Fact-checked by Grok 2 weeks ago

Macula

The macula, also known as the macula lutea, is a yellowish oval-shaped region approximately 5.5 mm in diameter located at the center of the retina in the human eye, responsible for providing sharp, detailed central vision through a high concentration of cone photoreceptor cells.^[1]^[2] Positioned about 3 to 5 mm temporal to the optic disc and slightly inferior to the posterior pole, it derives its yellow hue from xanthophyll pigments such as lutein and zeaxanthin, which act as filters to protect against harmful blue and ultraviolet light while enhancing visual acuity.^[3]^[1] Structurally, the macula encompasses several key subregions: the central fovea centralis, a 1.5 mm pit with the highest density of cones (up to 200,000 per square millimeter) and no rods, enabling peak color and resolution perception; the surrounding foveola (about 350 μm in diameter), which is avascular and optimized for minimal light scattering; the parafovea (roughly 2.3 mm wide), featuring a thicker retinal layer with both cones and sparse rods; and the outer perifovea, where rod density increases, with rods beginning to outnumber cones.^[2]^[3] The foveal pit's unique architecture, including elongated cone outer segments and the oblique Henle fiber layer, minimizes chromatic aberration and maximizes spatial resolution for tasks like reading or recognizing faces.^[2] Functionally, the macula handles the bulk of fine visual discrimination, focusing light rays directly onto its cone-rich center during fixation, while its avascular foveal zone (0.2–1 mm diameter) relies on underlying choroidal circulation for oxygenation to avoid vascular interference with light transmission.^[1]^[2] The inner retina receives blood from the retinal arcades, but the outer layers, including photoreceptors and the retinal pigment epithelium (RPE), depend on the choriocapillaris for nutrients, underscoring the macula's vulnerability to conditions like age-related macular degeneration that disrupt this supply.^[2] Overall, the macula's specialized design accounts for about 2–5% of the retina's area but mediates the majority of high-acuity vision essential for daily activities.^[3]^[4]

Anatomy

Location and Dimensions

The macula lutea is located in the posterior pole of the retina, forming an oval area approximately 3 to 5 mm temporal to the optic disc and slightly inferior to its horizontal midline.^[5]^[6] This positioning centers the macula on the visual axis, aligning it with the line of direct gaze.^[7] The macula measures approximately 5.5 mm in diameter, encompassing a yellowish pigmented region due to its high concentration of xanthophyll pigments.^[2] Its thickness varies regionally, measuring about 0.15 to 0.20 mm at the central fovea and increasing to 0.23 to 0.32 mm at the perifoveal rim.^[4] The fovea centralis represents the most central portion of the macula, serving as the site of highest visual acuity and featuring the foveal pit as a prominent anatomical landmark.^[8] Embryologically, the macula arises from the central temporal region of the optic vesicle, an evagination of the diencephalon that forms the optic cup and neural retina during the fourth week of gestation.^[9]

Subregions

The macula is anatomically divided into distinct subregions based on their radial distance from the foveal center, including the fovea, parafovea, perifovea, and occasionally the juxtamacular area adjacent to the perifovea. The fovea represents the centralmost zone with a diameter of approximately 1.5 mm, encompassing the highest density of specialized structures for sharp vision. The parafovea forms an annular ring surrounding the fovea, extending from an inner diameter of 1.5 mm to an outer diameter of 2.5 mm from the foveal center. The perifovea constitutes a broader annular ring beyond the parafovea, with an inner diameter of 2.5 mm and an outer diameter of 5.5 mm, marking the peripheral boundary of the macula. These boundaries delineate zones of progressively changing retinal architecture within the overall macular area of about 5.5 mm in diameter.^[2] Within the fovea, the foveola is the innermost portion, measuring roughly 0.35 mm in diameter and serving as the site of peak visual resolution.^[10] The foveal avascular zone, a capillary-free region devoid of retinal blood vessels, lies centrally within the fovea and spans approximately 0.5 mm in diameter, ensuring unobstructed light transmission to the underlying photoreceptors. This avascularity distinguishes the fovea from surrounding vascularized areas and contributes to its role in high-acuity central vision. Morphologically, the fovea displays notable thinning compared to adjacent regions, attributable to the dense packing of cones that displaces other retinal elements laterally. In contrast, the parafovea and perifovea exhibit gradually increasing retinal thickness and a progressive rise in rod presence moving outward from the foveal center, reflecting a transition toward broader visual functions.^[11] The term "macula lutea," historically applied to the entire region, derives from its yellowish appearance observed in early anatomical studies.^[7]

Histological Layers

The macula exhibits a stratified histological architecture that closely mirrors the general retinal structure but features specialized adaptations for enhanced visual acuity. From the innermost to outermost layers, these include the internal limiting membrane, formed by the footplates of Müller glial cells; the nerve fiber layer, which is notably thinner in the macula due to the lateral displacement of ganglion cell axons away from the foveal center; the ganglion cell layer, containing the cell bodies of retinal ganglion cells; the inner plexiform layer, where synapses occur between bipolar and ganglion cells; the inner nuclear layer, housing bipolar, horizontal, and amacrine cell bodies; the outer plexiform layer, site of photoreceptor-bipolar-horizontal cell synapses; the outer nuclear layer, dominated by cone cell bodies in the fovea with minimal rod presence; the external limiting membrane, a fenestrated layer of adherens junctions between photoreceptors and Müller cells; the photoreceptor layers, comprising inner segments (metabolic machinery) and outer segments (light-sensitive discs); and the retinal pigment epithelium, a single layer of cuboidal cells essential for phagocytosis and nutrient transport.^[7]^[12]^[13] In the fovea, a key macular subregion, macula-specific adaptations optimize light access to photoreceptors: inner retinal layers (nerve fiber, ganglion cell, inner plexiform, and inner nuclear) are displaced centrifugally, creating a foveal pit that thins these layers over the central 350 μm diameter foveola. This displacement, combined with elongated cone outer segments and tightly packed photoreceptors, results in a cone density peaking at approximately 200,000 cones/mm² in the foveola, with virtually no rods present to maximize color discrimination and resolution.^[12]^[2]^[14] The macula's blood supply derives primarily from the choroidal circulation via the choriocapillaris, which nourishes the outer retina including photoreceptors and retinal pigment epithelium, while branches of the central retinal artery supply the inner layers through superficial, intermediate, and deep capillary plexuses. A distinctive feature is the foveal avascular zone, a capillary-free region approximately 500–600 μm in diameter centered on the foveola, ensuring unobstructed light transmission to the high-density cones.^[7]^[15] The macula's characteristic yellow pigmentation arises from the carotenoids lutein and zeaxanthin, concentrated predominantly in the Henle fiber layer (oblique cone axon bundles) and to a lesser extent in photoreceptor outer segments and Müller cell processes, where they absorb short-wavelength blue light to reduce chromatic aberration and enhance contrast sensitivity.^[16]^[12]^[2]

Physiology

Central Vision Processing

The macula is responsible for the central 10–20 degrees of the visual field, providing high spatial resolution essential for tasks such as reading, face recognition, and fine motor activities.^[17]^[18] This region enables precise perception of details by concentrating neural resources on a small area of the visual scene, allowing for the discrimination of fine patterns that are critical for everyday visual demands.^[18] Visual acuity in the macula arises from the dense packing of cones in the fovea, which supports spatial sampling at resolutions of 1–2 arcminutes.^[19] This high density, reaching up to approximately 200,000 cones per square millimeter in the foveola, minimizes the spacing between photoreceptors and enables sharp image formation.^[20] Additionally, neural convergence ratios differ markedly across the retina: in the central fovea, midget bipolar and ganglion cells often exhibit a near 1:1 connection with individual cones, preserving fine detail, whereas peripheral regions show higher convergence (up to 100:1 or more), which reduces resolution but enhances sensitivity.^[21]^[22] During fixation, the macula maintains stable gaze on targets of interest, while saccades—rapid eye movements—shift the fovea to new points to build a coherent view of the scene.^[23] Microsaccades, small involuntary movements occurring during attempted fixation, play a key role in stabilizing the foveal image by counteracting neural adaptation and preventing perceptual fading, thus sustaining clarity on the macula.^[24]^[23] In contrast to the peripheral retina, which excels at detecting motion and low-contrast changes over wide areas through rod-dominated processing, the macula specializes in resolving form, texture, and high-contrast details within its limited field.^[18]^[25] This functional division allows the visual system to allocate resources efficiently, with the macula handling precise, stationary analysis and the periphery monitoring dynamic environmental cues.^[18]

Photoreceptor Specialization

The macula exhibits a distinctive predominance of cone photoreceptors compared to the rod-dominated peripheral retina, with the central foveola containing nearly 100% cones and excluding rods entirely. This cone-packed arrangement, peaking at approximately 199,000 cones per mm², enables high spatial acuity and photopic (daylight) vision essential for detailed central vision tasks. In contrast, rods, which outnumber cones in the parafoveal and perifoveal regions of the macula, support scotopic (low-light) sensitivity but are absent from the rod-free foveola, which spans an average diameter of 0.35 mm (about 1.25 degrees of visual angle).^[14]^[26]^[27] The cones in the macula are specialized into three subtypes based on their peak spectral sensitivities: long-wavelength-sensitive (L-cones, sensitive to red light around 564 nm), medium-wavelength-sensitive (M-cones, sensitive to green light around 534 nm), and short-wavelength-sensitive (S-cones, sensitive to blue light around 420 nm). These subtypes form the basis of trichromatic color vision, with approximate ratios in the fovea of 2:1:0.05 for L:M:S cones, though S-cone density is particularly low at about 1.5% in the central foveola and increases peripherally. This distribution supports color discrimination and fine detail perception under well-lit conditions, with L- and M-cones dominating to optimize luminance and chromatic signals.^[28]^[29] The absence of rods in the central foveola results in an absolute scotoma under scotopic conditions, where rod-mediated vision is required, rendering the fixation point invisible as no photoreceptors respond to low light levels there. This rod-free zone ensures unobstructed light access to cones for maximal acuity but limits central vision in dim environments.^[30] Macular pigments, primarily lutein and zeaxanthin concentrated in the fovea, play a protective role by preferentially absorbing harmful short-wavelength blue light (around 400-500 nm), thereby reducing photo-oxidative stress and reactive oxygen species damage to photoreceptors. These xanthophyll carotenoids act as optical filters and antioxidants, mitigating light-induced injury in the vulnerable macular region.^[31]^[32]

Pathology

Age-related macular degeneration (AMD) is a progressive eye disease that affects the macula, the central part of the retina responsible for sharp, detailed vision, and is the leading cause of irreversible vision loss and blindness in individuals over 50 years old in developed countries.^[33] Globally, AMD affects approximately 200 million people as of 2020, with projections estimating an increase to nearly 300 million by 2040 due to aging populations.^[34] In the United States, an estimated 19.8 million adults aged 40 and older (about 12.6% of this demographic) were living with AMD in 2019.^[35] AMD manifests in two primary forms: dry (non-exudative or atrophic) AMD, which accounts for 85-90% of cases and involves gradual degeneration, and wet (neovascular or exudative) AMD, which comprises 10-15% of cases but is responsible for the majority of severe vision loss due to rapid progression.^[36] The pathophysiology of dry AMD centers on the accumulation of drusen, extracellular deposits between the retinal pigment epithelium (RPE) and Bruch's membrane, which disrupt nutrient exchange and lead to RPE atrophy and photoreceptor loss over time.^[33] In wet AMD, breakdown of Bruch's membrane triggers choroidal neovascularization, where abnormal blood vessels grow from the choroid into the subretinal space, causing leakage of fluid and blood that damages the RPE, photoreceptors, and macula.^[37] These processes result in the thinning and scarring of the macula, severely impairing central vision while peripheral vision remains largely unaffected.^[38] Key risk factors for AMD include advanced age, which is the strongest predictor as incidence rises exponentially after 60 years, with prevalence increasing from less than 1% in those under 60 to over 30% in those over 80.^[39] Smoking doubles the risk by promoting oxidative stress and inflammation in the retina, while genetic variants such as the Y402H polymorphism in the complement factor H (CFH) gene on chromosome 1 impair immune regulation and increase susceptibility to drusen formation.^[40] Additional contributors involve chronic oxidative stress from environmental factors like prolonged exposure to blue light and UV radiation, which generate reactive oxygen species that overwhelm retinal antioxidants and accelerate RPE dysfunction.^[41] Symptoms of AMD typically emerge in intermediate and advanced stages, with early disease often asymptomatic and detectable only through retinal imaging.^[42] Intermediate AMD may present with mild central vision distortions, known as metamorphopsia, where straight lines appear wavy, or difficulty adapting to low light.^[43] In advanced stages, both dry and wet forms lead to significant central vision loss, manifesting as blurred or blank spots in the center of the visual field, challenges with reading or recognizing faces, and a reliance on peripheral vision for daily tasks.^[44] Progression of AMD is classified by the Age-Related Eye Disease Study (AREDS) system into early, intermediate, and late stages based on drusen size, pigmentary changes, and presence of advanced features.^[42] Early AMD features small drusen (<63 μm) and minimal pigment abnormalities without vision impairment; intermediate AMD involves medium drusen (63-125 μm), hyperpigmentation or hypopigmentation of the RPE, and subtle visual changes; late AMD encompasses geographic atrophy in dry cases (extensive RPE loss >175 μm) or neovascularization in wet cases, both causing profound central scotomas.^[42] This staging helps track the disease's advancement, with about 10-20% of dry cases progressing to the wet form over time.^[45]

Other Macular Disorders

Diabetic macular edema (DME) represents a significant vascular complication in patients with diabetes, characterized by retinal thickening and swelling due to the accumulation of fluid in the macula from leaky retinal blood vessels resulting from breakdown of the blood-retina barrier.^[46]^[47] This condition often manifests as cystoid macular edema, where fluid collects in cyst-like spaces within the retinal layers, primarily affecting the inner and outer plexiform layers.^[48] The prevalence of DME among diabetic patients varies by type and duration of diabetes, ranging from 4.2% to 7.9% in type 1 diabetes and 1.4% to 5.57% in type 2 diabetes, though overall estimates indicate it impacts approximately 7-10% of individuals with diabetes over time.^[49]^[46] Macular holes are full-thickness defects in the macular retina, typically arising from vitreomacular traction where anomalous posterior vitreous detachment exerts mechanical stress on the fovea, leading to structural breaks in the neurosensory retina.^[50] The International Vitreomacular Traction Study Group classification delineates stages from 0 to 4: stage 0 involves vitreomacular adhesion without traction; stage 1 features vitreomacular traction without a hole; stages 2-4 describe full-thickness macular holes of increasing size (small <250 μm, medium 250-400 μm, large >400 μm), often with associated epiretinal membranes or schisis in later stages.^[51] These defects disrupt the continuity of the inner retinal layers, particularly the internal limiting membrane and Müller cells, contributing to central vision loss.^[52] Central serous chorioretinopathy (CSC) is an idiopathic condition involving serous detachment of the neurosensory retina due to fluid accumulation beneath the retinal pigment epithelium (RPE), often linked to hyperpermeability of the choroidal vasculature.^[53]^[54] It predominantly affects young males aged 30-50 years, with a higher incidence in men (approximately 6 times that in women) and associations with psychosocial stress, corticosteroid use, and type A personality traits.^[55]^[56] The annual incidence is estimated at 9.9 per 100,000 in men and 1.7 per 100,000 in women, with fluid leakage typically resolving spontaneously but potentially recurring and causing RPE alterations if chronic.^[55] Inherited macular disorders encompass hereditary conditions that progressively impair macular function through genetic mutations affecting retinal metabolism and structure. Stargardt disease, the most common inherited macular dystrophy, results from biallelic mutations in the ABCA4 gene, which encodes a photoreceptor-specific ATP-binding cassette transporter; this leads to impaired clearance of toxic byproducts, causing bisretinoid lipofuscin buildup in the RPE and subsequent photoreceptor degeneration.^[57]^[58] Best disease, or vitelliform macular dystrophy type 2 (VMD2), arises from autosomal dominant mutations in the BEST1 (VMD2) gene, which encodes bestrophin-1, a chloride channel in the RPE basolateral membrane; these mutations disrupt RPE function, resulting in characteristic yellow, egg-yolk-like vitelliform lesions in the subretinal space due to accumulation of lipofuscin-laden material.^[59]^[60] Both conditions primarily target the outer retinal layers, including the RPE and photoreceptors, leading to central scotomas and vision loss typically beginning in childhood or adolescence.^[57] Inflammatory conditions affecting the macula often involve uveitis, where intraocular inflammation extends to the posterior segment, causing macular involvement through cytokine-mediated vascular leakage and breakdown of the blood-retinal barrier.^[61] Uveitic macular edema, a key manifestation, occurs in 20-70% of uveitis cases depending on diagnostic methods, with higher rates (up to 51.9% overall) in intermediate, posterior, and panuveitis subtypes.^[62]^[63] This edema accumulates fluid in the retinal layers, particularly the outer plexiform layer, leading to cystoid changes and visual impairment without systemic causes being detailed here.^[64]

References

[1]
Macula lutea: MedlinePlus Medical Encyclopedia
Nov 8, 2023 · It is the part of the retina that is responsible for sharp, detailed central vision (also called visual acuity).Missing: anatomy | Show results with:anatomy
[2]
Clinical anatomy of the macula - PMC - PubMed Central - NIH
Anatomical Landmarks of the Macula. The macula lutea, a central retinal area approximately 5.5 mm in diameter, is predominantly populated by cone ...
[3]
Simple Anatomy of the Retina - Webvision - NCBI Bookshelf - NIH
May 1, 2005 · Macula lutea. The whole foveal area including foveal pit, foveal slope, parafovea and perifovea is considered the macula of the human eye.
[4]
Macula Lutea - MeSH - NCBI - NIH
An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk.
[5]
Normal Macula - Ento Key
Mar 9, 2019 · The macula (macula lutea or central retina) is defined as that portion of the posterior retina that contains xanthophyll and two or more layers of ganglion ...
[6]
Anatomy, Head and Neck: Eye Retina - StatPearls - NCBI Bookshelf
The macula, also called the macula lutea for its yellowish pigmented appearance, makes up the most sensitive area of the retina, offering the highest visual ...Missing: dimensions | Show results with:dimensions
[7]
Facts and Figures Concerning the Human Retina - Webvision - NCBI
May 1, 2005 · The retina is thinnest at the foveal floor (0.10, 0.150-0.200 mm) and thickest (0.23, 0.320 mm) at the foveal rim.Size of the Retina · Cross Diameter of the Central... · Vertical Thickness of the...
[8]
Anatomy, Head and Neck, Eye Fovea - StatPearls - NCBI Bookshelf
Aug 28, 2023 · [5] The macula is about 5.5 mm in diameter, while the fovea is 0.35 mm in diameter. Furthermore, the fovea has about 50 cone cells per 100 ...
[9]
Embryology, Eye - StatPearls - NCBI Bookshelf - NIH
At four weeks gestation, the optic vesicle invaginates and creates the optic cup [1] (Figure 1C) - this will become the retina. Grooves form along the ventral ...Development · Molecular Level · Clinical Significance
[10]
Human photoreceptor cells from different macular subregions have ...
The fovea contains all inner retinal cell types, and rod and cone photoreceptor cells reach approximately equal densities within this region (1). The parafovea ...Missing: boundaries | Show results with:boundaries
[11]
Age-Related Macular Degeneration, a Mathematically Tractable ...
The parafovea is a 1.0 mm-wide annulus (0.5–1.5 mm, inner-outer radius) surrounding the fovea, where rods intrude between cones. The perifovea is a 1.5 mm-wide ...
[12]
Simple Anatomy of the Retina by Helga Kolb - Webvision
Oct 8, 2011 · Macula lutea. The whole foveal area including foveal pit, foveal slope, parafovea and perifovea is considered the macula of the human eye.
[13]
Histology, Retina - StatPearls - NCBI Bookshelf - NIH
Photoreceptors (rods and cones) - form the outer nuclear layer. Synapse with bipolar cells at the outer plexiform layer · Bipolar cells - make up the inner ...
[14]
Human photoreceptor topography - PubMed - NIH
Feb 22, 1990 · The average human retina contains 4.6 million cones (4.08-5.29 million). Peak foveal cone density averages 199,000 cones/mm2 and is highly ...Missing: foveola | Show results with:foveola
[15]
The role of the retinal vasculature in age-related macular degeneration
Sep 6, 2023 · The blood supply to the retina arises from the ophthalmic artery ... fovea centralis in an area known as the foveal avascular zone (FAZ).
[16]
Lutein and Zeaxanthin and Their Roles in Age-Related Macular ...
Feb 16, 2022 · Lutein and zeaxanthin are the only dietary carotenoids that accumulate in the retina, specifically the macula, and are called macular pigments.
[17]
Functional and cortical adaptations to central vision loss - PMC
Since 1 deg of visual angle spans about 0.3 mm on the retina, the macula corresponds to the central 15–20 deg in the visual field. AMD often results in central ...
[18]
Neuroanatomy, Retina - StatPearls - NCBI Bookshelf - NIH
Aug 8, 2023 · The retina is the innermost layer in the eye that is responsible for the visual processing that turns light energy from photons into three-dimensional images.Missing: motion | Show results with:motion
[19]
ASTR 5110 (Majewski) Lecture Notes - The University of Virginia
Based on the above figure and logic, effective resolution at fovea is 1-2 arcmin, depending on diffraction versus pixel spacing limit. However, the eye ...
[20]
Volume 2, Chapter 2. Neuro-Ophthalmologic Examination
The fovea centralis contains approximately 200,000 cones/mm2. Outside the fovea, the average density of cones is about 5,000/mm2, but the distribution of cones ...
[21]
The Architecture of the Human Fovea - Webvision - NCBI Bookshelf
Feb 7, 2020 · We summarize the development, structure, different neural types and neural circuitry in the human fovea.
[22]
Characterization of the development of the high-acuity area of the ...
The ratio of cones to RGCs in the fovea can be one-to-three, while outside of the fovea, there is convergence of signals emanating from many photoreceptors ...
[23]
The Role of Eye Movements During Visual Fixation
In summary, microsaccades produced during visual fixation prevent neural adaptation. They do so, at least partially, by inducing visual neurons to keep firing ...
[24]
Article Microsaccades Counteract Visual Fading during Fixation
Jan 19, 2006 · Some studies have suggested that fixational microsaccades refresh retinal images, thereby preventing adaptation and fading.
[25]
Peripheral vision: Tests, issues and FAQs
While the macula is made up of cones, the peripheral retina is made up of rods. This means that the macula is sensitive to color and can focus on smaller ...
[26]
Functional Specialization of the Rod and Cone Systems - NCBI - NIH
Rods are sensitive to light with low resolution, while cones have high resolution, are less sensitive, and enable color vision. Rods are for low light, cones ...
[27]
Macular pigment and its contribution to visual performance and ...
The term macula lutea is actually attributable to the presence of the xanthophyll pigments, L, Z, and meso-Z at the central region of the retina, which give ...Missing: dimensions | Show results with:dimensions
[28]
Cones and Color Vision - Neuroscience - NCBI Bookshelf - NIH
A special property of the cone system is color vision. Perceiving color allows humans (and many other animals) to discriminate objects on the basis of the ...Missing: ratios LMS
[29]
Design of a Trichromatic Cone Array - PMC - PubMed Central - NIH
Feb 12, 2010 · The central human fovea contains only ∼1.5% S cones, with the fraction increasing to ∼7% at greater retinal eccentricities [1].
[30]
Psychophysically measuring the efficiency of rods - PMC
Feb 3, 2025 · Indeed, with the rods absent within the foveola (Curcio et al., 1990), the fixation point was not visible in scotopic vision, as vision relies ...
[31]
The Macular Carotenoids: A Biochemical Overview - PubMed Central
A mixture of lutein plus zeaxanthin (dashed black line) closely approximates the absorption spectrum of the macular pigment in the living human eye. 3. Macular ...
[32]
Why has Nature Chosen Lutein and Zeaxanthin to Protect the Retina?
Macular xanthophylls are thought to combat light-induced damage mediated by reactive oxygen species by absorbing the most damaging incoming wavelength of light ...
[33]
Age-Related Macular Degeneration - PubMed Central - NIH
Sep 26, 2022 · The greatest global root of irremediable amaurosis in the venerable is age-related macular degeneration (AMD), a complex eye condition.
[34]
Trends and disparities in disease burden of age-related macular ...
The number of patients affected by AMD is expected to increase globally, from around 200 million in 2020 to nearly 300 million in 2040 (6, 7). Vision ...
[35]
VEHSS Modeled Estimates: Age-Related Macular Degeneration ...
May 15, 2024 · In 2019, an estimated 19.8 million (12.6%) Americans aged 40 and older were living with age-related macular degeneration (AMD).
[36]
Wet Age-Related Macular Degeneration (AMD) - StatPearls - NCBI
Aug 11, 2024 · Approximately 10% of patients with age-related macular degeneration develop choroidal neovascularization, which is the hallmark of wet age- ...
[37]
Age-Related Macular Degeneration - EyeWiki
... choroidal neovascular membrane in exudative age-related macular degeneration. ... Advanced disease may involve focal areas of retinal pigment epithelium (RPE) ...
[38]
Exploring the pathogenesis of age-related macular degeneration
When the disease progresses into late AMD, vision is affected due to death of the RPE and the light-sensitive photoreceptors. The RPE is essential to the health ...Abstract · Introduction · Clinical definitions and... · The role of the retinal pigment...
[39]
Prevalence and incidence of age-related macular degeneration in ...
Our pooled prevalence estimate of early or intermediate AMD and any late AMD in those 60 years and older was 25.3% (95% CI 18.0% to 34.4%) and 2.4% (95% CI 1.8% ...
[40]
Cigarette Smoking, CFH, APOE, ELOVL4, and Risk of Neovascular ...
Conclusions Smoking and having the CFHCC genotype independently increase risk of neovascular AMD. APOE and ELOVL4 genotypes do not seem to modify risk. Clinical ...
[41]
Interlink between Inflammation and Oxidative Stress in Age-Related ...
Age is the foremost risk factor for AMD development. Aging involves physiological changes at the inflammatory and oxidative stress levels that, in combination ...
[42]
Age-related macular degeneration classification - NCBI - NIH
Significant visual loss (6/18 or worse) associated with: a). Dense or confluent drusen OR. b). Advanced pigmentary changes and/or atrophy OR. c).Missing: symptoms | Show results with:symptoms
[43]
Age-Related Macular Degeneration - Patients
Symptoms. In early stages, AMD may have no symptoms at all. When the disease progresses, the symptoms are: Distortion (warping) of straight lines; A decrease ...
[44]
Stages of age-related macular degeneration - MedicalNewsToday
Dry AMD progresses through three stages: early, middle (intermediate), and late stages. Early stage typically causes no symptoms and can only be detected ...Stages · Progression · Eyes at different stages
[45]
Age-Related Macular Degeneration: What Do We Know So Far?
In most cases AMD starts as the dry type and in 10–20% of individuals, it progresses to the wet type [12].
[46]
Diabetic Macular Edema: Current Understanding, Molecular ...
DME is considered as the retinal thickening, which involves or approaches the fovea due to abnormal accumulation of fluid in the macula under diabetic ...Missing: leaky | Show results with:leaky
[47]
Three Major Causes of Metabolic Retinal Degenerations and Three ...
The BRB breakdown causes diabetic macular edema (DME) which is one of the leading causes of vision loss in DR besides neovascularization [161,162].Missing: swelling | Show results with:swelling
[48]
Mechanisms of macular edema - PMC - PubMed Central - NIH
Mar 7, 2023 · Macular edema is the pathological accumulation of fluid in the central retina. It is a complication of many retinal diseases, including diabetic retinopathy.Missing: swelling | Show results with:swelling
[49]
Epidemiology of diabetic retinopathy, diabetic macular edema and ...
Among the population-based studies, prevalence of DME among patients with type 1 diabetes was between 4.2 and 7.9 %. In patients with type 2 diabetes, it was ...
[50]
Macular Hole - StatPearls - NCBI Bookshelf - NIH
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013 Dec;120(12): ...
[51]
The International Vitreomacular Traction Study Group classification ...
The International Vitreomacular Traction Study (IVTS) Group was convened to develop an optical coherence tomography (OCT)-based anatomic classification system.
[52]
Macular Holes: Main Clinical Presentations, Diagnosis, and Therapies
In this classification, FTMHs are associated (early stage) or not (end stage) with a vitreomacular traction (VMT) derived from a vitreomacular adhesion (VMA).
[53]
Central Serous Chorioretinopathy - StatPearls - NCBI Bookshelf - NIH
Central serous chorioretinopathy is a retinal disorder characterized by localized serous detachment of the macula. It is secondary to retinal pigment epithelial ...
[54]
Unraveling the Puzzle of Central Serous Chorioretinopathy
Jul 29, 2023 · It is believed that hyperpermeable choroidal vessels lead to increased tissue hydrostatic pressure, which results in RPE damage and subretinal ...
[55]
Gender variation in central serous chorioretinopathy - PMC
Jul 9, 2018 · The annual incidence of CSC, for example, in the Olmstead County, Minnesota population study was 9.9 for men and 1.7 for women per 100,000 ...
[56]
Blinded by Stress: A Patient and Physician Perspective on Central ...
Feb 22, 2024 · Central serous chorioretinopathy mainly affects men aged 30–50, is associated with stress, and the main symptom is blurring of central vision.Missing: idiopathic | Show results with:idiopathic
[57]
Mutations in ABCA4 result in accumulation of lipofuscin ... - PubMed
Mar 1, 2004 · Mutations in ABCA4, which encodes a photoreceptor specific ATP-binding cassette transporter (ABCR), cause autosomal recessive forms of human blindness due to ...Missing: buildup | Show results with:buildup
[58]
Stargardt Disease - StatPearls - NCBI Bookshelf
Stargardt disease is a genetic disorder that leads to the accumulation of lipofuscin, a metabolic waste product, in the retina.Missing: buildup | Show results with:buildup<|separator|>
[59]
Best Disease - StatPearls - NCBI Bookshelf - NIH
Best disease (Best vitelliform macular dystrophy, BVMD) is a rare autosomal dominant disorder due to the mutation of BEST1 (or VMD2, TU15B) gene.
[60]
153700 - MACULAR DYSTROPHY, VITELLIFORM, 2; VMD2 - OMIM
Best vitelliform macular dystrophy (VMD2) is an early-onset autosomal dominant disorder characterized by large deposits of lipofuscin-like material in the ...
[61]
Uveitic Macular Edema - StatPearls - NCBI Bookshelf
Uveitic macular edema is a complication of acute or chronic uveitis. Characterized by the accumulation of fluid in the retinal layers or the subretinal space.
[62]
Epidemiology of Macular Edema in Uveitis - PubMed
Mar 1, 2019 · Reported rates of uveitic ME ranging from 20% to 70%, depending on the ancillary tests used (fundus examination, fluorescein angiography, optical coherence ...
[63]
Prevalence, clinical characteristics, and independent predictors of ...
Apr 22, 2024 · The prevalence of UME was 51.9%. UME was found in 33.9%, 56.9%, and 54.1% of the intermediate, posterior, and panuveitis cases, respectively.
[64]
Update on the Management of Uveitic Macular Edema - PMC - NIH
Sep 14, 2021 · Uveitic macular edema (ME) is a frequent complication in 8.3% of uveitis patients and is a leading cause of serious visual impairment in about ...