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Taste

Taste, also known as gustation, is one of the five traditional human senses that enables the detection and perception of specific chemical compounds in ingested substances, primarily through specialized sensory receptors in the oral cavity.^[1] This sense plays a crucial role in evaluating the nutritional value, safety, and palatability of food by distinguishing five basic qualities: sweet (detecting sugars for energy sources), sour (sensing acidity via hydrogen ions), salty (identifying sodium ions), bitter (alerting to potential toxins like alkaloids), and umami (recognizing savory amino acids such as glutamate).^[1]^[2] These tastes are mediated by taste buds, which are clusters of 50 to 150 receptor cells located on the tongue's papillae (fungiform, foliate, and circumvallate) and other oral surfaces, where taste receptor cells (TRCs) transduce chemical stimuli into neural signals via ion channels or G protein-coupled receptors (GPCRs).^[1]^[2] Signals from these receptors travel through cranial nerves VII (facial), IX (glossopharyngeal), and X (vagus) to the brainstem, thalamus, and gustatory cortex for processing, often integrating with smell (olfaction) and texture to form the overall flavor experience.^[1] Variations in taste perception arise from genetic factors, such as the number of fungiform papillae (with "supertasters" possessing more and heightened sensitivity to bitterness), age-related decline, and health conditions like zinc deficiency or infections.^[1] Beyond the mouth, taste receptors are expressed in the gastrointestinal tract, influencing digestion and metabolism, underscoring taste's evolutionary role in survival by promoting nutrient intake and avoiding hazards.^[2]

Physiology of Taste

Taste Buds and Detection

Taste buds are specialized sensory structures embedded in the epithelium of the tongue and oral cavity, primarily responsible for detecting chemical stimuli from food and beverages. They are housed within three main types of papillae: fungiform papillae, which are mushroom-shaped and distributed across the anterior two-thirds of the tongue, containing approximately 25% of the total taste buds; foliate papillae, located on the lateral edges of the tongue in vertical folds; and circumvallate papillae, forming an inverted V-shaped row at the posterior tongue, accounting for about 50% of all taste buds.^[3]^[4] These papillae elevate the taste buds toward the oral surface, optimizing contact with dissolved tastants, while filiform papillae, which cover much of the tongue's dorsum, lack taste buds and primarily aid in mechanical functions like food manipulation.^[2] Each taste bud forms an onion-shaped cluster of 50 to 100 epithelial cells, including gustatory cells (also known as taste receptor cells), which directly detect tastants; supporting cells (or sustentacular cells), which provide structural integrity and insulation; and basal cells, which serve as progenitor or stem cells for regeneration.^[5] Gustatory cells are elongated and polarized, extending from the basal lamina to the taste pore, while supporting cells wrap around them like glia, and basal cells reside at the periphery, contributing to cell renewal.^[6] These cell types work in concert to maintain the bud's functionality, with taste receptors located on the microvilli of gustatory cells protruding into the taste pore for stimulus interaction.^[7] Taste cells exhibit a rapid renewal cycle, with an average lifespan of 10 to 14 days in mammals, driven by continuous differentiation from basal progenitor cells to replace senescent cells.^[8] This turnover ensures sustained sensory acuity, as new gustatory and supporting cells migrate upward within the bud, maturing and integrating into the functional epithelium before being shed from the apical surface.^[9] The detection of taste stimuli begins when tastants—chemical compounds from food—dissolve in saliva and diffuse into the taste pore, where they bind to the microvilli of gustatory cells.^[10] This binding initiates the sensory process, with the narrow pore concentrating stimuli for efficient interaction at the cellular surface.^[6] Saliva plays a crucial role in taste perception by dissolving water-insoluble tastants into a liquid medium that can access the taste buds, facilitating their transport to microvilli.^[11] Additionally, saliva provides lubrication to reduce friction during mastication, allowing smooth bolus formation and prolonged contact with papillae, while its enzymes, such as α-amylase, initiate the breakdown of starches and other macromolecules, potentially modulating tastant release and intensity.^[12]^[13]

Taste Receptors and Transduction

Taste receptors are specialized proteins expressed in taste receptor cells within taste buds that detect chemical stimuli and initiate transduction, the process converting these stimuli into electrical signals for neural transmission. These receptors fall into two main categories: G-protein-coupled receptors (GPCRs) for sweet, bitter, and umami tastes, and ion channels for sour and salt tastes.^[14] The sweet and umami tastes are mediated by the T1R family of GPCRs, encoded by the TAS1R genes. Specifically, the heterodimer TAS1R2/TAS1R3 detects sweet compounds such as sugars and artificial sweeteners, while TAS1R1/TAS1R3 recognizes umami stimuli like L-amino acids.^[15] Upon ligand binding, these receptors activate the G-protein gustducin, whose Gβγ subunits stimulate phospholipase C β2 (PLCβ2), producing inositol 1,4,5-trisphosphate (IP3), which triggers calcium release from intracellular stores, activating the transient receptor potential channel M5 (TRPM5) and resulting in depolarization. A secondary pathway involving increased cAMP may also contribute by modulating ion channels.^[14] Bitter taste is detected by approximately 25-30 TAS2R genes encoding the T2R family of GPCRs, which respond to a diverse array of aversive compounds.80705-9) Activation of T2Rs couples to gustducin and phospholipase C β2 (PLCβ2), producing inositol 1,4,5-trisphosphate (IP3), which triggers calcium release from intracellular stores, activating the transient receptor potential channel M5 (TRPM5) and resulting in depolarization.^[14] Sour taste arises from acids and is transduced primarily through proton-gated ion channels, notably the polycystin-2-like 1 (PKD2L1) channel, often in complex with PKD1L3.^[16] Proton influx through these channels directly depolarizes type III taste cells, independent of G-protein signaling.^[17] Salt taste, particularly at low concentrations, involves the epithelial sodium channel (ENaC), an amiloride-sensitive ion channel that allows sodium ions to enter taste cells, directly causing depolarization.^[18] Higher salt levels may engage additional pathways, but ENaC remains central for attractive salty perception.^[19] Evidence from genetic knockout studies in mice confirms the specificity of these receptors. For instance, T1R2/T1R3 double knockouts exhibit complete loss of sweet taste preference, while T1R1/T1R3 knockouts abolish umami responses.^[15] Similarly, ablation of T2R-expressing cells or knockouts of T2R clusters eliminate behavioral and neural responses to specific bitter compounds.^[20] For sour taste, PKD2L1 knockout mice show significantly reduced acid-evoked responses, though residual detection suggests additional mechanisms.^[21] ENaC subunit knockouts impair low-salt attraction, underscoring its role.^[22]

Basic Tastes

Sweetness

Sweetness is one of the basic human taste modalities, characterized by the perception of sugars and other sweeteners as a pleasant sensation that typically evokes a positive hedonic response.^[23] This perception primarily arises from the detection of carbohydrates, which serve as a key indicator of caloric availability in foods.^[24] The sweet taste is elicited by a variety of natural ligands, including monosaccharides such as glucose and fructose, and disaccharides like sucrose, which are common in fruits, honey, and other plant-derived sources.^[25] Artificial sweeteners, such as aspartame and saccharin, also activate the same perceptual pathway despite their non-caloric nature, allowing them to mimic the taste of natural sugars without providing energy.^[26] These compounds bind to the human sweet taste receptor, a G protein-coupled receptor (GPCR) formed by the heterodimer of taste receptor type 1 member 2 (T1R2) and member 3 (T1R3), initiating a signaling cascade that leads to taste cell depolarization and neural transmission.^[26] In 2025, the high-resolution structure of the T1R2/T1R3 receptor was elucidated, providing insights into sweet ligand binding.^[27] This receptor mechanism shares the general GPCR transduction pathway with umami taste detection.^[28] Evolutionarily, the preference for sweetness is thought to have developed as an adaptive trait to identify and favor energy-dense foods, such as ripe fruits and nectar, which were crucial for survival in ancestral environments where carbohydrates provided essential fuel.^[24] This innate attraction to sweet flavors persists across species and human populations, promoting the consumption of nutrient-rich, non-toxic options over potentially harmful alternatives.^[29] The intensity of sweet taste perception follows principles described by the Weber-Fechner law, where the just-noticeable difference in sweetness is proportional to the magnitude of the stimulus, allowing for scaling of perceived intensity relative to concentration.^[30] For sucrose, the detection threshold—the lowest concentration at which sweetness is reliably perceived—is approximately 0.01 M (about 3.4 g/L), varying slightly with factors like age and individual sensitivity.^[31] Cultural preferences for sweetness exhibit variations influenced by dietary habits and environmental factors; for instance, populations with traditional high-carbohydrate diets, such as those in parts of Asia, often show heightened acceptance of intense sweetness compared to groups accustomed to lower-sugar intakes in certain Western or Mediterranean contexts.^[32] These differences highlight how repeated exposure and cultural norms can modulate the universal appeal of sweet taste without altering the underlying biology.^[33]

Sourness

Sourness is one of the basic tastes, elicited by the presence of acids in food and beverages, where the sensation is primarily triggered by hydrogen ions (H⁺) interacting with taste receptor cells.^[34] In humans, this perception occurs in type III taste receptor cells (TRCs) located in taste buds, which detect protons through specialized ion channels.^[34] The primary receptor mechanism for sour taste involves OTOP1, a proton-selective ion channel expressed in type III TRCs, which allows H⁺ influx to depolarize the cell and initiate transduction. Although acid-sensing ion channels (ASICs) were initially proposed as candidates due to their sensitivity to extracellular acidification, genetic and pharmacological studies have shown they play a minimal role in gustatory sour detection, as their inhibition does not significantly impair sour responses.^[34] This OTOP1-mediated process distinguishes sourness from other tastes by directly coupling proton entry to neural signaling without requiring G-protein-coupled receptors. Human detection of sourness typically begins at pH levels below 4, with a perceptual threshold around pH 4 for strong acids like HCl, though sensitivity can vary by acid type and individual factors.^[34] The intensity of the sour sensation correlates directly with hydrogen ion concentration, increasing logarithmically as pH decreases, which allows for graded responses from mild tartness to intense acidity.^[34] Biologically, sour taste serves as an evolutionary warning system, signaling potential spoilage in foods through elevated acidity from microbial fermentation, thereby deterring ingestion of harmful substances.^[35] It also aids in identifying ripeness in fruits, where increasing acid content during maturation (often alongside sugars) indicates nutritional availability, as seen in primate preferences for mildly sour, ripe produce rich in vitamins.^[35] Common examples include citric acid, which imparts the sharp sourness in lemons and other citrus fruits due to its low pKa values (3.13, 4.76, 6.40), and lactic acid, responsible for the tangy sourness in yogurt from bacterial fermentation.^[36] In beverages, sourness often interacts with sweetness, where added sugars like sucrose can mask or suppress acidic perceptions, as observed in lemonade where sucrose reduces the intensity of citric acid-induced sourness while enhancing overall palatability.^[37]

Saltiness

Saltiness is one of the five basic tastes, characterized by the perception of sodium chloride (NaCl) and other salts, particularly at low to moderate concentrations where it elicits an attractive, appetitive response that encourages consumption.^[18] This sensation arises primarily from the detection of sodium ions (Na⁺) in the oral cavity, serving as a cue for essential mineral intake.^[38] The primary mechanism for saltiness perception involves amiloride-sensitive epithelial sodium channels (ENaC), which are expressed in specific taste receptor cells and allow Na⁺ influx, leading to membrane depolarization and neurotransmitter release.^[39] At low concentrations, this ENaC-mediated pathway drives the pleasurable aspect of salt taste. However, at higher concentrations, salt activates alternative aversive pathways, recruiting bitter- and sour-sensing taste cells, which can produce unpleasant sensations.^[40] This dual mechanism helps balance attraction to beneficial levels with aversion to excess.^[19] The human detection threshold for NaCl is approximately 3 mM (0.003 M), below which saltiness is not reliably perceived, though individual variability exists based on factors like age and diet.^[41] Recognition thresholds, where the taste is identified as salty, are slightly higher, around 0.015-0.02 M.^[41] Physiologically, salt taste plays a critical role in maintaining electrolyte homeostasis by signaling sodium availability, which is vital for fluid balance, nerve function, and muscle contraction.^[42] It also regulates appetite for sodium, with depletion states enhancing sensitivity to promote intake and restore balance.^[43] Excessive salt intake is linked to hypertension through mechanisms like increased blood volume and vascular resistance, contributing to cardiovascular risks.^[44] As a variation, potassium chloride (KCl) serves as a common salt substitute, mimicking some saltiness via cation detection but often imparting bitter or metallic off-notes at higher levels, which can be mitigated in mixtures with NaCl.^[45]

Bitterness

Bitterness is recognized as one of the five basic tastes, eliciting an aversive sensation that serves as a warning against potentially harmful substances.^[46] This taste arises from the activation of approximately 25 functional type 2 taste receptors (TAS2Rs), a subfamily of G protein-coupled receptors (GPCRs) expressed on the apical surface of taste receptor cells within taste buds.^[46] Recent studies (as of 2024) have identified dual binding sites in TAS2R receptors, enhancing understanding of ligand diversity.^[47] These receptors enable the detection of a remarkably diverse array of chemical compounds, far broader than those activating other taste modalities, reflecting the evolutionary pressure to identify toxins.^[48] The TAS2R receptors function through a common transduction mechanism: upon binding a bitter ligand, they couple to G proteins, primarily gustducin, triggering a signaling cascade that increases intracellular calcium and depolarizes the taste cell, ultimately releasing neurotransmitters to afferent nerves.^[46] This family detects structurally varied molecules, including alkaloids like quinine and caffeine, as well as phenolic compounds prevalent in plant tissues.^[48] Human sensitivity to bitterness is exceptionally acute, with detection thresholds for certain poisons reaching as low as 0.008 mM for quinine, allowing rapid identification of even trace amounts of hazardous substances.^[49] From an evolutionary standpoint, the bitterness detection system likely developed as a protective adaptation against plant-derived toxins, many of which are bitter alkaloids or phenols that could cause illness or death if ingested.^[50] This is evidenced by the correlation between TAS2R gene repertoire size and dietary reliance on plants across species, underscoring bitterness's role in foraging safety for early humans and other vertebrates.^[51] Prominent examples of bitter compounds include caffeine, found in coffee and tea, which activates multiple TAS2Rs such as TAS2R7 and TAS2R10, and denatonium benzoate, the most intensely bitter substance known, detectable at concentrations as low as 10 parts per billion and recognized by at least eight TAS2R subtypes including TAS2R4 and TAS2R16.^[48]^[52] Although inherently aversive, human perception of bitterness can adapt through repeated exposure, leading to tolerance and even acquired preference for bitter beverages like coffee and tea; for instance, consistent consumption of green tea polyphenols such as epigallocatechin gallate reduces perceived bitterness intensity over time via changes in salivary protein profiles and hedonic evaluation.^[53] This learned adaptation often links the initial unpleasantness to rewarding physiological effects, such as caffeine's stimulant properties, facilitating cultural acceptance of these foods.^[54]

Umami (Savoriness)

Umami is the savory taste quality primarily elicited by the amino acid L-glutamate and enhanced by 5'-ribonucleotides such as inosinate monophosphate (IMP) and guanosine monophosphate (GMP), often perceived as meaty, brothy, or richly flavorful.^[55] This taste was first scientifically identified in 1908 by Japanese chemist Kikunae Ikeda, who isolated glutamate from kombu seaweed as the compound responsible for the distinctive savoriness in dashi broth.^[56] The umami taste is mediated by the heterodimeric G-protein-coupled receptor T1R1/T1R3, where glutamate binds to the Venus flytrap domain of T1R1, triggering conformational changes that activate downstream signaling.^[57] IMP and GMP bind to a separate site on T1R3, allosterically enhancing glutamate's affinity and amplifying the taste response by up to eightfold, a synergy unique to this receptor.^[58] Human detection thresholds for umami are relatively low, with monosodium glutamate (MSG) recognized at concentrations around 1 mM (0.001 M), allowing it to function effectively as a flavor enhancer in foods.^[59] Evolutionarily, umami serves as a sensory signal for the presence of proteins and amino acids in the diet, promoting intake of nutrient-dense foods like meat, fish, and fermented products to support protein nutrition.^[60] Umami exhibits synergies with other tastes, intensifying saltiness and sweetness in mixed stimuli to enhance overall palatability, as seen in culinary combinations like soy sauce or cheese.^[61] Psychophysical studies, including multidimensional scaling, demonstrate umami's perceptual independence, with it clustering distinctly from salty and sweet tastes in sensory space, confirming its status as a unique basic taste quality.^[62]

Other Oral Sensations

Pungency and Irritation

Pungency and irritation in the oral cavity arise from chemesthetic sensations, which are chemical activations of sensory nerves that produce perceptions of burning, stinging, or spicy heat, distinct from the five basic tastes. These sensations are primarily mediated by transient receptor potential vanilloid 1 (TRPV1) channels, a type of ion channel expressed in trigeminal nerve endings and epithelial cells of the mouth and nasal passages. TRPV1 is activated by pungent compounds such as capsaicin, leading to an influx of cations that depolarizes sensory neurons and triggers nociceptive signals interpreted as irritation or warmth.^[63]^[64] Unlike gustatory pathways, these chemesthetic responses occur via the trigeminal nerve (cranial nerve V), which innervates the oral mucosa and conveys non-thermal sensations that mimic heat, even at ambient temperatures around 22–37°C. This creates an illusory sensation of burning without actual temperature elevation, as TRPV1 is also sensitive to physical heat above 43°C. For instance, capsaicin, the primary alkaloid in chili peppers (Capsicum spp.), binds to specific sites on TRPV1's intracellular domain, eliciting a dose-dependent burning sensation starting at concentrations as low as 1–5 μM. Similarly, piperine, the main pungent compound in black pepper (Piper nigrum), activates TRPV1 but through a distinct structural mechanism, interacting with the channel's pore-forming S6 segment rather than the capsaicin-binding pocket, resulting in a less potent but comparable spicy irritation with an EC50 of approximately 3.3 μM.^[63]^[64]^[65] The intensity of pungency from capsaicinoids is quantified using the Scoville Heat Units (SHU) scale, originally developed in 1912 by diluting pepper extracts in sugar water until the heat is undetectable by trained panelists; modern measurements employ high-performance liquid chromatography to assess capsaicin content, with 1 ppm equating to 16 SHU. This scale ranges from 0 SHU for mild bell peppers (lacking capsaicin) to about 16 million SHU for pure capsaicin, though extreme varieties like the Carolina Reaper reach 2.2 million SHU. In plants, capsaicinoids evolved as a chemical defense mechanism in Capsicum species, deterring mammalian herbivores and fungal pathogens while allowing seed dispersal by birds, which lack TRPV1 receptors and thus perceive no pungency; this trait likely emerged around 20 million years ago in the Solanaceae family.^[66]^[67]^[68] In culinary applications, pungency enhances food flavor by stimulating salivation, modulating aroma release, and amplifying perceptions of saltiness and umami at low doses, thereby increasing palatability and appetite without adding calories. Prolonged or repeated exposure to these irritants leads to desensitization, where perceived intensity diminishes due to TRPV1 channel inactivation and reduced neuronal responsiveness; this effect can onset within minutes of stimulation at concentrations above 33 μM and persist for days, though it is partially reversible through stimulus-induced recovery with equivalent or higher doses after short intervals.^[69]^[70]^[71]

Coolness and Temperature Effects

Cooling sensations in the oral cavity are primarily mediated by the transient receptor potential melastatin 8 (TRPM8) channel, a thermosensitive ion channel expressed in sensory neurons innervating the tongue and oral mucosa.^[72] Menthol, a compound found in mint plants, activates TRPM8 by binding to it, triggering an influx of cations that depolarizes neurons and produces a perceived coolness even at neutral temperatures.^[73] This menthol-induced cooling is distinct from actual temperature reduction but mimics cold stimuli, contributing to the refreshing quality of mint-flavored foods and beverages.^[74] Temperature significantly modulates basic taste perceptions through interactions with taste receptor cells and neural signaling. Warmer temperatures, typically above body temperature, enhance the intensity of sweet and umami tastes by increasing the activity of TRPM5 channels in type II taste cells, which amplify gustatory signals.^[75] Conversely, colder temperatures suppress bitterness and, to a lesser extent, sweet and umami perceptions, likely by reducing receptor sensitivity and slowing transduction processes.^[76] These effects are evident in everyday experiences, such as how warm chocolate intensifies sweetness or chilled beer mellows its bitter aftertaste.^[77] The optimal temperature for detecting and perceiving most tastes falls within 20–30°C, where detection thresholds for sweet, sour, salty, bitter, and umami are lowest, forming a U-shaped sensitivity curve.^[78] At this range, flavor profiles are most balanced and vivid, as seen in room-temperature fruits or beverages served slightly cool.^[79] Thermosensitive TRP channels, including TRPM8 for cooling below 28°C and TRPV1 for warming above 43°C, underpin these oral temperature sensations by gating ion flow in response to thermal changes in the mucosa.^[80] For instance, the cooling from mint integrates with taste via TRPM8 co-expression in oral afferents, while in ice cream, moderate cold (around 0–10°C) combines with fat texture to enhance creaminess and subtle sweetness before full melting boosts flavor release.^[81]^[82] Extreme temperatures override taste perception by activating nociceptive pathways, shifting focus from gustation to pain. Temperatures below 5°C or above 50°C engage TRPA1 and other channels, eliciting burning or stinging sensations that dominate oral input and mask finer tastes.^[83] This physiological limit protects against thermal injury but can alter flavor enjoyment, as in scalding hot soups where pain eclipses savoriness. TRP channels involved in these extremes overlap with those sensing pungency, such as capsaicin-induced heat via TRPV1.^[84]

Astringency and Numbness

Astringency refers to a dry, puckering, and rough tactile sensation in the mouth, distinct from the five basic tastes and primarily triggered by dietary polyphenols such as tannins. These compounds, abundant in sources like red wine, black tea, and unripe fruits, interact with salivary proteins to elicit the effect. The primary mechanism involves the binding and precipitation of proline-rich proteins (PRPs) and other salivary components by polyphenols, which reduces oral lubrication and disrupts the protective salivary pellicle on mucosal surfaces. This leads to increased friction between oral tissues, perceived as dryness and constriction. Mucins, another salivary protein family, may also contribute by aggregating with polyphenols, further impairing the mouth's slippery coating.^[85]^[86]^[87] Unlike gustatory sensations, astringency is mediated through somatosensory pathways of the trigeminal nerve, involving mechanoreceptors that detect changes in oral texture and chemoreceptors sensitive to mucosal alterations. This non-taste mechanism explains why astringency can persist or build over time, often intensifying with repeated exposure due to cumulative protein binding. In red wine, for instance, tannins from grape skins and seeds cause a velvety-to-rough mouthfeel proportional to their concentration, degree of polymerization, and galloylation. Similarly, tea polyphenols produce a comparable drying effect, particularly in oversteeped brews. Evolutionarily, tannins likely evolved in plants as anti-herbivory defenses, with astringency serving as an aversive signal to deter consumption of immature or nutrient-poor foliage by reducing palatability and digestibility.^[87]^[88]^[89] Astringency measurement typically employs subjective sensory evaluation by trained panels using scales that capture mouthfeel attributes. Common methods include time-intensity (TI) profiling, where participants rate sensation peak and duration on a structured scale (e.g., 0-10 for intensity), or general labeled magnitude scales (gLMS) to quantify puckering and dryness. These approaches provide reliable data for food science, though individual variability arises from salivary flow rates and protein composition. In culinary contexts, astringency enhances flavor complexity by contrasting with sweetness or fat, but excessive levels can mask desirable notes.^[87]^[85] Numbness in the oral cavity manifests as a tingling paresthesia or anesthetic-like desensitization, often accompanied by a vibrating buzz, and is elicited by certain alkaloids rather than taste receptors. Hydroxy-α-sanshool, the key compound in Szechuan pepper (Zanthoxylum species), induces this by selectively inhibiting two-pore domain potassium channels (K2P channels like KCNK3, KCNK9, and KCNK18) in sensory neurons. This inhibition reduces potassium efflux, causing membrane depolarization and hyperexcitability in both nociceptive (TRPV1-positive) and mechanoreceptive (TrkC-positive) fibers, resulting in anomalous firing rates equivalent to 50 Hz vibrations. The effect mimics low-dose local anesthetics like lidocaine, producing transient numbness without full blockade.^[90]^[91] This somatosensory response is conveyed via trigeminal nerve pathways, activating subsets of cutaneous and lingual afferents to create multimodal irritation distinct from pungency or coolness. In Sichuan cuisine, sanshool from red or green huajiao peppers delivers a signature ma (numbing) sensation that pairs with la (spicy) from capsaicin, amplifying overall flavor through cross-modal interactions. Other spices, such as those containing related alkylamides, produce milder versions, but sanshool's potency stems from its lipophilic structure enabling rapid neuronal penetration. While its evolutionary role as a plant defense is hypothesized based on secondary metabolite patterns, direct evidence links it primarily to sensory deterrence in herbivores.^[90]^[92] Sensory evaluation of numbness follows similar protocols to astringency, using descriptive scales for tingling intensity, duration, and quality in panel tests. Time-intensity methods track the buzz's onset (rapid, within seconds) and fade (up to minutes), often integrated with electromyography to correlate perceived vibration with muscle activity. These tools aid in standardizing spice formulations, where numbness contributes to perceptual complexity without overwhelming taste.^[90]

Fat Perception and Other Emerging Tastes

Fat perception has emerged as a potential sixth basic taste modality, distinct from the traditional five, based on molecular evidence involving specific receptors in taste bud cells. The fatty acid translocase CD36, identified as a key receptor for long-chain fatty acids, facilitates the detection of free fatty acids released from dietary fats by lingual lipases. This receptor's role was first demonstrated in rodents, where CD36 gene transfer conferred gustatory sensitivity to fatty acids, and subsequent human studies confirmed its expression in taste buds and association with oral fat detection. In 2015, the term "oleogustus" was proposed to describe this unique fat taste quality, characterized as a distinct oral sensation beyond texture or aroma. As of 2025, fat is still considered a potential but debated sixth basic taste. Detection thresholds for fat taste are notably low, with linoleic acid, a common polyunsaturated fatty acid, detectable at concentrations around 1 mM in human subjects, indicating high sensitivity comparable to other basic tastes.^[93] However, debates persist on whether fat constitutes a true taste or primarily contributes through textural attributes like creaminess and viscosity, as emulsified fats can elicit sensations via somatosensory pathways rather than purely chemosensory ones.^[94] Recent research continues to explore evidence for fat as a primary taste. Starchiness represents another emerging taste quality, perceived as a creamy or pasty sensation from complex carbohydrates like maltodextrins, which are breakdown products of starches via salivary amylase.^[95] This perception arises from the interaction of maltodextrins with oral receptors, potentially involving GPR40 and GPR120, which are G-protein-coupled receptors typically associated with fatty acid sensing but also responsive to carbohydrate-derived signals that enhance mouthfeel.^[96] Unlike simple sweetness from glucose, starchiness evokes a distinct, satiating quality that influences food preferences for starchy items. Calcium perception operates through the calcium-sensing receptor (CaSR), a G-protein-coupled receptor expressed in type II taste cells, enabling detection of calcium ions at physiological concentrations and contributing to a subtle mineral-like taste.^[97] Similarly, metallic tastes from copper and iron ions are mediated by interactions with zinc transporters, such as ZIP4, which facilitate ion entry into taste cells and trigger aversive sensations often described as bitter-metallic. Kokumi, or "heartiness," enhances the intensities of basic tastes like umami through CaSR activation by γ-glutamyl peptides and other compounds, creating a richer, mouth-filling perception without a distinct flavor of its own.^[98] This modality, prominent in aged cheeses and fermented foods, amplifies overall palatability via calcium-sensing mechanisms in the oral cavity.^[99]

Neural Pathways and Perception

Peripheral Nerve Supply

The peripheral nerve supply for taste sensation in humans is mediated primarily by three cranial nerves: the facial nerve (cranial nerve VII), the glossopharyngeal nerve (cranial nerve IX), and the vagus nerve (cranial nerve X). These nerves carry gustatory afferents from taste buds located on the tongue, soft palate, and pharynx to the central nervous system. The facial nerve, via its chorda tympani branch, innervates the anterior two-thirds of the tongue, providing sensory input from fungiform papillae.^[100]^[4] The glossopharyngeal nerve supplies the posterior one-third of the tongue, including the circumvallate and foliate papillae.^[100]^[4] The vagus nerve, through its superior laryngeal branch, innervates the epiglottis and a small region of the pharynx, contributing to taste perception in the upper airway.^[100]^[101] Taste buds, as specialized sensory structures embedded within lingual papillae, receive direct innervation from these cranial nerves, with nerve fibers penetrating the basal region to synapse with receptor cells. The trigeminal nerve (cranial nerve V) does not directly mediate taste but provides somatosensory input, including pain and temperature sensations, from the oral mucosa; this integration can influence perceived taste intensity through synesthetic effects, such as enhanced pungency from irritants.^[4]^[102] Damage to these nerves can result in zonal ageusia or dysgeusia. For instance, injury to the chorda tympani branch of cranial nerve VII, often occurring during middle ear surgery, leads to taste loss on the anterior tongue, though adaptation may occur over time via remaining nerves.^[103]^[104] Lesions of cranial nerve IX affect the posterior tongue, causing taste loss, while vagus nerve damage is rarer but can alter epiglottic sensitivity.^[100]^[105] This innervation pattern exhibits evolutionary conservation across vertebrates, where cranial nerves VII, IX, and X consistently provide gustatory afferents to taste receptor organs, reflecting an ancient origin in early chordates for chemosensory detection essential to feeding and survival.^[106]^[107] In mammals and other vertebrates, the reliance on these nerves for maintaining taste bud integrity underscores their fundamental role, with nerve transection leading to taste bud degeneration in denervated regions.^[108]

Central Processing in the Brain

Taste signals from the peripheral nerves first synapse in the nucleus of the solitary tract (NTS) in the brainstem, serving as the primary relay station for gustatory information.^[109] The NTS exhibits a rostro-caudal organization, with rostral regions processing gustatory inputs and caudal areas handling visceral afferents, allowing for initial integration of taste with other sensory modalities.^[110] From the NTS, projections ascend to the parvocellular division of the ventroposteromedial nucleus (VPMpc) in the thalamus, which acts as a relay to the primary gustatory cortex located in the insula and adjoining frontal operculum.^[109] This cortical region processes basic taste qualities, with neurons responding selectively to specific stimuli like sweet or bitter. Higher-order processing involves integration of gustatory signals with olfactory inputs in the orbitofrontal cortex (OFC), where flavor perception emerges as a multisensory construct.^[111] The OFC evaluates the hedonic value of tastes, modulating responses based on context and prior experience.^[112] Two primary theories explain taste coding in these central pathways: the labeled line theory, which posits dedicated neural pathways for each taste quality (e.g., sweet-specific neurons from receptor to cortex), supported by genetic studies of taste receptors; and the across-fiber pattern theory, which suggests quality is encoded by distributed activity patterns across broadly tuned neurons.^[113] Evidence from electrophysiological recordings in primates favors a hybrid model, with labeled lines at peripheral levels giving way to pattern coding centrally.^[114] Affective and reward aspects of taste are processed in limbic structures, including the amygdala and ventral striatum, which assign emotional valence and drive ingestive behaviors. The basolateral amygdala encodes taste palatability, while the central nucleus influences autonomic responses; projections to the ventral striatum, particularly the nucleus accumbens, facilitate reward signaling.^[109] For sweet tastes, dopamine release in the ventral striatum reinforces preference and motivation, as demonstrated in rodent studies where sweet stimuli elicit phasic dopamine bursts linked to hedonic "liking." Functional magnetic resonance imaging (fMRI) studies in humans reveal distinct activation patterns for umami compared to sweet, with umami eliciting stronger responses in the anterior insula and OFC, highlighting specialized central representations for this savory quality.^[115]

Variations in Taste Perception

Genetic and Individual Differences

Individual differences in taste perception are significantly influenced by genetic variations, particularly in bitter taste receptors. The TAS2R38 gene encodes a bitter taste receptor that exhibits polymorphisms affecting sensitivity to compounds like phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). Homozygous carriers of the functional PAV haplotype (PAV/PAV) display heightened sensitivity to PTC bitterness, detecting it at concentrations over 400-fold lower than non-tasters (AVI/AVI), while heterozygotes show intermediate responses.00109-0) These genetic variants contribute to the classification of individuals as supertasters, who experience intensified bitter tastes, medium tasters, or non-tasters. The genetic basis of bitter perception involves multiple TAS2R receptors, but TAS2R38 is a primary determinant for thiourea-related bitterness.00109-0) Population prevalence of these phenotypes is approximately 25% supertasters, 50% medium tasters, and 25% non-tasters, based on PROP/PTC sensitivity assessments.^[116] PROP tasting serves as a reliable proxy for overall taste sensitivity, as supertasters not only perceive PROP as intensely bitter but also exhibit elevated responses across sweet, salty, sour, and umami qualities, along with heightened oral somatosensation.^[117] Age and gender further modulate taste sensitivity. Taste function declines notably after age 60, with significant reductions in detection of sweet, sour, and bitter tastes compared to younger adults (20-39 years), attributed to decreased taste bud density and salivary changes.^[118] Females generally demonstrate greater taste sensitivity than males, particularly for bitter and sweet stimuli in older age groups (≥60 years).^[118] Cultural and environmental factors, including dietary exposure, shape taste preferences despite genetic predispositions. For instance, Asian populations, who have a higher prevalence of supertasters (around 55%), show reduced aversion to bitter foods through familiarity with bitter-tasting vegetables like Brassica species in traditional cuisines, leading to greater acceptance compared to Western groups.^[119]^[120] Twin studies indicate moderate heritability for taste preferences, with approximately 50% of variation in sweet taste liking attributable to genetic factors, the remainder influenced by shared and unique environmental experiences.^[121]

Taste Across Species

Taste perception varies widely across species, reflecting evolutionary adaptations to dietary needs and environmental pressures. In mammals, taste systems are tailored to specific feeding ecologies; for instance, cats exhibit a complete loss of sweet taste detection due to pseudogenization of the Tas1r2 gene through a 247-base pair deletion in exon 3, rendering them indifferent to sugars as obligate carnivores.^[122] Rodents, in contrast, display heightened sensitivity to bitter compounds, supported by an expanded repertoire of approximately 35 Tas2r bitter taste receptor genes, which enables detection of a broad array of potentially toxic plant alkaloids in their omnivorous diets.^[123] This intraspecific variation among mammals highlights how taste evolves to prioritize toxin avoidance or nutrient seeking based on lifestyle. Birds generally possess a simplified taste apparatus compared to mammals, with reduced numbers of taste buds—ranging from about 24 in pigeons to 240–360 in chickens—concentrated primarily on the tongue and palate.^[124] Their taste system emphasizes umami detection via T1R1/T1R3 receptors, which respond to amino acids abundant in seeds and insects, aiding in the identification of protein-rich foods essential for granivorous and insectivorous species.^[125] Insects like Drosophila melanogaster employ a distinct gustatory system, utilizing around 60 gustatory receptors (Grs) expressed in sensilla on the legs, wings, and proboscis; specific Grs such as Gr5a and Gr64a mediate sweet taste for sugars, while subsets like Gr66a respond to bitter stimuli, allowing precise evaluation of food quality during foraging.^[126] In fish, taste buds are distributed across the body surface, integrating with other sensory modalities such as electroreception in species like catfish and mormyrids to enhance prey detection in aquatic environments.^[127] This multisensory integration allows fish to combine chemical cues from taste with electric field disturbances for efficient hunting. Evolutionary divergences in taste often align with dietary shifts; carnivorous mammals, including sea lions and dolphins, have lost functional umami receptors (Tas1r1 pseudogenization), as meat provides ample amino acids without needing specialized detection.^[128] Such losses underscore how relaxed selective pressure from specialized diets leads to taste receptor degeneration across lineages. Model organisms like zebrafish (Danio rerio) are pivotal in taste research due to their remarkable regenerative capacity; taste buds fully renew every few weeks through Wnt and Fgf signaling pathways, providing insights into epithelial cell turnover absent in mammals.^[129] Unlike humans, where genetic variations in taste receptors like TAS2R38 influence individual bitter sensitivity, these animal models reveal broader phylogenetic patterns in taste adaptation.^[123]

Clinical and Applied Aspects

Taste Disorders

Taste disorders, collectively termed gustatory dysfunctions, refer to pathological impairments in the perception of taste, distinct from olfactory issues though often overlapping. These conditions can profoundly affect daily life by altering food enjoyment and nutritional intake. The primary types include ageusia, characterized by a complete loss of taste sensation; hypogeusia, involving reduced taste sensitivity; dysgeusia, marked by distorted or unpleasant taste perceptions such as a persistent metallic flavor; and parageusia (or phantogeusia), the experience of phantom tastes without external stimuli.^[130]^[131] The etiology of taste disorders is diverse, encompassing neurological damage to peripheral nerves or central neural pathways, as seen in conditions like Bell's palsy, stroke, or head trauma.^[132] Infections, particularly viral ones such as COVID-19, frequently trigger post-infectious hypogeusia or ageusia, with 40% to 50% of affected patients reporting symptoms. Most post-infectious cases recover within 7 days to 3 months, with over 80% regaining function by 3 months; however, as of 2025, persistent taste disorders affect approximately 10-20% of individuals with long COVID.^[132]^[133] Nutritional deficiencies, especially zinc, contribute to taste impairment by affecting taste bud regeneration, while iatrogenic causes include chemotherapy, radiation therapy to the head and neck, and certain medications like ACE inhibitors or antibiotics.^[130]^[131] Diagnosis typically involves clinical history, physical examination, and specialized tests to quantify taste thresholds. Electrogustometry applies electrical stimulation to the tongue to assess nerve function and detect unilateral deficits, while filter paper tests use strips impregnated with solutions of salt, sweet, sour, and bitter compounds to evaluate overall gustatory sensitivity.^[131]^[130] Management focuses on addressing reversible causes, with treatments tailored to the underlying pathology. Zinc supplementation, such as 140 mg daily of zinc gluconate, has demonstrated improvement in hypogeusia linked to deficiency, and alpha-lipoic acid (600 mg daily) may aid recovery in some cases.^[130] For persistent parageusia, psychological counseling or cognitive behavioral therapy can mitigate distress from phantom sensations.^[131] Discontinuing offending medications or treating infections promptly is essential when applicable.^[132] Prevalence increases with age, affecting about 19% of adults aged 40 and older and 27% of those 80 and older, often underreported due to overlap with smell loss.^[132] Isolated taste disorders occur in roughly 3% to 5% of clinic-referred cases of sensory complaints, with notable surges during viral pandemics like the 2020s COVID-19 outbreaks.^[134]^[132] The impact of taste disorders extends beyond sensory loss, often leading to malnutrition from reduced appetite and food avoidance, heightened risk of depression, and compromised quality of life, particularly in vulnerable populations like the elderly.^[132]^[131]

Acquired Tastes and Aftertaste

An acquired taste develops when an initially unpleasant flavor, such as the bitterness of coffee or the astringency of alcoholic beverages, becomes enjoyable through repeated exposure and learning processes.^[135] This phenomenon contrasts with innate preferences for sweet or umami tastes, reflecting adaptive changes in sensory and emotional responses to potential foods.^[135] For instance, durian fruit, known for its pungent odor and creamy texture, is often rejected at first but embraced in Southeast Asian cultures after habitual consumption.^[135] The primary mechanisms underlying acquired tastes include the mere exposure effect, where repeated encounters with a stimulus enhance liking without conscious reinforcement, as demonstrated in seminal psychological experiments.^[136] Neural habituation in the amygdala to repeated food cues can diminish initial responses, potentially facilitating preference formation through reduced reactivity.^[137] Cultural and social factors further reinforce these shifts, as observed in the learned acceptance of spicy or fermented foods across diverse societies.^[135] These processes often link to brain reward pathways, integrating with central taste processing to associate flavors with positive outcomes like satiety or social bonding.^[138] Aftertaste refers to the persistent flavor sensation that remains in the mouth after swallowing, arising from the slow dissipation of volatile aroma compounds or the prolonged activation of taste receptors by certain tastants.^[139] For example, the umami elicited by monosodium glutamate (MSG) produces a lingering savory note lasting over 30 seconds, longer than many other basic tastes due to sustained receptor binding.^[139] This persistence contributes to overall flavor complexity, distinguishing it from fleeting initial perceptions. Aftertaste is quantitatively assessed using time-intensity profiles, a sensory evaluation method that plots perceived intensity against time to map onset, peak, and decay phases of a flavor.^[139] In umami stimuli like MSG combined with nucleotides, profiles reveal extended plateaus at maximum intensity (16–20 seconds) followed by aftertastes of 50–96 seconds.^[139] In the food industry, aftertaste manipulation is a key aspect of flavor design, where umami enhancers like MSG are incorporated to create balanced, memorable profiles in products such as soups, snacks, and ready meals, improving palatability and consumer satisfaction.^[140] This approach allows for reduced salt or sugar while maintaining desirable lingering effects, as seen in low-sodium formulations.^[140]

Historical and Scientific Development

Early Discoveries

The understanding of taste as a distinct sensory modality began in ancient times, with the Greek philosopher Aristotle identifying four primary taste qualities—sweet, sour, salty, and bitter—in his work De Anima, where he described them as arising from interactions between food substances and the tongue's humoral qualities.^[141] These qualities were thought to reflect the four elements (earth, air, fire, water), and notably excluded what would later be recognized as umami, limiting the framework to these elemental associations without a savory dimension. Aristotle's classification dominated Western thought for over two millennia, influencing perceptions of flavor as a balance of opposites rather than a complex perceptual system. In the 19th century, advances in microscopy enabled the first detailed observations of the tongue's surface structures, with papillae identified as early as the 1820s through early microscopic examinations that revealed their role in sensory reception.^[142] This period also saw the separation of chemical senses, as physiologists distinguished taste from smell based on their distinct peripheral mechanisms and neural pathways, moving away from earlier conflations where flavors were largely attributed to olfactory influences. Key to this era was the 1867-1868 description of taste buds by German anatomists Christian Lovén and Gustav Schwalbe, who identified these flask-shaped structures embedded in the papillae as the primary sites for taste detection, marking a shift toward anatomical precision in sensory physiology.^[143] The 20th century brought further refinements, beginning with the 1908 identification of umami by Japanese chemist Kikunae Ikeda, who isolated glutamic acid (as monosodium glutamate, or MSG) from kombu seaweed as the source of a savory taste distinct from the four traditional qualities, coining the term "umami" to describe it.^[144] By the 1960s, receptor theories began to emerge, building on earlier conceptual models like Hans Henning's taste prism from the 1920s, which visualized taste qualities as points on a geometric structure to illustrate their perceptual relationships and mixtures, though it was later critiqued for oversimplification.^[145] Nobel laureate Georg von Békésy contributed significantly during this decade, applying biophysical methods from his auditory research to taste; his 1964 duplexity theory proposed that taste sensations form two grouped categories (e.g., bitter-warm-sweet vs. sour-cold-salty) based on electrical and thermal stimulation experiments, highlighting parallels in sensory funneling mechanisms across modalities.^[146]

Modern Research Advances

In the early 2000s, significant progress in taste research came from the cloning and characterization of key taste receptor genes, including the TAS1R family for sweet and umami detection and the TAS2R family for bitter perception.^[147] These discoveries, achieved through positional cloning and functional expression studies in heterologous systems, revealed G-protein-coupled receptors as central mediators of taste transduction, enabling targeted genetic manipulations in model organisms. Bachmanov and colleagues further elucidated the genetic basis of taste variation by mapping these receptors and linking polymorphisms to behavioral responses in mice. Advancing beyond the classical five tastes, research in the 2010s confirmed fat as a distinct gustatory quality, termed oleogustus, based on the oral perception of non-esterified fatty acids. This proposal stemmed from psychophysical studies showing that medium- and long-chain fatty acids evoke a unique mouthfeel and flavor, distinct from texture or aroma.^[148] Concurrently, investigations into CD36, a scavenger receptor expressed in taste bud cells, demonstrated its role in fatty acid binding and signaling, with knockout studies in rodents revealing diminished fat preference and detection thresholds.^[149] Optogenetic techniques have revolutionized the study of taste cellular mechanisms since the mid-2010s, allowing precise manipulation of specific taste cell types in vivo.^[150] In mice, channelrhodopsin-2 expression targeted to type II sweet or bitter cells elicited taste-like behaviors upon light stimulation, confirming the specificity of receptor-mediated pathways without chemical stimuli.^[151] These approaches, extended to type III cells, have illuminated presynaptic modulation of taste signals, showing how sour-sensing cells integrate and release neurotransmitters to influence overall gustatory output.^[152] Post-2020 studies have uncovered links between the oral microbiome and taste perception, with dysbiosis altering receptor function and sensitivity.^[153] For instance, shifts in bacterial composition, such as increased acid-producing species, can degrade taste bud integrity or modulate TAS2R signaling, leading to heightened bitterness or reduced sweet detection in conditions like obesity.^[154] Interventions targeting microbiota, including probiotics, have shown potential to restore taste profiles by influencing local pH and metabolite production.^[155] Artificial intelligence has enhanced predictive modeling of taste qualities, particularly bitterness, by leveraging databases like BitterDB to train algorithms on molecular structures.^[156] Tools such as BitterPredict use machine learning to forecast bitterness intensity from chemical features, achieving high accuracy in classifying ligands for TAS2R receptors and aiding drug design to mask off-flavors.^[157] Recent AI frameworks extend this to multi-taste prediction, integrating structural data with receptor binding simulations for broader applications.^[158] In 2023, researchers proposed ammonium chloride as a potential sixth basic taste, evoking a unique unpleasant sensation distinct from bitter or sour.^[159] In May 2025, the structure of the human sweet taste receptor (TAS1R2/TAS1R3) was unveiled using cryo-electron microscopy, providing fundamental insights into how sweet compounds bind and activate the receptor.^[27] Despite these advances, key gaps persist in resolving the full taste code—the precise neural encoding of complex flavor mixtures—and translating findings to personalized nutrition.^[160] Current challenges include integrating multimodal sensory inputs and accounting for individual genetic variability, limiting tailored dietary interventions for conditions like malnutrition or sensory loss.^[161] Emerging efforts in precision nutrition aim to bridge this by combining genomic profiling with taste phenotyping for customized recommendations.^[162]

References

[1]
Physiology, Taste - StatPearls - NCBI Bookshelf - NIH
Jul 30, 2023 · The human body is capable of perceiving five traditional senses: hearing, sight, smell, touch, and taste. Also known as gustation, the sense ...
[2]
Human Biology of Taste - PMC - PubMed Central - NIH
The sense of taste has classically been limited to the 5 basic taste qualities: sweet, salty, sour, bitter, and umami or savory. Advances from the Human Genome ...
[3]
The Organization of the Peripheral Taste System - NCBI - NIH
There are three types of papillae: fungiform (which contain about 25% of the total number of taste buds), circumvallate (which contain 50% of the taste buds), ...
[4]
Anatomy, Head and Neck, Tongue Taste Buds - StatPearls - NCBI
Sep 14, 2025 · Taste buds are located within the fungiform, foliate, and circumvallate papillae of the tongue but are absent from the filiform papillae ...Introduction · Structure and Function · Embryology · Nerves
[5]
Taste Bud Homeostasis in Health, Disease, and Aging - PMC
Nov 28, 2013 · On the mammalian tongue, taste buds reside in fungiform, foliate, and circumvallate papillae. Caution should be exercised when using a novel ...Taste Bud Cell Types And... · Taste Cell Turnover And... · Taste Bud Progenitor And...<|control11|><|separator|>
[6]
Taste Bud - an overview | ScienceDirect Topics
Taste buds appear at the apex of fungiform papillae on the anterior tongue and along trench walls of foliate and circumvallate papillae on the posterior tongue.
[7]
The cell biology of taste - PMC - PubMed Central - NIH
Aug 9, 2010 · Taste buds are aggregates of 50–100 polarized neuroepithelial cells that detect nutrients and other compounds. Combined analyses of gene ...Missing: composition | Show results with:composition
[8]
Progress and renewal in gustation: new insights into taste bud ... - NIH
Nov 1, 2015 · In mice, taste buds comprise 60-100 elongated cells belonging to three morphological types (Types I, II and III), and at least five functional ...Missing: composition | Show results with:composition
[9]
Taste bud homeostasis in health, disease, and aging - PubMed - NIH
Nov 28, 2013 · The mammalian taste bud is an onion-shaped epithelial structure with 50-100 tightly packed cells, including taste receptor cells, supporting ...Missing: composition | Show results with:composition
[10]
Molecular insights into human taste perception and umami tastants
Mar 17, 2022 · The hairlike structures (microvilli or taste hairs) at the taste bud opening (taste pore) mediate the binding of the tastants dissolved in the ...
[11]
The role of saliva in taste and food intake - PMC - NIH
Taste stimuli must dissolve in saliva to reach their receptor targets. This allows the constituents of saliva the opportunity to interact with taste stimuli and ...
[12]
Food-saliva interactions: Mechanisms and implications - ScienceDirect
Saliva plays a role in the variability of eating behavior, perception and preference. ... Changes in viscosity, lubrication and friction, enzymatic breakdown ...
[13]
The scientific exploration of saliva in the post-proteomic era - NIH
Saliva also contains enzymes, including proteases, lipases and glycohydrolases, which initiate partial digestion of food components. Many of these enzyme ...Missing: breakdown | Show results with:breakdown
[14]
Taste Receptors and the Transduction of Taste Signals - NCBI - NIH
The transduction of sweet-tasting compounds involves the activation of G-protein-coupled receptors (GPCRs) on the apical surface of taste cells.
[15]
Article The Receptors for Mammalian Sweet and Umami Taste
We demonstrate that sweet and umami taste are strictly dependent on T1R-receptors, and show that selective elimination of T1R-subunits differentially abolishes ...
[16]
Taste buds: cells, signals and synapses - PMC - PubMed Central
All these taste GPCRs use a common transduction pathway that includes a Gβγ-activated phospholipase C (PLCβ2) and transient receptor potential cation channel ...
[17]
Transient receptor potential family members PKD1L3 and PKD2L1 ...
Aug 15, 2006 · We show that two PKD-like TRP ion channel members, PKD1L3 and PKD2L1, may function as sour taste receptors. Results. Expression of PKD1L3 and ...
[18]
Sour taste: receptors, cells and circuits - ScienceDirect.com
It is worth noting here that PKD2L1 was identified as a putative sour taste receptor by three groups simultaneously [2,8,9]. However, a direct role for PKD2L1 ...
[19]
Does ENaC Work as Sodium Taste Receptor in Humans? - PMC
Apr 24, 2020 · The epithelial sodium channel (ENaC) works as low-salt receptor, mediating acceptance responses to low-medium salt concentrations and driving salt consumption.
[20]
Independent Signal Transduction Mediates Attractive Sodium Taste ...
Jun 3, 2020 · Sodium taste is mediated by cells expressing ENaC and CALHM1/3, where oral Na + entry elicits suprathreshold depolarization for action potentials.
[21]
Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a ...
Dec 28, 2023 · These mutant mice showed a loss of taste perception to quinine dihydrochloride, denatonium benzoate, and cucurbitacin B (CuB).
[22]
Sour Taste Responses in Mice Lacking PKD Channels | PLOS One
These findings suggest that PKD2L1 partly contributes to sour taste responses in mice and that receptors other than PKDs would be involved in sour detection.
[23]
Segregated Expression of ENaC Subunits in Taste Cells
A taste-specific knockout of the α-subunit of the ENaC revealed the relevance of this polypeptide for low-salt transduction, whereas the response to other taste ...<|separator|>
[24]
Why do we like sweet taste: A bitter tale? - PMC - PubMed Central
Sweet taste perception is thought to function for detection of readily available carbohydrates. Sweetness can be a relatively poor indicator of readily ...
[25]
Review An Evolutionary Perspective on Food and Human Taste
May 6, 2013 · Human taste abilities have been shaped, in large part, by the ecological niches our evolutionary ancestors occupied and by the nutrients they sought.
[26]
Mechanisms for Sweetness - PMC - PubMed Central - NIH
All compounds that elicit a sweet taste bind to and activate the T1R2+T1R3 receptor. However, not all sweeteners bind to the same sites on the receptor (Fig. 1) ...
[27]
Human receptors for sweet and umami taste - PNAS
In contrast, human T1R1/T1R3 responds to the umami taste stimulus l-glutamate, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste.<|control11|><|separator|>
[28]
The Functional Role of the T1R Family of Receptors in Sweet Taste ...
T1R2 combines with T1R3 to form a heterodimer that binds with sugars and other sweeteners. T1R3 also combines with T1R1 to form a heterodimer that binds with L- ...
[29]
A taste for sweet – an anthropologist explains the evolutionary ...
Jan 5, 2022 · This message is how you perceive the sweetness in a food you've eaten. Genes encode the instructions for how to make every protein in the body.
[30]
Just noticeable difference in sweetness perception of cola: Small ...
Nov 25, 2022 · By Weber's law (Ekman, 1959; Fechner, 1860), the difference threshold for sugar sweetness should actually get smaller at lower ...
[31]
Relationship between Sucrose Taste Detection Thresholds and ...
Jun 29, 2020 · As shown in Figure 1b, the taste detection threshold of children (10.2 mM) was a more concentrated sucrose solution than either adolescents (8.1 ...Missing: molarity | Show results with:molarity
[32]
Cross-cultural differences in simple taste preferences - Science
Deprivation of visual stimuli increases sensitivity to sweet taste in a Vietnamese Kinh population, Food Quality and Preference, 115, (105129), (2024).https ...
[33]
Mapping sweetness preference across the lifespan for culturally ...
These studies provide preliminary evidence for cross-cultural variability in taste preferences and in the perception of basic tastes. Show abstract.
[34]
The Cellular and Molecular Basis of Sour Taste - PubMed Central
(c) Sour taste transduction is initiated when protons (H+) enter through Otop1 proton-selective ion channels, which serve as sour taste receptors. The ...
[35]
The evolution of sour taste - PMC - NIH
Feb 9, 2022 · While all of these organisms produce short-chain fatty acids when they ferment fruit, yeasts also tend to produce alcohol, and lactic acid ...Missing: spoilage | Show results with:spoilage
[36]
None
### Summary of Sour Acids and Interactions in Beverages
[37]
Interactions of Lemon, Sucrose and Citric Acid in Enhancing Citrus ...
Lemons contain molecules that can arouse both citrus and sour flavors; and lemonade is often made distinctly sweet by adding sugar or artificial sweetener.
[38]
The taste of table salt - PubMed - NIH
Subsequent studies have resolved that this molecule is likely to be an epithelial sodium channel, ENaC. Other Na(+) transduction mechanisms are also present in ...
[39]
Amiloride-sensitive NaCl taste responses are associated with ... - NIH
An epithelial Na+ channel (ENaC) is expressed in taste cells and may be involved in the salt taste transduction. ENaC activity is blocked by amiloride, ...
[40]
High salt recruits aversive taste pathways - PMC - NIH
Aug 28, 2013 · We now show that high-salt recruits the two primary aversive taste pathways by activating the sour and bitter taste-sensing cells.
[41]
Reliability of a Simple Method for Determining Salt Taste Detection ...
Jan 4, 2016 · For session 1, the mean values of the detection and recognition thresholds were 2.8 and 18.6mM, respectively. In session 2, both thresholds were ...
[42]
The Taste Detection Threshold (TDT) Test - PMC - PubMed Central
Apr 21, 2021 · Concentration steps and corresponding molarity of sucrose, sodium chloride (NaCl), and monosodium glutamate (MSG) solutions needed for Taste ...
[43]
Salt Sensation and Regulation - PMC - PubMed Central - NIH
Mar 17, 2021 · Flies can sense five basic tastes—sweet, umami, bitter, salty, and sour—by utilizing chemoreceptors such as gustatory receptors (GRs), ...
[44]
Sodium Intake and Hypertension - PMC - PubMed Central - NIH
High sodium intake and increased BP levels are linked by changes in vascular resistances, but the mechanisms controlling this phenomenon may not be only viewed ...
[45]
Sodium Intake and Hypertension - PubMed
Aug 21, 2019 · The high sodium intake and the increase in blood pressure levels are related to water retention, increase in systemic peripheral resistance, ...
[46]
Dietary Impact of Adding Potassium Chloride to Foods as a Sodium ...
Apr 21, 2016 · Currently, potassium chloride is one of the most commonly used sodium chloride replacers as it has a good ability to convey the perception of a ...
[47]
Bitter taste receptors: Genes, evolution and health - PubMed Central
Each of the major taste qualities in humans (bitter, sweet, umami, sour and salty) is mediated by cells expressing corresponding receptor proteins, with salty ...
[48]
Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors
Dec 18, 2009 · We have challenged 25 human taste 2 receptors (hTAS2Rs) with 104 natural or synthetic bitter chemicals in a heterologous expression system.Results · Molecular Receptive Ranges... · Discussion
[49]
Taste Perception in Humans - Neuroscience - NCBI Bookshelf - NIH
Thus, the threshold concentration for quinine is 0.008 mM, and for strychnine 0.0001 mM. As in olfaction, gustatory sensitivity declines with age.
[50]
Probing the Evolutionary History of Human Bitter Taste Receptor ...
Toxic substances often taste bitter and the perception of this taste is thought to have evolved to protect animals from ingesting potentially harmful compounds ...
[51]
Diet Shapes the Evolution of the Vertebrate Bitter Taste Receptor ...
Nov 7, 2013 · The Tas2r gene number in a species correlates with the fraction of plants in its diet. Because plant tissues contain more toxic compounds than ...
[52]
Structural requirements of bitter taste receptor activation - PNAS
The human bitter taste receptor gene family (hTAS2R) consists of ∼25 ... Aristolochic acid, denatonium benzoate, strychnine, andrographolide ...<|control11|><|separator|>
[53]
Repeated exposure to epigallocatechin gallate solution or water ...
Repeated exposure to epigallocatechin gallate solution or water alters bitterness intensity and salivary protein profile - PMC.
[54]
Bitter Taste Perception in Coffee, Tea, Alcohol Consumption
Nov 15, 2018 · Our results reveal that bitter perception is causally associated with intake of coffee, tea and alcohol, suggesting a role of bitter taste in the development ...Missing: tolerance | Show results with:tolerance
[55]
Science of umami taste: adaptation to gastronomic culture - Flavour
Jan 26, 2015 · Umami is the taste imparted by a number of substances, predominantly the amino acid glutamate and 5′-ribonucleotides such as inosinate and ...
[56]
Who Identified Umami and When? - Ajinomoto Group
Professor Kikunae Ikeda found that glutamate had a distinctive taste, different from sweet, sour, bitter and salty, and he named this taste “umami.Missing: nucleotides | Show results with:nucleotides
[57]
Taste receptors for umami: the case for multiple receptors1 - PMC
Principal among these is the well-known synergy between glutamate and the nucleotides GMP and IMP. ... T1R1+T1R3 must be the only taste receptor for umami. A ...
[58]
Sensing of amino acids by the gut-expressed taste receptor T1R1 ...
The synergistic enhancement of umami taste by IMP or GMP is an exclusive property of T1R1-T1R3 (13, 49, 70, 72). Glu and IMP/GMP bind to adjacent domains on ...
[59]
Umami and MSG | SpringerLink
Sep 13, 2023 · He reported that the taste recognition threshold for monosodium L-glutamate (MSG) was about 1/3000 (1.6 mM), which is lower than that of sucrose ...
[60]
Umami Taste Signaling from the Taste Bud to Cortex - SpringerLink
Sep 13, 2023 · Umami taste is thought to signal the presence of dietary protein. In small quantities, MSG enhances flavor and increases the palatability of ...
[61]
Modulation of Sweet Taste by Umami Compounds via Sweet Taste ...
In this study we investigated umami-sweet taste interactions using umami compounds including monosodium glutamate (MSG), 5'-mononucleotides and glutamyl- ...
[62]
Umami as an 'Alimentary' Taste. A New Perspective on Taste ... - NIH
Jan 16, 2019 · Umami (MSG) has been shown to exhibit partially independent taste perception, as previous studies using multidimensional scaling have found that ...2. Basic Taste Criteria · 3. Umami Taste And Unique... · 4. Umami Taste From An...
[63]
TRPs in Taste and Chemesthesis - PMC - PubMed Central
TRPV1 is a receptor for pungent chemical stimuli such as capsaicin and for several irritants (chemesthesis). It is controversial whether TRPV1 is present in the ...
[64]
Integrating TRPV1 Receptor Function with Capsaicin Psychophysics
Capsaicin is a naturally occurring vanilloid that causes a hot, pungent sensation in the human oral cavity. This trigeminal stimulus activates TRPV1 receptors ...
[65]
A distinct structural mechanism underlies TRPV1 activation by piperine
Jun 15, 2019 · Piperine, the principle pungent compound in black peppers, is known to activate the capsaicin receptor TRPV1 ion channel.
[66]
How Do You Measure the 'Heat' of a Pepper? | NIST
Mar 25, 2025 · A tool, called the Scoville Scale, expresses the level of pungency or heat of a pepper based on the levels of capsaicin in a pepper.
[67]
Rapid determination of capsaicinoids by colorimetric method - PMC
The pungency in chili pepper fruit or food is traditionally measured by the Scoville heat test [12], which gradually dilutes a sample to measure pungency.
[68]
Shifts in Plant Chemical Defenses of Chile Pepper (Capsicum ...
Apr 23, 2018 · Therefore, SMs in chile peppers and other solanaceous plants in Neotropical habitats have evolved as defense mechanisms against microorganisms ...
[69]
A comprehensive review of capsaicin: Biosynthesis, industrial ...
capsaicin is produced and accumulated in the placental tissues of the fruit, which not only enhances the flavor but also the pungency of food [14,15]. This dual ...
[70]
Impact of capsaicin on aroma release and perception from flavoured ...
Oral exposure of capsaicin triggers the trigeminal sensation in the oral cavity to activate TRPV1 (transient receptor potential vanilloid subtype 1) and elicit ...2. Material And Methods · 2.4. Apci-Ms Analysis · 3. Results
[71]
Temporal characteristics of capsaicin desensitization and stimulus ...
It was recently discovered that capsaicin desensitization of the tongue can be temporarily reversed if, after a brief hiatus, capsaicin stimulation is renewed ...
[72]
TRPM8: The Cold and Menthol Receptor - TRP Ion Channel ... - NCBI
It is well known that moderate concentrations of menthol induce a pleasant cool sensation ... Similarly, cold- or menthol-induced TRPM8 currents will adapt ...Missing: oral | Show results with:oral
[73]
Modulation of Thermoreceptor TRPM8 by Cooling Compounds - PMC
TRPM8 is a cold and menthol receptor, and is activated at a temperature threshold of ∼28 °C, with currents increasing in magnitude down to 8 °C, thus spanning ...
[74]
Novel Menthol-Derived Cooling Compounds Activate Primary and ...
The cooling sensation elicited by menthol has been attributed to its action at the transient receptor potential (TRP) channel, TRPM8, which is also activated by ...
[75]
Influence of temperature on taste perception - PubMed
Heat activation of the transient receptor potential channel TRPM5 explains the enhancement of sweet taste perception by warm temperatures.
[76]
Stimulus-Dependent Effects of Temperature on Bitter Taste in Humans
Temperature can affect the perception of bitter taste in at least 2 stimulus-dependent ways: by modulating initial sensitivity and/or bitterness adaptation.
[77]
Modulation of taste processing by temperature - PubMed Central - NIH
There are comparably fewer data on the effects of temperature on the taste qualities of bitter, sour, and umami. ... umami, sweet, and bitter taste transduction.
[78]
(PDF) Influence of temperature on taste perception - ResearchGate
Aug 6, 2025 · ... taste stimuli, the lowest threshold appears at the temperature range of 20 to 30 °C, where it forms a temperature-dependent U-shaped taste curve ...
[79]
The influence of temperature on the threshold values of primary tastes
Daget (1977) reports that the sensitivity is greatest in the temperature range of 20-30°C. ... Meiselmann, H.: 1972, 'Human taste perception', CRC Crit. Rev. Fd.
[80]
TRP (transient receptor potential) ion channel family - Nature
Jul 5, 2023 · TRP channels are responsible for various sensory responses including heat, cold, pain, stress, vision and taste and can be activated by a number of stimuli.
[81]
Localization of TRP Channels in Healthy Oral Mucosa from Human ...
Dec 21, 2022 · Temperature sensation in oral tissues is an important aspect of flavor construction. TRPM8 is a cold and menthol-activated receptor that is ...
[82]
Food temperature affects taste, reveal scientists - Beverage Daily
Dec 19, 2005 · A new study reveals why our taste perception is enhanced as the temperature ... "The clearest example for sweet taste is ice cream. As we all know ...
[83]
Heat as a Factor in the Perception of Taste, Smell, and Oral Sensation
Although other studies have shown that the trends observed for sweetness and bitterness between 20° and 36°C persist at solution temperatures above normal oral ...
[84]
Transient receptor potential channels in dental inflammation and ...
Jan 30, 2025 · Exploring the diverse functions of TRP channels in sensory physiology, including temperature sensation, taste, vision, and olfaction, could ...
[85]
The Role of Salivary Proteins in the Mechanism of Astringency
Apr 19, 2012 · Much of what is known about the mechanism of astringency is based on studies of tannins. Although tannins/polyphenols are known to complex with ...
[86]
Salivary Protein-Tannin Interaction: The Binding behind Astringency
Interactions between salivary proteins and tannins are at the basis of one of the main mechanisms involved in the perception of astringency.
[87]
Sensorial Perception of Astringency: Oral Mechanisms and Current ...
The present review provides a deeper understanding of astringency, a general view of the oral mechanisms involved, and the exciting variety of the latest ...
[88]
Astringency perception in a red wine context – a review - OENO One
Feb 19, 2024 · In a red wine context, astringency is driven by polyphenol concentration, galloylation and degree of polymerisation.
[89]
Herbivores and Plant Tannins - ScienceDirect.com
Tannins can defend leaves against insect herbivores by deterrence and/or toxicity. Contrary to early theories, tannins have no effect on protein digestion ...
[90]
Pungent agents from Szechuan peppers excite sensory neurons by ...
We found that hydroxy-α-sanshool excites neurons through a unique mechanism involving inhibition of pH- and anesthetic-sensitive two-pore potassium channels.Missing: gated | Show results with:gated
[91]
Physiological Basis of Tingling Paresthesia Evokedby Hydroxy-α ...
Mar 24, 2010 · Hydroxy-α-sanshool (sanshool) is a natural plant alkylamide that induces numbing and robust tingling paresthesia in humans (Bryant and Mezine, ...Missing: numbness voltage- gated
[92]
Aroma Constituents and Alkylamides of Red and Green Huajiao ...
The tingling sensation of huajiao is caused mainly by the alkylamide hydroxy-α-sanshool. The tingling compound decomposes easily under hydrolytic conditions or ...<|control11|><|separator|>
[93]
Evidence for Human Orosensory (Taste?) Sensitivity to Free Fatty ...
Mar 14, 2007 · The mean detection threshold for linoleic acid pre-desensitization was 0.034 ± 0.008%, for linoleic acid post-desensitization was 0.032 ± 0.007% ...
[94]
Taste of Fat and Obesity: Different Hypotheses and Our Point of View
In summary, the taste and mouthfeel of fat (its texture and smoothness) identify fat in the diet, and induce a strong hedonic sensation that guides individuals ...Taste Of Fat And Obesity... · 3. High-Fat Diet And Fat... · 4. Taste Of Fat And Obesity<|control11|><|separator|>
[95]
Taste Detection of Maltooligosaccharides with Varying Degrees of ...
Recent research investigated maltodextrins with varying DP and their taste perception (specifically sweetness, starchiness, mouthfeel, and intensity) . This ...
[96]
Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120
Here we show that GPR120 and GPR40 are expressed in the taste buds, mainly in type II and type I cells, respectively. Compared with wild-type mice, male and ...Missing: starchiness maltodextrins
[97]
Involvement of the Calcium-sensing Receptor in Human Taste ...
In this study, we demonstrate that the CaSR is involved in kokumi taste perception in humans and report the discovery of various CaSR agonist peptides, ...
[98]
Kokumi Substances, Enhancers of Basic Tastes, Induce Responses ...
Recently, we reported that calcium-sensing receptor (CaSR) is a receptor for kokumi substances, which enhance the intensities of salty, sweet and umami tastes.
[99]
Kokumi substances, enhancers of basic tastes, induce responses in ...
Recently, we reported that calcium-sensing receptor (CaSR) is a receptor for kokumi substances, which enhance the intensities of salty, sweet and umami tastes.
[100]
Neuroanatomy, Neural Taste Pathway - StatPearls - NCBI Bookshelf
May 1, 2023 · The three nerves associated with taste are the facial nerve (cranial nerve VII), which provides fibers to the anterior two-thirds of the tongue ...Structure and Function · Clinical Significance
[101]
Gustatory System – Introduction to Neuroscience
Therefore, a sour food has high acidity and a high concentration of hydrogen ions, thus a low pH. The exact mechanism for sour taste transduction has yet to be ...
[102]
The Trigeminal (V) and Facial (VII) Cranial Nerves - PubMed Central
Connoisseurs and wine experts intuit that there are interactions between somato-sensation (cranial nerve V) on the tongue and “taste” itself (cranial nerve VII) ...
[103]
Bell's Palsy | Johns Hopkins Medicine
This condition results from damage to the facial nerve (the 7th cranial nerve). ... Loss of the sense of taste on the front 2/3 of the tongue.
[104]
Taste Disorders After Middle Ear Surgery: Chorda Tympani Nerve ...
Flavor alterations that could either be a reduction or an exacerbation of a normal perception involved predominantly salty taste, reported in 47.7% (n = 42), ...
[105]
Neurological Aspects of Taste Disorders - JAMA Network
The facial nerve (CN VII) innervates the anterior two thirds of the tongue, the glossopharyngeal nerve (CN IX) innervates the posterior one third of the tongue ...
[106]
Taste Buds: Development and Evolution - ResearchGate
Aug 7, 2025 · The gustatory system in vertebrates comprises peripheral receptors (taste buds), innervated by three cranial nerves (VII, IX, and X), ...<|control11|><|separator|>
[107]
Gustation - ScienceDirect.com
The gustatory system is the only vertebrate sensory system in which three cranial nerves carry all peripheral gustatory information to the CNS, suggesting the ...
[108]
Taste bud formation depends on taste nerves - eLife
Oct 1, 2019 · The circumvallate papilla receives innervation from visceral sensory neurons in the distal (petrosal) ganglion of the glossopharyngeal nerve, ...
[109]
Central taste anatomy and physiology - PMC
In this chapter, we review the literature on the central processing of taste with a specific focus on the anatomical and physiological responses of single ...Missing: paper | Show results with:paper
[110]
https://doi.org/10.1016/B978-0-444-63855-7.00012-5
[111]
https://doi.org/10.1523/JNEUROSCI.14-09-05437.1994
[112]
The gustatory cortex and multisensory integration - PMC
Abstract. The central gustatory pathways are part of the brain circuits upon which rest the decision to ingest or reject a food. The quality of food stimuli ...Missing: paper | Show results with:paper<|control11|><|separator|>
[113]
https://doi.org/10.1186/1471-2202-8-S3-S5
[114]
The neural processing of taste - PMC - PubMed Central - NIH
Sep 18, 2007 · In this review, we attempt to summarize recent findings in the field that pertain to these issues. Both space and time are variables likely ...Missing: paper | Show results with:paper
[115]
A Population-Based Approach to Study the Impact of PROP ...
Mar 13, 2014 · Thus, the population distribution of non tasters, medium tasters and super tasters is approximately 25%, 50% and 25% respectively [6]. Sequence ...
[116]
Two decades of supertasting: where do we stand? - PMC - NIH
Supertasters experience greater taste intensity, initially measured by PROP bitterness, but now includes elevated responses to all taste qualities, ...
[117]
Effect of Age and Gender on Taste Function as Measured by ... - NIH
Oct 11, 2023 · The overall taste and individual tastant function decreased with age, particularly between subjects aged 20–39 years and those aged ≥60 years.
[118]
New study reveals taste is connected to ethnicity and gender
Apr 8, 2020 · A new study has shown that people of Asian ethnicity experience taste more intensely, and contrary to popular belief it's men who have the sweetest tooth.
[119]
The Association between Consumption of Bitter-taste Vegetables in ...
Jun 9, 2023 · It has been proposed that those individuals identified as super-tasters are more responsive to other taste qualities including fats44 and that ...Missing: less aversion
[120]
Same genetic components underlie different measures of sweet ...
Oct 12, 2025 · Preference for liking of sweet solutions is partially heritable; approximately 50% of the variation in liking of a 20% w/v sucrose solution was ...
[121]
Pseudogenization of a Sweet-Receptor Gene Accounts for Cats ...
Jul 25, 2005 · A functional sweet-taste receptor heteromer cannot form, and thus the cat lacks the receptor likely necessary for detection of sweet stimuli. ...Missing: TMEM | Show results with:TMEM
[122]
Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals ...
It is believed that the receptive ranges of bitter taste receptor repertoires match the profiles of bitter chemicals that the species encounter in their diets.
[123]
The avian taste system - PMC - PubMed Central - NIH
In birds, the family 1 taste receptors (T1R1 and T1R3) mediate the taste of amino acids and sugars, this is, umami and sweet taste in humans, respectively. The ...
[124]
An Update on the Sense of Taste in Chickens: A Better Developed ...
Recent studies show chickens have a well-developed taste system, with 240-360 taste buds, more than previously thought, and a non-lingual system.
[125]
Drosophila Sugar Receptors in Sweet Taste Perception, Olfaction ...
We show that sugar Gr genes are expressed in a combinatorial manner to yield at least eight sets of sweet sensing neurons.
[126]
Evolution of Gustatory Reflex Systems in the Brainstems of Fishes
Fish taste systems evolved with specialized intraoral food-sorting. Despite differences, the essential circuitry is similar, suggesting evolution by ...
[127]
Major taste loss in carnivorous mammals - PMC - NIH
Cats, obligate carnivores, are behaviorally insensitive to sweet-tasting compounds (12, 13). We proposed that this behavioral insensitivity was a consequence of ...Missing: TMEM | Show results with:TMEM
[128]
Developing and regenerating a sense of taste - PMC - NIH
In this review, we highlight new findings in the field of taste development, including how taste buds are patterned and how taste cell fate is regulated.How Are Taste Buds Patterned... · Regulation Of Taste Cell... · Figure 1<|control11|><|separator|>
[129]
Ageusia - StatPearls - NCBI Bookshelf - NIH
Ageusia is a rare condition that is characterized by a complete loss of taste function of the tongue. It requires differentiation from other taste disorders ...Ageusia · Pathophysiology · History And PhysicalMissing: prevalence | Show results with:prevalence
[130]
How to Manage Taste Disorders - PMC - PubMed Central - NIH
Sep 21, 2022 · This study aims to summarize the current state of the art of how taste disorders are clinically best managed.Missing: types | Show results with:types
[131]
Smell and Taste Disorders in Primary Care - AAFP
Disorders of smell and taste are reported by approximately one-fifth of people 40 years and older, and one-third of people 80 years and older.
[132]
Isolated taste disorders in patients referred to a flavor clinic with ...
Feb 16, 2021 · Approximately five percent of the general population are suffering from taste disorders. Usually, subjective loss of taste is caused by smell ...2. Subject And Methods · 3. Results · 4. Discussion<|control11|><|separator|>
[133]
The Acquisition of Likes and Dislikes for Foods - NCBI - NIH
Acceptance or rejection of potential foods by humans can be motivated by sensory properties (like or dislike of the taste and smell), anticipated consequences ...
[134]
Attitudinal effects of mere exposure. - APA PsycNet
Citation. Zajonc, R. B. · Abstract. HYPOTHESIZES THAT MERE REPEATED EXPOSURE OF THE INDIVIDUAL TO A STIMULUS OBJECT ENHANCES HIS ATTITUDE TOWARD IT. · Unique ...
[135]
Habituation or sensitization of brain response to food cues - Frontiers
Feb 16, 2023 · In particular, the amygdala, a region commonly associated with rewards valuation and emotional reactivity, rapidly habituates to repeated ...
[136]
The role of the amygdala in conditioned flavor preference
The data suggest that the amygdala may be critically involved in mediating reward-based conditioned flavor preference.
[137]
TIME INTENSITY PROFILES OF FLAVOR POTENTIATORS (MSG ...
May 11, 2007 · Time to maximum intensity waslong (16–20s), followed by a plateau at maximum intensity, and a persistent aftertaste (50–96s duration).
[138]
Culinary Applications of Umami - IFT.org
May 1, 2005 · Understanding umami and its applications can help food technologists increase consumer acceptance and preference in food selection. Food ...Missing: industry | Show results with:industry
[139]
Accounting for Taste | Science History Institute
Oct 31, 2023 · For 2,300 years, ever since Aristotle, that's how people thought about food, in terms of those four elements—sweet, salty, bitter, and sour. But ...Missing: source | Show results with:source
[140]
Taste - The Biology Of Taste - Buds, People, Example, and Foods
First discovered in the nineteenth century by German scientists Georg Meissner and Rudolf Wagner, taste buds lie on the elevated or ridged surface of the ...
[141]
Who discovered taste buds? - Homework.Study.com
Answer and Explanation: Taste buds where discovered by German anatomists and physiologists Georg Meissner and Rudolf Wagner in the nineteenth century.
[142]
from discovery as a food flavor to role as a basic taste (umami)
In 1908 Kikunae Ikeda identified the unique taste component of konbu (kelp) as the salt of glutamic acid and coined the term umami to describe this taste.
[143]
The psychology of taste and smell status of 1922. - APA PsycNet
Summarizes the destructive and the constructive work of Hans Henning regarding taste and smell perception. Henning's concepts of the smell prism and taste ...
[144]
Duplexity Theory of Taste | Science
Warm and cold stimuli act similarly to the four primary taste stimuli, thus separating the sensations on the tongue into two groups: bitter, warm, sweet; and ...
[145]
Oleogustus: The Unique Taste of Fat - PubMed
Jul 3, 2015 · Shorter chain fatty acids stimulate a sensation similar to sour, but as chain length increases this sensation changes. Fat taste oral signaling, ...Missing: CD36 studies
[146]
Mechanism of fat taste perception: Association with diet and obesity
This review explores the association between taste and obesity by examining the evidence for gustatory mechanisms of fatty acid chemoreception (fat taste)Missing: seminal papers
[147]
Intravital Microscopic Interrogation of Peripheral Taste Sensation
Mar 2, 2015 · We envision an optogenetic approach to control taste cells by introducing light-sensitive proteins into the cells. Then, the imaging setup ...Missing: manipulating | Show results with:manipulating
[148]
Physiological and Behavioral Responses to Optogenetic Stimulation ...
To determine whether Pkd2l1-Cre, ChR2 mice prefer or avoid optogenetic stimulation of type III cells, we devised an experimental paradigm to test taste ...
[149]
Optogenetic Activation of Type III Taste Cells Modulates Taste ...
Jun 25, 2020 · Here, we investigated the effect of optogenetic activation of Type III cells on responses to different taste stimuli, including those mediated ...Missing: manipulating | Show results with:manipulating
[150]
Taste perception and oral microbiota: recent advances and future ...
Recent advances in the sensory field have shown relations between taste perception and the oral microbiota, which could open up for a new pathway to change food ...Missing: post- | Show results with:post-
[151]
The role of the oral microbiome in obesity and metabolic disease
May 27, 2023 · A limited number of studies confirms that changes in taste perception associate with oral microbial composition and further associate with ...The Oral Microbiome · Oral Bacteria And Taste... · Taste Modulation By...Missing: post- | Show results with:post-
[152]
Emerging perspectives: the interplay of taste perception and oral ...
Oct 21, 2024 · This review aims to update the current understanding of how oral microbiota influence taste perception and dietary choices.
[153]
BitterDB: 2024 update on bitter ligands and taste receptors
Nov 13, 2024 · BitterDB has allowed to create a series of bitterness ... M.Y.. Bitter or not? BitterPredict, a tool for predicting taste from chemical structure.
[154]
Bitter or not? BitterPredict, a tool for predicting taste from chemical ...
Sep 21, 2017 · ... predict both bitterness and non-bitterness of a molecule based on its structure. ... BitterDB: a database of bitter compounds. Nucleic Acids ...
[155]
AI-driven prediction of bitterness and sweetness and analysis ... - NIH
May 19, 2025 · The bitterness prediction model classifies the compound as bitter or not, while the sweetness-prediction model classifies it as sweet or not.
[156]
Neuroscience of taste: unlocking the human taste code
Mar 21, 2024 · These results may explain that phylogenic diversity of the animals used in taste research influence the ability to solve the taste code. The ...<|separator|>
[157]
Research gaps and opportunities in precision nutrition: an NIH ...
The workshop concluded that much research will be needed before more precise nutrition recommendations can be achieved.
[158]
Personalized nutrition: perspectives on challenges, opportunities ...
Feb 5, 2025 · Personalized nutrition (PN) delivers tailored dietary guidance by integrating health, lifestyle, and behavioral data to improve individual health outcomes.
[159]
Gut-Brain Axis Research: How Food Affects Your Mind & Body
Anna Hayes combines carbohydrate chemistry and neuroscience to understand the gut-brain axis. Her research on ancient grains and dietary fiber ...Missing: starch taste 2023 2024
[160]
Resistant Starch and Microbiota-Derived Secondary Metabolites
Their role in gut–brain communication, immune modulation, and metabolic regulation suggests potential systemic benefits that extend beyond the colon, especially ...
[161]
Disrupting the Gut–Brain Axis: How Artificial Sweeteners Rewire ...
Oct 21, 2025 · NCSs can mimic “sweetness” taste by activating T1R2/T1R3 receptors, but they do not deliver calories. This decouples the sensory signal ( ...