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Pyrogallol

Pyrogallol, also known as 1,2,3-trihydroxybenzene or pyrogallic acid, is an organic compound with the molecular formula C₆H₆O₃ and a molecular weight of 126.11 g/mol. It is a benzenetriol featuring three hydroxyl groups attached to adjacent carbon atoms on a benzene ring, appearing as an odorless white to gray solid that melts at 131–134 °C and boils at 309 °C. Highly soluble in water (507 mg/mL at 25 °C), ethanol, and diethyl ether, pyrogallol serves as a potent reducing agent due to its ability to undergo oxidation and deprotonation in alkaline solutions.^[1]^[2] Historically introduced as one of the earliest photographic developers in the mid-19th century, pyrogallol reduces silver halides to metallic silver in black-and-white film processing, producing fine grain and high contrast images while also acting as a tanning agent for emulsions. Beyond photography, it finds applications as an antioxidant in oils and drug formulations to prevent oxidative damage, a reagent in analytical chemistry for oxygen absorption and metal complexation, and in the dyeing of hair, leather, and suturing materials due to its polyphenolic structure. Pyrogallol occurs naturally as a plant metabolite in tannins, anthocyanins, and other compounds, contributing to its biological roles as a phenolic donor.^[1]^[2] Despite its utility, pyrogallol exhibits significant toxicity, with an oral LD50 of 300 mg/kg in mice, causing irritation to skin, eyes, and respiratory tract upon exposure; it is also a potential skin sensitizer and has shown equivocal carcinogenic evidence in animal studies. Its handling requires precautions, including protective equipment, due to risks of acute toxicity via ingestion, inhalation, or dermal contact, and it is classified as harmful to aquatic life with long-lasting effects.^[1]^[2]

Properties

Physical properties

Pyrogallol has the molecular formula C₆H₆O₃ and a molecular weight of 126.11 g/mol.^[1] It appears as a white to slightly yellow crystalline powder or solid that darkens upon exposure to air and light.^[3] The compound has a melting point of 131–134 °C and a boiling point of 309 °C, at which it decomposes.^[4] Pyrogallol exhibits high solubility in water, 507 g/L at 25 °C, and is very soluble in ethanol and diethyl ether, while being slightly soluble in benzene and chloroform.^[1] Its density is 1.45 g/cm³ at 20 °C.^[3] The vapor pressure is low, at 4.79 × 10⁻⁴ mmHg at 25 °C.^[1]

Chemical properties

Pyrogallol, chemically known as benzene-1,2,3-triol, is a benzenetriol with the molecular formula C₆H₆O₃, featuring three hydroxyl groups attached to adjacent carbon atoms (positions 1, 2, and 3) on a benzene ring.^[1]^[5] This structure is also referred to by synonyms such as 1,2,3-trihydroxybenzene and pyrogallic acid.^[6] The ortho arrangement of the three hydroxyl groups facilitates intramolecular hydrogen bonding, forming five- or six-membered rings that stabilize the molecule and influence its tautomerism, predominantly favoring the enol form over keto tautomers.^[7] This configuration enhances the acidity of the phenolic protons, with reported pKa values of 9.03 for the first dissociation and 11.63 for the second at 25°C.^[8] As a polyphenol, pyrogallol exhibits strong reducing agent properties, attributed to the low oxidation potential of its phenolic hydroxyl groups, which readily donate electrons or hydrogen atoms in reactions.^[9]^[1] Spectroscopically, pyrogallol in aqueous solution displays an ultraviolet-visible absorption maximum at 266 nm, corresponding to π–π* transitions in the aromatic ring influenced by the hydroxyl substituents.^[10] In infrared spectroscopy, the O-H stretching vibrations appear as broad bands around 3400 cm⁻¹, shifted lower due to extensive hydrogen bonding among the adjacent hydroxyl groups.^[7]^[11]

Synthesis

Industrial production

Pyrogallol is industrially produced primarily through the thermal decarboxylation of gallic acid (3,4,5-trihydroxybenzoic acid), where the precursor is heated to 180–220 °C under controlled conditions, often in an autoclave or high-pressure vessel, to yield pyrogallol and carbon dioxide via the reaction:

\ce{C6H2(OH)3COOH ->[heat] C6H3(OH)3 + CO2}

^[12]^[13] This process is energy-intensive due to the high temperatures required but is economically viable given the availability of gallic acid. Gallic acid itself is derived from the hydrolysis of natural tannins present in plant materials such as nutgalls (from oak trees) or tara pods (Caesalpinia spinosa), which are abundant and cost-effective feedstocks.^[14]^[15]^[16] After decarboxylation, the crude pyrogallol is purified through distillation under reduced pressure to remove volatile impurities or by sublimation, which exploits its volatility to separate it from non-volatile byproducts, routinely achieving purities exceeding 98%.^[17]^[18]^[19] Global production capacity for pyrogallol is on the order of several thousand tons per year, concentrated in China and India, where it serves mainly as an intermediate in chemical synthesis and pharmaceuticals.^[20]^[21]^[22]

Laboratory preparation

Pyrogallol is commonly prepared in the laboratory by the thermal decarboxylation of gallic acid, which involves heating the dried precursor to approximately 200–220 °C, resulting in the loss of carbon dioxide to form the trihydroxybenzene structure.^[23]^[24] This method is straightforward for small-scale synthesis and typically achieves yields of around 81% when facilitated by catalysts such as pyridine at lower temperatures (e.g., 135 °C for 1–2 hours), though dry heating alone may require higher temperatures and longer reaction times of 1–2 hours.^[17] Alternative synthetic routes suitable for laboratory settings include the oxidation of 2,3-dihydroxybenzaldehyde, where the precursor undergoes selective oxidation to introduce the third hydroxyl group, yielding pyrogallol in a controlled manner.^[25] Another approach is the selective hydroxylation of catechol using hydrogen peroxide, which adds a hydroxyl group at the appropriate position to produce pyrogallol, though this method requires careful control to minimize side products. Modern laboratory preparations increasingly utilize microbial fermentation with genetically engineered bacteria, such as Escherichia coli, to convert glucose into gallic acid as an intermediate, followed by enzymatic decarboxylation to pyrogallol. This biosynthetic pathway enables gram-per-liter production under mild conditions (e.g., 30 °C, pH 5.5–7.0) and achieves yields of 70–90% from the gallic acid intermediate, offering a sustainable alternative to thermal methods.^[13]^[26]

Reactions

Oxidation reactions

Pyrogallol undergoes rapid auto-oxidation in the presence of air, especially under alkaline conditions, yielding purpurogallin as a prominent red pigment product. This process proceeds via semiquinone intermediates, where the initial step involves a one-electron oxidation of pyrogallol to form a phenoxyl radical (semiquinone), which subsequently dimerizes, undergoes further oxidation, cyclizes, and decarboxylates to purpurogallin from two molecules of pyrogallol and molecular oxygen.^[27]^[28] This transformation is significantly accelerated by trace metal ions, such as copper(II), which facilitate the generation of reactive oxygen species like superoxide that propagate the chain reaction.^[27] Electrochemical studies reveal that pyrogallol exhibits a low oxidation potential in alkaline media, with the first anodic peak observed at approximately +0.15 V versus the saturated calomel electrode (SCE), indicative of the facile one-electron transfer to the semiquinone stage. In alkaline environments, oxidation of pyrogallol initially produces galloquinone (the ortho-quinone derivative) through dehydrogenation of the vicinal trihydroxy groups, which then rapidly polymerizes via nucleophilic addition and further redox processes, resulting in complex polyphenolic structures responsible for the characteristic browning observed in solutions.

Other reactions

Pyrogallol undergoes esterification with acetic anhydride in the presence of a base such as pyridine to form triacetylpyrogallol, a common derivative used for protection of its hydroxyl groups.^[29] This reaction proceeds via nucleophilic acyl substitution at each of the three phenolic hydroxyls, yielding the triester and acetic acid as a byproduct.^[30] The balanced equation for this transformation is:

\ce{C6H3(OH)3 + 3 (CH3CO)2O -> C6H3(OCOCH3)3 + 3 CH3COOH}

^[29] Alkylation of pyrogallol occurs through reaction with alkyl halides under basic conditions, following the Williamson ether synthesis mechanism, where the deprotonated phenoxide ions act as nucleophiles to form alkyl aryl ethers.^[31] This method is particularly useful for selective protection of hydroxyl groups, as demonstrated by the preparation of pyrogallol monomethyl ether using methyl iodide or dimethyl sulfate in alkaline media.^[31] Pyrogallol forms coordination complexes with metal ions through its hydroxyl groups, notably chelating iron(III) to produce intensely colored species suitable for qualitative analysis.^[32] These complexes arise from the binding of the trihydroxybenzene moiety to the metal center, resulting in violet to blue hues depending on the stoichiometry and pH.^[33]

Applications

Photography

Pyrogallol serves as a reducing agent in alkaline developers for silver halide films, where it converts exposed silver bromide (AgBr) to metallic silver (Ag) through a redox reaction. Pyrogallol reduces exposed silver ions to metallic silver while undergoing oxidation itself. This process selectively amplifies the latent image formed by light exposure on the emulsion, producing visible metallic silver grains.^[34] Introduced to photography in the mid-19th century, pyrogallol was first noted for its rapid silver deposition from silver salts in 1832 and formally adopted as an organic developer by Henri-Victor Regnault in 1851. It played a pivotal role in early processes, including Frederick Scott Archer's wet collodion method starting in 1851, where it was used to develop exposed plates immediately after sensitization. Pyrogallol also contributed to the transition to early dry plates in the 1870s and 1880s, enabling more reliable image formation in professional and astronomical photography, such as in the Cape Photographic Durchmusterung project.^[34]^[35]^[36] Its advantages include high developing activity, which allows for quick image formation, and the production of fine grain structures with enhanced edge sharpness due to tanning effects from its oxidation products. However, pyrogallol's instability in alkaline solutions leads to rapid oxidation, necessitating fresh preparation of working solutions to avoid fogging or uneven development. By the late 19th century, it began to be supplanted by more stable alternatives like hydroquinone, discovered in 1880, which offered greater reliability and reduced preparation demands. Despite this decline, pyrogallol persists in contemporary alternative processes, such as kallitype printing, where its staining properties enhance tonal depth in iron-silver emulsions.^[37]^[38]^[39]

Analytical and industrial uses

Pyrogallol is employed as an analytical reagent for the determination of oxygen in gases, where its alkaline solution absorbs oxygen through rapid autooxidation, resulting in a characteristic color change from colorless to dark brown due to the formation of oxidation products.^[3]^[40] This property enables its use in gas analysis for qualitative detection and quantitative measurement by monitoring oxygen uptake or color intensity.^[41] Additionally, pyrogallol functions as a reductant in redox titrations.^[42] In hair dyes and cosmetics, pyrogallol undergoes oxidation to form colored polymers that contribute to tinting and coloring effects.^[43] Its use in hair dyes has been restricted or prohibited in many regions due to safety concerns. It is banned in the European Union (since 1976) and not reported in use in recent U.S. assessments (as of 2024). Where permitted, such as in Brazil, concentrations are limited to 5% (at pH 5) with warnings; typical levels are below 1%, and in Korea to less than 2% (as of 2022).^[44]^[45]^[46]^[47]^[48] Pyrogallol finds industrial applications as an antioxidant, particularly in inks where it reacts with iron salts to produce deep blue-black colors, forming the basis for traditional writing inks.^[34] It also serves as an oxygen scavenger in water treatment processes to prevent corrosion by removing dissolved oxygen.^[3] In biochemical research, pyrogallol is used to generate superoxide radicals through autoxidation, facilitating studies on oxidative stress and the activity of antioxidant enzymes like superoxide dismutase.^[9]^[49]

Safety and toxicology

Health hazards

Pyrogallol is acutely toxic upon ingestion, with an oral LD50 of approximately 800 mg/kg in rats. Acute exposure can cause gastrointestinal symptoms such as nausea and vomiting, as well as headache and shortness of breath. Dermal contact leads to rapid absorption, resulting in skin irritation and dermatitis, while inhalation irritates the respiratory tract. Additionally, pyrogallol exposure is associated with methemoglobinemia, which manifests as cyanosis and breathing difficulties due to impaired oxygen transport in the blood. Chronic exposure to pyrogallol may induce skin sensitization, leading to allergic reactions upon repeated contact. It causes serious eye irritation, potentially resulting in redness and discomfort. Pyrogallol is suspected of causing genetic defects based on in vitro and animal studies. Animal studies provide equivocal evidence of carcinogenicity, with no evidence in rats but increased incidence of skin tumors in some dermal studies in mice. Its tendency to auto-oxidize, as noted in chemical reactivity profiles, contributes to health risks through the generation of reactive oxygen species. The primary mechanism of pyrogallol's toxicity involves auto-oxidation, which produces reactive oxygen species that damage cells and tissues. In high doses, this oxidative stress can lead to hemolytic anemia through red blood cell hemolysis. Exposure occurs mainly via ingestion, which affects the gastrointestinal and systemic systems; dermal absorption, which is efficient and causes local and systemic effects; and inhalation, which primarily irritates the respiratory tract.

Regulatory status

In the European Union, pyrogallol is classified under the Classification, Labelling and Packaging (CLP) Regulation as causing serious eye irritation (Eye Irrit. 2), skin irritation (Skin Irrit. 2), and may cause an allergic skin reaction (Skin Sens. 1). It is also classified as toxic to aquatic life with long-lasting effects (Aquatic Chronic 2).^[50] Its use in cosmetics is prohibited under Annex II of Regulation (EC) No 1223/2009, with the ban effective since 1992.^[45] In the United States, pyrogallol is not assigned a permissible exposure limit (PEL) by the Occupational Safety and Health Administration (OSHA), indicating it is not specifically listed as a hazardous substance under that standard.^[51] It is, however, listed on the Toxic Substances Control Act (TSCA) Inventory as an active substance.^[52] Recommended personal protective equipment (PPE) for handling includes chemical-resistant gloves and safety goggles to prevent skin and eye contact.^[53] For safe handling, pyrogallol should be stored in a tightly closed container under an inert atmosphere, such as nitrogen, in a cool, dry place to prevent oxidation and discoloration upon exposure to air.^[1] Disposal must follow U.S. Environmental Protection Agency (EPA) guidelines for hazardous waste, with generators required to assess and classify discarded material accordingly.^[51] Internationally, the use of pyrogallol in hair dyes has declined since the 1970s following U.S. Food and Drug Administration (FDA) warnings on coal tar hair dyes, which require caution statements and patch testing for products containing such ingredients to mitigate potential risks.^[43] It remains exempt from color additive certification for specific uses like suture coloring when combined with ferric ammonium citrate, provided it meets safety criteria.^[54]

References

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Pyrogallol | C6H3(OH)3 | CID 1057 - PubChem
Pyrogallol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 3. It has a role as a plant metabolite. It is a phenolic donor and a benzenetriol.
[2]
Pyrogallol = 98 HPLC 87-66-1
### Summary of Pyrogallol (P0381) from Sigma-Aldrich
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Pyrogallol ACS reagent 87-66-1
### Summary of Physical Properties of Pyrogallol (Product #254002)
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ICSC 0770 - PYROGALLIC ACID - INCHEM
Boiling point: 309°C Melting point: 131-134°C Relative density (water = 1): 1.45. Solubility in water, g/100ml at 20°C: 60 (good) Vapour pressure, kPa at 168 ...
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Pyrogallol, 99% - Fisher Scientific
100 g. Merck Index, 15,8112. Solubility Information, Solubility in water: 400g/L (25°C). Other solubilities: 1 g/1.3 mL alcohol, 1 g/1.6 mL ether, slightly ...
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1,2,3-Benzenetriol · Formula: C6H6O · Molecular weight: 126.1100 · IUPAC Standard InChI: InChI=1S/C6H6O3/c7-4-2-1-3-5(8)6(4)9/h1-3,7-9H Copy. InChI version 1.06.
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Pyrogallol ; 1,2,3-Benzenetriol. [IUPAC name – generated by ACD/Name] ; 1,2,3-Benzènetriol. [French] ; 1,2,3-Benzoltriol. [German] ; 201-762-9. [EINECS] ; 35296-77-6.
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PhytoHub ID: PHUB000632 ; Name: Pyrogallol ; Systematic Name: 1,2,3-Trihydroxybenzene ; Synonyms. 1,2,3-Benzenetriol; 1,2,3-benzoltriol; 1,2,3-trihydroxyphenol ...
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Pyrogallol (benzene-1,2,3-triol) is a powerful reducing agent that absorbs oxygen from the air in alkaline solution. Due to its oxygen radical generating ...
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Rating 4.8 (41) Pyrogallol Market size is rising exponentially over the last years and it is expected to attain high market trends in the forecast period.Missing: volume | Show results with:volume
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... pyrogallol is prepared by the oxidation of 2,3-dihydroxybenzaldehyde. 13. The process as defined by claim 1, wherein pyrogallol and 1,2,4-trihydroxybenzene ...
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Process for producing pyrogallol and derivatives thereof
Another known process for the production of pyrogallol is hydroxylation of catechol or resorcinol with hydrogen peroxide. This technique, however, has been ...
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Apr 2, 2015 · However, it is still prepared traditionally by chemical decarboxylation of gallic acid catalyzed by high temperature or pressure (Zeida 1998) in ...
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Mechanism of pyrogallol autoxidation and determination of ...
Pyrogallol reacts with dioxygen in weakly alkaline solutions to form several intermediate products which are electroactive substance and can be detected by ...
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To this tar were added glacial acetic acid (42 parts) and acetic anhydride (70 parts) and a catalytic amount of pyridine. After standing at room temperature for ...
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Acetylation of Pyrogallol. The most direct synthesis involves acetylation of pyrogallol using acetic anhydride in the presence of a catalyst such as pyridine:.
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because of air oxidation of pyrogallol to purpurogallin, a condensation product of pyrogallol and also a product of the electroxidation of pyrogallol (3).
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Pyrogallol could form colored complexes with Fe(III) and V(V) as is shown in Fig. 1. Conclusion. The method used for some synthetic samples with different ...
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Pyrogallol is an organic compound, a phenol, used as a photographic film developer and in chemical preparation. It is also the oldest photographic developer.
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Mixing Developers - Unblinking Eye
With the discovery of hydroquinone in 1880, metol in 1891, and the subsequent invention of metol -hydroquinone formulas, pyrogallol began to fall into disfavor.
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Pyrogallol in Analytical Chemistry: Ensuring Precision in Gas Analysis
Nov 2, 2025 · When exposed to oxygen in the presence of a base, Pyrogallol readily reacts, effectively removing oxygen from a sample gas. This characteristic ...
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Spectrophotometric study of the cerium(IV)-pyrogallol red system
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Pyrogallol, a benzenetriol, is used in oxidative hair dyes at concentrations ranging from ≤0.1 to 5.0%. The oral LD50's in rats ranged from 800 to 1270 mg ...
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[PDF] Amended Safety Assessment of Pyrogallol as Used in Cosmetics
Nov 8, 2024 · The maximum concentration of use range reported in the original safety assessment was < 0.1 - 5% in hair dyes and colors; however, no uses were ...
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(PDF) Analytical Method Development and Dermal Absorption of ...
May 10, 2025 · Pyrogallol is an ingredient in hair dye. Its concentration in hair dye is managed at less than 2.0% in Korea. There have been no reports on ...
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Carcinogenic (C) – Recognised carcinogen: comes from a harmonised C&L classifying the substance as Carc. 1A or 1B and/or an entry in the Candidate list.<|separator|>
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[PDF] Pyrogallol
Nov 15, 2004 · Boiling Point: 309 deg C. Freezing/Melting Point:133 - 134 deg C. Decomposition Temperature:309 deg C. Solubility: Soluble. Specific Gravity ...
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[PDF] SAFETY DATA SHEET - Fisher Scientific
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[PDF] Material Safety Data Sheet - Pyrogallol - Cole-Parmer
CAS# 1310-58-3: Draize test, rabbit, skin: 50 mg/24H Severe;. Oral, rat: LD50 = 273 mg/kg; . Carcinogenicity: CAS# 7732-18-5: Not listed by ACGIH, IARC, NTP, or ...
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[PDF] Nomination Background: Pyrogallol (CASRN: 87-66-1)
Jan 19, 1996 · The acute oral LD50 for pyrogallol is 738 to 1800 mg/kg (5.85-14.3 mmol/kg) for rats, 1600 mg/kg (13 mmol/kg) for rabbits, 25 mg/kg (0.20 mmol/ ...