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Agent Blue

Agent Blue was an herbicide utilized by the United States military during the Vietnam War from 1962 to 1971, consisting primarily of cacodylic acid (dimethylarsinic acid), an organoarsenic compound designed to inhibit plant growth by disrupting metabolic processes.^[1]^[2] Unlike other rainbow herbicides such as Agent Orange, which contained phenoxyacetic acids contaminated with dioxins, Agent Blue was applied mainly for crop destruction, targeting rice paddies and grassy vegetation to deny food and cover to North Vietnamese and Viet Cong forces.^[3]^[4] Initially deployed as a powder and later as a liquid, it was disseminated via hand sprayers, truck-mounted equipment, and aerial applications, with approximately 1.4 million U.S. gallons sprayed over targeted areas in South Vietnam.^[1]^[5] The agent's efficacy against monocotyledonous plants like rice stemmed from its arsenic content, which interfered with photosynthesis and enzyme function, leading to rapid desiccation of foliage.^[3] While it lacked the dioxin impurities associated with long-term endocrine disruption in other agents, Agent Blue's arsenic-based formulation raised concerns over soil and water contamination, as arsenic persists in the environment and bioaccumulates, potentially contributing to carcinogenic risks in exposed populations.^[6]^[7] Military records indicate its use complemented broader defoliation efforts, though it comprised a smaller volume compared to Agent Orange, reflecting a targeted strategy for food denial rather than widespread forest clearance.^[4]^[6] Post-war assessments have highlighted uneven scrutiny of its legacy, with studies documenting elevated arsenic levels in sprayed regions and associated health outcomes, underscoring the challenges of attributing causality amid confounding wartime exposures.^[8]^[7]

Chemical Composition and Properties

Formulation and Active Ingredients

Agent Blue was a liquid herbicide formulation primarily containing cacodylic acid ((CH₃)₂As(O)OH) and its sodium salt, sodium cacodylate ((CH₃)₂AsO₂Na), as active ingredients.^[9]^[10] These organoarsenic compounds, both pentavalent arsenic derivatives, functioned as nonselective contact herbicides effective against grasses and broadleaf plants, particularly rice crops.^[3]^[10] The standard military formulation, based on the commercial product Phytar 560-G produced by the Ansul Company, included 4.7% cacodylic acid and 26.4% sodium cacodylate by weight, with the balance comprising 59.5% water, 5.5% sodium chloride, 3.4% surfactant, and 0.5% antifoam agent.^[10] This composition yielded approximately 12.7% total arsenic content and a specific gravity of 1.32 at 25°C, resulting in about 3.1 pounds (1.4 kg) of active ingredient per gallon (3.8 L).^[10] Initially deployed as a powder mixed with water in the field, Agent Blue transitioned to this ready-to-use liquid form to streamline application during operations.^[9]^[11] Cacodylic acid, a hygroscopic colorless solid with a garlic-like odor, exhibits high water solubility (66 g/100 g at 25°C) and phytotoxicity at concentrations as low as 200 ppm, enabling rapid foliar absorption and translocation within plants via xylem and phloem tissues.^[10] Sodium cacodylate, its water-soluble salt, complemented the acid in providing the herbicidal efficacy, with the combined actives delivering 370 g of arsenic-based material per liter in tactical preparations.^[12]^[10] No additional systemic additives or contaminants beyond these components were reported in declassified military specifications.^[3]

Mechanism of Action

Agent Blue exerts its herbicidal effects primarily through its active ingredient, cacodylic acid (dimethylarsinic acid), which acts as a non-selective contact herbicide targeting foliage.^[13] Upon application, it induces rapid desiccation and necrosis of green tissues by disrupting cellular metabolism in plants.^[14] Unlike systemic herbicides, cacodylic acid exhibits limited translocation within the plant, primarily affecting contacted surfaces, though some studies indicate efficient movement to meristematic tissues such as terminal buds and expanding leaves when applied foliarly.^[15]^[16] At the biochemical level, cacodylic acid's phytotoxicity stems from arsenic's interactions with plant enzymes and metabolic pathways. As a pentavalent arsenic compound, it competes with phosphate for uptake via plant phosphate transporters, leading to interference in phosphorylation processes essential for energy transfer and ATP synthesis.^[17] Additionally, it binds to sulfhydryl (-SH) groups in proteins, inhibiting critical enzymes involved in cellular respiration and photosynthesis, which results in halted growth, stunting, and tissue death.^[17]^[18] This mode of action manifests visible symptoms such as marginal leaf burn, tip die-back, and severe stunting within 3-4 days in dicotyledons, and rapid inhibition in monocots like rice and oats at tissue concentrations as low as 0.5-5 ppm.^[16] The compound's efficacy as a crop-denial agent relied on these rapid, foliage-specific effects, rendering treated vegetation non-viable for sustenance without deep root penetration.^[19]

Physical Characteristics

Agent Blue was formulated as a mixture of cacodylic acid ((CH₃)₂AsO₂H) and sodium cacodylate (C₂H₆AsNaO₂) in water. The herbicide was initially supplied in powder form from 1962 to 1964, requiring dilution with water prior to application via spraying. Starting in 1964, it was provided and used as a ready-to-deploy liquid aqueous solution.^[20]^[3]^[21] The primary active ingredient, cacodylic acid, is a white to colorless crystalline solid that is odorless. It exhibits a melting point of 195–196 °C, a density greater than 1.1 g/cm³, and solubility in water of approximately 66.7 g/100 mL at room temperature. These properties rendered the liquid formulation suitable for aerial dispersion, forming a clear solution without distinctive color or scent.^[22]^[23]

Development and Procurement

Origins in Agricultural Research

Cacodylic acid (dimethylarsinic acid) and its sodium salt, sodium cacodylate, the primary active ingredients in Agent Blue, originated from organic arsenical compounds researched and applied in agriculture as non-selective herbicides and plant desiccants. These substances were utilized for weed control in cotton fields, turf management, golf courses, and forestry, where they functioned by disrupting cellular processes in plants to induce rapid desiccation without soil persistence typical of some systemic herbicides.^[10]^[24] By the mid-20th century, such arsenicals had been employed extensively in U.S. agriculture, with applications including post-harvest drying of crops and edging along sidewalks and driveways, reflecting their development through empirical testing in agronomic settings rather than novel military innovation.^[10]^[25] Commercial formulations like Phytar 560G, which contained approximately 26.4% sodium cacodylate and 4.7% cacodylic acid by weight, were produced by the Ansul Chemical Company starting in the late 1950s, building on earlier synthesis methods dating back to the 19th century but adapted for pesticidal efficacy.^[26]^[10] Agricultural research demonstrated their utility in selective grass control and woody vegetation suppression, with field trials confirming effectiveness at rates of 370 grams active ingredient per liter when applied in aqueous solutions directly to foliage or soil.^[12]^[27] Domestic usage of cacodylic acid equivalents reached 1.3 to 1.7 million pounds annually by 1973, underscoring pre-existing agricultural reliance predating Vietnam-era military scaling.^[28] The transition from agricultural to tactical use stemmed from these compounds' proven phytotoxic properties, identified through USDA and industry testing for crop protection and silviculture, rather than de novo development for warfare.^[25]^[10] Unlike phenoxyacetic acid herbicides like 2,4-D, which emerged from wartime research but found postwar agricultural dominance, arsenicals like cacodylic acid exemplified earlier pesticidal applications of arsenic chemistry, with origins traceable to 19th-century inorganic arsenates repurposed into organoarsenicals for targeted plant control.^[24] This agricultural foundation provided the U.S. military with a readily available, contact-acting agent suitable for rapid crop denial, bypassing extensive new R&D.^[9]

Military Adoption and Production

The U.S. military adopted Agent Blue in 1962 as an arsenical herbicide specifically for crop destruction operations in Vietnam, marking it as one of the initial tactical herbicides deployed alongside Agent Purple.^[9] The first recorded aerial application occurred in November 1962 by the U.S. Air Force, targeting rice paddies to deny food supplies to enemy forces as part of early food denial strategies.^[29] This adoption aligned with the broader Department of Defense (DOD) herbicide program, which expanded from defoliation to include anti-crop measures, with Agent Blue's rapid desiccation effect on grasses like rice proving effective for non-woody targets where phenolic herbicides like Agent Orange were less suitable.^[30] Production of Agent Blue was handled by the Ansul Chemical Company in Marinette, Wisconsin, which formulated the herbicide as a liquid concentrate containing approximately 370 grams per liter of cacodylic acid (both free acid and sodium salt forms) for military procurement.^[31] The DOD procured commercial-grade stocks adapted for tactical use, shipping them in 208-liter barrels via ocean vessels through the St. Lawrence Seaway to South Vietnam.^[8] Over the course of the program, more than 1.1 million gallons were dispensed, with an estimated 4.6 million liters applied between 1962 and 1965 alone, reflecting scaled-up production to support intensified operations.^[9]^[31] Unlike dioxin-contaminated Agents Orange and Purple, Agent Blue's arsenic-based composition avoided similar manufacturing impurities, relying on established agricultural synthesis processes.^[9]

Military Use and Deployment

Operational Timeline

Agent Blue was initially deployed by U.S. forces in Vietnam in 1962 as part of the early herbicide operations under Operation Ranch Hand, alongside Agent Purple, to control vegetation and deny food resources to enemy combatants.^[9] Ground-based application methods, including hand sprayers and truck-mounted dispensers, were commonly employed for targeting rice paddies, bamboo thickets, and base perimeters, reflecting its role in tactical crop destruction rather than large-scale aerial defoliation.^[30] This marked the herbicide program's expansion following President Kennedy's authorization in late 1961, with Agent Blue's arsenic-based formulation selected for its rapid contact action on grassy crops.^[9] Use escalated during the mid-1960s amid U.S. military buildup, particularly in the Mekong Delta, where it supported food denial campaigns against Viet Cong supply lines by destroying rice fields essential to insurgent sustenance.^[21] By 1965, as the conflict intensified, Agent Blue shipments via ocean vessels to South Vietnamese ports enabled sustained ground and limited aerial applications, with an estimated 3.2 million liters dispersed primarily on agricultural targets and mangrove areas.^[32] Operations focused on precise denial of staple crops, contrasting with broader defoliants like Agent Orange, and continued through peak combat years (1966–1969) to disrupt enemy logistics.^[21] Deployment persisted into the early 1970s, with applications tapering as U.S. involvement waned, culminating in the herbicide program's termination in 1971 amid international scrutiny and shifting tactics.^[30] Final sprays targeted residual vegetation threats, after which remaining stocks were phased out, ending Agent Blue's combat role after nearly a decade of intermittent but strategically focused use.^[9]

Application Methods and Scale

Agent Blue was deployed primarily through aerial application methods as part of the U.S. military's Operation Ranch Hand, utilizing fixed-wing aircraft such as UC-123 Provider planes and helicopters for dispersion over targeted agricultural areas.^[9] These operations focused on rice paddies in the Mekong Delta and Central Highlands, as well as mangrove forests, to destroy food crops supporting enemy forces, with spraying timed to coincide with planting or maturation stages for maximum disruption.^[33] Ground-based methods supplemented aerial efforts, involving directed spraying from vehicles or handheld equipment to control vegetation along base perimeters, lines of communication, and defensive positions, often in areas inaccessible to aircraft.^[34] Military records indicate that over 1.1 million gallons of Agent Blue were dispensed in Vietnam from 1962 to 1971, representing about 20% of the non-Orange herbicides used in the program.^[9] Roughly 50% of this volume targeted crop destruction in remote or enemy-held territories, while the remainder supported tactical vegetation management near U.S. and allied installations.^[34] Applications were typically undiluted, at rates of approximately 3 gallons per acre, achieving rapid desiccation of rice plants within days due to the contact herbicide's arsenic-based formulation.^[9] This scale was smaller than that of defoliants like Agent Orange but prioritized precision in food denial over broad-area defoliation.^[9]

Strategic Effectiveness

Crop Denial Operations

Crop denial operations involving Agent Blue aimed to deprive Viet Cong and North Vietnamese Army forces of food supplies by targeting staple crops, particularly rice, which constituted the primary sustenance for insurgents in rural South Vietnam.^[9] These missions began in November 1962, as part of a broader U.S. strategy to disrupt enemy logistics through resource denial, with Agent Blue selected for its efficacy against hardy, narrow-leafed grasses like rice that resisted phenoxy-based herbicides such as Agent Orange.^[35] Targets were meticulously screened at multiple command levels to prioritize areas supporting enemy-held territories, focusing on paddies in all four military regions of South Vietnam.^[36]^[9] Application occurred primarily via aerial spraying from fixed-wing aircraft, often timed just before harvest to maximize destruction of standing crops and render soil unproductive for subsequent planting seasons due to arsenic residue.^[33] Approximately 300,000 hectares of rice paddies were treated with Agent Blue, accounting for roughly half of its total deployment volume during the war.^[37] Rice fields, reliant on flooded conditions, proved particularly vulnerable, as the herbicide rapidly desiccated plants within hours, preventing maturation and yield while avoiding the need for incendiary methods that were logistically challenging in wet environments.^[30]^[38] These operations extended to other food sources like bamboo and grains, but rice remained the core focus, with Agent Blue's dimethylarsinic acid formulation proving superior for grass-like monocots over broadleaf defoliants.^[9] Deployment peaked alongside overall Ranch Hand missions but tapered after 1965, as policy shifts emphasized defoliation over crop destruction amid concerns over civilian impacts and international scrutiny.^[38] Effectiveness was gauged by post-spray assessments showing near-total crop loss in targeted zones, though enemy adaptation through crop relocation and foraging mitigated some gains.^[39]

Contribution to War Efforts

Agent Blue played a targeted role in U.S. military strategy during the Vietnam War by facilitating crop destruction operations aimed at disrupting enemy food supplies, particularly rice paddies that sustained [Viet Cong](/page/Viet Cong) and North Vietnamese Army forces. Approximately half of all Agent Blue deployments were dedicated to these missions, making it the preferred herbicide for grasses and grains due to its rapid contact-killing action on rice crops.^[9] This resource denial approach, initiated as early as November 1961, sought to undermine insurgent logistics by compelling local populations to relocate from contested rural areas, thereby reducing civilian support for guerrilla operations and exposing enemy movements for targeted strikes.^[40]^[30] In operational terms, the spraying of roughly 3.2 million liters of Agent Blue—equivalent to about 845,000 gallons—across rice fields in the northern two-thirds of South Vietnam from 1962 to 1971 contributed to temporary control over agricultural output in key regions, forcing adversaries to depend more heavily on vulnerable overland supply routes from North Vietnam that were subject to interdiction by air and ground forces.^[21]^[6] U.S. Army assessments noted that while initial applications effectively destroyed standing crops, regrowth occurred within months absent follow-up sprays, limiting long-term denial but providing short-term tactical advantages in pacification campaigns by clearing vegetation cover and starving out embedded enemy units.^[9] This aligned with broader attrition tactics, as diminished local food production hampered sustained insurgent presence, indirectly bolstering U.S. and South Vietnamese efforts to secure population centers and expand "ink blot" controlled zones.^[9] Quantitatively, Agent Blue accounted for a significant early portion of tactical herbicide use—up to 42% prior to 1965—enhancing the overall efficacy of the herbicide program in non-defoliation roles, though its impact was most pronounced in localized denial rather than decisive strategic shifts.^[31] Military evaluations credited such operations with pressuring enemy forces to ration supplies and shift foraging patterns, which in turn facilitated intelligence gathering and ambushes, though regrowth and adaptive enemy agriculture mitigated sustained effects without repeated applications.^[9]^[35]

Environmental Impacts

Immediate Vegetation and Soil Effects

Agent Blue, containing cacodylic acid as its active ingredient, functioned as a contact desiccant herbicide, inducing rapid phytotoxic effects on vegetation, particularly grasses and rice crops. Upon foliar application, it caused wilting and desiccation by disrupting cellular metabolism and enzyme activity, with visible symptoms such as leaf burn emerging within 24 hours and severe necrosis developing over 3-4 days in affected plants.^[16] This led to the effective destruction of rice paddies, resulting in 60-90% crop loss when applied to pre-mature plants, rendering fields unproductive for immediate harvest.^[8] The herbicide's lack of systemic mobility confined damage to contacted tissues, promoting quick top-kill without deep root penetration.^[8]^[41] In soil environments, immediate effects involved the direct deposition of soluble arsenic compounds from spray drift or runoff, introducing bioavailable contaminants to the surface layer. Cacodylic acid's herbicidal activity was rapidly inactivated upon contact with moist soils, such as those in flooded rice paddies, due to adsorption and initial transformation processes that limited further phytotoxicity.^[42] However, this deposition elevated short-term arsenic concentrations, potentially affecting surface soil biota through protoplasmic poisoning, though studies indicate minimal immediate structural disruption to soil aggregates or microbial populations beyond localized toxicity.^[28] The water-soluble nature facilitated initial mobility in wet conditions, contrasting with its foliar persistence.^[43]

Long-term Arsenic Persistence

Arsenic introduced through Agent Blue applications persists indefinitely in the Vietnamese environment as the element does not degrade, with residues detectable more than 50 years after the last sprays in 1971.^[8] Approximately 1,000 tonnes of arsenic were applied, mainly to rice paddies across 400,000 hectares in the Mekong Delta, elevating baseline soil concentrations from natural levels around 5 ppm.^[44]^[8] Cacodylic acid, the primary active ingredient, undergoes microbial degradation in soils, more rapidly under the anaerobic conditions of flooded paddies, converting to mobile inorganic forms like arsenate and arsenite.^[8] These forms either bind to sediments and organic matter or leach into groundwater, where they accumulate and recirculate via extensive tube-well irrigation systems installed since 1975.^[44]^[8] Empirical studies confirm anthropogenic arsenic contributions to ongoing contamination, with groundwater concentrations in the Mekong Delta reaching up to 3,050 µg/L in sprayed areas, exceeding WHO guidelines of 10 µg/L.^[8] In rice paddy root zones, residues remain bound or are released through periodic sediment disturbances, preventing dilution despite flooding cycles.^[44] Research since 2020, including multiple analyses by Olson and colleagues, attributes a portion of the region's endemic arsenicosis to this wartime input, as levels in sediments, water, and biota show no diminishment attributable to natural half-life processes.^[44]^[8] This persistence amplifies risks in agriculture-dependent populations, with arsenic bioaccumulating in crops and aquatic species without evidence of environmental clearance.^[8]

Human Health Effects

Exposure Pathways for Military Personnel

Military personnel primarily encountered Agent Blue during its application for crop destruction in Vietnam from 1962 to 1971, with exposure routes dominated by direct handling and operational proximity. Aircraft loaders and ground crews mixing the liquid formulation (post-1964) or early powdered version faced dermal absorption from splashes, spills, and contact with equipment, alongside inhalation of vapors, mists, or dust particles generated during preparation and transfer.^[45]^[46] Inhalation risks were elevated for pilots and aircrew due to spray drift entering cockpits or helicopter cabins during low-altitude applications over rice paddies.^[47] Secondary exposures affected infantry and support units traversing treated areas, primarily through dermal contact with arsenic residues adhering to soil, vegetation, or water in flooded fields, where cacodylic acid's solubility facilitated skin penetration and potential absorption via mucous membranes.^[26] Inhalation of airborne dust from disturbed, dried-out paddies posed ongoing risks, particularly in dry seasons, while incidental ingestion occurred via contaminated hands, unwashed produce, or surface water.^[30]^[47] These pathways were compounded by the herbicide's targeted use—approximately 1.4 million U.S. gallons sprayed, often in concentrated bursts over agricultural zones—leading to localized high-exposure zones for nearby troops.^[46] Quantitative exposure modeling for tactical herbicides, including Agent Blue, estimates that application personnel received doses up to several orders of magnitude higher than ground troops, with dermal routes accounting for 50-90% of uptake depending on protective gear usage, which was inconsistent in field conditions.^[47] Cacodylic acid's rapid metabolism to dimethylarsinic acid following absorption via any route contributed to acute symptoms like gastrointestinal distress, though chronic arsenic bioaccumulation from repeated low-level contacts remains a concern in veteran health assessments.^[44]^[48] Unlike Agent Orange, Agent Blue's non-persistent phenoxy-free composition limited long-term foliar residues but enhanced soil mobility, prolonging ground-level exposure potentials.^[45]

Impacts on Vietnamese Populations

Exposure to arsenic from Agent Blue primarily affected Vietnamese civilians in the Mekong Delta, where approximately 7.8 million liters of the herbicide—containing over 1.1 million kilograms of arsenic—were sprayed between 1961 and 1971 on roughly 400,000 hectares, including 300,000 hectares of rice paddies.^[8] Cacodylic acid in Agent Blue degrades into more mobile and toxic inorganic arsenic forms, which persist in soils for decades and leach into surface and groundwater systems.^[26] This anthropogenic input compounded naturally occurring arsenic in the region's alluvial aquifers, with measured groundwater concentrations in affected areas reaching up to 3,050 µg/L, exceeding the World Health Organization's guideline of 10 µg/L by orders of magnitude.^[8] ^[44] The main exposure pathways for the estimated 15 to 20 million residents of the Mekong Delta involved chronic ingestion, with about 29% from contaminated drinking water sourced from tube wells installed since 1975 and 70% from food, particularly arsenic-accumulating rice, fish, and shrimp cultivated in sprayed zones.^[8] Inhalation occurred during burning of treated vegetation, and dermal contact via irrigation or flooding in paddies. Arsenic bioaccumulates in the food chain, with elevated levels detected in rice grains, roots, and straw from historically sprayed fields, leading to ongoing dietary intake despite the herbicide's application ceasing over 50 years ago.^[8] Health consequences mirror those of chronic inorganic arsenic poisoning, classified by the International Agency for Research on Cancer as a Group 1 human carcinogen. Documented effects include dermatological manifestations such as hyperpigmentation, hyperkeratosis, and skin cancers, alongside elevated risks for lung, bladder, kidney, and liver malignancies.^[44] ^[49] Symptoms often emerge after latent periods of years to decades, complicating attribution, but toxicological data indicate dose-dependent genotoxicity and carcinogenicity even at environmentally relevant exposures. Developmental disruptions, including low birth weight and neurotoxicity, have been associated with prenatal exposure in arsenic-endemic regions, though direct causation from Agent Blue residues requires disentangling from baseline geological contamination.^[44] Limited epidemiological studies specific to Agent Blue exist, but assessments of Mekong Delta populations show persistent arsenicosis prevalence, with the herbicide's contribution estimated to amplify risks for millions reliant on local resources.^[8]

Scientific Studies and Findings

Agent Blue, composed primarily of cacodylic acid (dimethylarsinic acid) and sodium cacodylate, exhibits moderate acute toxicity in mammalian studies, with oral LD50 values in rats varying from 64 mg/kg to 2,600 mg/kg across formulations.^[10] Dermal LD50 in rabbits exceeds 2,000 mg/kg, and inhalation LC50 in rats is 4.33 g/m³, indicating lower risk from skin contact but potential respiratory irritation at high exposures.^[10] These findings stem from controlled animal toxicology tests, which show rapid absorption via lungs (half-time of 2.2 minutes in rats) and excretion primarily through urine (75-85% in ruminants), reducing long-term accumulation compared to inorganic arsenic.^[10] Subchronic and chronic exposure studies in rodents reveal liver and kidney damage at doses above 20 mg/kg/day, alongside fetotoxicity but no consistent teratogenicity.^[10] Human case reports from occupational applicators describe mild symptoms including nausea, dermatitis, respiratory irritation, and garlic-like breath odor, attributed to arsenical metabolism, though no definitive carcinogenic link to cacodylic acid itself has been established in peer-reviewed reviews.^[10] Institute of Medicine assessments of Vietnam-era exposures conclude cacodylic acid is unlikely to be a human carcinogen, mutagen, or teratogen, distinguishing it from dioxin contaminants in other herbicides.^[50] Environmental fate research demonstrates cacodylic acid's half-life in soils ranges from 5 to 49 days under aerobic conditions, degrading microbially to arsenate, which binds to soil particles but can mobilize under reducing environments.^[51] Radiolabeled studies confirm minimal volatilization and leaching relative to parent compound, with residues showing limited phytotoxicity persistence beyond initial application.^[51] However, field applications in Vietnam, totaling approximately 1,000 tonnes of arsenic, have led to detectable groundwater contamination in the Mekong Delta, where 30-50% of sources exceed WHO's 10 µg/L limit, linked to biodegradation products and irrigation practices.^[44] Recent analyses, including eight papers since 2020 by geochemist Ken Olson, quantify arsenic persistence from Agent Blue in rice paddies and aquifers, correlating with elevated chronic exposure risks such as skin lesions, keratosis, and cancers of the lung, kidney, and bladder in local populations.^[44] These studies emphasize redox-dependent mobility, where anaerobic conditions in flooded fields enhance arsenic release, contrasting earlier views of rapid soil inactivation.^[44] Aquatic ecotoxicity tests report LC50 values around 74 mg/L for fish, with minimal biomagnification in food chains observed in controlled settings.^[10] Overall, while acute effects are well-characterized as moderate, long-term ecological and human health implications hinge on inorganic arsenic transformation products rather than the intact organoarsenic herbicide.^[10]^[44]

Controversies and Debates

Ethical Justifications and Criticisms

The use of Agent Blue, an arsenic-based herbicide containing cacodylic acid, was justified by U.S. and South Vietnamese military authorities as a targeted counterinsurgency measure to deny food resources to Viet Cong and North Vietnamese forces reliant on rice cultivation in contested rural areas.^[9] Proponents, including South Vietnamese President Ngo Dinh Diem who advocated for its initial deployment, argued that destroying standing rice crops prevented sustenance for enemy combatants embedded among civilians, thereby reducing their operational capacity without direct combat engagement.^[30] This tactic aligned with broader herbicide operations under Operation Ranch Hand, where Agent Blue's efficacy against monocotyledonous grasses like rice—desiccating foliage and halting photosynthesis—made it preferable for crop denial over incendiary methods impractical in flooded paddies.^[9] Military assessments emphasized that such denial disrupted supply chains, forcing adversaries into vulnerable foraging or resupply efforts, consistent with historical precedents in asymmetric warfare where logistical interdiction conserves friendly forces.^[31] Critics, including post-war analysts and environmental scientists, have condemned Agent Blue's deployment as ethically flawed due to its indiscriminate impact on civilian agriculture, exacerbating food shortages in South Vietnam's Mekong Delta where rice production sustained both insurgents and non-combatants.^[38] Approximately 1.2 million gallons were sprayed between 1962 and 1965, primarily on rice fields, rendering harvested lands unproductive for seasons and contributing to localized famines amid a war economy already strained by conflict.^[31] Ethical objections center on violations of proportionality and distinction under just war theory, as the herbicide's persistence—lacking biological degradation and leaching arsenic into soil and groundwater—imposed enduring harm disproportionate to tactical gains, with no evidence it decisively altered enemy resilience.^[44] Furthermore, its classification as a "secret" weapon, with limited contemporaneous oversight, raised concerns of opacity in chemical applications akin to prohibited agents, despite not breaching 1925 Geneva Protocol prohibitions on asphyxiants.^[31] Debates persist over whether food denial via toxic herbicides constitutes collective punishment, as civilian dependence on affected crops blurred combatant-noncombatant lines, potentially contravening customary international humanitarian law principles codified later in Additional Protocol I (1977).^[52] While U.S. doctrine framed it as non-lethal area denial, empirical outcomes included elevated arsenic bioaccumulation in ecosystems, prompting retrospective critiques from bodies like the National Academy of Sciences for underestimating long-term civilian welfare costs.^[46] Some military historians attribute limited strategic success to insurgents' adaptive foraging and external aid, underscoring the tactic's ethical calculus: short-term denial versus intergenerational toxicity without commensurate victory.^[53]

Legal and International Repercussions

The U.S. Department of Veterans Affairs recognizes exposure to Agent Blue as a basis for presumptive service connection for certain disabilities among Vietnam-era veterans, treating cacodylic acid within the herbicide as qualifying under herbicide exposure regulations similar to those for Agent Orange.^[54] Veterans who served in areas of Vietnam where Agent Blue was applied, or at post-war sites like Davis-Monthan Air Force Base where residues persisted until 1977, may claim benefits for conditions such as peripheral neuropathy, respiratory cancers, and soft tissue sarcomas if linked to arsenic exposure.^[55] This presumption stems from Agent Blue's classification as a tactical herbicide used for crop destruction, with over 4 million gallons sprayed between 1962 and 1971, though claims require evidence of service in sprayed regions or handling.^[56] Agent Blue featured peripherally in the major U.S. class-action litigation In re Agent Orange Product Liability Litigation (1979–1984), where Vietnamese and American plaintiffs sued chemical manufacturers for harms from multiple herbicides, including Blue's arsenic compounds deployed for defoliation and rice paddy destruction.^[57] However, unlike Agent Orange's dioxin-related settlements totaling $180 million in 1984, no dedicated payouts or manufacturer liability emerged specifically for Agent Blue, as its producer (primarily U.S. military formulations) and acute toxicity profile differed, with litigation centering on phenoxy herbicides.^[58] State-level extensions, such as Delaware's 2024 code prolonging statutes of limitations for claims involving cacodylic acid until two years post-diagnosis, reflect ongoing domestic accountability efforts but remain limited to U.S. personnel.^[59] Internationally, Agent Blue's deployment elicited no distinct legal condemnations or reparations demands separate from broader herbicidal warfare critiques during the Vietnam conflict, despite North Vietnamese protests framing U.S. spraying as chemical aggression violating the 1925 Geneva Protocol.^[60] Post-war, Vietnamese authorities pursued compensation primarily for Agent Orange's dioxin effects against firms like Monsanto, with a 2018 demand for billions in remediation, but omitted Agent Blue amid its lesser-documented transgenerational impacts and focus on soil arsenic persistence rather than immediate civilian casualties.^[61] No International Court of Justice cases or UN sanctions targeted Agent Blue specifically, as its non-lethal, anti-crop intent aligned with U.S. defenses against chemical weapon prohibitions, though a 1977 UN General Assembly resolution broadly decried herbicidal use in warfare.^[60] This relative impunity underscores Agent Blue's overshadowed status compared to dioxin-laden agents in global discourse.

Legacy and Recent Developments

Post-War Assessments

Post-war evaluations of Agent Blue's impacts have been limited compared to those for Agent Orange, with much of the focus historically on dioxin-related effects rather than arsenic persistence. Initial U.S. military and environmental reviews in the 1970s and 1980s, such as those by the National Academy of Sciences, primarily addressed tactical herbicide formulations but noted cacodylic acid's degradation into inorganic arsenic, which lacks a biological half-life and accumulates in soils and sediments.^[1] These early assessments underestimated long-term bioavailability, as arsenic from Agent Blue—estimated at 1,011 metric tons sprayed over 1964–1971—binds to iron oxides in flooded rice paddies, resisting dilution despite annual flooding in the Mekong Delta.^[44]^[8] Scientific monitoring in the 1990s and 2000s, including Vietnamese soil surveys and limited U.S.-funded analyses, detected elevated arsenic levels in former spray zones, exceeding background concentrations by factors of 2–5 in some Delta regions, correlating with reduced rice yields and uptake into food chains.^[31] A 2020 assessment attributed a portion of anthropic arsenic in Delta groundwater and surface water to wartime applications, estimating contributions of 10–20% in heavily targeted areas, though distinguishing Agent Blue from natural geogenic sources remains challenging due to overlapping signatures.^[31] These findings contrast with U.S. Department of Veterans Affairs reports, which acknowledge potential veteran exposure to cacodylic acid as a carcinogen but lack presumptive service connection akin to Agent Orange, citing insufficient epidemiological data on U.S. personnel.^[62] Recent reassessments, spurred by independent research post-2010, highlight Agent Blue's understudied toxicity, with biodegradation studies showing dimethylarsinic acid conversion to toxic arsenite under anaerobic conditions prevalent in paddies, exacerbating bioaccumulation in fish and crops consumed by Vietnamese populations.^[44] A 2021 analysis of Mekong sediments found persistent hotspots with arsenic concentrations up to 50 mg/kg, linking them to crop destruction campaigns and warning of ongoing risks to 18 million Delta residents via irrigation and dietary exposure.^[26] International bodies like the World Health Organization have not conducted dedicated Agent Blue reviews, but analogous arsenic exposure models from Bangladesh underscore causal risks of skin lesions, cancers, and neuropathy at levels observed in Vietnam.^[63] Vietnamese government claims of widespread generational harm, while amplified for reparations, align with empirical soil data but require validation against controls, as U.S. sources emphasize natural variability in arsenic baselines.^[30] Overall, these assessments reveal Agent Blue's legacy as a slow-release contaminant, with calls for expanded monitoring amid climate-driven changes in flooding patterns that could mobilize residues.^[8]

Modern Research on Residues

Modern assessments of Agent Blue residues emphasize the environmental fate of cacodylic acid, its primary active ingredient, which undergoes microbial degradation in soil to form dimethylarsinic acid, monomethylarsonic acid, and ultimately inorganic arsenic species such as arsenite (As(III)) and arsenate (As(V)).^[32] This process occurs relatively rapidly under aerobic conditions, with half-lives reported on the order of days to weeks, though slower under anaerobic wetland environments common in rice paddies.^[8] The resulting inorganic arsenic binds strongly to soil particles, particularly iron oxides and clays prevalent in Vietnamese soils, limiting its mobility and bioavailability.^[64] Despite the application of approximately 1.1 million gallons of Agent Blue, delivering over 1,000 metric tons of arsenic primarily to the Mekong Delta between 1962 and 1971, direct measurements of attributable residues remain scarce in contemporary field studies.^[44] Total soil arsenic concentrations in former spray zones often exceed background levels but are confounded by natural geogenic sources in the region's alluvial sediments, making isolation of war-related contributions challenging without isotopic or historical tracing.^[65] Groundwater arsenic in southern Vietnam, while elevated in some areas (up to 50–100 μg/L in hotspots), is predominantly linked to reductive dissolution of iron-bound arsenate in aquifers rather than direct herbicide leaching, with Agent Blue's influence estimated as a minor additive factor.^[65] A 2025 review highlights the relative understudy of Agent Blue compared to dioxin-focused research on Agent Orange, attributing this to the perceived lower persistence of organic arsenicals and the complexity of distinguishing anthropogenic from natural arsenic cycles.^[44] Experimental soil simulations indicate that bound arsenate exhibits low phytoavailability, with rice uptake reduced by soil amendments like phosphorus fertilizers, though chronic low-level exposure via food chains persists as a concern in unremediated paddies.^[33] Ongoing monitoring by Vietnamese authorities, integrated with broader heavy metal assessments, reports no widespread exceedance of arsenic thresholds in agricultural soils attributable solely to wartime spraying, but calls for targeted remediation in high-use rice areas.^[35]

References

[1]
Exposure to the Herbicides Used in Vietnam - NCBI - NIH
Agent Blue was used in powder form in 1962–1964 and as a liquid in 1964–1971. Agent Pink, Agent Green, Agent Purple, Agent Orange, and Agent Orange II all ...
[2]
Agent Orange During the Vietnam War: The Lingering Issue of Its ...
May 9, 2018 · Agent Blue, which consisted of dimethylarsinic acid (salt of cacodylic acid), was used primarily for crop destruction. Agent White was a mixture ...Missing: historical | Show results with:historical
[3]
SELECTED CHEMICALS USED DURING THE VIETNAM WAR - NCBI
Agent Blue was effective against grasses and grains, such as rice (Young, 2009). Herbicide Composition. 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) was the main ...
[4]
3 The U.S. Military and the Herbicide Program in Vietnam
Agent Orange, a 1:1 mixture of 2,4-D and the n-butyl ester of 2,4,5-T, accounted for approximately 61 percent of the recorded herbicide use. Orange was the ...
[5]
[PDF] The extent and patterns of usage of Agent Orange and other ...
Herbicides including Agent Orange were sprayed by United States forces for military purposes during the Vietnam War (1961–.
[6]
[PDF] The Effects of Herbicides in South Vietnam, Part A
Jan 5, 2001 · herbicide agents used in the Vietnam war and the application rates are ... noting that almost twice as much Agent Orange as Agent Blue was used on.
[7]
[PDF] The Persistent Health Effects of Defoliating Vietnam
Nov 16, 2023 · Abstract. This study investigates the long-run unintended environmental effects of con- flicts on health and socioeconomic outcomes by ...
[8]
The Fate of Agent Blue, the Arsenic Based Herbicide, Used in South ...
From 1961 to 1971 Agent Blue was used by the South Vietnamese and American military to kill rice, bamboo and banana vegetation in South Vietnam [35]. Arsenic ...
[9]
The U.S. Military and the Herbicide Program in Vietnam - NCBI - NIH
More than 90 percent (93.9 percent) of the women in the study were white. ... Blue was the code designation for a liquid formulation of cacodylic acid and its ...
[10]
[PDF] Cacodylic Acid - National Agricultural Library
Feb 22, 2002 · ... Agent Blue, containing 26.4% NaCA and 4.7% CA. Phytoplankton: Microscopic aquatic plant life. Phytotoxic: Toxic (harmful) to plants. 160 ...
[11]
[PDF] Untitled - Foundation for Worker, Veteran, and Environmental Health
... Agent Blue was changed to a liq- uid formulation of cacodylic acid, thereby eliminating the need for mixing operations. Agent Orange replaced all formula-.<|separator|>
[12]
[PDF] Commercial and Tactical Herbicides used in Vietnam and Thailand ...
Apr 25, 2025 · The tactical herbicide Agent Blue contained 370 g ai per L cacodylic acid/sodium cacodylate. It was not diluted before spraying [10, 11]. RANCH ...
[13]
Cacodylic acid - AERU - University of Hertfordshire
Cacodylic is an obsolete arsenical herbicide. It is highly soluble in water. Very little else is known about the environmental fate of cacodylic acid nor ...Missing: composition percentage<|control11|><|separator|>
[14]
[PDF] Cacodylic Acid | Prevent Cancer Now
Cacodylic acid, which is also known as dimethylarsinic acid, is an arsenical non-selective contact herbicide which defoliates or desiccates a wide variety of ...
[15]
Use Of Herbicides Around Your Trees | Arboriculture & Urban Forestry
The first two, Paraquat and cacodylic acid are not translocated within the plant. They will kill most green tissue on contact. The Paraquat is the only one of ...
[16]
[PDF] Comparative Phytotoxicity Among Four Arsenical Herbicides'
Hence, one concludes that cacodylic acid is a more effective inhibitor of biological processes critical to plant growth. Cacodylic acid and MSMA were much less ...
[17]
[PDF] Arsenical Pesticides - EPA
Two biochemical mechanisms of toxicity are recognized: (1) reversible combination with thiol groups contained in tissue proteins and enzymes and (2) ...
[18]
Arsenic Toxicity: The Effects on Plant Metabolism - Frontiers
Arsenic exposure generally induces the production of reactive oxygen species that can lead to the production of antioxidant metabolites.
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[PDF] The history of arsenical pesticides and health risks related to the use ...
The term 'Agent Blue' was first applied to cacodylic acid in powder form that was mixed with water in the field. Cacodylic acid is a highly-soluble organic ...
[20]
2 Background | Veterans and Agent Orange: Update 11 (2018)
All agents were liquid except Agent Blue, which was used in powder form in 1962–1964 and as a liquid in 1964–1971. Agent Pink, Agent Green, Agent Purple, Agent ...Missing: facts | Show results with:facts<|control11|><|separator|>
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Agent Blue Spraying in the Mekong Delta during the Vietnam War
Agent Blue, a mixture of cacodylic acid (CH3) As O2H) and sodium cacodylate (C2H6 AsNaO2), was a tactical arsenic-based herbicide used during the Vietnam War to ...
[22]
CACODYLIC ACID - CAMEO Chemicals - NOAA
A colorless, odorless crystalline solid. Melting point 195-196°C. Toxic by ingestion and irritating to skin and eyes.
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https://www.fishersci.com/store/msds?partNumber=AC318150050
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The history of arsenical pesticides and health risks related to the use ...
Jun 12, 2017 · Arsenical herbicides containing cacodylic acid as an active ingredient have been used extensively in the USA, from golf courses to cotton fields, and drying- ...<|separator|>
[25]
How United States Agricultural Herbicides Became Military and ...
Agent Blue, with its active ingredient cacodylic acid, was a dual purpose herbicide developed during WWII, could also have been transferred to USDA, Forest ...
[26]
The Fate of Agent Blue, the Arsenic Based Herbicide, Used in South ...
Agent Blue (cacodylic acid, C2H2AsO2,) was the most effective of all the Rainbow herbicides in killing rice and grasses.
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"Cacodylic Acid as a Silvicide" by Maurice W. Day
Day, Maurice W. 1965. Cacodylic Acid as a Silvicide. Michigan Agricultural Experiment Station, Michigan State University, East Lansing.
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Initial Scientific Review of Cacodylic Acid - epa nepis
When cacodylic acid was given by drench at 50 mg/kg, toxic signs appeared after the first dose and death after the seventh. Sheep treated for 10 days at 50 mg/ ...
[29]
[PDF] Agent Blue: A Secret Military and Environmental Chemical Weapon ...
Mar 10, 2023 · The. Agent Blue precursor reagent, cacodylic acid, was invented at Fort Detrick in. 1957. 2.3. Agent Blue, the Arsenic Based Herbicide, ...
[30]
Agent Blue - The VVA Veteran
Many military personnel used hand sprayers. Agent Blue, in particular, was often sprayed by hand to kill bamboo. And spraying was done from the backs of trucks.
[31]
Agent Blue: A Secret Military and Environmental Chemical Weapon ...
Agent Blue, the arsenic-based herbicide, became a secret US military and environmental chemical weapon used by the RV and US militaries in southern Vietnam
[32]
Agent Blue Spraying in the Mekong Delta during the Vietnam War
Aug 9, 2025 · Vietnam War veterans, historians and scholars have reported the spraying of 3.2 million liters (468,008 kg As) of Agent Blue on rice paddies and ...
[33]
Review and Analysis: Agent Blue, the Arsenic Based Herbicide ...
Agent Blue, a mixture of cacodylic acid (C2H7AsO2) and sodium cacodylate (C2H6AsNaO2), was a tactical arsenic-based herbicide used during the Vietnam War to ...
[34]
[PDF] Typescript: Chapter 2: The Military Use of Herbicides in Vietnam ...
Jan 5, 2001 · The introduction of herbicides in 1962 into the armed conflict in. Vietnam represented an application of a new technique for modern warfare.Missing: invention date
[35]
Review and Analysis: Agent Blue, the Arsenic Based Herbicide ...
Aug 4, 2025 · Effects of Herbicides. and Humans”. Human reactions to US and South Vietnam military spraying of. Agent Blue herbicide was included in studies ...<|separator|>
[36]
AO OP Ranch Hand - 2-12th Infantry Regiment "Warriors"
The herbicide used for crop denial missions was Agent Blue, a sodium salt of cacodylic acid. Proposed targets were carefully screened at all echelons. Agent ...
[37]
Agent Blue Haunts Vietnam War Vets - TRANSCEND International
Dec 21, 2020 · “Agent Blue was sprayed on 100,000 hectares (one hectare is about 2.5 acres) of mangrove forests and about 300,000 hectares of rice paddies just ...
[38]
(PDF) Agent Blue: A Secret Military and Environmental Chemical ...
Aug 9, 2025 · Agent Blue: A Secret Military and Environmental Chemical Weapon Used for Food Denial in South Vietnam during the Vietnam Civil War (1962-1965).
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The Assessment of Exposure to Herbicides Among Vietnam Veterans
Ground spraying, although probably representing a smaller quantity of herbicide than aerial spraying, may actually have resulted in heavier human exposures ...
[40]
'Agent Blue' in Vietnam - The New York Times
Jul 12, 1971 · The United States has been destroy ing growing crops in South Vietnam since at least November 1961 as part of its “resource denial” program.Missing: deployment | Show results with:deployment
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Our Chemical War | Seymour M. Hersh
Crafts, a University of California agronomist, notes that “cacodylic acid gives a very rapid top [plant] kill….” Crafts said in a subsequent interview that ...
[42]
Update on Cacodylic Acid, The Major Component of Agent Blue
Agent Blue was an organic arsenical as cacodylic acid and sodium cacodylate, and once in contract with the soil it would have been bound within the soil matrix ...Missing: composition | Show results with:composition
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Health and Environmental Effects Document for Cacodylic Acid
In aerobic soils, cacodyllc add will undergo blodegradatlon ,w1th the formation of primarily arsenate. The blodegradatlon rate may depend on the nature of soil, ...
[44]
The toxic legacy of Agent Blue | Research - Chemistry World
Jan 8, 2025 · Agent Orange's use during the Vietnam War is well known. But the use of another herbicide during the war, known as Agent Blue, has remained largely unexplored.
[45]
Exposure to the Herbicides Used in Vietnam - NCBI - NIH
Herbicides were identified by the color of a band on 55-gal containers and were called Agents Pink, Green, Purple, Orange, White, and Blue. Agent Green and ...<|control11|><|separator|>
[46]
Chapter: 3 Exposure to the Herbicides Used in Vietnam
Agent Blue (powder and liquid) contained cacodylic acid. The chlorinated phenoxy acids 2,4-D and 2,4,5-T persist in soil for only a few weeks; picloram is much ...<|separator|>
[47]
EXPOSURE ROUTES AND MECHANISMS - Blue Water Navy ...
In the sections below, the committee examines the environmental pathways that could result in exposure of ground troops, Brown Water Navy personnel, and Blue ...
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Three Primary Cancers in a Veteran With Agent Orange ... - MDEdge
Aug 18, 2021 · Our patient's history is concerning for higher than average Agent Blue exposure compared with that of most Vietnam War veterans. Given the dose- ...
[49]
https://www.atsdr.cdc.gov/substances/toxsubstance.asp?toxid=3
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Fate of Arsenic Applied to Canal Shipping Lane Vegetation and ...
Reviews of the limited available studies by the Institute of Medicine concluded that cacodylic acid was likely not a carcinogen, teratogen, or a mutagen in man.Missing: persistence | Show results with:persistence
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Persistence and reactions of [14C]-cacodylic acid in soils
Arsenic biotransformation and mobilization: the role of bacterial strains and other environmental variables. Environmental Science and Pollution Research ...
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Why isn't the use of Agent Orange in Vietnam by the United States ...
Jul 17, 2019 · Using Agent Orange as a defoliant wasn't a war crime. Defoliation wasn't a war crime. But we can debate whether or not these things were moral, ...
[53]
What is your opinion on Agent Orange and other chemicals used by ...
Feb 25, 2023 · Well, clearly not, since they lost the Vietnam War. Herbicide use, to destroy crops and ground cover, induce widespread famine, and thereby ...
[54]
9626460.txt - VA.gov
Agent Blue is an herbicide containing cacodylic acid, and is therefore an herbicide agent for purposes of presumptive service connection. The veteran's service ...<|control11|><|separator|>
[55]
Exposure to Agent Blue at Davis-Monthan Air Force Base - CCK Law
Apr 4, 2018 · Veterans who served at Davis-Monthan Air Force Base between 1973 and 1977 may have been exposed to the toxis herbicide Agent Blue.Missing: soldiers | Show results with:soldiers
[56]
Updating VA Adjudication Regulations for Disability or Death Benefit ...
Feb 12, 2024 · The Department of Veterans Affairs (VA) proposes to amend its adjudication regulations relating to exposure to certain herbicide agents.
[57]
In Re Agent Orange Product Liability Litigation, 597 F. Supp. 740 ...
Various herbicides were used for defoliation and crop destruction spraying in Vietnam including Agent Blue ... effects of herbicide spraying in Vietnam.
[58]
Vietnam veterans exposed to Agent Orange win $180 million ...
May 6, 2024 · Agent Orange was a chemical herbicide used during the Vietnam War that had a devastating impact long after the conflict ended. 2:29m watch.Missing: repercussions | Show results with:repercussions
[59]
Limitation for Indochina herbicide exposure. :: 2024 Delaware Code ...
... Agent Orange, Agent Blue, Agent White and chemical components known as 2, 4-D; 2, 4, 5-T; TCDD; Picloran and cacodylic acid, shall not expire until 2 years ...
[60]
History of the Controversy Over the Use of Herbicides - NCBI
... military use of herbicides in Vietnam during the Vietnam era. The ... Agent Orange and other herbicide use in Vietnam. Several groups developed ...<|separator|>
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Vietnam Demands Compensation from Monsanto for Devastating ...
Sep 4, 2018 · ... case may be sparking bolder actions on the toxic weed killer. ... herbicide Agent Orange on contaminated aircraft used after the Vietnam War.<|separator|>
[62]
Have You Heard of VA Disability Claims for Agent Blue?
Nov 15, 2017 · Agent Blue is an arsenical herbicide used in Vietnam, containing cacodylic acid. It was used to destroy broadleaf plants and trees, especially ...
[63]
Agent Blue haunts Vietnam War vets - Asia Times
Dec 7, 2020 · Agent Blue, an arsenic-based herbicide, is becoming known because it has no half-life – in other words, it lasts forever in soil, sediments ...
[64]
Environmental and Human Health Impacts of Herbicide Use Studies ...
Aug 4, 2025 · By 1970, the Department of Defense (DoD) was ordered to permit the scientists to visit South Vietnam during the war to document these impacts.
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[PDF] Arsenic Contamination in Groundwater in Vietnam
This means that 4.8% of Agent. Blue is an arsenical with similar properties to arsenate. This also means it reacts and bioaccumulates just like arsenate. Figure ...