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Alvimopan

Alvimopan is a selective, peripherally acting μ-opioid receptor antagonist indicated to accelerate the time to upper and lower gastrointestinal recovery in patients undergoing partial large or small bowel resection surgery with primary anastomosis.^[1] It was previously marketed under the brand name Entereg and is now available as generic alvimopan capsules administered orally as 12 mg capsules; it is restricted to short-term use in hospital settings to mitigate risks associated with prolonged exposure.^[2] As of 2025, alvimopan is available only as a generic medication following the withdrawal of the Entereg brand in 2024.^[3] Alvimopan works by competitively binding to μ-opioid receptors in the gastrointestinal tract, thereby antagonizing the peripheral effects of opioids that delay bowel motility without interfering with central analgesic effects.^[1] Its low systemic absorption (oral bioavailability less than 7%) and limited ability to cross the blood-brain barrier ensure targeted action within the gut, with a half-life of 10 to 17 hours and primary excretion via bile and urine.^[2] This mechanism helps reduce the incidence and duration of postoperative ileus, a common complication following abdominal surgery.^[4] Approved by the U.S. Food and Drug Administration in May 2008, alvimopan is available only through a Risk Evaluation and Mitigation Strategy (REMS) program due to concerns over potential cardiovascular risks, such as myocardial infarction, observed in long-term studies.^[1] The standard regimen involves a single 12 mg dose 30 minutes to 5 hours before surgery, followed by 12 mg twice daily starting the day after surgery, for up to 7 days or 15 doses total, whichever occurs first.^[4] Alvimopan is contraindicated in patients who have taken therapeutic doses of opioids for more than 7 consecutive days immediately prior to surgery. It is not recommended for use in patients with complete gastrointestinal obstruction or severe hepatic or renal impairment.^[1] Common side effects include dyspepsia, anemia, and hypokalemia, while serious adverse events may involve myocardial infarction or allergic reactions.^[4] Clinical trials demonstrated its efficacy in shortening the time to first bowel movement and tolerance of solid food, and may reduce the time to hospital discharge.^[1] As a small-molecule drug with the chemical formula C₂₅H₃₂N₂O₄·2H₂O, alvimopan represents an important adjunct in perioperative care to mitigate opioid-induced postoperative ileus.^[1]

Clinical Use

Indications

Alvimopan is approved by the U.S. Food and Drug Administration (FDA) for accelerating upper and lower gastrointestinal recovery in hospitalized patients following surgeries involving partial resection of the large or small intestine with primary anastomosis.^[5] Although the brand name Entereg's new drug application was withdrawn in 2024 due to lack of marketing, generic alvimopan capsules continue to be available in the US as of 2025.^[3]^[6] This approval, granted in May 2008, targets the management of postoperative ileus (POI) in these specific surgical contexts.^[7] The primary indication focuses on reducing the time to first bowel movement and tolerance of solid food after surgery, as demonstrated in pivotal phase 3 clinical trials.^[8] These trials showed that alvimopan shortened gastrointestinal recovery time by 10 to 20 hours compared to placebo, with consistent benefits across patient subgroups including age and sex.^[8] By acting as a peripherally restricted mu-opioid receptor antagonist, it mitigates opioid-induced bowel dysfunction without affecting central analgesia.^[8] Beyond its approved use, alvimopan has been investigated in enhanced recovery after surgery (ERAS) protocols for bowel resection and radical cystectomy, where it supports faster return of bowel function and reduced hospital stays.^[9] Post-2020 studies have explored its role and cost-effectiveness as rescue therapy for established POI following colorectal or small bowel resection.^[10] Meta-analyses of clinical data confirm alvimopan's efficacy, with a lower incidence of POI (odds ratio 0.57, 95% CI 0.48-0.67) and a reduction in hospital length of stay by approximately 0.5 to 1 day in patients undergoing open abdominal surgeries.^[11] These findings underscore its value in high-risk surgical populations, though benefits are most pronounced in open procedures.^[11]

Dosing and Administration

Alvimopan is administered orally as 12 mg capsules for the management of postoperative ileus following partial large or small bowel resection with primary anastomosis. The initial dose is given 30 minutes to 5 hours prior to surgery, followed by 12 mg twice daily starting the day after surgery until gastrointestinal recovery or hospital discharge, for a maximum of 7 postoperative days or 15 doses total.^[12] Administration is restricted to hospital settings only, with enrolled healthcare facilities required to participate in the FDA's Alvimopan REMS program to promote appropriate short-term inpatient use and prevent long-term therapy. Capsules may be taken with or without food and must be swallowed whole, without crushing, breaking, or chewing.^[12] No dosage adjustments are needed for patients with mild to moderate hepatic or renal impairment, though monitoring for adverse gastrointestinal reactions is advised in these populations; alvimopan is not recommended for severe hepatic impairment or end-stage renal disease. Discontinuation should occur upon evidence of gastrointestinal recovery, such as the first postoperative bowel movement or passage of flatus, or after the maximum treatment duration, whichever comes first.^[12]^[13]

Safety Considerations

Adverse Effects

Common adverse effects of alvimopan, observed in clinical trials for postoperative ileus following bowel resection, include dyspepsia (7.0% incidence versus 4.6% with placebo), anemia (5.2% versus 4.2%), hypokalemia (9.5% versus 8.5%), back pain (3.3% versus 1.7%), and urinary retention (3.2% versus 2.1%); these are primarily mild and involve gastrointestinal or systemic symptoms.^[14] Serious risks associated with alvimopan include a potential for myocardial infarction, particularly with long-term use; in a 12-month study of patients with opioid-induced bowel dysfunction receiving 0.5 mg twice daily, the incidence was 1.3% (7/538) in the alvimopan group compared to 0% (0/267) in the placebo group, which contributed to non-approval for chronic indications.^[15] No increased risk of myocardial infarction was noted in short-term perioperative trials using 12 mg doses up to 7 days, where serious cardiovascular event rates remained below 1%.^[14] Post-marketing reports have included rare cases of hypersensitivity reactions, such as rash or anaphylaxis, though overall serious event rates for short-term use are low.^[16] Risk factors for adverse effects include recent opioid exposure, which may heighten sensitivity and increase gastrointestinal symptoms; additionally, at-risk surgical patients require monitoring for gastrointestinal perforation due to the postoperative context.^[14] Alvimopan is contraindicated in patients on therapeutic opioids for more than 7 consecutive days immediately prior to use.^[14]

Contraindications

Alvimopan is contraindicated in patients who have taken therapeutic doses of opioids for more than 7 consecutive days immediately prior to initiation of therapy, due to heightened gastrointestinal sensitivity in these individuals.^[1] Use of alvimopan is not recommended in patients with complete gastrointestinal obstruction, as no clinical studies have been conducted in this population.^[1] Similarly, it is not recommended in individuals with known hypersensitivity to alvimopan or any of its excipients, and therapy should be discontinued if hypersensitivity reactions occur.^[1] Relative contraindications include severe hepatic impairment (Child-Pugh class C), where use is not recommended owing to limited data and potential for increased exposure and adverse reactions.^[1] Similarly, alvimopan is not advised in patients with severe renal impairment (creatinine clearance <30 mL/min) or end-stage renal disease, as exposure may be elevated without established safety profiles.^[1] A history of myocardial infarction represents another relative contraindication, particularly given observations of increased cardiovascular risk in long-term studies, although short-term use under restricted conditions mitigates this concern.^[1] The rationale for the opioid-related contraindication lies in the physiological adaptation from prolonged exposure, where patients recently using opioids exhibit greater sensitivity to mu-opioid receptor antagonism in the gastrointestinal tract, potentially resulting in exaggerated effects such as abdominal pain, nausea, vomiting, and diarrhea.^[17] Chronic opioid use can lead to upregulation of peripheral mu-opioid receptors, amplifying the peripheral antagonist activity of alvimopan while its limited central penetration avoids significant unopposed central opioid effects.^[18] Under the Alvimopan Risk Evaluation and Mitigation Strategy (REMS) program—as of 2025 applicable to generic formulations following the 2024 withdrawal of the Entereg brand—preoperative screening is mandatory to assess opioid use history (ensuring no more than 7 consecutive days within the prior period) and gastrointestinal status, with therapy limited to a maximum of 15 doses in enrolled hospital settings to prevent misuse and ensure safe application.^[1]^[3]^[19]

Drug Interactions

Alvimopan primarily interacts with opioid medications due to its role as a peripherally acting mu-opioid receptor antagonist, which competitively binds to peripheral opioid receptors in the gastrointestinal tract to reverse opioid-induced inhibition of motility without impacting central analgesia.^[1] In patients receiving opioids for short-term use (≤7 days) prior to surgery, no significant pharmacokinetic alterations occur with intravenous morphine, and no dosage adjustments are required.^[1] However, alvimopan is contraindicated in opioid-tolerant patients who have taken therapeutic doses of opioids for more than 7 consecutive days immediately before initiating treatment, as this can lead to heightened gastrointestinal hypersensitivity and adverse effects such as severe abdominal pain, diarrhea, or bowel perforation.^[1] Alvimopan is not a substrate, inhibitor, or inducer of cytochrome P450 (CYP) enzymes, including CYP3A4, based on in vitro data, making CYP-mediated interactions unlikely.^[14] It is, however, a substrate for P-glycoprotein (P-gp) in vitro, and while no clinical interaction studies with P-gp inhibitors (e.g., cyclosporine or verapamil) have been performed, coadministration with strong P-gp inhibitors may potentially increase alvimopan exposure, warranting caution and monitoring in such cases.^[14] No clinically significant interactions occur with common perioperative medications, including acid blockers (e.g., proton pump inhibitors or H2 antagonists) or antibiotics, as population pharmacokinetic analyses show no impact on alvimopan exposure, though metabolite levels may be modestly reduced (by approximately 49% with acid blockers and 81% with preoperative oral antibiotics), without necessitating dose adjustments.^[1] Similarly, alvimopan does not alter the pharmacokinetics of other drugs via CYP or P-gp inhibition.^[14] In the short-term hospital setting for postoperative ileus, these interactions pose low overall risk when alvimopan is used as directed, but monitoring for changes in gastrointestinal motility is recommended, particularly in patients on opioids or P-gp inhibitors.^[1] Coadministration with other peripheral opioid antagonists (e.g., naldemedine or naloxegol) should be avoided to prevent additive antagonism and potential opioid withdrawal symptoms.^[2]

Pharmacology

Mechanism of Action

Alvimopan is a selective antagonist of the μ-opioid receptor, exhibiting high affinity with a dissociation constant (Ki) of 0.4 nM and no measurable agonist or partial agonist activity in vitro.^[5] It demonstrates greater binding affinity for μ-opioid receptors compared to δ- and κ-opioid receptors, ensuring specificity for its primary target without significant interaction at other opioid receptor subtypes.^[20] This selective antagonism occurs primarily at peripheral μ-opioid receptors in the gastrointestinal tract, where alvimopan competitively binds and displaces opioid agonists.^[2] By blocking μ-opioid receptors in the enteric nervous system, alvimopan inhibits the opioid-induced suppression of gastrointestinal propulsive activity, thereby preventing the delay in peristalsis caused by exogenous opioids.^[5] It counteracts the reduction in acetylcholine release from enteric neurons and the associated impairment of fluid secretion in the gut, restoring normal bowel motility without interfering with central analgesic effects.^[21] In preclinical models, such as isolated guinea pig ileum, alvimopan effectively reverses morphine-induced inhibition of contractility, highlighting its role in normalizing gastrointestinal function.^[5] Alvimopan's peripheral restriction is facilitated by its limited penetration of the blood-brain barrier, attributed to its substrate status for P-glycoprotein efflux transporters, which actively pump the drug out of the central nervous system.^[22] This pharmacokinetic property, combined with low lipophilicity and large molecular weight, confines its antagonistic effects to peripheral tissues, particularly enteric neurons, while sparing brain μ-opioid receptors responsible for analgesia.^[20] As a result, alvimopan maintains the therapeutic benefits of opioid pain relief without compromising them through central antagonism.^[2]

Pharmacokinetics

Absorption

Alvimopan exhibits low oral bioavailability of approximately 6% (range 1% to 19%), primarily attributed to its extensive first-pass hepatic metabolism and limited intestinal absorption due to P-glycoprotein-mediated efflux in the gut wall.^[5]^[23] The molecule's zwitterionic nature at physiological pH contributes to its low solubility and poor permeability across the gastrointestinal epithelium, further restricting systemic entry.^[5] Following oral administration in the fasted state, alvimopan is rapidly absorbed, achieving maximum plasma concentration (C_max) at approximately 2 hours post-dose.^[5]^[24] Administration with a high-fat meal delays absorption, prolonging T_max by about 1 hour, reducing C_max by 38%, and modestly decreasing the area under the curve (AUC) by 21%, though the overall extent of absorption remains largely preserved for clinical purposes.^[5]^[24] Pharmacokinetics of alvimopan demonstrate dose proportionality in plasma exposure over the clinically relevant range of 6 to 18 mg, with linear increases in C_max and AUC.^[5] At steady state, achieved after approximately 2 to 3 days of twice-daily dosing based on its elimination half-life of 10 to 18 hours, there is minimal accumulation of the parent drug.^[25]^[26] The 12 mg capsule formulation supports consistent bioavailability without significant influence from variations in gastric pH or mild gastrointestinal motility alterations, ensuring reliable absorption in postoperative settings.^[5]

Distribution

Alvimopan exhibits a steady-state volume of distribution of approximately 30 L (range: 20–40 L), indicating moderate penetration into body tissues with a primary focus on the gastrointestinal tract. This volume reflects the drug's limited systemic spread beyond peripheral compartments, consistent with its design as a peripherally acting agent.^[14] The extent of plasma protein binding for alvimopan is approximately 80%, primarily to albumin, while its major metabolite is bound to about 94%; binding is independent of concentration and limits the unbound fraction available for further tissue distribution and potential peripheral effects.^[14] Alvimopan demonstrates pronounced tissue selectivity, with high accumulation in enteric tissues attributable to the dense expression of mu-opioid receptors in the gastrointestinal tract; radiolabeled studies confirm that its activity is largely confined to this region. In contrast, brain penetration is negligible due to the drug's large polar structure and its role as a substrate for P-glycoprotein, an efflux transporter at the blood-brain barrier that restricts central nervous system entry.^[27]^[14]^[28] In special populations, the distribution of alvimopan remains unchanged in elderly patients, with no clinically significant age-related alterations requiring dosage adjustments. Similarly, no notable differences occur in individuals with mild to severe renal impairment, though the drug has not been evaluated in end-stage renal disease.^[14] Pharmacokinetics are unaffected by sex. In Japanese patients, alvimopan exposure is approximately 2-fold higher; monitoring for adverse reactions is advised. Metabolite exposure is lower in Black (43%) and Hispanic (82%) patients compared to Caucasians, but no dosage adjustment is needed.^[1]

Metabolism

Alvimopan undergoes minimal hepatic metabolism and is not a substrate for cytochrome P450 (CYP) enzymes, including CYP3A4.^[1] Instead, its primary biotransformation occurs via intestinal flora, which hydrolyzes the amide bond to produce the active metabolite ADL 08-0011.^[1] This metabolite retains mu-opioid receptor antagonist activity with a binding affinity (Ki) of 0.8 nM, comparable to that of the parent compound.^[29] The gut-mediated hydrolysis pathway limits systemic absorption, contributing to alvimopan's low oral bioavailability of approximately 6% (range 1%–19%).^[1] Although ADL 08-0011 enters the systemic circulation in small amounts, it remains peripherally restricted due to its poor penetration of the blood-brain barrier, thereby supporting prolonged peripheral antagonism without central effects.^[20] Biliary secretion facilitates the delivery of unabsorbed alvimopan to the intestines, where microbial metabolism predominates.^[1] Alvimopan and its metabolite do not significantly induce or inhibit CYP enzymes (1A2, 2C9, 2C19, 2D6, or 3A4), minimizing potential impacts on the metabolism of co-administered drugs via these pathways.^[30] This lack of interaction with hepatic enzymes further underscores the dominance of non-hepatic, flora-dependent biotransformation in alvimopan's disposition.^[20]

Elimination

Alvimopan exhibits an elimination half-life ranging from 10 to 17 hours following multiple oral doses, with a mean of approximately 11 to 12 hours, supporting a twice-daily dosing regimen for short-term use.^[1] The total plasma clearance of alvimopan averages 402 mL/min (with a standard deviation of 89 mL/min), indicating efficient systemic removal without significant accumulation during brief therapeutic courses.^[1]^[2] The primary route of elimination for alvimopan is biliary secretion, accounting for approximately 65% of total clearance, with the unchanged drug and its metabolites excreted predominantly in feces via the bile.^[1]^[31] Renal excretion contributes about 35% to overall clearance, primarily involving metabolites such as the glucuronide conjugate rather than the parent compound.^[1] Hepatic metabolism plays a minimal role in the elimination process, as the drug is largely cleared unchanged or as gut-derived metabolites.^[1]^[20] In patients with severe renal impairment, the half-life of alvimopan may be prolonged up to around 20 hours, leading to 2- to 5-fold higher exposure to its metabolites, though no dosage adjustment is required for mild to severe cases; use is not recommended in end-stage renal disease.^[31]^[1] In patients with mild or moderate hepatic impairment, exposure to alvimopan tends to be 1.5- to 2-fold higher than in healthy subjects. In severe hepatic impairment, exposure may be similar or up to 10-fold higher; alvimopan is not recommended for use in patients with severe hepatic impairment.^[1]

History and Regulation

Development

Alvimopan was developed by Adolor Corporation in the early 2000s as a selective, peripherally acting mu-opioid receptor antagonist (PAMORA) designed to mitigate opioid-induced constipation and bowel dysfunction by targeting peripheral opioid receptors in the gastrointestinal tract, thereby avoiding central nervous system interference that could compromise analgesia.^[32] The compound, initially designated ADL 8-2698, emerged from Adolor's research into novel opioid modulators to address unmet needs in perioperative and chronic opioid-related gastrointestinal disorders.^[33] Preclinical studies in animal models, including rats, guinea pigs, and ferrets, demonstrated alvimopan's ability to restore gastrointestinal motility delayed by opioids, such as morphine, without reversing analgesic effects or crossing the blood-brain barrier to any significant degree.^[34]^[35] These findings were supported by in vitro assays showing competitive antagonism at mu-opioid receptors in isolated guinea pig ileum preparations.^[17] Subsequent phase 1 trials in healthy volunteers confirmed the drug's peripheral selectivity, with dose-escalation studies up to 54 mg daily revealing no central opioid withdrawal symptoms and minimal systemic effects on analgesia or pupillary response.^[36] Phase 2 clinical trials conducted between 2004 and 2006 evaluated alvimopan's efficacy in postoperative ileus (POI) following bowel resection and gynecologic surgeries, showing accelerated gastrointestinal recovery—such as reduced time to first bowel movement by up to 41 hours—compared to placebo, with a favorable safety profile.^[24] These results informed larger pivotal phase 3 trials in patients undergoing partial large- or small-bowel resection under opioid analgesia, where alvimopan 12 mg twice daily shortened GI recovery by 11 to 26 hours and hospital discharge by 13 to 21 hours across multiple studies involving over 2,500 patients, providing key data for regulatory submission.^[17]^[37] Adolor's development program initially encompassed both acute POI and chronic opioid-induced bowel dysfunction (OIBD), in collaboration with GlaxoSmithKline (GSK), but the chronic arm was discontinued in December 2008 following an evaluation that identified potential cardiovascular risks, including an imbalance in myocardial infarction events observed in long-term exposure studies.^[38]^[39] Adolor regained full rights to alvimopan from GSK in 2008 and was acquired by Cubist Pharmaceuticals in 2011 for up to $415 million, integrating the drug into Cubist's portfolio; Cubist was subsequently acquired by Merck & Co. in 2015.^[40]

Regulatory Approvals and Status

Alvimopan, marketed as Entereg, received approval from the U.S. Food and Drug Administration (FDA) on May 20, 2008, for short-term use to accelerate upper and lower gastrointestinal recovery in hospitalized patients following partial large- or small-bowel resection surgery with primary anastomosis, provided they had not received therapeutic opioid doses for more than seven consecutive days prior to surgery.^[41] In 2010, the FDA modified the associated Risk Evaluation and Mitigation Strategy (REMS) following observations of increased myocardial infarction risk in a chronic opioid-induced bowel dysfunction study, restricting distribution to hospital-only use to enhance patient safety.^[42] The Entereg Access Support and Education (E.A.S.E.) REMS program mandates enrollment of qualified hospitals and prescribers, limits dispensing to a maximum of 15 doses per patient for inpatient short-term administration, and prohibits any outpatient use or distribution to mitigate potential cardiovascular risks, including myocardial infarction with prolonged exposure.^[43] A submission for alvimopan to Health Canada was cancelled by the sponsor on March 29, 2017, following a Notice of Noncompliance issued on January 10, 2017, due to deficiencies in the Chemistry and Manufacturing information. No marketing authorization has been granted in Canada.^[44] It has not received centralized approval from the European Medicines Agency and lacks national authorizations in major European markets, though it may be accessible through imports in limited cases.^[45] As of 2025, alvimopan maintains ongoing availability in the U.S. market, bolstered by FDA approvals of generic versions, including a supplemental abbreviated new drug application on September 23, 2025, following the 2024 withdrawal of the original brand's new drug application due to discontinued marketing by its holder.^[19]^[3] Its use has grown within Enhanced Recovery After Surgery (ERAS) protocols for elective colorectal and other abdominal procedures, with continued regulatory monitoring for long-term safety, particularly cardiovascular events.^[46]

References

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None
### Encyclopedia Intro Summary on Alvimopan (ENTEREG)
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Alvimopan is an opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel ...
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Feb 1, 2025 · Alvimopan is used to help restore normal bowel function in patients who have just had bowel resection surgery.
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Initial U.S. Approval: 2008 ... There were more reports of myocardial infarctions in patients treated with alvimopan. 2. This label may not be the latest approved ...
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Adolor Corporation and GlaxoSmithKline Announce FDA Approval ...
May 20, 2008 · Entereg is indicated to accelerate upper and lower gastrointestinal recovery following partial large or small bowel resection surgery with ...<|control11|><|separator|>
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Conclusions: Alvimopan significantly accelerated GI recovery in BR patients. A 12-mg dose provided more consistent benefits across both sexes and all ages.
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Mar 26, 2021 · Patients undergoing radical cystectomy and managed by an Enhanced Recovery After Surgery protocol experience a significantly shorter length of hospital stay ...
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Alvimopan as a Rescue Treatment of Postoperative Ileus
This study aims to evaluate the cost effectiveness of Alvimopan as rescue therapy in patients undergoing colorectal or small bowel resection who develop POI ...
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Effect of Alvimopan on Postoperative Ileus and Length of Hospital ...
Jul 20, 2024 · Robust evidence supports the routine use of alvimopan in patients undergoing open bowel resection as indicated by lower risk of postoperative ileus and shorter ...Missing: ratio | Show results with:ratio
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ENTEREG capsules for oral administration contain 12 mg of alvimopan on an anhydrous basis ... 36 hours following administration of a single dose of alvimopan.
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Dec 10, 2023 · The recommended adult dosage of ENTEREG is 12 mg administered 30 minutes to 5 hours prior to surgery followed by 12 mg twice daily beginning the day after ...
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In vitro studies suggest that alvimopan and its 'metabolite' are substrates for p glycoprotein. A population PK analysis did not reveal any evidence that ...
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May 1, 2008 · myocardial infarction) in the alvimopan treatment group, compared to the placebo group, ... 1.3%, respectively. These patients were ...
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In this study, most of the MIs occurred between one month and four months after initiation of treatment. This imbalance has not been observed in other studies ...Missing: OIBD | Show results with:OIBD
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Jul 28, 2020 · In vitro studies suggest that alvimopan and its metabolite are substrates for P-gp; however, coadministration of mild-to-moderate P-gp ...
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Alvimopan (Entereg) (1) was approved in the US in 2008 as an oral treatment to ... substrate for the P-glycoprotein efflux transporter (P-gp). Our ...
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Alvimopan (Entereg), approved by the FDA to accelerate upper and lower gastrointestinal (GI) recovery following partial large-bowel or small- bowel resection ...
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12 mg PO administered 30 minutes to 5 hours preoperative, THEN 12 mg PO q12hr beginning 1 day after surgery until discharge for a maximum of 7 days.
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Alvimopan (ENTEREG (TM)), a novel opioid antagonist, achieves ...
Aug 6, 2025 · 3,16 After twice-daily 12-mg dosing, there is little or no accumulation at steady state. 12,16, 25 Moreover, the mean terminal halflife is 14 ...
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Alvimopan: A peripherally selective opioid mu receptor antagonist
Studies using radiolabeled alvimopan indicate that activity is limited to the gastrointestinal (GI) tract. In an in vitro guinea pig ileum assay, alvimopan ...Missing: distribution | Show results with:distribution
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Potential for Alvimopan to Affect the Pharmacokinetics of Other Drugs: Alvimopan and its 'metabolite' are not inhibitors of CYP 1A2, 2C9, 2C19, 3A4, 2D6, and ...
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... bioavailability of approximately 0.03%. The half-life of ADL 8-2698 is ... Effect of dose and exposure protocol on the toxicokinetics and first-pass elimination ...
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Alvimopan, a Novel, Peripherally Acting μ Opioid Antagonist
Alvimopan is a novel, oral, peripherally acting antagonist of the μ opioid receptor that has limited ability to cross the blood-brain barrier and is currently ...Missing: upregulation | Show results with:upregulation
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Results of a Randomized Trial of Alvimopan and Placebo With a ...
Conclusions Alvimopan, 12 mg, administered 30 to 90 minutes before and twice daily after bowel resection is well tolerated, accelerates GI tract recovery ...Missing: steady | Show results with:steady
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Dec 18, 2008 · Following an internal and external evaluation, the Company has determined that it will not pursue further development of alvimopan to treat ...
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May 16, 2008 · In summary, an excess number of myocardial infarctions were reported in a single clinical trial of opioid- induced bowel dysfunction that ...Missing: OIBD | Show results with:OIBD
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May 21, 2008, Approval Adolor and GlaxoSmithKline Announce FDA Approval of Entereg (alvimopan) for the Management of Postoperative Ileus (POI) ; May 9, 2008 ...Missing: indications | Show results with:indications
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### Summary of REMS History for Alvimopan
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Enrollment in the E.A.S.E.. Program permits hospitals performing bowel resection surgeries to receive ENTEREG. It is important that you understand this program ...
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The purpose of this New Drug Submission was to seek approval of alvimopan to accelerate the time to upper and lower gastrointestinal (GI) recovery following ...
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1. EMA Drug Approvals. Approved Product. Authorization Holder. Status. Issued Date. No EMA approvals found for this drug. HSA Drug Approvals. Approved Product.
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Other elements such as the use of chewing gum, coffee and alvimopan are reviewed and evidence-graded. ... © ERAS® Society 2025. All rights reserved. When you ...<|control11|><|separator|>