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Middle rectal artery

The middle rectal artery is a small visceral branch of the anterior division of the internal iliac artery that provides arterial supply to the middle and lower portions of the rectum, as well as adjacent structures such as the prostate, seminal vesicles, and vagina in some cases.^[1] It typically arises bilaterally from the internal iliac artery and courses inferomedially just above the pelvic floor, often intermingling with fibers of the inferior hypogastric plexus within the lateral rectal ligaments before penetrating the mesorectal fascia to anastomose with the superior and inferior rectal arteries.^[2] Anatomical variations of the middle rectal artery are common and clinically significant, with studies reporting its presence in approximately 62.5% of pelvic sides, more frequently in males (75%) and on the right side (70%), and often unilaterally or bilaterally absent.^[3] When present, it frequently originates not directly from the internal iliac artery but from associated vessels such as the internal pudendal artery (44% of cases), inferior gluteal artery (24%), or others including the gluteal-pudendal trunk, inferior vesical artery, or obturator artery.^[3] These variations influence surgical approaches, particularly in total mesorectal excision for rectal cancer, where identification of the artery helps minimize vascular and nerve injury during dissection of the lateral ligaments.^[3] Additionally, its role in forming weak anastomoses contributes to collateral circulation but can complicate interventions like embolization for rectal hemorrhage.^[1]

Anatomy

Origin

The middle rectal artery arises from the anterior division of the internal iliac artery or its associated branches, such as the internal pudendal or inferior gluteal arteries, within the lesser pelvis.^[4]^[3] This origin occurs at the level of the pelvic cavity, where the internal iliac artery bifurcates into anterior and posterior divisions to supply the pelvic viscera.^[5] The artery emerges as a small branch, and it may share a common trunk with the inferior vesical artery in males, before directing its course toward the rectum.^[4] Upon emergence, the proximal segment of the middle rectal artery exhibits an average external diameter of approximately 1.7 mm and extends for an average total length of about 7 cm before penetrating the rectal wall.^[6] This initial portion travels inferiorly through the pelvic fascia, ensheathed by branches of the inferior hypogastric plexus, providing a direct vascular link from the parent vessel to the rectal mesentery.^[1] Embryologically, the middle rectal artery develops as a component of the anterior division of the internal iliac artery, which itself arises from the proximal portion of the embryonic umbilical artery during the first trimester of fetal development.^[4] The umbilical artery serves as the primary conduit for fetal circulation to the placenta, and its cranial segments persist postnatally to form the internal iliac and its visceral branches, including the middle rectal artery, adapting to supply the pelvic structures after birth.^[7]

Course and relations

The middle rectal artery arises from the anterior division of the internal iliac artery and descends inferiorly across the pelvic floor within the lesser pelvis.^[1]^[8] It initially follows a vertical trajectory before turning approximately 90 degrees to run transversely toward the posterolateral aspect of the lower rectum, entering the mesorectum laterally.^[1]^[9] This pathway positions the artery in close proximity to the pelvic diaphragm, including the levator ani muscle inferiorly and the fascia of the obturator internus muscle posterolaterally.^[10] Throughout its course, the middle rectal artery pierces the endopelvic fascia and becomes ensheathed within the mesorectal fat, accompanied by branches of the inferior hypogastric plexus.^[11] These neural elements contribute to the formation of the lateral rectal ligaments, which represent condensations of fascia extending from the mesorectum to the pelvic sidewall.^[1]^[8] The artery's embedding in these fascial structures underscores its spatial integration with the pelvic autonomic innervation and connective tissues, facilitating its approach to the rectal wall without direct exposure to the peritoneal cavity.^[11]

Branches

The middle rectal artery predominantly gives rise to terminal branches without major named intermediate vessels, dividing directly into smaller arteries that penetrate the rectal wall. These terminal branches typically number 1-3, with diameters ranging from 0.5 to 3.5 mm, and enter the mesorectum from ventrolateral, lateral, or dorsolateral aspects before supplying the muscularis layer of the middle and lower rectum.^[12] As the artery courses through the lateral rectal ligaments, it maintains this pattern of subdivision to reach its target.^[1] In males, accessory branches may arise from the middle rectal artery to supply adjacent structures, including prostatic branches to the prostate and seminal branches to the seminal vesicles.^[1]^[8] These prostatic branches, when present, can contribute to the vascular supply of the prostate, though they are less common than those originating from the inferior vesical artery.^[9] In females, the middle rectal artery occasionally produces vaginal branches that extend to the upper vagina.^[1]^[8] Rare additional branches from the middle rectal artery include an inferior lateral sacral artery, which may arise unilaterally or bilaterally in a subset of cases.^[1]

Supply and function

Regions supplied

The middle rectal artery primarily supplies the middle and lower portions of the rectum, delivering oxygenated blood to the muscularis propria and submucosa in these regions above the pectinate line.^[4]^[13] This vascular contribution ensures nourishment to the rectal wall's structural layers, supporting the organ's integrity and function in the distal gastrointestinal tract.^[14] It also provides secondary vascularization to the upper anal canal, extending its reach to the proximal segment of this structure for comprehensive coverage of the anorectal transition zone.^[14] Additionally, the artery supplies portions of the rectal mesentery, including the mesorectal fat and connective tissues surrounding the rectum, as well as adjacent pelvic floor tissues encountered along its course.^[2] Through its branches, the middle rectal artery participates in forming the rectal arterial arcade, which enables circumferential distribution of blood to these end-target tissues.^[9]

Anastomoses

The middle rectal artery forms important anastomoses with the superior rectal artery, a branch of the inferior mesenteric artery, contributing to the formation of the upper rectal arterial arcade that ensures collateral circulation along the proximal and middle rectum.^[15] These interconnections provide redundancy in blood supply, allowing collateral flow from the inferior mesenteric artery to support the middle rectal territory when needed.^[16] Additionally, the middle rectal artery connects with the inferior rectal artery, derived from the internal pudendal artery, particularly at the level of the lower rectum and anal canal, facilitating a continuous vascular network from the pelvic sidewall to the distal anorectal region.^[17] It also establishes links with the inferior vesical artery, enhancing pelvic collateral pathways that integrate rectal and bladder vascularization.^[18] Further connections occur with the median sacral artery, a branch of the abdominal aorta, supporting overall pelvic collateral flow and potential contributions to rectal perfusion in the posterior midline.^[19] Although these anastomoses are often described as relatively weak compared to those in the gastrointestinal tract, they play a crucial role in preventing ischemia during rectal pathologies or surgical interventions by maintaining alternative routes for blood delivery to the rectal wall.^[20] This collateral network is particularly significant in scenarios involving compromised primary supply, underscoring its importance in preserving tissue viability.^[21]

Anatomical variations

Prevalence

The prevalence of the middle rectal artery exhibits significant variability across anatomical studies, with historical reviews documenting rates ranging from 12% to 97% depending on the methodology and population examined.^[22] A systematic review and meta-analysis of 28 studies involving 880 patients and 1905 pelvic sides reported an overall pooled prevalence of 59.8% in individuals and 55.2% of pelvic sides.^[23] Studies indicate a higher incidence in males compared to females, with the artery more often absent in women; for example, cadaveric studies report presence in approximately 75% of male pelvic sides versus 50% in females.^[9]^[24] It is also more frequently present on the right side (70%) than the left (55%).^[24] For instance, angiographic evaluations in male patients have shown presence in approximately 36% of cases.^[16] Historical reviews report bilateral presence in approximately 37% of cases and unilateral in 20%, though patterns vary by study, with imaging often detecting lower overall prevalence and potentially more unilateral cases.^[22] Prevalence rates are influenced by study type, with cadaveric dissections yielding higher detection (up to 79.3%) than imaging modalities such as angiography (30-40%), attributable to the artery's small caliber and potential oversight in non-invasive techniques.^[23]^[7]

Types of variations

The middle rectal artery displays notable morphological variations, particularly in its origin, which deviates from the typical branching off the anterior division of the internal iliac artery. Common alternative origins include the internal pudendal artery, representing the most frequent variant, as well as the inferior gluteal artery, often via a shared gluteal-pudendal trunk.^[24] Other origins encompass the inferior vesical artery, typically as a common trunk, the obturator artery, and the prostatic artery in males; in females, it may arise from or be replaced by the uterine artery.^[9] Less common sites involve direct emergence from the main trunk or posterior division of the internal iliac artery.^[25] Variations in the number of middle rectal arteries per side range from a single vessel to duplicates or multiple branches, altering the vascular supply pattern to the rectum.^[24] The artery may also exhibit absence or hypoplasia, either unilaterally or bilaterally, leading to compensatory perfusion from adjacent vessels such as the superior rectal artery or branches of the inferior rectal artery.^[24]^[9] Classification systems for these variations emphasize categorical distinctions by vascular origin and branching morphology. Major types are delineated by the parent artery (e.g., internal iliac proper versus its pudendal or gluteal branches), with subtypes based on the precise branching site, such as direct from the anterior trunk, via an intermediate trunk, or from the posterior trunk; Kim et al. (2022) describe seven major types (I–VII) with corresponding minor subtypes (a–c).^[24] Broader frameworks, such as the modified Adachi classification for internal iliac artery branching, provide context for anterior division variations that may influence middle rectal artery origins and multiplicity.^[25]

Clinical significance

Surgical applications

In total mesorectal excision (TME) for rectal cancer, the middle rectal artery (MRA) is frequently encountered during deep posterolateral dissection and is typically ligated to ensure complete removal of the mesorectum, control bleeding, and maintain the integrity of the mesorectal fascia while preserving the pelvic autonomic plexus.^[26] Ligation is performed using vascular clips or energy devices in minimally invasive approaches, as the MRA is the primary vessel penetrating the proper rectal fascia, potentially compromising TME if not addressed.^[26] This step is crucial for reducing local recurrence rates by facilitating adequate lateral margins, with the MRA present in approximately 71% of cases.^[26] During low anterior resection (LAR) for middle or low rectal tumors, surgical techniques emphasize careful dissection to avoid inadvertent injury to the MRA, ensuring adequate vascular integrity for postoperative recovery.^[27] In prostatectomy and hysterectomy, the MRA poses a risk of injury during pelvic sidewall dissection, potentially leading to significant bleeding and pelvic hematoma formation due to its course through the lateral rectal ligaments.^[28] Accessory branches within these ligaments, present in up to 25% of cases, increase the likelihood of vascular disruption if not identified intraoperatively.^[28] Prompt ligation or hemostasis is required to mitigate hemorrhage, as uncontrolled bleeding from the MRA can complicate recovery and necessitate further intervention.^[29] Anatomical variations in MRA origin and presence—observed in 62.5% of pelvic sides, often arising from the internal pudendal or inferior gluteal arteries—underscore the need for preoperative imaging to map its trajectory for safe dissection in lateral rectal ligaments during rectal or pelvic surgeries.^[24] Contrast-enhanced MRI or CT angiography allows visualization of these variations, enabling tailored approaches to minimize injury risk and optimize outcomes in oncologic resections.^[30] Such imaging is particularly valuable in TME planning, where unexpected MRA encounters could otherwise lead to bleeding or incomplete excision.^[30] Computed tomography (CT) angiography serves as a preoperative tool to delineate the origin, course, and variations of the middle rectal artery through contrast-enhanced imaging of the pelvic vasculature. Retrospective analyses using CT angiography and digital subtraction angiography have identified the artery in approximately 36% of patients.^[16] Contrast enhancement highlights the artery's trajectory toward the rectum, aiding in the assessment of its patency and branching patterns.

Interventional procedures

The middle rectal artery is targeted in hemorrhoidal artery embolization (HAE), a minimally invasive endovascular procedure primarily used to treat symptomatic internal hemorrhoids by reducing arterial blood flow to engorged hemorrhoidal varices.^[31] In HAE, selective embolization of the middle rectal artery, often in conjunction with branches of the superior rectal artery, aims to alleviate bleeding and prolapse without direct surgical intervention on the rectal mucosa.^[32] This artery also plays a role in managing rectal bleeding or arteriovenous malformations (AVMs) through superselective catheterization and embolization, particularly in cases of life-threatening hemorrhage or vascular anomalies where conservative measures fail.^[33] For rectal AVMs, embolization of the middle rectal artery helps control abnormal arteriovenous shunting and prevent recurrent bleeding by occluding feeding vessels.^[34] The procedure typically involves percutaneous access via the femoral artery under fluoroscopic guidance, allowing advancement of a microcatheter to the middle rectal artery origin from the internal iliac artery.^[31] Embolization agents such as polyvinyl alcohol particles, microspheres, or detachable coils are then deployed to achieve proximal occlusion while preserving collateral pathways from adjacent vessels.^[35] This selective approach minimizes nontarget embolization and supports recovery through existing vascular networks. Clinical outcomes demonstrate high technical success rates of 93-100% for middle rectal artery embolization in hemorrhoidal disease, with symptom relief achieved in 80-90% of patients at short-term follow-up.^[36] For rectal bleeding control, embolization yields cessation in over 90% of cases with minimal recurrence.^[33] Complication rates remain low (less than 5%), attributed to robust anastomoses with the superior and inferior rectal arteries that maintain tissue perfusion and avert ischemia.^[32]

Diagnostic imaging

High-resolution pelvic magnetic resonance imaging (MRI), particularly with contrast enhancement, enables visualization of the middle rectal artery within the mesorectum, supporting rectal cancer staging and evaluation of lateral lymph node involvement. In a cohort of 102 patients with lower rectal cancer, contrast-enhanced MRI detected the artery in 65.7% of cases, with bilateral presence observed in 31.4% and unilateral in 34.3%. The artery's visualization, classified as antero-lateral, lateral, or postero-lateral types, was associated with a significantly higher risk of lateral lymph node metastasis (odds ratio 8.922, P=0.045), achieving 95% sensitivity and 97.1% negative predictive value for metastasis prediction.^[37] Integrated diagnostic models combine middle rectal artery visualization with tumor and nodal features to enhance predictive accuracy in rectal cancer staging, particularly for outcomes related to mesorectal and lateral structures. One such model, developed using MRI-detected artery presence alongside lymph node characteristics, predicts lateral lymph node metastasis with high performance (AUC 0.945, sensitivity 96.05%, specificity 81.25%), integrating factors like node short diameter (>10.3 mm threshold) via logistic regression for probability estimation. This approach supports refined assessment of mesorectal fascia involvement by contextualizing vascular anatomy with tumor extension.^[38] The small caliber of the middle rectal artery poses detection challenges, often necessitating advanced sequences such as high-resolution or contrast-enhanced protocols to achieve reliable visualization rates around 65%. Variable prevalence, reported as low as 20-30% in some angiographic studies, further influences detection consistency and requires validation across larger cohorts.^[7] Anatomical variations in origin and course can alter imaging appearance, complicating interpretation without multiplanar reconstruction.^[37]

References

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Middle rectal artery: Anatomy, branches, supply - Kenhub
The middle rectal artery is a branch of the internal iliac artery that supplies the mid and lower portions of the rectum. Master its anatomy now at Kenhub!
[2]
Rectal Artery - an overview | ScienceDirect Topics
The middle rectal arteries arise bilaterally from the corresponding internal iliac artery and run inferomedially just above the pelvic floor to reach the rectum ...
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Anatomy, Abdomen and Pelvis: Internal Iliac Arteries - NCBI - NIH
Jan 17, 2023 · The middle rectal artery travels inferiorly from its origin to supply blood to a large segment of the middle and inferior rectum. It contributes ...
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Morphology of the middle rectal arteries. A study of 30 ... - PubMed
The average external diameter of the middle rectal artery was found to be 1.7 mm, its average length about 7 cm, and the point of penetration in the rectal wall ...
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Angiographic Anatomy of the Male Pelvic Arteries | AJR
In the intrapelvic trajectory, it gives rise to the following branches: superior and inferior vesical arteries, middle rectal artery, prostatic artery, and ...<|control11|><|separator|>
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Middle anorectal artery - e-Anatomy - IMAIOS
The middle rectal artery courses inferiorly across the lesser pelvis, and enters the mesorectum where it is ensheathed by fascia along with the branches of the ...
[9]
Middle rectal artery | Radiology Reference Article - Radiopaedia.org
Apr 18, 2023 · The middle rectal artery supplies the inferior rectum, and anastomoses with the superior and inferior rectal arteries here. Variant anatomy. The ...
[10]
Arteries of the Pelvis - Internal Iliac - Pudendal - TeachMeAnatomy
Middle rectal artery – Travels medially to supply the distal part of the rectum. It also forms anastomoses with the superior rectal artery (derived from the ...
[11]
Exposure of the Middle Rectal Artery and Lateral Ligament of ... - NIH
The middle rectal artery (MRA) and the lateral ligament of the rectum (LLR) have always been controversial surgical landmarks for rectal surgery. Goligher ...
[12]
The Middle Rectal Artery: Revisited Anatomy and Surgical ... - PubMed
Mar 1, 2023 · The middle rectal artery is a relevant anatomical landmark for rectal resection and lateral lymph node dissection, descriptions of this entity are highly ...
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None
### Summary of Arterial Supply to the Rectum (Middle Rectal Artery)
[14]
Anatomy, Abdomen and Pelvis, Rectum - StatPearls - NCBI Bookshelf
This artery supplies the rectum and upper third of the anal canal. The rectum receives additional vascular contributions from the middle rectal artery ...
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middle rectal a. anastomoses with the inferior rectal a and the superior rectal a. middle suprarenal, abdominal aorta, numerous unnamed branches, medial side of ...
[16]
Middle rectal artery: myth or reality? Retrospective study ... - PubMed
This work aimed to study the prevalence and radiologic anatomy of the middle rectal artery (MRA) using computed tomographic angiography (CTA) and digital ...
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Anatomy Tables - Perineum & External Genitalia
inferior rectal a. anastomoses with the middle rectal a. and the superior rectal a. internal pudendal (N404, N405, TG6-28A, TG6-28B, TG6-29A, TG6-29B, TG6 ...
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The median sacral artery in rectal blood supply: A cadaveric study
Apr 22, 2020 · ... median sacral artery (MSA) is not generally considered t ... middle rectal artery, leaving only the IRA, which authors describe ...3 Results · 3.2 Radiography · 4 Discussion
[20]
[PDF] Arterial vascularization of the colon; a guide to surgical resection
Apr 25, 2024 · In such instances, the blood supply to the superior rectum is maintained by the middle rectal artery, whereas the transverse colon receives ...
[21]
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The middle anorectal artery (MAA) is considered to supply the middle and lower parts of the rectum, however, its prevalence and point of origin vary across ...
[22]
Anatomy of the middle rectal artery: a review of the historical literature
Follow-up was conducted via clinical examination and rectoscopy at 1, 3, and 6 months. ... The middle rectal artery is a branch of the internal iliac artery, ...
[23]
The middle anorectal artery: A systematic review and meta‐analysis ...
Apr 27, 2022 · The overall pooled prevalence estimate for the MAA was 59.8% of the patients, and 55.2% of the pelvic sides studied. The vessel was identified ...
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Anatomical Classification of Middle Rectal Arteries
(A) Middle rectal artery arises from the anterior trunk of internal iliac artery, and presents independent course from internal pudendal artery and inferior ...
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Clinical importance of variability in the branching pattern of the ...
The visceral branches of the anterior division are: the superior vesical artery (SVA), inferior vesical artery (IVA), middle rectal artery ... 1–3. 1 ...Retraining Review · 3. Discussion · 3.3. Classifications Of...
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Aug 30, 2024 · For middle and low rectal cancers, however, complete excision of the mesorectum is necessary. This tailored approach is widely accepted and ...
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Interpreting Angiographic Anatomy for Restorative Rectal... - Lippincott
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a review with particular relevance to the hazards of rectal mobilisation
The lateral ligaments may contain an accessory middle rectal artery in 25% of cases. 3. The pelvic autonomic nerves are buried in endopelvic fascia on the ...
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Three patients with life-threatening rectal bleeding are presented, which was controlled by superselective embolization of the middle hemorrhoidal artery.
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