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Delayed ejaculation

Delayed ejaculation is a male sexual dysfunction defined as a persistent or recurrent delay in ejaculation, or absence of ejaculation, during sexual activity that is normally conducive to ejaculation, despite the presence of adequate sexual stimulation and desire, often requiring more than 30 minutes of stimulation or resulting in anejaculation.^[1]^[2]^[3] This condition can be classified as lifelong (present since first sexual experiences) or acquired (developing after a period of normal function), and as generalized (occurring in all sexual situations) or situational (limited to specific contexts, such as intercourse versus masturbation).^[1] It affects approximately 1% of men with lifelong delayed ejaculation and up to 5% with acquired forms among sexually active males, with prevalence increasing with age and varying by factors such as race and comorbidities.^[3] The primary symptoms include the inability to ejaculate within a reasonable timeframe during partnered or solo sexual activity, leading to personal distress, reduced sexual satisfaction, and potential relationship strain; in severe cases, it may contribute to avoidance of intimacy or feelings of inadequacy.^[1]^[5]^[2] Complications can extend to emotional issues like anxiety or depression, interpersonal conflicts with partners, and fertility challenges due to difficulties in conception without assisted reproductive techniques.^[1]^[5] Diagnosis typically involves a detailed medical and sexual history, physical examination, and tests such as blood work for hormonal levels, neurological assessments, or vibration sensitivity testing to differentiate psychological from organic causes.^[2]^[5]^[3] Causes of delayed ejaculation are multifactorial, encompassing psychological factors such as performance anxiety, depression, relationship discord, past sexual trauma, or rigid attitudes toward sex influenced by cultural or religious beliefs, as well as physical factors including neurological damage from conditions like diabetes or multiple sclerosis, endocrine disorders such as low testosterone or hypothyroidism, surgical interventions (e.g., prostatectomy), and medications like selective serotonin reuptake inhibitors (SSRIs), antihypertensives, or antipsychotics.^[1]^[5]^[2] Substance use, including chronic alcohol consumption or recreational drugs, can also impair ejaculatory function by affecting neural pathways involved in the process.^[1]^[2] Risk factors include older age, preexisting mental health conditions, chronic illnesses, and certain lifestyle habits like excessive masturbation with atypical techniques that create a threshold mismatch during partnered sex.^[1]^[3] Treatment approaches are tailored to the underlying etiology and may include psychological interventions such as cognitive behavioral therapy or sex therapy (often involving the partner, with success rates of 70-80% after 12-18 sessions), pharmacological options like discontinuing or switching causative medications, or off-label use of drugs such as bupropion, cabergoline, or amantadine to enhance dopaminergic activity, and medical management of physical causes through hormone replacement or addressing comorbidities.^[5]^[2]^[3] For fertility concerns, techniques like penile vibratory stimulation or electroejaculation can facilitate semen retrieval.^[3] The outlook is generally positive with early intervention, particularly if the condition is medication-induced or of short duration, though no FDA-approved specific therapy exists, emphasizing the need for multidisciplinary care.^[5]^[2]^[3]

Definition and Epidemiology

Definition and Classification

Delayed ejaculation, also known as impaired ejaculation, is defined as a persistent difficulty, marked delay, or inability to ejaculate during sexual activity despite the presence of adequate sexual desire, stimulation, and arousal.^[6]^[3] This condition occurs in approximately 1% of men for lifelong cases and up to 4% for acquired cases among sexually active males.^[7]^[8] Classifications of delayed ejaculation distinguish between lifelong (primary) forms, which have been present since the onset of sexual activity, and acquired (secondary) forms, which develop after a period of normal ejaculatory function, often linked to psychological or other contributing factors.^[9]^[10] It is further categorized as generalized, occurring in all sexual contexts such as masturbation or partnered intercourse, or situational, limited to specific situations like partnered sex.^[3] The condition exists on a spectrum ranging from mild delays in ejaculation to severe delays and anejaculation, the complete absence of ejaculation.^[11]^[12] Diagnostic thresholds for delayed ejaculation, as outlined in the DSM-5 criteria for male orgasmic disorder, include a marked delay in ejaculation or infrequency/absence of ejaculation during at least 75-100% of sexual activities over a minimum of six months, causing significant distress.^[13]^[6] The ICD-11 similarly defines male delayed ejaculation as an inability to achieve ejaculation or an excessive latency despite adequate stimulation and the desire to do so, with ejaculation times often exceeding typical norms of 20-30 minutes of intravaginal stimulation.^[6]^[3]^[8]

Prevalence and Risk Factors

Delayed ejaculation affects approximately 1% to 4% of sexually active men globally, with lifelong forms occurring in about 1% and acquired forms in up to 4%.^[7] In clinical settings among men seeking treatment for sexual dysfunction, prevalence rates are higher, ranging from 4.4% to 8%.^[14]^[9] These estimates vary based on whether the condition is classified as lifelong or acquired, which influences diagnostic criteria and reporting.^[8] The condition is often underreported due to social stigma and embarrassment associated with sexual dysfunctions.^[15] Demographic trends indicate higher rates in specific populations, such as those influenced by religious or cultural inhibitions around sexuality, which can contribute to conflicted attitudes and reduced help-seeking.^[8]^[14] Key risk factors include advancing age, with delayed ejaculation becoming more prevalent in men over 50 and reaching up to 35% in those aged 70–78 years due to age-related declines in sexual function.^[7]^[16] Comorbidities such as chronic illnesses, including diabetes and multiple sclerosis, are associated with increased prevalence, as these conditions correlate with higher rates of ejaculatory dysfunction.^[1]^[17] Additionally, certain medications, such as those for high blood pressure, elevate risk without altering underlying mechanisms.^[18]

Etiology

Psychological Factors

Delayed ejaculation can arise from various psychological factors that interfere with the normal sexual response cycle, often leading to inhibitory mental states during arousal. Performance anxiety, characterized by fear of failure or inadequate performance, diverts attention from erotic stimuli and heightens stress, thereby delaying orgasm despite sufficient physical stimulation.^[3] This anxiety is particularly prevalent in situational cases, such as during fertility treatments, where men exhibit significantly higher anxiety scores compared to controls.^[9] Mental health conditions, including depression and anxiety disorders, further contribute by disrupting emotional regulation and sexual arousal; for instance, depressive symptoms are more common among men with delayed ejaculation than in the general population.^[10] Additionally, a history of sexual trauma or abuse can foster conditioned inhibitory responses, associating sexual activity with negative emotions and prolonging ejaculatory latency.^[9] Relationship dynamics play a significant role in the etiology of delayed ejaculation, where interpersonal conflicts impede emotional intimacy and sexual synchronization. Marital discord, lack of attraction to the partner, or unresolved conflicts can create psychological barriers, resulting in higher levels of relationship distress and sexual dissatisfaction reported by affected men.^[10] Feelings of hostility or fear toward the partner, often stemming from communication breakdowns or differing sexual desires, exacerbate these issues by reducing trust and arousal during partnered activity.^[8] Conditioned responses from strict upbringing or religious guilt may also manifest in relational contexts, instilling shame around sexual expression and further delaying ejaculation through internalized moral conflicts.^[19] Behavioral patterns, particularly those related to masturbation, can precondition men for delayed ejaculation in partnered sex by establishing incompatible arousal thresholds. High-frequency masturbation, often exceeding three times per week, or the use of idiosyncratic techniques that provide intense stimulation not replicable during intercourse, leads to reduced penile sensitivity and prolonged latency with a partner.^[3] This discrepancy between solo and partnered sexual experiences creates a learned inhibition, where the mental focus on specific fantasies or pressures during masturbation hinders orgasm in relational settings.^[10] Such patterns are especially evident in acquired forms of delayed ejaculation, where prior habits clash with the demands of mutual sexual activity.^[9]

Organic Factors

Organic factors contributing to delayed ejaculation involve disruptions in the neurological, hormonal, endocrine, or anatomical systems that regulate the ejaculatory reflex. These causes primarily affect the physiological processes of arousal, emission, and expulsion, often stemming from underlying medical conditions or iatrogenic effects.^[14] Neurological disorders can impair the neural pathways essential for coordinating ejaculation, including the spinal ejaculation generator and sympathetic outflow. Multiple sclerosis often leads to ejaculatory dysfunction in approximately 50% of affected men due to demyelination affecting central and peripheral nerves. Spinal cord injuries, particularly complete upper motor neuron lesions, result in ejaculatory failure in over 95% of cases, while incomplete lesions preserve the ability in about 22% of individuals by partially maintaining reflex arcs. Diabetic neuropathy, a common complication in long-standing diabetes, disrupts autonomic nerves and is associated with an inability to climax during partnered sex in 26.1% of diagnosed diabetic men, highlighting a higher prevalence in this chronic condition.^[14]^[20]^[6] Hormonal imbalances may hinder sexual response by altering libido, arousal, and the ejaculatory threshold. Low testosterone levels, or hypogonadism, are observed in 26% of men with delayed ejaculation and reduce the predisposition to ejaculate by impairing androgen-dependent maturation of ejaculatory reflexes. Thyroid dysfunction, particularly hypothyroidism, prolongs ejaculatory latency through its effects on metabolic and neural regulation of sexual function.^[14]^[20] Medications and substances frequently induce delayed ejaculation as a side effect by modulating neurotransmitter systems or suppressing neural signaling. Selective serotonin reuptake inhibitors (SSRIs), such as paroxetine, are particularly implicated, with paroxetine causing greater orgasmic delay compared to other SSRIs due to elevated serotonin levels inhibiting the ejaculatory reflex. Antipsychotics, including typical and atypical agents, contribute similarly by blocking dopamine pathways critical for sexual culmination. Alpha-blockers like tamsulosin, used for benign prostatic hyperplasia, lead to delayed ejaculation in 3.1% of users at a 0.2 mg daily dose through alpha-adrenergic antagonism that weakens emission. Opioids, such as heroin, are reported to cause delayed ejaculation in 24.5% of chronic users, with rates improving to 6.9% after switching to methadone maintenance. Chronic alcohol abuse affects up to 48% of heavy drinkers by depressing central nervous system function and altering hormonal balance.^[14]^[20]^[6] Structural issues involve physical alterations to the genital tract or pelvic innervation that obstruct or diminish ejaculatory mechanics. Prostate surgery, such as radical prostatectomy for cancer, typically abolishes antegrade ejaculation by severing nerves and removing seminal structures, whereas brachytherapy preserves it in 81.3% of cases but often with reduced volume. Pelvic nerve damage from procedures like total mesorectal excision for rectal cancer results in ejaculatory inability in 67% of men due to disruption of the hypogastric plexus. Blockages in seminal ducts, including ejaculatory duct obstruction, can impede semen flow and contribute to delayed or absent ejaculation by creating backpressure or reducing sensory feedback.^[14]^[20]

Clinical Presentation

Signs and Symptoms

Delayed ejaculation is primarily characterized by a marked prolongation of the intravaginal ejaculatory latency time (IELT), typically exceeding 25-30 minutes, or a complete inability to ejaculate despite sustained sexual arousal and a firm erection.^[3] This delay or absence of ejaculation occurs even with adequate stimulation, distinguishing it from normal variations in sexual response.^[1] The condition manifests in various sexual contexts, including partnered intercourse, solo masturbation, or both, and can be classified as generalized (occurring in all situations) or situational (limited to specific scenarios).^[3] Physically, the persistent erection without climax often leads to fatigue, discomfort, or irritation in the genital area due to prolonged friction or muscle strain during sexual activity.^[1] Some report pain or soreness following extended attempts at intercourse.^[21] These indicators typically arise after 30 minutes or more of stimulation, far beyond the average few minutes required for most men.^[5]

Associated Distress and Complications

Delayed ejaculation often generates significant personal distress for affected individuals, manifesting as frustration, embarrassment, and diminished self-esteem that undermine sexual confidence. Men experiencing this condition frequently report heightened anxiety related to performance failure and reduced subjective sexual arousal and pleasure during intercourse.^[19] Such emotional burdens can intensify over time, contributing to a cycle of avoidance and further erosion of self-worth.^[20] On a relational level, delayed ejaculation commonly leads to partner dissatisfaction and strained intimacy, with couples reporting decreased coital frequency and increased conflict over sexual expectations. Partners may feel rejected or question their attractiveness, exacerbating mutual anguish and potentially prompting avoidance of sexual activity altogether.^[19] These dynamics can erode overall relationship quality, as the persistent inability to achieve mutual satisfaction fosters resentment and emotional distance.^[3] Among the complications, delayed ejaculation may exacerbate underlying depression or precipitate new depressive symptoms, with affected men showing higher levels of psychological distress compared to those with other ejaculatory disorders.^[22] Additionally, persistent cases raise infertility concerns, as the condition hinders natural conception and often necessitates assisted reproductive techniques like sperm retrieval.^[23] In the long term, delayed ejaculation is associated with reduced quality of life, including lower mental and physical well-being scores, and elevated rates of sexual avoidance behaviors that perpetuate isolation. Studies indicate that chronic experiences heighten the risk of broader sexual disengagement, further compounding emotional and relational tolls.^[14]

Diagnosis

Diagnostic Approach

The diagnostic approach to delayed ejaculation begins with a comprehensive evaluation to identify underlying causes and confirm the diagnosis, typically involving a multidisciplinary team including urologists, endocrinologists, or mental health specialists as needed.^[24] This process emphasizes a thorough medical and sexual history, followed by targeted physical examination and selective laboratory testing to rule out organic contributors while assessing psychological elements.^[25] A detailed medical history is the cornerstone of diagnosis, focusing on the patient's sexual function to characterize the ejaculatory disorder. Clinicians inquire about the onset and duration of symptoms, frequency of sexual activity, ability to achieve ejaculation through masturbation versus partnered sex, and any situational variations (e.g., generalized or specific to certain contexts).^[20] The history also covers medication use (e.g., antidepressants or antihypertensives), substance abuse including alcohol and recreational drugs, relationship dynamics, partner perspectives on the issue, and any psychological stressors such as anxiety or past trauma, which may require screening for comorbid mental health conditions.^[25] Additionally, a review of systemic health factors like diabetes, neurological disorders, or pelvic surgeries is essential to identify potential organic etiologies.^[24] Physical examination follows to detect structural or neurological abnormalities contributing to delayed ejaculation. This includes a focused genital exam to assess the penis, testicles, and prostate for signs of infection, anatomical issues, or sensory deficits, alongside a neurological evaluation for peripheral neuropathy or spinal cord problems.^[20] While no pathognomonic findings are specific to delayed ejaculation, the exam helps reassure patients and uncover comorbidities like hypogonadism or vascular disease.^[25] Laboratory tests are ordered judiciously based on history and exam findings, rather than routinely, to investigate endocrine or metabolic causes. Common assessments include morning serum testosterone and prolactin levels to evaluate hormonal imbalances, fasting blood glucose or HbA1c for diabetes screening, and lipid profiles or electrolytes if neuropathy is suspected.^[25] If fertility concerns are present, semen analysis may be performed to assess ejaculatory volume and quality.^[24] Urinalysis can screen for underlying infections or diabetes as well.^[24] Classification of delayed ejaculation as lifelong or acquired is determined through the patient's timeline and history, aiding in etiology assessment. Lifelong delayed ejaculation is characterized by a consistent pattern of marked delay or inability to ejaculate since sexual debut, despite adequate stimulation, occurring in 75-100% of sexual encounters and causing distress for at least six months.^[20] In contrast, acquired delayed ejaculation develops after a period of normal function, often linked to new medical, psychological, or relational factors.^[25] This distinction, along with whether the delay is situational, guides further management without requiring additional specialized tools beyond standard history-taking.^[20]

Differential Diagnosis

Delayed ejaculation must be differentiated from other ejaculatory and sexual dysfunctions to ensure accurate diagnosis. Similar conditions include anejaculation, characterized by a complete inability to ejaculate despite adequate stimulation, which represents a more severe endpoint of the spectrum compared to the marked delay in delayed ejaculation.^[1] Retrograde ejaculation, where semen enters the bladder rather than exiting through the urethra, can mimic delayed ejaculation but is distinguished by the absence of seminal fluid emission during orgasm, often confirmed by post-ejaculation urinalysis showing sperm.^[3] Inhibited orgasm, or anorgasmia, involves the absence of orgasmic sensation with or without ejaculation, differing from delayed ejaculation where orgasm eventually occurs after prolonged stimulation.^[26] Overlapping disorders include erectile dysfunction, which primarily affects arousal and erection maintenance rather than the climax phase, though both may coexist; in delayed ejaculation, erections are typically preserved during the extended stimulation period.^[3] Premature ejaculation presents the opposite timing issue, with ejaculation occurring sooner than desired, and requires differentiation through patient history of latency times.^[1] Hypoactive sexual desire disorder, involving low sexual interest, can secondarily contribute to delayed ejaculation but is distinguished by the primary complaint of reduced initiation rather than climax delay.^[26] Medical conditions that mimic delayed ejaculation include hypogonadism, marked by low testosterone levels leading to reduced ejaculatory function, differentiated by laboratory confirmation of hormone deficiencies and potential improvement with testosterone replacement.^[3] Spinal cord lesions, such as those from injury or multiple sclerosis, disrupt neural pathways for ejaculation, often resulting in absent or delayed response; key differentiators include neurological exam findings and history of trauma or demyelinating disease.^[3] Medication-induced anorgasmia or delay, commonly from selective serotonin reuptake inhibitors (SSRIs) or alpha-blockers, is identified by temporal association with drug initiation and resolution upon discontinuation.^[26] Referral to urology is warranted for suspected organic causes, such as neurological or endocrinological issues, to facilitate targeted testing like hormone assays or imaging.^[25] For cases dominated by psychological factors, such as anxiety or relationship issues, referral to psychiatry or a sexual health specialist is recommended to address underlying mental health contributors.^[25]

Management

Psychological and Behavioral Therapies

Psychological and behavioral therapies for delayed ejaculation primarily address underlying mental health issues, relational dynamics, and maladaptive sexual habits that contribute to the condition, such as performance anxiety and inhibitory thought patterns.^[25] These interventions aim to enhance arousal, reduce psychological barriers, and foster healthier sexual communication without relying on pharmacological aids.^[27] Sex therapy, often guided by models like the Sexual Tipping Point, employs techniques such as sensate focus exercises to progressively build non-demand intimacy, thereby alleviating performance pressure and improving partner communication.^[27] Directed masturbation training is a core component, involving modifications to solo stimulation habits—such as changing hand dominance or incorporating fantasy aligned with partnered experiences—to bridge discrepancies between self and relational arousal.^[27] In clinical applications, these methods have demonstrated success rates exceeding 75%, with approximately 20% of men achieving intravaginal ejaculation within six weeks, particularly when motivation and relationship quality are favorable.^[27] Cognitive-behavioral therapy (CBT) targets distorted cognitions and emotional factors, including negative self-perceptions, fear of failure, or unresolved trauma, through structured exercises like cognitive restructuring and relaxation training to normalize sexual responses.^[28] Integrated with couples elements, CBT has shown an 87% success rate in resolving symptoms across 220 cases, emphasizing the role of addressing both individual and interpersonal inhibitions.^[28] Couples counseling focuses on bolstering emotional intimacy and resolving relational conflicts that exacerbate delayed ejaculation, such as mismatched sexual expectations or communication breakdowns, often incorporating meditative practices or joint sensate focus to rebuild trust.^[28] Evidence from brief interventions indicates sustained improvements in symptoms for up to 16 months post-treatment in small cohorts, highlighting the therapy's efficacy in enhancing mutual satisfaction when relational dynamics are prioritized.^[9] Behavioral strategies include scheduled sexual activities to reduce anticipatory anxiety and gradual exposure techniques, such as altering stimulation intensity or incorporating erogenous zone play, to heighten arousal thresholds progressively.^[25] Masturbatory retraining, by conditioning responses to partner-like stimuli, further supports these efforts, with cohort data showing significant enhancements in sexual function scores at six-month follow-ups.^[9]

Pharmacological Interventions

Pharmacological interventions for delayed ejaculation primarily target underlying organic causes, such as medication side effects or hormonal imbalances, through adjustments to existing treatments or the introduction of pro-ejaculatory agents.^[29] In cases where delayed ejaculation is induced by selective serotonin reuptake inhibitors (SSRIs) like sertraline or fluoxetine, which are known to prolong ejaculation latency in 11-75% of users, the first-line approach involves discontinuing the offending medication if clinically feasible or switching to alternatives with lower serotonergic activity.^[30] For instance, transitioning to bupropion, a norepinephrine-dopamine reuptake inhibitor dosed at 150-300 mg daily, has demonstrated a 25% reduction in intravaginal ejaculation latency time in small studies of 19 men with antidepressant-induced delays, thereby facilitating orgasm without exacerbating depressive symptoms.^[30] Similar adjustments for antihypertensives or other drugs contributing to ejaculatory dysfunction, such as alpha-blockers, can lead to improvements in medication-induced cases based on case series and retrospective analyses.^[29] Pro-ejaculatory drugs, often used off-label, aim to enhance dopaminergic or oxytocinergic pathways to counteract inhibitory mechanisms. Cabergoline, a dopamine D2 receptor agonist administered at 0.5 mg twice weekly, has shown efficacy in reducing prolactin levels and improving orgasmic function, with a retrospective study of 72 men reporting 69% subjective improvement in anorgasmia associated with delayed ejaculation; common side effects include nausea and potential cardiac valve fibrosis with long-term use.^[29] Amantadine, which promotes dopamine release via NMDA antagonism at doses of 100-400 mg as needed or 75-100 mg daily, alleviated SSRI-induced delays in 42% of 19 participants in a case series, though side effects such as dizziness and nausea limit tolerability.^[30] Oxytocin, administered intranasally at 16-24 IU, targets peripheral receptors to potentially augment ejaculatory reflexes, but evidence is mixed—a randomized controlled trial (RCT) of 103 men found no significant reduction in ejaculation time (p=0.53), despite anecdotal benefits in case reports; side effects are generally mild, including nasal discomfort and headache.^[3] Hormonal therapy is reserved for confirmed hypogonadism contributing to delayed ejaculation. Testosterone replacement, such as 2% topical solution applied daily, addresses low serum levels and has led to ejaculatory improvements in hypogonadal men per case studies and guidelines, though an RCT of 42 androgen-deficient individuals showed no significant overall benefit; potential adverse effects include application-site irritation, pain, and risks of erythrocytosis.^[3] Overall, pharmacological options lack FDA approval for delayed ejaculation and rely on limited evidence from small RCTs and case series, with success rates varying by etiology but generally modest (40-70% in targeted subgroups).^[29]

Other Treatments

Physical aids, such as penile vibratory stimulation (PVS) devices, offer a noninvasive approach to facilitate reflex ejaculation in men with delayed ejaculation, particularly those with secondary retarded orgasm or neurogenic causes. These devices apply vibration to the penile frenulum or glans, stimulating afferent nerves to trigger the ejaculatory reflex, and have demonstrated success in up to 72% of cases, with effects lasting at least six months in responsive patients.^[31] PVS is considered low-risk and cost-effective, making it a suitable option for cases refractory to standard therapies, though optimal protocols involve sessions of up to 10 minutes.^[3] Neuromodulation techniques, including transcutaneous electrical nerve stimulation (TENS) and sacral nerve stimulation, have been investigated for neurological cases of delayed ejaculation, such as those associated with spinal cord injury, by modulating pelvic nerve activity to enhance ejaculatory response. When PVS is ineffective, rectal probe electroejaculation (EEJ)—a form of targeted electrical stimulation—can retrieve semen in neurogenic anejaculation, achieving success rates of 80-95% for sperm collection in suitable candidates, often yielding motile spermatozoa for fertility purposes.^[3] These methods require medical supervision due to potential risks like autonomic dysreflexia in spinal injury patients. Surgical options for delayed ejaculation are rare and typically reserved for iatrogenic causes, such as post-prostatectomy nerve damage leading to ejaculatory dysfunction. Evidence for surgical interventions to restore ejaculatory function remains limited and primarily derived from studies on erectile function recovery, with no established techniques specifically for ejaculation.^[32] For fertility-focused interventions in anejaculation—a severe form of delayed ejaculation—procedures such as EEJ, percutaneous epididymal sperm aspiration (PESA), or testicular sperm extraction (TESE) enable semen retrieval for assisted reproduction, with TESE showing high success in obtaining viable sperm even without ejaculation.^[3] Lifestyle modifications, including regular exercise and balanced diet, can indirectly support treatment by addressing underlying comorbidities like obesity, diabetes, or cardiovascular disease that contribute to delayed ejaculation through vascular or neuropathic mechanisms. Evidence from broader reviews on male sexual dysfunction indicates benefits for overall sexual function, but research specifically for delayed ejaculation remains insufficient to draw firm conclusions.^[33] Emerging research as of 2025 explores alternative approaches like mindfulness-based interventions and acupuncture, though evidence remains limited and inconclusive for delayed ejaculation specifically. Mindfulness practices may reduce performance anxiety and improve sexual satisfaction in men with ejaculatory disorders, with scoping reviews suggesting potential benefits for overall sexual well-being but no robust trials targeting delayed orgasm.^[34] Similarly, acupuncture shows preliminary promise in modulating autonomic responses for sexual dysfunctions, but systematic reviews highlight insufficient high-quality data for its application in delayed ejaculation, contrasting with stronger evidence for premature ejaculation.^[35] Preliminary studies from 2024 have also explored low-dose Adderall (amphetamine/dextroamphetamine), reporting improvements in symptoms and orgasmic latency time in small cohorts, though further research is needed.^[36]

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