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Ge Li

Ge Li (Chinese: 李革; born January 1967) is a Chinese-American biochemist, entrepreneur, and philanthropist best known as the founder, chairman, and CEO of WuXi AppTec, a global leader in contract research, development, and manufacturing services for the pharmaceutical and biotechnology industries.^[1]^[2] Born in China, Li earned a bachelor's degree in chemistry from Peking University in 1989 and a Ph.D. in organic chemistry from Columbia University in 1994.^[1] After serving as a founding scientist at Pharmacopeia Inc. from 1993 to 2000, he established WuXi PharmaTech (later rebranded as WuXi AppTec) in Shanghai in 2000, pioneering an integrated, open-access R&D platform that has revolutionized outsourced drug discovery and development.^[1]^[2] Under his leadership, the company grew rapidly, listing on the New York Stock Exchange in 2007 (before delisting in 2015) and achieving dual listings on the Shanghai and Hong Kong stock exchanges in 2018; by 2024, WuXi AppTec employed over 38,000 people worldwide and reported annual revenues exceeding $5.5 billion.^[1]^[2] Li, a U.S. citizen with permanent residency in China, has been recognized for his contributions to the biopharma sector, including the development of the CRDMO (contract research, development, and manufacturing organization) model that supports innovators in advancing medicines from discovery to commercialization.^[2] Through the Ge Li & Ning Zhao Family Foundation, he has made substantial philanthropic commitments to medical research and education, including a $21.5 million gift to Columbia University's Department of Chemistry in 2020 to advance research and teaching, a $20 million donation to Memorial Sloan Kettering Cancer Center in 2021 for lung cancer initiatives, and a $10 million contribution to Dana-Farber Cancer Institute in 2024 to establish the Ning Zhao and Ge Li Family Initiative in Nursing.^[3]^[4]^[5]

Early life and education

Early life

Ge Li was born in January 1967 in China.^[1] He attended the Affiliated High School of Peking University, where he completed his secondary education in the 1980s.^[6] Following his high school graduation, he entered Peking University for higher education.

Higher education

Ge Li earned a bachelor's degree in chemistry from Peking University in Beijing in 1989.^[1]^[2] He then pursued advanced studies in the United States, completing a Ph.D. in organic chemistry at Columbia University in 1994.^[2]^[7] Li's doctoral research centered on organic synthesis techniques, with a particular emphasis on creating synthetic receptors for peptides that could enable sequence-selective binding, laying groundwork for applications in pharmaceutical drug discovery.^[8]^[9] A key contribution from this period was his involvement in developing peptidosteroidal receptors targeted at opioid peptides, employing combinatorial library methods to achieve selective interactions, as co-authored in a 1994 Journal of the American Chemical Society paper under the supervision of W. Clark Still.^[8] This training under Still, a leader in computational organic chemistry and molecular design, honed Li's skills in innovative synthesis strategies essential for advancing therapeutic compound development.^[8]

Professional career

Early professional experience

Ge Li joined Pharmacopeia, Inc. as a founding scientist in 1993 in Princeton, New Jersey, earning his Ph.D. in organic chemistry from Columbia University in 1994, where he applied his expertise to early-stage drug discovery in a burgeoning biotech environment.^[10] At the company, which specialized in innovative platforms for pharmaceutical research, Li immersed himself in the competitive U.S. biotech landscape, gaining hands-on experience in scaling technologies from academic concepts to commercial applications.^[11] Li's primary contributions at Pharmacopeia centered on advancing combinatorial chemistry and drug discovery methodologies, notably through work on the ECLiPS (Encoded Combinatorial Libraries on a PS) technology.^[11] This platform facilitated the efficient encoding and synthesis of vast libraries of small-molecule compounds, enabling high-throughput screening to identify potential drug candidates more rapidly than traditional methods.^[11] His efforts supported key industry partnerships, including a 1994 collaboration with Schering-Plough to develop compounds for cancer and asthma treatments, demonstrating the practical impact of these innovations on pharmaceutical pipelines.^[11] In 1999, while still at Pharmacopeia, Li traveled to China with senior colleague John J. Baldwin to assess opportunities for outsourcing combinatorial chemistry services, including meetings with potential partners such as the Jiangsu Taihushui Group.^[11] This exposure to China's emerging scientific infrastructure and talent pool, contrasted with the high costs and regulatory hurdles of U.S.-based operations, profoundly influenced Li's perspective on global R&D dynamics.^[11] His time at Pharmacopeia thus equipped him with critical insights into biotech entrepreneurship, emphasizing the value of integrated, technology-driven approaches to drug development.^[12]

Founding and development of WuXi AppTec

In 2000, Ge Li co-founded WuXi AppTec in Shanghai, China, alongside his wife Ning Zhao, establishing it as a contract research organization (CRO) with an initial laboratory spanning 7,000 square feet.^[13]^[14] The company was launched to provide open-access research and development (R&D) services to global biopharmaceutical clients, drawing on Li's prior experience as a founding scientist at Pharmacopeia, where he helped develop a blueprint for integrated outsourcing platforms.^[2] From the outset, WuXi AppTec targeted international pharmaceutical firms by offering cost-effective chemistry services, securing early clients like Merck & Co. in 2002.^[15] The early years presented significant challenges in China, including the need to construct specialized infrastructure and attract qualified talent in a nascent biotech sector.^[15] WuXi AppTec addressed these by securing initial investments from local entities, such as the Jiangsu Taihushui Group, and obtaining loans from state banks to build facilities, including a $7.2 million site in Jinshan by 2003.^[15] For talent acquisition, the company hired rapidly from China's expanding pool of STEM graduates—reaching 300,000 annually by the early 2000s—employing 48 staff, including 27 PhDs, in its first year and investing in English training and advanced lab systems to meet global standards.^[15] These efforts enabled the firm to grow to 252 employees by 2003 while fostering trust with overseas partners through transparent online monitoring tools.^[15] Key milestones marked WuXi AppTec's evolution from a chemistry-focused CRO to a full contract research, development, and manufacturing organization (CRDMO) model during the 2000s.^[13] The company launched synthetic chemistry services in 2001, followed by process development in 2003 and R&D-scale manufacturing in 2004, allowing it to offer end-to-end support for drug discovery and production.^[13] Further expansions included bioanalytical services in 2005 and toxicology/formulation capabilities in 2007, alongside new campuses to scale operations.^[13] A pivotal 2008 acquisition of U.S.-based AppTec Laboratories for $163 million integrated biologics expertise and established a global footprint, solidifying the CRDMO platform.^[15]^[16]

Leadership roles and achievements

Ge Li has served as Chairman and Chief Executive Officer of WuXi AppTec since founding the company in 2000, guiding its transformation into a global leader in pharmaceutical research, development, and manufacturing services.^[2] Under his stewardship, the executive structure evolved in recent years to include Co-CEOs Minzhang Chen and Steve Yang, enhancing operational depth while Li maintains overall strategic direction as Chairman and CEO.^[2] This leadership has driven key milestones, including the company's initial public offering on the New York Stock Exchange in 2007, its delisting in 2015 to prioritize Asian markets, listings on the Shanghai Stock Exchange in May 2018 and the Hong Kong Stock Exchange in December 2018, and the opening of a process research and development facility in San Diego in 2016 to bolster U.S. operations.^[17]^[18]^[19] Li pioneered the development of integrated, open-access R&D platforms at WuXi AppTec, enabling seamless collaboration across drug discovery, preclinical testing, and manufacturing for biotech and pharmaceutical clients worldwide.^[2] These innovations have positioned the company as a comprehensive contract research, development, and manufacturing organization (CRDMO), supporting accelerated drug development timelines and contributing to recent financial successes, such as a 18.6% year-over-year revenue increase to RMB 32.86 billion for continuing operations in the first nine months of 2025.^[20] Li's achievements have earned him significant recognition in the industry. In 2021, Forbes China ranked him fourth among the best CEOs in China for his visionary leadership in biopharma services.^[21] As of November 2025, Forbes estimates his net worth at $7.2 billion, primarily derived from his approximately 9% stake in WuXi AppTec held through entities G&C VI Limited and G&C V Limited, as reported in the company's semi-annual filings.^[22]^[1]

Philanthropy

Educational donations

In 2018, Ge Li and his wife, Ning Zhao, donated 100 million RMB (approximately $15 million USD at the time) to Peking University, their alma mater, to establish the Li Ge-Zhao Ning Education Fund.^[23] This fund supports the recognition of outstanding students through awards and aids the university's broader educational initiatives, particularly in fostering talent in science and research fields.^[6] The donation reflects their commitment to repaying the institution that shaped their early academic foundations, with Li expressing gratitude toward his teachers and a deep affection for the university.^[24] In 2024-2025, Ge Li and the Ge Li & Ning Zhao Family Foundation each donated more than $1 million to The Peddie School, a preparatory school in New Jersey, to support its educational programs.^[25] Building on their philanthropic efforts, Li and Zhao made a significant $21.5 million gift to Columbia University's Department of Chemistry in 2020, where both earned their PhDs in organic chemistry.^[7] The contribution establishes two endowed professorships equipped with startup funds for new laboratories, one endowed fellowship for graduate students, and one endowed scholarship for undergraduates pursuing chemistry studies.^[7] These initiatives aim to enhance research capabilities and teaching excellence in chemical sciences, underscoring the couple's desire to give back to the programs that advanced their professional trajectories.^[26]

Health research contributions

Ge Li has made significant philanthropic contributions to health research, particularly in oncology, through the Ge Li & Ning Zhao Family Foundation, which he co-founded with his late wife in 2020.^[4] In 2021, the foundation donated $20 million to Memorial Sloan Kettering Cancer Center (MSK) to establish the Ning Zhao & Ge Li Family Initiative for Lung Cancer Research and New Therapies, aimed at advancing understanding of lung cancer biology and developing innovative treatments.^[4]^[27] This initiative supports multidisciplinary research efforts, including early detection, precision medicine, and therapeutic development, leveraging MSK's expertise in translational oncology.^[4] These donations align with WuXi AppTec's expertise as a global provider of integrated biopharma research, development, and manufacturing services, enabling more efficient drug discovery processes.^[2] Following the death of Ning Zhao in May 2023 after a 20-year battle with cancer, Ge Li expanded the foundation's health philanthropy to further support oncology advancements.^[14] In June 2024, the foundation gave $10 million to Dana-Farber Cancer Institute, the largest single gift for its nursing program, creating the Ning Zhao & Ge Li Family Initiative in Nursing to enhance oncology nursing education, career development, and patient care integration with research.^[5] Building on this momentum, in 2025, the foundation endowed the Ning Zhao Chair of Nursing at Lenox Hill Hospital within Northwell Health, honoring Zhao's legacy and bolstering clinical research and training in cancer care.^[28] These efforts reflect a commitment to bridging research and practical healthcare delivery, particularly in areas like lung cancer where accessibility to advanced therapies remains a global challenge.^[5]

Controversies and political involvement

Ties to Chinese government

Ge Li has maintained long-term involvement with the Chinese Communist Party (CCP) through his leadership at WuXi AppTec, where he has actively promoted Party activities and membership among employees since the company's early years. By 2013, over 1,000 of the company's approximately 7,000 employees were CCP members, with Li emphasizing their role as the "technical backbone" of the organization. Li has personally attended and supported CCP events within WuXi AppTec, commending the work of Party branches and urging members to demonstrate their affiliation visibly. In a 2013 statement, he remarked, “Party members ‘Show your affiliation’ + Party branches ‘display your badges’ = the image of the party organization,” highlighting his encouragement for active participation in company governance and operations. This involvement aligns with broader CCP strategies to embed Party structures in private enterprises, fostering alignment with national priorities in the biopharma sector. WuXi AppTec has engaged in collaborations with Chinese state-backed research institutions and military entities, as documented in 2024 reports. The company was selected by the Ministry of Science and Technology to operate the State Key Laboratory of Drug Lead Compound Research, receiving support from both economic development programs and the People's Liberation Army (PLA). Its employees co-invented treatments for altitude sickness with PLA scientists from the PLA General Hospital between 2018 and 2023, resulting in at least 10 patents filed in the U.S., Europe, and China. Additionally, WuXi AppTec has sponsored military-civil fusion events praising CCP policies and received investments from PLA-linked funds, such as the Aviation Industry Corporation of China Military-Civil Fusion Fund. These partnerships extend to joint research with the PLA Academy of Military Medical Sciences, including lectures and awards for PLA researchers. The growth of WuXi AppTec in the 2000s was supported by Chinese government policies aimed at bolstering the biotechnology sector. Founded in 2000, the company benefited from local government incentives in Wuxi, including tax breaks and preferential land use rights, which facilitated its rapid expansion. By 2007, these supports enabled its listing on the New York Stock Exchange, amid national initiatives to promote innovation in pharmaceuticals and contract research services. Such policies reflected broader efforts under the 10th and 11th Five-Year Plans to integrate private firms into state-driven development in high-tech industries.

US-China relations and BIOSECURE Act

Ge Li and WuXi AppTec have faced heightened scrutiny amid escalating U.S.-China geopolitical tensions, particularly concerning national security risks in the biotechnology sector. The BIOSECURE Act, initially introduced in the U.S. House of Representatives in January 2024, aimed to restrict federal funding and collaborations with certain Chinese biotechnology companies deemed "biotechnology companies of concern." Early versions of the bill explicitly named WuXi AppTec due to alleged ties to the Chinese government that could threaten U.S. supply chain security. If enacted in that form, the legislation would have prohibited U.S. pharmaceutical and biotechnology firms from engaging in contracts with WuXi AppTec for services such as drug development and manufacturing, potentially disrupting the company's extensive U.S. operations, including its San Diego facility focused on process R&D and GMP manufacturing. WuXi AppTec reported a 17% revenue decline in its Advanced Therapies unit through the third quarter of 2024, attributing part of the impact to early effects of the bill's passage in the House and ongoing Senate deliberations. However, as of November 2025, the bill has been revised in a version known as "BIOSECURE 2.0," passed by the Senate on November 3, 2025, as an amendment to the National Defense Authorization Act (NDAA). This updated version does not explicitly name WuXi AppTec or WuXi Biologics; instead, it relies on the Department of Defense's Section 1260H list of Chinese military companies, which does not include them. The House and Senate versions are undergoing reconciliation, with final enactment expected before the end of 2025, though the revisions have reduced the direct threat to WuXi. In line with this, WuXi AppTec reported strong financial performance in 2025, with total revenue from continuing operations up 22.5% year-over-year to RMB 32.45 billion in the first nine months, and U.S. revenues increasing 31.9% to approximately $3.1 billion, indicating recovery from earlier concerns. In response to these allegations, Ge Li, as chairman and CEO of WuXi AppTec, co-signed an open letter on February 3, 2024, alongside other company executives, asserting that the firm has operated for over 20 years without posing a national security risk to any country and emphasizing its adherence to international data privacy and security standards. The letter directly addressed claims of military and intelligence ties, denying any involvement in such activities and highlighting WuXi's contributions to global biopharma innovation. Reports from think tanks have amplified these concerns, with the Jamestown Foundation's February 2024 analysis, "Red Genes: Assessing WuXi AppTec's Ties to the Party-Army-State," detailing potential vulnerabilities in U.S. biopharma supply chains stemming from WuXi's alleged connections to the Chinese Communist Party and People's Liberation Army, urging greater caution in partnerships. A related May 2024 report by security analyst James C. Mulvenon further examined WuXi Group's government and military links, reinforcing risks to U.S. national security through integrated supply chain dependencies. Ge Li has consistently responded to these developments by reiterating WuXi AppTec's commitment to compliance with global regulations and ethical standards, stating in a March 2024 Hong Kong stock exchange filing that the company poses no security threat to the U.S. or any other nation. He has emphasized the firm's independent operations and focus on serving international clients while navigating these tensions.

Personal life

Family

Ge Li married Ning Zhao in the 1990s during their time as doctoral students in organic chemistry at Columbia University, where Li earned his PhD in 1994 and Zhao in 1995.^[29] Zhao held a bachelor's degree in chemistry from Peking University.^[30] The couple co-founded WuXi AppTec in Shanghai in 2000, with Zhao serving as executive director of the board and corporate senior vice president until her death on May 16, 2023, at age 56, following a 20-year battle with cancer.^[14]^[31] The couple's decision to return to China and establish WuXi AppTec reflected a shared commitment, as Zhao left her role at Bristol-Myers Squibb to join Li in building the venture.^[32] They had children, including a son, Michael Li, evidenced by the creation of a children's irrevocable trust in 2006 for which Zhao served as trustee, though specifics about their family life remain private and there are no public records of the children's involvement in business or philanthropy.^[33]^[34] The Ge Li & Ning Zhao Family Foundation, established by the couple, underscores their emphasis on family-oriented giving in education and health research.^[5]

Citizenship and residences

Ge Li holds United States citizenship, acquired through his advanced education at Columbia University and subsequent professional career in the American pharmaceutical sector. He also possesses a permanent residence permit for the People's Republic of China, enabling long-term residency despite China's non-recognition of dual nationality.^[22]^[1]^[35] Li's primary residence is in Shanghai, China, aligning with the headquarters of WuXi AppTec and his central role in the company's operations. His business commitments sustain a notable presence in the United States, where WuXi maintains key facilities, including expanded sites in New Jersey for drug development testing and operations in California among other locations.^[22]^[36] In his lifestyle, Li engages actively in global scientific discourse, participating in panel discussions at international conferences such as the Future Forum's Workshop on Future Medicine in 2017, where he discussed advancements in treatments for chronic diseases.^[37] He further supports international initiatives through oversight of the Ge Li & Ning Zhao Family Foundation, a U.S.-based entity that funds cross-border efforts in scientific research and education.^[38] Post-2023, Li divested from certain U.S. properties, including the sale of a 9,499-square-foot waterfront mansion in Fort Lauderdale, Florida, in May 2025 for $12.15 million—a property he had acquired in 2021 for approximately $9.13 million—while retaining his base in Shanghai amid ongoing global business travel.^[39]^[40]^[41]

References

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Bloomberg Billionaires Index - Li Ge
Li was born in January 1967. He graduated from Peking University with a bachelor's degree in chemistry in July 1989. Li obtained a Ph.D. degree in organic ...
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Our Leadership - WuXi AppTec
Ge Li, Ph.D. Chairman and CEO. Scientist and entrepreneur leading WuXi AppTec since its founding in 2000. Dr. Li pioneered an integrated, open-access R&D ...Missing: biography - | Show results with:biography -
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Columbia Chemistry Receives $21.5 Million Gift from Dr. Ge Li and ...
Jul 28, 2020 · Columbia University announced a $21.5 million gift from Dr. Ge Li '94GSAS and Dr. Ning Zhao '95GSAS to advance research and teaching in chemistry.
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Memorial Sloan Kettering Announces New Initiative to Focus on ...
May 13, 2021 · MSK today announced a $20 million gift from the Ge Li & Ning Zhao Family Foundation to support lung cancer research and the development of ...
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Jun 7, 2024 · The Ge Li & Ning Zhao Family Foundation has made an extraordinary gift of $10 million to Dana-Farber Cancer Institute, the largest single gift in support of ...
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Ge Li - Grizzly Bulls Billionaire Index
In 1989, he graduated with a B.A. from Peking University. Li pursued his Ph. D. in organic chemistry at Columbia University.
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Memorial Sloan Kettering Cancer Center has announced a $20 million gift from the Shanghai-based Ge Li and Ning Zhao Family Foundation in support of lung cancer ...
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US Senate bill targeting China's BGI, WuXi AppTec moves forward
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Pharma billionaire sells Fort Lauderdale mansion for $12 million
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Resi Roundup: Billionaire Li Ge Sells Fort Lauderdale Mansion
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Biotech executive buys Fort Lauderdale mansion (Photos)
Jul 15, 2021 · It was founded in 2000 by Zhao and her husband, Ge Li, the company's chairman and co-CEO. In 2020, Li and Zhao made a $21.5 million donation ...<|control11|><|separator|>