neural components of secretion, highlighting the vagus nerve's dominant role in acid homeostasis. Efferent disruption also diminishes gastric motility, as seen in reduced antral contractions post-vagotomy.^[7]^[9]^[10]

Types of Vagotomy

Truncal Vagotomy

Truncal vagotomy involves the surgical division of both the anterior and posterior vagal trunks, typically 2 to 4 cm proximal to the gastroesophageal junction at the esophageal hiatus, to achieve broad denervation of abdominal viscera. This procedure targets the main trunks of the vagus nerve as they pass through the diaphragmatic hiatus, resulting in complete interruption of parasympathetic innervation to the stomach, pylorus, biliary tree, pancreas, and proximal small intestine below the diaphragm.^[2]^[11] The operation is performed via an intra-abdominal approach, either open or laparoscopically, beginning with mobilization of the distal esophagus to expose the vagal trunks. The anterior trunk is usually identified along the anterior esophageal wall, while the posterior trunk lies in the retroesophageal space and may require careful dissection to locate. Both trunks are then mobilized, clipped, and divided, with segments often sent for histologic confirmation to ensure completeness. Historically introduced by Lester Dragstedt in 1943 as a treatment for peptic ulcer disease, truncal vagotomy was the standard vagal denervation technique through the mid-20th century and was frequently combined with a drainage procedure, such as pyloroplasty, to mitigate postoperative gastric atony.^[2]^[12]^[13] Physiologically, truncal vagotomy profoundly inhibits gastric acid secretion by eliminating the vagally mediated cephalic phase, which accounts for about 30% of total acid output, and markedly reducing the gastric phase, contributing up to 60% of acid production, for an overall reduction of 70-90% in stimulated acid secretion. This denervation also disrupts coordinated gastric motility, leading to accelerated emptying of liquids but delayed solid emptying due to loss of pyloric sphincter control, and impairs exocrine pancreatic function through ablation of vagal fibers to the pancreas. The non-selective nature of this procedure affects all subdiaphragmatic vagal branches, including hepatic and celiac divisions, resulting in the broadest scope of autonomic disruption among vagotomy types and consequently the highest potential for motility-related sequelae.^[2]^[14] Intraoperatively, identification of the vagal trunks relies on direct visualization after esophageal retraction, with adjuncts like a liver retractor to expose the hiatus and occasional use of nerve stimulators to elicit confirmatory gastric contractions or pH changes, ensuring no accessory trunks are overlooked. This comprehensive denervation approach, while effective for acid suppression, underscores its role as a more extensive intervention compared to targeted vagal procedures.^[2]^[11]

Selective Vagotomy

Selective vagotomy is a surgical procedure that involves the division of only the gastric branches of the vagus nerve, including the pyloric branches, while sparing the hepatic and celiac divisions to preserve innervation to the liver, gallbladder, pancreas, and intestines.^[15] This targeted approach denervates the entire stomach, including the antrum and pylorus, distinguishing it from truncal vagotomy, which interrupts the main vagal trunks and affects broader abdominal viscera.^[2] Unlike highly selective vagotomy, which focuses on acid-secreting parietal cells and spares antral function, selective vagotomy requires a concomitant drainage procedure, such as pyloroplasty, to mitigate gastric emptying issues.^[15] The procedure typically employs a laparotomy approach, involving meticulous dissection along the distal esophagus to mobilize and encircle the main vagal trunks, preserving the anterior hepatic and posterior celiac branches.^[11] Surgeons identify and divide the anterior and posterior gastric nerves of Latarjet below these branch points, ensuring complete gastric denervation without compromising non-gastric functions. Historically performed through open laparotomy, this technique allows for precise isolation of the gastric branches, though it demands greater surgical skill compared to truncal vagotomy.^[11] Physiologically, selective vagotomy reduces basal and stimulated gastric acid secretion by 60-80%, comparable to truncal vagotomy, effectively controlling peptic ulcer disease by diminishing acid output from the stomach.^[16] It maintains biliary and pancreatic exocrine function due to preserved hepatic and celiac innervation, and better safeguards intestinal motility than truncal procedures, reducing the risk of severe post-operative diarrhea.^[15] However, because it denervates the pylorus, gastric stasis can occur, necessitating drainage in most cases to facilitate emptying.^[15] Introduced in the mid-20th century as an advancement over truncal vagotomy, selective vagotomy aimed to minimize side effects such as dumping syndrome and postvagotomy diarrhea by limiting denervation to the stomach.^[15] With careful execution, it achieves low ulcer recurrence rates of around 2%, though incomplete dissection can lead to higher rates up to 40%.^[15] Despite these benefits, prospective studies have shown no significant reduction in side effects compared to truncal vagotomy with drainage, contributing to its diminished use in favor of less invasive options like highly selective vagotomy or medical therapies.^[15]

Highly Selective Vagotomy

Highly selective vagotomy, also known as parietal cell vagotomy or proximal gastric vagotomy, is a surgical procedure that selectively divides the vagal nerve branches innervating the acid-secreting parietal cells in the fundus and body of the stomach, while sparing the innervation to the antrum, pylorus, and the "crow's foot" nerves that maintain gastric motility.^[2] This precision targets the intramural nerves along the lesser curvature of the stomach, denervating only the regions responsible for acid production without affecting the antropyloroduodenal mechanism.^[17] Developed in the late 1960s and refined in the 1970s as a refinement of earlier vagotomy techniques, it was introduced clinically by Holle and Hart in 1967 to minimize the side effects associated with broader denervation procedures.^[18] The procedure involves meticulous dissection of the anterior and posterior vagal trunks' gastric branches, typically requiring magnification or microscopic assistance to identify and preserve fine nerve fibers essential for gastric function, which contributes to its higher technical difficulty and longer operative time compared to less selective vagotomies.^[2] Unlike truncal or selective vagotomy, no drainage procedure such as pyloroplasty is routinely needed, as pyloric sphincter function remains intact.^[17] This approach was designed specifically to interrupt parasympathetic stimulation of acid secretion while preserving receptive relaxation of the fundus and antral grinding motility.^[18] Physiologically, highly selective vagotomy reduces basal acid output by more than 75% and stimulated acid secretion by over 50%, achieving a 50-70% overall decrease in acid production that effectively controls hypersecretion in peptic ulcer disease.^[17] It has minimal impact on gastric emptying, with solid food transit remaining normal and only slight acceleration of liquid emptying, due to the preserved vagal supply to the antrum and pylorus.^[2] Long-term, it demonstrates the lowest rates of severe complications among vagotomy types, such as dumping syndrome or diarrhea, with ulcer recurrence rates of 5-15% over 5-10 years, reflecting its precision but also the challenge of complete denervation.^[18]

Surgical Procedure

Operative Techniques

Vagotomy can be performed via open laparotomy, laparoscopic, or minimally invasive approaches, with the choice depending on patient factors and surgeon expertise. In the open approach, an upper midline incision is made from the xiphoid process to above the umbilicus, allowing access to the peritoneal cavity, followed by placement of self-retaining retractors and a liver retractor to expose the gastroesophageal junction (GEJ).^[2] The esophagus is mobilized approximately 4-5 cm above the GEJ using a Penrose drain for circumferential dissection, facilitating access to the vagal trunks along the esophageal surface.^[2] Laparoscopic techniques involve insertion of 2-3 trocars (typically 10-mm and 5-mm), initial diagnostic laparoscopy to confirm anatomy, upward retraction of the liver, and traction on the stomach to expose the GEJ, often through division of the lesser omentum and phrenoesophageal ligament.^[19] Endoscopic approaches remain experimental and non-standard, primarily explored for vagus nerve targeting under ultrasound guidance but not routinely adopted for complete vagotomy.^[20] Intraoperative steps begin with identification of the vagal trunks, typically located 2-4 cm superior to the GEJ on the anterior and posterior esophageal surfaces. For truncal and selective vagotomies, the anterior trunk is identified first, mobilized for at least 2 cm, then clipped proximally and distally before division using cautery or sharp dissection; the posterior trunk is similarly located on the right lateral esophagus and divided.^[2] In highly selective vagotomy (also known as parietal cell vagotomy), the procedure targets only the gastric branches supplying the acid-secreting fundus and body, involving meticulous dissection along the vascular arcades of the lesser curvature—starting 5-7 cm proximal to the pylorus—to skeletonize the nerves while preserving crow's foot branches to the pylorus and antropyloric region.^[21] Branches are divided using clips, ligatures, or harmonic shears in laparoscopic cases, with resected tissues sent for pathological confirmation.^[19] Robotic assistance enhances visualization and dexterity for these dissections, particularly in highly selective procedures, allowing precise nerve isolation in refractory cases.^[12]^[22] Operative duration typically ranges from 1 to 3 hours, with laparoscopic truncal vagotomy averaging 115 minutes compared to 95 minutes for open procedures.^[19] Completeness is confirmed intraoperatively using pH testing—where gastric mucosal pH rises above 6 indicates successful denervation—or endoscopy with Congo red dye, which turns black below pH 3.0 if residual innervation persists, allowing immediate revision.^[23]^[24] Conversion from laparoscopic to open occurs in 3-10% of cases, often due to adhesions or anatomical challenges, though rates are lower with experienced teams.^[17]

Associated Interventions

Vagotomy, particularly truncal and selective variants, often disrupts normal gastric motility by denervating the pylorus and reducing receptive relaxation of the stomach fundus, leading to delayed gastric emptying and potential stasis of solids.^[2] To mitigate these effects and ensure adequate gastric outflow, surgical interventions such as drainage procedures are commonly performed concurrently. These adjuncts restore patency at the pyloroduodenal junction or bypass it, minimizing risks of obstruction while avoiding significant reflux of duodenal contents.^[25] The most frequent adjunct is pyloroplasty, which widens the pyloric sphincter to facilitate emptying. The Heineke-Mikulicz technique, involving a longitudinal incision across the pylorus closed transversely to double its diameter, is the standard method and is routinely paired with truncal or selective vagotomy to address hypomotility.^[26] Historically, such drainage procedures accompanied vagotomy in the majority of cases for peptic ulcer disease, as they were essential to prevent postoperative gastric retention.^[2] Antrectomy, the resection of the distal stomach including the antrum and pylorus, serves dual purposes: removal of ulcer-bearing tissue and provision of drainage, often combined with truncal vagotomy for more aggressive acid suppression in complicated cases.^[12] As an alternative drainage option, particularly when pyloric scarring precludes pyloroplasty, gastrojejunostomy creates a side-to-side anastomosis between the stomach and jejunum, bypassing the duodenum to promote emptying.^[25] In contemporary practice, highly selective vagotomy preserves innervation to the pylorus and antropyloric region, thereby maintaining physiologic emptying and obviating the need for drainage procedures in most patients.^[1] Laparoscopic approaches have further refined these interventions, enabling minimally invasive truncal vagotomy with pyloroplasty or gastrojejunostomy, which reduce recovery time and perioperative morbidity compared to open techniques.^[27]

Indications

Peptic Ulcer Disease

Vagotomy serves as a surgical intervention primarily for complicated peptic ulcer disease (PUD), particularly in cases of intractable duodenal or gastric ulcers that persist despite optimal medical management, including proton pump inhibitors (PPIs) and eradication of Helicobacter pylori infection.^[2] It is indicated for patients experiencing acute complications such as bleeding, perforation, or gastric outlet obstruction, where conservative treatments fail to control symptoms or prevent recurrence.^[4] In contemporary practice, vagotomy is rarely employed, reflecting the rarity of surgical needs due to advances in medical therapy, though it remains relevant for severe, refractory presentations. In emergency cases like perforation, vagotomy is selectively added only if medical therapy fails long-term, per current guidelines (as of 2025).^[28]^[29] A rare but notable indication for vagotomy arises in Zollinger-Ellison syndrome, a condition characterized by gastrin-secreting tumors leading to hyperacidity and refractory ulcers, where vagotomy adjunctively reduces acid secretion to facilitate medical control with agents like cimetidine.^[30] Patient selection emphasizes individuals with H. pylori-negative ulcers unrelated to nonsteroidal anti-inflammatory drug (NSAID) use, ensuring that surgical risks are justified only after exhaustive nonsurgical options.^[2] Preoperative evaluation typically includes endoscopy to confirm ulcer location and status, alongside manometry to assess gastric motility and outlet function, aiding in tailoring the procedure to avoid postoperative complications like delayed emptying.^[31]^[32] Outcomes of vagotomy in PUD demonstrate effective acid suppression, with highly selective vagotomy achieving approximately 80% reduction in basal acid secretion, contributing to overall success rates in symptom control and healing.^[33] Ulcer recurrence following highly selective vagotomy is generally low, at around 11.6% over five years, underscoring its durability in appropriately selected patients when combined with drainage procedures if needed.^[34] This physiological reduction in acid output directly addresses the hypersecretory state underlying PUD pathogenesis.^[2]

Refractory Cases and Alternatives

In cases of Zollinger-Ellison syndrome, characterized by gastrinoma-induced gastric acid hypersecretion, vagotomy has been employed to reduce acid output, even when tumors remain unresected. This intervention facilitates better control of hyperacidity when combined with acid-suppressing medications such as H2-receptor antagonists like cimetidine. Highly selective vagotomy, in particular, has been recommended for patients requiring high doses of these agents to minimize surgical risks while addressing refractory hypersecretion.^[30]^[35] For refractory acid-related disorders unresponsive to standard medical therapy, vagotomy serves as a surgical option in resource-limited settings where proton pump inhibitors (PPIs) are unavailable or ineffective. Such scenarios may arise in developing regions lacking consistent access to modern pharmacotherapy, prompting vagotomy as a definitive intervention to prevent ulcer complications.^[2] The widespread adoption of PPIs since the late 1980s has markedly diminished vagotomy's role, rendering it largely obsolete for most acid-peptic conditions due to the drugs' superior efficacy and tolerability. In contemporary bariatric surgery, vagotomy is seldom incorporated, reflecting its marginal utility amid advanced alternatives.^[36]^[2]^[37]

Complications

Perioperative Risks

Vagotomy, whether performed as truncal, selective, or highly selective, carries perioperative risks inherent to upper abdominal surgery, including bleeding, infection, and injury to adjacent structures such as the esophagus or stomach. Intraoperative bleeding can occur due to vascular injury during dissection of the vagal trunks near the esophageal hiatus, and may be exacerbated by coagulopathy or emergency settings.^[2] Surgical site infections may arise from contamination during open procedures or wound healing issues, though laparoscopic approaches reduce this incidence by minimizing incision size.^[2] Esophageal or gastric leaks and injuries can result from inadvertent thermal or mechanical damage during vagus nerve division, potentially leading to mediastinitis or peritonitis if undetected.^[2] General anesthesia complications, such as cardiovascular instability or respiratory events, occur at rates comparable to other major intra-abdominal surgeries, with overall elective mortality remaining below 1%.^[38] Laparoscopic vagotomy mitigates some wound-related risks like infection but introduces specific hazards, including pneumothorax due to diaphragmatic injury or carbon dioxide insufflation tracking into the pleural space during hiatal dissection.^[39] Modern laparoscopic approaches, particularly for highly selective vagotomy, are associated with low mortality (<0.5%) and major complication rates under 5%.^[40] To minimize incomplete vagotomy, which could necessitate reoperation, intraoperative vagal testing—such as the insulin hypoglycemia test, pH probing of gastric mucosa, or neural stimulation—is employed to confirm denervation completeness before closure.^[41] Postoperative management typically involves nasogastric tube decompression for 24-48 hours to prevent gastric distension and facilitate early detection of leaks, with tube removal guided by resolution of ileus and adequate gastric emptying.^[11] Close monitoring in the perioperative period focuses on vital signs to detect hemodynamic instability from bleeding or sepsis, alongside serial assessments of abdominal exam for signs of peritonitis.^[2] Gastric acid output can be evaluated postoperatively using pH probes or aspirates if concerns for incomplete vagotomy arise, ensuring timely intervention.^[42] These protocols, informed by standardized surgical guidelines, contribute to low overall morbidity in elective vagotomy.

Long-term Sequelae

One of the primary long-term sequelae following vagotomy is dumping syndrome, characterized by rapid gastric emptying that leads to gastrointestinal and vasomotor symptoms such as nausea, bloating, diarrhea, and palpitations after meals. This condition affects 10-20% of patients who undergo truncal or selective vagotomy, primarily due to the loss of vagal innervation that normally regulates gastric motility and emptying.^[43] In contrast, highly selective vagotomy, which preserves innervation to the gastric fundus and body, significantly reduces the incidence to less than 5%, minimizing disruption to normal digestive physiology.^[44] Postvagotomy diarrhea represents another enduring complication, occurring in up to 25% of cases after truncal vagotomy, often linked to altered small bowel motility and bile acid malabsorption resulting from vagal denervation. This can manifest as chronic loose stools, impacting daily life and nutritional status. Gastric atony, a delayed gastric emptying disorder, and recurrent ulcers are less common long-term, with atony more prevalent after truncal procedures due to impaired antral contractions. Additionally, there is a low risk of nutritional deficiencies, including vitamin B12 malabsorption due to reduced acid secretion and intrinsic factor output, though clinical deficiency is uncommon (less than 5%) and may necessitate monitoring or supplementation in select cases.^[45]^[46]^[47] Management of these sequelae emphasizes conservative approaches to preserve quality of life. Dietary modifications, such as frequent small meals low in simple carbohydrates and separated from fluids, effectively control dumping syndrome in most patients. For refractory cases, octreotide—a somatostatin analog—slows gastric emptying and alleviates symptoms in up to 90% of affected individuals.^[48] Postvagotomy diarrhea often responds to fiber supplementation or bile acid binders, while reoperations for severe complications like persistent atony or recurrent ulcers are rare, occurring in only 1-3% of cases.^[49] Overall outcomes for vagotomy in peptic ulcer disease show 80-90% patient satisfaction, with sustained ulcer control and acceptable symptom resolution years post-procedure. Vagotomy has been experimentally used for obesity treatment historically but was largely abandoned due to significant side effects like severe dumping and diarrhea outweighing modest weight loss benefits.

History and Current Role

Early Development

The concept of vagotomy as a surgical intervention to interrupt vagal innervation and reduce gastric acid secretion originated in the early 20th century, building on physiological studies linking the vagus nerve to gastric function. French surgeon Alfred Latarjet first proposed and performed vagotomy in 1922, reporting outcomes in 24 patients, including six with peptic ulcers, though the procedure saw limited adoption due to incomplete understanding of its effects and high risks at the time.^[50]^[51] The modern clinical application of vagotomy began in the 1940s, pioneered by American surgeon Lester R. Dragstedt, who recognized its potential for treating duodenal ulcers driven by hypersecretion. In 1943, Dragstedt performed the first truncal vagotomy using a transthoracic approach to sever the vagus nerves above the diaphragm, reporting successful acid suppression and ulcer healing in initial cases without the need for gastric resection.^[51]^[52]^[13] This innovation marked a shift toward nerve-denervating procedures over more radical resections, with early reports demonstrating high success rates, including approximately 90% healing of marginal ulcers when combined with adequate drainage.^[3] To address post-vagotomy gastric atony and retention, Dragstedt soon combined truncal vagotomy with pyloroplasty or gastroenterostomy, enhancing stomach emptying while preserving more anatomy than subtotal gastrectomy. This pairing, introduced in the mid-1940s, became a standard for intractable duodenal ulcers, with operative mortality under 1% and low recurrence in verified complete denervation cases.^[2] Vagotomy gained widespread acceptance in the 1950s and 1960s as the predominant surgical treatment for peptic ulcer disease in the United States, where it was performed alongside antrectomy as a gold standard approach, reflecting significant clinical volume and refinement.^[53] Milestones included the introduction of selective vagotomy in the 1960s, which preserved hepatic and celiac branches to minimize side effects like diarrhea, and highly selective (parietal cell) vagotomy in 1973 by David Johnston, targeting only acid-secreting parietal cell branches while sparing antral innervation.^[3]^[53]

Decline and Modern Applications

The introduction of H2-receptor antagonists in the 1970s marked the beginning of vagotomy's decline, as these medications effectively controlled gastric acid hypersecretion and healed peptic ulcers without surgery.^[12] This pharmacological advancement reduced the reliance on operative acid reduction, with vagotomy procedures dropping sharply as medical therapy became the standard for most cases of peptic ulcer disease (PUD).^[14] The development of proton pump inhibitors (PPIs) in the late 1980s and 1990s further accelerated this trend, providing superior acid suppression and ulcer healing rates, leading to a dramatic overall decrease in surgical interventions for PUD. Concurrently, the identification of Helicobacter pylori as the primary etiology of many ulcers in the 1980s, followed by effective antibiotic eradication regimens, shifted the paradigm toward curative nonsurgical treatment, rendering vagotomy obsolete for routine PUD management.^[54] In contemporary practice, vagotomy is performed infrequently in the United States, primarily due to these medical alternatives.^[2] A laparoscopic revival in the 1990s introduced minimally invasive techniques, such as laparoscopic highly selective vagotomy, which aimed to reduce perioperative morbidity while preserving gastric motility; however, even these approaches have seen limited adoption amid ongoing pharmacological dominance.^[55] Investigational applications have explored vagal nerve modulation for obesity, exemplified by the vBloc device, an implantable vagal blocking system approved by the FDA in 2015. Clinical trials in the 2010s demonstrated approximately 24% excess weight loss at 18 months in moderate to severe obesity cases, with a favorable safety profile, though the device was effectively withdrawn from widespread clinical use in the early 2020s due to reimbursement challenges and limited adoption.^[56]^[57] Today, vagotomy retains a niche role in emergency settings for complicated PUD, such as bleeding or perforated ulcers unresponsive to endoscopic hemostasis, particularly in hemodynamically unstable patients or resource-limited environments where advanced medical therapies like PPIs or endoscopy may be unavailable.^[58] It is also rarely incorporated into revisional bariatric surgery to address refractory marginal ulcers following procedures like Roux-en-Y gastric bypass, often combined with gastrojejunostomy revision to mitigate acid-related complications.^[59] Looking ahead, endoscopic vagotomy techniques are emerging in early 2020s feasibility trials, leveraging endoscopic ultrasound-guided nerve targeting to potentially offer a less invasive option for select acid-related disorders, though these remain investigational as of 2025.^[60] Pharmacological supersession continues to limit vagotomy's scope, while alternative vagus nerve neuromodulation strategies are being evaluated for obesity and metabolic conditions as nonablative complements to traditional surgery.^[61]

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Effect of vagotomy in Zollinger-Ellison syndrome - PubMed
We conclude that vagotomy facilitates control of acid secretion in Zollinger-Ellison syndrome, and we recommend vagotomy and cimetidine rather than total ...Missing: indication | Show results with:indication
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[PDF] The role of endoscopy in the management of patients with peptic ...
This guideline is an update of a previous ASGE document2 and defines the role of upper GI endoscopy in the diagno- sis and management of patients with known or ...
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Effect of Highly Selective Vagotomy on Gastric Motor Activity of ...
Jan 27, 2009 · The effect of highly selective vagotomy on the gastric emptying time of a food-barium meal and antral myoelectrical and manometrical ...
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Proximal gastric vagotomy - SpringerLink
PGV reduces both acid and pepsin secretion. Basal acid secretion is reduced by 80%, while maximal acid response to pentagastrin or to a meal is reduced by 50–60 ...Missing: percentage | Show results with:percentage
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Recurrences 1 to 10 years after highly selective vagotomy ... - PubMed
The 5- and 10-year cumulative recurrence rates were 11.6% and 16.8%, respectively. These figures were not related to age, sex, duration of ulcer disease, or ...
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Highly selective vagotomy should be considered in those patients who require high doses of Cimetidine or ranitidine. Total gastrectomy should be reserved for ...
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Vagotomy as a treatment for morbid obesity - PubMed
Weight decreases of 20 to 30 kg (range, 2 to 64 kg) have been observed so far. Impaired gastric emptying alone does not seem to account for the decreases.Missing: historical studies 1970s
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Vagotomy as a Treatment for Morbid Obesity - ScienceDirect
Truncal vagotomy has been attempted as a treatment for morbid obesity in 13 patients. The observed weight losses of 20 to 30 kg do not seem to be due to ...Missing: historical studies 1970s complications
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Bioelectric neuromodulation for gastrointestinal disorders - Nature
Nov 2, 2018 · Pulses of high-frequency current applied to the vagus nerve have been used to block signalling from the stomach to the brain to reduce appetite ...
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Aug 4, 2023 · Vagal nerve devices also allow reversibly targeting of the vagus nerve at various anatomical levels and functions maximising metabolic effects ...
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Acid-reducing vagotomy is associated with reduced risk of ... - NIH
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Vagotomy and drainage for elective treatment of peptic ulcers
In this group, there was one operative mortality, an incidence of 0.4 per cent; 99.7 per cent were successfully observed for periods extending up to 25 years.Missing: perioperative bleeding infection
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Two patients developed subcutaneous emphysema and pneumomediastinum during laparoscopic vagotomy. One of the patients also had a pneumothorax which produced ...
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Highly selective vagotomy with intraoperative acid secretive test of ...
This technique of highly selective vagotomy with an intraoperative acid secretion test to determine completeness of vagal section is designed to demonstrate ...
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It is suggested that intraoperative pH testing improves the likelihood of a complete vagotomy, the test is also useful to plot precisely the antral-body ...
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Dumping Syndrome - StatPearls - NCBI Bookshelf - NIH
In patients who have undergone gastric surgery, an estimated 20% to 50% of patients have symptoms of Dumping syndrome. Patients develop severe symptoms ...
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Vagotomy without diarrhoea - PubMed
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Six of the 71 patients (8 percent) who had truncal vagotomy had atony, whereas only 1 of the 30 patients (3 percent) with proximal gastric vagotomy had atony ( ...
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[PDF] Dumping Syndrome - University of Virginia School of Medicine
Significant dumping has been reported in 6%–14% of patients who have undergone truncal vagotomy with drainage.
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Results of vagotomy and pyloroplasty for peptic ulcer - Surgery
A satisfactory result was achieved in 85.5 percent of the patients. Unsatisfactory results were obtained in 14.5 percent of the patients. This figure includes ...
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Lester R. Dragstedt and his role in the evolution of therapeutic ...
The operation he proposed was a vagotomy. The first patient to receive a Dragstedt vagotomy was a 35-year-old man who had a bleeding duodenal ulcer ...
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A STUDY OF VAGOTOMY | JAMA Surgery
In 1910 Pavlov4 demonstrated that intact vagus innervation was necessary for ... (b) Latarjet, A.: Resection des nerfs de l'estomac , Bull. Acad. de ...
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How Helicobacter pylori Changed the Life of Surgeons
Apr 4, 2003 · ... decline in vagotomies between 1993 ... Helicobacter pylori by single shot antibiotic treatment in patients undergoing proximal vagotomy.
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Jun 28, 2015 · The vBloc device was developed for patients with moderate to severe obesity, as an alternative to conventional weight loss surgery and does ...
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the narrowing role for vagotomy in the treatment of peptic ulcer ...
Conclusions: The role of vagotomy in the management of PUD has a rich history but predated pharmacologic control of acid and understanding of the role of ...
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Truncal Vagotomy and Gastrojejunostomy Revision for Treatment of ...
Oct 1, 2025 · This can be chronic, or acute with perforation or hemorrhage. Laparoscopic truncal vagotomy with revision of the gastrojejunal anastomosis is ...
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Endoscopic truncal vagotomy. Exploring the fourth space. A ...
This study demonstrates technical feasibility of (1) EUS-guided vagus nerve identification and targeting using a fine-needle aspiration as needed, ...Missing: trials 2020s
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The Safety and Efficacy of vBloc Therapy Delivered by the Maestro ...
The study evaluated the safety and efficacy of the vBloc Therapy delivered by the Maestro Rechargeable System compared to a sham control for the treatment ...Missing: 2010s | Show results with:2010s<|control11|><|separator|>