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Mesotherapy

Mesotherapy, also referred to as local intradermal therapy (LIT), is a medical technique that involves the administration of small doses of medications, vitamins, minerals, enzymes, or other bioactive substances directly into the dermis—the middle layer of the skin (derived from the mesoderm)—using fine needles to achieve localized therapeutic effects.^[1] This method, which can include multiple intradermal or subcutaneous injections over or near the affected area, aims to modulate drug absorption for prolonged local action while minimizing systemic exposure and side effects.^[2] The origins of mesotherapy trace back to ancient needling practices in Chinese and Indian medicine, but its modern form was developed in 1952 by French physician Dr. Michel Pistor, who initially applied it to manage pain and vascular disorders using procaine injections.^[1] Pistor coined the term "mesotherapy" in 1958 through a publication in a local medical journal, and he founded the French Society of Mesotherapy in 1964, earning recognition as the "Father of Mesotherapy."^[2] By 1987, the French National Academy of Medicine had officially acknowledged it as an integrated medical specialty, leading to its widespread adoption across Europe, South America, Asia, and the United States, particularly for off-label applications.^[2] Mesotherapy is employed for a range of therapeutic and cosmetic purposes, including the treatment of localized musculoskeletal pain (such as low back pain, osteoarthritis, and fibromyalgia), where randomized controlled trials have demonstrated statistically significant reductions in pain and improvements in function using lower drug doses compared to traditional methods.^[1] It is also used for chronic venous insufficiency, alopecia, and skin aging through biorejuvenation, as well as cosmetic goals like cellulite reduction and localized fat dissolution via lipolytic or ablative injections.^[2] In cosmetic contexts, substances such as phosphatidylcholine are commonly injected to target subcutaneous fat, though effects are often temporary as fat cells can refill.^[3]^[4] Despite some evidence supporting its efficacy in pain management and certain dermatological applications, mesotherapy's overall scientific validation remains limited by small sample sizes, lack of standardization in drug mixtures, and insufficient large-scale randomized trials, prompting calls for further research; recent systematic reviews as of 2024 continue to highlight promising results in areas like hair loss treatment but emphasize the need for more robust trials.^[1]^[5] Safety concerns include risks of infection, allergic reactions, and tissue damage if performed without sterile conditions or by unqualified practitioners, necessitating informed consent and restriction to licensed medical professionals in jurisdictions like Italy.^[1] In the United States, while individual components may be FDA-approved for other uses, mesotherapy itself lacks FDA approval for cosmetic fat reduction or hair loss treatments, and unapproved formulations have been linked to adverse reactions such as inflammation and scarring.^[6]^[7]

Overview

Definition

Mesotherapy is a minimally invasive medical technique that involves the administration of multiple microinjections of therapeutic substances directly into the mesoderm or subcutaneous tissue to achieve localized drug delivery.^[2] The method was developed in 1952 by French physician Michel Pistor, who coined the term "mesotherapy" in 1958 and initially applied it for treating pain and vascular disorders.^[8] Etymologically, "mesotherapy" derives from the Greek words "mesos," meaning middle or intermediate, and "therapeia," referring to medical treatment, highlighting its focus on the middle layer of the skin, known as the mesoderm.^[8] This layer, the primary germ layer that develops into connective tissues, muscles, and vascular structures, is targeted to promote direct therapeutic effects at the site of injection without widespread distribution.^[9] In contrast to systemic injections such as intravenous (IV) or intramuscular (IM) methods, which circulate drugs throughout the body and often require higher doses, mesotherapy employs superficial injections—typically no deeper than 4 mm—using minimal volumes of compounds to minimize side effects and enhance site-specific efficacy.^[2] Pistor himself described it as an approach of "little volume, few times, and in the right place," emphasizing its precision and reduced systemic exposure.^[8]

Principles

Mesotherapy operates on the principle that intradermal and subcutaneous injections stimulate the mesoderm, the middle germ layer of embryonic origin that gives rise to connective tissues, to initiate reparative processes. The mechanical action of the needle induces microtrauma, triggering mechanotransduction pathways that activate local cellular responses, while the injected substances diffuse slowly into surrounding tissues to promote neovascularization, enhanced lymphatic drainage, and overall tissue repair. This biological foundation posits that such stimulation fosters a regenerative environment by modulating the dermal extracellular matrix and supporting vascular and lymphatic networks essential for nutrient delivery and waste removal.^[1]^[2] Pharmacologically, mesotherapy employs low-dose, multi-point delivery into the intradermal or subcutaneous layers to establish a localized "meso reservoir," where the administered agents form a depot for gradual release over time. This approach contrasts with traditional oral or intravenous routes by minimizing systemic circulation and first-pass metabolism in the liver, thereby achieving higher local concentrations with substantially lower total drug volumes compared to systemic administration. The sustained diffusion from this reservoir ensures prolonged therapeutic action at the target site, optimizing efficacy while curtailing widespread distribution.^[1]^[10] Central mechanisms include the enhanced local bioavailability of injected compounds, which directly access the dermal vasculature and bypass hepatic processing, leading to more efficient uptake by resident cells. These injections activate key cellular components such as fibroblasts, which proliferate and synthesize collagen to bolster tissue integrity; adipocytes, which may undergo metabolic modulation for localized remodeling; and immune cells, which contribute to inflammatory resolution. Through these interactions, mesotherapy theoretically amplifies reparative signaling, such as via glial cell modulation in the dermis, to coordinate anti-inflammatory and proliferative effects.^[1]^[10]^[2] The theoretical advantages of this methodology lie in its targeted intervention on connective tissue layers, potentially reducing side effects associated with higher systemic doses, such as gastrointestinal upset or cardiovascular strain, by limiting exposure to non-target organs. By concentrating effects in the mesodermal structures, it aims for precise modulation of pathological processes like fibrosis or localized inflammation, with a lower incidence of adverse events reported in principle due to the drug-sparing nature of the delivery.^[1]^[2]

History

Origins

The concept of injecting substances into the skin for therapeutic purposes has roots in ancient medical practices. Needle-based techniques date back to Hippocrates around 400 B.C., who used cactus spines for pain relief, and to traditional Chinese medicine, where acupuncture has been practiced for over 2,000 years to stimulate healing.^[2] Similar dermal injection methods appear in ancient Indian traditions, though mesotherapy as a distinct modern technique was developed in 1952 by Michel Pistor, a French general practitioner, initially as a technique for treating vascular disorders and chronic pain through targeted intradermal injections.^[2] Pistor, often regarded as the father of mesotherapy, drew from his clinical observations of patients with circulatory issues and persistent pain, seeking a method to deliver medications directly to affected tissues with minimal systemic effects.^[2] This approach emerged during a period when French medicine was exploring localized therapies to improve efficacy while reducing side effects compared to traditional systemic administration.^[2] The technique was first formally described in medical literature in 1958, when Pistor published an article in a local French medical journal and coined the term "mesotherapy," deriving it from "mesoderm" to reflect its focus on injecting into the middle germ layer of the skin.^[2] In this publication, Pistor outlined the basic principles of administering small doses of active substances into the dermis to achieve therapeutic effects at the site of pathology, particularly for conditions involving poor circulation and inflammation.^[2] This marked the initial documentation of mesotherapy as a distinct medical practice, building on Pistor's earlier experiments with procaine injections that unexpectedly improved hearing in an asthmatic patient, prompting further exploration of intradermal delivery.^[2] Early conceptualization of mesotherapy was influenced by a blend of homeopathic and allopathic traditions, emphasizing the use of minute, diluted doses to stimulate healing while incorporating conventional pharmaceuticals.^[2] It also drew from established practices such as intradermal vaccination techniques, which demonstrated the efficacy of superficial skin injections for immune response, and local anesthesia methods, like procaine administration, to provide targeted pain relief without widespread distribution.^[2] These influences allowed Pistor to adapt existing knowledge into a polyvalent, regionalized therapy that prioritized proximity to the lesion for optimal drug action.^[2] A pivotal early publication formalizing mesotherapy for rheumatological applications appeared in 1964, when Pistor detailed its use in treating conditions like arthritis and related musculoskeletal pain through precise mesodermal injections.^[11] This work, published in association with his founding of the French Society of Mesotherapy, expanded the method's scope beyond vascular issues to broader rheumatic disorders, establishing a framework for its clinical application.^[2]

Development and Adoption

Following its inception in the mid-20th century, mesotherapy expanded within France through formalized structures and applications beyond initial experimentation. In 1964, Dr. Michel Pistor established the French Society of Mesotherapy to promote and regulate the technique, initially concentrating on pain management for conditions such as rheumatism and vascular disorders, with growing emphasis on sports medicine for athletes' recovery and injury prevention.^[2] This society facilitated research, training, and clinical adoption, laying the groundwork for mesotherapy's integration into French medical practice as a targeted intradermal therapy. By the 1970s and 1980s, mesotherapy began spreading internationally, particularly to neighboring European countries like Italy and Spain, where national societies formed to adapt and localize the method for therapeutic uses in pain relief and rehabilitation. Its adoption extended to Latin America during this period, driven by cultural exchanges in medical practices and the technique's appeal for managing chronic pain in resource-limited settings; for instance, it gained traction in countries such as Brazil and Argentina for musculoskeletal applications.^[2] By the 1990s, mesotherapy's popularity surged in aesthetic medicine across these regions, with practitioners increasingly applying it for localized fat reduction and skin rejuvenation, reflecting a broader shift toward non-invasive cosmetic interventions.^[12] A pivotal milestone occurred in 1987 when the French National Academy of Medicine recognized mesotherapy as an integral part of conventional medicine, affirming its legitimacy and encouraging wider clinical use. This endorsement spurred further global dissemination, including to the United States and Asian countries by the early 2000s, where it was incorporated into sports medicine and dermatology protocols. In 2025, the International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy were published, developed by a multidisciplinary panel from 16 countries under the Italian Society of Mesotherapy; these guidelines standardized protocols for intradermal injections, emphasized evidence-based applications in pain management, rehabilitation, and dermatology, and promoted physician training to ensure safe adoption worldwide.^[13] The 2000s marked a significant evolution in mesotherapy's focus, transitioning from predominantly therapeutic roles to prominent cosmetic applications, such as cellulite treatment and facial revitalization, amid rising demand for minimally invasive aesthetics. This shift was supported by the establishment of dedicated training programs in Europe—through institutions like the French and Italian societies—and in Asia, where academies in countries including South Korea and India began offering certified courses on mesotherapy techniques, fostering professional standardization and broader practitioner accessibility.^[2]

Techniques

Procedure

Mesotherapy procedures begin with a thorough patient assessment to evaluate medical history, identify contraindications such as coagulation disorders or active infections, and determine suitability for treatment. The skin in the target area is then disinfected using an alcohol-free antiseptic to maintain aseptic conditions, while the practitioner wears disposable gloves and prepares sterile, single-use equipment including syringes and fine needles.^[1] Injection sites are selected and mapped based on the specific area being treated, such as outlining regions for localized concerns like cellulite, ensuring personalized placement according to factors like dermal thickness, age, and body region.^[1] The core of the procedure involves microinjections using fine needles, typically 27- to 32-gauge with lengths of 4 mm or 13 mm, inserted at a 30° angle to reach depths of 1-4 mm in the dermis or subcutaneous layer. Common techniques include intradermal point-by-point injections, where 0.02-0.05 mL of solution is administered perpendicularly at 1-2 cm intervals to form small papules, or the nappage method, which employs superficial spraying with a 45° angle and light wrist flick for broader coverage at about 2 mm depth.^[8] These can be performed manually for precision or with mechanical devices like mesoguns to facilitate multiple rapid injections, though multi-injectors are generally discouraged to ensure control and safety.^[14] A standard session entails 10-50 microinjections depending on the treatment area, lasting 15-30 minutes, with the patient positioned comfortably to access the site.^[8] Treatment courses typically involve 4-10 sessions spaced 1-2 weeks apart, adjusted based on clinical response, though acute cases may require fewer.^[14] Following injections, patients are monitored briefly for immediate reactions such as swelling or bruising, with ice packs applied if needed to reduce discomfort.^[8] Post-procedure instructions include avoiding sun exposure and strenuous activities for 24-48 hours, gentle massage of the area in subsequent days to prevent nodules, and documentation of any adverse events in the medical record for follow-up.

Substances and Formulations

Mesotherapy employs a variety of substances categorized into vitamins, minerals, enzymes, hormones, and plant extracts, selected for their targeted physiological effects on skin and subcutaneous tissues.^[15] Vitamins, particularly the B-complex group including thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B8), folic acid (B9), p-aminobenzoic acid (B10), and cyanocobalamin (B12), serve as coenzymes essential for cellular metabolism, energy production, and skin regeneration.^[10] Minerals such as magnesium sulfate contribute to muscle relaxation and enzymatic reactions supporting tissue repair.^[10] Enzymes, including proteolytic types like orgotein, facilitate tissue breakdown and reduce inflammation, while hyaluronidase specifically aids in degrading hyaluronic acid matrices to enhance substance diffusion.^[13]^[16] Hormones, such as thyroxin, are occasionally incorporated to promote fat mobilization, though their use lacks robust clinical support.^[14] Plant extracts, exemplified by centella asiatica, stimulate collagen synthesis and improve vascular integrity for enhanced skin firmness.^[15] Custom formulations in mesotherapy, often termed "cocktails," combine these substances in tailored mixtures to address specific indications, such as lipolytic blends containing caffeine, artichoke extract, and yohimbine for fat reduction.^[17] A representative example is the NCTF135HA cocktail, comprising 53 ingredients including hyaluronic acid, amino acids, coenzymes, nucleotides, and antioxidants, designed to replenish substrates depleted in aging skin.^[10] These polycomponent preparations must adhere to pharmacopeial standards for stability and biocompatibility to ensure therapeutic efficacy.^[13] Preparation of mesotherapy substances occurs in licensed pharmacies under strict aseptic conditions, utilizing double filtration sterilization to preserve heat-sensitive components like vitamins without compromising bioactivity.^[10] Dosages are precisely controlled, with typical volumes of 0.1 to 0.2 mL administered per injection site to minimize systemic absorption while maximizing local delivery.^[13] The evolution of mesotherapy formulations reflects a transition from homeopathic dilutions to evidence-based actives, as outlined in the 2025 International Consensus Guidelines, which prioritize single-agent or well-studied combinations supported by clinical trials for safety and efficacy.^[13]

Applications

Cosmetic Uses

Mesotherapy is commonly employed off-label in cosmetic treatments for targeted fat reduction, particularly in areas of localized adiposity such as the abdomen and thighs, where intradermal injections of lipolytic agents like phosphatidylcholine and deoxycholate are administered to disrupt fat cells and promote localized lipolysis.^[3] However, scientific evidence is limited by small studies, and it lacks endorsement from recent international consensus guidelines; in the United States, such injections are not FDA-approved and have been associated with adverse effects.^[3]^[13]^[6] These agents aim to reduce subcutaneous fat deposits without invasive surgery, often requiring multiple sessions to achieve contouring effects, though the procedure is typically well-tolerated with minimal downtime.^[3] In skin rejuvenation, mesotherapy utilizes hyaluronic acid formulations, often combined with antioxidants, to enhance facial and neck aesthetics by improving skin hydration, elasticity, and wrinkle appearance through deep dermal delivery that stimulates collagen production and tissue repair.^[18] Non-cross-linked hyaluronic acid is injected via techniques like serial micropuncture or nappage, typically in 1-6 sessions spaced weekly to bimonthly, resulting in revitalized skin texture and reduced signs of photoaging.^[18] This approach is favored for its minimally invasive nature, providing gradual improvements in skin quality over several months with periodic maintenance.^[18] For cellulite treatment, mesotherapy targets dimpled skin on the buttocks and legs by injecting substances that enhance microcirculation, reduce fluid retention, and promote collagen synthesis, thereby smoothing the skin's uneven surface and decreasing hypodermal thickness.^[19] Clinical assessments using ultrasound and scales like Nürnberger-Müller have shown reductions in cellulite severity following multiple intradermal sessions, with improvements in thigh circumference and dermal-hypodermal junction regularity.^[19] Mesotherapy for hair restoration involves scalp injections of growth factors and bioactive agents to combat androgenetic alopecia by stimulating dormant hair follicles, prolonging the anagen phase, and increasing hair density.^[20] Formulations may include autologous suspensions or combinations with minoxidil to enhance follicular nutrition and regeneration, administered in varied regimens across studies to yield visible regrowth.^[20] Mesotherapy has also been applied in dermatological conditions such as melasma (particularly refractory cases), acne, and keloids through targeted intralesional injections to improve pigmentation, reduce inflammation, and minimize scarring, as endorsed by 2025 international consensus guidelines.^[13]

Medical Uses

Mesotherapy has been employed in pain management for various musculoskeletal conditions, including arthritis and sports injuries, through the intradermal or subcutaneous injection of anti-inflammatory agents, anesthetics, and muscle relaxants directly into affected areas. This approach allows for localized drug delivery, potentially reducing systemic side effects while providing rapid pain relief and improved mobility in conditions such as low back pain, knee osteoarthritis, and neck pain. Clinical evidence indicates that mesotherapy is well-tolerated and effective for both acute and chronic musculoskeletal pain, often outperforming oral therapies in targeted symptom reduction.^[21]^[22]^[13] In sports medicine, mesotherapy supports recovery from injuries like patellar tendonitis, Achilles tendonitis, and muscle contractures by injecting anti-inflammatory and regenerative substances to alleviate localized pain and restore joint function, with evidence from clinical studies showing improved outcomes.^[13] In vascular disorders, mesotherapy targets conditions like chronic venous insufficiency and associated edema by administering vasodilators and antithrombotic substances to enhance circulation and alleviate symptoms such as swelling and pain. For instance, intradermal injections of agents like lymdiaral have shown promise in pilot studies for reducing fibrosclerotic edema damage in chronic venous insufficiency, serving as an adjunct to standard compression therapy. Recent consensus guidelines endorse its use in painful edematous fibrosclerotic syndrome and venous disease management, emphasizing its role in preventing complications through localized pharmacotherapy.^[23]^[24]^[13] Neurological applications of mesotherapy include relief from cervicobrachialgia and fibromyalgia-associated neck pain via nerve-targeted injections of analgesics and anti-inflammatory compounds, which modulate local pain pathways potentially involving endorphin release and glial cell activity. Studies have demonstrated its efficacy in treating these conditions, with improvements in pain intensity and quality of life comparable to systemic treatments but with fewer adverse effects.^[13] Additionally, mesotherapy supports wound healing acceleration and scar reduction in clinical contexts by delivering regenerative substances like growth factors or anti-fibrotic agents to promote tissue repair and minimize scarring. Randomized trials have evaluated its impact on facial scar improvement, showing enhanced healing outcomes when combined with microencapsulated recombinant proteins. The 2025 international consensus guidelines highlight mesotherapy's applicability in diverse clinical settings for such indications, though evidence remains emerging and calls for further standardization.^[25]^[13]

Efficacy and Evidence

Clinical Studies

Clinical studies on mesotherapy have primarily focused on its applications in pain management, cosmetic fat reduction, and dermatological conditions, with varying levels of evidence derived from randomized controlled trials (RCTs) and systematic reviews. A 2021 systematic review and meta-analysis of eight RCTs involving musculoskeletal disorders found moderate evidence supporting mesotherapy's efficacy for localized pain relief and functional improvement, demonstrating superior outcomes compared to systemic therapies, with a statistically significant reduction in pain scores (mean difference -1.45 on VAS scale) and no serious adverse events reported.^[26] This review highlighted mesotherapy's role in conditions like chronic low back pain and shoulder periarthritis, where intradermal injections of analgesics and anti-inflammatories provided targeted relief.^[26] In contrast, evidence for mesotherapy in cosmetic fat reduction remains limited. A 2013 systematic review of available studies on localized adiposity treatments concluded that while some small-scale trials reported modest reductions in fat thickness (e.g., up to 2 cm in abdominal circumference after multiple sessions), the overall support was weak due to heterogeneous methodologies and short follow-up periods, with no large-scale RCTs confirming long-term efficacy.^[3] Recent developments include the 2025 International Consensus Guidelines on the safe and evidence-based use of mesotherapy in dermatology and rheumatology, which cite multiple RCTs affirming its safety profile and moderate efficacy for localized musculoskeletal pain and certain skin conditions, recommending standardized protocols to enhance reproducibility.^[27] Ongoing research continues to explore its potential in hair regrowth for androgenetic alopecia, with preliminary data suggesting improved hair density in small cohorts without significant side effects. Methodological challenges persist across studies, including small sample sizes (often n<50), inadequate blinding, and infrequent use of placebo controls, which may inflate perceived benefits in aesthetic applications.^[3] Placebo effects have been particularly noted in trials for cosmetic outcomes, where subjective improvements in appearance were reported without objective volumetric changes.^[3] Overall, the evidence level is promising for mesotherapy in localized pain management, supported by systematic reviews, but insufficient for broad cosmetic claims, as emphasized in multiple high-quality analyses lacking robust, long-term data.^[26]^[3]

Regulatory Status

In the United States, mesotherapy is not approved by the Food and Drug Administration (FDA) for cosmetic or therapeutic applications and is classified as an off-label use. The FDA has specifically warned against unproven fat-dissolving injections associated with mesotherapy, citing risks of adverse reactions from non-approved substances.^[6]^[16]^[28] In Europe, mesotherapy is recognized as a legitimate medical procedure in France, its country of origin, and Italy, though with strict oversight on indications such as fat reduction, which faced temporary prohibitions before regulatory adjustments. Italian law mandates that intradermal injections be performed exclusively by qualified physicians, as affirmed by court judgments. Under broader EU pharmaceutical regulations, mesotherapy requires administration by licensed practitioners and the use of sterile, properly compounded substances to ensure compliance with good manufacturing practices.^[29]^[2]^[13] Mesotherapy is widely practiced for aesthetic uses in Brazil and Mexico, subject to oversight by the Agência Nacional de Vigilância Sanitária (ANVISA) and the Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) on injectables and aesthetic procedures, supporting its integration into cosmetic practices in these markets.^[30]^[31]^[13] Regulatory approaches in Asia remain varied across countries, with procedures often subject to national health authority approvals for injectables, and ongoing efforts toward standardization.^[13] The 2025 International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy, developed by a multidisciplinary panel of experts from 16 countries, advocate for evidence-based protocols, off-label use only with robust clinical support, and mandatory practitioner certification to promote global harmonization and safety.^[13]

Safety and Criticism

Risks and Side Effects

Mesotherapy, while generally considered a low-risk procedure when performed correctly, is associated with a range of potential adverse effects, primarily due to the invasive nature of multiple injections and the variability of injected substances.^[32] Common side effects include bruising, swelling, pain at the injection sites, and temporary pigmentation changes such as dark patches or redness, which typically resolve within 1 to 7 days without intervention.^[14]^[33] These reactions are common, stemming from the mechanical trauma of needle insertion and the inflammatory response to the injected agents.^[33] More serious risks encompass infections arising from non-sterile needles or contaminated substances, allergic reactions to the injected materials, and embolism resulting from inadvertent vascular injection.^[34]^[35] Infections, including outbreaks of nontuberculous mycobacterial subcutaneous infections, have been documented in clinical settings where aseptic protocols were inadequate. More recent outbreaks, such as a 2023 cluster of Mycobacterium abscessus infections linked to mesotherapy in a beauty center, underscore the ongoing risks from inadequate sterilization.^[36]^[37] Allergic responses may manifest as immediate or delayed hypersensitivity, particularly to components like lecithin, while embolic events, such as those seen in Nicolau syndrome, involve drug-induced occlusion of cutaneous arteries leading to livedoid dermatitis.^[16]^[35] Rare complications include skin necrosis, granulomas, and panniculitis, often linked to improper formulations or off-label use of substances, with elevated risks in cosmetic fat-dissolving procedures due to deeper injections and lipolytic agents.^[38]^[39] Necrosis may present as tissue death with eschar formation, while granulomas form as foreign body reactions to injected particles, occurring at rates as low as 0.04% for hyaluronic acid-based formulations but higher with unapproved mixtures.^[40]^[41] Adherence to 2025 international consensus guidelines significantly mitigates these risks through the use of sterile disposable equipment, hypoallergenic and approved injectable agents, rigorous aseptic techniques, and structured post-care protocols including patient monitoring and avoidance of anti-inflammatory medications pre-treatment.^[13] These measures, including informed consent and documentation of procedures, promote safety across clinical settings and reduce the incidence of adverse events when followed by qualified practitioners.^[27]

Criticisms

Mesotherapy has faced significant criticism for its lack of standardization, as practitioners often use custom "cocktails" of ingredients without established protocols for composition, dosage, or administration techniques, leading to inconsistent outcomes and potential variability in results.^[42] This variability is compounded by the arbitrary selection of compounds, such as vitamins, enzymes, hormones, and herbal extracts, whose pharmacodynamics in intradermal or subcutaneous delivery remain poorly understood.^[43] Critics highlight substantial evidence gaps, with accusations of hype in cosmetic applications despite a paucity of robust randomized controlled trials (RCTs) supporting its efficacy for conditions like cellulite reduction or skin rejuvenation.^[44] The U.S. Food and Drug Administration (FDA) has issued warnings since the 2000s against unproven claims for mesotherapy and related injection lipolysis procedures, noting that none of the formulations are approved for fat dissolution or aesthetic uses, and emphasizing the absence of scientific validation for advertised benefits. Ethical concerns arise from the potential for quackery, particularly in unregulated settings like spas where non-physicians may overpromote mesotherapy without adequate medical oversight, exploiting patients with unsubstantiated promises of non-invasive fat loss or rejuvenation.^[45] Such practices raise issues of informed consent and patient exploitation, as the technique's promotion often relies on anecdotal testimonials rather than verifiable data, undermining trust in legitimate dermatological care.^[43] Professional opinions remain divided: while the French Society of Mesotherapy endorses its use for pain management and certain localized conditions, viewing it as a valid minimally invasive approach, major dermatological bodies like the American Academy of Dermatology dismiss it as unnecessary and ineffective, particularly for cosmetic indications, due to insufficient evidence of benefits outweighing risks.^[46]^[47]

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[37]
Ischemic colitis after mesotherapy combined with anti-obesity ... - NIH
However, there is a tendency to disregard their various adverse effects. Adverse effects of mesotherapy include bruising, edema, skin necrosis, abdominal ...
[38]
Mesotherapy: Safety profile and management of complications
Aug 24, 2019 · Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes.Abstract · INTRODUCTION · RESULTS · CONCLUSIONS
[39]
Mesotherapy-Induced Cutaneous Foreign Body-Type ... - NIH
Apr 3, 2023 · Mesotherapy induces infectious and noninfectious complications. ... necrosis, cyst formation, ulcer formation and alopecia.Missing: embolism | Show results with:embolism
[40]
Infected Skin Necrosis after Mesotherapy.
Mar 1, 2008 · The infection finding was swelling, reddish to purple color change and bullae formation. As time goes by, skin necrosis and eschar formation ...Missing: embolism | Show results with:embolism
[41]
Concerns about drug efficacy, safety surround mesotherapy
She notes that there is a lack of standardization in these tailor-made cocktails. "For male pattern baldness, cocktails can include finasteride, T3 ...
[42]
Position paper on mesotherapy
This position paper has examined the available evidence and finds that acceptable scientific evidence for its effectiveness and safety is lacking.
[43]
A Cautious Look at Mesotherapy for Fat Reduction - Quackwatch
Apr 21, 2008 · Quackwatch. Your Guide to Quackery, Health Fraud, and Intelligent Decisions ... dermatologists in the United States have warned against ...
[44]
Mesotherapy Not Proven As a Safe Alternative to Liposuction
Nov 29, 2007 · Touted as a nonsurgical alternative to liposuction, mesotherapy involves injecting medications and plant extracts into layers of fat and ...
[45]
SOCIETE FRANCAISE DE MESOTHERAPIE DEFINITION - SOINS ...
La MÉSOTHÉRAPIE est indiquée surtout : EN RHUMATOLOGIE · La MÉSOTHÉRAPIE est un traitement de la douleur dans : l'ARTHROSE, LES TENDINOPATHIES · En MÉDECINE DU ...En pratique · Hygiène · DIU de Mesotherapie · Matériel
[46]
Cellulite treatments: What really works?
Mesotherapy. During this procedure, you receive a series of injections in the area(s) with cellulite. Different substances are injected into the area ...