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Woodruff's plexus

Woodruff's plexus is a venous plexus consisting of thin-walled veins located on the posterior lateral wall of the inferior meatus in the nasal cavity.^[1] First described in 1949 by American otolaryngologist George H. Woodruff as the "naso-nasopharyngeal plexus" in the context of cardiovascular-related epistaxis, it was named after him and initially proposed as a site of severe posterior nosebleeds.^[2] Anatomical studies using cadaveric microdissection and histological analysis have confirmed its venous nature, distinguishing it from the more anterior arterial Kiesselbach's plexus and resolving earlier misconceptions that portrayed it as arterial due to its proximity to branches of the sphenopalatine artery.^[1]^[3] Clinically, Woodruff's plexus is significant for its potential role in posterior epistaxis, which often fails to respond to anterior nasal packing and may require posterior packing, endoscopic cauterization, or ligation of supplying vessels.^[4] Despite its vascular prominence, modern reviews emphasize that while it contributes to bleeding in some instances, the exact etiology of posterior epistaxis is multifactorial, involving hypertension, coagulopathies, and local trauma rather than the plexus alone as a primary source.^[3] Its identification remains crucial for targeted interventions in otorhinolaryngology, particularly in managing refractory nosebleeds in adults.

Anatomy

Location

Woodruff's plexus is situated on the posterior lateral wall of the inferior meatus in the nasal cavity.^[5] This vascular network lies below the posterior end of the inferior turbinate (concha).^[6] It occupies a submucosal position on the lateral nasal wall at the posterior aspect of the inferior turbinate.^[7] The plexus extends posteriorly to the junction of the nasal cavity and nasopharynx.^[8] It maintains close proximity to the choana, the posterior nasal aperture.^[9] The structure is surrounded by a thin mucosa that covers the plexus, providing minimal structural support.^[1] This mucosal layer is relatively devoid of other tissues, emphasizing the plexus's superficial positioning within the nasal architecture.^[10]

Composition

Woodruff's plexus is primarily a venous plexus formed by anastomoses of veins that drain the posterior nasal cavity.^[1] This network lies embedded in the submucosa of the lateral nasal wall.^[5] The region containing Woodruff's plexus is supplied by branches of the sphenopalatine artery (terminal branch of the maxillary artery) and the ascending pharyngeal artery.^[7] Histological studies confirm the venous predominance of the plexus, revealing large, thin-walled veins with minimal surrounding muscle or fibrous tissue, situated within a thin mucosa.^[1] While both arteries and veins are present in the submucosa, the venous components form the primary network, as supported by anatomical dissections.^[5] The plexus exhibits individual anatomical variations in its extent and configuration, though it generally spans a small area posterior to the inferior turbinate.^[5]

History

Discovery

Woodruff's plexus was first described in 1949 by George H. Woodruff, an American otolaryngologist based in Joliet, Illinois.^[2] In his seminal paper published in The Laryngoscope, Woodruff detailed the structure while investigating the causes of severe posterior epistaxis, particularly in the context of cardiovascular disease. His observations stemmed from surgical explorations of bleeding sites in the posterior nasal cavity, where he identified a prominent vascular network vulnerable to rupture.^[11] Woodruff characterized this network as a "naso-nasopharyngeal plexus," comprising dilated, thin-walled veins—primarily venous but involving arterial elements—that extended from the posterior end of the inferior turbinate along the lateral nasal wall to the nasopharynx. These findings were based on direct intraoperative views in patients with hypertension and arteriosclerosis, conditions that he linked to the plexus's fragility and propensity for profuse bleeding resistant to conventional anterior packing.^[11] He emphasized how elevated blood pressure and vascular degeneration in older individuals exacerbated rupture risks in this anatomically strategic location. This discovery occurred amid post-World War II advancements in otolaryngology, including improved surgical instrumentation and early refinements in nasal endoscopy that facilitated precise visualization and exploration of posterior nasal structures.^[12] Subsequent studies have confirmed Woodruff's initial observations, though with refinements to its anatomical delineation.^[11]

Evolving Understanding

Following the initial description of Woodruff's plexus in 1949, subsequent anatomical research has refined its characterization, particularly regarding its vascular composition. A 2008 cadaveric study involving microdissection of 21 nasal specimens, along with histological analysis and vascular injection techniques, confirmed the structure as a superficial venous plexus composed of large, thin-walled veins embedded in sparse mucosa with minimal supporting tissue. This finding directly challenged earlier assumptions that portrayed it as an arterial network, providing the first detailed histological evidence of its venous nature.^[1] A 2021 systematic review of 154 publications, including 40 primary studies, further illuminated ongoing debates in the literature, revealing persistent discrepancies in how the plexus is described. While only two anatomical dissection studies—both affirming its venous composition—exist, 23 reports erroneously attribute arterial origins to it, often linking this to clinical observations of posterior epistaxis without supporting evidence. The review emphasized that modern sources predominantly recognize its venous structure, attributing outdated arterial references to historical misconceptions rather than empirical data.^[5] Since the 1990s, advancements in imaging have contributed to better understanding of posterior nasal vascularity, though direct visualization of the venous plexus remains challenging. Techniques such as CT angiography, first applied to epistaxis evaluation around that time, have been instrumental in identifying arterial sources of refractory bleeding in the posterior nasal cavity, providing context for the plexus's role amid surrounding vasculature.^[13] Endoscopic investigations have increasingly questioned the traditional emphasis on Woodruff's plexus as a primary site of posterior epistaxis. A 2007 prospective study of 50 adults with idiopathic posterior nosebleeds found that while a plexus-like structure was occasionally visible, it was never the active bleeding source; instead, hemorrhage originated more frequently from adjacent areas on the anterior nasal septum or lateral wall near the sphenopalatine artery.^[14] As of 2023, reviews continue to support its venous composition and secondary role in epistaxis.^[15]

Clinical Significance

Role in Epistaxis

Woodruff's plexus is a vascular network implicated in posterior epistaxis, accounting for approximately 10-20% of posterior epistaxis cases, which themselves represent 5-10% of all epistaxis episodes due to its location on the posterior lateral nasal wall.^[4]^[16] This posterior positioning distinguishes it from more common anterior bleeds, contributing to the relative infrequency of involvement in overall nosebleed incidents, where anterior sources predominate.^[17] However, contemporary research highlights that posterior epistaxis is multifactorial, with Woodruff's plexus contributing in select cases alongside arterial sources and systemic factors.^[3] Posterior epistaxis originating from Woodruff's plexus is more prevalent in adults over 50 years of age and is frequently associated with systemic conditions such as hypertension, arteriosclerosis, and anticoagulation therapy, which exacerbate vascular fragility in this demographic.^[16] These factors increase the likelihood of hemorrhage in the posterior nasal cavity, often leading to more challenging clinical presentations compared to anterior bleeds.^[15] Bleeding from the thin-walled veins of Woodruff's plexus can result in profuse hemorrhage, often manifesting as bilateral bleeding or post-nasal drip into the pharynx.^[16] This venous predominance in Woodruff's plexus contrasts with arterial sources and contributes to the severity of the bleed, heightening risks such as airway compromise.^[16] In differentiation, anterior epistaxis, primarily from Kiesselbach's area on the nasal septum, constitutes 90-95% of cases and is generally easier to visualize and manage, whereas Woodruff's plexus involvement represents a portion of posterior events, often requiring specialized intervention due to its inaccessible site.^[16]

Diagnostic Considerations

Diagnosis of bleeding from Woodruff's plexus during epistaxis evaluation primarily relies on direct visualization techniques to identify the posterior nasal cavity as the source. Nasal endoscopy, using either rigid (such as 0° or 30° 4 mm endoscopes) or flexible fiberoptic scopes, is the cornerstone method, allowing precise localization of the bleeding site in the posterior regions that are inaccessible by anterior rhinoscopy.^[18]^[19] This approach is particularly valuable in posterior epistaxis cases, where Woodruff's plexus may be identified, for example in one small study accounting for 25% of endoscopically examined patients with confirmed posterior sources.^[18] Key endoscopic signs include active bleeding or clot formation in the posterior end of the inferior meatus on the lateral nasal wall, typically situated below the posterior aspect of the inferior turbinate.^[4] Patient history may support this, such as reports of blood being spat out while sitting upright, distinguishing it from anterior sources.^[18] These findings confirm involvement of the venous plexus without requiring invasive measures initially. Imaging modalities like computed tomography (CT) or magnetic resonance imaging (MRI) are not first-line for acute diagnosis but may be employed in recurrent or refractory cases to map vascular structures and exclude underlying pathology.^[13] Specifically, CT can assess for arterial involvement or anomalies in suspected vascular epistaxis, though its utility is limited for the primarily venous Woodruff's plexus unless complications like pseudoaneurysms are suspected.^[16] Differential diagnosis is crucial to differentiate Woodruff's plexus bleeding from other posterior sources, such as branches of the sphenopalatine artery, which are more arterial and often require distinct interventions.^[18] Additionally, nasopharyngeal tumors or other neoplasms must be ruled out through endoscopy and, if indicated, imaging, as they can mimic plexus-related epistaxis in presentation.^[18]

Management

Non-Surgical Approaches

Non-surgical approaches to managing epistaxis arising from Woodruff's plexus primarily involve conservative measures to achieve hemostasis, focusing on tamponade, local vasoconstriction, and targeted cautery, often guided by nasal endoscopy for precise identification of the posterior bleeding site.^[16] These methods are typically first-line interventions for acute bleeds, aiming to avoid more invasive procedures in the majority of cases.^[20] First-line treatment includes anterior and posterior nasal packing to tamponade the posterior bleeding site, commonly associated with Woodruff's plexus on the postero-lateral nasal wall.^[20] Anterior packing uses materials such as nasal tampons or ribbon gauze coated with petrolatum or bismuth iodoform paraffin paste to compress the nasal vestibule and anterior septum.^[16] For posterior packing, a Foley catheter (12-14 Fr) is advanced into the nasopharynx, inflated with 5-10 mL of sterile saline or water to secure the posterior position, followed by anterior packing to prevent dislodgement; alternatively, double-balloon catheters provide simultaneous anterior and posterior tamponade, with the posterior balloon inflated to 5-10 mL and the anterior to 15-30 mL.^[20] Packing is left in place for 48-72 hours, with patients monitored for complications such as hypoxia or infection, and prophylactic antibiotics are sometimes administered.^[16] Posterior packing achieves hemostasis in approximately 70% of cases with balloon devices, though overall success rates for packing in posterior epistaxis range from 70-90% depending on the technique and patient factors.^[20] Topical vasoconstrictors, such as oxymetazoline 0.05% spray, are applied bilaterally after clot removal to reduce mucosal blood flow and facilitate visualization during endoscopy.^[16] Cautery follows if a bleeding point is identified, with silver nitrate sticks (75%) applied topically for accessible sites, exerting firm pressure for 5-10 seconds to achieve chemical coagulation; however, this is limited to one side to prevent septal perforation.^[16] For posterior sites like Woodruff's plexus, bipolar electrocautery under endoscopic guidance (using 0° or 30° scopes) is preferred, allowing precise ablation of the vessel with suction to clear blood; this minimally invasive approach controls bleeding in about 70% of localized cases.^[18] Management of underlying factors is essential to support hemostasis and prevent recurrence. Hypertension, a common exacerbating factor, should be controlled to a systolic blood pressure below 120 mm Hg using antihypertensives, as elevated pressure prolongs bleeding duration.^[16] In patients on anticoagulants or antiplatelets, reversal agents (e.g., vitamin K or prothrombin complex concentrate for warfarin) or withholding the medication is recommended if clinically appropriate, balancing bleeding risk with thrombotic concerns.^[16]

Surgical Techniques

Surgical techniques are employed for managing refractory epistaxis arising from Woodruff's plexus when non-invasive measures, such as nasal packing, fail to achieve hemostasis.^[16] These procedures target the vascular supply to the plexus, which is primarily derived from the sphenopalatine artery, a branch of the maxillary artery.^[16] Endoscopic sphenopalatine artery ligation (ESPAL) is a minimally invasive surgical intervention performed via a transnasal approach to interrupt the arterial blood flow to the plexus. Under general anesthesia, a 0° or 30° endoscope is used to access the middle meatus, where the mucosa over the sphenopalatine foramen is incised to expose and clip or coagulate the sphenopalatine artery, often with bipolar electrocautery if clipping is not feasible.^[21] This technique, first described endoscopically in the late 1990s, has become the standard for persistent posterior epistaxis, with success rates of 85-90% in preventing rebleeding.^[21] Potential complications include palatal numbness from greater palatine nerve injury and temporary nasal crusting, though major adverse events are rare.^[21]^[18] Endovascular embolization offers an alternative radiological approach for occluding the feeding arteries to Woodruff's plexus in cases unresponsive to packing.^[22] Performed under fluoroscopic guidance, an interventional radiologist accesses the femoral artery and advances a catheter to the internal maxillary or sphenopalatine artery, where embolic agents such as polyvinyl alcohol particles (150-350 μm) or absorbable Gelfoam are deployed to achieve proximal occlusion; coils are reserved for aneurysmal variants.^[22] This method is indicated for severe, recurrent bleeds requiring urgent control, yielding initial hemostasis in about 90% of patients, though rebleeding occurs in 10-20% of cases.^[22] Complications, affecting up to 20% of patients, may include facial or palatal numbness, dry nose syndrome due to mucosal ischemia, and transient jaw claudication; severe risks like stroke or blindness are infrequent at around 2%.^[22] Direct endoscopic cautery or laser ablation provides targeted treatment for identifiable bleeding foci within the plexus itself.^[18] Using a rigid endoscope under local anesthesia, the site—often along the posterior nasal wall or inferior meatus—is infiltrated with anesthetic, then cauterized with suction cautery, bipolar coagulation, or Nd:YAG laser to seal vessels while minimizing thermal spread.^[18] Indicated for localized refractory posterior epistaxis, this approach succeeds in controlling hemorrhage without packing in approximately 75% of cases, reducing the need for more invasive ligation.^[18] Adverse effects are generally mild, including transient nasal dryness or crusting, with low risk of septal perforation if applied unilaterally.^[18]

References

[1]
Woodruff's plexus - PubMed
Woodruff's plexus is a venous plexus in the posterior part of the inferior meatus. Significance: This is the first time Woodruff's plexus has been properly ...Missing: definition | Show results with:definition
[2]
Cardiovascular epistaxis and the naso-nasopharyngeal plexus
Cardiovascular epistaxis and the naso-nasopharyngeal plexus. Laryngoscope. 1949 Nov;59(11):1238-47. doi: 10.1288/00005537-194911000-00003. Author. G H WOODRUFF.Missing: posterior | Show results with:posterior
[3]
https://doi.org/10.1007/s00276-021-02852-0
[4]
Woodruff plexus | Radiology Reference Article | Radiopaedia.org
May 1, 2019 · Woodruff plexus is a venous plexus located in the posterior end of the inferior meatus on the lateral wall of the nasal cavity.
[5]
Woodruff's plexus-arterial or venous? - PubMed
Oct 29, 2021 · Woodruff's plexus is a vascular network located on the posterior lateral wall of the inferior meatus of the nasal cavity and it is generally considered to be ...Missing: George H.
[6]
Anatomy, Head and Neck, Nasal Concha | Point of Care - StatPearls
Jun 22, 2024 · The Woodruff plexus is located on the lateral nasal wall at the posterior aspect of the inferior turbinate. This submucosal network of veins ...
[7]
Anatomy, Head and Neck, Nasal Cavity - StatPearls - NCBI Bookshelf
This is the drainage site of the frontal, anterior ethmoid, and maxillary sinuses. Inferior Meatus: Located inferior to the inferior turbinate and superior to ...
[8]
Endoscopic view of a Posterior Nasal and Nasopharyngeal Vascular ...
toward the nasal floor, choana, and nasopharyngeal surface of the soft palate (figure, B). This area became known as Woodruff's area or Woodruff's plexus and.
[9]
Woodruff's plexus | Request PDF - ResearchGate
Aug 6, 2025 · Woodruff's plexus is a venous plexus in the posterior part of the inferior meatus. This is the first time Woodruff's plexus has been properly ...
[10]
Epistaxis | Iowa Head and Neck Protocols
Apr 26, 2017 · Woodruff's plexus: Confluence of vessels posterior to the middle turbinate; Formed from contributions of the: Sphenopalatine (from maxillary ...<|control11|><|separator|>
[11]
Woodruff's plexus | The Journal of Laryngology & Otology
Feb 21, 2008 · Woodruff's plexus has been described as an arterial plexus formed by the anastomosis of several branches, including the pharyngeal,Reference ...
[12]
Comprehensive understanding of vascular anatomy for ... - NIH
Posterior bleeding less commonly occurs at the posterior watershed area, known as the Woodruff plexus, which consists of the sphenopalatine and posterior ...
[13]
[PDF] 31Epistaxis - Thieme Connect
This plexus is formed by the anastomosis of the branches of the sphe- nopalatine and the ascending pharyngeal arteries. The sphenopalatine artery is the ...
[14]
A history of rhinology in North America - ScienceDirect
After World War II, however, there was a need for a society entirely devoted to rhinology, and in 1954 the American Rhinological Society was founded in ...
[15]
Radiological Diagnosis and Management of Epistaxis - PMC
Some investigators state that a venous plexus, called Woodruff's plexus, is a common source of bleeding in cases of posterior epistaxis. This plexus is ...Missing: 1990s | Show results with:1990s
[16]
Epistaxis - StatPearls - NCBI Bookshelf - NIH
Sep 12, 2022 · This is usually presumed due to bleeding from the Woodruff plexus, the rear, and fine terminal branches of the sphenopalatine and posterior ...Missing: overstated | Show results with:overstated
[17]
Epistaxis: A Common Problem - PMC - NIH
Of note, 2 anastomotic areas within the nose often provide a source of epistaxis. Woodruff area is located on the inferior aspect of the lateral nasal wall, ...
[18]
Posterior epistaxis management: review of the literature and ...
Nov 30, 2023 · Woodruff's plexus, another common bleeding site, is located on the posterior aspect of the lateral wall of the inferior meatus. Other key ...
[19]
Endoscopic Management of Posterior Epistaxis - PMC - NIH
Feb 25, 2011 · The various sites of bleeding in case of posterior epistaxis include Woodruff's plexus situated on the posterior aspect of the lateral wall ...Missing: overstated importance
[20]
Epistaxis - Symptoms, Causes, Images, and Treatment Options
Posterior epistaxis: Originates from the posterior nasal cavity, usually branches of sphenopalatine or from an area known as Woodruff's plexus (a confluence of ...
[21]
Posterior Epistaxis Nasal Pack - StatPearls - NCBI Bookshelf
A notable portion of posterior epistaxis arises in Woodruff's plexus on the postero-lateral wall of the nasal cavity, just posterior to the inferior turbinate.
[22]
Endoscopic Sphenopalatine Artery Ligation in Posterior Epistaxis
In this study, we aimed to present the results of 30 patients who underwent transnasal endoscopic sphenopalatine artery ligation (TESPAL) for posterior ...
[23]
Transcatheter Embolization in the Management of Epistaxis - PMC
Intractable epistaxis is generally posterior in origin and may require endoscopic cautery, posterior packing, surgical ligation, or embolization.Anatomical Considerations · Embolization Technique And... · Embolization: Results<|control11|><|separator|>