Fact-checked by Grok 2 weeks ago

Monobenzone

Monobenzone, chemically known as monobenzyl ether of hydroquinone (MBEH), is a potent topical depigmenting agent with the molecular formula C₁₃H₁₂O₂, primarily used to induce permanent skin lightening in patients with extensive vitiligo affecting more than 50% of the body surface area.^[1]^[2] By acting as a tyrosinase inhibitor and inducing an immune response that destroys melanocytes, it causes irreversible loss of these pigment-producing cells, allowing the depigmented areas of vitiligo to blend evenly with surrounding skin through uniform lightening of unaffected regions.^[1]^[3]^[4] Approved by the U.S. Food and Drug Administration (FDA) for medical depigmentation, monobenzone is available as a 20% topical cream formulation, which may be compounded since the brand Benoquin is discontinued, and is prescribed exclusively for severe, widespread vitiligo cases where repigmentation therapies have failed or are unsuitable.^[5]^[6]^[7] Application involves twice-daily topical use on pigmented skin, typically requiring 1–4 months for initial effects and up to a year for full depigmentation, after which maintenance applications may be needed to prevent uneven recoloring.^[2]^[6] As a dermatologic drug, monobenzone acts as a selective allergen that triggers immune-mediated melanocyte loss, distinguishing it from milder bleaching agents like hydroquinone, which are unsuitable for vitiligo due to their reversible effects.^[1]^[8] However, its use demands caution, as it can cause severe irritation, allergic reactions, or unintended depigmentation if applied beyond vitiligo-affected areas, and it is contraindicated in patients with hypersensitivity or incomplete vitiligo involvement.^[2]^[9]^[7] Emerging research also explores its potential beyond dermatology, including anti-melanoma properties through inhibition of histone demethylase KDM1A, though these applications remain investigational.^[10]

Chemical Properties

Structure and Formula

Monobenzone has the molecular formula C_{13}H_{12}O_2.^[1] Its IUPAC name is 4-(benzyloxy)phenol.^[11] Common alternative names include monobenzyl ether of hydroquinone (MBEH) and 4-benzyloxyphenol.^[11] These designations reflect its classification as an organic compound in the phenol family.^[12] Structurally, monobenzone is a phenol derivative derived from hydroquinone, where one of the two hydroxyl groups on the 1,4-dihydroxybenzene backbone is etherified with a benzyl group (-CH_2C_6H_5).^[12] This results in a monosubstituted ether form, featuring a phenolic benzene ring with a free hydroxyl group para to an ether oxygen connected via a methylene bridge to an unsubstituted phenyl ring.^[1] The key ether linkage (-O-CH_2-) between the two aromatic systems imparts distinct chemical properties compared to di-substituted hydroquinone ethers.^[11]

Physical and Chemical Characteristics

Monobenzone is a white, almost tasteless crystalline powder at room temperature.^[1] This compound exhibits good solubility in alcohol but is practically insoluble in water, which influences its handling and formulation in non-aqueous media.^[1] The melting point of monobenzone ranges from 119 to 120 °C, indicating its thermal stability up to moderate temperatures before transitioning to a liquid state. Under standard ambient conditions, monobenzone remains chemically stable, with no significant decomposition observed during typical storage. However, it demonstrates reactivity with strong oxidizing agents, potentially leading to oxidative degradation if exposed to such substances.^[13] As a phenolic ether, its ether linkage contributes to overall chemical inertness in neutral environments, though it may undergo cleavage in the presence of harsh conditions.

Medical Uses

Depigmentation Therapy for Vitiligo

Monobenzone is indicated for the permanent depigmentation of normally pigmented skin in patients with extensive vitiligo affecting more than 50% of the body surface area (BSA), where the goal is to achieve a uniform skin tone by lightening the remaining pigmented areas to match the depigmented patches.^[7]^[14]^[15] This therapy is particularly suitable for cases of vitiligo universalis or widespread stable disease that has not responded to repigmentation treatments, such as topical corticosteroids or phototherapy.^[4] Patient selection emphasizes individuals with treatment-resistant vitiligo and requires assessment of psychological readiness, including screening for realistic expectations and ability to cope with the permanent alteration in skin color and potential social implications.^[16]^[14] The standard application involves a topical cream formulation at a 20% concentration, such as Benoquin, applied twice daily to the hyperpigmented skin surrounding vitiliginous areas and any desired treatment zones.^[7]^[17] Patients are instructed to rub the cream gently into the skin until absorbed, avoiding sun exposure on treated areas and using broad-spectrum sunscreen to prevent uneven results, with treatment progressing gradually to cover all targeted regions.^[14] Higher concentrations, such as 40%, have been evaluated in clinical trials but are not standard due to increased irritation risk.^[17] Initial depigmentation typically becomes noticeable after 1–4 months of consistent use, with full effects requiring 6–12 months or longer, up to 1–3 years in some cases, after which the process is irreversible due to permanent destruction of melanocytes.^[18]^[19] Once initiated, discontinuation does not reverse the changes, necessitating lifelong sun protection to maintain uniformity.^[7] Clinical outcomes demonstrate high efficacy, with studies reporting successful depigmentation in 80–90% of appropriately selected patients, achieving uniform skin tone when adherence is maintained; for instance, one analysis found 84% of severe vitiligo cases showed depigmentation, with 44% reaching complete uniformity. Recent 2024 research confirms depigmentation efficacy with 60-90% reduction in patches after 3 months but notes increased oxidative stress and potential systemic effects.^[20]^[17]^[21] Success depends on the extent of initial involvement and patient compliance, with monitoring via photography and BSA assessments recommended every 1–2 months to guide progression.^[4]

Off-Label and Other Uses

Monobenzone has been misused cosmetically for general skin lightening and bleaching, particularly in attempts to treat conditions like melasma, despite lacking regulatory approval for such purposes and carrying significant risks of permanent depigmentation and chemical vitiligo.^[22] This illicit application often occurs through unregulated topical formulations, leading to uneven skin tone and long-term complications that outweigh any temporary aesthetic benefits.^[23] In limited clinical contexts, monobenzone has been explored off-label for treating post-inflammatory hyperpigmentation, especially in refractory cases unresponsive to milder agents like hydroquinone.^[24] Case reports and early evaluations indicate potential efficacy in reducing stubborn pigmented lesions, but its use is constrained by the drug's irreversible effects and the scarcity of controlled studies supporting broader application.^[25] Experimentally, monobenzone serves as a tool in dermatological research for inducing melanocyte ablation and studying autoimmunity, particularly in models of vitiligo and melanoma immunotherapy.^[26] Its ability to haptenate tyrosinase and trigger T-cell responses against pigmented cells has been investigated for potential therapeutic modulation of melanocyte destruction, though clinical translation remains investigational.^[27] Preliminary research as of 2025 has investigated monobenzone for psoriasis treatment, showing potential therapeutic effects in early studies.^[28] Historically, monobenzone exposure in the rubber industry caused accidental depigmentation among workers, resulting in occupational vitiligo-like conditions from contact with cured rubber products containing the compound as an antioxidant.^[29] This led to widespread cases of contact leukoderma in the mid-20th century, prompting its removal from many industrial formulations and highlighting the compound's potent depigmenting hazards beyond medical use.^[30] Due to the discontinuation of some commercial formulations like Benoquin in certain markets, monobenzone is often prepared as compounded creams in specialized pharmacies to meet custom patient needs, such as varying concentrations for targeted depigmentation.^[31] This approach allows for tailored application but requires oversight to ensure safety and efficacy in off-label scenarios.

Pharmacology

Mechanism of Action

Monobenzone primarily acts as a cytotoxic agent toward melanocytes, the pigment-producing cells in the skin, resulting in their destruction and a permanent loss of melanin production.^[12]^[7] This depigmentation occurs through selective targeting of melanocytes in normally pigmented areas, where the compound interacts with active melanin synthesis pathways, leading to hypopigmentation that typically develops over 1 to 4 months of topical application.^[7]^[3] Several proposed biochemical pathways contribute to this effect. Monobenzone increases the excretion of melanin from melanocytes, reducing pigment accumulation in the skin.^[12]^[7] It also generates reactive oxygen species (ROS) within melanocytes, inducing oxidative stress and cellular damage that promotes cell death.^[3] Additionally, monobenzone inhibits tyrosinase, the rate-limiting enzyme in melanin biosynthesis, by forming reactive quinone intermediates that haptenate melanosomal proteins, further disrupting pigment production.^[12]^[3] The formation of these quinone-haptens, particularly with tyrosinase, increases the immunogenicity of melanocytes, triggering a T-cell-mediated autoimmune response that contributes to the selective destruction of pigment cells and ensures the permanence of depigmentation.^[32]^[26] The irreversibility of monobenzone's depigmentation stems from the complete ablation of melanocytes, as histological examinations post-treatment reveal an absence of identifiable melanocytes in the epidermis, in contrast to reversible agents like hydroquinone that merely suppress melanin synthesis temporarily without cell destruction.^[7]^[12] In vitro studies support these mechanisms, demonstrating that exposure of cultured human melanocytes to monobenzone triggers oxidative damage, ROS production, and subsequent necrotic or apoptotic cell death, often marked by caspase activation and melanosome autophagy.^[3]^[26]

Pharmacokinetics

Monobenzone, applied topically as a 20% cream, demonstrates poor systemic absorption through intact skin, resulting in minimal percutaneous uptake and primarily local effects at the site of application. This limited absorption profile contributes to its targeted depigmenting action without widespread systemic exposure under normal use conditions.^[12]^[33] Distribution of monobenzone is largely confined to the treated skin area and adjacent dermal layers, where it interacts with melanocytes to induce depigmentation. No significant plasma concentrations are typically observed, reflecting its localized pharmacokinetics and low bioavailability beyond the application site. However, application to extensive skin surfaces or regions prone to higher absorption, such as inflamed or compromised barriers, may increase the risk of systemic uptake.^[7]^[34] In the skin, monobenzone undergoes metabolism primarily through enzymatic oxidation by tyrosinase within melanocytes, generating reactive ortho-quinone species that form haptens and contribute to melanocyte cytotoxicity. This local biotransformation supports the drug's depigmenting mechanism without evidence of extensive hepatic involvement. Detailed pathways beyond tyrosinase-mediated oxidation remain underexplored.^[35]^[36] Elimination details for monobenzone are not well-characterized due to its topical administration and negligible systemic levels; any absorbed fraction is presumed to be metabolized locally and excreted as unidentified metabolites, though specific data are lacking. The plasma half-life has not been established, consistent with the drug's minimal circulation.^[12]

Adverse Effects

Common Side Effects

The most frequently reported adverse reactions to monobenzone are mild, localized skin responses at the application site, including irritation characterized by redness (erythema), itching (pruritus), and dryness (xerosis). These effects arise due to the topical nature of the depigmenting agent and are generally transient, though they can cause discomfort during early treatment phases.^[37]^[38] In randomized clinical trials evaluating monobenzone creams at concentrations of 20% and 40% for vitiligo depigmentation, skin irritation occurred in approximately 57% of patients treated with the 20% formulation (36.8% mild and 20.1% moderate to severe) and up to 85% with the 40% formulation (25% mild and 60% moderate to severe). Cracking, scaling, or peeling of the treated skin may accompany these symptoms, often linked to the drug's cytotoxic impact on melanocytes and surrounding tissue. Mild burning or stinging sensations are also prevalent, particularly in the first few weeks of application, affecting a notable proportion of users but typically diminishing as tolerance develops.^[39]^[37] Allergic contact dermatitis represents a less common but notable sensitization reaction, potentially resulting in an eczematous rash or heightened inflammatory response upon repeated exposure. Case reports document instances of contact hypersensitivity, underscoring the need for patch testing in susceptible individuals, though overall incidence remains low in clinical settings.^[40]^[41] Management of these common side effects focuses on supportive measures to enhance tolerability without interrupting therapy. Strategies include reducing application frequency (e.g., from twice daily to once nightly or alternate days), incorporating emollients or moisturizers to combat dryness, and applying low-potency topical corticosteroids for inflammation. Cold compresses can alleviate acute burning or edema. In most cases, these reactions subside with continued use, and discontinuation due to side effects is infrequent, occurring in fewer than 10% of trial participants. Patients should monitor for persistence or worsening and consult a dermatologist promptly.^[39]^[37]

Serious Risks and Contraindications

Monobenzone induces permanent depigmentation by destroying melanocytes in treated areas, rendering the skin color loss irreversible and often requiring months to fully manifest. This effect can unpredictably spread to untreated distant sites, such as the face, genitals, or other body regions, leading to irregular and excessive hypopigmentation that may be cosmetically distressing and permanent.^[7]^[18] Application near the eyes poses significant risks, including unintended permanent depigmentation of periorbital and distant sites, as well as reported ocular effects such as corneal pigment deposition and conjunctival melanosis. To mitigate this, monobenzone should never be applied to eyelids or periocular regions. Contraindications include known hypersensitivity to hydroquinone derivatives like monobenzone, as well as active inflammatory skin conditions or infections, which may exacerbate local reactions or interfere with safe application. It is also contraindicated in children under 12 years due to unestablished safety and efficacy, and during pregnancy (FDA Category C), where it should only be used if benefits clearly outweigh potential fetal risks, as no adequate reproduction studies exist.^[7]^[18]^[42]^[43] Long-term use heightens UV sensitivity in depigmented skin, necessitating lifelong strict sun protection measures like broad-spectrum SPF 30+ sunscreen and protective clothing to prevent sunburn, premature aging, or skin cancer. The profound alteration in appearance from widespread depigmentation can have notable psychological impacts, including social discomfort or adjustment challenges, though some patients report improved quality of life post-therapy. Regular dermatological monitoring is essential throughout treatment and maintenance to detect over-depigmentation early, adjust application frequency, and ensure patient adherence to protective protocols.^[7]^[18]^[44] A 2024 study found that monobenzone treatment significantly increased oxidative stress markers (total oxidative stress and malondialdehyde) and proinflammatory cytokines (IL-1β and IL-18), suggesting potential contributions to systemic inflammation and long-term health issues such as organ failures, although no changes in organ function were observed in the study cohort and further research is required.^[45]

History

Discovery and Development

The depigmenting effects of monobenzone, chemically known as monobenzyl ether of hydroquinone, were first identified accidentally in 1939 through occupational exposure among workers in a rubber processing facility. Dermatologists E. A. Oliver, L. Schwartz, and L. H. Warren observed patchy depigmentation on the hands of approximately 50% of affected employees who handled rubber containing monobenzone as an antioxidant, with patch testing confirming the compound's role in inducing leukoderma.^[46] This incident highlighted monobenzone's potent skin-lightening properties, initially viewed as an industrial hazard rather than a potential therapeutic tool.^[29] In the 1940s, early laboratory research began to explore monobenzone's depigmenting potential, building on the occupational observations. Researchers C. R. Denton, A. B. Lerner, and T. B. Fitzpatrick conducted pivotal studies demonstrating that monobenzone, alongside hydroquinone, inhibited melanin formation by blocking tyrosinase activity in animal models such as guinea pigs and cats, establishing its selective action on melanocytes.^[47] These findings positioned monobenzone as a candidate for treating hyperpigmentary conditions, though concerns over its irreversible effects prompted cautious evaluation. Fitzpatrick, a leading dermatologist, played a key role in advancing phenolic depigmenting agents like monobenzone through these investigations, which laid the groundwork for clinical translation.48268-5/pdf) By the 1950s, clinical trials marked a significant development milestone, confirming monobenzone's efficacy for intentional depigmentation in patients with extensive vitiligo. Trials demonstrated that topical application achieved uniform skin lightening by progressively destroying melanocytes in remaining pigmented areas, offering a viable option for those with over 50% body involvement where repigmentation was impractical.^[48] This era saw monobenzone transition from an industrial chemical implicated in accidental vitiligo to a targeted medical agent, selected over other compounds for its reliability in achieving complete depigmentation, albeit with acknowledgment of its permanent nature.^[49]

Regulatory History

Monobenzone, marketed as Benoquin Cream 20%, received approval from the United States Food and Drug Administration (FDA) in 1952 for the permanent depigmentation of extensive vitiligo in patients with greater than 50% body surface area involvement, establishing it as a prescription-only medication restricted to final-stage treatment under dermatological supervision.^[4] The formulation was specifically indicated for topical application to depigment remaining normally pigmented skin areas, aiming to achieve a uniform skin tone, and was never approved for cosmetic skin lightening or over-the-counter use.^[7] In 2003, the FDA revised the labeling for Benoquin to strengthen warnings regarding its irreversible effects, including a prominent boxed warning stating that the drug is destructive to melanin and may cause permanent depigmentation, with potential risks such as exogenous ochronosis and heightened sensitivity to sunlight in treated areas.^[7] These updates emphasized the need for patient counseling on the therapy's permanence, prohibiting its use on sun-exposed areas without protection, and contraindicating it for individuals under 12 years or those with hypersensitivity to hydroquinone derivatives.^[7] Internationally, monobenzone holds varying regulatory statuses, with approval in Canada for depigmentation therapy in vitiligo under similar prescription-only restrictions as the FDA, though it is prohibited in cosmetic products due to safety concerns.^[50]^[51] In the European Union, it has been banned for use in cosmetics since 2001 owing to risks of irreversible depigmentation and potential carcinogenicity, limiting its availability to medical prescriptions in select member states for vitiligo management.^[18] In contrast, countries like India have banned monobenzone-containing products for cosmetic skin lightening since the late 1990s, following reports of misuse leading to chemical vitiligo and other adverse effects, with enforcement focusing on unregulated imports and sales. Post-marketing surveillance in the 2010s highlighted instances of misuse for unauthorized skin bleaching, prompting regulatory agencies, including the FDA, to issue warnings against over-the-counter availability and emphasize its niche role in vitiligo to prevent off-label abuse and associated complications like uneven pigmentation and increased skin cancer risk.^[52] These efforts underscored the drug's limited therapeutic window, with surveillance data reinforcing restrictions to supervised medical use only.^[53] Currently, Benoquin is no longer commercially marketed in the United States, leading to its preparation through compounding pharmacies to meet patient-specific needs, such as custom concentrations up to 40% in creams or ointments for vitiligo depigmentation.^[52] This shift has resulted in no generic competition, as the drug's specialized, low-volume application discourages large-scale manufacturing, ensuring availability remains tied to prescription compounding under regulatory oversight.^[54]^[55]

References

[1]
Monobenzone | C13H12O2 | CID 7638 - PubChem
It is used as a topical drug for medical depigmentation. It has a role as a melanin synthesis inhibitor, a dermatologic drug and an allergen. It is functionally ...
[2]
Monobenzone topical Uses, Side Effects & Warnings - Drugs.com
Monobenzone topical (for the skin) is used to permanently lighten skin in people with vitiligo. Depigmenting darker skin around the areas of vitiligo helps ...What Is The Most Important... · What Should I Discuss With... · How Should I Use Monobenzone...
[3]
Successful Treatment of Extensive Vitiligo with Monobenzone - PMC
7 Monobenzone (monobenzyl ether of hydroquinone, MBEH) is usually the treatment of choice of depigmentation therapy for severe cases of vitiligo, and MBEH is ...
[4]
Identification of Monobenzone as a Novel Potential Anti-Acute ... - NIH
Sep 27, 2022 · Monobenzone is an FDA-approved depigmenting agent for vitiligo patients. In this study, we demonstrate that monobenzone is a potent inhibitor of ...
[5]
Benoquin: Package Insert / Prescribing Information - Drugs.com
Mar 24, 2025 · Benoquin Cream 20% is a potent depigmenting agent, not a mild cosmetic bleach. Do not use except for final depigmentation in extensive vitiligo.Benoquin Description · Benoquin - Clinical... · Indications And Usage For...
[6]
TOPICAL APPLICATION OF BLEACHING PHENOLS; IN VIVO ... - NIH
Monobenzyl ether of hydroquinone or MBEH is currently in use as an FDA approved agent to induce depigmentation in vitiligo patients [1]. Depigmenting qualities ...<|control11|><|separator|>
[7]
Monobenzone Topical Side Effects: Common, Severe, Long Term
Do not use monobenzone on any areas that are not affected by vitiligo. Monobenzone is not for treating freckles, café-au-lait spots, sun damage, melanoma, ...
[8]
Monobenzone, a Novel and Potent KDM1A Inhibitor, Suppresses ...
Apr 15, 2021 · Monobenzone is a potent skin-bleaching agent in melanoma patients (van den Boorn et al., 2011). In 2018, it was also reported that monobenzone ...
[9]
Monobenzone | 103-16-2 - ChemicalBook
4-(Benzyloxy)phenol, also called monobenzone and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5 ...Missing: IUPAC | Show results with:IUPAC
[10]
Monobenzone: Uses, Interactions, Mechanism of Action - DrugBank
Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, ...
[11]
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2156828.htm
[12]
[PDF] benoquin® cream 20% - accessdata.fda.gov
Benoquin Cream 20% is indicated for final depigmentation in extensive Vitiligo. Benoquin Cream 20% is applied topically to permanently depigment normal skin ...Missing: selection | Show results with:selection
[13]
Depigmentation therapy for vitiligo - DermNet
Depigmentation therapy may be considered in the management of treatment-resistant vitiligo affecting more than 50% of the body surface area or affecting ...
[14]
Monobenzone - an overview | ScienceDirect Topics
Monobenzone, the monobenzyl ether of hydroquinone, is a special topical phenolic agent that is indicated only for the final depigmentation of disfiguring ...
[15]
[PDF] Vitiligo Patients Seeking Depigmentation Therapy: A Case Report ...
We report the case of a 24-year-old man with vitiligo who sought depigmentation ther- apy and withheld crucial information regarding his psychiatric and ...Missing: method | Show results with:method
[16]
(PDF) Monobenzyl ether of hydroquinone 20 and 40% cream in ...
Aug 7, 2025 · Patients' responses were assessed bimonthly over 1 year or till complete depigmentation was attained through photography, point counting, and ...
[17]
Depigmentation therapies in vitiligo
Gradually, lightening of skin occurs over a period of 4 to 12 months. Depigmentation induced by MBEH is usually irreversible and histologically associated with ...Missing: criteria | Show results with:criteria
[18]
Depigmentation Therapies in Vitiligo - IntechOpen
The depigmentation process is a gradual one and can take anywhere between 1 and 3 years. In the author's experience, those who have undergone depigmentation are ...Missing: criteria | Show results with:criteria
[19]
Depigmentation - Global Vitiligo Foundation
In a clinical study of patients with severe vitiligo, monobenzone 20% produced depigmentation in 84% of patients, with complete depigmentation in 44%.
[20]
https://globalvitiligofoundation.org/depigmentation/
[21]
https://pmc.ncbi.nlm.nih.gov/articles/PMC11626302/
[22]
Evaluation of Monobenzone - JAMA Network
As yet no compound has been found which will adequately lighten hyperpigmented skin. The original reports of Oliver and associates that monobenzone caused ...
[23]
Evaluation of monobenzone. - Semantic Scholar
1975. TLDR. The formula was therapeutically effective in treatment of melasma, ephelides, and postinflammatory hyperpigmentation and Senile lentigines were ...
[24]
Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell ...
We show monobenzone to increase melanocyte and melanoma cell immunogenicity by forming quinone-haptens to the tyrosinase protein.
[25]
Monobenzone as Immunotherapy for Melanoma
Aug 5, 2011 · Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy.Missing: experimental | Show results with:experimental
[26]
Chemical-induced Vitiligo - PMC - NIH
Depigmentation was also reported following exposure to other products that contained MBEH, primarily by items made of rubber. MBEH has been removed from ...
[27]
Contact leukoderma - DermNet
Monobenzylether of hydroquinone (MBH) was the first identified chemical to cause leukoderma in leather manufacturing workers who wore rubber gloves cured with ...
[28]
Compounded Monobenzone for Vitiligo Depigmentation
Jul 6, 2018 · Monobenzone creams must be compounded in a proper compounding pharmacy. CareFirst Specialty Pharmacy has extensive experience in compounding ...
[29]
Mechanism of action of 4‐substituted phenols to induce vitiligo and ...
Skin contact with phenols or catechols, such as monobenzyl ether of hydroquinone (MBEH or monobenzone, in this study referred to as 4‐benzyloxyphenol, BOP), ...
[30]
Monobenzone USP: Clinical Profile and Pharmaceutical Applications
Monobenzone acts by selectively impairing melanin production in the skin. ... There is limited systemic absorption when monobenzone is applied topically ...
[31]
Position statement from the international Vitiligo Task Force—Part 2 ...
Sep 15, 2023 · Systemic absorption is a concern when large areas of skin or regions ... MBEH (p-benzyloxy-phenol, monobenzone) is the only topical ...
[32]
Optimization of Monobenzone-Induced Vitiligo Mouse Model ... - MDPI
Apr 10, 2023 · After entering melanocytes, MBEH is metabolized by tyrosinase to form superoxide ions, which then form hydrogen peroxide to promote the ...<|control11|><|separator|>
[33]
A reactive ortho-quinone generated by tyrosinase-catalyzed ...
Monobenzone (hydroquinone monobenzylether, 1) is a potent skin depigmenting agent that causes irreversible loss of epidermal melanocytes by way of a ...Missing: stability sensitivity light phenolic
[34]
MONOBENZONE - TOPICAL (Benoquin) side effects, medical uses ...
SIDE EFFECTS: Mild burning, irritation, redness, cracking, or peeling of the treated skin may occur. · PRECAUTIONS: Before using monobenzone, tell your doctor or ...Medication Uses · How To Use · Side Effects · Precautions
[35]
Benoquin Side Effects: Common, Severe, Long Term - Drugs.com
severe skin irritation; · intense itching; · severe burning; or · redness or swelling of treated skin.
[36]
Monobenzyl ether of hydroquinone 20 and 40% cream in...
The cream was regularly applied twice daily to the target area over 1 year or till complete depigmentation was achieved. Patients were instructed to avoid ...
[37]
Contact hypersensitivity to monobenzyl ether of hydroquinone used ...
Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo. Contact Dermatitis. 1998 Sep;39(3):132-3. doi: 10.1111/j.1600-0536.1998 ...
[38]
Contact hypersensitivity to monobenzyl ether of hydroquinone used ...
Feb 14, 2007 · Monobenzyl ether of hydroquinone. A retrospective study of treatment of 18 vitiligo patients and a review of the literature. Br J Dermatol 1977: ...
[39]
monobenzone | Dosing & Uses - medtigo
After absorption, monobenzone's distribution is primarily within the skin layers where it is applied. It acts locally on melanocytes, the skin cells ...
[40]
Psychosocial and quality-of-life factors associated with ...
Mar 25, 2023 · This study explores patients' perspective and experience while undergoing depigmentation therapy and quality-of-life effects of such therapy.Missing: readiness | Show results with:readiness
[41]
OCCUPATIONAL LEUKODERMA: PRELIMINARY REPORT | JAMA
Cite This. Citation. Oliver EA, Schwartz L, Warren LH. OCCUPATIONAL LEUKODERMA: PRELIMINARY REPORT. JAMA. 1939;113(10):927–928. doi:10.1001/jama.Missing: Shwartz | Show results with:Shwartz
[42]
Inhibition of Melanin Formation by Chemical Agents - ScienceDirect
8. E.A. Oliver, L. Schwartz, L.H. Warren. Occupational leukoderma. J.A.M.A., 113 (1939), p ...Missing: Shwartz | Show results with:Shwartz<|control11|><|separator|>
[43]
History of hydroquinone
The same investigators did clinical studies on hydroquinone and found it less effective than monobenzone in reducing normal or abnormal skin colour. In 1961, Dr ...Introduction · Hydroquinone In Early Years · Conclusion
[44]
A Comprehensive Review on Present and Future of ...
Studies focusing on the pharmacotherapy of vitiligo disease and various medical treatments have been collected and summarized from 1992 until 2019. Results.
[45]
Canadian Consensus Guidelines for the Management of Vitiligo - PMC
Monobenzone (monobenzyl ether of hydroquinone) [88] is approved in certain jurisdictions as a depigmentation therapy for patients with vitiligo; however, it ...Graphical Abstract · Literature Search And Expert... · Repigmentation And...
[46]
Cosmetic Ingredient Hotlist - Canada.ca
Aug 13, 2025 · List of Ingredients that are Prohibited for Use in Cosmetic Products ; 65-49-6 · 103-16-2 · 5862-77-1;; 6219-69-8; ; Monobenzone.
[47]
[PDF] Vitiligo - FDA
Mar 8, 2021 · Your doctor believes that you/your loved one may be a good candidate for this medication. The topical cream needs to be applied once a day.
[48]
Vitiligo treatments help patients get through rough patch
Jan 11, 2016 · “The only FDA-approved drug for vitiligo is monobenzone, which completely and irreversibly depigments the skin; it's only used in the minority ...
[49]
Monobenzone Compounded - CareFirst Specialty Pharmacy
Here at CareFirst Specialty Pharmacy, we have the ability to compound monobenzone in a variety of strengths for patient-specific requirements. Form. Choose an ...Missing: formulations | Show results with:formulations
[50]
Hill's Compounding Pharmacy
Hill's Compounding Pharmacy is a recognized leader in preparations for the treatment of vitiligo through the use of monobenzone creams for depigmentation.