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Iodoform

Iodoform, also known as triiodomethane (CHI₃), is a pale yellow, crystalline organoiodine compound with a molecular weight of 393.73 g/mol, notable for its distinctive saffron-like odor and volatility.^[1] It appears as a bright yellow powder or crystals, melts at 119–122 °C, sublimes at 218 °C, and exhibits low solubility in water (<1 mg/mL) but good solubility in organic solvents like ethanol, ether, and chloroform.^[1] Discovered in 1822 by French chemist Georges Serullas through the reaction of iodine vapor with steam over red-hot coals, iodoform's antiseptic properties were identified in 1880, leading to its widespread adoption in medical practice during the late 19th and early 20th centuries. It gained prominence as a disinfectant due to its ability to slowly release free iodine, which denatures bacterial proteins and exhibits mild antimicrobial activity without significant irritation.^[2] Historically, iodoform served as a key antiseptic in surgical and dental applications, including wound dressings, cavity packing for conditions like dry socket, and formulations such as Whitehead's varnish (introduced in 1891) and bismuth iodoform paraffin paste (BIPP, developed in 1916 for World War I wound care).^[3] It promotes granulation tissue formation, destroys microbial toxins, and remains stable in oral fluids and blood, making it suitable for secondary wound healing in ulcers, cysts, and postoperative sites when mixed with agents like glycerine or eucalyptus oil.^[2] In chemistry, iodoform is central to the iodoform test, a qualitative reaction used to detect methyl ketones or alcohols that can be oxidized to methyl ketones, producing the characteristic yellow precipitate.^[1] Although its use has declined since the mid-20th century in favor of safer, more effective antiseptics due to potential toxicity—including skin/eye irritation, allergic reactions (1–12% incidence), and risks to the liver, kidneys, or fetus in pregnancy—iodoform persists in niche applications like ENT surgery, neurosurgery, oral/maxillofacial procedures, and veterinary disinfectants for lesions.^[1]^[3] It is synthesized industrially from acetone, sodium hypochlorite, potassium iodide, and sodium hydroxide, and is classified as harmful if swallowed or inhaled but non-carcinogenic.^[1]

Nomenclature and structure

Nomenclature

Iodoform is the retained trivial name for the organoiodine compound with the molecular formula CHI3.^[4] The term "iodoform" originates from the prefix "iodo-" denoting iodine combined with "-form," derived from "formyl," referring to the formyl group (HCO–), reflecting its historical association with formyl derivatives.^[5] This naming convention parallels the haloform series, which includes chloroform (retained name for trichloromethane, CHCl3), bromoform (retained name for tribromomethane, CHBr3), and iodoform as the trihalogenated methane analogs where chlorine, bromine, or iodine replaces hydrogen atoms.^[4] The preferred IUPAC name for CHI3 is triiodomethane, emphasizing the systematic substitution of three iodine atoms on a methane backbone.^[4] Other synonymous names include carbon triiodide and methyl triiodide, which highlight the carbon-iodine composition or the methyl group's implied structure.^[1] These alternative designations are used in various chemical contexts but do not supersede the retained or preferred IUPAC nomenclature for formal identification.^[6]

Molecular structure

Iodoform has the chemical formula \ce{CHI3}.^[1] The molecule features a central carbon atom covalently bonded to one hydrogen atom and three iodine atoms via single bonds. In its Lewis structure, the carbon atom serves as the central atom with four sigma bonds and no lone pairs, while each iodine atom possesses three lone pairs of electrons to satisfy the octet rule.^[1]^[7] The three-dimensional arrangement adopts a tetrahedral molecular geometry with C_{3v} point group symmetry, where the central carbon is at the tetrahedron's center, the hydrogen occupies one vertex, and the three iodine atoms occupy the remaining vertices.^[1]^[8] The C–I bond lengths are approximately 213 pm, and the H–C–I bond angle is about 109.5°, consistent with the idealized tetrahedral configuration.^[9]

Properties

Physical properties

Iodoform is a pale yellow to bright yellow crystalline solid or powder with a pungent, disagreeable odor often described as saffron-like.^[1]^[10]^[11] The compound exhibits noticeable volatility at room temperature due to its vapor pressure of approximately 0.04 mmHg, resulting in a detectable vapor.^[1]^[12] Key physical properties of iodoform under standard conditions are summarized below:

Property	Value
Molecular weight	393.73 g/mol
Melting point	119–122 °C
Boiling point	218 °C (sublimes)
Density	4.008 g/cm³ at 25 °C
Solubility in water	0.01 g/100 mL at room temperature
Solubility in organic solvents	Soluble in ethanol (7.8 g/100 mL), diethyl ether (13.6 g/100 mL), and chloroform

These properties reflect iodoform's high iodine content, which contributes to its characteristic yellow color.^[1]^[13]^[14]^[12]

Chemical properties

Iodoform exhibits good stability under normal ambient conditions, remaining unchanged at room temperature and pressure when protected from light. However, it decomposes upon heating above its melting point, releasing iodine vapor and forming hydrogen iodide gas along with carbon residues or trace hydrocarbons.^[1]^[14] Due to the relatively weak C-I bonds (bond dissociation energy approximately 234 kJ/mol), iodoform serves as a convenient source of iodide ions in various chemical processes. This bond weakness also renders it sensitive to strong bases and oxidizing agents, leading to potential cleavage or substitution under such conditions.^[1]^[14] The methine hydrogen atom in iodoform possesses moderate acidity, enabling deprotonation by strong bases to generate the corresponding carbanion. In infrared spectroscopy, iodoform displays characteristic C-I stretching vibrations between 500 and 600 cm⁻¹. Nuclear magnetic resonance spectroscopy reveals a distinctive singlet for the methine proton in the ¹H NMR spectrum at approximately δ 6.8–7.2 ppm (in CDCl₃), reflecting the deshielding effect of the iodine atoms.^[1]^[15]^[16]

Synthesis and occurrence

Synthetic methods

Iodoform is produced industrially via the haloform reaction using acetone as the substrate, with iodine generated in situ from potassium iodide and sodium hypochlorite in the presence of sodium hydroxide. This method allows for efficient large-scale production by controlled addition of reagents to avoid excess iodine.^[1] The primary laboratory synthesis of iodoform (CHI₃) utilizes the haloform reaction, involving the oxidative cleavage of methyl ketones or alcohols that can be oxidized to methyl ketones, such as acetone or ethanol, in the presence of iodine and a base like sodium hydroxide. For acetone, the reaction proceeds as follows:

\ce{CH3COCH3 + 3I2 + 4NaOH -> CHI3 + CH3COONa + 3NaI + 3H2O}

This process involves the sequential iodination of the methyl group followed by nucleophilic attack by hydroxide, leading to the cleavage and formation of the carboxylate salt and iodoform precipitate.^[17]^[18] Similarly, ethanol undergoes initial oxidation to acetaldehyde, which then follows the haloform pathway:

\ce{CH3CH2OH + 3I2 + 4NaOH -> CHI3 + HCOONa + 3NaI + 3H2O}

The procedure typically entails dissolving the substrate (e.g., 10-20 mL acetone or ethanol) in aqueous sodium hydroxide (10-20%), adding iodine crystals or potassium iodide with an oxidizing agent portionwise while warming gently (around 60°C) to maintain the reaction, often over 30-60 minutes until the iodine color persists no longer. The yellow iodoform precipitate forms and is isolated by filtration, washed with cold water, and dried.^[17]^[19] Another method involves electrolysis of a potassium iodide (KI) solution containing acetone or ethanol and sodium carbonate, where anodic oxidation generates hypoiodite in situ to drive the haloform reaction; typical conditions use a platinum anode and nickel cathode at low current (1-2 A) for 1-2 hours, yielding the yellow precipitate directly.^[20] Laboratory syntheses via the haloform reaction generally afford high yields of 80-90% after purification, with the crude product often recrystallized from ethanol or chloroform to achieve purity greater than 95%. The electrolytic method can reach current efficiencies near 98%, though overall yields depend on substrate concentration and electrolysis duration. These methods emphasize controlled conditions to minimize side reactions like over-iodination.^[21]^[22]

Natural occurrence

Iodoform occurs naturally in limited biological sources, primarily associated with specific fungi and marine bacteria. It is found in the angel's bonnet mushroom (Mycena arcangeliana), a saprotrophic fungus that grows on dead wood, where the compound imparts its distinctive medicinal odor.^[23] Strains of the marine bacterium Roseovarius spp., isolated from coastal environments, produce iodoform as part of their metabolism of iodine compounds. These bacteria generate free iodine and organic iodine derivatives, including iodoform, through enzymatic processes involving iodide oxidation. Reports of iodoform production by microorganisms remain scarce, and its presence in natural seawater is typically at trace levels.^[24]

Reactions

Iodoform reaction

The iodoform reaction is a variant of the haloform reaction, in which methyl ketones of the form RCOCH₃ or alcohols oxidizable to such ketones, such as RCH(OH)CH₃, undergo cleavage in the presence of iodine (I₂) and sodium hydroxide (NaOH) to yield iodoform (CHI₃) and the sodium salt of a carboxylic acid (RCOONa).^[25] This process was first observed in 1822 by Georges-Simon Serullas during studies of iodine reactions with alkaline solutions.^[25] The mechanism proceeds in two main stages: exhaustive α-halogenation followed by nucleophilic cleavage. Under basic conditions, the methyl ketone forms an enolate ion via deprotonation at the α-carbon, which reacts with iodine to introduce three iodine atoms, forming a triiodomethyl ketone (RCOCI₃). This intermediate then undergoes nucleophilic attack by hydroxide ion (OH⁻), leading to C-C bond cleavage and release of the triiodomethyl anion (⁻CI₃), which protonates to iodoform; the remaining acyl group forms the carboxylate.^[26] Enolization is typically the rate-limiting step in iodoform reactions due to the lower reactivity of iodine compared to other halogens.^[25] As a qualitative test, the iodoform reaction detects the presence of methyl ketone or acetaldehyde functionalities in organic compounds, producing a characteristic yellow precipitate of iodoform and discharge of the initial brown iodine color.^[27] The procedure involves adding a sample (typically 2-3 drops or 10-15 mg) to 2-3 mL of water or ethanol, followed by 10 drops of iodine-potassium iodide solution (KI/I₂) and dropwise addition of 10% NaOH until the solution turns colorless, often with gentle heating (60-70°C) for 5-10 minutes; a positive result appears as a yellow precipitate or oily layer, sometimes accompanied by an antiseptic odor.^[28]^[29] The test is specific to compounds containing the CH₃CO- group (as in methyl ketones like acetone, CH₃COCH₃) or the CH₃CH(OH)- group (as in primary alcohols like ethanol, CH₃CH₂OH, which oxidizes in situ to acetaldehyde, CH₃CHO, or secondary alcohols like 2-propanol, CH₃CH(OH)CH₃, which oxidizes to acetone); acetaldehyde itself also gives a positive response, yielding iodoform and sodium formate.^[25]^[30] For instance, acetone reacts to form iodoform and sodium acetate, while ethanol produces iodoform via its oxidation to acetaldehyde.^[25] This specificity distinguishes these structural motifs from other carbonyl compounds lacking the methyl group adjacent to the carbonyl.^[27]

Other reactions

Iodoform exhibits several additional chemical transformations due to its weak carbon-iodine bonds, which facilitate nucleophilic substitution and reduction processes. One notable reaction is its reduction to diiodomethane (CH₂I₂), achieved by treatment with red phosphorus and hydriodic acid; this stepwise dehalogenation replaces one iodine atom while preserving the geminal diiodo structure.^[31] Alternatively, iodoform can be reduced to diiodomethane using sodium arsenite in the presence of sodium hydroxide, as described in synthetic procedures for preparing the reagent.^[32] In aqueous alkaline conditions, iodoform undergoes hydrolysis to produce formate and iodide ions. The reaction proceeds as follows:

\text{CHI}_3 + 4\text{OH}^- \rightarrow \text{HCOO}^- + 3\text{I}^- + 2\text{H}_2\text{O}

This base-catalyzed cleavage mirrors the reverse of the final step in the haloform reaction mechanism and requires heating with strong alkali for completion.^[31] Iodoform reacts readily with silver nitrate in aqueous solution, forming a bright yellow precipitate of silver iodide (AgI), which is utilized in quantitative gravimetric analysis. The stoichiometry indicates that 1 gram of AgI corresponds to approximately 0.5590 grams of iodoform, highlighting its utility in analytical chemistry.^[1] Exposure to light induces photochemical decomposition of iodoform, leading to the release of iodine (I₂) through photodissociation of the C-I bonds. This process generates reactive intermediates such as the CHI₂ radical and iodine atoms, with potential applications in photochemical synthesis, and is evidenced by iodoform's absorption of light above 290 nm.^[1]

Applications

Medical uses

Iodoform exhibits antiseptic properties through the slow release of free iodine, which exerts a bactericidal effect by denaturing bacterial proteins and oxidizing essential cellular components.^[33] This mechanism, activated by wound secretions or enzymes like catalase, allows for sustained antimicrobial action without rapid depletion.^[6] Historically, iodoform has been employed as a healing and antiseptic agent in wound dressings and powders since the early 20th century, particularly for treating sores and surgical sites.^[6] Iodoform-impregnated gauze was commonly used to pack surgical cavities, such as those from abscess drainage or dental extractions, promoting granulation tissue formation while absorbing exudate and preventing infection.^[34] In oral surgery, it effectively reduced bacterial colonization on sutures and aided in managing post-operative wounds.^[35] In dentistry, iodoform remains a key component in pastes and powders for root canal disinfection and treatment of conditions like dry socket, often combined with eucalyptus oil or glycerin to enhance penetration and soothing effects.^[2] These formulations provide localized antimicrobial activity, helping to eliminate residual bacteria and facilitate healing in endodontic procedures.^[36] Contemporary medical applications of iodoform are limited due to the availability of safer, more effective alternatives like chlorhexidine or povidone-iodine, rendering it uncommon in general human wound care.^[37] However, it persists in specialized human contexts such as ENT surgery, neurosurgery, and oral/maxillofacial procedures, as well as veterinary medicine for ear powders in dogs and cats to prevent infections during hair removal and aural treatments, and in some tropical medicine settings for managing chronic skin ulcers and infections where modern antiseptics may be less accessible.^[3]^[38]^[39]

Other applications

Iodoform serves as a key analytical reagent in organic qualitative analysis, particularly through the iodoform test, which detects the presence of methyl ketones or acetaldehyde by producing a characteristic yellow precipitate of iodoform itself when the sample is treated with iodine and base.^[40] This test is widely employed in laboratory settings to identify compounds with a CH₃CO- group. In industrial applications, iodoform functions as a transfer agent in radical polymerizations, enabling controlled synthesis of polymers such as poly(methyl acrylate) and polystyrene by regulating chain growth and molecular weight distribution.^[41] It is also utilized as a polymerization control agent and component in adhesives, where it contributes to the stability and performance of polymer-based formulations under regulatory standards for food-contact materials. Additionally, iodoform acts as a sensitizing agent in certain printing processes, enhancing the reactivity of photochemical systems.^[42] Modern niche applications include its role as an initiator in living radical polymerization of vinyl chloride, facilitating the production of polyvinyl chloride with narrow polydispersity indices at ambient temperatures.^[43]

History

Discovery

Iodoform, chemically known as triiodomethane (CHI₃), was first discovered in 1822 by the French chemist Georges-Simon Serullas during his investigations into the compounds of iodine, a recently isolated element.^[25] This breakthrough occurred amid early 19th-century explorations of organic halogen chemistry, building on the 1811 discovery of iodine itself and preceding similar findings for other haloforms like chloroform in 1831.^[25] Serullas's work represented one of the initial forays into synthesizing halogenated hydrocarbons, highlighting the reactivity of iodine with organic substrates under specific conditions.^[25] Serullas achieved the initial synthesis of iodoform by passing a mixture of iodine vapor and steam over red-hot coals, which yielded the compound as a distinctive product.^[3] In a related experiment detailed in the same study, he also produced iodoform through the reaction of potassium metal with a solution of iodine in aqueous ethanol, resulting in a yellow precipitate he termed "hydroiodide of carbon."^[25] These methods marked the serendipitous identification of what would later be recognized as the haloform reaction, though Serullas did not fully elucidate the mechanism at the time.^[25] Early observations of iodoform emphasized its pale yellow crystalline appearance and volatility, characteristics noted by Serullas and confirmed by contemporaries in the chemical community.^[25] These properties distinguished it from other iodine derivatives and sparked interest in its potential applications, though initial focus remained on its chemical novelty rather than practical uses.^[3]

Development and decline

Following the recognition of its antiseptic properties in 1880, iodoform gained rapid adoption among surgeons for antisepsis during operations, particularly in wound dressings where it supplanted earlier wet methods with dry iodoform gauze to reduce infection risks.^[44]^[45] This marked a significant advancement in surgical practice amid the broader shift toward antiseptic techniques in the late 19th century. By the early 20th century, iodoform reached its peak usage in hospitals worldwide, serving as a standard healing and antiseptic agent in dressings and powders for wounds, sores, and surgical cavities, contributing to improved postoperative outcomes in an era before widespread antibiotics.^[6] Its distinctive yellow color and odor became hallmarks of routine hospital care, with applications extending to dental and veterinary settings for similar antimicrobial purposes.^[1] The prominence of iodoform began to wane in the post-1940s period as safer and more effective alternatives emerged, including antibiotics like penicillin introduced in the early 1940s and antiseptics such as chlorhexidine developed in the 1950s, which offered broader-spectrum activity with fewer side effects.^[44] Additionally, accumulating evidence of iodoform's toxicity—manifesting as neurotoxicity, systemic iodine overload, and hypersensitivity reactions—further diminished its favorability by the 1960s, prompting restrictions on its extensive use in large wounds.^[46]^[47] Despite its decline, iodoform's role as an early organic iodinated antiseptic influenced the development of subsequent compounds, such as povidone-iodine in the mid-20th century, which retained iodine's antimicrobial benefits while mitigating toxicity through better solubility and controlled release.^[48] This legacy underscores iodoform's foundational impact on modern iodinated antiseptics still employed in targeted clinical scenarios.^[3]

Safety and toxicity

Health hazards

Iodoform can be absorbed through inhalation, dermal contact, or ingestion, with rapid uptake via denuded skin, wounds, or mucous membranes.^[1] The oral LD50 in rats is 355 mg/kg, indicating moderate acute toxicity.^[49] Acute exposure to iodoform primarily causes irritation to the skin and eyes, often manifesting as redness, itching, or burning sensations upon contact.^[50] Inhalation of its vapors may lead to respiratory distress, including irritation of the upper respiratory tract and potential coughing or shortness of breath.^[51] At higher exposure levels, narcotic-like effects such as dizziness, headache, central nervous system depression, delirium, and hallucinations have been reported, particularly when absorbed through wounds during topical use.^[1]^[49] Chronic exposure to iodoform may result in thyroid disruption due to iodine overload, with case reports documenting thyrotoxicosis and hypothyroidism in affected individuals.^[52]^[53] It exhibits cytotoxic effects on cells, including macrophages, where high concentrations induce cell death and inhibit proliferation in both direct and indirect exposures.^[54] Additionally, iodoform can cause dermal sensitization, leading to allergic contact dermatitis characterized by itching, rash, or eczema upon repeated exposure.^[50] Its volatile nature contributes to secondary exposure risks through inhalation of iodine vapors released during decomposition.^[46] Iodoform is contraindicated in individuals with known hypersensitivity to it, as severe allergic reactions, including swelling and difficulty breathing, have been observed.^[55]^[56]

Regulatory aspects

Iodoform is subject to occupational exposure limits to protect workers from its irritant and toxic effects. The National Institute for Occupational Safety and Health (NIOSH) establishes a recommended exposure limit (REL) of 0.6 ppm (10 mg/m³) as a 10-hour time-weighted average (TWA), with a skin notation indicating potential absorption through the skin.^[10] The Occupational Safety and Health Administration (OSHA) has not set a specific permissible exposure limit (PEL) for iodoform but requires adherence to general industry standards for controlling exposure to hazardous chemicals, often referencing NIOSH or other guidelines.^[57] Under European Union regulations, iodoform is classified under the Classification, Labelling and Packaging (CLP) Regulation (EC) No 1272/2008 as Acute toxicity category 4 (oral and dermal; H302, H312), Acute toxicity category 3 (inhalation; H331), Skin irritation category 2 (H315), Eye irritation category 2 (H319), Specific target organ toxicity – single exposure category 3, respiratory tract irritation (H335), and Hazardous to the aquatic environment acute and chronic category 2 (H411).^[58] It is not classified as a carcinogen by major regulatory bodies, such as the International Agency for Research on Cancer (IARC) or the European Chemicals Agency (ECHA), though iodine-containing compounds are subject to ongoing monitoring for potential endocrine and developmental effects. Handling protocols for iodoform emphasize engineering controls and personal protective equipment (PPE) to mitigate exposure risks. Operations involving iodoform should be conducted in a chemical fume hood or well-ventilated area to prevent inhalation of vapors or dust.^[59] Required PPE includes chemical-resistant gloves, safety goggles or face shields, and protective clothing; respiratory protection may be necessary if exposure limits are exceeded.^[50] Storage must occur in tightly sealed containers in a cool, dry, well-ventilated area, separated from incompatible substances such as strong oxidizers, alkali metals, and reducing agents to avoid violent reactions.^[50] Disposal of iodoform is regulated as hazardous waste by the U.S. Environmental Protection Agency (EPA) under the Resource Conservation and Recovery Act (RCRA), due to its toxicity characteristic; generators must evaluate it per 40 CFR Part 261 and dispose of it through permitted treatment, storage, and disposal facilities.^[59] In consumer products, its use is restricted; for instance, the U.S. Food and Drug Administration (FDA) permits iodoform only as an indirect food additive in limited applications, such as a polymerization-control agent in adhesives for food-contact materials, to minimize public exposure.^[1] These regulations stem from iodoform's irritant effects, ensuring safe occupational and environmental management.^[50]

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Dec 15, 2024 · Historical evolution. The synthesis of iodoform was first described in 1822 by Georges-Simon Serullas, a French professor of pharmacy, who ...
[48]
TOXIC PSYCHOSIS DUE TO IODOFORM - Psychiatry Online
Toxic psychosis due to iodoform hypersensitivity is uncommon and is rarely recognized. It generally occurs when the drug is painted on large surfaces which ...
[49]
(PDF) The Role of Iodine in Antisepsis and Wound Management
Aug 6, 2025 · For more than 150 years, iodine has been used for the prevention of infection and for the treatment of wounds. Nowadays a large amount of ...Missing: influence iodinated
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[PDF] Iodoform - Safety Data Sheet - ChemicalBook
Information on toxicological effects. Acute toxicity. LD50 Oral - Rat - 355 mg/kg. Remarks: Behavioral:Altered sleep time (including change in righting reflex) ...
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[PDF] workplace exposure limits - NJ.gov
HAZARD SUMMARY. * Iodoform can affect you when breathed in and by passing through your skin. * Contact can irritate the skin and eyes.Missing: narcotic | Show results with:narcotic
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[PDF] SAFETY DATA SHEET - Lab Alley
Feb 20, 2025 · Toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment. Product. Species. Test Results. Iodoform. LC50.
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Iodoform induced thyrotoxicosis in the elderly: case report and ...
Dec 15, 2019 · Background. Drug-induced hyperthyroidism is a rare condition linked to dietary supplements, iodine-containing medications and intentional or ...
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Iodoform: Neurologic impairment and hypothyroidism: 2 case reports
Jun 12, 2021 · In a case series, a 56-year old man and a 64-year-old man were described, who developed neurologic impairment and hypothyroidism during ...
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Cytotoxicity and proliferative effects of Iodoform-containing root ...
Conclusions: Direct and indirect exposure to high concentrations of iodoform-containing root canal filling material showed a cytotoxic effect on macrophages and ...
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Avoidance of BIPP allergy hypersensitivity reactions following ear ...
The component part responsible is iodoform not iodine. We recommend patch testing patients previously exposed to BIPP undergoing ear surgery, if postoperative ...
[57]
Allergic reaction after iodoform-containing intracanal medication ...
Sep 28, 2025 · This report presents a rare case of severe allergic reaction to iodoform following endodontic root canal treatment. A 24-year-old healthy female ...
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IODOFORM | Occupational Safety and Health Administration - OSHA
Dec 31, 2020 · Boiling point, 424°F (sublimes) ; Molecular weight, 393.73 ; Freezing point/melting point, 246°F ; Flash point, Vapor density ; Vapor density, 4.1.<|control11|><|separator|>
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Iodoform Triiodomethane USP Grade n Pure Manufacturers, with SDS
Classification according to EU Directives 67/548/EEC or 1999/45/EC: Xn = Harmful Xi = Irritant N = Dangerous for the environment. R20/22 Harmful by inhalation ...
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[PDF] SAFETY DATA SHEET - Fisher Scientific
Nov 9, 2009 · Acute Inhalation Toxicity - Dusts and Mists ... Delayed and immediate effects as well as chronic effects from short and long-term exposure.