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Remilk

Remilk is an Israeli biotechnology company founded in 2019 that develops animal-free dairy products using precision fermentation to produce milk proteins identical to those from cows, without involving animals or traditional farming.^[1]^[2] The company, headquartered in Ness Ziona, Israel,^[3] was established by CEO Aviv Wolff, an entrepreneur with experience in business and social initiatives, and CTO Ori Cohavi, who holds a PhD in biochemistry and biology.^[4]^[2] Remilk's mission is to reimagine dairy production as a sustainable, cruelty-free alternative that benefits the planet, animals, and human health by providing lactose-free options free of cholesterol, hormones, and antibiotics while maintaining the taste, texture, and protein nutritional profile of conventional dairy.^[5]^[1] The core technology at Remilk involves inserting the gene for cow's milk proteins into yeast cells, which are then fermented in large-scale bioreactors to generate the proteins at a molecular level, combined with non-animal fats, sugars, vitamins, and minerals to form complete dairy products.^[1] This process, known as microbial precision fermentation, allows for scalable production that is resource-efficient, using up to 99% less land and more than 90% less water than traditional dairy farming, and produces zero methane emissions.^[6] Double-blind taste tests have confirmed that Remilk's proteins are indistinguishable from animal-derived ones in flavor and functionality, enabling applications in milk, cheese, yogurt, and ice cream.^[1] The company's innovations address the dairy industry's environmental footprint, which contributes significantly to global greenhouse gas emissions, while providing healthier options for lactose-intolerant consumers and those seeking ethical alternatives.^[5]^[1] Since its inception, Remilk has achieved several regulatory and commercial milestones, including a Series A funding round of $11 million in December 2020 and total funding exceeding $150 million as of November 2025 to support scaling operations.^[7]^[8]^[9] In April 2023, it became the first company to receive regulatory approval for non-animal milk protein in Israel, preceded by self-affirmed GRAS status in the US in June 2022 and approval in Singapore, followed by clearance in Canada in February 2024.^[7]^[10]^[11] In April 2022, Remilk announced plans to build the world's largest precision fermentation facility in Denmark to ramp up production.^[2] Most recently, in November 2025, the company partnered with Israeli dairy producer Gad Dairies to launch "The New Milk," the first cow-free milk product available in cafés, restaurants, and major retailers across Israel, marking a significant step toward mainstream adoption of recombinant dairy.^[8]^[9]

History

Founding

Remilk was founded in 2019 in Rehovot, Israel, as a food-tech startup specializing in animal-free dairy products using precision fermentation.^[12]^[13]^[14] The company was established by CEO Aviv Wolff and CTO Ori Cohavi. Aviv Wolff, an entrepreneur with prior experience in startups including as COO at CyberTraits, brought business and social initiative expertise to the venture.^[15]^[16] Ori Cohavi, holding a PhD in biochemistry from the Weizmann Institute of Science and previous role as Head of Discovery at Mitoconix Bio, contributed synthetic biology knowledge.^[17]^[18] The initial mission centered on producing real dairy proteins without animals through microbial technology, specifically precision fermentation, to tackle sustainability challenges in the dairy industry, including high resource consumption and environmental impact.^[5]^[19] Remilk's early vision aimed to reshape dairy production by eliminating dependency on cows while preserving the taste, nutrition, and functionality of traditional dairy products.^[20]^[5]

Early Development and Milestones

Remilk's early development phase from 2020 to 2021 focused on key R&D breakthroughs in lab-scale production of animal-free milk proteins using precision fermentation. In December 2020, the company secured $11.3 million in Series A funding to advance these efforts and transition from laboratory experiments to initial scaling of microbial processes for dairy proteins.^[21]^[22] The company's founders, Aviv Wolff and Ori Cohavi, were instrumental in guiding these initial R&D advancements, drawing on their entrepreneurial experience to establish foundational protein synthesis capabilities. In 2022, Remilk marked significant progress when it filed a GRAS notice with the FDA for its core protein, beta-lactoglobulin (GRN 001056), in June, receiving a letter of no objection in February 2023, enabling commercial sales of animal-free dairy ingredients in the United States.^[23]^[24] This regulatory achievement coincided with substantial team expansion, supported by a $120 million Series B funding round in January, which facilitated pilot testing of production processes and preparations for broader market entry and brought total funding to approximately $131 million.^[25] By 2023, Remilk introduced its first commercial prototypes amid growing partnerships aimed at production scaling. In April, the company obtained pioneering regulatory approval in Israel for its animal-free proteins, becoming the first to achieve this for precision-fermented dairy alternatives in the country. Collaborations, including a January agreement with General Mills to integrate the technology into food applications, further propelled prototype development and testing.^[26]^[27] From 2024 to 2025, Remilk continued its regulatory momentum and commercial push. In February 2024, Health Canada issued a "Letter of No Objection" for the company's animal-free milk protein, affirming its safety and paving the way for North American market expansion. The period also saw strategic adjustments, including a pivot from initial plans for a large-scale facility in Denmark—announced in 2022 but paused amid market shifts—to partnerships with co-manufacturers for efficient scaling. In November 2025, Remilk announced a history-making milestone: the launch of the world's first commercial animal-free milk products under "The New Milk" brand, developed in collaboration with Gad Dairies and introduced in Israeli cafes and stores as lactose-free, real dairy alternatives.^[28]^[29]^[30]^[8]

Technology

Precision Fermentation Process

Remilk employs precision fermentation, a biotechnological method that utilizes genetically engineered microorganisms to produce animal-free dairy proteins. This process involves inserting specific genes into yeast cells, which then secrete proteins identical to those found in cow's milk, such as caseins and whey, enabling the creation of dairy products without animal involvement.^[1] The workflow begins with the identification and copying of genes from cows that code for key milk proteins. These genetic sequences are then inserted into yeast cells, typically from the brewer's or baker's yeast family, using recombinant DNA technology to engineer the microbes as mini-factories. Once modified, the yeast is introduced into nutrient-rich media within controlled fermenters, where it multiplies rapidly under optimized conditions of temperature, pH, and oxygen levels, expressing and secreting the target proteins into the surrounding broth.^[1]^[31] Following fermentation, the proteins are harvested through separation techniques, such as centrifugation, to isolate the microbial culture from the liquid. The secreted proteins undergo purification via filtration and chromatography to remove impurities, yeasts, and media components, yielding highly pure dairy proteins suitable for food applications. This extraction and purification stage ensures the final product meets regulatory standards for safety and purity.^[1] Scaling precision fermentation from laboratory bioreactors to industrial production presents significant challenges, including maintaining microbial productivity and genetic stability at larger volumes, as well as optimizing yields to achieve cost-competitiveness. Remilk addresses these by leveraging existing global fermentation infrastructure adapted for food-grade processes and investing in advanced bioreactor designs that support high-density cultures, enabling output equivalent to milk from thousands of cows in a single facility. In 2022, the company announced plans for a production site that would scale to the volume of 50,000 cows annually, though these plans were paused in 2023 in favor of ramping up at an existing facility in Western Europe.^[31]^[32]^[30] In contrast to traditional dairy production, which relies on the biological lactation process in cows to synthesize and assemble proteins like casein micelles and whey in milk, Remilk's method directly engineers microbes to replicate these proteins extracellularly without involving animals, hormones, or antibiotics. This microbial approach avoids the inefficiencies of animal farming, such as variable yields and resource-intensive rearing, while producing chemically identical proteins that form the same functional structures for dairy applications.^[1]^[31]

Protein Engineering

Remilk's protein engineering efforts center on replicating the core dairy proteins found in cow's milk—caseins and whey proteins—using recombinant DNA technology to enable animal-free production. The company engineers microbes, primarily yeast from the brewer's or baker's family, by inserting genetic sequences copied from cow milk genes, allowing these organisms to produce proteins identical in structure and function to their animal-derived counterparts.^[1] This approach targets key caseins, including alpha-, beta-, and kappa-caseins, which form the micellar structures essential for milk's texture and stability, as well as whey proteins such as beta-lactoglobulin and alpha-lactalbumin.^[33]^[34] The engineering process involves precise gene insertion to ensure the microbial hosts express proteins that match native dairy folds and functionalities, such as emulsification and gelation properties critical for dairy applications. These recombinant proteins are designed to assemble into casein micelles when combined with appropriate minerals, mimicking the natural organization in milk for enhanced stability during processing.^[33] Innovations include modifications that reduce potential allergens by producing high-purity proteins free from contaminants like lactose or cholesterol, while preserving nutritional profiles and sensory attributes like taste and creaminess.^[1]^[34] These engineered proteins can also be optimized for improved nutritional value, such as balanced amino acid compositions, without compromising functionality.^[33] In November 2025, Remilk's precision-fermented whey proteins were used in the launch of "The New Milk," a cow-free dairy product developed with Gad Dairies and available in Israel.^[8] Remilk holds proprietary intellectual property, including patented methods for synthesizing these animal-free proteins through engineered microbial strains that efficiently produce dairy components. This IP encompasses novel techniques for gene integration and protein expression in non-agricultural feedstocks, ensuring scalability and cost-effectiveness in precision fermentation. These proprietary strains represent a key innovation in molecular biology for sustainable dairy alternatives.^[35]^[36]

Products

Core Dairy Proteins

Remilk's core dairy proteins consist of animal-free casein and whey proteins, produced through precision fermentation and supplied primarily as powders or liquids to business-to-business (B2B) customers for use in dairy formulations.^[1] These proteins replicate the structure and functionality of their bovine counterparts, enabling the creation of dairy products that mimic traditional milk in taste, texture, and nutritional value without involving animals.^[37] The primary whey protein developed by Remilk is recombinant beta-lactoglobulin (r-βLG), which constitutes a significant portion of natural whey and is purified from fermentation media.^[38] In terms of composition, Remilk's proteins exhibit nutritional profiles closely matching those of conventional dairy, with high protein content and a complete amino acid profile essential for muscle repair and overall nutrition.^[1] Unlike traditional dairy, these proteins are inherently free of lactose and cholesterol, as they are isolated milk proteins without the accompanying carbohydrates or lipids from cow's milk, though they maintain the same bioavailability and digestibility.^[39] For instance, r-βLG provides essential branched-chain amino acids like leucine, supporting similar health benefits as bovine whey in applications requiring protein supplementation.^[38] Quality standards for Remilk's proteins emphasize high purity levels, achieved through controlled microbial fermentation and downstream purification processes that remove impurities, resulting in products exceeding 95% protein purity in dry form.^[1] The spray-dried powders offer extended shelf life comparable to commercial whey protein isolates.^[38] Certifications include self-affirmed Generally Recognized as Safe (GRAS) status from the U.S. Food and Drug Administration, confirming safety for use in food and beverages, as well as non-GMO verification due to the yeast-based production method.^[10] Additional approvals from Health Canada and other regulatory bodies further validate their purity and equivalence to animal-derived proteins.^[40] Remilk's product launch featuring these core proteins, "The New Milk," a lactose-free fluid milk alternative, launched in November 2025 for cafés and restaurants in Israel, with retail availability planned for January 2026. This launch highlights the proteins' role as a versatile base, with r-βLG contributing to the creamy texture and nutritional integrity of the final beverage.^[9]

Commercial Applications

Remilk's precision-fermented dairy proteins are formulated into a range of end-user products, including milk, ice cream, yogurt, and cheese, maintaining the texture and flavor profiles of traditional cow's milk dairy. These proteins enable the creation of animal-free alternatives that replicate the functional properties of conventional dairy, such as creaminess in ice cream and coagulation in cheese production. For instance, partnerships with manufacturers aim to develop dairy drinks, yogurts, and cheeses using Remilk's proteins as key ingredients.^[1]^[39] The company's product pipeline includes expanded animal-free dairy lines, such as low-fat milk variants and fortified options enriched with calcium and vitamins. In collaboration with Gad Dairies, Remilk launched "The New Milk" in Israel in November 2025, featuring variants including Barista Milk for food service (available in cafés and restaurants), Everyday Milk (3% fat), and a vanilla-flavored variant for retail (planned for January 2026). These products are lactose-free, cholesterol-free, fortified with calcium and vitamins, and contain 75% less sugar than standard milk. These products demonstrate Remilk's focus on customizable formulations for diverse consumer needs, including reduced-sugar and nutrient-enhanced profiles.^[35]^[34]^[39] Remilk operates primarily on a B2B model, supplying its proteins to food manufacturers for integration into hybrid or fully alternative dairy goods. This approach allows partners like CBC Group to produce mass-market lines of non-animal dairy products, such as cheeses and yogurts, tailored for regional markets. By providing scalable protein solutions, Remilk supports manufacturers in meeting demand for dairy equivalents without animal sourcing.^[41]^[42] Sensory evaluations, including double-blind taste tests, have confirmed the equivalence of Remilk-based products to cow's milk in terms of flavor, texture, and overall appeal. These tests, conducted on formulated dairy items, showed that consumers could not distinguish between Remilk versions and traditional dairy, underscoring the proteins' suitability for seamless commercial integration. Remilk's core dairy proteins thus act as versatile building blocks for these applications.^[1]

Business and Operations

Funding and Investments

Remilk has raised approximately $151 million in total funding across multiple rounds by November 2025.^[43]^[44] The company's first major funding came in December 2020 with an oversubscribed Series A round of $11.3 million, led by Israeli venture fund fresh.fund and including participants such as OurCrowd, CPT Capital, ProVeg International, and corporate investors like Hochland SE, Tnuva, and Tempo Beverages.^[45]^[46] This was followed in January 2022 by a $120 million Series B round led by New York-based Hanaco Ventures, with additional backing from Precision Capital, Rage Capital, CPT Capital, Intercap, OurCrowd, and Aliya Capital Partners, among others; the round established a post-money valuation of $325 million.^[47]^[48] In 2024, Remilk secured a $20 million later-stage investment from Tau Capital, an Abu Dhabi-based firm supported by Sheikh Tahnoon bin Zayed Al Nahyan, marking a notable UAE commitment to an Israeli startup amid regional tensions.^[43] To manage its finances effectively from inception, Remilk implemented procurement and spend management software such as Precoro, achieving full budget control and supporting scalable operations in the biotech space without initial structured processes.^[49] The raised capital has been directed toward key R&D milestones, including technology development and regulatory progress.^[50]

Facilities and Partnerships

Remilk is headquartered in Rehovot, Israel, where its primary research and development activities are conducted, supporting the company's precision fermentation innovations.^[51]^[52] The company has announced plans to construct the world's largest precision fermentation facility for animal-free dairy production in Kalundborg, Denmark, as part of the Symbiosis industrial ecosystem, a collaborative project involving local utilities and authorities to enable sustainable, resource-sharing operations.^[2]^[53] Originally targeted for scaling production equivalent to 50,000 cows annually, the project was paused in 2023 to focus on immediate capacity expansion through co-manufacturing partnerships; as of November 2025, Remilk has pivoted to utilizing existing facilities in North America, Europe, and Asia rather than proceeding with the Denmark build-out in the near term.^[54]^[55]^[43]^[9] Key partnerships include collaborations with Danish entities through the Symbiosis initiative, facilitating co-production and integration into eco-industrial networks with authorities and utilities like Kalundborg Municipality.^[56]^[57] Remilk has also formed alliances with major food companies for supply chain integration, such as a 2025 co-production agreement with Gad Dairies in Israel to manufacture and distribute animal-free milk products, and earlier deals with CBC Group for developing dairy lines using Remilk's proteins, as well as General Mills' G-Works for incorporating whey protein into innovation pipelines.^[58]^[59]^[41] As of November 2025, Remilk is in talks with partners in Saudi Arabia and Bahrain for additional investments and potential manufacturing sites.^[43] Remilk's global operations extend beyond Israel through regulatory engagements, including a "no questions" letter from the U.S. FDA in 2023 confirming the safety of its animal-free whey protein for use in food products, alongside approvals from Health Canada, Singapore's SFA, and Israel's Ministry of Health, enabling multi-national distribution and partnerships.^[60]^[61]^[58]

Impact and Sustainability

Environmental Benefits

Remilk's precision fermentation process significantly reduces the environmental footprint of dairy protein production compared to traditional cow-based methods. The company estimates that its approach uses just 1% of the land required for conventional dairy farming, representing a 99% reduction, while consuming over 90% less water.^[25]^[62] Lifecycle assessments based on Remilk's production estimates indicate a substantial decrease in carbon emissions, with the process generating only 4% of the greenhouse gas emissions associated with traditional dairy, equating to a 96% reduction overall. This lower carbon footprint arises primarily from avoiding resource-intensive farming practices and eliminating methane emissions from livestock digestion, which account for a significant portion of dairy's environmental impact.^[25] By eliminating the need for cows, Remilk's method addresses animal welfare concerns inherent in industrial dairy operations and further mitigates environmental harm through the prevention of methane and other emissions from animal agriculture. This shift supports broader sustainability objectives, including alignment with the United Nations' goal of net-zero emissions by 2050.^[63] Through its Remilk Cares program, the company advances planetary health initiatives by promoting resource-efficient food production and contributing to global efforts for food security and environmental preservation.^[63]

Market and Ethical Implications

Remilk operates within the burgeoning alternative dairy sector, positioning itself as a pioneer in precision-fermented, animal-free dairy proteins that mimic traditional dairy in taste and functionality while competing directly with plant-based alternatives like soy, almond, and oat milks.^[9] Unlike plant-based options, which dominated a market valued at USD 20.84 billion in 2024 and projected to reach USD 32.35 billion by 2030 at a CAGR of 7.4%, Remilk's products aim to capture consumers seeking "real dairy" without animal involvement, leveraging approvals in markets like the US, Israel, Singapore, and Canada to expand commercially.^[64]^[40] The overall precision fermentation market, a key area for Remilk's dairy proteins, was valued at approximately USD 5.82 billion in 2025 and is forecasted to grow to USD 151.01 billion by 2034 at a CAGR of 43.6%, driven by technological advancements and demand for sustainable proteins.^[65] Consumer trends reflect a growing preference for animal-free dairy options, fueled by health benefits such as lactose-free formulations that address intolerance affecting up to 68% of the global population, and ethical motivations including reduced animal exploitation.^[66] Surveys indicate positive attitudes among adolescents and adults toward milk alternatives, with motivations centered on perceived health improvements, environmental sustainability, and animal welfare, as animal-free products are often viewed as cleaner and more ethical than traditional dairy.^[67] Remilk's lactose-free "New Milk," launched in partnership with Gad Dairies in 2025, exemplifies this shift by offering a low-sugar, cholesterol-free alternative that appeals to health-conscious consumers without the digestive issues of conventional milk.^[9] Despite these opportunities, Remilk faces significant challenges in scaling its operations, including high production costs that hinder cost-competitiveness with traditional dairy, as well as regulatory hurdles in regions requiring extensive safety validations for biotech-derived foods. Additionally, in October 2024, four board members resigned amid leadership disputes, highlighting internal governance challenges that could affect scaling efforts.^[68]^[69] Public perception remains a barrier, with consumer skepticism toward genetically engineered or "lab-grown" products often stemming from concerns over unnaturalness and long-term safety, even as Remilk emphasizes clean-label appeal through terms like "fermentation-made" and "animal-free."^[70]^[71] Ethically, Remilk promotes its mission as delivering "joy for our planet, our body, and cows" by eliminating animal agriculture's harms, such as welfare issues in intensive farming, while producing dairy proteins without hormones or antibiotics.^[66] However, this innovation raises implications for dairy farmers' livelihoods, as precision fermentation could disrupt traditional supply chains and render conventional farming obsolete in some markets, prompting calls for transitional support and diversification opportunities for affected rural communities.^[72]^[73]

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Apr 26, 2022 · Concerning regulatory approval for commercialisation, the company said it is taking a global approach. Having its own production facility in ...<|control11|><|separator|>
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[55]
Remilk & Gad Dairies Roll Out Cow-Free Milk with Fermented Whey ...
Remilk has partnered with Gad Dairies to launch three animal-free milk products using its precision-fermented whey protein in Israel.
[56]
remilk gains regulatory approval in Singapore, US FDA
Remilk receives regulatory approval from SFA, enabling sales of its animal-free protein in Singapore, and "no questions letter" from FDA.Missing: commercial prototypes
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REMILK RACKING UP REGULATORY APPROVALS - PR Newswire
Feb 23, 2023 · In 2022, the company declared its Self-Affirmed GRAS status in compliance with the FDA's requirements, allowing it to begin sales of its protein ...<|separator|>
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How we plan to spread the love / Remilk Cares
We believe that doing good is contagious. Our Ethics, Social Responsibility, and Sustainability Program stems from our belief that if we strive for change, ...
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Plant-based Milk Market Size, Share & Growth Report, 2030
The global plant-based milk market size was estimated at USD 20.84 billion in 2024 and is projected to reach USD 32.35 billion by 2030, growing at a CAGR of 7.4 ...
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Precision Fermentation Market Size to Climb USD 5.82 Bn in 2025
Aug 1, 2025 · The precision fermentation market size expanding from USD 5.82 billion in 2025 to an estimated USD 151.01 billion by 2034 at a CAGR of 43.6% ...Missing: position | Show results with:position
[62]
Remilk: Real Dairy. No Cows.
We reimagine the future of food by crafting real dairy without a single cow, bringing a message of hope and joy to our planet, our body and cows!Newsroom · Science · Remilk Cares · Contact Remilk
[63]
Attitudes toward milk alternatives and motives for (non-)consumption
May 26, 2025 · Adolescents generally have positive attitudes toward milk alternatives, motivated by perceived health, environmental, and animal welfare benefits.Missing: Remilk | Show results with:Remilk
[64]
[PDF] 2023 State of the Industry Report - Fermentation
Yet the year was not without its challenges. Funding constraints and difficulties with scaling posed two of the biggest bottlenecks for fermentation.
[65]
Advancing synthetic biology in the dairy industry - ScienceDirect
Oct 30, 2025 · However, significant hurdles remain. Regulatory complexities and consumer skepticism about the safety and acceptance of synthetic biology ...
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https://www.remilk.com/
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Should Dairy Farmers Fear Fermentation? An In-depth Analysis of ...
May 6, 2024 · Fermentation presents challenges for dairy farmers, potentially making traditional farming obsolete, but also offers opportunities for ...
[68]
Is precision fermentation a farmers' thing? - NomadIT
Jul 16, 2024 · Precision fermentation challenges dairy farmers' livelihoods, but they are open to innovation, while feeling vulnerable and insecure about long ...