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Aleph Farms

Aleph Farms is an Israeli cellular agriculture company that develops cultivated beef products, such as steaks, by growing bovine cells in bioreactors to replicate animal tissues without raising or slaughtering livestock.^[1]
Founded in 2017 by Didier Toubia, Shulamit Levenberg, and Neta Lavon and headquartered in Rehovot, the firm focuses on non-genetically modified cells to produce high-quality meat alternatives aimed at enhancing food security, reducing environmental impacts of farming, and improving animal welfare.^[2]^[3]^[1]
Key achievements include unveiling the world's first cultivated thin-cut steak in 2018 and the first cultivated ribeye using 3D bioprinting, followed by securing the world's initial regulatory approval for non-chicken cultivated meat from Israel's Ministry of Health in 2024, enabling limited commercial sales.^[4]^[5]^[6]
The company has raised over $140 million in funding, including a $105 million Series B round backed by investors like Cargill and Migros, but has encountered substantial hurdles, such as a 30% workforce reduction in 2024 and a 73% valuation cut in ongoing financing efforts amid investor skepticism toward cultivated meat's path to cost-competitive scalability.^[7]^[8]^[9]^[10]
Independent techno-economic analyses project potential profitability for its products at scale, with production costs reduced by 97% since 2022, though broader industry challenges like bioreactor efficiency and market acceptance persist.^[11]^[8]

Founding and Early Development

Inception and Founders

Aleph Farms originated from pioneering research in cellular agriculture conducted at the Technion – Israel Institute of Technology. In 2016, Professor Shulamit Levenberg of the Faculty of Biomedical Engineering initiated experiments growing bovine cells on a plant-based protein matrix scaffold, aiming to replicate tissue formation outside an animal's body.^[1] This foundational work laid the groundwork for cultivated meat production, focusing on assembling muscle, fat, and connective tissues to form structured beef products. The company was formally co-founded in 2017 by Levenberg, entrepreneur Didier Toubia, and stem cell biotechnologist Dr. Neta Lavon, in partnership with The Kitchen, a food-tech incubator operated by the Strauss Group.^[1] ^[2] Toubia, a French-Israeli serial entrepreneur with prior experience leading medical device firms like IceCure Medical (which went public in 2010) and NLT Spine (acquired by SeaSpine in 2016), served as CEO and drove the commercial vision.^[1] Levenberg, holding a professorship in biomedical engineering at the Technion, contributed expertise in tissue engineering and scaffolds, while maintaining her role as chief scientific adviser.^[12] Lavon, with over 20 years in stem cell applications including roles in regenerative medicine, became chief technology officer, specializing in cell proliferation and differentiation protocols essential for scalable cultivation. The inception emphasized adapting academic tissue engineering principles—such as 3D bioprinting and bioreactor optimization—to food production, with early efforts centered in Rehovot, Israel.^[13]

Initial Milestones and Funding Rounds

Aleph Farms was established in 2017 in Rehovot, Israel, by co-founders Didier Toubia, Aharon Fleury, and Professor Shulamit Levenberg of the Technion – Israel Institute of Technology, in partnership with The Kitchen Food Tech Hub, an incubator of the Strauss Group.^[14]^[15] In December 2018, the company achieved an early milestone by producing the world's first cultivated thin-cut steak using bovine cells, demonstrated in a bioreactor on the International Space Station in collaboration with Russian firm 3D Bioprinting Solutions to test microgravity effects on cell growth.^[4]^[13] The firm's initial funding came via a Series A round closed on May 14, 2019, raising $12 million (approximately €10.7 million), led by Singapore-based VisVires New Protein with participation from Peregrine Ventures, Strauss Group, and other investors; proceeds supported scaling manufacturing processes for commercial thin-cut steaks targeted for market entry within two years.^[13]^[16] This was followed by a substantially larger Series B round of $105 million announced on July 7, 2021, backed by investors including Cargill, Tyson Foods, and Migros Industrie, aimed at expanding production facilities, international operations, and preparations for regulatory approvals ahead of a planned 2022 launch.^[17]^[14] By mid-2025, Aleph Farms had secured over $140 million in total funding across multiple rounds since inception, though early-stage investments prior to Series A remain undisclosed in public records.^[18]

Technological Approach

Core Cultivation Process

Aleph Farms' core cultivation process begins with the establishment of cell lines derived from a fertilized egg obtained from a Black Angus cow named Lucy, sourced once from a premium California herd. These cells, primarily muscle and collagen-producing types responsible for tissue regeneration, are extracted after brief embryonic development and cryopreserved in a cell bank at sub-zero temperatures to enable scalable production without repeated animal interventions.^[19]^[20] The selected starter cells are then transferred to bioreactors—temperature-controlled, sterile, closed-system vessels mimicking the cow's natural regenerative environment. Here, cells proliferate through duplication, guided by an animal-free growth medium comprising water, oxygen, carbohydrates, fats, amino acids, vitamins, minerals, and non-animal-derived growth factors produced via plant sources or microbial fermentation; this formulation avoids fetal bovine serum and genetic modifications to the cells.^[19]^[20]^[21] The process induces differentiation into specific tissue types, including skeletal muscle, fat, and connective tissues, over approximately three to four weeks, during which cells expand and mature to form the foundational biomass for structured meat products.^[19]^[21] This cultivation adheres to tissue engineering principles, replicating in vivo muscle fiber formation without slaughter, though it relies on proprietary media optimization to achieve viability at scale; empirical validation of efficiency remains tied to company-reported benchmarks rather than independent large-scale trials.^[20]^[22] Recent modifications to the process, including AI-assisted bioprocessing, aim to reduce steps and costs while maintaining cell yield, but detailed proliferation rates and medium composition specifics are not publicly disclosed beyond general descriptions.^[23]^[24]

Innovations in Bioprinting and Optimization

Aleph Farms employs 3D bioprinting to construct cultivated beef steaks by layering living bovine cells—primarily muscle and fat—into a bio-ink formulation, which is then printed and incubated to form structured tissue mimicking natural muscle architecture.^[22] This approach utilizes a pea protein-based scaffold in place of animal-derived extracellular matrices, enabling sustainable production while supporting cell proliferation and differentiation.^[22] A key innovation is the integration of a proprietary vascular-like network within the printed structure, allowing for thicker cuts beyond the diffusion-limited thickness of conventional cell cultures, as demonstrated in the company's February 2021 unveiling of the world's first cultivated ribeye steak.^[22] Marbling is achieved by precisely controlling the ratio of fat cells in the bio-ink, replicating intramuscular fat distribution observed in traditional beef.^[22] These techniques were detailed in a peer-reviewed study published in Biomaterials in 2022, co-authored by Aleph Farms researchers and collaborators from the Technion-Israel Institute of Technology.^[22] To optimize production efficiency and scalability, Aleph Farms introduced a revised "1.2" process in March 2025, which consolidates cell proliferation and differentiation into a single stirred-tank bioreactor step, eliminating a prior secondary bioreactor and reducing differentiation time by 60%.^[23] This modification incorporates cells directly into a plant protein matrix post-printing, facilitating thicker steak formation and improved yield at larger scales, contributing to a 97% reduction in unit production costs since 2020—reaching $14 per pound at 2,000–5,000-liter bioreactor volumes and projected at $6–7 per pound for commercial facilities.^[23] The company secured $29 million in funding in early 2025 to commercialize this technology, emphasizing non-genetically modified, non-immortalized cells to align with regulatory and consumer preferences.^[23] Further enhancements involve an AI partnership with BioRaptor, announced in 2024, deploying an AI operating system to analyze real-time data from bioreactors—tracking variables such as pH, dissolved oxygen, and temperature—via design-of-experiments methodologies.^[24] This integration aims to refine process parameters, minimize experimental variability, and de-risk scale-up to mid- and large-scale facilities without excessive upfront capital.^[24] An independent techno-economic analysis by Eridia, conducted for 5,000-liter bioreactors, projects unit costs of $6.45 per pound for cultivated steaks, yielding a 47% gross margin at wholesale price parity with conventional beef ($12.25 per pound), with potential further reductions to $4.08 per pound through ongoing optimizations and a 2.5-year payback period for facilities in Asia and Europe.^[11]

Products and Production

Key Product Developments

In December 2018, Aleph Farms produced the world's first cultivated thin-cut steak from bovine cells, demonstrating initial capabilities in structured meat cultivation without animal slaughter.^[25] This milestone involved mimicking natural muscle regeneration processes over approximately 3–4 weeks in bioreactors.^[21] Advancing toward thicker, more complex cuts, Aleph Farms collaborated with the Technion-Israel Institute of Technology to unveil the world's first cultivated ribeye steak in February 2021. This product utilized 3D bioprinting to assemble layers of real bovine muscle and fat cells—sourced from non-genetically modified, non-immortalized Black Angus cow cells—along with a proprietary vascular-like network for nutrient perfusion, enabling organoleptic properties akin to conventional ribeye while supporting scalability for fattier steaks.^[26]^[27] In April 2023, the company launched the Aleph Cuts brand, introducing the Petit Steak as its first commercial prototype—a hybrid cultivated beef product blending cultivated cells with plant-based proteins for texture and nutrition, produced antibiotic-free over about four weeks.^[28]^[19] This steak, derived from unmodified Black Angus cells, received Israel's regulatory approval for human consumption in December 2023, the first such authorization globally for cultivated beef and non-chicken cultivated meat.^[5]^[29] Aleph Farms has also pursued a "whole animal" approach by developing cultivated collagen from living bovine cells, announced in 2023, to replicate connective tissues and enable diverse cuts without relying on slaughter-derived materials.^[30] In March 2025, refinements to its bioprinting and cultivation processes reduced steps for whole-cut production, targeting lower costs estimated at $6.45 per pound for steak manufacturing.^[23]^[31]

Scaling and Cost Dynamics

Aleph Farms has achieved significant cost reductions in cultivated meat production, reporting a 97% decrease since 2020 through process tweaks that eliminate expensive steps, such as certain scaffolding and media components, while maintaining whole-cut steak integrity.^[23] In March 2025, the company secured $29 million in funding to advance commercialization of this optimized technology, targeting production costs of $14 per pound at bioreactor volumes of 2,000 to 5,000 liters.^[23] An independent techno-economic analysis released in September 2025 projects further scalability, estimating unit production costs for cultivated beef steaks at $6.45 per pound upon full optimization, against a wholesale price of $12.25 per pound, yielding a 47% gross margin and annual net profits of $78.5 million at commercial scale.^[11] ^[32] These projections assume advancements in cell proliferation efficiency and supply chain integrations, with raw materials—primarily growth media—comprising the bulk of cost of goods sold.^[32] To address scaling hurdles, Aleph Farms employs AI-driven process modeling via a May 2024 partnership with BioRaptor, enhancing bioreactor yield and media utilization for capital-efficient expansion beyond pilot stages.^[33] Additional strategies include animal-free growth factors and strategic supplier agreements to minimize media expenses, which historically dominate 50-80% of total costs depending on product type and scale.^[34] ^[35] Challenges persist in bioreactor scaling, including high upfront capital for large-volume vessels and the complexity of maintaining cell differentiation without microcarriers, which can inflate costs if not optimized.^[36] Industry-wide, cultivated meat production costs have fallen from over $2 million per kilogram in early demonstrations to around $63 per kilogram as of mid-2025, but achieving parity with conventional beef—targeting under $3 per pound—requires sustained innovation in perfusion systems and media recycling.^[36] Aleph Farms acknowledges that while lab-to-pilot transitions are underway, full commercial viability hinges on these unresolved efficiencies.^[37]

Sustainability and Environmental Claims

Asserted Benefits

Aleph Farms asserts that its cultivated beef products offer substantial environmental advantages over conventional beef production, primarily through reduced resource intensity and emissions when scaled with renewable energy sources. According to a life cycle assessment (LCA) commissioned by the company and conducted by CE Delft, cultivated beef achieves a 92% lower greenhouse gas (GHG) emissions footprint compared to intensive Western European beef farming.^[38] ^[39] The process is claimed to yield a 90% reduction in land use and a 66% decrease in water consumption relative to traditional methods, addressing pressures on arable land and freshwater resources.^[38] Additionally, the technology is said to result in a 94% lower pollution burden, stemming from minimized manure and fertilizer runoff associated with livestock rearing.^[38] The company's production model further emphasizes efficiency by deriving vast quantities of meat from a single fertilized bovine egg, potentially eliminating the need for large-scale animal husbandry and its attendant environmental externalities like deforestation and habitat disruption.^[38] Aleph Farms claims a 5.5-fold improvement in feed conversion ratio over conventional beef (excluding grass-fed systems), optimizing nutrient inputs without reliance on expansive grazing lands.^[38] These benefits are positioned as contributions to broader sustainability goals, including mitigation of climate change, water scarcity, and biodiversity loss, by decoupling protein production from ecologically taxing animal agriculture.^[40] To operationalize these advantages, Aleph Farms committed in 2020 to achieving net zero carbon emissions in its direct operations (Scopes 1 and 2) by 2025 and across the full supply chain (including Scope 3) by 2030, marking it as the first cultivated meat firm to set such targets.^[39] ^[40] The roadmap involves energy optimization, renewable sourcing, and emissions offsetting or insetting, supported by partnerships like ENGIE Impact for footprint measurement and reduction strategies.^[39] Complementary initiatives include waste management programs that recycle seven waste streams into energy, thereby curbing landfill methane contributions.^[38] These measures are framed as enabling a transition to resilient food systems with lower ecological demands.^[40]

Empirical Critiques and Data Gaps

While Aleph Farms asserts environmental benefits through internal life cycle assessments (LCAs) of its cultivated bovine products, including reduced greenhouse gas (GHG) emissions compared to conventional beef, these claims rely on projections rather than data from commercial-scale operations.^[38] Independent analyses of cultivated meat processes, applicable to Aleph's bioreactor-based approach, highlight high energy intensity as a primary concern; for instance, maintaining sterile conditions, cell proliferation, and tissue maturation requires substantial electricity for temperature control, agitation, and purification, potentially exceeding beef production's footprint if grid electricity is used without near-100% renewables.^[41] A 2023 cradle-to-gate LCA modeled cultivated meat's GHG emissions as up to 25 times higher than beef under realistic near-term scenarios involving crop-derived glucose media and conventional energy sources. Critiques extend to water usage and eutrophication, where purified media production and wastewater treatment in bioreactors could amplify impacts beyond initial estimates, as early LCAs often undervalue downstream processing demands.^[42] Aleph's commitment to net-zero corporate emissions by 2025 focuses on operational footprints but does not address product-specific externalities like supply chain inputs, which peer-reviewed reviews identify as overlooked in industry projections.^[43] ^[44] For example, nutrient media sourced from agricultural glucose or amino acids may indirectly require land and water comparable to or exceeding pasture-raised systems, challenging claims of drastic reductions without verified low-impact alternatives. Significant data gaps persist due to the pre-commercial status of Aleph's products; ex-ante LCAs, including those incorporating Aleph's pilot data, extrapolate from lab-scale efficiencies that degrade at scale due to contamination risks, lower cell densities, and increased purification needs.^[45] ^[46] No peer-reviewed, full-scale LCAs exist for Aleph's cultivated steak process, limiting verification of asserted benefits like 92% GHG reductions, which assume optimistic technological breakthroughs in media recycling and renewable integration not yet demonstrated.^[47] These gaps are compounded by variable assumptions across studies, such as energy recovery rates and media purity, leading to sustainability claims deemed overly ambitious and unsupported by empirical evidence from operational facilities.^[48] ^[42] Long-term data on bioreactor durability, microbial stability, and holistic impacts—including novel waste streams from cell scaffolding—are absent, hindering causal assessments of net environmental realism.^[44]

Regulatory and Commercial Progress

Approvals and Market Strategies

In January 2024, Israel's Ministry of Health granted Aleph Farms the world's first regulatory approval for cultivated beef, deeming its cell-cultured Black Angus Petit Steak safe for human consumption after safety evaluations.^[49]^[5] This approval marked the third global authorization for any cultivated meat product, following prior chicken approvals in Singapore and the United States, but the first for beef.^[50] As of September 2025, full commercialization in Israel remained pending final Good Manufacturing Practices (GMP) certification, with plans for a launch within six months.^[51]^[52] Aleph Farms also secured kosher certification for its cultivated beef in January 2023 from Israel's Chief Rabbi, facilitating potential acceptance in religious markets.^[53] Internationally, the company submitted Europe's first cultivated meat application to Switzerland's Federal Food Safety and Veterinary Office in July 2023, followed by Thailand's inaugural filing in December 2024 in partnership with Thai Union, targeting mid-2026 clearance.^[54]^[55]^[56] Aleph Farms pursues an asset-light commercialization model, emphasizing third-party manufacturing collaborations to minimize capital expenditure and leverage existing facilities for scaling.^[52] The strategy prioritizes Asia for initial market entry due to regulatory openness and demand, alongside Europe via a planned Swiss production facility announced in September 2025 to support regional launches.^[57]^[58] In 2024, it secured four commercial agreements—two in Asia, one in Israel, and one in Europe—to accelerate distribution.^[23] Cost reductions, achieving a 97% drop in production expenses since 2020, underpin this approach, supported by partnerships like a long-term supply chain deal with Thermo Fisher Scientific for growth media.^[23]^[59] A three-phase rollout focuses first on foundational scaling, followed by product commercialization and broader ecosystem integration.^[51]

Expansion Plans and Partnerships

Aleph Farms has pursued international expansion through strategic facility developments and co-production agreements to scale cultivated meat production beyond Israel. In February 2024, the company partnered with BBGI, a bio-based products manufacturer, and Fermbox Bio, a synthetic biology firm, to establish a large-scale cultivated meat facility in Thailand, marking Southeast Asia's first such site aimed at cost reduction and regional scalability.^[60]^[61] By September 2025, Aleph Farms signed a memorandum of understanding with The Cultured Hub to develop its inaugural European production facility in Kemptthal, Switzerland, focusing on long-term manufacturing partnerships compliant with regional standards.^[31] In Asia, the firm secured a co-production deal with ESCO Aster in Singapore and advanced construction of a Thai factory to support broader distribution.^[58] Domestically, Aleph Farms expanded operations in Israel by acquiring a manufacturing facility in Modi'in from VBL Therapeutics and integrating related assets to bolster pilot-scale production.^[62] The company relocated to a 65,000-square-foot facility incorporating a pilot plant, R&D center, and community space to facilitate commercialization.^[63] In 2024, Aleph Farms executed four commercial agreements—two in Asia, one in Israel, and one in Europe—to accelerate market entry, supported by a $29 million funding round in March 2025 targeted at technology modifications for cost efficiency.^[64] Key partnerships include a collaboration with Brazilian protein giant BRF announced in 2023 to co-develop and produce cultivated meat using Aleph's BioFarm platform, adapting it for local supply chains.^[65] Additional alliances encompass Thai Union for Southeast Asian processing and Mitsubishi in Japan for distribution, reflecting a manufacturing-partner model to navigate regulatory variances.^[52] Earlier investments, such as Cargill's 2019 stake, have informed scaling strategies, though recent efforts emphasize regional co-productions over equity ties.^[66] Aleph Farms anticipates UAE market entry pending regulatory alignment, leveraging these partnerships for initial launches.^[51]

Space Initiatives

Aleph Zero Program Overview

The Aleph Zero Program, announced by Aleph Farms on October 21, 2020, represents the company's initiative to develop cultivated meat production capabilities in microgravity environments, beginning with the International Space Station (ISS). Named after the mathematical symbol ℵ₀ denoting the smallest infinite cardinal number, the program symbolizes efforts to enable sustainable, resource-independent food systems for space exploration and extreme terrestrial conditions. Its primary purpose is to create self-sustaining technologies for growing fresh, high-quality animal-derived proteins—such as steaks—without reliance on traditional agriculture, thereby addressing nutritional needs for astronauts on long-duration missions and enhancing global food security amid climate variability and resource scarcity.^[67]^[68]^[69] Central to the program are advancements in cellular agriculture adapted for space, including 3D bioprinting and bioreactor systems that mimic bovine muscle tissue regeneration under microgravity. These technologies aim to overcome challenges like altered cell proliferation and differentiation in low-gravity conditions, potentially reducing dependency on resupply chains for perishable foods during extended space travel. By fostering local production of cultivated meat, Aleph Zero seeks to minimize environmental footprints associated with conventional meat farming, such as land and water use, while providing a model for resilient food systems on Earth in arid or crisis-prone regions. The initiative aligns with broader goals of enabling multiplanetary human expansion, as articulated by company leadership, though empirical validation remains tied to ongoing experimentation rather than commercial deployment.^[68]^[70]^[38] Key milestones include the program's foundational experiment in September 2019, where Aleph Farms, in partnership with Russia's 3D Bioprinting Solutions, successfully cultivated the first slaughter-free meat aboard the ISS using a 3D bioprinter to grow thin layers of bovine cells 400 kilometers above Earth. This proof-of-concept demonstrated tissue formation independent of natural resources or gravity, with cells expanding to form muscle-like structures. A subsequent mission under the Aleph Zero banner occurred in April 2022 as part of Israel's Rakia Mission to the ISS, organized by the Ramon Foundation in collaboration with Axiom Space, NASA, and the Israel Ministry of Science and Technology; it tested cow cell growth and viability in reduced gravity among 44 total experiments, yielding data on proliferation rates but no full-scale tissue production. These efforts highlight incremental progress in understanding microgravity's effects on bioprocessing, though scalability and nutritional equivalence to Earth-grown meat require further verification through peer-reviewed analyses.^[71]^[72]^[73]^[74]

Microgravity Experiments and Implications

In September 2019, Aleph Farms conducted its inaugural microgravity experiment aboard the International Space Station (ISS), marking the first instance of cultivated meat production in space. Bovine cells were transported to the ISS, where they were bioprinted into thin muscle fibers using a 3D bioprinter developed in collaboration with 3D Bioprinting Solutions; the process yielded a small, functional piece of muscle tissue without requiring live animals or Earth-bound resources like extensive water or feed.^[71]^[68] This proof-of-concept demonstrated that cell proliferation and differentiation could occur in microgravity, albeit on a microscopic scale limited by the experiment's constraints.^[75] A subsequent experiment launched in April 2022 as part of the Rakia Mission—the first private Israeli crewed mission to the ISS—focused on advancing muscle tissue maturation under microgravity. Cow cells were cultured in a specialized microfluidic device provided by SpacePharma, enabling automated control of nutrient delivery and environmental conditions to observe proliferation, differentiation, and fusion into multicellular structures resembling steak tissue.^[74]^[68] Samples returned to Earth for analysis revealed that microgravity altered cell alignment and growth patterns compared to terrestrial controls, with cells exhibiting reduced sedimentation and potentially enhanced three-dimensional structuring due to the absence of gravitational settling.^[76] However, quantitative data on yield efficiency or scalability remain proprietary, with Aleph Farms reporting procedural successes but no peer-reviewed publications detailing comparative growth rates as of 2023.^[77] These experiments highlight microgravity's unique biophysical effects on cellular agriculture, where the lack of buoyancy-driven separation may facilitate more uniform tissue assembly, potentially bypassing some Earth-based bioreactor limitations like shear stress from stirring.^[68] Implications extend to enabling on-site protein production for deep-space missions, such as Mars expeditions, where resupply logistics demand compact, recyclable systems; Aleph Farms posits that cultivated meat could utilize recycled astronaut wastewater and minimal biomass, contrasting with the 15,000 liters of water required for 1 kg of conventional beef.^[73]^[71] On Earth, insights from altered cell behaviors could inform bioreactor designs for denser tissue cultivation, though critics note unproven scalability in zero-gravity sterility and energy demands, with no evidence yet of cost-competitive outputs.^[73] Overall, the work underscores cultivated meat's adaptability to extreme environments but relies on further validation beyond demonstration-scale tests.

Challenges and Criticisms

Financial and Operational Hurdles

Aleph Farms has encountered significant financial pressures amid a broader contraction in cultivated meat investment. By February 2025, the company, which had raised approximately $140 million since its founding, was reportedly struggling to secure additional funding, leading to a 73% reduction in its valuation during an ongoing round initiated in 2024.^[8] ^[78] This adjustment reflected adapting to "changing market conditions," with Aleph seeking at least $25 million to stabilize operations.^[10] In response, the firm implemented job cuts, signaling acute cash flow constraints despite prior investments from entities like Cargill and SoftBank.^[79] Operationally, scaling production remains a core challenge for Aleph Farms, particularly in achieving cost-effective cell differentiation and bioreactor yields for whole-cut beef. The company opened a 65,000-square-foot facility in Rehovot, Israel, in 2022 to advance commercialization, yet persistent technological hurdles have delayed profitability, with CEO Didier Toubia noting revised business plans in early 2023 to prioritize cost reductions.^[10] ^[52] In March 2025, Aleph raised $29 million partly to modify its core technology, introducing a lower-cost variant of its whole-cut process aimed at bridging the gap to industrial-scale viability, though full production scaling is projected no earlier than late 2026.^[23] These efforts underscore industry-wide difficulties in reconciling high R&D expenses with the need for affordable media, scaffolds, and bioprocessing, where empirical data indicate that current yields fall short of economic thresholds without further breakthroughs.^[8]

Broader Industry Skepticism and Debates

The cultured meat sector, encompassing initiatives like those of Aleph Farms, encounters widespread skepticism over its potential to disrupt traditional animal agriculture on a large scale. Analysts have forecasted that 70-90% of companies in the field could fail within the coming year, citing persistent hurdles in achieving cost parity with conventional meat through bioreactor scaling and media optimization.^[80] Lifecycle assessments reveal that energy demands for cell proliferation and maintenance could render production carbon-intensive, with one 2023 study estimating emissions up to 25 times higher than retail beef under current protocols reliant on purified growth media and continuous aeration.^[41] ^[81] Proponents' environmental superiority claims often hinge on optimistic assumptions about future renewable energy integration and waste heat recovery, yet empirical data from pilot-scale operations indicate no clear long-term greenhouse gas reductions compared to improved pasture-based systems.^[82] Debates intensify around nutritional profiles and safety, where cellular agriculture products may diverge from whole-muscle meat in micronutrient density and lipid composition due to controlled culturing conditions lacking natural animal stressors. A 2023 joint FAO-WHO analysis cataloged 53 potential hazards, including microbial contamination risks from immortalized cell lines and unintended bioactive compounds from genetic modifications or serum substitutes.^[83] Consumer and regulatory wariness persists, with surveys showing low willingness to adopt amid unresolved questions on allergenicity and long-term digestibility, compounded by limited peer-reviewed feeding trials beyond short-term rodent models.^[84] ^[42] Broader critiques from farming communities highlight opacity in industry funding—often tied to venture capital with ideological leanings toward disrupting livestock sectors—and question whether cellular methods address root causes like over-reliance on monoculture feed crops more effectively than precision grazing or methane-capture technologies.^[85] Skeptics argue that hype around "sustainability" overlooks causal realities, such as the thermodynamic inefficiencies of deriving complex proteins from glucose fermentation versus solar-driven rumen digestion, potentially diverting resources from verifiable agricultural reforms.^[86] While some firms report unit economics progress, systemic dependencies on rare earth-dependent bioreactors and proprietary scaffolds raise doubts about global replicability without subsidies.^[36]

References

[1]
Leadership Team - Aleph Farms
Aleph Farms is a cellular agriculture company. We design new ways to grow quality animal products that improve sustainability, food security, and animal welfare ...
[2]
Aleph Farms - Crunchbase Company Profile & Funding
Aleph Farms is an Israel-based food technology company designing new ways to grow quality animal products that improve sustainability, food security and animal ...
[3]
Aleph Farms - Products, Competitors, Financials, Employees ...
Aleph Farms was founded in 2017. Where is Aleph Farms's headquarters? Aleph Farms's headquarters is located at 1 Haim Holtzman Street, Rehovot. What is Aleph ...
[4]
Aleph Farms - Startup Nation Finder
Founded in 2017, the company utilized cellular agriculture technology to unveil the world's first cultivated thin-cut steak in 2018, the world's first ...
[5]
Aleph Farms Granted World's First Regulatory Approval for ...
Aleph Farms received the first regulatory approval for cultivated beef, the first non-chicken cultivated meat, and the first in the Middle East. It is the ...<|separator|>
[6]
Aleph Farms Announced as Fast Company's 2022 Finalist
We have been recognized for cultivating the world's first slaughter-free ribeye steak using 3D bioprinting technology and the natural building blocks of meat — ...
[7]
Cooking up a New Way Forward with World-class Investors
Aleph Farms received $105 million in Series B funding to scale up manufacturing, expand product lines, and grow operations internationally. They are the first ...
[8]
Aleph Farms raised $140 million—but now it's struggling to survive
Feb 24, 2025 · "In recent months, Aleph Farms has achieved significant breakthroughs, including a 97% reduction in production costs compared to 2022, signing ...
[9]
Israeli Cultivated Meat Startup Aleph Farms Cuts 30% of Local Staff
Jun 6, 2024 · Israeli cultivated meat startup Aleph Farms has conducted layoffs in its local workforce amid difficulties in securing investment.
[10]
Aleph Farms faces funding challenges amid market shifts
Feb 25, 2025 · ISRAEL - Israeli cultivated meat company Aleph Farms is reducing its valuation by 73% in an ongoing funding round, citing the need to adjust ...
[11]
First of its kind independent TEA shows Aleph Cuts will reach 47 ...
Aleph Farms is one of the only companies in the cultivated meat space relying on non-modified cells (non-GMO, non-immortalized), an approach which was generally ...
[12]
Aleph Farms Raises Whopping $105M For Cultured, Slaughter-Free ...
Jul 7, 2021 · Aleph Farms was founded in 2017 by Dr. Didier Toubia and Professor Shulamit Levenberg of the Biomedical Engineering Faculty at the Technion – ...
[13]
Cultured Meat Startup Aleph Farms Raises $12m Series A from ...
May 14, 2019 · Aleph Farms, an Israel cell cultured meat startup, has raised $12 million in Series A funding led by Singaporean investor VisVires New Protein.
[14]
Aleph Farms gets $105 million investment to bring lab-grown steaks ...
Jul 7, 2021 · Aleph Farms was founded in 2017 by Toubia, The Kitchen Hub of the Strauss Group, and Prof. Shulamit Levenberg from the Biomedical Engineering ...
[15]
Aleph Farms 2025 Company Profile: Valuation, Funding & Investors
When was Aleph Farms founded? Aleph Farms was founded in 2017. Where is Aleph Farms headquartered? Aleph Farms is headquartered in Rehovot, Israel.Missing: founders | Show results with:founders
[16]
Aleph Farms Raises €12M to Become the First to Sell Lab-Grown ...
May 16, 2019 · Aleph Farms has closed a Series A round of €10.7M ($12M) to beef up its manufacturing and get its lab-grown steaks into the market within ...Missing: initial | Show results with:initial
[17]
Aleph Farms Completes $105 Million Series B Funding Round
Jul 7, 2021 · The company's Series A funding round was led by VisVires New Protein, with participation from Peregrine Ventures and Strauss Group, as well as ...
[18]
Aleph Farms: Cultivating a solution to climate change and ... - EIT Food
Feb 19, 2025 · Aleph Farms has closed Series A and B funding rounds and raised more than US$140 million since 2018. ... Aleph Farms: Israel Grants World's First ...<|separator|>
[19]
Cultured Meat is The New Way To Steak | Aleph Farms
Aleph Farms uses cells from Lucy's fertilized egg, grown in a controlled environment, and then structured with a plant protein matrix to create the meat.
[20]
What is Cultivated Meat? FAQs - Aleph Farms
Aleph Farms answers your questions about cultivated meat: how it's made, what it tastes like and how long it takes to cultivate steak.
[21]
The science behind the world's first cultivated steak - Aleph Farms
Mar 30, 2020 · The food company made history when it revealed the world's first slaughter-free steaks, cultivated outside of the animal's body under controlled conditions.
[22]
Using 3D Bioprinting for Thicker & Marbled Cultivated Steaks
Recent research findings discuss the 3D bioprinting technique Aleph Farms uses to produce the world's first cultivated ribeye steak. Learn more.
[23]
Aleph Farms raises $29m, modifies core tech to cut costs
Mar 25, 2025 · Israeli cultivated meat startup Aleph Farms has raised $29 million and expects to raise a further $10–15 million in the coming months.
[24]
Aleph Farms and BioRaptor Launch AI-Powered Collaboration to ...
We are proud to announce a new collaboration with BioRaptor, which uses data and AI to streamline and optimize bioprocesses.
[25]
World's first lab-grown steak revealed – but the taste needs work
Dec 14, 2018 · The first lab-grown beefburger, in 2013, cost €250,000. Toubia said the cost would come down as the production process was moved from the lab to ...
[26]
Aleph Farms & The Technion Reveal First Cultivated Ribeye Steak
The cultivated ribeye steak uses 3D bioprinting with real cow cells, has real muscle and fat, and is a thicker cut with similar organoleptic attributes.Missing: innovations | Show results with:innovations
[27]
Aleph Farms, Technion Debut 'World's First' Cultivated Ribeye Steak
Feb 10, 2021 · Israeli clean meat startup Aleph Farms has partnered with the Technion to unveil its 3D printed ribeye steak made from cow cells.
[28]
Aleph Farms Launches New Product Brand Aleph Cuts
Apr 19, 2023 · Under the Aleph Cuts brand, the company will market its first product, the Petit Steak, the world's first cultivated steak anticipated to launch ...
[29]
Aleph Farms makes history as world's first cutlivated beef is ...
Jan 18, 2024 · Aleph farms says the first cut to be introduced to diners in Israel will be the cultivated Petit Steak, made of non-modified, non-immortalized ...Missing: date | Show results with:date
[30]
Aleph Farms Reveals Its Strategy to Replace the Whole Cow
Aleph Farms aims to replace the whole cow by producing cell-cultured collagen from living cow cells, eliminating the need to slaughter animals.
[31]
Aleph Farms Eyes Europe with Cultivated Beef Facility in Switzerland
Sep 11, 2025 · And last week, an independent analysis showed that Aleph Farms's steak could be produced at $6.45 per lb and sold in wholesale for $12.25, ...
[32]
Aleph Farms achieves breakthrough as independent study confirms ...
Sep 2, 2025 · Unlike many cultivated meat startups, Aleph Farms has chosen to work with non-modified, non-immortalized cells, a strategy often regarded as ...
[33]
BioRaptor and Aleph Farms use AI to lower the costs of cultivated beef
May 2, 2024 · Aleph Farms and BioRaptor have teamed up to use AI to improve the tech and lower the costs for creating cultivated beef.
[34]
A conversation about cultivated meat | Nature Communications
Dec 14, 2023 · At Aleph Farms, we're taking a multifaceted approach to overcoming at-scale production costs: - We establish strategic supply chain agreements ...
[35]
Aleph Farms' Didier Toubia on GLP-1s and protein trends
Sep 15, 2025 · Blending cultivated meat with plant-based ingredients isn't a stop-gap for Aleph Farms, explains co-founder and CEO Didier Toubia.Missing: achievements | Show results with:achievements
[36]
Scaling Cultured Meat: Challenges and Solutions for Affordable ...
Jul 9, 2025 · Although the cost of CM has dropped dramatically—from $2.3 million/kg for the first cultured beef burger to $63/kg—it remains prohibitively ...
[37]
5 Challenges of Cultivated Meat Today | Aleph Farms
On the other hand, factory farming raises significant concerns about environmental degradation, antibiotic overuse, and animal welfare, emphasizing the need for ...
[38]
[PDF] Aleph Farms Impact Report 2022
Aleph Farms aims to tackle food security and nature conservation, using cellular agriculture to reduce pressure on livestock farming and provide sustainable ...
[39]
Aleph Farms Unveils Roadmap For Achieving Net Zero Carbon By ...
Nov 3, 2021 · CE Delft recently conducted a study that found cultivated meat has the potential to reduce the carbon footprint of beef production by 92% when ...
[40]
Sustainable Food is Our Promise | Aleph Farms
Aleph Farms focuses on environmental, economic, social, and health & nutrition sustainability, aiming for a just transition to sustainable food systems.
[41]
Lab-Grown Meat Potentially Worse For The Climate Than Beef
May 22, 2023 · Cultured meat is not inherently better for the environment. · Leaping from “pharma to food” product is a significant technological challenge.<|separator|>
[42]
Full article: Reassessing the sustainability promise of cultured meat
Feb 21, 2025 · This review aims to provide a much needed discussion on the latest research findings concerning the nutritional and environmental sustainability of CM
[43]
Food startups Aleph Farms and Iron Ox grow from net zero roots
Dec 15, 2022 · Aleph Farms launched in 2017. In 2020, it became perhaps the first lab-grown meat startup to commit to reach net zero CO2 in five years within ...
[44]
The Myth of Cultured Meat: A Review - PMC - NIH
Among the solutions, cultured meat is presented by its advocates as a sustainable alternative for consumers who want to be more responsible but do not wish to ...
[45]
[PDF] Ex-ante life cycle assessment of commercial-scale cultivated meat ...
Aleph Farms. Cultivated meat production (Bovine). Avant Meats. Cultivated meat production (Fish). Mosa Meat. Cultivated meat production (Bovine). Shiok Meats.
[46]
[PDF] Review and gap-analysis of LCA-studies of cultured meat
This chapter describes the methodology and data used of the publications reviewed It includes the respective scope such as functional unit, system boundary, ...
[47]
Cultivated meat could slash climate impact of meat production by up ...
Mar 9, 2021 · This life cycle assessment and techno-economic assessment are the first reports to be informed by data contributed by companies involved in the ...
[48]
Cultured meat claims "overly ambitious, not supported by evidence ...
Mar 11, 2025 · A newly published study has examined existing research on cultured meat and has found that many of the industry's claimed sustainability and nutritional ...
[49]
Aleph Farms receives green light from Israel for cultured beef
Jan 17, 2024 · Aleph Farms was issued a “no questions” letter on Tuesday from the Israel Ministry of Health that granted it pre-approval for the sale of its ...<|control11|><|separator|>
[50]
Global Approval for Cultivated Beef Signals Industry Growth
Jan 30, 2024 · Aleph Farms in Israel became the third company in the world to win approval for cultivated meat, setting a precedent for the industry's ...
[51]
Aleph Farms CEO on Cultivated Meat Launch & Regulatory Plans ...
Sep 25, 2025 · To date, Aleph Farms has raised $147M, including the $29M it announced from the SAFE conversion and new funding. Now, it's working on a second ...
[52]
Aleph Farms CEO on bid to reach cultivated-meat profitability
Sep 23, 2025 · “The goal is not to replace meat but to diversify choices and provide a unique value proposition” – CEO Didier Toubia.
[53]
[PDF] Report Name:Israeli Government Finds Cultivated Beef to be Safe ...
Feb 28, 2024 · Aleph Farms explains the process on its website. First, the cells taken from the developed egg are preserved at sub-zero temperatures. A limited ...
[54]
Aleph Farms Submits Application to Swiss Regulators, Marking the ...
Aleph Farms has submitted an application for regulatory approval to the Swiss Federal Food Safety and Veterinary Office (FSVO) with the goal of selling Aleph ...
[55]
Aleph Farms Applies to Sell Lab-Grown Meat in Thailand
Dec 5, 2024 · Israeli startup Aleph Farms has submitted the first application for cultivated meat in Thailand, and expects regulatory clearance by mid-2026.
[56]
Aleph Farms Submits First-Ever Application for Cultivated Meat in ...
A regulatory application for Aleph Cuts has been submitted in coordination with Thai Union, aiming to introduce cultivated beef to the Thai market.
[57]
Future of Foods Podcast: Didier Toubia on Aleph Farms' Strategy for ...
Feb 3, 2025 · As Aleph Farms refines its product, scales production, and navigates regulatory landscapes, the cultivated meat industry inches closer to mainstream adoption.
[58]
Aleph Farms to set up cultivated meat production in Switzerland
Sep 16, 2025 · Aleph Farms to set up cultivated meat production in Switzerland. Facility prepares ground for European commercial launch. Published September 16 ...
[59]
Aleph Farms and Thermo Fisher Scientific Establish Supply Chain ...
Long-term agreement aligns with Aleph's scale-up strategy, stands to make production of cultivated meat more cost-efficient. Aleph Farms and Thermo Fisher ...
[60]
Aleph Farms Partners with BBGI and Fermbox Bio to Increase ...
We are proud to announce a new partnership with BBGI, a manufacturer and distributor of bio-based products, and Fermbox Bio, a synthetic biology research and ...
[61]
Aleph Farms Partners with Biomanufacturing Experts to Build Large ...
Feb 21, 2024 · Aleph Farms Partners with Biomanufacturing Experts to Build Large-Scale Cultivated Meat Facility in Thailand · A central hub in Southeast Asia.
[62]
MOU With ESCO Aster, Facility Acquisition From VBL Therapeutics ...
Aleph Farms has acquired a manufacturing facility in Modi'in, Israel and certain related assets from biotechnology company VBL Therapeutics (Nasdaq: VBLT).
[63]
Aleph Farms Expands As We Gear Up for Global Commercialization
Aleph Farms moves into a 65,000 square foot facility with a pilot production plant, state-of-the-art R&D center and a community center.
[64]
https://agfundernews.com/exclusive-aleph-farms-raises-30m-unveils-lower-cost-version-of-whole-cut-technology/
[65]
Aleph Farms and BRF Partner to Bring Cultivated Meat to Brazil
Under this new agreement, Aleph and BRF will co-develop and produce cultivated meat using Aleph's patented production platforms (BioFarm™). BRF will also ...
[66]
Cargill invests in cultured meat company Aleph Farms
May 14, 2019 · In December 2018, it achieved a world-first by demonstrating it could grow a steak directly from bovine cells.Missing: achievements | Show results with:achievements<|separator|>
[67]
Aleph Farms Launches 'Aleph Zero' Program to Grow Steaks in Space
Oct 21, 2020 · The core mission of the new initiative is centered on introducing new capabilities for locally producing fresh, quality meat even in the most ...
[68]
Space Meat – The Future of Astronaut Food | Aleph Farms
Our space program, Aleph Zero, is a key part of our mission to cultivate quality, delicious animal products, regardless of climate or natural resource ...Missing: core | Show results with:core<|separator|>
[69]
Aleph Farms launches program to grow steaks in space - ISRAEL21c
Nov 2, 2020 · The company's Aleph Zero program aims to advance food security through the ability to produce fresh quality meat independent of local climate ...
[70]
Meat Grown in Space for the First Time Ever
Oct 8, 2019 · On the space station, the experiment involved growing a piece of meat by mimicking a cow's natural muscle-tissue regeneration process. Aleph ...
[71]
Aleph Farms Successfully Completed the First Slaughter-free Meat ...
Oct 7, 2019 · Through joint experiment on the International Space Station (ISS), Aleph Farms has brought forward its mission to provide sustainable food ...Missing: Zero | Show results with:Zero
[72]
Aleph Farms 3D prints cell-cultured meat in space for the first time
Oct 8, 2019 · Israeli cell-based meat startup Aleph Farms said it produced meat on the International Space Station, 248 miles away from any natural ...
[73]
SpaceX: Can meat be grown in space? - BBC
Apr 24, 2022 · Aleph Farms is one of several companies trying to produce "cultured meat" but it is the first to try to do it in space. The company doesn't like ...
[74]
The Count Down to Our Second Experiment in Space! - Aleph Farms
Aleph Farms will be heading to space, again. As part of our space program, Aleph Zero, on March 31, 2022, we will be part of the historic Rakia Mission.
[75]
First meat grown in space lab 248 miles from Earth - The Guardian
Oct 7, 2019 · The Israeli food technology startup Aleph Farms grew the meat on the International Space Station, 248 miles (399 km) away from any natural resources.Missing: Zero | Show results with:Zero
[76]
Could Space Steaks Benefit Earth? - Science Museum Group Blog
Apr 26, 2022 · Back in Israel, Aleph Farms will analyse the results of the new ISS experiments to see how bovine cells fared in microgravity. The hope is that ...<|separator|>
[77]
https://www.foodnavigator.com/Article/2019/10/08/Aleph-Farms-prints-lab-meat-in-space
[78]
Aleph Farms: Cultivated Meat Startup Hits Funding Woes, Adjusts ...
Feb 25, 2025 · Israel's Aleph Farms has cut its valuation by 73% amid funding troubles, but the cultivated meat startup says adapting to "changing market ...
[79]
Israeli cultured meat firm faces financial crisis, cuts jobs - Tech in Asia
Feb 25, 2025 · Aleph Farms, known for its lab-grown beef steak, is facing a major financial crisis. The Israel-based company is seeking US$25 million in funding.
[80]
Cultivated meat: '70-90% of players will fail in the next year'
Nov 20, 2023 · 70-90% of companies in this space are going to fail over the next year, but those that survive will build real businesses and will scale their technologies.Missing: criticisms | Show results with:criticisms
[81]
Lab-grown meat could exacerbate climate change scientists say
Oct 19, 2019 · Since the cultured-meat industry is in such an early stage, it's difficult to assess the actual carbon footprint of producing on a large scale ...
[82]
Review: Will “cultured meat” transform our food system towards ...
The food sustainability award delivered to Aleph Farms from the Academia for a Better World, co-founded by Better World Fund and University of Paris-Saclay.
[83]
Lab-grown meat: promises, pitfalls and unresolved challenges
Feb 4, 2025 · In their first of four reports published in 2023, the FAO and WHO identified 53 potential health risks associated with cultured meat, some of ...
[84]
FSA starts work on cell-based meat; consumers skeptical
Mar 13, 2025 · The Food Standards Agency (FSA) has started work on assessing the safety of lab-grown meat but only a minority of consumers seem to be ...
[85]
Threat or opportunity? An analysis of perceptions of cultured meat in ...
There was particular skepticism over the motivations and lack of transparency (see Wood et al., 2023) from cultured meat companies. This led many of the ...
[86]
Lab-grown meat is supposed to be inevitable. The science tells a ...
Sep 22, 2021 · “New studies show cultivated meat can have massive environmental benefits and be cost-competitive by 2030,” it trumpeted, suggesting that a new ...