Crepitus is a clinical sign in medicine characterized by a peculiar crackling, crinkly, or grating feeling or sound that can occur under the skin, around the lungs, or within joints.[1] This phenomenon arises from friction between tissues, gas bubbles, or structural irregularities, and it may be audible, palpable, or both, depending on the underlying cause.[2] While often benign, crepitus can signal pathological conditions such as arthritis, fractures, or emphysema, warranting medical evaluation when accompanied by pain, swelling, or functional limitations.[3]In musculoskeletal contexts, crepitus most commonly manifests as popping, clicking, or grinding noises during joint movement, affecting areas like the knees, shoulders, or neck.[4] It can result from harmless mechanisms, such as the collapse of nitrogen gas bubbles within synovial fluid (as in knuckle-cracking), or from pathological processes like cartilage degeneration in osteoarthritis or rheumatoid arthritis, where roughened joint surfaces rub together.[3][4] Other causes include tendon or ligament snapping over bony prominences, tenosynovitis, fractures with bone fragments, or bursitis, with crepitus classified as coarse (loud and prominent in advanced disease) or fine (subtle in early or mild cases).[2] Painless crepitus is typically not concerning and does not lead to arthritis, but symptomatic cases may require treatments like physical therapy, anti-inflammatory medications, or, in severe arthritis, surgical interventions such as joint replacement.[4][3]Pulmonary crepitus refers to crackling sounds or sensations over the chest, often due to air trapped in subcutaneous tissues from conditions like subcutaneous emphysema.[1] Common causes include pneumothorax (lung collapse), airway or esophageal rupture, or barotrauma from mechanical ventilation, where air escapes into surrounding tissues.[5] This type is assessed through palpation and auscultation during breathing, and imaging such as CT scans confirms the diagnosis; treatment focuses on resolving the underlying issue, with crepitus often resolving spontaneously once the source is addressed.[5]Subcutaneous crepitus specifically involves gas (typically air) infiltrating soft tissues beneath the skin, producing a palpable crunching sensation akin to rubbing hair between fingers.[1] It is frequently associated with trauma, infections, or surgical complications that allow gas to enter tissues, and while it can occur near joints or lungs, it is distinct in its soft-tissue focus.[5] Clinically, it signals potential emergencies like gas gangrene or necrotizing infections, necessitating prompt intervention such as antibiotics or debridement.[2] Across all forms, crepitus serves as a diagnostic clue, guiding healthcare providers toward targeted evaluations and management to prevent complications.[3]
Etymology and Definition
Etymology
The term "crepitus" originates from the Latin noun crepitus, meaning "a rattling" or "creaking" sound, derived from the verb crepare, which signifies "to rattle," "crack," or "burst."[6][7] This root reflects onomatopoeic qualities mimicking abrupt, noisy disruptions, and it connects to related Latin terms such as crepitaculum, an ancient Roman percussion instrument resembling a rattle or castanets used in rituals.[6] The word also influences modern English vocabulary, including "decrepit," which stems from Latin decrepit ("very old, worn out"), combining the prefixde- (indicating deterioration) with crepitus to evoke the creaking frailty of age.[8]In English, "crepitus" first appeared around 1820 as a general descriptor for crackling noises, but its medical adoption occurred in the 19th century, initially to denote the grating friction sounds between fractured bone fragments.[6][9] Ancient physicians, such as Hippocrates and Galen, had long recognized the diagnostic value of such audible bone friction in identifying fractures—termed crepitus in later Latin texts—but the specific term entered English medical literature during this period as diagnostic techniques advanced with tools like percussion (introduced by Leopold Auenbrugger in 1761) and the stethoscope (by René Laennec in 1819).[9] By 1834, its usage expanded to describe crackling lung sounds in conditions like pneumonia, marking a shift from orthopedic to respiratory contexts.[6]Over time, the term evolved in medical parlance to encompass broader applications, including palpable crackling in subcutaneous tissues from gas accumulation and grinding sensations in joints due to cartilage irregularities, while retaining its core association with audible or tactile rattling.[9] This progression reflects the term's versatility in capturing diverse pathological noises without altering its foundational Latin etymology.[6]
Definition
Crepitus, derived from the Latin crepitus meaning "a rattling" or "creaking," is a clinical sign in medicine characterized by a peculiar crackling, crinkly, grating, popping, or crunching sound or sensation produced by friction between bones, cartilage, tissues, or the presence of gas within body structures.[6][1][10] This phenomenon arises from mechanical interactions or air movement in various anatomical sites, such as joints, subcutaneous tissues, or pulmonary regions.[2][5]Crepitus is distinguished by its sensory qualities: audible crepitus refers to sounds that can be heard externally or detected via stethoscope, often described as crackling or popping, while palpable crepitus involves a tactile vibration or grinding sensation felt by the examiner or patient during touch or active movement.[2][5][11] These manifestations may occur with or without accompanying discomfort, depending on the underlying mechanism.[2]In clinical practice, crepitus holds significance as an indicator of potential mechanical disruptions, such as tissue friction or bone irregularities, gas accumulation in soft tissues, or inflammatory changes, but it represents a symptom rather than a standalone disease.[3][12][4] Forms of crepitus can be benign, especially when isolated and asymptomatic, or pathological, warranting further evaluation if associated with pain, swelling, or functional impairment.[12][4]
Types of Crepitus
Articular Crepitus
Articular crepitus refers to the grinding, grating, crackling, or popping sounds and sensations produced within a joint during active or passive movement.[4][13] This phenomenon arises from friction between joint surfaces, distinguishing it from general crepitus as a friction-based noise specific to synovial joints.[2]The associated sensations often include a palpable vibration or roughness felt under the skin as the joint moves, which may be audible or subtle depending on the joint's location and the individual's perception.[4][2] In the knee, for instance, this can manifest as a coarse grating during flexion or extension, particularly in the patellofemoral compartment.[13]Articular crepitus commonly occurs in weight-bearing joints such as the knee, where patellofemoral crepitus is frequent due to cartilage wear, as well as in the shoulders and knuckles.[4][13] Shoulder crepitus typically presents as crackling or grinding during rotation or elevation, while knuckle involvement often involves popping sensations during flexion.[14][4]It differs from other joint noises, such as cavitation, which involves the painless collapse of gas bubbles within the synovial fluid and produces a sharp, singular pop without ongoing friction.[4][13] Unlike cavitation, articular crepitus tends to be repetitive and linked to surface irregularities rather than fluid dynamics.[13]
Subcutaneous Crepitus
Subcutaneous crepitus refers to the palpable crackling sensation produced by air or gas trapped within the subcutaneous tissues, distinguishing it as a superficial form of crepitus related to gas movement under the skin.[15]This crepitus is characterized by a distinctive crackling or crunching feeling upon palpation or movement over the affected skin, often likened to the sound of touching Rice Krispies or separating Velcro due to the displacement of gas bubbles through soft tissues.[16][17] The sensation is typically elicited by gentle pressure on the skin surface, creating a palpable popping or grating effect that is immediately noticeable.[18]It commonly manifests in areas such as the neck, chest, face, or limbs, where the gas accumulation produces localized involvement that can extend along fascial planes.[19] This distribution reflects the tendency of air to track through connective tissues, potentially leading to widespread but superficial involvement.[18]Subcutaneous crepitus is frequently associated with visible subcutaneous emphysema, presenting as soft tissue swelling or a smooth bulging of the skin due to trapped air, which enhances the crackling palpation.[15] Unlike articular crepitus, which arises from intra-articular friction and requires joint motion to produce sounds, subcutaneous crepitus is distinctly superficial and detectable through direct skin palpation without any joint involvement.[19]
Pulmonary Crepitus
Pulmonary crepitus refers to the palpable crackling sensation detected over the chest wall, resulting from air trapped in the subcutaneous tissues of the thoracic region, often due to leakage from pulmonary structures.[5][20] This form of crepitus is elicited by palpation of the skin over the lungs, producing a crunching or popping feeling similar to rubbing hair between fingers or the sound of Rice Krispies, as gas shifts within the soft tissues.[15][18]It typically arises in conditions involving air escape from the lungs or airways, such as pneumothorax, tracheobronchial rupture, or barotrauma, where air tracks into the subcutaneous layer along fascial planes, commonly affecting the neck, chest, and upper torso.[5][21] The involvement is often localized to the anterior chest but can spread bilaterally or superiorly, and it may accompany visible swelling or creasing of the skin due to subcutaneous emphysema.[19]Pulmonary crepitus is distinct from intra-pulmonary adventitious sounds like crackles, which are auscultated internally during respiration and relate to airway or alveolar dynamics rather than subcutaneous gas.[5] Instead, it serves as a physical sign of potential thoracic emergencies, requiring correlation with symptoms such as dyspnea or chest pain for diagnosis.[15]
Articular crepitus can arise from benign mechanisms, primarily involving the cavitation of synovial fluid within the joint space. When negative pressure is applied during joint manipulation or movement, dissolved gases such as nitrogen in the synovial fluid form bubbles that rapidly collapse, producing an audible cracking or popping sound.[22] This process, known as tribonucleation, creates a refractory period of approximately 20 minutes before the joint can produce the sound again, as the gases must redissolve into the fluid.[23]Pathological articular crepitus often stems from degenerative or inflammatory joint conditions that alter the smoothness of articular surfaces. In osteoarthritis, the progressive degeneration of cartilage leads to irregular, eroded surfaces that generate grating sensations and sounds during motion.[24] Similarly, rheumatoid arthritis involves synovial inflammation and pannus formation, which erode cartilage and subchondral bone, contributing to crepitus through frictional irregularities.[25] Roughened bone ends from fractures can also produce crepitus when they rub against each other during joint movement.[2] Additionally, fibrinous deposits in conditions like bursitis or tenosynovitis may create abrasive particles within the joint or surrounding structures, exacerbating the grating noise.[2]The underlying pathophysiology of pathological crepitus typically involves increased friction between irregular joint surfaces or the presence of intra-articular debris. Eroded or fibrillated cartilage exposes rough subchondral bone, leading to mechanical grating as the joint articulates.[11] Loose bodies, such as fragments of cartilage or bone, can migrate within the joint space, colliding with articular surfaces and producing audible crepitus through intermittent impacts or sustained friction.[26] These mechanisms disrupt the normal low-friction gliding of synovial joints, often accompanied by inflammation that further roughens tissues.[27]Several risk factors predispose individuals to articular crepitus, particularly through their association with joint degeneration. Advanced age increases susceptibility due to cumulative wear on cartilage and reduced regenerative capacity.[28]Obesity elevates mechanical stress on weight-bearing joints like the knees and hips, accelerating cartilage breakdown.[29] Repetitive stress from occupational or athletic activities, such as squatting or high-impact sports, contributes to microtrauma and subsequent crepitus development.[30] Prior joint injuries, including ligament tears or meniscal damage, further heighten risk by altering biomechanics and promoting uneven loading.[31]
In Subcutaneous Crepitus
Subcutaneous crepitus, also known as subcutaneous emphysema, primarily arises from the introduction of air into the subcutaneous tissues through external or internal breaches. The most common causes include trauma, such as blunt or penetrating injuries to the chest, neck, or face, which allow air to enter directly into soft tissues.[18] Surgical procedures, particularly those involving the thorax or airways like endotracheal intubation or central line placement, can lead to what is termed surgical emphysema, where air escapes into the subcutaneous plane during manipulation.[15] Additionally, ruptured airways, such as in pneumothorax or tracheal injuries often associated with underlying conditions like chronic obstructive pulmonary disease, permit air to track from the respiratory system into surrounding tissues.[32]The pathophysiology involves air entering the subcutaneous space and dissecting along fascial planes, originating from the mediastinum, perforations, or direct entry points, resulting in the accumulation of gas bubbles that produce a characteristic palpable crackling sensation without significant pain in noninfectious cases.[32] This gas migration can extend from the chest wall to the neck, face, or even distant sites like the abdomen, depending on the pressure gradients and tissue connectivity, but it typically remains confined to soft tissues unless complicated by infection.[18]Infectious etiologies contribute to subcutaneous crepitus through the production of gas by anaerobic bacteria, notably Clostridium perfringens, which causes gas gangrene or clostridial myonecrosis. In this process, the bacteria thrive in hypoxic environments, releasing exotoxins like alpha-toxin that disrupt cell membranes and connective tissues, leading to tissue necrosis and fermentation that generates hydrogen and carbon dioxide gases, manifesting as crepitus in the subcutaneous layers.[33] Similarly, certain cases of necrotizing fasciitis involve gas-forming organisms that propagate along fascial planes, exacerbating gas accumulation and local tissue destruction.[15]Rare causes encompass barotrauma from scuba diving, where rapid pressure changes during ascent cause alveolar rupture, allowing air to dissect into the mediastinum and subsequently the subcutaneous tissues.[34] Complications from mechanical ventilation, such as high airway pressures leading to alveolar overdistension and rupture, can also result in air tracking along perivascular sheaths to produce subcutaneous emphysema.[32]
In Pulmonary Crepitus
Pulmonary crepitus manifests as crackling sensations or sounds over the chest wall due to air trapped in the subcutaneous tissues overlying the lungs, typically as a form of localized subcutaneous emphysema originating from respiratory tract disruptions.[5] Key causes include pneumothorax, where lung collapse allows air to escape into the pleural space and track into subcutaneous tissues; tracheobronchial or esophageal rupture from trauma, intubation, or spontaneous events; and barotrauma associated with mechanical ventilation or positive pressure scenarios.[18][5]The pathophysiology parallels that of subcutaneous crepitus but is specific to thoracic sources, with air leaking from alveoli, airways, or mediastinum under pressure gradients, dissecting along perivascular and fascial planes to accumulate in the soft tissues of the chest, neck, and sometimes face, producing the palpable crunching or crackling upon palpation or movement.[15] This gas buildup creates a spongy texture and audible/ tactile crepitus resembling snow crunching or Rice Krispies, often without initial pain unless infection or tension develops, and it signals potential emergencies like tension pneumothorax requiring immediate intervention.[18]Associated conditions include underlying lung diseases like chronic obstructive pulmonary disease (COPD) that predispose to spontaneous pneumothorax, or iatrogenic causes from procedures, leading to mediastinal and subcutaneous air extension.[32] Differentiation from intra-pulmonary sounds like crackles is essential, as pulmonary crepitus is extra-pulmonary and detected primarily by palpation rather than auscultation alone.[5]
Diagnosis
Physical Examination
Physical examination for crepitus involves direct palpation and auscultation to detect abnormal crackling, grinding, or popping sensations and sounds arising from air or tissue disruption in joints, subcutaneous tissues, or lungs. This hands-on assessment is essential for initial detection and localization, often performed in conjunction with evaluating associated symptoms like pain or swelling.[35]For articular crepitus, the examiner assesses joints through active and passive range-of-motion tests, where the patient or clinician moves the joint to elicit popping or grinding noises indicative of cartilage irregularities. Palpation during these maneuvers detects vibrations or grating sensations, particularly in weight-bearingjoints like the knee; for instance, gently flexing and extending the knee while stabilizing the patella can reveal crepitus suggesting degenerative changes. In the knee, specific tests such as the Waldron sign—compressing the joint during squatting—or the grind test, applying force to the patella during quadriceps contraction, help localize patellofemoral involvement. These findings are correlated with pain on movement or joint effusion to gauge severity.[35][36]Subcutaneous crepitus is identified by gentle palpation of the skin, producing a characteristic crackling sensation or sound from air trapped in soft tissues, most commonly along the neck or chest in cases of emphysema. The examiner presses lightly on swollen areas to confirm the palpable air pockets, distinguishing it from fluid edema by the audible or tactile "rice krispies" feel. This exam is typically performed with the patient supine or seated to access affected regions, noting any extension to the face or upper body.[15][32]Pulmonary crepitus is detected by palpation over the chest wall, producing a crackling sensation from air trapped in subcutaneous tissues, often extending from the neck to the thorax in conditions like subcutaneous emphysema. The examiner lightly presses on the chest or supraclavicular areas to elicit the palpable crepitus, distinguishing it from other swellings; auscultation may reveal associated abnormal breath sounds such as diminished air entry if an underlying pneumothorax is present. This exam is performed with the patient supine or seated to assess thoracic involvement.[15][37]General considerations include positioning the patient to optimize access—such as sitting for pulmonary exam or supine for jointpalpation—and integrating findings with tenderness or functional limitations to guide further evaluation.[35]
Imaging and Other Tests
In the evaluation of articular crepitus, plain radiographs (X-rays) serve as the initial imaging modality to detect underlying structural abnormalities such as osteoarthritis, joint space narrowing, osteophytes, or fractures that may contribute to the grating sensation during movement.[38][39]Magnetic resonance imaging (MRI) is particularly useful for assessing soft tissue and cartilage damage, including meniscal tears, ligament injuries, or early degenerative changes not visible on X-rays, providing detailed visualization of intra-articular pathology.[40]Ultrasound offers real-time dynamic assessment of joint effusion, synovial inflammation, and tendon involvement, making it valuable for guiding interventions or evaluating crepitus in accessible joints like the knee or shoulder.[41]For subcutaneous crepitus, which often indicates air trapped in soft tissues due to conditions like pneumomediastinum, chest X-rays are the first-line imaging to identify mediastinal air and extension into subcutaneous planes, revealing linear lucencies or the Naclerio V sign.[42] Computed tomography (CT) of the chest provides higher sensitivity for confirming the source of air leakage, such as esophageal or tracheal rupture, and delineating the extent of emphysema.[43] Routine laboratory tests are not typically required unless signs of infection, such as fever or leukocytosis, suggest a complicating factor like gas-forming organisms.[15]Pulmonary crepitus is evaluated with chest X-rays as the initial imaging to detect subcutaneous air over the thorax, appearing as lucent streaks in soft tissues, often with signs of underlying causes like pneumothorax or pneumomediastinum. High-resolution CT scans of the chest offer superior detail to confirm the extent of subcutaneous emphysema and identify the source, such as airway rupture or barotrauma.[44][42]In cases of articular crepitus associated with inflammatory or infectious processes, arthrocentesis allows aspiration of synovial fluid for analysis, including cell count, Gram stain, culture, and crystal examination, to differentiate septic arthritis, gout, or pseudogout from noninflammatory causes.[45]
Treatment and Management
Conservative Approaches
Conservative approaches to managing crepitus primarily aim to alleviate symptoms, reduce inflammation, and address underlying causes without invasive interventions. For joint-related (articular) crepitus, often associated with osteoarthritis or minor injuries, the RICE protocol—rest, ice, compression, and elevation—is a standard initial strategy to minimize pain and swelling. Rest involves avoiding activities that exacerbate symptoms, while ice application for 15-20 minutes several times daily helps constrict blood vessels and reduce inflammation; compression with an elastic bandage and elevation above heart level further aid in controlling edema. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are commonly recommended to manage pain and inflammation in articular crepitus, with typical dosing of 200-400 mg every 6-8 hours as needed, though gastrointestinal risks should be considered.[46][47]In cases of articular crepitus, particularly in the knee, physical therapy plays a central role in strengthening surrounding muscles to improve jointstability and reduce mechanical stress. Exercises targeting the quadriceps, such as straight-leg raises or mini-squats, can enhance muscle support and alleviate crepitus over 4-6 weeks of supervised sessions. Weight management is also crucial, as each pound of excess body weight increases kneejoint load by approximately 4 pounds during walking; a 10% reduction in body weight can significantly decrease pain in osteoarthritis-related crepitus.[48][49]For subcutaneous crepitus, often resulting from air trapping in tissues due to trauma or infection, conservative management emphasizes observation and supportive care if the condition is benign and stable. High-flow oxygen therapy accelerates nitrogen washout, promoting faster reabsorption of subcutaneous air, typically administered at 100% oxygen via mask for 24-48 hours. In infection-related cases, such as those secondary to necrotizing soft tissueinfections, broad-spectrum antibiotics such as penicillin G and clindamycin are initiated empirically to target potential pathogens, with adjustments based on culture results.[32][15]Pulmonary crepitus, manifesting as palpable crackling sensations or sounds over the chest due to air trapped in subcutaneous tissues or interstitial spaces, is similarly managed conservatively with close monitoring and oxygen supplementation to improve oxygenation and resolve symptoms spontaneously in mild cases. Bed rest and analgesia support recovery, while supplemental oxygen at 2-4 liters per minute via nasal cannula helps reduce air trapping in conditions like pneumomediastinum. If linked to infection, antibiotics are employed as per the underlying etiology, such as in pneumonia.[50][20][15]Lifestyle modifications complement these strategies across crepitus types by preventing exacerbation. Avoiding repetitive motions, such as prolonged squatting or heavy lifting in joint-related cases, reduces cumulative stress on affected areas. Adequate hydration supports synovial fluid viscosity in joints, as synovial fluid is primarily composed of water.[51]
Surgical and Interventional Treatments
Surgical and interventional treatments for crepitus are indicated when conservative management fails to provide relief, particularly in cases of persistent pain, substantial functional impairment, or progression of the underlying condition.[28] These interventions target structural abnormalities or acute complications across articular, subcutaneous, and pulmonary manifestations, aiming to restore function and halt disease advancement.[52]In articular crepitus, often linked to osteoarthritis or cartilage degeneration, arthroscopy is a key minimally invasive procedure that allows visualization and treatment of joint interiors through small incisions. Surgeons use it to remove loose bodies—fragments of cartilage or bone that contribute to grinding sensations—and to debride inflamed or damaged synovial tissue and cartilage, thereby reducing crepitus and improving joint mobility.[53] For advanced osteoarthritis where crepitus accompanies severe joint destruction, total joint replacement, such as hip or knee arthroplasty, replaces eroded surfaces with prosthetic components, effectively eliminating crepitus and restoring weight-bearing capacity in appropriately selected patients.[54]Subcutaneous crepitus, arising from air trapped in tissues due to pneumothorax or infections like gas gangrene, requires prompt interventional measures to prevent extension. Chest tube thoracostomy is the primary treatment for pneumothorax-induced subcutaneous emphysema, involving insertion of a tube into the pleural space to evacuate air and re-expand the lung, thereby resolving the palpable crepitus.[55] In gas gangrene, characterized by gas production from clostridial infection, urgent surgical drainage combined with extensive debridement removes necrotic tissue and irrigates the wound to eradicate the source of crepitus, often necessitating repeated procedures until infection control is achieved.[33]Pulmonary crepitus, typically from alveolar rupture or fluid accumulation, infrequently demands direct surgical intervention but may involve bronchoscopy to address contributing factors like retained secretions. Flexible bronchoscopy enables suctioning of mucus plugs or excessive bronchial secretions that exacerbate crackling sounds during respiration, facilitating airway clearance and symptom mitigation in select cases.[56]
Prognosis and Complications
Prognosis
The prognosis for crepitus varies significantly depending on its type, underlying cause, and associated conditions. In benign articular crepitus, such as habitual knuckle cracking, outcomes are excellent with no evidence of long-term joint damage or increased risk of arthritis.[57][58] This phenomenon arises from the collapse of gas bubbles in synovial fluid and is considered harmless when performed without excessive force.[57]For pathological articular crepitus, often linked to osteoarthritis, the prognosis is variable but generally involves slow disease progression that can be managed to minimize disability. Cartilage degeneration is irreversible, yet conservative and surgical interventions effectively alleviate symptoms and maintain function in many cases.[59][60] Crepitus itself does not predict accelerated worsening of osteoarthritis over time.[61]Subcutaneous crepitus related to trauma typically has a good prognosis, with air absorption occurring spontaneously over days to weeks without intervention.[15][19] In contrast, when caused by infections such as gas gangrene from Clostridium species, the outlook is poor, with mortality rates ranging from 20% to 100% depending on treatment timeliness.[33][62]Pulmonary crepitus, arising from subcutaneous emphysema in the chest wall due to air leaks such as pneumothorax or barotrauma, generally has a favorable prognosis when the underlying cause is promptly treated, with air often reabsorbing spontaneously over days to weeks.[15][19] For traumatic or iatrogenic causes, outcomes are excellent with interventions like chest tube drainage; however, if associated with infections or delayed treatment, progression to severe complications can worsen prognosis.[63]Key factors influencing crepitus prognosis across types include early intervention, which can prevent progression in both articular and pulmonary cases, as well as patient age and comorbidities, where advanced age over 60 years and conditions like diabetes or hypertension correlate with poorer recovery and persistent symptoms.[64][65] Adherence to prescribed treatments further enhances overall outcomes.[60]
Complications
Complications of crepitus vary depending on its underlying cause and location, potentially leading to significant morbidity if untreated. In articular crepitus, often associated with osteoarthritis or joint degeneration, accelerated cartilage wear can result in joint instability and malalignment, increasing the risk of falls and reduced mobility.[66] Chronic progression may cause ankylosis, where the joint fuses, severely limiting range of motion and function, particularly in the temporomandibular joint following trauma.[67] Persistent crepitus also contributes to chronic pain syndromes, exacerbating disability and lowering quality of life through ongoing inflammation and mechanical symptoms.[68]Subcutaneous crepitus, typically arising from gas accumulation due to trauma, infection, or procedural errors, carries risks of rapid progression to severe systemic issues. When linked to gas-forming infections like necrotizing fasciitis, it can facilitate the spread of pathogens, leading to sepsis and toxic shock syndrome with high mortality if not addressed promptly.[69] Involvement of the neck or facial regions may cause airway compromise through tissue compression, potentially resulting in obstruction and respiratory distress.[70] In severe cases, extensive air trapping can evolve into tension emphysema, inducing hypercarbia, acidosis, and cardiovascular strain from mediastinal shift.[71]Pulmonary crepitus from subcutaneous emphysema in the chest can lead to respiratory compromise through airway compression or restricted lung expansion, potentially causing hypoxia or ventilatory failure if extensive.[72] Severe cases may result in pneumomediastinum, mediastinal shift, or tension physiology, contributing to cardiovascular instability or cardiac arrest.[73] Additional risks include compartment syndrome, skin necrosis, or interference with devices like pacemakers.[74]Beyond site-specific risks, crepitus can have broader implications, including psychological effects from persistent audible joint noises or pain, fostering anxiety, negative self-perceptions, and reduced physical activity.[75] Iatrogenic complications from interventions, such as air-driven dental tools or joint procedures, may induce subcutaneous emphysema, leading to swelling, infection, or rare airway threats requiring urgent management.[76]