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Pleconaril

Pleconaril is an experimental oral antiviral drug with the chemical formula C18H18F3N3O3, designed to inhibit replication of viruses in the Picornaviridae family, particularly enteroviruses and rhinoviruses, by binding to a hydrophobic pocket in the viral capsid and inducing conformational changes that disrupt receptor binding and uncoating.^[1]^[2] Developed jointly by ViroPharma and Sanofi-Synthélabo (formerly Sterling Winthrop) in the late 1990s, pleconaril demonstrated promising efficacy in early clinical trials for treating picornavirus-induced respiratory infections, such as the common cold, by significantly reducing symptom duration and severity in adults when administered early.^[3]^[4] It also showed activity against severe enteroviral conditions, including meningitis and sepsis syndrome in neonates, positioning it as a potential candidate for life-threatening infections.^[5]^[6] Despite these results, pleconaril's development was discontinued in 2002 after the U.S. Food and Drug Administration (FDA) declined approval for common cold treatment due to safety concerns, including induction of the CYP3A enzyme—which could interact with oral contraceptives—and common side effects such as headache, diarrhea, and nausea.^[1]^[7]^[8] It received orphan drug designation in 2014 for certain rare enteroviral infections but remains unapproved for any indication.^[9] As of 2025, ongoing research includes three-year follow-up data showing reduced decline in C-peptide in type 1 diabetes patients treated with pleconaril and ribavirin, and synergistic combinations with other antivirals like rupintrivir and mindeudesivir for EV-D68 and other enteroviruses.^[7]^[10]^[11]^[12]^[13]^[14]

Background

Description and properties

Pleconaril is a small-molecule antiviral agent belonging to the capsid inhibitor class, specifically designed as an orally administered drug targeting non-enveloped RNA viruses within the Picornaviridae family.^[15]^[1] Its chemical formula is C18H18F3N3O3, with a molecular weight of 381.35 g/mol.^[1]^[15] Physically, pleconaril appears as a white to off-white crystalline solid, with a melting point of 61–62°C and a density of approximately 1.271 g/cm³; it exhibits poor solubility in water (less than 0.1 mg/mL) but is soluble in organic solvents such as DMSO (up to 100 mg/mL).^[16]^[17]^[18] Due to its low aqueous solubility, pleconaril is typically formulated for oral administration as 200 mg hard gelatin capsules or as an oral solution/suspension at concentrations around 40 mg/mL.^[19]^[6]

Target pathogens

Pleconaril is primarily targeted at members of the Picornaviridae family, particularly viruses within the Enterovirus genus, such as coxsackieviruses, echoviruses, and polioviruses, as well as the Rhinovirus genus, which is the predominant cause of the common cold.^[5]^[20] These non-enveloped, positive-sense single-stranded RNA viruses lack effective antiviral therapies, making pleconaril a candidate for addressing infections ranging from mild respiratory illnesses to severe conditions like viral meningitis and myocarditis.^[21] The drug exhibits broad-spectrum activity against picornaviruses, inhibiting over 90% of the 101 known rhinovirus serotypes and more than 99% of clinical enterovirus isolates in vitro at achievable plasma concentrations of 2–3 μg/mL.^[20]^[5] Specifically, pleconaril demonstrates potent inhibition of viral replication with IC50 values typically ranging from 0.01 to 1 μg/mL (approximately 0.02–2 μM) for susceptible strains across these genera, reflecting its efficacy against representative examples like coxsackievirus A9 (IC50 0.005 μM) and echovirus 11 (MIC90 0.02 μM).^[22]^[23] Despite this specificity, pleconaril's spectrum is limited to non-enveloped picornaviruses and shows no activity against enveloped viruses or other non-picornaviral pathogens, such as influenza viruses or herpesviruses, due to its targeted capsid-binding mechanism.^[5] This narrow focus underscores its development to fill unmet medical needs in treating non-polio enteroviral diseases, which cause significant morbidity in immunocompromised patients, and rhinoviral infections, which are linked to asthma exacerbations in vulnerable populations.^[24]^[25]

Development and history

Discovery and preclinical studies

Pleconaril, known chemically as WIN 63843, emerged from a series of capsid-binding antiviral compounds developed at Sterling Winthrop Research Institute starting in the late 1970s. Initial efforts focused on identifying inhibitors of picornavirus replication, beginning with the discovery of arildone (WIN 38020) in 1979, which targeted the viral capsid and demonstrated activity against poliovirus and related enteroviruses in early in vitro screens.^[26] Through iterative chemical optimization, researchers synthesized and tested hundreds of analogs, refining structural features such as isoxazole and oxadiazole moieties to enhance binding affinity to the hydrophobic pocket in the VP1 capsid protein. This lead optimization process, spanning the 1980s, culminated in pleconaril's identification as a broad-spectrum candidate by the early 1990s, with a U.S. patent application filed on April 15, 1992, by inventors Guy D. Diana and Theodore J. Nitz, assigned to Sterling Winthrop Inc. (later transferred to Sanofi following the 1994 acquisition).^[27]^[28] Preclinical in vitro studies confirmed pleconaril's potent inhibition of rhinovirus and enterovirus replication across diverse serotypes. For instance, it exhibited submicromolar IC50 values against 214 of 215 clinical enterovirus isolates, with particularly strong activity against echovirus 11 (IC50 ≤ 0.02 μM), preventing viral uncoating by stabilizing the capsid. These assays, conducted in cell cultures such as HeLa and MRC-5, highlighted its broad-spectrum potential while showing minimal cytotoxicity at effective concentrations. Early challenges included improving oral bioavailability, as initial analogs suffered from poor absorption; structural modifications, such as incorporating a propyl linker between the phenoxy and isoxazole groups, addressed this by enhancing lipophilicity without compromising potency.^[29]^[28] In animal models, pleconaril demonstrated efficacy in reducing viral replication and disease severity. Oral administration in suckling mice infected with coxsackievirus A9 reduced mortality by up to 90% at doses of 200 mg/kg/day and lowered viral titers in tissues by 1–4 log10. Similar protective effects were observed in weanling mice with coxsackievirus A21 and adult mice with coxsackievirus B3, where treatment decreased heart and pancreas viral loads by 4–7 log10 and alleviated symptoms of enteroviral meningitis, such as paralysis and weight loss. These studies, performed in the late 1990s, supported progression to human trials after ViroPharma acquired U.S. and Canadian rights in 1995, following screening of over 200 optimized analogs.^[29]^[30]

Regulatory and approval status

Pleconaril was submitted for approval by ViroPharma as a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) in 2001 for the treatment of the common cold caused by picornaviruses.^[31] The FDA advisory panel rejected the application in 2002, citing insufficient evidence of clinical efficacy and safety concerns, particularly its induction of cytochrome P450 3A4 (CYP3A4), which could lead to significant drug interactions.^[32]^[1] Following the rejection, ViroPharma re-licensed rights to an intranasal formulation of pleconaril to Schering-Plough in 2003, with the company exercising its option in 2004 to pursue further development and commercialization in the U.S. and Canada.^[33]^[34] Schering-Plough conducted a phase II clinical trial in 2007 evaluating the intranasal form for common cold symptoms and asthma exacerbations, but the program did not advance to further regulatory submission, and oral pleconaril development was discontinued.^[35] As of 2025, pleconaril has not received full marketing approval in the United States or any other country.^[9] Despite the lack of approval, pleconaril has been accessible through the FDA's Expanded Access program (formerly known as compassionate use) for treating severe, life-threatening enteroviral infections, such as neonatal sepsis and chronic meningoencephalitis, where no other options exist.^[6] Over 300 patients have received pleconaril under this program for documented enteroviral infections by 2021, with favorable outcomes reported in many cases of immunocompromised or neonatal patients.^[36] Pleconaril retains Investigational New Drug (IND) status with the FDA, supporting ongoing research including its 2014 orphan drug designation for symptomatic enteroviral infection in neonates.^[9] It remains unavailable for commercial use but can be obtained through manufacturer-sponsored expanded access protocols for eligible severe cases.^[37]

Pharmacology

Mechanism of action

Pleconaril exerts its antiviral activity by binding to a conserved hydrophobic pocket located beneath the canyon region on the surface of the VP1 capsid protein in picornaviruses. This pocket, situated within the β-barrel domain of VP1, is typically occupied by a sphingosine-like lipid molecule known as the "pocket factor," which helps stabilize the viral capsid during maturation. Upon binding, pleconaril displaces this pocket factor and occupies the site with its benzimidazole core and extended heterocyclic rings, fitting snugly due to favorable hydrophobic interactions and hydrogen bonding with residues such as Tyr152. X-ray crystallography studies, including structures deposited in the Protein Data Bank (e.g., PDB ID: 1C8M for human rhinovirus 16 complexed with pleconaril from 1999), reveal that the drug induces minor conformational shifts in the VP1 protein, with root-mean-square deviations typically less than 0.8 Å in rhinovirus 16, thereby rigidifying the capsid structure.^[38]^[39]^[26] By filling the VP1 pocket, pleconaril stabilizes the viral capsid against conformational changes necessary for uncoating, preventing the release of the viral RNA genome into the host cell cytoplasm. This stabilization inhibits the acid-induced transition from the native A particle to the altered B or C particle forms that occurs in the acidic environment of endosomes following receptor-mediated endocytosis. Although pleconaril can alter the virus's interaction with host cell receptors by modifying the canyon region's flexibility, it does not directly block viral attachment to the cell surface or subsequent genome replication processes. Instead, its primary inhibitory effect occurs post-attachment and pre-replication, specifically by maintaining capsid integrity during the endosomal acidification step, thereby trapping the RNA within the intact virion.^[38]^[2]^[15] Structural analyses confirm that pleconaril's binding orientation— with its isoxazole ring near the pocket entrance and the trifluoromethyl-substituted phenyl ring deeper within—optimizes occupancy and enhances capsid compression, contributing to the drug's broad-spectrum activity against various picornaviruses. These insights from crystallographic data underscore how pleconaril mimics and displaces the natural pocket factor to lock the capsid in a non-infectious conformation, effectively halting the early stages of viral infection without interfering with later replication events.^[38]^[39]

Pharmacokinetics

Pleconaril exhibits rapid oral absorption, with peak plasma concentrations (Cmax) of approximately 1.1–2.4 μg/mL achieved 1.5–5 hours after single doses of 200–400 mg in adults.^[19] The absolute oral bioavailability is about 70% when administered in the fed state, and food intake significantly enhances absorption by approximately 2.2-fold compared to fasting conditions, primarily by increasing the extent rather than the rate of uptake.^[40]^[41] Following absorption, pleconaril is widely distributed throughout the body, including key tissues such as the respiratory tract, liver, nasal secretions, and central nervous system (CNS).^[41] The volume of distribution is approximately 1.9 L/kg, and the drug is highly bound to plasma proteins (>99%).^[41]^[15] It demonstrates excellent penetration into the CNS, with concentrations in brain tissue several-fold higher than in serum, although free unbound levels in cerebrospinal fluid may be lower due to extensive protein binding.^[42]^[43] Pleconaril undergoes primary hepatic metabolism, predominantly via the cytochrome P450 3A4 (CYP3A4) enzyme, producing inactive metabolites.^[15] The drug acts as an inducer of CYP3A4, leading to autoinduction upon repeated dosing that can reduce its own plasma concentrations by enhancing clearance.^[44] This induction effect persists for at least 6 days after discontinuation but resolves within 13 days.^[44] Elimination of pleconaril occurs primarily through biliary and fecal excretion, with approximately 80% of an oral dose recovered in feces within 48 hours and the remainder via urine.^[2] The apparent elimination half-life following a single dose averages 6–7 hours in fed adults, though it may shorten with chronic administration due to autoinduction.^[41] No specific dose adjustments are required for mild renal or hepatic impairment based on available data.^[15]

Clinical studies

Trials for picornaviral infections

Pleconaril underwent Phase III clinical trials in the late 1990s and early 2000s for the treatment of common colds caused by rhinoviruses, involving over 2,000 adult participants across two multicenter, double-blind, randomized, placebo-controlled studies. In these trials, patients received 400 mg of oral pleconaril three times daily for 5 days, starting within 24 hours of symptom onset. The primary endpoint was the time to complete resolution of symptoms, with secondary measures including symptom severity and viral shedding. Pleconaril reduced the median duration of illness by approximately 1 day compared to placebo (from about 7 days to 6 days; P < 0.001) and decreased symptom severity scores by 19% by day 2 (P < 0.05), though benefits were primarily observed in picornavirus-confirmed cases. Viral load in nasopharyngeal samples showed a greater median percentage reduction by day 3 in the treatment group versus placebo (97.7% vs. 90.3%; P < 0.001). However, trials for rhinovirus prevention, such as a nasal spray formulation, did not demonstrate statistically significant reductions in infection rates or symptom prevention. For enteroviral infections, pleconaril was evaluated in a Phase II/III analysis of two placebo-controlled trials focusing on meningitis in adults and children, with 240 confirmed enterovirus-positive cases out of 607 randomized patients. Dosing was 200 mg orally three times daily for 7 days. The key endpoint was time to resolution of headache, a primary symptom of meningitis. Overall, there was no significant difference in median time to headache resolution (P = 0.15), but subgroups with moderate to severe nausea or high baseline headache scores showed reductions of 1 to 2.5 days (e.g., 7 days vs. 9.5 days for nausea subgroup; P = 0.009). A separate double-blind trial in infants ≤12 months with suspected enteroviral meningitis (n=21 evaluable, 20 confirmed) used 5 mg/kg orally three times daily for 7 days but found no significant differences in symptom duration, hospitalization length, or viral clearance from cerebrospinal fluid via culture or PCR. In neonates with enterovirus sepsis, a randomized, double-blind, placebo-controlled trial (n=61; 43 pleconaril, 18 placebo) administered 5-8.5 mg/kg orally every 8 hours for 7 days. The primary endpoint of oropharyngeal culture positivity on day 5 was negative in both groups (0%), but pleconaril showed a non-significant trend toward faster time to culture negativity (median 4 vs. 7 days; P = 0.08) and reduced PCR positivity at final sampling (23% vs. 58%; P = 0.02), with a non-significant trend toward lower mortality (23% vs. 44% in intent-to-treat; P = 0.02 overall but P = 0.26 for confirmed cases). Compassionate use data from a registry of 38 patients with potentially life-threatening enteroviral infections, including neonatal sepsis cases, reported an 80% clinical response rate, with virological clearance in 92% of assessed cases and improved survival in severe presentations like hepatitis and myocarditis. Outcomes indicated marginal efficacy for mild picornaviral infections such as common colds but more promising results for severe enteroviral cases, including chronic meningoencephalitis in immunocompromised patients, where symptom resolution and viral suppression were observed in up to 75% of treated individuals. These trial results contributed to regulatory challenges, as the modest benefits for common colds did not meet approval thresholds despite antiviral activity.

Trials for other indications

Pleconaril has been investigated in phase II clinical trials during the 2000s for its potential to mitigate asthma exacerbations associated with rhinovirus infections, a common picornavirus trigger. In a randomized, double-blind, placebo-controlled study involving asthmatic participants exposed to rhinovirus (NCT00394914), intranasal pleconaril was evaluated for reducing exacerbation frequency during the cold season. In a phase II trial (n=311) of intranasal pleconaril in asthmatic participants with rhinovirus exposure, there was no significant reduction in exacerbation frequency (p=0.425) compared to placebo, but the trial and broader development program were halted due to regulatory and safety concerns related to the compound's overall profile.^[45]^[46] More recently, a phase II randomized trial (DiViD intervention study) assessed pleconaril in combination with ribavirin for new-onset type 1 diabetes (T1D) in children and adolescents, hypothesizing an enteroviral role in disease etiology. Conducted in 96 participants aged 6-15 years, the 26-week treatment preserved stimulated C-peptide levels—a key marker of beta-cell function—at 12 months (mean 0.55 pmol/mL in the treatment group vs. 0.39 pmol/mL in placebo; adjusted mean difference 0.057, 95% CI 0.004-0.11, P=0.037), with a relative decline of 11% versus 24% in the placebo group. These findings, published in Nature Medicine, suggest antiviral therapy may slow beta-cell loss in early T1D.^[47] A three-year follow-up of the DiViD study showed no significant difference in C-peptide levels at 3 years (treatment 0.25 vs. placebo 0.17 pmol/ml; P=0.12), indicating the initial benefits were not sustained long-term.^[12] Exploratory small-scale studies in the 2010s have examined pleconaril for polio-like acute flaccid myelitis (AFM), a severe enteroviral condition, though evidence remains limited to preclinical analogs and case observations rather than dedicated trials. Anecdotal benefits have also been noted in immunodeficient patients with persistent enteroviral shedding, such as those with severe combined immunodeficiency or X-linked agammaglobulinemia experiencing chronic meningoencephalitis; compassionate use of pleconaril led to viral clearance and clinical improvement in isolated cases without large randomized controlled trials.^[48]^[49]^[50] As of 2025, investigational new drug applications support ongoing trials of pleconaril for T1D preservation and severe enteroviral diseases. No phase III trials have advanced for non-picornaviral indications due to challenges in establishing broader efficacy.^[47]

Resistance and limitations

Viral resistance mechanisms

Pleconaril inhibits picornaviruses by binding to a hydrophobic pocket in the VP1 capsid protein, and viral resistance primarily arises from point mutations in the VP1 gene that alter this pocket, thereby reducing the drug's binding affinity.^[23] In human rhinoviruses, naturally resistant strains often feature substitutions at VP1 residues 152 (tyrosine to phenylalanine) and 191 (valine to leucine), which sterically hinder pleconaril integration into the pocket; experimental substitution of valine 191 to leucine in susceptible HRV-14 reduces susceptibility, while the double mutation confers full resistance.^[51] Acquired resistance involves similar pocket alterations, with clinical isolates showing mutations at various VP1 sites such as 98, 124, 142, and 191, leading to decreased drug efficacy.^[52] In vitro studies using engineered mutants of rhinoviruses demonstrate resistant variants with 10- to 40-fold higher IC50 values compared to wild-type strains, often due to single amino acid changes like alanine 150 to valine in HRV-14.^[53] These resistant strains exhibit cross-resistance to other capsid inhibitors, such as pirodavir and vapendavir, as the mutations similarly disrupt shared binding interactions within the VP1 pocket.^[53] Resistance emergence frequency in such selections is approximately 5 × 10-5, indicating a moderate barrier to mutation under drug pressure.^[54] Clinically, resistance develops in 10-20% of treated patients, with 10.7% showing ≥10-fold reduced susceptibility and 2.7% fully resistant isolates (IC50 >3.8 μg/ml) after pleconaril exposure in common cold trials.^[23] In chronic infections among immunodeficient patients, such as those with agammaglobulinemia harboring persistent parechovirus, pleconaril fails to suppress viral replication, suggesting pre-existing or rapidly emerging resistance.^[55] Resistant variants typically display reduced viral fitness, evidenced by lower titers and shorter illness duration, with no observed community transmission.^[23] This limits pleconaril's utility for prolonged therapy, prompting proposals for combination regimens with agents like rupintrivir to delay resistance onset. Recent in vitro studies have shown that combining pleconaril with rupintrivir and remdesivir delays resistance development in enteroviruses, though these remain untested clinically.^[14]

Clinical and pharmacological limitations

Pleconaril demonstrates variable efficacy across picornavirus serotypes, with in vitro studies showing potent inhibition of most enterovirus clinical isolates but reduced activity against certain strains such as coxsackievirus B3 (CVB3), where the MIC90 reaches 0.37 μM compared to 0.02 μM for echovirus 11 (EV11).^[5] In clinical trials for common colds caused by picornaviruses, pleconaril reduced symptom duration by approximately one day and eased severity, but these benefits were modest and inconsistent across all infections.^[56] Furthermore, its therapeutic window is narrow, requiring administration within 24 hours of symptom onset to achieve meaningful reductions in illness duration and viral shedding, which limits practical application in routine settings where early diagnosis is challenging.^[56] A significant pharmacological limitation is pleconaril's induction of cytochrome P450 3A4 (CYP3A4) enzyme activity, which accelerates its own metabolism and that of other substrates like ethinyl estradiol upon repeated dosing, potentially leading to subtherapeutic drug levels after prolonged treatment.^[24] This auto-induction contributed to concerns over drug interactions and inconsistent pharmacokinetics, playing a central role in the FDA's 2002 rejection of pleconaril for approval.^[57] Practical barriers further restrict pleconaril's use, including the lack of rapid, widely available diagnostic tests for picornavirus identification, which complicates timely initiation in non-severe cases where symptoms overlap with other respiratory illnesses.^[58] Although available through compassionate use programs for over 300 patients with severe enteroviral infections, its unapproved status confines it to niche applications in life-threatening scenarios rather than routine prophylaxis or broad treatment.^[36] These combined limitations—modest and serotype-dependent efficacy, narrow treatment timing, metabolic auto-induction, and diagnostic hurdles—have prevented pleconaril from achieving widespread clinical adoption beyond investigational contexts.^[56]

Safety profile

Adverse effects

Pleconaril was generally well tolerated in large-scale clinical trials, with the majority of adverse effects classified as mild or moderate in severity.^[4] The most frequently reported adverse effects included headache, nausea, and diarrhea. Headache occurred more commonly in the pleconaril group than in placebo recipients, though incidences were low and symptoms were typically self-resolving within days. Nausea was observed in 6% of pleconaril-treated patients compared to 4% in the placebo group, while diarrhea affected 9% versus 7%, respectively; these gastrointestinal effects were also generally mild and transient.^[4] Serious adverse effects were uncommon, with an incidence of less than 1% across two double-blind, placebo-controlled trials involving over 2,000 participants (1,046 receiving pleconaril and 1,050 receiving placebo). Four serious events occurred in the pleconaril arm compared to two in placebo, but none were deemed drug-related except for one instance of overdose that resolved without long-term consequences; no fatalities were attributed to pleconaril treatment.^[4] Additional laboratory findings included modest elevations in mean serum cholesterol (by approximately 5 mg/dL in 3% of patients) and platelet counts (by 15 × 10³/mm³ in 6% of patients) among those receiving pleconaril, though these changes were not associated with clinical symptoms. Management of common adverse effects typically involved supportive care for gastrointestinal symptoms, with dose reduction or discontinuation reserved for persistent or severe cases.^[4]

Drug interactions

Pleconaril induces the activity of cytochrome P450 3A4 (CYP3A4), accelerating the metabolism of CYP3A4 substrates and leading to clinically significant pharmacokinetic interactions.^[15] This induction is particularly concerning with oral contraceptives, as pleconaril reduces the area under the curve of plasma ethinyl estradiol levels by approximately 34% after single-dose administration, thereby decreasing contraceptive efficacy and elevating the risk of unintended pregnancy.^[4] Similar effects may occur with other CYP3A4 substrates, such as the antihistamine terfenadine, potentially altering its exposure, though terfenadine is now rarely used due to its independent association with QT prolongation.^[37] No significant pharmacokinetic interactions have been reported with antiretrovirals or common antibiotics, based on available clinical data.^[15] Due to these interactions, pleconaril is contraindicated with hormonal contraceptives, and alternative non-estrogen-based birth control methods are recommended during and shortly after treatment to mitigate pregnancy risks.^[19] These findings stem from dedicated drug interaction studies conducted in the 1990s and early 2000s, which highlighted CYP3A4-related risks as a key factor in the drug's regulatory challenges.^[4]

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Enteroviral Meningitis: Natural History and Outcome of Pleconaril ...
Pleconaril attains severalfold-higher concentrations within the central nervous system than in serum, a feature that is beneficial for patients with ...
[39]
Results from a Phase IIa Trial Evaluating Apovir, an Antiviral Drug ...
May 16, 2021 · Additionally, more than 300 subjects have been treated with pleconaril in a compassionate use program designed to treat patients with severe ...Missing: expanded | Show results with:expanded<|control11|><|separator|>
[40]
Duration of pleconaril effect on cytochrome P450 3A activity in ...
The duration of increased CYP3A activity by pleconaril was at least 6 days (but no longer than 13 days) after pleconaril discontinuation.Missing: feces urine
[41]
Effects of Pleconaril Nasal Spray on Common Cold Symptoms and ...
Jul 16, 2015 · A Placebo-Controlled Study of the Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus ...Missing: unmet enterovirus
[42]
Opportunities for rhinovirus-targeted RNA therapeutics: A narrative ...
The trial failed to meet its primary endpoint of a statistically significant reduction in symptoms as assessed by the asthma control questionnaire-6. [23]. II ...
[43]
Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 ...
Oct 4, 2023 · The results show that antiviral treatment may preserve residual insulin production in children and adolescent with new-onset T1D.<|control11|><|separator|>
[44]
Efficacy of an isoxazole-3-carboxamide analog of pleconaril in ...
Accumulating evidence also supports an association between EV-D68 and acute flaccid myelitis (AFM) (Messacar et al., 2018), a disease which afflicts ...
[45]
Successful treatment of enterovirus infection with the use ... - PubMed
Two patients with severe combined immunodeficiency and enterovirus infections were successfully treated with pleconaril. There were no adverse affects.Missing: chronic | Show results with:chronic
[46]
Pleconaril Revisited: Clinical Course of Chronic Enteroviral ...
Since pleconaril is no longer available for compassionate use we strongly propagate that new drugs should be developed against these potential life threatening ...
[47]
Three-Year Follow-up After Antiviral Treatment in New-Onset Type 1 ...
Jan 13, 2025 · Pleconaril reduces neonatal death resulting from severe enteroviral sepsis (20). Ribavirin is a nucleoside analog with broad-spectrum antiviral ...
[48]
Insights into the genetic basis for natural phenotypic resistance of ...
A consistent difference was observed at two positions: the vast majority of susceptible viruses had tyrosine and valine at VP1 residues 152 and 191, ...Missing: mutations | Show results with:mutations
[49]
VP1 Sequencing of All Human Rhinovirus Serotypes: Insights into ...
Furthermore, all residues within 5 Å of any mutated amino acid of either the empty or the pleconaril-occupied pocket of wild-type and variant viruses were ...
[50]
In vitro characterisation of a pleconaril/pirodavir-like compound with ...
Jul 14, 2015 · The molecule ca603 shows antiviral activity against a panel of rhino-and enteroviruses. Cross-resistance is observed against viruses with ...Missing: formula weight
[51]
Molecular mechanism of a specific capsid binder resistance caused ...
Single-site mutations cause high-resistance (HR) to capsid-binding inhibitors. · Two new HR amino acid substitutions were identified in viral capsid protein 1.Abstract · Introduction · References (42)<|control11|><|separator|>
[52]
Pleconaril-resistant chronic parechovirus-associated enteropathy in ...
The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related ...
[53]
The combination of pleconaril, rupintrivir, and remdesivir efficiently ...
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant ...Missing: IC50 | Show results with:IC50
[54]
FDA panel refuses anti-viral cold remedy - Medindia
One concern is that pleconaril tablets must be taken within 24 hours of the first symptoms, making the drug's real-life usefulness questionable. Because colds ...Missing: rejection limitations
[55]
Novel pleconaril derivatives: Influence of substituents in the ...
Feb 15, 2020 · A series of novel pleconaril derivatives with substitutions in the isoxazole and phenyl rings was synthesized and evaluated for their antiviral activity.Missing: IC50 | Show results with:IC50<|control11|><|separator|>
[56]
[PDF] Dissecting Pandemic-Prone Viral Families, Volume 1
Dec 1, 2023 · ... lack.of.diagnostic.tests.has.obscured. the.role.of.rhinoviruses.in ... pleconaril,.failed.to.garner. FDA.approval.due.to.side.effects ...
[57]
Drug Interactions | SpringerLink
Pleconaril is a CYP3A inducer, and its administration may decrease plasma concentrations of CYP3A substrates, including some contraceptive steroids (2). We ...
[58]
Safety and Efficacy Evaluation of Pleconaril for Treatment of the ...
Pleconaril rapidly induces production of CYP3A4, which likely led to the inter- menstrual bleeding and other menstrual abnormalities seen in women taking ple-.