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Cervical plexus

The cervical plexus is a network of nerve fibers originating from the anterior (ventral) rami of the first four cervical spinal nerves (C1–C4), forming a complex neurologic structure that provides both sensory and motor innervation primarily to the neck, upper anterior torso, and certain muscles of the head and shoulders. It arises within the upper neck, lying deep to the sternocleidomastoid muscle and internal jugular vein, and anterior to the scalenus medius and levator scapulae muscles, with each ramus receiving sympathetic input from the superior cervical ganglion via a grey ramus communicans. The plexus divides into superficial and deep components: the superficial portion emerges laterally from the posterior border of the sternocleidomastoid muscle to supply cutaneous sensation, while the deep portion remains intramuscular to innervate deeper structures. It communicates with nearby cranial nerves, including the facial, hypoglossal, spinal accessory, and vagus nerves, as well as the sympathetic trunk, facilitating integrated innervation of the region. Key sensory branches include the lesser occipital nerve (from C2), which innervates the scalp posterior to the auricle; the great auricular nerve (C2–C3), supplying skin over the parotid gland, mastoid process, and angle of the mandible; the transverse cervical nerve (C2–C3), providing sensation to the anterior and lateral neck; and the supraclavicular nerves (C3–C4), which cover the skin of the upper chest, clavicle, and acromion. Motor branches encompass the ansa cervicalis (C1–C3), which innervates the infrahyoid muscles involved in swallowing and head movement; direct branches to muscles such as the geniohyoid, thyrohyoid, sternocleidomastoid, trapezius, levator scapulae, and scalenus medius; and the phrenic nerve (primarily C4 with contributions from C3–C5), which is crucial for diaphragmatic contraction and respiration. Clinically, the cervical plexus is significant for procedures like regional anesthesia blocks, which target its superficial branches for surgeries involving the neck, thyroid, or carotid artery, often guided by ultrasound to minimize risks such as phrenic nerve palsy or vascular injury. Injuries or neuropathies affecting the plexus can lead to sensory deficits in the neck and shoulder or motor impairments in neck flexion and diaphragmatic function, underscoring its role in both daily mobility and critical respiratory support.

Overview

Definition and Formation

The cervical plexus is a plexiform network of nerve fibers formed by the anterior (ventral) rami of the cervical spinal nerves (C1–C4). This structure arises as the ventral roots from the spinal cord's basal plate extend laterally to form the anterior rami, which then interconnect to create the plexus. The formation involves the interlacing of these rami within the prevertebral layer of the deep cervical fascia that serve as the foundation for subsequent branching. Specifically, the C1 ramus joins the (cranial nerve ) and travels with it before detaching as the descendens hypoglossi, carrying cervical fibers to innervate certain . Each ramus also receives sympathetic input from the via gray rami communicantes, integrating autonomic components into the plexus. Embryologically, the cervical plexus develops from the ventral rami of spinal nerves in the cervical region as part of the peripheral nervous system formation following development. This foundational was detailed in seminal texts such as Gray's Anatomy: The Anatomical Basis of Clinical Practice (42nd edition, 2020), with no substantive updates to its core formation and structure reported since.

Location and General Structure

The plexus is situated to the and lies lateral to the transverse processes of the C1-C4 vertebrae. It is positioned within the , specifically between the prevertebral anteriorly and the posteriorly. This arrangement places the plexus anterior to the and posterior to the , to the investing layer of the . Formed from the anterior rami of the C1-C4 spinal nerves, the cervical plexus exhibits a general structure divided into superficial and deep divisions. The superficial division primarily provides , whereas the deep division supplies motor innervation to muscles. These divisions arise from interconnecting loops of the ventral rami, contributing to the plexus's organized layout in the upper region. The plexus emerges at the "nerve point of the neck," located in the approximately 2-3 cm superior to the , near the midpoint of the posterior border of the . Surrounding landmarks include the and anteriorly, as well as the scalenus medius and levator scapulae muscles posteriorly. In adults, the cervical plexus extends from the to the . This vertical extent underscores its role in bridging upper cervical structures with supraclavicular regions.

Anatomy

Components and Loops

The cervical plexus exhibits an internal organization characterized by a three-loop system, formed by the anterior rami of the first four cervical spinal nerves (C1-C4). The superior loop arises from the union of C1 and C2 rami, the middle loop from C2 and C3, and the inferior loop from C3 and C4; these loops interconnect via rami communicantes, facilitating fiber exchange between levels and contributing to the plexus's integrated neural architecture. The plexus divides into superficial and deep components, each serving distinct roles in innervation. The superficial division comprises primarily cutaneous branches originating from C2 and C3, emerging laterally from the posterior border of the sternocleidomastoid muscle to supply sensory fibers to the skin. In contrast, the deep division encompasses motor branches from C1 to , including a key contribution to the (primarily C3-C5, with input from the cervical plexus), which descends to innervate the . Internally, fibers within the loops intermingle extensively before segregating into specific pathways, enabling a of sensory and motor contributions across branches; this occurs deep to the sternocleidomastoid and anterior to the . The C1 ramus frequently lacks a dorsal root, consisting almost entirely of motor fibers that join the to form part of the loop. At the microscopic level, the cervical plexus consists of bundles of myelinated axons—both A-alpha fibers for motor transmission and A-delta/beta fibers for sensory conduction—ensheathed by Schwann cells, which myelinate peripheral nerves and support axonal regeneration following injury.

Branches

The cervical plexus gives rise to superficial and deep branches. The superficial branches emerge from the posterior border of the at its midpoint, known as the nerve point of the neck. These branches form through the interconnected loops of the anterior rami of C1-C4 spinal nerves. Except for the , which arises higher from the superior aspect of the plexus, the superficial branches exit via this common point.

Superficial Branches

The superficial branches, also termed cutaneous branches, provide coverage to the skin of the , , and upper . They include the lesser occipital, great auricular, transverse cervical, and supraclavicular nerves.
  • The lesser occipital nerve arises from , with occasional contributions from C3. It emerges at the nerve point and ascends along the posterior border of the sternocleidomastoid muscle, curving around the accessory nerve to reach the posterosuperior aspect of the near the auricle.
  • The great auricular nerve originates from and C3. Emerging at the nerve point, it courses superiorly and anteriorly across the sternocleidomastoid muscle, ascending diagonally to the and the posterior aspect of the auricle, extending from the angle of the mandible to the mastoid process.
  • The transverse cervical nerve derives from and . It emerges at the nerve point, wraps horizontally around the posterior border of the , and pierces the deep cervical fascia deep to the platysma to reach the .
  • The stem from and C4. They emerge as a single trunk at the nerve point behind the , descend inferiorly, and divide near the into medial, intermediate, and lateral branches that cross over the to the region.

Deep Branches

The deep branches, primarily muscular, extend to various neck muscles and form structures such as loops for distribution. They include segmental nerves to specific suprahyoid and , the , to the levator scapulae and , and the .
  • Segmental branches from C1 travel with the : one to the geniohyoid muscle and another to the . Additional segmental branches from C1-C3 supply the omohyoid, sternohyoid, and sternothyroid muscles via the loop. The itself forms from a superior (C1, sometimes with C2) descending superficial to the and an inferior (C2-C3) joining it in the anterior cervical triangle to create a U-shaped loop.
  • The nerve to the levator scapulae arises from and , emerging within the deep aspect of the to reach the muscle directly. Branches to the originate from C2- and join the spinal accessory nerve (CN XI) before distributing to the muscle.
  • The forms from , , and C5 (primarily ), arising from the superior part of the at the lateral of the anterior scalene muscle. It descends obliquely across the anterior surface of the scalene muscle, posterior to the , and enters the anterior to the root.

Relations and Communications

The cervical plexus is positioned anterior to the middle scalene and levator scapulae muscles, lying directly on their anterior surfaces within the posterior cervical triangle. Anteriorly, it relates to the , , and , which overlie it in the anterior neck. Superiorly, the plexus lies above the at the root of the neck, with its lower components transitioning toward the . Embedded within the prevertebral layer of the deep cervical fascia, the cervical plexus originates near the and extends laterally, enclosed by this fascia that surrounds the and . It remains separated from superficial neck structures, such as the platysma and skin, by the investing layer of the deep cervical fascia, through which its cutaneous branches pierce to emerge. The cervical plexus forms multiple neural communications that facilitate interconnections with adjacent cranial and autonomic nerves. It anastomoses with the , allowing some cervical fibers to contribute to innervation. Via the descendens hypoglossi, it connects to the , conveying C1-C2 fibers for infrahyoid muscle supply. Additional anastomoses occur with the , integrating into the for mucosal innervation, and with the cervical , distributing gray rami for cardiac and vascular regulation. Vascularly, the cervical plexus travels alongside branches of the , including the ascending cervical artery—which arises from the inferior thyroid and ascends along the —and the superficial cervical artery, supplying adjacent musculature. Its proximity to the renders the plexus vulnerable to compression, especially the upper roots, during neck extension when arterial loops may impinge on neural elements. Several branches of the cervical plexus traverse these relations to innervate target structures.

Function

Sensory Innervation

The sensory innervation of the cervical plexus primarily involves the transmission of cutaneous sensations from the of the , , and upper , as well as proprioceptive feedback from deep structures. The cutaneous branches emerge from the superficial division of the plexus and are derived from the anterior rami of spinal nerves through , providing general afferent fibers for touch, , and temperature. These branches pierce the deep cervical fascia to reach the , forming a key component of the peripheral sensory network in the head and region. The lesser occipital nerve, arising mainly from C2 with occasional contributions from C3, supplies sensory innervation to the skin of the posterolateral scalp and the upper part of the auricle. The great auricular nerve, originating from C2 and C3, innervates the skin over the parotid gland, the angle of the mandible, the mastoid process, and the lower external ear. The transverse cervical nerve, also from C2 and C3, provides sensation to the skin of the anterior and lateral neck, extending to the region over the thyroid gland and sternocleidomastoid muscle. The supraclavicular nerves, derived from C3 and C4, distribute to the skin of the upper chest, over the clavicle, acromioclavicular joint, and anterolateral shoulder. These distributions ensure comprehensive coverage of the superficial neck and adjacent areas, with the nerves often anastomosing to overlap sensory territories. In terms of dermatomal mapping, the dermatome corresponds to the sensory areas supplied by the lesser occipital and great auricular nerves, encompassing the and auricular skin. The C3 dermatome covers the great auricular, transverse cervical, and medial regions, including the and upper pectoral skin. The dermatome aligns with the lateral supraclavicular nerves, innervating the acromial and deltoid areas. This segmental organization reflects the embryonic origins of the spinal nerves and aids in clinical localization of sensory disturbances. Beyond cutaneous sensation, the cervical plexus contributes to through its deep branches, which arise from the anterior rami of C1 to and innervate muscles such as the scalenes (anterior, middle, and posterior) and prevertebral group (including capitis and colli). These branches carry afferent fibers that provide feedback on position, muscle stretch, and movement, essential for maintaining and coordinated head movements. Disruption of these pathways can impair kinesthetic awareness of the cervical spine. Sensory inputs from the cervical plexus also participate in pain referral patterns via connections to the trigeminocervical complex, where upper cervical afferents (primarily C1-C3) converge with fibers in the caudal medulla and upper . This convergence allows nociceptive signals from neck structures, such as the upper zygapophyseal joints or , to be referred as headaches, often manifesting in the occipital, frontal, or orbital regions. Such patterns underlie cervicogenic headaches originating from .

Motor Innervation

The motor innervation of the cervical plexus arises primarily from the anterior rami of the C1 to C4 spinal nerves, providing efferent supply to various neck and upper thoracic muscles through deep branches that emerge from the posterior aspect of the plexus. These branches facilitate essential functions such as head stabilization, swallowing, scapular movement, and respiration, with the ansa cervicalis and phrenic nerve serving as key structures. The , a neural loop formed by the superior root (from C1 fibers traveling via the ) and the inferior root (from C2-C3), delivers motor innervation to the infrahyoid strap muscles, including the omohyoid, sternohyoid, and sternothyroid. These muscles depress the and , contributing to and head stabilization during . The thyrohyoid and geniohyoid muscles receive motor fibers from C1 via direct branches from the , aiding in hyoid elevation and stabilization for coordinated neck movements. Direct muscular branches from the cervical plexus (C3-C4) innervate the levator scapulae muscle, enabling scapular elevation and contributing to shoulder girdle stability. Additionally, proprioceptive and minor motor contributions from C2-C4 branches anastomose with the spinal accessory nerve (cranial nerve XI), supporting trapezius function in scapular retraction and head posture maintenance. These deep muscular branches, detailed further in anatomical descriptions of plexus components, underscore the cervical plexus's role in integrating neck and shoulder motor control. The , originating mainly from C4 with contributions from C3 and C5, provides the sole motor innervation to the , the primary muscle responsible for and for the of respiratory effort. This descends anteriorly over the scalenus anterior muscle, passing through the to reach the , where it ensures rhythmic contraction essential for . Motor efferents from the cervical plexus participate in reflex arcs that coordinate cervical muscle responses, supporting head turning and posture maintenance through integration with proprioceptive inputs from muscles. These reflexes involve rapid activation of infrahyoid and muscles to adjust head position in response to vestibular or somatosensory stimuli, promoting balance and stability.

Clinical Significance

Injuries and Pathology

Traumatic injuries to the cervical plexus often occur in penetrating neck trauma or whiplash-associated disorders, where disruption of its branches can lead to sensory deficits in the neck, shoulder, and ear regions, as well as motor weakness in the infrahyoid muscles. In severe cases, such as those involving the phrenic nerve (arising primarily from C3-C5 roots), diaphragmatic paralysis may result, manifesting as dyspnea and respiratory compromise, particularly following blunt or stretch trauma to the neck. For instance, seatbelt injuries or falls have been documented to cause neuromas in superficial branches like the great auricular and lesser occipital nerves, producing chronic neurogenic pain and dysesthesia. Iatrogenic damage to the cervical plexus is a recognized complication of procedures such as carotid endarterectomy and cervical lymph node biopsy, frequently affecting the greater auricular nerve and leading to numbness over the ear and mastoid area. During repeat carotid endarterectomy, the overall incidence of cranial and cervical nerve injuries is approximately 21%, including greater auricular nerve injuries in about 2% of cases, with most resolving transiently within 12 months, though some persist and cause significant sensory impairment. Similarly, inadvertent transection of superficial cervical plexus branches during lymph node excisions in the posterior triangle can result in localized sensory loss, emphasizing the need for anatomical awareness to mitigate such risks. Pathological conditions affecting the cervical plexus include compressive neuropathy from cervical spondylosis, where degenerative changes such as disc bulges or foraminal stenosis impinge on deep branches, causing chronic neck pain and radicular symptoms in the C2-C4 distribution. Additionally, herpes zoster infection involving the C2-C3 dermatomes can provoke postherpetic neuralgia, characterized by severe, burning pain along the affected sensory territories of the cervical plexus, often requiring targeted interventions for relief. Diagnosis of cervical plexus injuries relies on electromyography (EMG) to assess motor deficits, such as in the infrahyoid or phrenic-innervated muscles, and nerve conduction studies to quantify sensory loss in branches like the great auricular nerve. Magnetic resonance imaging (MRI) is essential for visualizing the plexus's relations to surrounding structures, identifying compressive pathology or traumatic disruptions, and guiding therapeutic decisions.

Anesthetic Blocks and Surgical Relevance

The cervical plexus serves as a key target for regional anesthesia in neck procedures, enabling targeted nerve blocks that provide analgesia while minimizing systemic effects of general anesthesia. Superficial cervical plexus blocks, which anesthetize the cutaneous branches emerging from the posterior border of the sternocleidomastoid muscle, are commonly employed for superficial surgeries such as lymph node biopsies or clavicular procedures. These blocks can be performed using landmark-based techniques, involving needle insertion at the midpoint between the mastoid process and the hyoid bone, or ultrasound-guided approaches for enhanced precision. Ultrasound guidance typically employs an in-plane needle trajectory targeting the posterior sternocleidomastoid border, where 5 to 15 mL of local anesthetic is deposited in the fascial plane superficial to the prevertebral fascia to block the lesser occipital, great auricular, transverse cervical, and supraclavicular nerves. Deep cervical plexus blocks, in contrast, involve injection deeper to the prevertebral fascia at the C2-C4 transverse processes, providing anesthesia for procedures involving deeper neck structures like thyroidectomy or carotid endarterectomy, often requiring similar volumes but with greater caution due to proximity to vital structures. Historically, cervical plexus blocks were first described in the early 20th century for regional anesthesia, with a posterior approach outlined by Kappis in 1912 and a lateral approach by Heidenhain in 1914, later refined by Pauchet in 1920 to improve safety and efficacy. These techniques have evolved into standard practice for awake carotid endarterectomy, where combined superficial and deep blocks allow patient cooperation during surgery while reducing hemodynamic instability compared to general anesthesia. In thyroidectomy, deep blocks facilitate analgesia for procedures accessing the anterior neck, often combined with superficial blocks to cover both dermal and deeper innervation. In surgical contexts, precise identification of the cervical plexus during neck dissections is essential to prevent iatrogenic injury, particularly when resecting lymphatic tissues in radical or modified procedures where the sensory branches and phrenic nerve course through the operative field. Surgeons must visualize the plexus emerging between the scalene muscles and preserve its rami to avoid sensory deficits or motor impairments, with the phrenic nerve specifically protected during thoracic inlet exposures to mitigate risks of respiratory compromise from diaphragmatic paralysis. Complications of cervical plexus blocks, though infrequent with superficial techniques, include phrenic nerve palsy leading to hemidiaphragmatic paralysis, with risks reported as low as 13% in ultrasound-guided approaches but potentially higher (up to 60%) in deeper or landmark-based methods due to local anesthetic spread. This palsy can cause transient ventilatory reduction, particularly in patients with preexisting pulmonary disease, emphasizing the need for preoperative respiratory assessment and preference for superficial blocks when feasible.

Anatomical Variations

Types of Variations

The cervical plexus exhibits several loop variations, particularly involving the ansa cervicalis. The superior root of the ansa cervicalis, typically arising from C1 via the hypoglossal nerve, may be absent in approximately 2.5% of cases, resulting in direct contributions from C1 or alternative pathways such as a vagocervical plexus formed by the vagus nerve and C1-C2 ventral rami to innervate infrahyoid muscles. Additionally, extra loops or prefixed formations can occur, such as contributions from C5 in rare instances, altering the standard C1-C4 loop structure. Branch anomalies are also common among cervical plexus derivatives. The great auricular nerve, normally formed by C2 and C3, receives considerably more fibers from C2. Supraclavicular nerves occasionally feature atypical branching patterns, which can extend innervation over the anterior chest. The phrenic nerve, primarily from C4, shows variations such as origin solely from C4 in common cases or extended to C3-C6 in prefixed or postfixed plexuses, with accessory contributions from C5 present in 61.8-75% of cadavers. Communication variants include anastomoses between cervical plexus branches and adjacent nerves. For instance, the lesser occipital nerve may occasionally branch from the greater occipital nerve (from C2 dorsal ramus) instead of the standard cervical loop, potentially augmenting sensory supply to the scalp. Absent descendens hypoglossi (a C1 branch via hypoglossal) with direct C1 integration into the ansa cervicalis is noted as a variation, bypassing the typical pathway. Cadaveric studies indicate that variations in cervical plexus structure are common, encompassing these loop, branch, and communication anomalies, underscoring the need for awareness in anatomical dissections.

Clinical Implications of Variations

Anatomical variations in the cervical plexus can significantly elevate surgical risks during neck procedures. For instance, phrenic nerve injury during scalenectomy for thoracic outlet syndrome can lead to diaphragmatic paralysis and respiratory complications. Similarly, variant trajectories of the great auricular nerve, such as atypical branching or deeper positioning within the parotid gland, complicate parotidectomy and increase the incidence of postoperative auricular numbness or hypoesthesia, affecting 26-59% of cases without nerve preservation. These variations also pose diagnostic challenges by altering sensory distributions and mimicking other neuropathies. Atypical dermatomes from variant lesser occipital or transverse cervical nerves may result in referred pain patterns that resemble trigeminal neuralgia or occipital neuralgia, complicating accurate attribution of symptoms in cervicogenic headaches. Preoperative imaging, such as CT or MRI, is essential to identify these variants and guide differential diagnosis, preventing misattribution of pain sources. Therapeutic approaches require adjustments to accommodate plexus variations for optimal outcomes. In cases of absent or hypoplastic ansa cervicalis loops, anesthetic blocks may necessitate modified techniques, including ultrasound guidance and increased local anesthetic volumes to ensure coverage of variant pathways, thereby enhancing efficacy in regional anesthesia for thyroidectomy or carotid endarterectomy. Epidemiologically, variations in cervical plexus structures can impact regional anesthesia success rates, underscoring the need for tailored preoperative assessments.

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