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Combitube

The Combitube, also known as the Esophageal Tracheal Combitube (ETC), is a disposable, dual-lumen supraglottic airway device designed for rapid emergency insertion to secure ventilation in patients with difficult or compromised airways, particularly when traditional endotracheal intubation is not feasible.^[1] It features a single outer tube with an internal partition creating two lumens—one for primary esophageal ventilation with side holes in the pharyngeal section, and another for potential tracheal use—along with proximal oropharyngeal and distal esophageal/tracheal balloons that inflate to create seals and prevent aspiration or air leakage.^[1] The device allows blind insertion without laryngoscopy, typically entering the esophagus in about 95% of cases, where ventilation occurs through the pharyngeal holes while the distal lumen decompresses the stomach.^[1] Developed starting in 1981 by Austrian anesthesiologist Michael Frass, engineer Jonas Zahler, and anesthesiologist Reinhard Frenzer at the Medical University of Vienna to address gaps in prehospital airway management, the Combitube was patented in 1987 and entered commercial production in 1988 by Sheridan Catheter Corporation (later acquired by Tyco Healthcare, now part of Medtronic via Covidien).^[2]^[3] It gained widespread adoption in emergency medical services (EMS) worldwide for its simplicity and high success rate in non-surgical settings, serving as a bridge between basic maneuvers like bag-valve-mask ventilation and advanced techniques.^[1] Over three decades of use, it has been particularly valued in out-of-hospital cardiac arrests, trauma, and "cannot intubate, cannot ventilate" scenarios, with studies confirming its effectiveness as a salvage airway in paramedic rapid sequence intubation protocols.^[4]^[5] While its use has declined in favor of newer supraglottic devices as of 2025, it remains available and effective in specific emergency contexts. Key indications include supraglottic obstructions, maxillofacial or cervical spine injuries, and situations requiring immediate oxygenation without visualization, though it is not intended as a long-term solution and requires confirmation of placement via capnography or auscultation.^[1] While complications such as esophageal trauma or regurgitation can occur, clinical reviews highlight its reliability in high-acuity environments, influencing the evolution of later supraglottic devices such as the Laryngeal Tube and King LT.^[5]

History and Development

Invention

The Combitube, also known as the esophageal tracheal Combitube (ETC), was invented in the early 1980s by Michael Frass, Jonas Zahler, and Reinhard Frenzer at the Medical University of Vienna.^[2] The primary motivation was to create a reliable emergency airway device for prehospital and cardiopulmonary resuscitation (CPR) scenarios, where traditional endotracheal intubation often required skilled personnel, specialized equipment like a laryngoscope, and optimal patient positioning—conditions frequently unavailable in the field.^[2] This design addressed limitations of existing alternatives, such as the bag-valve-mask (which risked gastric insufflation and aspiration) and the esophageal obturator airway (which had ventilation inconsistencies), by enabling blind oral insertion and effective ventilation regardless of placement.^[2] Development began in 1981 when Frass and Zahler initiated the concept, with Frenzer joining in 1983 to refine the prototype.^[2] The core innovation was a dual-lumen structure: a longer esophageal lumen for gastric drainage and ventilation via a shorter tracheal lumen when misplaced, or direct tracheal ventilation when correctly placed, sealed by pharyngeal and esophageal balloons to prevent air leaks.^[2] Initial testing focused on functionality in animal models to assess ventilation efficacy during CPR simulations, confirming the device's ability to maintain oxygenation in both placement scenarios.^[6] The first formal publication on the Combitube appeared in 1987, authored by Frass and colleagues, detailing preliminary results from cadaver and early human trials that demonstrated comparable arterial oxygenation to endotracheal intubation during CPR.^[7] A related study that year further evaluated its use in resuscitation, reporting successful ventilation in animal and human subjects.^[8] In 1987, the inventors received U.S. Patent No. 4,688,568 for the device.^[9] Commercial production commenced in 1988 under Sheridan Catheter Corporation, later acquired by Tyco Healthcare (now part of Medtronic), with Frass retaining patent rights and receiving royalties.^[2]^[10]

Clinical Introduction and Evolution

The first human uses and clinical trials of the Combitube occurred in 1988, with initial evaluations demonstrating its effectiveness in cardiopulmonary resuscitation (CPR) scenarios, achieving successful ventilation in the majority of cases through esophageal placement and comparable blood gas results to endotracheal intubation.^[11] Published in the Chest journal, these early studies highlighted the device's prompt insertion, with mean times around 18 seconds in applicable patients, and underscored its potential as a blind-insertion alternative for emergency airway management during cardiac arrest.^[12] The Combitube received FDA approval in the United States in 1985 as a Class II medical device specifically for emergency airway management, marking its formal entry into clinical practice and enabling widespread adoption in prehospital and hospital settings.^[13] Subsequent evolution included the introduction of the Small Adult Combitube version in 1997, designed for patients shorter than 155 cm to improve fit and reduce complications in smaller adults, expanding its applicability beyond the standard size.^[14] Manufacturer transitions shaped its ongoing development, beginning with Sheridan Catheter Corp. and moving to Tyco Healthcare in the late 1990s, followed by the spin-off to Covidien in 2007 and acquisition by Medtronic in 2015, during which updates emphasized single-use disposable materials to minimize infection risks associated with reuse. By the 2010s, the Combitube's prominence declined with the rise of video laryngoscopy and newer supraglottic airway devices offering improved visualization and success rates, though it remains incorporated in some emergency medical services (EMS) protocols for difficult airways.

Design and Specifications

Components

The Combitube features a dual-lumen design constructed from polyvinyl chloride (PVC), making it latex-free for use in emergency airway management.^[15]^[6] The primary lumen, which is the larger blue tube (numbered #1), is intended for esophageal placement; its distal end is sealed, but it includes eight perforations located between the two cuffs to allow ventilation into the pharynx and oxygenation when the device is positioned in the esophagus.^[6]^[16] The secondary lumen, a smaller clear or transparent tube (numbered #2), has an open distal end for direct tracheal ventilation if the device is inadvertently placed in the trachea, and it also permits gastric suctioning via a compatible catheter in cases of esophageal intubation.^[6]^[16] The device incorporates two inflatable cuffs to secure its position and prevent aspiration. The proximal pharyngeal cuff, a larger balloon located in the midsection, seals the oropharynx and is inflated with approximately 85 mL of air for the 37 Fr size or 100 mL for the 41 Fr size using a blue pilot balloon connected to syringe port #1.^[6]^[17] The distal cuff, positioned at the lower end, seals the esophagus (or trachea if misplaced) and requires about 10–15 mL of air for inflation via a white pilot balloon at syringe port #2.^[6]^[16] These ports are color-coded for quick identification: blue for the pharyngeal cuff and white for the distal cuff.^[6] Both lumens terminate at the proximal end with standard 15-mm universal connectors angled for easy attachment to a bag-valve-mask system.^[15] Additionally, the Combitube includes radiopaque lines along its length to facilitate radiographic confirmation of placement.^[15] Black alignment rings on the external surface aid in determining proper insertion depth relative to the teeth.^[17]

Available Sizes

The Combitube is available in two primary sizes designed for adult patients, differentiated by external diameter in French gauge (Fr) units and tailored to body height to ensure proper fit and sealing. The standard adult size, designated 41 Fr, is intended for patients taller than 152 cm (5 feet). This model features a pharyngeal (oropharyngeal) cuff with a maximum inflation volume of 100 ml and a distal cuff volume of 15 ml. The small adult size, 37 Fr, accommodates patients between 122 cm and 168 cm (4 feet to 5 feet 6 inches) in height, such as smaller women or elderly individuals, with a pharyngeal cuff volume of 85 ml and a distal cuff volume of 12 ml. No dedicated pediatric sizes are available; the 37 Fr small adult size is suitable for children taller than 122 cm (4 feet).^[17]^[18]^[16] These sizes reflect the device's double-lumen construction, where the external diameter influences overall compatibility with patient anatomy, while cuff volumes ensure occlusion of the esophagus or trachea depending on placement. The 41 Fr model's larger dimensions provide robust sealing for taller patients, whereas the 37 Fr variant offers a more proportionate fit for shorter statures to minimize tissue trauma. Both sizes include color-coded lumens: the longer blue lumen (#1) for primary esophageal placement and ventilation via pharyngeal perforations, and the shorter clear lumen (#2) for potential tracheal ventilation or gastric suction.^[17] All Combitube models are single-use and supplied sterile to prevent cross-contamination, packaged in trays or roll-up kits that include a 140 ml syringe for pharyngeal cuff inflation, a 20 ml syringe for the distal cuff, and a suction catheter for gastric decompression. They feature a universal 15 mm connector at the proximal end for compatibility with standard ventilators, Ambu bags, or other respiratory equipment.^[17]^[19]

Indications and Contraindications

Primary Indications

The Combitube is primarily indicated for securing the airway in emergency prehospital settings involving unconscious patients without a gag reflex, such as those experiencing cardiac arrest or trauma where rapid airway management is essential to facilitate ventilation and oxygenation.^[1] In these scenarios, its blind insertion capability allows for quick deployment by emergency medical services personnel at accident sites or during transport, particularly when patient access is restricted.^[1] It serves as a key tool in difficult airway situations, including cases of failed orotracheal intubation attempts or limited access due to factors like cervical spine immobilization in trauma patients.^[1] The device is recommended when conventional intubation is challenging or impossible, such as in "cannot intubate, cannot ventilate" emergencies, providing an effective rescue option to maintain oxygenation.^[1] During cardiopulmonary resuscitation (CPR), the Combitube enables blind insertion and effective ventilation without interrupting chest compressions, aligning with American Heart Association (AHA) guidelines for advanced providers in cardiac arrest management.^[20] Supraglottic airways are considered an acceptable alternative to endotracheal intubation (Class 2b recommendation in 2020 AHA guidelines), allowing for 10 breaths per minute while compressions continue at 100-120 per minute.^[21]^[22] In resource-limited environments, such as disaster response or military field medicine, the Combitube supports short-term anesthesia and airway control for unconscious or paralyzed patients, where advanced equipment may be unavailable.^[23] Its simplicity makes it suitable for use by combat medics or in austere settings requiring rapid intervention.^[24] The device is particularly indicated for adults and small adults in out-of-hospital cardiac arrest, with esophageal placement success rates exceeding 95%, enabling reliable ventilation even if tracheal positioning is not achieved.^[1]

Contraindications

The Combitube is contraindicated in patients with an intact gag reflex, as insertion may provoke vomiting and aspiration.^[1]^[25] Known or suspected esophageal pathology represents an absolute contraindication, including conditions such as strictures, tumors, varices, diverticula, or recent esophageal or gastric surgery, due to the risk of perforation or exacerbation of the underlying disease.^[25]^[26] Ingestion of caustic substances is also an absolute contraindication, as it may lead to esophageal damage that complicates safe placement and increases the risk of rupture.^[25]^[26] Suspected upper airway obstruction or laryngectomy further prohibits use, as the device's design assumes a patent esophageal or tracheal pathway for proper positioning.^[1] Relative contraindications include patients with heights under 4 feet (122 cm) or over 6 feet 6 inches (198 cm), owing to anatomical mismatch with available sizes that may prevent secure fit or effective sealing.^[25]^[1] The device is not indicated for pediatric patients under approximately 48 inches (122 cm) in height, as no suitable sizes exist and anatomical proportions differ significantly.^[1] Prolonged ventilation exceeding 8 hours is relatively contraindicated due to risks of pharyngeal mucosal ischemia from cuff pressure.^[25] Pre-insertion assessment should screen for history of caustic ingestion or esophageal abnormalities to avoid misplacement, and the device is generally avoided in awake or responsive patients where alternatives like endotracheal intubation are feasible.^[25]^[1]

Insertion and Use

Procedure Steps

The insertion of the Combitube, an esophageal-tracheal double-lumen airway device, follows a standardized blind technique to establish ventilation in emergency settings where traditional intubation is challenging.^[27] Preparation: Position the patient supine on a firm surface. If cervical spine injury is not suspected, extend the head into the sniffing position by elevating the occiput with towels or padding to align the oral, pharyngeal, and tracheal axes. Select the appropriate size—37 Fr for patients 122–168 cm (4' to 5'6") tall or 41 Fr for those ≥170 cm (5'7") tall—and test both cuffs for leaks by inflating and deflating them. Lubricate the distal tip and outer surface of the deflated device with sterile, water-soluble lubricant to facilitate smooth passage. Ensure suction equipment is immediately available to manage potential secretions or regurgitation.^[27]^[17] Insertion: Open the patient's mouth using a jaw-thrust or chin-lift maneuver while maintaining inline stabilization if cervical injury is possible. Grasp the tongue and lower jaw with the non-dominant hand to displace the tongue forward. With the dominant hand, insert the Combitube blindly into the midline of the oropharynx, directing it posteriorly along the natural curve of the pharynx toward the esophagus; avoid using force or a laryngoscope. Advance the tube gently until the two black ring marks straddle the upper teeth or alveolar ridge, ensuring proper depth without over-insertion.^[27]^[28]^[17] Cuff Inflation: First, inflate the proximal pharyngeal cuff (connected via the blue pilot balloon, Line 1) with 85 mL of air for the 37 Fr size or 100 mL for the 41 Fr size using a large-volume syringe, or until a seal is achieved without audible leak during a test ventilation. Then, inflate the distal cuff (connected via the white pilot balloon, Line 2) with 12 mL of air for the 37 Fr size or 15 mL for the 41 Fr size using a small syringe to occlude the distal airway.^[17]^[16] Initial Ventilation: Attach a bag-valve-mask or ventilator to the primary lumen (longer blue tube, No. 1), which assumes esophageal placement, and deliver initial breaths at 8–10 per minute with 500–800 mL tidal volume. Observe for chest rise; if absent or epigastric distension occurs, immediately deflate both cuffs, withdraw the tube 1–2 cm, and reattempt insertion, or switch to ventilating through the secondary lumen (shorter clear tube, No. 2) for presumed tracheal placement. The dual-lumen design allows this switch without removal.^[27]^[17] Securing: Once effective ventilation is established, secure the tube in place using adhesive tape, a commercial holder, or ties around the head to prevent dislodgement. Continuously monitor for tube migration, especially during patient transport or movement.^[27]^[28]

Ventilation and Confirmation

Following insertion of the Combitube, proper placement must be verified to ensure effective ventilation. Initial confirmation involves auscultation of bilateral breath sounds over the lung fields and absence of epigastric sounds to distinguish tracheal from esophageal positioning, though auscultation can be challenging due to the device's design.^[27] A colorimetric carbon dioxide detector attached to the ventilation lumen provides reliable verification: a color change from yellow to purple indicates tracheal placement with exhaled CO2 detection, while no change suggests esophageal placement.^[29] In approximately 95% of cases, the Combitube distal tip enters the esophagus, allowing ventilation through the primary lumen (numbered #1, typically marked blue) via multiple pharyngeal perforations proximal to the distal cuff, which directs airflow to the trachea while the blind-ended secondary lumen (#2) seals the esophagus.^[27] In the rarer tracheal placement (about 5%), ventilation occurs directly through the secondary lumen (#2) as with a conventional endotracheal tube, bypassing the pharyngeal ports.^[16] Ventilation is performed using a bag-valve device at 8-10 breaths per minute, with tidal volumes of approximately 500 mL per breath lasting about 1 second.^[27] Ongoing monitoring includes continuous waveform capnography if available to track end-tidal CO2 levels and confirm sustained tracheal patency, alongside observation of symmetric chest rise and pulse oximetry.^[27] A chest X-ray serves as definitive confirmation, visualizing the distal tip in the trachea for tracheal placement or in the esophagus for esophageal placement.^[1] For gastric decompression in esophageal placement, a nasogastric tube can be inserted through the primary lumen to aspirate contents and reduce aspiration risk.^[27] The Combitube should be removed once a definitive airway, such as an endotracheal tube, can be secured by appropriately trained personnel, or if complications occur; it is not intended for prolonged use beyond several hours.^[27] Removal involves deflating the pharyngeal (proximal) cuff first, followed by the distal cuff, then gently withdrawing the device while maintaining oxygenation, often with suction ready to manage any secretions.^[30]

Complications and Management

Common Complications

One of the most frequent complications associated with the Combitube is sore throat, occurring in 39-48% of patients due to the pressure from the inflated pharyngeal cuff on the oropharyngeal structures.^[31]^[32] This discomfort typically manifests postoperatively and is often accompanied by dysphagia, reported in up to 68% of cases from similar mucosal irritation.^[32] These symptoms generally resolve within several days with conservative management, including oral analgesics, hydration, and avoidance of irritants, though severe cases may persist longer.^[33] Upper airway hematoma or mucosal lacerations arise from mechanical trauma during blind insertion, with evidence of blood on the device noted in approximately 31% of uses and overt hematoma in up to 36% in smaller cohorts.^[31]^[32] Patients should be monitored for signs of swelling or airway compromise, managed with ice application, anti-inflammatory analgesics, and observation; most resolve without intervention within days.^[33] Vomiting or regurgitation poses a risk particularly in semi-conscious patients during insertion, potentially leading to aspiration if not addressed promptly.^[27] Preemptive suctioning of oropharyngeal contents and immediate inflation of the cuffs upon placement minimize this risk by sealing the airway.^[27] Overinflation of the cuffs, if exceeding manufacturer recommendations (typically 85-100 mL for the pharyngeal cuff and 10-15 mL for the distal cuff), can cause local ischemia by impairing mucosal perfusion, with symptoms such as persistent hoarseness or tongue cyanosis observed in 12-17% of cases.^[1]^[31] Adhering to specified volumes and monitoring cuff pressure when possible prevents these issues, which usually abate upon deflation.^[1] Overall, minor complications occur in 20-40% of Combitube insertions, a rate higher than with endotracheal tubes in short-term applications, as evidenced by comparative studies showing elevated pharyngeal trauma.^[32]^[34]

Rare but Serious Risks

Although esophageal perforation is a rare complication of Combitube insertion, with an incidence of less than 1% (approximately 0.7% in a prehospital series of 280 patients), it is more likely to occur in patients with preexisting esophageal pathology or trauma.^[34] This injury typically presents with severe neck or chest pain, subcutaneous emphysema, and signs of mediastinitis, necessitating immediate surgical consultation, broad-spectrum antibiotics, and potential endoscopic or operative repair.^[35]^[36] Aspiration pneumonia associated with the Combitube occurs in up to 11% of prehospital cases, often due to device misplacement allowing regurgitation or gastric contents to enter the airway.^[34] Prevention strategies include applying cricoid pressure during insertion, while management involves patient positioning to facilitate drainage, aggressive suctioning, and supportive antibiotics if infection develops.^[34] Cranial nerve dysfunction, such as transient vocal cord paralysis or hypoglossal nerve palsy, represents a rare neuropraxia potentially caused by prolonged cuff pressure or pharyngeal trauma during Combitube use.^[37] These injuries typically manifest as dysphonia, dysphagia, or tongue deviation postoperatively and are managed through neurological monitoring, with most cases resolving spontaneously within weeks without long-term intervention.^[37] Pneumothorax may arise infrequently (around 2% incidence in prehospital use) from high-pressure ventilation if the Combitube is inadvertently placed in the trachea, leading to barotrauma.^[34] Diagnosis relies on clinical auscultation for absent breath sounds and confirmation via chest X-ray, with treatment involving immediate decompression via needle thoracostomy or chest tube insertion if tension physiology is present.^[34] Esophageal rupture has been reported in cases from the late 1990s following Combitube use, often requiring endoscopic dilation or surgical management if long-term complications develop.^[36] While complications persist, the device's use has decreased with advancements in airway management as of 2023.^[31]

Comparisons with Other Airway Devices

Versus Endotracheal Tube

The Combitube offers advantages in insertion speed and success rates compared to the standard endotracheal tube (ETT), particularly in emergency settings or among less experienced providers. Blind insertion of the Combitube typically achieves airway securing in 15-40 seconds with first-attempt success rates of 90-100%, even for novices after brief training.^[38]^[39] In contrast, ETT placement requires laryngoscopy and often takes 30-90 seconds, with first-attempt success rates of 70-90% in skilled hands, dropping lower for paramedics or emergency medical staff without extensive practice.^[38]^[40] These differences make the Combitube a faster alternative for rapid airway management in out-of-hospital cardiac arrest or trauma scenarios.^[41] Regarding protection against aspiration, the ETT provides superior sealing via its cuff positioned below the vocal cords, minimizing regurgitation risk during positive pressure ventilation.^[42] The Combitube relies on its pharyngeal balloon and esophageal cuff for gastric decompression and partial barrier function, but studies indicate a higher potential for regurgitation and aspiration compared to ETT, though it still reduces risk relative to basic airways.^[1]^[43] Training requirements for the Combitube are minimal, often limited to 1-2 hours of instruction for emergency medical services personnel, enabling high success among paramedics and nurses without advanced intubation expertise.^[44] ETT insertion, however, demands specialized laryngoscopy skills and ongoing simulation practice, typically reserved for anesthesiologists or highly trained intensivists.^[45] The Combitube is intended for short-term use, generally under 2 hours as an interim device before definitive airway placement, due to concerns over prolonged cuff pressure and tissue trauma.^[25] In comparison, the ETT supports extended mechanical ventilation for hours or days in intensive care settings.^[6] Cost-wise, the disposable Combitube unit ranges from $50-80, including necessary syringes and adapters, while a basic ETT tube costs $3-10 but requires additional equipment like a laryngoscope ($200-500) and blades, increasing overall setup expenses.^[46]^[47]

Versus Supraglottic Devices

The Combitube, a dual-lumen esophageal-tracheal supraglottic airway device, differs in anatomical positioning and mechanism of action from other supraglottic devices like the laryngeal mask airway (LMA). While the LMA creates a supraglottic seal above the glottis to facilitate ventilation without entering the trachea or esophagus, the Combitube is designed for blind insertion that typically results in esophageal placement (about 95% of cases), with ventilation directed through a distal tracheal lumen or, less commonly, reversed if tracheal placement occurs. This invasive dual-path approach allows the Combitube to provide effective airway management in scenarios where visualization is challenging, such as during cardiopulmonary resuscitation (CPR), where it can be inserted with minimal interruption to chest compressions, unlike some supraglottic devices that may require head repositioning.^[44]^[48] In terms of success rates for difficult airways, particularly in trauma settings, the Combitube demonstrates high efficacy, with insertion success reaching 95.1% as a salvage device following failed orotracheal intubation in prehospital trauma patients. Comparatively, the LMA achieves success rates of 85-90% in difficult airway scenarios, though it can drop to as low as 50% among less experienced emergency medical technicians. However, the LMA generally allows for faster placement, with median insertion times of 40 seconds in unskilled hands versus 45 seconds for the Combitube, and even quicker in manikin simulations (5-6 seconds for both, with LMA slightly slower for novices); this speed advantage makes the LMA less traumatic overall during insertion.^[4]^[49]^[50]^[38] Regarding gastric access and aspiration risk, the Combitube's esophageal positioning enables direct drainage through its proximal lumen, preventing gastric insufflation and aspiration in up to 93% of cases, offering superior protection compared to standard LMAs, which provide limited safeguards against regurgitation. Certain LMA variants, such as the ProSeal, include a dedicated gastric tube port for drainage, but this is less comprehensive than the Combitube's built-in esophageal venting. Both devices are suitable for short-term anesthesia, yet the Combitube is particularly favored in cardiac arrest situations due to its robust aspiration barrier and reliability in low-flow environments.^[44]^[51] The complication profile of the Combitube includes a higher incidence of soft tissue injuries, such as pharyngeal trauma (10-20% in some reports), compared to the LMA's lower rate (around 5%, primarily sore throat or minor leaks). Studies from the 2010s, including manikin-based trials, indicate similar oxygenation and ventilation efficacy between the two devices in emergency settings, with both achieving near-100% success in skilled hands; however, the Combitube shows superiority in low-skill or inexperienced users due to its forgiving design, which permits ventilation regardless of exact placement.^[52]^[38]^[50] The Combitube has influenced later supraglottic devices such as the King LT, which features a single inflation port for both cuffs and a simpler design. Studies show the King LT achieves faster insertion times (around 24 seconds versus 38 seconds for the Combitube) and is perceived as easier to use by flight crews and paramedics, with similar high success rates (96-100%), though both devices carry risks of soft tissue injury. The King LT has largely replaced the Combitube in some EMS protocols due to these advantages.^[39]^[53]

Current Status and Guidelines

Evidence from Studies

Early clinical trials by Frass and colleagues from 1988 to 1995 established the Combitube's efficacy for emergency ventilation during CPR. In a 1988 study involving 50 patients, the device provided effective ventilation with blood gas analyses comparable to endotracheal intubation, achieving success in all applicable cases.^[54] A 1993 prospective study further demonstrated that ICU nurses achieved successful intubation and ventilation with the Combitube in CPR scenarios at rates equivalent to endotracheal intubation by intensivists, with high reliability across over 100 patients.^[55] Prehospital studies in the 2000s highlighted the Combitube's utility in emergency medical services for cardiac arrest. A 2000 multicenter trial involving EMT-defibrillation providers reported successful airway placement in 92% of 195 cardiorespiratory arrest cases, enabling effective ventilation without significant delays.^[56] Similarly, a 2002 study across 831 adult cardiac arrest patients showed a 95.4% insertion success rate, with outcomes supporting its role in out-of-hospital settings comparable to advanced airways.^[57] These findings indicated improved survival to hospital admission in select EMS cohorts using the Combitube versus basic bag-mask ventilation, though direct comparative survival data varied by protocol. Research focused on complications has identified risks associated with Combitube use, particularly in prehospital environments. A 2007 retrospective analysis of 281 cases reported serious adverse events, such as esophageal perforation and upper airway trauma, in 4.3% of instances, with higher rates linked to esophageal pathology or difficult insertions.^[34] A 2003 literature review synthesized over 200 reported cases, noting an overall incidence of major complications around 8%, including pneumomediastinum and nerve injuries, emphasizing the need for careful patient selection.^[58] Comparative randomized controlled trials have evaluated the Combitube against endotracheal intubation, especially among novices. A 2015 manikin-based RCT involving inexperienced emergency staff found the Combitube achieved 100% airway success versus 73% for endotracheal intubation (p=0.0001), with significantly faster insertion times (median 5 seconds versus longer for endotracheal tube) while maintaining equivalent oxygenation levels.^[38] Recent meta-analyses of supraglottic airway devices, including the Combitube, in out-of-hospital cardiac arrest have shown benefits in procedural efficiency but limited impact on outcomes. A 2024 systematic review and meta-analysis indicated that supraglottic devices reduce no-flow time during CPR compared to endotracheal intubation by minimizing interruptions for placement, yet they confer no significant mortality benefit over alternatives like bag-mask ventilation, with pooled short-term survival odds ratios near 1.0.^[59]

Recommendations in Practice

The American Heart Association (AHA) 2025 guidelines position supraglottic airway devices (SGAs), including legacy devices like the Combitube, as viable alternatives to endotracheal intubation for airway management during cardiac arrest when performed by trained providers, particularly after failed basic ventilation attempts or in systems with low intubation success rates.^[60] These guidelines recommend assessing and considering placement of an advanced airway device, such as an endotracheal tube or supraglottic device, with confirmation via waveform capnography to verify placement and monitor end-tidal CO2.^[60] The European Resuscitation Council (ERC) 2025 guidelines similarly endorse SGAs as a second-line option following bag-mask ventilation during cardiac arrest, with a preference for the i-gel over laryngeal tubes when using an SGA.^[61] The Combitube is not explicitly prioritized over newer SGAs, and permanent end-tidal CO2 measurement is mandatory for verification.^[61] The National Association of EMS Physicians (NAEMSP) 2022 position statement on prehospital supraglottic airways endorses SGAs, such as the Combitube, for use in emergency medical services (EMS) during difficult or failed airways, emphasizing their role in providing oxygenation and ventilation while minimizing interruptions in chest compressions.^[62] NAEMSP advocates for agency-specific protocols that include SGA deployment after unsuccessful intubation attempts, with training requirements ensuring providers achieve proficiency through supervised simulations and a minimum of 10 successful insertions on manikins prior to independent use.^[62] Annual recertification via high-fidelity simulation is recommended to maintain skills, focusing on placement verification techniques like auscultation, chest rise observation, and capnography.^[62] Despite these endorsements, the Combitube faces limitations in contemporary protocols; it is not considered first-line in hospital settings equipped with video laryngoscopes, where direct visualization techniques are preferred for superior success rates in non-arrest scenarios.^[26] Manufacturer discontinuation of the Combitube has restricted its availability, though it remains in use in some EMS systems as of 2025, prompting transitions to updated alternatives.^[63] Looking ahead, integration of capnography is now mandatory in major guidelines for all advanced airway confirmations, including legacy SGAs like the Combitube where still in use, to reduce unrecognized malposition.^[60]

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[PDF] esophageal-tracheal
The Combitube comes in two sizes: Combitube 37 F SA (=small adult), and Combitube 41 F. Table 1: Combitube sizes: Description. Combitube SA 37 F. Combitube 41 F.Missing: dimensions | Show results with:dimensions
[19]
Contemporary issues in pediatric prehospital airway management
Sep 22, 2025 · Contemporary examples of SGA include the Combitube (Medtronic ... Evidence guiding prehospital pediatric airway management practices is limited.
[20]
[PDF] Combitube Placement
Aug 1, 2017 · Greater than 4 feet in height for small adult (SA) size or greater than five feet tall for regular size. CONTRAINDICATIONS:.
[21]
Part 7.1: Adjuncts for Airway Control and Ventilation | Circulation
Nov 28, 2005 · Indications for emergency endotracheal intubation are (1) the inability of the rescuer to adequately ventilate the unconscious patient with a ...<|separator|>
[22]
Feasibility of Supraglottic Airway Use by Combat Lifesavers on the ...
Nov 1, 2013 · Current doctrine restricts all supraglottic airway use to the Combat Medic or Combat Paramedic provider levels.7 The Combitube device requires a ...
[23]
Combitube Dual-lumen Esophageal Airway Device Retention Skills ...
Aug 9, 2025 · Combitube Dual-lumen Esophageal Airway Device Retention Skills in Deployed Army Combat Medics. May 2005; Academic Emergency Medicine 12 ...
[24]
Esophageal-Tracheal Double-Lumen Airways: The Combitube and ...
Apr 12, 2017 · Use of the Combitube is indicated in routine surgery in patients for whom conventional intubation is not mandatory, such as singers and actors ...
[25]
Current Extraglottic Airway Devices and Prehospital Practices | Page 2
Nov 8, 2024 · The Combitube is contraindicated in patients with upper esophageal abnormalities, such as esophageal varices, or caustic ingestions.11 As ...
[26]
How To Insert an Esophageal-Tracheal Double Lumen Tube ...
The balloon cuffs of the Combitube are inflated individually. · An estimated 1 to 5% of Combitube insertions enter the trachea; in these cases, if the ...Missing: specifications | Show results with:specifications
[27]
1: Combitube Insertion and Removal - Clinical Gate
Mar 6, 2015 · Proximal cuff (85 mL or 100 mL, depending on tube size) to occlude the hypopharynx · Distal cuff (12 mL or 15 mL, depending on tube size) to ...Missing: diameter length
[28]
Combined use of the esophageal-tracheal Combitube with a ...
The purpose of this study was to determine if the Easycap can be used to identify which Combitube lumen is patent to the trachea after blind placement in dogs.Missing: CO2 confirmation
[29]
[PDF] C:\My Documents\WordPerfect\EMS\Combitube monograph.wpd
Do NOT use the Esophageal Detector Device (Bulb) with the Combitube. Identifying the location of the tube is the most critical step in the use of the Combitube.
[30]
Ventilation with the esophageal-tracheal Combitube during general ...
Apr 21, 2023 · The esophageal-tracheal Combitube (ETC) was developed for the management of difficult airways but can also be used for general anaesthesia.Missing: 1986 | Show results with:1986
[31]
Complications Following the Use of the Combitube, Tracheal Tube ...
Insertion of the Combitube was associated with a higher incidence of sore throat (48% vs. 16% vs. 12% [p < 0.01]) and dysphagia (68% vs. 12% vs. 8% [p < 0.01])Missing: meta- analysis
[32]
Complications Associated with the Use of Supraglottic Airway ... - PMC
This review highlights the types and incidence of these complications. They include regurgitation and aspiration of gastric contents, compression of vascular ...
[33]
Complications associated with the Esophageal-Tracheal Combitube ...
The objective of this retrospective study was to determine the incidence and the nature of complications associated to the Combitube in the pre-hospital setting ...Missing: throat dysphagia meta-
[34]
Piriform sinus perforation during Esophageal-Tracheal Combitube ...
... Combitube placement by prehospita … ... MeSH terms. Aged; Angioedema / complications*; Emergency Medical Services; Esophageal Perforation / etiology* ...
[35]
Esophageal rupture associated with the use of the Combitube
Esophageal rupture associated with the use of the Combitube. Anesth Analg. 1998 Dec;87(6):1457. doi: 10.1097/00000539-199812000-00059.
[36]
Combitube rescue for Cesarean delivery followed by ninth ... - PubMed
Combitube rescue for Cesarean delivery followed by ninth and twelfth cranial nerve dysfunction. Can J Anaesth. 2008 Nov;55(11):779-84. doi: 10.1007 ...
[37]
Comparison of endotracheal intubation, combitube, and laryngeal ...
The median time to Combitube placement in experienced and inexperienced was 5.05 vs. 5.00 seconds, P = 0.65, respectively. Inexperienced and experienced groups ...
[38]
The King LT versus the Combitube: flight crew performance and ...
Mean time to placement was 24.4 seconds (standard deviation [SD] of 4.7 seconds) for the King LT and 37.9 seconds (SD of 5.9 seconds) for the Combitube.
[39]
A comparison of the King-LT to endotracheal intubation ... - PubMed
Results: EMT-P mean placement times were 91.3 seconds (76.6-106.0) for ETT, 53.7 seconds (48.3-59.1) for ETC, and 27.0 seconds (24.3-29.7) for LT. EMT-B mean ...
[40]
Airway management by paramedics using endotracheal intubation ...
The Combitube™ and Easytube™ placements had higher success rates and required less time than tracheal intubation when paramedics were tested on manikins.
[41]
Risk of pulmonary aspiration with laryngeal mask airway and ...
Nov 6, 2009 · Complications following the use of the Combitube, tracheal tube and laryngeal mask airway. ... A study of 85 594 anaesthetics with special focus ...
[42]
The esophageal tracheal combitube as a non-invasive alternative to ...
... combitube as a non-invasive alternative to endotracheal ... The combitube allows application of high ventilatory pressures and it minimises the risk of aspiration ...
[43]
Comparison of endotracheal intubation, combitube, and laryngeal ...
LMA and Combitube had higher success rates (98.3% and 100%) and were faster than ETI (73%) in a study, regardless of experience. LMA and Combitube are ...Missing: speed | Show results with:speed
[44]
Endotracheal intubation and esophageal tracheal Combitube ...
This study attempted to analyze basic (nonparamedic) ambulance attendant success rates at ETI and ETC insertion as well as their continuing skill competency ...Missing: training | Show results with:training
[45]
https://pubmed.ncbi.nlm.nih.gov/14691782/
[46]
The PTL, Combitube, laryngeal mask, and oral airway - PubMed
The PTL, LM, and Combi appear to offer substantial advances over the OA/BVM system. Although the most costly, the Combitube was associated with the least ...Missing: tube | Show results with:tube
[47]
Supraglottic Airway Review - emDocs
Apr 3, 2014 · The Combitube, is a disposable double-lumen double cuffed device commonly inserted into the patient's esophagus but 5% of the time inserted into ...
[48]
Supraglottic airways in difficult airway management: successes ...
Nov 10, 2011 · Therefore, success rates as low as 50% have been noted for emergency medical technicians, who do not perform tracheal intubation frequently, ...
[49]
A comparison of two airway aids for emergency use by unskilled ...
Apr 6, 2002 · The Combitube (Kendall-Sheridan) has been suggested as an alternative to the laryngeal mask which, because of its design, may provide more ...
[50]
LMA or Combitube®: Which Is Best in Unskilled Hands?
Apr 1, 1999 · The authors of this industry-supported study also point out that the Combitube may provide greater protection against aspiration than the LMA.
[51]
The use of the laryngeal mask airway and Combitube® in ...
The Combitube may offer comparable airway protection to the endotracheal tube but requires more expertise for insertion than the LMA and significant airway ...
[52]
Emergency intubation with the Combitube - PubMed
The Combitube as used by ICU nurses was as effective as establishment of the endotracheal airway by intensivists during CPR. The Combitube may be used ...
[53]
Successful prehospital airway management by EMT-Ds using the ...
Objective. To evaluate the ability to train emergency medical technicians-defibrillation (EMT-Ds) to effectively use the Combitube for intubations in the ...
[54]
Use of the esophageal tracheal combitube™ by basic emergency ...
Eight hundred and thirty-one adult cardiac arrest patients were studied. Placement was successful in 725 (95.4%) of the 760 patients where it was attempted and ...
[55]
Current status of the Combitube™: a review of the literature
With blind insertion, the Combitube is successfully placed in the esophagus in more than 95% of cases (Figure 3). 3 Ventilation is achieved via the longer blue ...
[56]
Endotracheal Intubation Versus Supraglottic Airway for Airway ...
The goal of this meta-analysis is to evaluate and compare the effectiveness of endotracheal intubation (ETI) and supraglottic airway (SGA) devices in airway ...
[57]
Part 3: Adult Basic and Advanced Life Support: 2020 American ...
Oct 21, 2020 · 2020 American Heart Association Chains of Survival for IHCA and OHCA. CPR indicates cardiopulmonary resuscitation; IHCA, in-hospital cardiac ...
[58]
https://www.sciencedirect.com/science/article/abs/pii/S0952818002003562
[59]
Full article: Prehospital Supraglottic Airways: An NAEMSP Position ...
Jan 10, 2022 · Supraglottic airway (SGA) devices provide effective conduits for oxygenation and ventilation and may offer protection from gastric aspiration.
[60]
(Discontinued) Combitube, Shiley Esophageal Tracheal Airway ...
Free delivery over $200 7-day returnsEsophageal/tracheal double lumen airway for emergency or difficult intubation. Blind placement without laryngoscopes. Unique design provides patient airway.
[61]
Advanced Airway Practice Patterns and Out-of-Hospital Cardiac ...
Sep 17, 2025 · ROSC occurred in 30.8% of patients; 10.4% survived to hospital discharge, and 8.3% survived with good neurologic recovery. ROSC, survival to ...