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Laura Deming

Laura Deming is an American venture capitalist and former researcher who founded The Longevity Fund in 2011, the first venture capital firm dedicated exclusively to investing in biotechnology companies developing therapies to address aging biology and extend human healthspan.^[1]^[2] Enrolled at MIT at age 14 to study physics and biology, she later withdrew after sophomore year to accept a Thiel Fellowship, which awarded her $100,000 at age 17 to pursue full-time work in longevity research and investment.^[3]^[4] Her early scientific contributions included laboratory experience in aging mechanisms and co-authoring papers on cancer dependencies, such as the role of lactate dehydrogenase B in KRAS-driven lung adenocarcinomas.^[5] Deming co-founded age1 in 2023 as an evolution of The Longevity Fund, focusing on early-stage funding for contrarian biotech founders, with portfolio companies achieving initial public offerings and advancing to clinical trials in longevity interventions.^[6]^[7] She also serves as CEO and co-founder of Until Labs, continuing her emphasis on translational biology to mitigate age-related decline.^[8]

Early Life and Influences

Childhood in New Zealand

Laura Deming was born in 1994 in New Zealand to American father John Deming, an investment manager, and Korean mother Tabitha Deming, who primarily raised the children.^[9]^[10] She grew up alongside her brother Trey in a homeschooling environment that eschewed traditional schooling in favor of self-directed learning, with her parents emphasizing exploration over structured curricula.^[11]^[9] This approach, influenced by her father's admiration for scientists as societal heroes, encouraged empirical curiosity without rigid academic timelines, allowing Deming to pursue interests like mathematics and literature independently from an early age.^[11] An early catalyst for her focus on biology emerged during her childhood when her maternal grandmother, Bertie, visited the family and suffered visible decline from age-related conditions, including severe arthritis that made simple tasks like buttoning a shirt excruciatingly slow and painful.^[12]^[10] Witnessing this prompted Deming to begin informal self-study into aging processes through accessible books, marking an initial, personal confrontation with human frailty rather than a formalized scientific pursuit.^[12] By age 12, seeking advanced opportunities unavailable in New Zealand's educational landscape, Deming relocated to the United States to commence graduate-level coursework at the University of California, San Francisco, while her parents had initially intended to remain in New Zealand.^[9]^[13] This transition reflected the limitations of her isolated, resource-constrained homeschooling setup for pursuing specialized research, underscoring a pragmatic shift driven by access to institutional labs and mentors rather than innate precocity alone.^[14]

Development of Interest in Aging Biology

Deming's interest in aging biology emerged at age eight, spurred by the illness of a grandparent, which prompted her to investigate the underlying biological processes driving age-related decline.^[15] Homeschooled in an environment that afforded complete freedom for self-directed inquiry, she began systematically exploring scientific literature on aging during her pre-teen years, prioritizing empirical observations over anecdotal health narratives.^[16] Her early studies centered on key mechanisms of cellular deterioration, including telomere shortening—which limits cell replication—and cellular senescence, where damaged cells persist and secrete inflammatory signals rather than undergoing programmed death.^[17] Deming recognized aging not as an inexorable program but as the accumulation of repairable damage, such as DNA errors and protein misfolding, evidenced by lifespan extension in model organisms like nematodes (C. elegans) and mice through targeted interventions like caloric restriction or genetic modifications.^[18] This perspective, grounded in first-principles analysis of causal pathways, led her to hypothesize that biological engineering could reverse such damage, diverging from correlational approaches dominant in popular discourse.^[17] By ages 10 to 12, Deming's intellectual evolution emphasized testable predictions derived from organism-level data, such as how mutations in genes like daf-2 in worms extend lifespan by altering insulin signaling, informing her conviction that aging's hallmarks were addressable via direct molecular repairs rather than symptomatic palliation.^[18] This proto-scientific framework rejected fatalistic acceptance of decline, instead advocating causal interventions to restore youthful function, setting the stage for her subsequent experimental pursuits.^[17]

Education and Initial Research

Homeschooling and Early Scientific Training

Deming was homeschooled in New Zealand during her early years, a setting that supported self-directed learning and flexibility in pursuing scientific interests without the rigid structure of conventional schooling.^[19] This approach allowed her to prioritize subjects aligned with her curiosity, including biology, mathematics, and physics, enabling accelerated progress unhindered by standardized pacing or administrative requirements.^[20] By age eight, Deming had developed a profound interest in the biology of aging, prompting her to independently study foundational concepts in the field through available resources.^[21] She taught herself biology during this homeschooling period, mastering key principles that informed her later focus on longevity mechanisms, such as cellular processes and genetic factors influencing lifespan.^[19] This self-education contrasted with traditional systems by emphasizing depth in targeted topics over broad, rote coverage, which Deming later attributed to cultivating unconventional problem-solving skills.^[20] The absence of institutional constraints in homeschooling facilitated Deming's ability to concentrate on causal questions in aging biology, such as why organisms deteriorate over time, fostering a rigorous, inquiry-driven mindset that prioritized empirical exploration over prescribed methodologies.^[20] By her early teens, this training had built foundational competencies in experimental reasoning and biological literacy, setting the stage for advanced application while avoiding the diluted focus often imposed by group-based education.^[19]

Laboratory Work at UCSF

At approximately age 12, following her family's relocation from New Zealand, Laura Deming joined Cynthia Kenyon's biogerontology laboratory at the University of California, San Francisco (UCSF), where she conducted hands-on research into aging mechanisms using the nematode Caenorhabditis elegans as a primary model organism.^[2]^[22] Kenyon's lab had established foundational evidence that mutations in the daf-2 gene, encoding a homolog of the insulin/IGF-1 receptor, extend mean lifespan in C. elegans by approximately twofold through diminished signaling in the insulin-like pathway, with effects including delayed reproduction, improved stress resistance, and reversal of age-associated declines in pharyngeal pumping and mobility.^[11] Deming's contributions focused on extending these genetic interventions to generate longer-lived strains, assisting in experiments that combined daf-2 reductions with other perturbations to achieve lifespan extensions up to sevenfold relative to wild-type controls.^[11] These efforts included investigations into mimics of dietary restriction, such as genetic alterations affecting TOR signaling or eat-2 mutations that reduce feeding and caloric intake, which synergized with insulin pathway modulation to produce robust, heritable lifespan prolongations verifiable through survival curve assays tracking thousands of synchronized worms under controlled temperatures (typically 20°C).^[23] Direct causal links were established via RNAi knockdowns or pharmacological interventions that phenocopied mutation effects, demonstrating reversibility of aging biomarkers like germline atrophy and proteotoxic stress accumulation, independent of developmental delays.^[11] While C. elegans findings do not guarantee equivalent outcomes in mammals, the core insulin/IGF-1 pathway implicated shows partial conservation, as evidenced by analogous lifespan extensions in insulin receptor knockout mice (up to 30% increase) and dwarfism models with reduced IGF-1, supporting pathway-level mechanistic insights without implying universal scalability to humans.^[11] Model limitations persist, including C. elegans' short baseline lifespan (2-3 weeks) and lack of complex tissues like a vascular system, necessitating cautious extrapolation despite replicated genetic homologies.^[23]

Thiel Fellowship and MIT Experience

In 2009, at age 14, Deming enrolled at the Massachusetts Institute of Technology (MIT) to study biology, completing her sophomore year amid coursework in systems biology and regenerative medicine.^[5] By 2011, at age 17, she was selected as one of the inaugural Thiel Fellows, receiving $100,000 from the Thiel Foundation to forgo traditional higher education for two years and pursue independent projects.^[24] ^[25] This required her to withdraw from MIT, forgoing further academic credentials in favor of direct application of her interests in aging research.^[26] Deming utilized the fellowship to fund personal investigations into aging biomarkers, allowing her to operate independently of academia's grant cycles and institutional constraints, which often prioritize incremental publications over high-risk innovation.^[16] The decision underscored the opportunity costs of prolonged university training, as evidenced by Thiel's critique of credentialism as a barrier to breakthroughs, where time spent in lectures delays real-world experimentation.^[27] Empirical data on Thiel Fellows supports this path's viability: over a decade, the program has generated over $750 billion in company value with a 13.79% unicorn formation rate among participants, outperforming typical elite university entrepreneurship benchmarks that emphasize degrees before action.^[28] This fellowship period marked Deming's pivot from structured lab and classroom environments to entrepreneurial autonomy, accelerating her trajectory beyond the slower pace of academic progression, where PhD timelines can exceed five years with uncertain funding.^[29] Fellows like Deming demonstrate that skipping formal credentials enables faster iteration on scientific ventures, contrasting with traditional graduates who often face delayed market entry due to debt and credential requirements.^[30]

Venture Capital Career

Founding and Growth of the Longevity Fund

Laura Deming founded the Longevity Fund in 2011 at age 17, shortly after receiving the Thiel Fellowship, which provided $100,000 to forgo traditional college and pursue her venture in longevity research full-time.^[3]^[2] The fund emerged as the first venture capital entity dedicated exclusively to investing in companies targeting aging biology, driven by the recognition that aging underlies the majority of chronic diseases responsible for over 70% of deaths globally.^[11]^[31] Its core thesis emphasized addressing aging as a causal root rather than merely treating downstream symptoms, focusing on high-risk, high-reward interventions like causal therapies to extend healthy lifespan, in response to the historical underfunding of aging research by traditional biomedical investors.^[32] The fund began modestly with Longevity Fund I, targeting 5-10 seed-stage investments of $100,000 to $1 million each in U.S.-based companies advancing longevity technologies.^[33] It grew through subsequent vintages, raising $27 million by 2018 for expanded commitments, followed by a second fund of $144 million that demonstrated scaling capacity.^[11] By the early 2020s, the firm had launched a third fund, reflecting assets under management exceeding $100 million cumulatively and attracting limited partners through a proven track record of derisking biology via early-stage bets that advanced portfolio companies toward clinical trials and regulatory milestones.^[34] Strategic evolution included a post-2020 emphasis on empirical validation, measured by portfolio outcomes such as drug candidates entering human trials and follow-on funding exceeding $1 billion across investments, which bolstered LP confidence in the fund's ability to navigate high-risk longevity biology.^[35] Adaptations incorporated emerging tools like AI for drug discovery in select deals, aligning with broader shifts in biotech to accelerate target identification and validation amid persistent underinvestment in causal aging interventions.^[36] This market-driven approach positioned the Longevity Fund as an institutional builder, evolving from bootstrapped origins to a multi-fund platform sustaining growth in a niche historically sidelined by symptom-focused healthcare paradigms.^[32]

Key Investments and Portfolio Outcomes

The Longevity Fund's portfolio has yielded three initial public offerings (IPOs) and one acquisition, including Decibel Therapeutics (focused on regenerative therapies for age-related hearing loss), Precision BioSciences (gene editing technologies applicable to degenerative conditions), and ALX Oncology (immunotherapies targeting cancer, a hallmark of aging).^[37] ^[38] These exits demonstrate financial returns in early-stage biotech investments aligned with the fund's thesis of addressing aging through disease-specific interventions, though specific return multiples remain undisclosed.^[32] Among targeted longevity bets, the fund's investment in Rubedo Life Sciences supported development of senolytic therapies to clear pathologic senescent cells. In May 2025, Rubedo dosed the first patient in a Phase 1 trial of its lead candidate RLS-1496, a topical GPX4 modulator for actinic keratosis, with plans for Phase 1b/2a expansion following FDA IND clearance.^[39] ^[40] This progression validates causal targeting of senescence in human trials, despite prior preclinical challenges in selectivity. Similarly, Gordian Biotechnology, invested for its genetic resilience screening, raised $60 million in April 2024 to deploy an in vivo platform predicting therapeutic outcomes for complex age-related diseases like neurodegeneration, though no candidates have entered clinical stages as of late 2025.^[41] ^[42] Biotech's inherent 90%+ attrition rate from preclinical to approval underscores the high-risk profile, with trial failures common even in advanced pipelines; however, these outcomes—IPOs providing liquidity and candidates reaching Phase 1—offer empirical learnings on repair mechanisms, countering critiques of unfalsifiable speculation by grounding investments in testable human data.^[32] No portfolio-wide return metrics are public, but aggregate follow-on funding exceeding $500 million by 2018 signals validated theses amid sector-wide volatility.^[43]

Expansion into Other Initiatives

In 2023, Deming co-founded age1, a venture capital firm dedicated to early-stage investments in longevity-focused biotechnology, raising $35 million to fund ambitious projects aimed at extending human healthspan.^[1] As venture partner, she has directed capital toward companies developing interventions for aging-related decline, including Loyal, a startup engineering drugs to prolong canine lifespans as a model for human applications.^[6] Loyal's LOY-002, targeting senior large-breed dogs, received FDA concurrence in November 2023 that preclinical data demonstrated a reasonable expectation of effectiveness for lifespan extension, enabling progression to pivotal trials.^[44] By early 2025, Loyal reported advancements in this pipeline, highlighting regulatory pathways for aging-targeted therapies in veterinary medicine.^[45] Complementing her investment activities, Deming launched Cradle in 2024 as co-founder and CEO, a company engineering reversible cryopreservation to induce medical hibernation in terminal patients, suspending biological aging until curative therapies emerge.^[46] Cradle's approach leverages advances in cooling and stabilization techniques to preserve whole-body viability, positioning it as a bridge technology for acute life-extension scenarios beyond chronic disease management.^[3] These efforts represent a strategic broadening from traditional fund management to operational leadership and targeted species-specific trials, while anchoring in longevity biology; age1's portfolio emphasizes foundational tools like genomic analytics from firms such as Fauna Bio, whereas Cradle pursues direct biophysical interventions.^[47] In 2025, Deming highlighted these initiatives in public forums, including a panel at the Milken Institute Global Conference on May 6, discussing scalable cryopreservation's role in clinical pipelines, and interviews underscoring empirical validation through animal models before human translation.^[3]^[48]

Views on Aging and Longevity

Core Scientific Theses

Laura Deming conceptualizes aging as the progressive accumulation of molecular and cellular damage across multiple biological systems, rather than an inevitable or fully programmed process, with the potential for reversal through targeted interventions that address these underlying failures. This view emphasizes damage types such as epigenetic drift, where cumulative alterations in gene expression patterns disrupt cellular identity and function over time, and loss of proteostasis, characterized by impaired protein folding, aggregation, and degradation due to declining lysosomal efficiency. Additional contributors include the buildup of senescent cells, which cease division and secrete inflammatory factors exacerbating tissue dysfunction.^[17]^[4] To counteract these damages, Deming advocates for mechanistic interventions like partial cellular reprogramming, employing subsets of Yamanaka factors—transcription factors (Oct4, Sox2, Klf4, and optionally c-Myc) originally identified in 2006—to transiently reset epigenetic states without full dedifferentiation to pluripotency, thereby restoring youthful cellular function. Advances in the 2010s, including cyclic expression protocols, have demonstrated feasibility in preclinical models by mitigating age-related epigenetic noise and improving tissue repair. Other approaches target specific damages, such as senolytics to eliminate senescent cells or enhancers of autophagy to bolster proteostasis.^[17]^[49]^[4] Empirical support derives primarily from invertebrate and rodent models, where interventions yield quantifiable extensions in healthspan and lifespan, though Deming stresses cautious extrapolation to humans given interspecies physiological differences. In C. elegans worms, genetic perturbations in insulin/IGF signaling pathways double lifespan, with analogous effects observed in mice via dietary or pharmacological mimics. Mouse studies show senescent cell clearance extending median lifespan to approximately 135% of controls in certain contexts, while caloric restriction (reducing intake by 40%) or drugs like rapamycin (extending lifespan 10-27%) and metformin (6% extension) demonstrate damage reversal proofs-of-concept. Human analogs, such as metformin trials, provide early translational evidence but require further validation for longevity endpoints.^[17]^[50]^[4]^[51]

Treatment of Aging as a Treatable Condition

Deming posits that regulatory recognition of aging as a modifiable condition, rather than an inevitable process, would facilitate approvals using direct endpoints such as lifespan extension or validated biomarkers of biological age, bypassing the limitations of disease-specific trials that fragment research efforts.^[4] This approach contrasts with prevailing siloed funding models, where resources target disparate age-related diseases like Alzheimer's or cardiovascular conditions without addressing underlying causal drivers such as genomic instability or cellular senescence, leading to inefficiencies in resource allocation and therapeutic development.^[17] Empirical evidence from model organisms, including worms and mice, demonstrates that interventions modulating these hallmarks—such as caloric restriction mimetics or senolytics—can extend healthspan by 20-30% through causal mechanisms like reduced inflammation and improved proteostasis, supporting the rationale for unified aging-focused trials over symptom palliation.^[52] A key milestone in this advocacy occurred in November 2023, when the FDA accepted an investigational new drug application from Loyal, a Longevity Fund-backed company, for LOY-001, a therapy aimed at extending lifespan in large-breed dogs by targeting insulin-like growth factor 1 signaling, a pathway linked to accelerated aging.^[53]^[54] This precedent establishes feasibility for age-related endpoints in veterinary contexts, potentially informing human applications by validating surrogate measures like epigenetic clocks, and highlights how such approvals could catalyze market entry for interventions addressing root causes across species.^[4] Deming's fund has supported analogous human-oriented efforts, including investments in companies developing therapies against senescence and mitochondrial dysfunction, which preclinical data indicate delay multiple comorbidities by intervening at causal levels rather than downstream symptoms.^[32] While this paradigm promises efficiency gains—evidenced by conserved aging pathways across taxa—risks include translational failures, as seen in historical discrepancies between rodent models and human outcomes for compounds like rapamycin analogs, where efficacy wanes due to physiological differences.00258-1/fulltext) Nonetheless, causal realism favors proactive intervention: observational data from human centenarians and longitudinal cohorts reveal modifiable factors like telomere attrition amenable to therapy, outweighing inaction amid rising age-related disease burdens projected to affect 2 billion people by 2050.^[55] Deming emphasizes that regulatory evolution, informed by such precedents, could mitigate hype by prioritizing rigorous, mechanism-based validation over anecdotal claims.^[4]

Societal and Economic Implications

Deming emphasizes that extending healthspan would amplify economic productivity by enabling prolonged periods of high-functioning work and innovation, countering physical limitations that currently curtail contributions from older individuals. For instance, she envisions scenarios where people pursue second careers or advanced degrees, such as a PhD at age 50, thereby sustaining creative output akin to historical examples like artist Hokusai's late-life masterpieces.^[4]^[48] Empirical analyses support this, showing that a one-year increase in life expectancy associates with roughly a 4% rise in GDP per capita through enhanced labor productivity and reduced disease burdens.^[56] Such extensions would also restore individual agency over life trajectories, allowing choices about physical capabilities at advanced ages—such as running with grandchildren at 80—rather than accepting deterministic decline as inevitable.^[4] This shift challenges entrenched biases toward age-related frailty, potentially leveling opportunities across life stages and fostering broader societal dynamism.^[4] Deming recognizes critiques regarding wealth concentration, noting that early adopters with capital could compound advantages, exacerbating inequalities akin to being "born way earlier."^[48] However, she implies mitigation through adaptive innovation, where therapeutic costs decline exponentially—mirroring computing's Moore's Law trajectory—and historical precedents demonstrate that breakthroughs, from vaccines to antibiotics, eventually permeate populations despite initial disparities.^[48] In discussions from 2024 and 2025, Deming views social challenges, such as revising retirement norms amid longer productive spans, as resolvable via cultural and behavioral adaptation rather than halting progress; extended timelines may even incentivize prosocial cooperation, as game-theoretic models suggest repeated interactions favor collaboration over short-term exploitation.^[4]^[48]

Impact, Reception, and Criticisms

Achievements in Funding Innovation

Through the Longevity Fund, which Deming founded in 2011 as the first venture capital firm dedicated to longevity biotechnology, several portfolio companies achieved significant milestones, including three initial public offerings (IPOs) and one acquisition, such as Decibel Therapeutics, Precision BioSciences, and ALX Oncology Holdings.^[37] These exits demonstrated early proof of financial viability in the sector, with the fund supporting advancements like drug candidates entering patients for age-related diseases.^[32] In 2023, the fund facilitated an exit for portfolio company Herophilus via acquisition, further evidencing returns from longevity-focused investments.^[57] Deming's efforts contributed to a broader surge in longevity sector funding, with global investments totaling $8.5 billion across 331 deals in 2024, more than doubling from 2023 levels and reflecting increased venture capital allocation to anti-aging therapeutics.^[58] This growth aligned with projections for the longevity biotech market reaching $72.6 billion, driven by investor recognition of scalable opportunities in age-related interventions.^[59] By prioritizing early-stage bets on biological reprogramming and senescent cell clearance, the fund helped shift traditional biotech venture models toward direct aging targets, evidenced by subsequent funds like age1 deploying over $100 million in 2022-2023 for similar moonshot pursuits.^[7] Her recognition as one of the youngest Thiel Fellowship recipients in 2011, receiving $100,000 to establish the Longevity Fund, underscored her role in pioneering institutionally backed longevity innovation.^[35] These outcomes validated targeted funding strategies, with portfolio progress into clinical stages for age-related indications by the early 2020s, positioning Deming's approach as a catalyst for empirical advancements over speculative hype.^[60]

Scientific and Ethical Debates

Critics of longevity research, including Deming's investments, highlight persistent challenges in translating preclinical findings from model organisms to humans, citing metabolic divergences and the infeasibility of multi-decade trials. For example, while genetic mutations in insulin/IGF signaling pathways extend mouse lifespan by 20-50% in some strains, fewer than 20% of mouse models respond consistently to interventions like caloric restriction, raising doubts about broad human applicability.^[17] Deming responds that evolutionary conservation of aging mechanisms across species—evidenced by over 95 validated lifespan-extending interventions in mice—supports incremental progress, particularly through biomarkers like epigenetic clocks and senescent cell accumulation, which enable measurable reversal of biological age without awaiting full lifespan outcomes.^[4]^[17] Ethical concerns center on potential exacerbation of socioeconomic disparities, with detractors arguing that early-stage therapies, such as senolytics or metformin repurposing, would initially benefit only high-net-worth individuals, entrenching a "health elite" amid existing life expectancy gaps of up to 15 years between rich and poor cohorts.^[61] Proponents, including Deming, counter that historical patterns in biotechnology—such as insulin's price drop from $1,500 per year in the 1920s (adjusted) to under $300 today—demonstrate how scaled production and competition democratize access, ultimately broadening societal health gains.^[4] Claims of overpopulation from extended lifespans are rebutted by empirical demographic shifts, including global fertility rates falling below replacement levels (2.3 in 2023 per UN data), which suggest healthier longevity could stabilize rather than strain populations. Regulatory barriers amplify these debates, as the FDA classifies aging as a natural process rather than a disease, mandating trials target specific pathologies like frailty or neurodegeneration, which extend timelines and costs—often decades for endpoints like mortality.^[62] Deming views such frameworks as outdated social hurdles, advocating validation of aging biomarkers (e.g., via composite indices of inflammation and telomere length) as surrogate endpoints to accelerate approvals, and points to precedents like forthcoming canine anti-aging drugs as catalysts for human policy evolution.^[4]^[63]

Responses to Skepticism and Regulatory Challenges

Deming has addressed skepticism about the viability of longevity interventions by framing the core obstacles as regulatory and societal rather than fundamental scientific impossibilities, pointing to accumulating evidence from model organisms and early human trials that demonstrate targeted modulation of aging pathways can extend healthspan. In a March 2024 discussion, she highlighted a recent regulatory breakthrough for canine therapies as a key indicator of progress, arguing that such approvals validate the approach of treating aging-related decline as addressable through incremental, data-driven advancements rather than requiring complete reversal of biological clocks.^[4] Regulatory challenges in human longevity applications persist due to conservative frameworks prioritizing disease-specific endpoints over holistic healthspan metrics, yet the field has secured partial victories in veterinary contexts that serve as proofs-of-concept. For instance, in 2024, the U.S. FDA granted acceptance of reasonable expectation of effectiveness (RXE) for LOY-001, a drug from Loyal targeting IGF-1 signaling to extend lifespan in large-breed dogs over 7 years old, followed by similar nods for LOY-002 in February 2025 for senior dogs of various sizes, focusing on metabolic dysfunction.^[64]^[65] These developments underscore R&D efficiency gains, with streamlined veterinary pathways enabling faster iteration—Loyal's programs advanced from preclinical IGF-1 inhibition data showing delayed age-related pathologies to RXE status within years, bypassing full pivotal trials initially.^[66] To counter funding winters and public doubt, which have historically stemmed from perceptions of longevity as speculative amid biotech volatility, Deming and field proponents emphasize pilot data from interventions like low-dose rapamycin in companion dogs, where a 2025 NIH-rescued study with $7 million funding hypothesizes weekly dosing could extend mature canine lifespans by addressing immunosenescence and frailty.^[67] Economic modeling further bolsters resilience arguments, projecting that even modest delays in age-related diseases could yield trillions in societal savings through reduced healthcare burdens, as evidenced by analyses of compressed morbidity scenarios where interventions shift disease onset later in life.^[68] Looking ahead to 2025, Deming anticipates AI acceleration in target identification and trial design to mitigate remaining risks, enabling rapid hypothesis testing that addresses skeptics' concerns over efficacy timelines by compressing discovery cycles from years to months, as seen in emerging on-chain AI agents for longevity datasets.^[69]

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Laura Deming is partner and founder of The Longevity Fund and a venture capitalist and scientist dedicated to curing age-related diseases.
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The Longevity Fund is a venture capital firm founded in 2011. It is primarily based out of San Francisco, United States. As of Jan 2022, The Longevity Fund ...
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Financial Details - The Longevity Fund - Crunchbase
The Longevity Fund 's most notable exits include Decibel Therapeutics , Precision BioSciences , and ALX Oncology . Lead Investments 1. Investments 21.
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Rubedo Life Sciences Announces First Patient Dosed with Lead ...
... Phase 1 Clinical Trial. First patient dosed with topical RLS-1496 in clinical trial will assess the safety and clinical effects of single and multiple doses ...
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U.S. FDA Clears IND for Rubedo's RLS-1496 for AK; Dr. Emma ...
The FDA has cleared the IND application for a Phase 1b/2a study of Rubedo Life Sciences' RLS-1496 in patients with actinic keratosis (AK).
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Gordian launches with $60m and platform that predicts outcomes in ...
Apr 26, 2024 · The company says it has raised $60 million to date from investors including The Longevity Fund, Arctica Ventures, Athos Service GmbH, Gigafund, ...
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Gordian Biotechnology Introduces High-Throughput In Vivo ...
Gordian Biotechnology Introduces High-Throughput In Vivo Screening Platform to Discover Therapies and Better Predict Human Outcomes for Age-Related Diseases. April 26, 2024 • Gordian ... Laura Deming, a partner at The Longevity Fund and Gordian investor.Missing: investment | Show results with:investment
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Longevity Fund Laura Deming on Investing in Aging - Business Insider
Oct 11, 2018 · Deming's Longevity Fund manages $37 million, and to date the investments she's made have since gone on to raise a combined $500 million. One of ...Missing: achievements | Show results with:achievements
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FDA Center for Veterinary Medicine agrees Loyal's data supports ...
Nov 28, 2023 · Loyal was only a few months old and about five people when we decided to begin by targeting the abnormally short lifespan of large breed dogs ...
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Laura ⛰️ on X
Feb 26, 2025 · Laura ⛰️ · @LauraDeming. GO LOYAL!!!!!!!!!! the ramifications of ... Loyal's drug for senior dog lifespan extension drug LOY-002 has ...Missing: Deming | Show results with:Deming
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Startup Brings New Hope to the Pursuit of Reviving Frozen Bodies
Jun 3, 2024 · Today, in addition to running Cradle, Deming is co-founder and partner at Age1, a new longevity-focused investment firm. She's convinced that ...
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age1 - Emerging Manager Monthly
... age1 cofounder Laura Deming at the age of 16. Portfolio includes Loyal, Gordian Bio, Arda Tx, Fauna Bio, etc. 2443 Fillmore St, #380-4690, San Francisco, CA ...<|separator|>
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Laura Deming — On Pausing Biological Time & Preserving the ...
May 21, 2025 · At 17, she founded The Longevity Fund (followed by age1), the first VC firm dedicated to longevity biotech, after being selected in the initial ...Missing: achievements | Show results with:achievements
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203268/
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Longevity biotechnology: bridging AI, biomarkers, geroscience and ...
We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and ...
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About us - Loyal
Celine Halioua · Founder & CEO ; Kevin Zhang · Partner, Bain Capital Ventures ; Laura Deming · Founder/GP, Longevity Fund ; Blake Scholl · Founder/CEO, Boom Supersonic.
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Extending healthspans by targeting the hallmarks of aging - Nature
Studies suggest that targeting the underlying causes of aging with drugs before symptoms manifest may be a promising strategy for mitigating chronic diseases ...
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Effects of Health Factors on GDP Growth: Empirical Evidence ... - MDPI
Similarly, Bloom et al. [14] reported that a one-year increase in population life expectancy leads to a 4% increase in productivity. However, there are some ...
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The Longevity Fund investment portfolio | PitchBook
The firm seeks to invest in seed and series A stage companies operating in the life sciences, digital health, oncology, and impact investing sectors. Business ...
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Longevity Investment More Than Doubled to $8.5bn in 2024
May 16, 2025 · Technology today published the 2024 Annual Longevity Investment Report – a full-year report on the state of investment in the longevity sector – ...Missing: size growth
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Longevity Biotech Surges As $72.6B Market Forecast Sparks ...
Oct 16, 2025 · This new model enables Avant and its partners to leverage complementary expertise and resources while mitigating traditional development costs ...
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The Longevity Fund - Venture Capital Archive
Aug 22, 2025 · The Longevity Fund, founded by Laura Deming in 2011, focuses on investing in biotechnology and health tech companies that aim to develop ...
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Medicine, ageing and human longevity: The economics and ethics ...
Jul 1, 2005 · In these societies, existing health inequalities will be exacerbated if social healthcare systems deny citizens access to effective anti‐ageing ...Missing: elitism | Show results with:elitism
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Information on FDA review of geroscience-related IND applications
Oct 22, 2024 · Aging mechanisms that operate over the lifespan may produce their clinical effects only after decades. Hence, a very long duration may be ...Missing: Deming | Show results with:Deming
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[PDF] Roadmap to 2030 for New Drug Evaluation in Older Adults - FDA
Mar 23, 2021 · FDA is responsible for advancing the public health by helping to speed innovations that make medical products more.Missing: Deming | Show results with:Deming<|control11|><|separator|>
[64]
Not just for big dogs! Our senior dog program receives preliminary ...
Feb 26, 2025 · LOY-002, our program bringing longevity to dogs of almost all sizes, has also earned its formal FDA acceptance for reasonable expectation of efficacy (RXE).
[65]
Second drug for canine healthy lifespan extension receives FDA ...
Feb 26, 2025 · The drug, LOY-002, targets age-related metabolic dysfunction and is also designed to improved quality of life in canines aged 10 years and older ...
[66]
Loyal Receives FDA Acceptance of RXE for Senior Dog Lifespan ...
Feb 27, 2025 · The drug aims to extend the lifespan of senior dogs and maintain their quality of life as they age, building on the company's previous RXE acceptance.<|separator|>
[67]
$$7M grant rescues dog study investigating rapamycin for canine aging
Feb 26, 2025 · The researchers hypothesized that a once-weekly, weight-adjusted low dose of rapamycin will extend the lifespan of mature or senior dogs—the ...
[68]
Longevity progress is real. So are the scams. - Freethink
Oct 1, 2025 · Over the last few decades, longevity research has made serious progress. ... longevity treatments in humans, should someone be willing to fund ...
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Blog - VitaDAO
Sep 12, 2025 · ... daf-2 insulin/IGF-1 receptor mutant. Disrupting the mitochondrial ... 80,000 Hours Podcast - Laura Deming on the science that could keep us ...