Interstate 44
Interstate 44 (I-44) is an east–west Interstate Highway spanning 636 miles (1,024 km) across the central United States. Its western terminus is at a junction with U.S. Route 277, U.S. Route 281, U.S. Route 287, and U.S. Route 82 in Wichita Falls, Texas, while its eastern terminus is at I-70 in St. Louis, Missouri.[1] The route primarily travels northeast through rural and urban areas, connecting the southern Great Plains to the Midwest. In Texas, I-44 consists of a brief 15.4-mile (24.8 km) segment serving as a connector from the Oklahoma state line into Wichita Falls.[2] The majority of the highway lies in Oklahoma, where it links key cities including Lawton, Oklahoma City, and Tulsa, while incorporating tolled sections such as the H.E. Bailey Turnpike, Will Rogers Turnpike, and Turner Turnpike. In Missouri, I-44 extends approximately 290 miles from the Oklahoma border near Joplin, passing through Springfield and other communities before reaching St. Louis, and was constructed as one of the nation's earliest freeways, with work beginning in 1956 and completion in 1966.[3] I-44 functions as a critical commercial trucking corridor, carrying over 9,100 trucks daily on portions of the route and facilitating connections to major interstates like I-35, I-40, I-49, I-55, and I-70. It supports regional economic activity by providing efficient access between manufacturing hubs, energy production areas, and distribution centers across the three states.[3] Ongoing infrastructure improvements, including bridge rehabilitations and capacity expansions, address growing traffic demands and enhance safety and resilience along the corridor.[4]Route description
Texas
Interstate 44 in Texas is a short 15.4-mile (24.8 km) freeway connecting the Oklahoma state line to Wichita Falls. It begins at a junction with US 82, US 277, US 281, and US 287 in western Wichita Falls and heads northeast, known locally as the Central Freeway. The route provides access to downtown Wichita Falls, Sheppard Air Force Base, and Wichita Falls Municipal Airport via Spur 325 and FM 890. Continuing north, it passes through suburban areas and enters Burkburnett as the Red River Expressway, with interchanges for SH 240 and local streets, before crossing the Red River into Oklahoma. All interchanges are toll-free and generally lack dedicated auxiliary lanes.[2]Oklahoma
Interstate 44 traverses 328 miles (528 km) diagonally across Oklahoma from the Texas state line near Grandfield to the Missouri border near Miami, serving as a major artery linking rural and urban centers. Starting as the tolled H.E. Bailey Turnpike, it passes through Walters, Lawton (with access to Fort Sill and local business districts via US 281 Bus. and US 62), Chickasha, and Tuttle before reaching Oklahoma City. In the capital, I-44 is toll-free and concurrent with I-35 north of the city and I-240 southeast, intersecting I-40 and providing urban access via exits to downtown and the State Capitol. Northeast of Oklahoma City, the tolled Turner Turnpike begins near Luther, passing Chandler, Stroud, Bristow, and Sapulpa en route to Tulsa. A new interchange at Exit 203 for SH-66 near Kellyville opened in December 2024 to improve local access.[5] In Tulsa, the route is again toll-free, incorporating the unsigned I-444 and intersecting I-244, US 75, and US 169 while serving Oral Roberts University and St. Francis Hospital. East of Tulsa, the tolled Will Rogers Turnpike resumes near Catoosa, passing Claremore, Vinita (with a service plaza at the Will Rogers Archway), and Miami before reaching the state line. The turnpikes offer PikePass electronic tolling discounts.[6][7][8]Missouri
Interstate 44 in Missouri spans approximately 293 miles (472 km) from the Oklahoma state line near Joplin to its eastern terminus at Interstate 70 in downtown St. Louis, featuring over 80 numbered interchanges, all toll-free.[3] The route includes business loop tie-ins in cities like Joplin, Springfield, Lebanon, Rolla, and Sullivan for local access, as well as overlaps with former U.S. Route 66 alignments in several areas. Key junctions include the connection to Interstate 49 near Joplin, U.S. Route 65 in Springfield, and the merge with Interstate 55 in St. Louis, where the Poplar Street Bridge serves as the final approach across the Mississippi River.[9][10]History
Planning and designation
Interstate 44 was established as part of the 41,000-mile Interstate Highway System authorized by the Federal-Aid Highway Act of 1956, which provided federal funding for a nationwide network of controlled-access highways to improve national defense and commerce.[11] The route's precursor was designated as Superhighway 44 in the original 1947 plan announced by the Bureau of Public Roads, outlining an initial 37,681 miles of the system connecting major population centers across the central United States.[12] Planning for Interstate 44 involved coordination between the American Association of State Highway Officials (AASHO, now AASHTO) and the Federal Highway Administration's predecessor, the Bureau of Public Roads, which approved the general alignment in 1957 to link the southern Great Plains with the Midwest. In Texas, the segment was envisioned as a short connector of approximately 14 miles near Wichita Falls to tie into existing routes, reflecting its role as a brief extension rather than a major traversal.[13] Oklahoma's planning leveraged pre-existing turnpikes constructed in the early 1950s, such as the Turner Turnpike opened in 1953 between Oklahoma City and Tulsa, to accelerate integration into the Interstate network.[14] Missouri prioritized early development, positioning segments along former U.S. Route 66 for rapid advancement under the new federal program.[15] Designation of the route as Interstate 44 began with signage on Oklahoma's Turner and Will Rogers Turnpikes in 1958, marking the first Interstate labeling in the state and retroactively incorporating these toll facilities into the system for federal aid eligibility.[14] The full numbering and alignment were finalized during the 1960s as construction progressed and state plans aligned with federal standards, establishing endpoints at Wichita Falls, Texas, and St. Louis, Missouri, for a total length of 636 miles (1,024 km). Key early milestones included Missouri awarding its first Interstate contracts on August 2, 1956, for 13.3 miles in Laclede County along what became I-44, making it the inaugural project under the 1956 Act nationwide.[15] The Turner Turnpike's 1953 completion was later retro-designated as the core of I-44 in Oklahoma, exemplifying how existing infrastructure shaped the route's development.[14]Construction
The construction of Interstate 44 (I-44) spanned the late 1950s to the early 1970s, with segments in Texas, Oklahoma, and Missouri developed in phases that largely paralleled or upgraded existing roadways. In Texas, the 15-mile segment from Wichita Falls northward to the Oklahoma state line was built between 1959 and 1960 as part of early Interstate efforts, connecting to U.S. Highway 277 and facilitating cross-state travel. This short stretch encountered minimal terrain issues compared to other sections but required coordination with local urban infrastructure in Wichita Falls. In Oklahoma, much of I-44 utilized pre-existing turnpikes from the 1950s, including the Turner Turnpike (opened May 16, 1953, between Oklahoma City and Tulsa) and the Will Rogers Turnpike (opened June 28, 1957, from Tulsa to the Missouri line), which were designated as I-44 on July 14, 1958, primarily for signage purposes without major reconstruction at the time. Connections in the 1960s, such as the Skelly Drive bypass in Tulsa (opened November 21, 1958), involved urban adjustments to link these turnpikes seamlessly, though they caused temporary disruptions to local traffic patterns in the growing city. The H.E. Bailey Turnpike extension from Lawton to Oklahoma City opened on April 23, 1964, completing the state's primary I-44 corridor. Missouri's construction of I-44, the longest segment at over 290 miles, began earliest and faced the most significant engineering hurdles due to the state's diverse topography. The first Interstate contracts nationwide were awarded on August 2, 1956, to the Koss Construction Company for 13.3 miles of concrete pavement along U.S. 66 in Laclede County (now part of I-44), costing $1.1 million and marking Missouri's pioneering role in the system. Work progressed rapidly through the 1960s, with the core Ozarks section—from Joplin to near Rolla—completed by 1966, navigating the rugged Springfield and Salem Plateaus characterized by fault zones, sinkholes, and steeply dipping dolomites and limestones. The mountainous terrain demanded extensive cuts through formations like the Gasconade Dolomite (mileages 157–174) and Jefferson City Dolomite (mileages 104.3–249.15), some reaching depths of 310 feet, as well as stabilization against landslides and unstable shale layers; major bridges spanned deep valleys, including the Big Piney River (mileages 165.7 and 167.0–167.8), Gasconade River (mileage 143.1), and Meramec River (mileages 264.7, 266.5, and 276.0), often over faulted bedrock like the Chesapeake Fault (mileage 54.2, with a 150-foot throw). Urban challenges in St. Louis involved demolitions and rerouting through densely populated areas, exacerbating community disruptions during the extension via the Poplar Street Bridge (completed 1967). The final St. Louis segment, from I-55 to Laclede Station Road, opened on December 19, 1972, fully connecting I-44 coast-to-coast. By 1966, Missouri had completed the bulk of its rural Interstate routes, though urban extensions including I-44 in St. Louis opened in 1972. Missouri declared its Interstate system complete in 1966, becoming the first state to finish all assigned routes, though the I-44 urban extension extended into 1972. Overall costs for I-44 construction, based on federal obligations through 1989, totaled approximately $362 million in Missouri, $55 million in Oklahoma, and a smaller share in Texas as part of broader state investments, reflecting the era's emphasis on federal-state partnerships under the 1956 Federal-Aid Highway Act. These figures underscore the scale of the project, with Missouri's portion alone representing a substantial investment in overcoming Ozark geology and urban integration.Expansions and improvements
Following the completion of Interstate 44's original construction in the early 1970s, the Missouri Department of Transportation (MoDOT) invested in bridge replacements and rehabilitations across the Ozarks region during the 1980s and 2000s to address deterioration of structures built in the 1960s, with ongoing maintenance efforts documented in the state's 2008 Purpose and Need Study.[3] In Oklahoma, the Oklahoma Turnpike Authority modernized toll plazas along I-44 sections in the 2010s, transitioning to cashless PlatePay tolling, with the H.E. Bailey Turnpike (a portion of I-44) fully converting by July 2022 to improve traffic flow and reduce congestion.[16] Missouri's Forward 44 initiative, originating from the 2008 Purpose and Need Study that identified capacity and safety deficiencies along the corridor, has guided recent rehabilitation efforts.[3] A key project is the $70.7 million widening of I-44 to six lanes in the Springfield area from Kansas Expressway (Route 13) to U.S. Route 65, which began construction in early 2025 and is expected to conclude by May 2027, including bridge replacements and pavement upgrades to enhance mobility.[17] Additionally, a multi-phase $100 million rehabilitation of 52 miles of I-44 in Phelps and Crawford counties—from west of Rolla to Cuba—started in April 2022 and continued into 2024, focusing on resurfacing, shoulder widening, and bridge repairs to extend service life.[18] In the Joplin area, a proposed $727 million allocation in the Missouri House's 2024 budget aims to widen and reconstruct I-44 from the Fidelity interchange south of Carthage to Rolla, addressing freight and commuter demands.[19] As of 2025, significant updates include the Oklahoma Department of Transportation's $252 million reconfiguration of the I-44/U.S. 75 interchange in Tulsa—locally dubbed "Traffic Henge"—which began on April 7, 2025, involving new flyover ramps, bridge reconstructions over the Arkansas River, and frontage road improvements to eliminate the complex concrete supports and reduce weaving conflicts.[20] In Missouri, a $20 million environmental study initiated in early 2024 under the Forward 44 program evaluates corridor-wide impacts beyond funded widenings, incorporating public input and validating the 2008 study's findings for future enhancements from near St. Louis to the Oklahoma border.[21] Looking ahead, Missouri's long-term transportation plans, including the Fiscal Year 2026-2030 Statewide Transportation Improvement Program, outline potential full reconstructions of aging I-44 segments by the 2030s to accommodate projected traffic growth and structural needs.[22] In Oklahoma, the Turnpike Authority implemented toll rate increases averaging 1 cent per mile starting January 1, 2025—with 15-20% hikes on I-44 corridors like the Will Rogers and H.E. Bailey Turnpikes—followed by planned 6% inflationary adjustments every two years to fund ongoing maintenance and expansions.[23]Junction list
Texas
The Texas portion of Interstate 44 features a series of interchanges primarily serving the urban area of Wichita Falls, with all exits being toll-free and lacking dedicated auxiliary lanes.[24]| Exit number | Milepost | Locations | Destinations | Notes |
|---|---|---|---|---|
| – | 0.00 | Wichita Falls | US 277 / US 281 / US 287 south – Jacksboro, Fort Worth | Western terminus; beginning of I-44 |
| 1 | 0.32 | Wichita Falls | FM 369 (Southwest Parkway) | Access to local suburban areas; partial interchange with no northbound entrance from some directions |
| 2 | 1.80 | Wichita Falls | Spur 325 – Sheppard AFB | Direct access to Sheppard AFB; diamond interchange |
| 3A | 3.40 | Wichita Falls | Spur 325 – Wichita Falls Municipal Airport | |
| 3B | 4.30 | Wichita Falls | US 287 north – Amarillo | End of US 287 concurrency with I-44; Spur 325 provides military base access |
| 4 | 4.70 | Wichita Falls | Kell Blvd. / FM 890 | Access to local areas and airport |
| 5 | 12.20 | Burkburnett | TX 240 | Connection to Burkburnett and local roads; eastbound exit and westbound entrance |
| – | 15.40 | Wichita Falls | Oklahoma state line | Eastern terminus of I-44 in Texas |
Oklahoma
| Exit | Mile | Locations | Destinations | Notes |
|---|---|---|---|---|
| 1 | 0.00 | Grandfield | OK-36 South – Grandfield, Devol | H.E. Bailey Turnpike begins (tolled) |
| 5 | 4.95 | Randlett | US-70 West – Randlett; US-277/US-281 North – Wichita Falls | |
| 20 | 19.50 | Walters | OK-5 – Walters | Service plaza (Elmer Graham Plaza) nearby |
| 30 | 29.80 | Geronimo | US-277/US-281 South – Geronimo; OK-36 – Faxon, Lawton | |
| 33 | 32.50 | Lawton | Bus. US-281 (11th St.) – Lawton | |
| 36A | 35.80 | Lawton | OK-7 East – Duncan; Lee Blvd. | |
| 36B | 36.00 | Lawton | Lee Blvd. West | Westbound only |
| 37 | 36.50 | Lawton | Gore Blvd. – Lawton | |
| 38 | 37.50 | Lawton | NW Cache Rd. – Lawton | Added from standard lists |
| 40A | 39.50 | Lawton | NE Rogers Lane; US-62 West – Cache, Altus | Eastbound only |
| 40B | 39.80 | Lawton | US-62 East – Lawton | Westbound only |
| 41 | 40.50 | Fort Sill | Ft. Sill Key Gate | |
| 45 | 44.50 | Medicine Park | OK-49 West – Medicine Park, Carnegie | |
| 46 | 45.50 | Elgin | US-62 East; US-277/US-281 North – Elgin, Apache, Anadarko | Eastbound only |
| 53 | 52.50 | Fletcher | US-277 North – Elgin, Fletcher, Sterling | |
| 62 | 61.50 | Cyril | Local roads – Fletcher, Cyril, Sterling | Westbound only |
| 80 | 79.50 | Chickasha | US-81 North – Chickasha, El Reno | Service plaza nearby |
| 83 | 82.50 | Chickasha | US-62 West – Chickasha, Anadarko | |
| 99A | 98.50 | Tuttle | H.E. Bailey Spur East – Blanchard, Norman | Unmarked |
| 99B | 98.70 | Tuttle | OK-4 North – Tuttle, Mustang, Yukon | Unmarked |
| 107 | 106.50 | Newcastle | US-62 West; US-277 South – Newcastle, Blanchard | Toll booth nearby |
| 108 | 107.50 | Tuttle | OK-37 West – Tuttle, Minco | |
| 108A | 107.80 | Newcastle | Frontage Rd. | Westbound only |
| 109 | 108.50 | Oklahoma City | SW 149th St. | |
| 110 | 110.00 | Moore | OK-37 East; SW 134th St. – Moore | |
| 111 | 111.00 | Oklahoma City | SW 119th St. | |
| 112 | 112.00 | Oklahoma City | SW 104th St. | |
| 113 | 113.00 | Oklahoma City | SW 89th St. | |
| 114 | 114.00 | Oklahoma City | SW 74th St. | |
| 115 | 115.00 | Oklahoma City | I-240 East; US-62 East; OK-3 East – Ft. Smith | |
| 116A | 116.20 | Oklahoma City | SW 59th St. | |
| 116B | 116.50 | Oklahoma City | Airport Rd.; OK-152 West | |
| 117A | 117.00 | Oklahoma City | SW 44th St. | Eastbound |
| 117B | 117.20 | Oklahoma City | SW 44th St. | Westbound |
| 118 | 118.00 | Oklahoma City | SW 29th St. | |
| 119 | 119.00 | Oklahoma City | SW 15th St. | |
| 120A | 120.00 | Oklahoma City | I-40 West – Amarillo | |
| 120B | 120.20 | Oklahoma City | I-40 East – Ft. Smith | Key junction: I-40 (exit 150 on I-40) |
| 121A | 121.00 | Oklahoma City | NW 10th St. – Fair Park | Eastbound only |
| 121B | 121.20 | Oklahoma City | NW 10th St. | Westbound |
| 122 | 122.00 | Oklahoma City | NW 23rd St. | |
| 123A | 123.00 | Oklahoma City | NW 36th St. | Eastbound only |
| 123B | 123.20 | Oklahoma City | OK-66 West; OK-74 North – Warr Acres, Bethany | |
| 124 | 124.00 | Oklahoma City | N. May Ave. | |
| 125A | 125.00 | Oklahoma City | N. Penn Ave. | |
| 125B | 125.20 | Oklahoma City | Classen Blvd. | |
| 125C | 125.40 | Oklahoma City | OK-3A (Northwest Expressway) | Westbound only |
| 126 | 126.00 | Oklahoma City | Western Ave. | |
| 127 | 127.00 | Oklahoma City | I-235 South; US-77 – Downtown, Edmond | Key junction: I-35 nearby (duplex ends) |
| 128A | 128.00 | Oklahoma City | Lincoln Blvd. – State Capitol | |
| 128B | 128.20 | Oklahoma City | Kelley Ave. | |
| 129 | 129.00 | Oklahoma City | M.L. King Ave. | |
| 130 | 130.00 | Oklahoma City | I-35 South – Dallas | Key junction: I-35 (exit 39 on I-35) |
| 134 | 134.00 | Oklahoma City | Wilshire Blvd. | I-35 duplex |
| 135 | 135.00 | Oklahoma City | Britton Rd. | I-35 duplex |
| 136 | 136.00 | Oklahoma City | Hefner Rd. | I-35 duplex |
| 137 | 137.00 | Oklahoma City | NE 122nd St. | I-35 duplex |
| 138 | 138.00 | Oklahoma City | I-35 North – Wichita; I-44 East – Tulsa | Split from I-35 |
| 146 | 145.50 | Luther | Hogback Rd./Main St. – Luther, Jones | Westbound on/eastbound off |
| 149 | 148.50 | Luther | Kickapoo Turnpike – Harrah, Jones | |
| 150 | 150.00 | Oklahoma City | I-40 – Amarillo, Ft. Smith | Key junction: I-40; toll section begins |
| 158 | 157.50 | Wellston | OK-66 East – Wellston, Chandler | Turner Turnpike |
| 166 | 165.50 | Chandler | OK-18 – Chandler, Cushing | Service plaza (MM 169) |
| 179 | 178.50 | Stroud | OK-99 – Stroud, Drumright | |
| - | 182.00 | - | Toll Plaza | Cars $3.50 (PikePass discount) |
| 196 | 195.50 | Bristow | OK-48; OK-66 – Bristow, Lake Keystone | |
| 211 | 210.50 | Kellyville | OK-33 – Kellyville, Sapulpa; Drumright (westbound) | Diamond interchange |
| 215 | 214.50 | Sapulpa | OK-97 – Sapulpa, Sand Springs | |
| 218A | 217.50 | Sapulpa | OK-66 West – Sapulpa | Westbound on/eastbound off |
| 218B | 218.00 | Jenks | Creek Turnpike East – Jenks, Broken Arrow | Eastbound only |
| 221 | 220.50 | Tulsa | SH-66 West – Sapulpa | Westbound on/eastbound off |
| 222A | 221.50 | Tulsa | 49th W. Ave. | |
| 222B | 222.00 | Tulsa | 55th Pl. | Eastbound only |
| 223A | 223.00 | Tulsa | I-244 East – Downtown Tulsa | Key junction: I-244 |
| 223B | 223.20 | Tulsa | 51st St. | Westbound only |
| 223C | 223.50 | Tulsa | 33rd W. Ave. | |
| 224 | 224.00 | Tulsa | US-75 – Okmulgee, Bartlesville | Unsigned I-444 begins/ends here |
| 225 | 225.00 | Tulsa | Elwood Ave. | Westbound only |
| 226A | 226.00 | Tulsa | Riverside Dr. | |
| 226B | 226.20 | Tulsa | Peoria Ave. | |
| 227 | 227.00 | Tulsa | Lewis Ave. – Oral Roberts University | |
| 228 | 228.00 | Tulsa | Harvard Ave. | |
| 229 | 229.00 | Tulsa | Yale Ave. – St. Francis Hospital | |
| 230 | 230.00 | Tulsa | Sheridan Rd.; 41st St. | |
| 231 | 231.00 | Tulsa | US-64; OK-51 – Sand Springs, Broken Arrow | |
| 232 | 232.00 | Tulsa | Memorial Dr.; E. 31st St. | Westbound only |
| 233 | 233.00 | Tulsa | E. 21st St. | Eastbound only |
| 234A | 234.00 | Tulsa | US-169 North – Owasso | |
| 234B | 234.20 | Tulsa | Garnett Rd. | |
| 235 | 235.00 | Tulsa | E. 11th St. | |
| 236 | 236.00 | Tulsa | 129th E. Ave. | |
| 238 | 238.00 | Tulsa | 161st E. Ave. | |
| 240A | 240.00 | Catoosa | OK-167 (193rd E. Ave.) | |
| 240B | 240.20 | Catoosa | 193rd E. Ave. | Westbound |
| 241 | 241.00 | Catoosa | OK-66 East – Catoosa, Claremore | Will Rogers Turnpike begins (tolled) |
| 248 | 247.50 | Verdigris | OK-266 West – Port of Catoosa | |
| 252 | 251.50 | Claremore | SH-20 (Flint Rd.) – Claremore | |
| 255 | 254.50 | Claremore | OK-20 – Claremore, Pryor | |
| 269 | 268.50 | Adair | OK-28 – Adair, Chelsea, Grand Lake | Westbound on/eastbound off |
| 283 | 282.50 | Big Cabin | US-69 – Big Cabin | |
| - | 287.00 | Vinita | Vinita Toll Plaza | Mainline toll plaza; cars $4.25 (PikePass discount) |
| 289 | 288.50 | Vinita | US-60; SH-66 – Vinita | Will Rogers Archway service plaza nearby |
| 302 | 301.50 | Afton | US-59; US-60 – Afton, Fairland, Grove | |
| 313 | 312.50 | Miami | OK-10 – Miami | Key junction |
| - | 327.98 | - | Missouri state line | End of Oklahoma segment |
Missouri
Interstate 44 in Missouri spans approximately 293 miles (472 km) from the Oklahoma state line near Joplin to its eastern terminus at Interstate 70 in downtown St. Louis, featuring over 80 numbered interchanges, all toll-free.[3] The route includes business loop tie-ins in cities like Joplin, Springfield, Lebanon, Rolla, and Sullivan for local access, as well as overlaps with former U.S. Route 66 alignments in several areas. Key junctions include the connection to Interstate 49 near Joplin, U.S. Route 65 in Springfield, and the merge with Interstate 55 in St. Louis, where the Poplar Street Bridge serves as the final approach across the Mississippi River. The table below lists selected major exits from west to east, with mileposts approximated based on sequential numbering.[9][10]| Exit | Destinations | Location | Notes |
|---|---|---|---|
| 1 | US 400 West / US 166 West – Baxter Springs, Kansas | Joplin | Western terminus in Missouri; continuation from Oklahoma. |
| 8 | US 71 Business South / Range Line Road | Joplin | Access to Joplin business district; near I-44 Business Loop. |
| 11A-B | MO 249 / I-49 / US 71 | Joplin | Major interchange where I-49 terminates at I-44.[10] |
| 46 | MO 39 / MO 265 – Mount Vernon, Aurora | Mount Vernon | Rural access southeast of Springfield. |
| 61 | Missouri PP / Missouri K | Bois D'Arc | Local rural connector. |
| 72 | MO 266 / I-44 Loop / Chestnut Expressway | Springfield | I-44 Business Loop tie-in; urban access in Springfield. |
| 75 | US 160 West | Springfield | Overlap with historic Route 66. |
| 77 | MO 13 / Kansas Expressway – Bolivar | Springfield | Northern access to Springfield. |
| 80 | I-44 Business / Glenstone Avenue | Springfield | Business loop for downtown Springfield. |
| 82 | US 65 | Springfield | Key junction with US 65 north to Branson and south to Little Rock.[28] |
| 88 | MO 125 – Fair Grove, Strafford | Strafford | Access to northern suburbs of Springfield. |
| 100 | MO 38 / Missouri W | Marshfield | Rural interchange. |
| 113 | Conway | Conway | Local services. |
| 127 | I-44 Business / Morgan Road / Elm Street | Lebanon | Western tie-in to Lebanon business loop. |
| 130 | I-44 Business / Elm Street / Missouri MM | Lebanon | Eastern tie-in to Lebanon business loop. |
| 153 | MO 17 – Buckhorn | Waynesville | Near Fort Leonard Wood. |
| 159 | I-44 Business Loop | St. Robert | Access to St. Robert and Fort Leonard Wood. |
| 161 | Missouri Y / I-44 Spur – Fort Leonard Wood | St. Robert | Military base access. |
| 163 | MO 28 – Dixon | St. Robert | Local rural route. |
| 184 | I-44 Business East / US 63 South | Rolla | Western tie-in to Rolla business loop. |
| 186 | US 63 North – Jefferson City | Rolla | Major north-south route. |
| 195 | MO 68 | St. James | Wine country access. |
| 208 | MO 19 – Cuba, Owensville | Cuba | Historic Route 66 town. |
| 218 | Missouri C / Missouri J / Missouri N | Bourbon | Rural connectors. |
| 225 | MO 185 North / Missouri D | Sullivan | I-44 Business Loop tie-in in Sullivan. |
| 240 | MO 47 – St. Clair, Union | St. Clair | Access to Union area. |
| 247 | Missouri O / US 50 West / Missouri At – Union, Jefferson City | Union | Overlap with US 50. |
| 256 | I-44 Business | Pacific | Western tie-in to Pacific business loop. |
| 261 | I-44 Business | Pacific | Eastern tie-in to Pacific business loop. |
| 272 | MO 141 – Fenton, Valley Park | Valley Park | Suburban St. Louis access. |
| 274A | Bowles Avenue | Fenton | Local suburban exit. |
| 274B | Mraz Lane | Fenton | Local suburban exit. |
| 277B | US 61 / US 67 | St. Louis | Southern St. Louis access. |
| 280 | Elm Avenue | St. Louis | Final independent exit before I-55 merge; approach to Poplar Street Bridge.[29] |
| 282 | Laclede Station Road / Murdoch Avenue | St. Louis | Urban access. |
| 286 | Hampton Avenue | St. Louis | Southern city neighborhoods. |
| 287B | Vandeventer Avenue | St. Louis | Central city access. |
| 288 | Grand Boulevard / Louisiana Avenue | St. Louis | Near Forest Park. |
| 289 | Jefferson Avenue | St. Louis | Access to Lafayette Square. |
| 290B | Lafayette Avenue / Route 100B | St. Louis | Downtown approach. |
| 290C | Park Avenue | St. Louis | Near Busch Stadium. |
| 291B | I-70 West / Memorial Drive | St. Louis | Eastern terminus preparation. |
| 292 | 12th Street / Poplar Street | St. Louis | Last exit before Poplar Street Bridge and I-70 terminus; merges with I-55 / I-64. |