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Enterolith

An enterolith is a mineral concretion or stone that forms within the gastrointestinal tract, typically composed of calcium salts, bile acids, or other precipitated substances from intestinal contents.^[1] Enterolithiasis, the medical condition characterized by the presence of these concretions, arises primarily due to intestinal stasis, where slowed motility allows for the accumulation and hardening of material, and is classified as either primary (endogenously formed in the gut, often in diverticula or strictures) or secondary (migrated from elsewhere, such as gallstones entering via fistulas).^[2] This rare phenomenon in humans has a reported prevalence ranging from 0.3% to 10% in specific populations, such as those with underlying bowel disorders, and enteroliths can vary in size from millimeters to over 10 centimeters, appearing as single or multiple oval, round, or faceted masses.^[3] Predisposing factors for enterolith formation include structural abnormalities like Meckel's diverticulum, in which enterolithiasis develops in 3%–10% of cases, Crohn's disease, tuberculosis-related strictures, surgical anastomoses, or hernias that promote stasis and altered pH environments conducive to precipitation.^[3] In the proximal small bowel, enteroliths often consist of choleic acid salts derived from bile, while distal ileal ones are predominantly calcified with calcium carbonate or phosphate in an amorphous matrix.^[1] Secondary enteroliths, such as those in gallstone ileus, account for 1%–4% of small bowel obstructions and carry a higher mortality risk of 12%–27% due to complications like perforation or delayed diagnosis.^[3]^[4] Clinically, enteroliths are often incidental findings on imaging but can cause significant morbidity, including acute small bowel obstruction (as seen in idiopathic cases with stones exceeding 25 mm), hemorrhage, or fistula formation, particularly in the terminal ileum.^[2] Diagnosis typically involves radiographic or ultrasonographic detection of mobile, dense-rimmed opacities, with treatment ranging from endoscopic removal to surgical intervention, yielding low mortality rates under 3% for primary cases when managed promptly.^[2] While more commonly reported in veterinary medicine (e.g., equine colic), human enterolithiasis underscores the importance of addressing underlying stasis to prevent formation.^[3]

Definition and Pathophysiology

Definition

An enterolith is a mineral concretion or calculus that forms endogenously within the gastrointestinal tract, most commonly in the small or large intestine.^[5] These structures develop as mineral salts precipitate and accrete around a nidus, such as a foreign body or fecal material, in areas of stasis.^[6] Enteroliths are classified as primary, formed in situ within the gut (often in diverticula or strictures), or secondary, migrated from elsewhere such as gallstones entering via fistulas.^[5] Unlike gallstones (choleliths), which originate in the biliary system from concentrated bile components, or nephroliths, which form in the urinary tract from supersaturated urine minerals, enteroliths are distinctly intestinal in origin and location.^[7]^[8] This endogenous formation within the gut lumen sets enteroliths apart, as they arise from alterations in intestinal pH, microbial activity, and ion concentrations rather than systemic excretory processes.^[9] Enterolithiasis was first described in 1710 by the French physician Chomelin J.^[5]

Formation and Composition

Enteroliths develop through a process of nucleation, where mineral precipitation begins around a central nidus, such as a foreign body (e.g., wire or small ingested material) or fecal residue, in regions of intestinal stasis. This initial core serves as a scaffold for subsequent concentric layering of minerals, which accrete over time in alkaline environments where intestinal contents stagnate due to reduced motility. The formation is favored in areas with compromised peristalsis, allowing supersaturated solutions to deposit successive layers until the concretion reaches a size capable of causing obstruction.^[10]^[5] Composition varies by location and species; in humans, enteroliths often consist of calcium salts such as carbonate, phosphate, or oxalate, or bile acid salts like choleic acid, while other forms may include ammonium magnesium phosphate. These minerals precipitate in a crystalline structure, often exhibiting a laminated appearance upon cross-section, reflective of episodic deposition.^[5] Several biophysical and chemical factors influence enterolith growth, including elevated concentrations of dietary minerals in the intestinal lumen, which promote supersaturation. A pH greater than 7 is critical, as it shifts the equilibrium toward mineral insolubility, often exacerbated by dehydration that induces stasis and concentrates solutes.^[11]^[5] Enteroliths can range from millimeters to over 10 cm in diameter, with their density—often due to high mineral content—rendering them radiopaque on imaging in many instances, aiding diagnosis. Smaller concretions may remain asymptomatic, while larger ones accumulate sufficient mass to impinge on intestinal function.^[12]^[13]

Occurrence in Equines

Causes and Risk Factors

Enterolith formation in horses is multifactorial, involving interactions between diet, environment, physiology, and management practices that promote mineral precipitation in the large intestine.^[10] Primarily composed of struvite (magnesium ammonium phosphate), these concretions develop under conditions favoring supersaturation of minerals in an alkaline intestinal environment.^[14] Dietary factors play a central role, with high intake of magnesium and protein from alfalfa hay significantly increasing risk by elevating mineral availability and contributing to alkaline hindgut pH.^[10] Horses fed more than 50% alfalfa in their forage diet show markedly higher incidence, as alfalfa provides 5-7 times the magnesium needed for maintenance, promoting struvite precipitation.^[14] Low roughage diets further exacerbate stasis in the large colon, slowing digesta transit and allowing prolonged mineral accretion.^[15] Environmental and physiological contributors include dehydration or low water intake, which concentrates minerals and raises intestinal pH, while bacterial overgrowth—particularly urea-splitting bacteria like those in the genera Proteus and Staphylococcus—produces ammonia that further alkalizes the hindgut, facilitating struvite formation. Limited outdoor time (≤50% of the day) and stall confinement reduce gut motility, compounding stasis and risk.^[16] Breed predispositions are evident, with Arabians, Arabian crosses, Morgans, American Saddlebreds, Quarter Horses, and miniature horses overrepresented due to potential genetic factors affecting electrolyte transport or mineral handling.^[10] Geographic patterns highlight higher incidence in arid regions such as California, where water quality (high mineral content) and prevalent alfalfa-based feeding practices align with these risk factors; similar trends occur in Florida.^[10] Enteroliths typically affect horses aged 5-10 years, with cases rare under 2 years, suggesting cumulative exposure to predisposing conditions.^[14] Initiation often begins with a nidus, such as ingested foreign objects (e.g., nails, pebbles, bailing twine, wire, or hair) or endogenous material like fecal residue, around which layers of minerals accrete over years in the ascending colon.^[15]

Clinical Presentation and Diagnosis

Enterolithiasis in horses most commonly presents as recurrent episodes of colic due to partial or complete obstruction in the large intestine, particularly the ascending or small colon. Clinical signs include abdominal pain manifesting as pawing, rolling, sweating, or kicking at the abdomen; horses may also exhibit lethargy, decreased appetite, weight loss, or depression between episodes.^[10] Large enteroliths in the large colon often cause chronic intermittent colic, while smaller stones migrating to the small colon can lead to acute, severe pain with elevated heart rate, toxemia, and intestinal distension.^[12] Some horses remain asymptomatic until obstruction occurs or pass small stones in feces without notice.^[14] If untreated, complications such as enterolith rupture can result in peritonitis, septic shock, or intestinal necrosis, with higher risks in obstructed cases.^[10] Diagnosis relies on history of recurrent colic in at-risk breeds or regions, combined with imaging. Abdominal radiographs detect radiopaque enteroliths in 65-90% of cases, showing round or faceted densities (often 5-30 cm) in the abdomen that may shift position; triangular shapes suggest multiples.^[14] Rectal palpation can identify large colon impactions, while transabdominal ultrasound may reveal gas patterns or fluid accumulation indicative of obstruction.^[12] Definitive confirmation occurs via exploratory laparotomy, as early surgical intervention improves outcomes.^[10] Differential diagnoses include other colic causes like impactions, displacements, or parasites; enteroliths are suspected in endemic areas with compatible risk factors.^[15]

Management and Prevention

Management of equine enterolithiasis centers on surgical removal to alleviate obstruction and prevent fatal complications, as medical dissolution is ineffective. Exploratory celiotomy allows direct extraction of enteroliths from the large intestine, with success rates exceeding 90% when performed promptly before rupture or severe toxemia.^[10] Postoperative care includes fluid therapy, pain management, and monitoring for peritonitis; mortality is low (under 10%) in uncomplicated cases but rises with delays.^[14] Recurrence risk is 10-20% without dietary changes, emphasizing long-term prevention.^[12] Prevention focuses on modifiable risk factors. Dietary adjustments include limiting alfalfa to less than 50% of forage intake and substituting grass hay to reduce magnesium and protein overload; eliminate or minimize wheat bran due to its phosphorus content.^[15] Ensure daily turnout for at least 50% of the time to promote gut motility, provide constant access to clean, low-mineral water to prevent dehydration, and consider supplements like psyllium for roughage or apple cider vinegar (1-2 oz daily) to acidify the hindgut, though evidence for the latter is anecdotal.^[10] In high-risk areas like California, regular veterinary monitoring and avoiding foreign object ingestion through pasture management further mitigate incidence, which has remained stable as of 2025.^[17]

Occurrence in Humans

Causes and Associated Conditions

Enteroliths in humans are classified as primary or secondary based on their origin. Primary enteroliths form de novo within the gastrointestinal tract, typically in areas of intestinal stasis such as diverticula or strictures, and are rare, while secondary enteroliths are more common and arise due to intestinal stasis caused by strictures, diverticula such as Meckel's diverticulum, or adhesions, or migration from outside the GI tract.^[5]^[13] Several diseases are associated with enterolith formation, primarily those that promote luminal narrowing and stasis. Crohn's disease leads to strictures that impair intestinal flow, creating conditions conducive to precipitation; similarly, intestinal tuberculosis causes constrictions that facilitate enterolith development.^[5]^[13] Radiation enteritis and post-surgical alterations, such as enteroanastomoses or afferent loops, also narrow the lumen and increase risk.^[5] In children, enteroliths are rare but can occur with congenital anomalies like Meckel's diverticulum or imperforate anus, which cause abnormal bowel segments prone to stasis.^[5]^[18] Risk factors for enterolithiasis include chronic constipation, which exacerbates stasis, and diets high in minerals like calcium, potentially contributing to precipitation in susceptible individuals.^[5] Infections or bacterial overgrowth can promote an alkaline intestinal environment, further favoring stone formation.^[13] The condition accounts for less than 1% of bowel obstructions, underscoring its rarity.^[5] Pathophysiologically, intestinal stasis allows for the supersaturation and precipitation of minerals from luminal contents, most often calcium-based salts such as calcium carbonate or phosphate, rather than struvite, in stagnant segments.^[13] This process is pH-dependent, with alkaline conditions in the distal small bowel enhancing calcium salt crystallization.^[13]

Clinical Presentation and Diagnosis

Enterolithiasis in humans typically presents with symptoms related to partial or complete bowel obstruction, most commonly in the small intestine. Patients often experience intermittent colicky abdominal pain, nausea, vomiting, abdominal distension, constipation, and fever due to the fluctuating movement of the enterolith within the gastrointestinal tract. Jaundice may occur in secondary cases involving biliary migration.^[3] In the majority of symptomatic cases, acute bowel obstruction predominates, accounting for the primary clinical manifestation, while chronic presentations may involve malabsorption syndromes from bacterial overgrowth or occult gastrointestinal bleeding leading to anemia.^[19] Abdominal pain is reported in over 90% of cases, with distension in 54-84%, nausea and vomiting in 60-95%, constipation in about 55%, fever in 41%, and jaundice in 7%.^[3] If untreated, enterolithiasis can lead to serious complications, including bowel perforation, peritonitis, and sepsis, which are more frequent in small bowel involvement compared to colonic cases due to the narrower lumen and higher mobility of enteroliths in the ileum.^[20] Other potential issues include intestinal gangrene, intussusception, and hemorrhage, with perforation occurring from pressure necrosis or erosion.^[3] Diagnosis begins with plain abdominal X-rays, which detect radiopaque enteroliths (often calcium-based) in approximately 33% of cases, showing a laminated or faceted density that may change position on serial films.^[3] Computed tomography (CT) scans provide superior visualization, identifying the enterolith's location, size, and any associated stricture or obstruction in up to 80% of instances, and are particularly useful for distinguishing primary from secondary enteroliths.^[3] Endoscopy, such as colonoscopy for colonic stones or enteroscopy for small bowel, allows direct visualization and potential biopsy, while barium studies may outline filling defects if imaging is inconclusive.^[20] Differential diagnosis includes bezoars, gallstones (in ileus), tumors, or adhesions causing obstruction; enteroliths are suspected when a mobile, calcified mass is seen without prior biliary disease, and biopsy confirms underlying pathology like strictures in Crohn's disease if needed.^[3]

Management and Prevention

The management of enteroliths in humans primarily involves removal of the stone to relieve obstruction and addressing any underlying predisposing conditions to mitigate complications and recurrence. For accessible enteroliths, endoscopic techniques such as double-balloon enteroscopy (DBE) allow for minimally invasive retrieval, often using forceps, snares, or adjunctive dissolution therapies like cola infusion to fragment the stone before extraction.^[21] In cases of complete bowel obstruction or when endoscopic access is limited, surgical intervention is required, typically via enterotomy for direct stone removal or segmental bowel resection if associated with strictures or perforation; laparoscopic approaches have shown success in select patients, reducing recovery time compared to open surgery.^[22]^[23] Underlying etiologies, such as Crohn's disease, necessitate targeted therapy including anti-inflammatory medications (e.g., corticosteroids or biologics) alongside stone removal to restore intestinal motility and prevent stasis.^[24] Prognosis for isolated enterolith cases is generally favorable with prompt intervention, achieving resolution in the majority of patients and a low mortality rate of approximately 3% for primary enterolithiasis, though this rises to 8% in secondary cases complicated by comorbidities or delayed diagnosis.^[5] Recurrence remains a concern if predisposing factors like intestinal stasis are not addressed, with reported cases of repeated obstruction highlighting the need for comprehensive follow-up.^[25] Prevention strategies center on managing conditions that promote stasis, such as surgical correction of strictures or diverticula through resection or dilation, and optimizing medical therapy for chronic gastrointestinal disorders like Crohn's disease to maintain bowel patency.^[5] In at-risk patients with motility issues, measures including adequate hydration, prophylactic laxatives, and a high-fiber diet to enhance peristalsis can help reduce stone formation risk, while regular endoscopic screening is recommended for those with inflammatory bowel disease or prior surgeries.^[22]

References

[1]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221119/
[2]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703179/
[3]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273132/
[4]
Enterolithiasis - PMC - PubMed Central - NIH
Enterolithiasis or formation of gastrointestinal concretions is an uncommon medical condition that develops in the setting of intestinal stasis.Missing: definition | Show results with:definition
[5]
Single large enterolith in a cat with chronic inflammatory enteropathy
Feb 13, 2024 · Enteroliths, or intestinal calculi, are mineralised concretions within the gastrointestinal lumen. While recognised sporadically in ...Investigations · Treatment · Discussion
[6]
Gallstones vs. Kidney Stones: Differences, Symptoms, and Treatment
Dec 5, 2022 · Gallstones are deposits of digestive fluid, while kidney stones are crystals formed from chemicals in the urine. Both types of stones may pass.Missing: enterolith | Show results with:enterolith
[7]
Nephrolithiasis: What Is It, Types, Signs and Symptoms, Diagnosis
Mar 14, 2025 · Nephrolithiasis, also known as kidney stones or renal calculi, refers to the presence of stones within the kidneys.
[8]
Enterolithiasis | Radiology Reference Article | Radiopaedia.org
Sep 18, 2020 · Enterolithiasis represents the formation of dense concretions (enteroliths) within the gastrointestinal tract, typically as a consequence of intestinal stasis ...Missing: definition | Show results with:definition
[9]
Enteroliths in horses - PubMed
Many cases of enteroliths were reported in the nineteenth century but the number greatly decreased in the early twentieth century. However, in recent years ...
[10]
Enterolithiasis | School of Veterinary Medicine
Jul 29, 2019 · Enteroliths are mineral accumulations around a foreign object that form stones inside the bowel and can result in colic.
[11]
Influence of diet and water supply on mineral content and pH within ...
Enteroliths are intestinal calculi composed predominantly of struvite, a composite of magnesium ammonium phosphate, which form in the ampulla coli of the right ...Missing: chemical | Show results with:chemical
[12]
None
### Summary: Role of Bacteria in Enterolith Formation, Urease, Klebsiella, Proteus, Mechanism, Composition
[13]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9292452/
[14]
Enterolith Causing Small Bowel Obstruction: Report of a Case and ...
Jul 14, 2022 · Enteroliths range in size and number from a few millimetres to a few centimetres. ... In the event that the enterolith is retained, it may grow in ...
[15]
Enteroliths in Horses - Kentucky Equine Research
Dec 17, 2017 · Some theories link phosphorus-rich wheat bran, water with a high content of dissolved minerals, or iron-laden feeds to enterolith formation.Missing: mechanism chemical
[16]
Enteroliths in Horses: Causes and Prevention
May 24, 2025 · Enteroliths are a type of foreign body that can be found in horses' intestines and are one possible cause of colic, or abdominal pain.
[17]
Risk factors for enterolithiasis among horses in Texas - PubMed
Horses that were fed alfalfa hay, spent < or = 50% of time outdoors, or were Arabian or miniature breeds had an increased risk of developing enteroliths.
[18]
Enterolith from Small Bowel Diverticulum as an Uncommon Cause ...
Nov 28, 2022 · Small bowel diverticulosis predisposes enterolith formation due to altered luminal propagation and peristaltic function causing stasis as well ...
[19]
https://www.gavinpublishers.com/article/view/enterolith-from-small-bowel-diverticulum-as-an-uncommon-cause-of-acute-small-bowel-obstruction-and-literature-review
[20]
Enterolith Treated with a Combination of Double-Balloon Endoscopy ...
Mar 15, 2023 · In most cases, surgical management is the main treatment for enteroliths because they are not discovered until the occurrence of clinical ...
[21]
Enterolith causing small bowel obstruction | CEG - Dove Medical Press
Jul 14, 2022 · True primary enteroliths are formed from chemical elements that are already present in the bowel in anatomically compromised areas of stasis, ...Missing: mechanism | Show results with:mechanism
[22]
An unusual case of small intestinal obstruction secondary to a large ...
Jul 13, 2023 · Clinical presentation ranges from intestinal colic, intestinal obstruction, gangrene, perforation, bleeding, or iron deficiency anemia. ...
[23]
Crohn's Disease With Enterolith Treated Laparoscopically - PMC - NIH
The most definitive treatment for Crohn's enterolith is segmental resection with stone removal. This has mostly been done through open laparotomy, but there has ...Missing: strategies | Show results with:strategies
[24]
Recurrent Enterolithiasis Small Bowel Obstruction: A Case Seldom ...
Recurrent enterolithiasis of the small bowel is a rare phenomenon and may present with recurrent obstruction. Definitive preoperative diagnosis is not ...Missing: frequency | Show results with:frequency
[25]
Robotic Surgery Drives Rise in Minimally Invasive Colorectal ...
Mar 3, 2025 · The rise of robotic-assisted surgery has been a key factor in the growing adoption of minimally invasive surgery (MIS) for patients with colorectal cancer.
[26]
Intestinal obstruction due to Meckel's enterolith - PubMed
Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract and represents a persistent remnant of the omphalomesenteric duct.