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Repaglinide

Repaglinide is an oral antihyperglycemic agent in the meglitinide (glinide) class, used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.^[1]^[2] It is not indicated for type 1 diabetes or diabetic ketoacidosis.^[2] Approved by the U.S. Food and Drug Administration in 1997 under the brand name Prandin, it is available in tablet strengths of 0.5 mg, 1 mg, and 2 mg and as a generic medication.^[2]^[3] Repaglinide lowers blood glucose levels by acting as an insulin secretagogue, binding to the sulfonylurea receptor (SUR1) subunit of ATP-sensitive potassium channels on pancreatic beta cells, which closes the channels, depolarizes the cell membrane, and stimulates insulin release in a glucose-dependent manner.^[1]^[2] This rapid onset of action (peak plasma levels within about 1 hour) and short half-life (less than 60 minutes) make it suitable for prandial dosing to target postprandial hyperglycemia.^[1] It is primarily metabolized by the liver via CYP2C8 and CYP3A4 enzymes, with about 90% excreted in feces and 8% in urine.^[2] The medication is typically administered orally 15 to 30 minutes before meals, with doses ranging from 0.5 mg to 4 mg per meal (maximum 16 mg daily), and the dose should be skipped if a meal is missed.^[1]^[4] Initial dosing is often 0.5 mg for patients with HbA1c below 8% or 1-2 mg for those with higher levels, with titration based on glycemic response and tolerance.^[2] It can be used as monotherapy or in combination with metformin or thiazolidinediones, but not with sulfonylureas.^[1]^[2] In clinical trials, repaglinide monotherapy reduced HbA1c by 1.7-2.1% over 24 weeks compared to placebo.^[2] Common adverse effects include hypoglycemia (affecting up to 31% of patients), weight gain (about 1.8 kg over 16 weeks), and upper respiratory infections.^[1]^[4] It is contraindicated in patients with hypersensitivity to repaglinide or concomitant use of gemfibrozil due to increased risk of hypoglycemia; it is not indicated for type 1 diabetes or diabetic ketoacidosis and should be used with caution in severe hepatic impairment.^[1]^[2] Caution is advised with other CYP2C8 or CYP3A4 inhibitors/inducers, and patients should monitor blood glucose regularly while avoiding excessive alcohol intake.^[4]^[2]

Medical Uses

Indications

Repaglinide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM).^[5] It is not indicated for the management of type 1 diabetes or diabetic ketoacidosis.^[5] Repaglinide is also approved for use in combination therapy with metformin or thiazolidinediones to lower blood glucose levels in patients with T2DM whose hyperglycemia cannot be adequately controlled by diet and exercise alone.^[6] Clinical studies have demonstrated that such combinations enhance glycemic control, with repaglinide plus metformin reducing HbA1c by approximately 1.4% and fasting plasma glucose by 2.2 mmol/L compared to metformin monotherapy.^[7] Evidence from randomized clinical trials supports repaglinide's efficacy in reducing fasting plasma glucose and postprandial glucose levels. In one placebo-controlled trial involving patients with T2DM, repaglinide monotherapy decreased mean HbA1c from 8.5% to 7.8% and lowered fasting plasma glucose, while postprandial glucose excursions were also significantly reduced.^[8] Additional studies report average reductions in fasting plasma glucose of 3.1–3.4 mmol/L and postprandial glucose of approximately 5.8 mmol/L with repaglinide treatment.^[1] Compared to sulfonylureas, repaglinide demonstrates equivalent overall antidiabetic efficacy in improving glycemic control but offers a more rapid onset of action, making it particularly suitable for mealtime dosing to target postprandial hyperglycemia.^[9] This pharmacokinetic profile allows for flexible administration aligned with meals, mirroring the physiologic insulin response more closely than the longer-acting sulfonylureas.^[10]

Administration and Dosage

Repaglinide is available in oral tablet form in strengths of 0.5 mg, 1 mg, and 2 mg.^[2] The recommended initial dose for adults with type 2 diabetes mellitus is 0.5 mg taken orally within 30 minutes before each meal for patients with HbA1c less than 8% or those not previously treated with blood glucose-lowering agents; for patients with HbA1c of 8% or greater or those previously treated, the initial dose is 1 mg or 2 mg before each meal.^[2] Dosing should be individualized based on the patient's meal pattern, typically administered two, three, or four times daily, with a maximum of 4 mg per meal and a total daily maximum of 16 mg.^[2] Dose titration involves doubling the preprandial dose until satisfactory glycemic control is achieved, with adjustments assessed after at least one week of treatment and guided by monitoring of fasting blood glucose and HbA1c levels.^[2]^[11] If a meal is skipped, the corresponding repaglinide dose should be omitted to avoid hypoglycemia; doses should not be doubled to compensate for missed administrations.^[2] Repaglinide is intended for long-term use in the chronic management of type 2 diabetes, with periodic reassessment of glycemic control to determine the need for dose adjustments or continuation of therapy.^[1]

Safety Profile

Contraindications

Repaglinide is contraindicated in patients with diabetic ketoacidosis, as the medication does not correct the underlying acidosis and may potentially worsen the condition by inducing hypoglycemia without addressing ketogenesis.^[1] This acute complication of diabetes requires immediate insulin therapy to restore metabolic balance, rendering repaglinide ineffective and unsafe.^[2] The drug is also contraindicated in type 1 diabetes mellitus, where patients lack adequate endogenous insulin production from pancreatic beta cells for repaglinide to stimulate its release.^[1] Repaglinide's mechanism relies on closing ATP-sensitive potassium channels in functional beta cells to trigger insulin exocytosis, which cannot occur in the absence of these cells.^[12] Known hypersensitivity to repaglinide or any of its components represents an absolute contraindication due to the risk of severe allergic reactions, including anaphylaxis.^[2] Severe hepatic impairment is a contraindication per EMA guidelines (defined as severe hepatic function disorder, such as Child-Pugh class C), because repaglinide undergoes extensive hepatic metabolism via CYP3A4 and CYP2C8 enzymes, leading to prolonged systemic exposure and heightened risk of severe hypoglycemia in such patients.^[12] The U.S. FDA recommends caution rather than contraindication, with careful monitoring.^[2] Pharmacokinetic studies have demonstrated significantly elevated area under the curve (AUC) values in individuals with chronic liver disease at this severity level.^[13] Concomitant administration with gemfibrozil is strictly contraindicated, as this fibrate inhibits repaglinide's metabolism by CYP2C8, resulting in an approximately eightfold increase in repaglinide exposure and a substantial risk of severe, prolonged hypoglycemia.^[2] Clinical data confirm this interaction's potency, with multiple reports of life-threatening hypoglycemic events.^[14]

Adverse Effects

Repaglinide, like other insulin secretagogues, is associated with a range of adverse effects, primarily related to its mechanism of stimulating insulin release, with hypoglycemia being the most frequent and clinically significant issue observed in clinical trials. In controlled studies involving over 4,000 patients, the overall incidence of adverse events was comparable to placebo or sulfonylureas, but specific effects varied by duration and combination therapy.^[2]

Common Adverse Effects

The most prevalent adverse effect is hypoglycemia, occurring in 16% to 31% of patients depending on trial duration and symptomatic reporting; mild to moderate episodes affected 31% in short-term studies, while symptomatic hypoglycemia was noted in 16% over one year. This risk increases with skipped meals, excessive alcohol consumption, or intense exercise, and is more pronounced in combination with insulin or other antidiabetics. Other common effects (incidence 5-10%) include upper respiratory tract infections (16%), headache (10-11%), nausea (5%), diarrhea (5%), sinusitis (6%), arthralgia (6%), and back pain (5%). Weight gain is also frequently reported, averaging 3.3% body weight increase (approximately 3-4 kg over 6 months) in monotherapy, and up to 5.5 kg when combined with thiazolidinediones like pioglitazone.^[2]^[15]

Serious Adverse Effects

Cardiovascular events, such as myocardial ischemia, have been reported in 1.4% of patients in trials combining repaglinide with NPH-insulin, with six serious cases across seven studies, though overall cardiovascular adverse event rates (4%) were similar to sulfonylureas (3%). Rare but serious effects (<1% incidence) include elevated liver enzymes, thrombocytopenia, leukopenia, and anaphylactoid reactions manifesting as rash or severe allergic responses. In post-marketing surveillance, additional infrequent events include pancreatitis, hemolytic anemia, alopecia, Stevens-Johnson syndrome, and severe hepatic dysfunction (e.g., jaundice or hepatitis), though causality is not always established due to voluntary reporting.^[2]

Management Strategies

For hypoglycemia, immediate management involves oral carbohydrates for mild cases; severe episodes may require glucagon (1 mg subcutaneously) or intravenous glucose, with dose reduction or skipping the dose recommended if meals are missed. Patients with a history of cardiovascular disease should undergo regular monitoring for ischemic events, particularly when combining repaglinide with insulin. Certain drug interactions, such as with gemfibrozil, can potentiate hypoglycemia and necessitate dose adjustments. Overall, periodic assessment of fasting glucose and HbA1c helps mitigate risks.^[2]^[1]

Drug Interactions

Repaglinide undergoes primary hepatic metabolism via the cytochrome P450 enzyme CYP3A4, which influences its interactions with various drugs that modulate this pathway.^[2] CYP3A4 inhibitors, such as ketoconazole and itraconazole, can modestly increase repaglinide exposure (e.g., ketoconazole raises AUC by approximately 15% and Cmax by 16%, while itraconazole increases AUC 1.4-fold and Cmax 1.5-fold), thereby heightening the risk of hypoglycemia.^[2] Due to this amplified exposure, concomitant use requires dose reduction of repaglinide and close monitoring of blood glucose levels to prevent severe hypoglycemia.^[16] In contrast, CYP3A4 inducers like rifampin decrease repaglinide plasma concentrations by 50% to 80%, potentially diminishing its glucose-lowering efficacy.^[2] Rifampin specifically reduces repaglinide AUC by 32% to 80% and Cmax by 17% to 79%, necessitating careful glycemic monitoring and possible dose escalation to maintain therapeutic control.^[2] Gemfibrozil, a fibrate that inhibits the organic anion-transporting polypeptide 1B1 (OATP1B1) transporter and CYP2C8, markedly elevates repaglinide levels, increasing AUC by up to 8-fold and prolonging its half-life to 3-4 hours, which substantially raises the risk of hypoglycemia.^[16]^[17] This interaction renders concomitant use contraindicated, with recommendations to avoid gemfibrozil entirely in patients taking repaglinide and consider alternative fibrates like fenofibrate if lipid management is needed.^[2]^[17] Beta-blockers, such as propranolol and metoprolol, can mask the symptoms of hypoglycemia (e.g., tachycardia and tremors) induced by repaglinide, complicating timely recognition and response to low blood glucose.^[18] They may also potentiate the hypoglycemic effect, warranting cautious use with enhanced blood glucose monitoring and potential dose adjustments.^[16] Alcohol consumption potentiates the risk of hypoglycemia when combined with repaglinide, as it can exacerbate blood glucose instability and lead to severe episodes.^[18] Patients are advised to consume alcohol in moderation and monitor glucose levels closely during such use.^[16] Overall clinical recommendations emphasize individualized dose adjustments and frequent blood glucose monitoring for patients on repaglinide encountering these interacting agents to optimize safety and efficacy.^[2] Healthcare providers should review concomitant medications and consider therapeutic alternatives where interactions pose significant risks.^[17]

Use in Special Populations

Repaglinide's use requires careful consideration in pregnant patients due to limited human data and potential risks associated with maternal hypoglycemia. The FDA prescribing information indicates that available case reports and observational data do not suggest an increased risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes directly attributable to repaglinide, though poorly controlled diabetes in pregnancy itself poses significant risks such as ketoacidosis and congenital malformations. Animal reproduction studies showed no teratogenic effects at exposures up to 60 times the maximum recommended human dose in rats and 1 time in rabbits, but higher doses led to developmental delays. Given these uncertainties, repaglinide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, with insulin generally preferred for glycemic control in this population.^[2] For breastfeeding individuals, repaglinide is not recommended due to the potential for hypoglycemia in the nursing infant. Although no data exist on its transfer into human milk, animal studies demonstrate that repaglinide is excreted in rat milk, resulting in reduced pup blood glucose levels and skeletal abnormalities at high doses. The drug's high protein binding (>98%) suggests minimal passage into breast milk, but the risk of serious adverse effects in infants warrants avoidance or discontinuation of nursing if repaglinide is necessary.^[2]^[19] Repaglinide is not approved for use in pediatric patients under 18 years of age, as safety and efficacy have not been established in this population. No clinical studies have evaluated its pharmacokinetics, pharmacodynamics, or long-term effects in children or adolescents with type 2 diabetes.^[2]^[1] In geriatric patients, repaglinide can be used without routine dose adjustments, but caution is advised due to the potential for increased sensitivity to hypoglycemic effects stemming from age-related declines in renal and hepatic function. Clinical trials involving over 400 patients aged 65 years and older showed no overall differences in safety or efficacy compared to younger adults, though individual variability may necessitate closer monitoring and conservative titration starting at the standard 0.5 mg dose before meals.^[2] Patients with renal impairment require dose adjustments based on severity to mitigate the risk of accumulation and hypoglycemia. No initial adjustment is needed for mild to moderate impairment (creatinine clearance 40–80 mL/min), but careful monitoring of blood glucose is essential. In severe impairment (creatinine clearance 20–40 mL/min), therapy should begin at 0.5 mg before meals with cautious titration; repaglinide has not been studied in patients with creatinine clearance below 20 mL/min or on dialysis, and its use is not recommended in end-stage renal disease due to limited data. Clinical studies confirm repaglinide's tolerability in renal impairment, with no disproportionate increase in adverse events compared to patients with normal function.^[2]^[20] Hepatic impairment increases repaglinide's plasma concentrations and prolongs its half-life, heightening hypoglycemia risk, so use is limited to mild cases with close monitoring. In moderate to severe hepatic dysfunction, higher and more prolonged serum levels have been observed in single-dose studies, necessitating longer intervals between dose adjustments and potentially reduced dosing; repaglinide is contraindicated in severe cases per EMA (e.g., Child-Pugh class C), while FDA advises caution unless benefits outweigh risks.^[2]^[12]

Pharmacology

Mechanism of Action

Repaglinide is a meglitinide-class oral antidiabetic agent that lowers blood glucose levels by stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner. It specifically binds to the sulfonylurea receptor 1 (SUR1) subunit of ATP-sensitive potassium channels (KATP) located on the surface of beta cells in the islets of Langerhans. This binding inhibits the efflux of potassium ions through the KATP channels, leading to their closure.^[1]^[16] The closure of KATP channels causes membrane depolarization in the beta cells, which activates voltage-gated calcium channels and results in an influx of calcium ions into the cell. This increase in intracellular calcium concentration triggers the exocytosis of insulin-containing granules, thereby promoting the rapid release of insulin into the bloodstream. Unlike non-glucose-dependent secretagogues, repaglinide's action is tightly coupled to the presence of extracellular glucose; it enhances insulin secretion primarily when glucose levels are elevated, such as in the postprandial state, with maximal effects observed at glucose concentrations of 3–10 mmol/L and minimal activity at levels below 3 mmol/L or above 15 mmol/L. This glucose dependency helps mitigate the risk of hypoglycemia by preventing inappropriate insulin release during normoglycemia or hypoglycemia.^[16]^[1] In comparison to longer-acting sulfonylureas, which bind more tightly to SUR1 and sustain channel closure for extended periods, repaglinide exhibits a higher dissociation rate from the receptor, contributing to its brief duration of action (typically 4–6 hours of elevated insulin levels). This rapid on-off kinetics allows for targeted stimulation of early-phase insulin secretion, particularly effective for controlling postprandial hyperglycemia without prolonged suppression of hepatic glucose production.^[16]^[21]

Pharmacokinetics

Repaglinide exhibits rapid absorption after oral administration, achieving peak plasma concentrations (Cmax) within 1 hour (Tmax). Its mean absolute bioavailability is approximately 56%, indicating substantial first-pass metabolism.^[2] The drug is extensively distributed, with a volume of distribution at steady state (Vss) of 31 L and highly bound to plasma proteins (>98%, primarily albumin). Total body clearance is 38 L/h.^[2] Repaglinide undergoes complete hepatic metabolism via oxidative biotransformation by cytochrome P450 enzymes CYP3A4 and CYP2C8, as well as glucuronidation, yielding inactive metabolites such as the oxidized dicarboxylic acid (M2, ~60% of dose) and aromatic amine (M1) derivatives. These pathways render it susceptible to drug interactions with CYP modulators.^[2]^[22] Elimination occurs predominantly through biliary excretion into feces (90% of dose recovered within 96 hours), with minimal renal clearance (<8%, and <0.1% as unchanged drug). The plasma elimination half-life is approximately 1 hour (range 0.4–8.0 hours), facilitating flexible prandial dosing without significant accumulation.^[2] Food intake influences absorption; a standard meal reduces Cmax by 20% and area under the curve (AUC) by 12.4%, with no change in Tmax. Repaglinide is therefore administered 15 minutes before meals to optimize glycemic control.^[2]

Chemistry

Chemical Structure

Repaglinide is a carbamoylmethyl benzoic acid derivative belonging to the meglitinide class of antidiabetic agents.^[23] Its IUPAC name is (2S)-2-ethoxy-4-[2-[[(3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid, reflecting a benzoic acid core substituted at the 2-position with an ethoxy group and at the 4-position with a 2-(alkylamino)-2-oxoethyl chain that incorporates a piperidine ring and a branched butyl group.^[23] The molecular formula is C27H36N2O4, with a molecular weight of 452.6 g/mol.^[23] The structure features a central benzoic acid moiety linked via an amide (carbamoyl) group to a chiral carbon bearing a 3-methylbutyl chain and a 2-(piperidin-1-yl)phenyl substituent.^[23] Repaglinide is the active S-enantiomer, with the chiral center at the amide-bearing carbon exhibiting the S configuration; the R-enantiomer lacks significant hypoglycemic activity.^[24]^[25]

Physical Properties

Repaglinide appears as a white to off-white crystalline powder, which is characteristic of its solid form used in pharmaceutical formulations.^[26]^[27] The compound exhibits poor solubility in water, with a reported value of less than 0.2 mg/mL (approximately 0.034 mg/mL at 37°C), classifying it as practically insoluble; however, it is freely soluble in organic solvents such as methanol and acetone.^[28]^[29] Its pKa values are 3.9 for the carboxylic acid group and 6.0 for the amine group, influencing its ionization behavior in physiological environments.^[30] Repaglinide demonstrates sensitivity to light and moisture, necessitating storage in airtight, light-resistant containers at room temperature to maintain stability.^[27]^[31] The partition coefficient (logP) is approximately 4.0, reflecting its lipophilic nature that facilitates crossing biological membranes and contributes to its oral absorption profile.^[32] Its melting point ranges from 130°C to 131°C.^[23]^[16]

Development and Regulation

History

Repaglinide was invented in 1983 by scientists at Dr. Karl Thomae GmbH, a subsidiary of Boehringer Ingelheim, as part of efforts to develop novel insulin secretagogues. The compound was licensed to Novo Nordisk, which advanced its development in the early 1990s as a short-acting meglitinide intended to address limitations of sulfonylureas, including their longer duration of action and risk of sustained hypoglycemia, by enabling prandial dosing for better postprandial glucose control.^[33]^[34]^[35]^[36] Preclinical studies in animal models, including rats and dogs, confirmed repaglinide's rapid onset of action and potent stimulation of insulin secretion from pancreatic beta cells, with effective blood glucose lowering at low doses (ED50 ≈ 0.01 mg/kg in rats) and favorable pharmacokinetic profile involving hepatic metabolism.^[36]^[37]^[38] Phase III clinical trials in the mid-1990s, involving multiple controlled studies with over 1,500 patients, established repaglinide's efficacy in improving postprandial glycemic control, demonstrating reductions in peak postprandial glucose of approximately 5.8 mmol/L and superiority over glibenclamide in short-term assessments.^[39]^[40]^[36] The U.S. Food and Drug Administration approved repaglinide on December 22, 1997, as Prandin for the management of type 2 diabetes mellitus, including monotherapy and combination therapy with metformin. The European Medicines Agency followed with approval on August 17, 1998, under the brand name NovoNorm for similar indications.^[41]^[42] Post-approval developments included expansion of indications in 2002 to encompass combinations with thiazolidinediones such as rosiglitazone and pioglitazone, based on studies showing additive glycemic benefits. The original compound patent expired on March 14, 2009, enabling the market entry of generic formulations.^[43]^[44]

Intellectual Property and Availability

Novo Nordisk held the original U.S. patent for repaglinide, U.S. Patent No. 5,312,924, which covered the compound and its preparation and expired on March 14, 2009. This expiration followed a patent term extension granted in 2001, originally set to end in September 2006.^[5] Generic versions of repaglinide entered the U.S. market following FDA approvals starting in 2013, after the resolution of patent disputes. Caraco Pharmaceutical Laboratories (now part of Sun Pharma) received final FDA approval for its generic repaglinide tablets (0.5 mg, 1 mg, and 2 mg) on July 11, 2013, making it eligible for 180 days of exclusivity.^[45] Subsequent approvals included Perrigo's generic in January 2014 for 1 mg and 2 mg strengths, following its earlier launch of the 0.5 mg version in 2013, and Mylan's launch of the full range in January 2014.^[46]^[47] Teva Pharmaceuticals also markets a generic version, approved around the same period.^[48] Repaglinide is marketed under various brand names globally, including Prandin in the United States, NovoNorm in Europe and other regions, and GlucoNorm in Canada.^[49]^[50] Patent litigation in the 2000s and early 2010s involved challenges from generic manufacturers against Novo Nordisk's secondary patents, particularly U.S. Patent No. 6,677,358, which covered the use of repaglinide in combination with metformin and was listed in the FDA's Orange Book with a broad use code. In Caraco Pharmaceutical Laboratories, Ltd. v. Novo Nordisk A/S (2012), the U.S. Supreme Court ruled unanimously that generic companies could use counterclaim provisions under the Hatch-Waxman Act to challenge and correct misleading patent use codes, facilitating earlier generic entry.^[51] Similar disputes with Mylan and others were settled or resolved in ways that allowed generic approvals post-2009 compound patent expiration.^[52] Repaglinide is approved and available in over 90 countries worldwide, with low-cost generic versions enhancing access in many developing regions.^[49]

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NovoNorm | European Medicines Agency (EMA)
NovoNorm is used in patients who have type 2 diabetes (non-insulin-dependent diabetes). It is used together with diet and exercise to lower blood glucose ( ...
[42]
Prandin (Repaglinide) Approved for Combination Therapy With Ins
May 6, 2002 · The new indication for Prandin is important because combination therapy may improve control of blood glucose levels for many people with type 2 ...
[43]
Caraco Pharmaceutical Laboratories, Ltd. v. Novo Nordisk A/S
The patent for the composition of repaglinide expired on March 14, 2009, but Novo holds U.S. Patent No. 6,677,358 (the “358 patent”) for the use of repaglinide ...
[44]
Repaglinide - Wikipedia
Contraindications. Repaglinide is contraindicated in people with: Diabetic ketoacidosis, with or without coma. Type 1 diabetes.
[45]
[PDF] Repaglinide Tablets USP, 1 mg and 2 mg. - accessdata.fda.gov
Jul 11, 2013 · 6,677,358 (the '358 patent) is scheduled to expire on June 12, 2018. Your ANDA contains a paragraph IV certifications under section. 505(j)(2)(A ...Missing: expanded combinations 2001
[46]
Perrigo Receives FDA Final Approval For Generic Equivalent To ...
Jan 24, 2014 · Perrigo previously launched the 0.5 mg strength in 2013. Prandin® tablets (repaglinide tablets), are indicated as an adjunct to diet and ...Missing: Mylan Teva
[47]
Mylan Launches Generic Prandin® Tablets
Jan 23, 2014 · Mylan Pharmaceuticals Inc. has launched Repaglinide Tablets, 0.5 mg, 1 mg and 2 mg. This product is the generic version of Novo Nordisk's Prandin.Missing: Teva | Show results with:Teva
[48]
Generic Drug Approvals for 2013 - Drugs.com
Approved: January 25, 2013 - Teva Pharmaceuticals USA Inc. Generic for ... Approved: March 25, 2013 - Mylan Pharmaceuticals, Inc. Generic for: Trilipix ...
[49]
Dainippon Sumitomo Pharma submits an application for partial ...
Dec 25, 2013 · Repaglinide is approved and marketed in over 90 countries around the world, under the brand name "Prandin®" in the United States and "NovoNorm®" ...
[50]
Prandin Side Effects and Uses - Israel Pharmacy
Free delivery over $99Gluconorm®/Prandin®/Novonorm®/Repaglinide® (repaglinide) stimulates the pancreas to release insulin, which is needed to break down sugars in food.
[51]
Caraco Pharmaceutical Laboratories, Ltd. v. Novo Nordisk A/S
Apr 17, 2012 · Novo originally owned a patent for the repaglinide compound, known as the '035 patent, but it expired in 2009. In 2004, Novo also acquired a ...
[52]
[PDF] Case 3:09-cv-02445-FLW-DEA Document 49 Filed 03/31 ... - GovInfo
May 19, 2009 · § 271(e)(2), alleging that the filing of Mylan's ANDA for a generic version of oral repaglinide tablets infringes the '358 patent. Mylan ...