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Retrospective cohort study

A retrospective cohort study, also known as a historic cohort study, is an observational research design in which investigators analyze existing historical records to identify groups of individuals who share similar characteristics but differ by a specific exposure (such as occupational exposure in factory workers), then compare these groups for the incidence of a particular outcome (such as lung disease) that has already occurred.^[1] In this approach, the cohort is assembled after the outcomes have been observed, using preexisting data to trace exposures backward in time while following the group forward to assess associations.^[2]^[3] Unlike prospective cohort studies, which enroll participants and follow them forward in real-time to observe outcomes, retrospective designs leverage past records—such as medical charts, registries, or administrative databases—to reconstruct exposure histories and outcomes, allowing researchers to identify exposed and unexposed individuals without regard to the outcome at the time of data collection.^[2] This method establishes temporality (exposure preceding outcome) and directly measures incidence rates, making it valuable in epidemiology for investigating rare exposures or long-latency diseases where prospective follow-up would be impractical.^[3] Common data sources include electronic health records or cohort databases, enabling efficient analysis of large populations over extended periods.^[4]

Fundamentals

Definition

A retrospective cohort study is an observational epidemiological design that utilizes existing historical data to identify a cohort of individuals based on their exposure status at a point in time in the past, then examines the association between those past exposures and subsequent health outcomes.^[5]^[6] In this approach, both the exposure and outcomes have already occurred by the time the study is initiated, allowing researchers to reconstruct events from records rather than prospectively following participants.^[5]^[2] Key terminology includes the cohort, a defined group of individuals assembled and "followed" over time through records to observe outcomes; the exposure, the risk factor or intervention of interest that occurred in the past; and the outcome, the health event or disease status measured in relation to the exposure.^[7]^[4] The core principles revolve around leveraging preexisting data sources, such as medical records or registries, to retrospectively trace exposure and outcome timelines, with the cohort stratified by exposure status (e.g., exposed versus unexposed groups) at a historical index date.^[3]^[8] In terms of timeline, the exposure happens in the past, the cohort is assembled from historical records at the present time, and outcomes are assessed by looking either forward from the exposure point (using follow-up data) or backward if already recorded, providing a snapshot of associations without real-time intervention.^[2]^[9] This distinguishes it from prospective designs by relying entirely on archived information to minimize recall bias and enable efficient analysis of past events.^[4]^[10]

Historical Development

Retrospective cohort studies emerged as a distinct epidemiological method in the early 20th century, building on precursors from 19th-century occupational epidemiology that systematically examined health outcomes among exposed workers, such as factory operatives in industrial settings.^[11] These early investigations, often descriptive, laid the groundwork by linking occupational exposures to diseases like respiratory conditions in cotton mills, though formal cohort designs using historical data developed later to address limitations of prospective studies, including time and cost constraints.^[11] The term "cohort study" itself was coined by Wade Hampton Frost in 1935, initially for prospective designs, but retrospective applications quickly followed.^[12] A key milestone occurred in 1933 when Frost conducted one of the first explicit retrospective cohort analyses, studying tuberculosis transmission in Tennessee families by reconstructing past exposure and outcome data from records to calculate person-years at risk.^[13] The method gained prominence in the 1950s amid post-World War II epidemiological efforts, notably through studies on radiation exposure; the Life Span Study, initiated in 1950 by the Atomic Bomb Casualty Commission (later the Radiation Effects Research Foundation), assembled a partially retrospective cohort of about 120,000 Hiroshima and Nagasaki survivors using 1950 census data to assess long-term health effects.^[14] Influential figures like Richard Doll advanced the approach with his 1952 retrospective cohort study of British gas workers, analyzing company records from 1939–1948 to link occupational exposures to lung cancer mortality, providing early evidence of smoking's role.^[13] Doll further contributed in 1957 with a study of over 14,000 ankylosing spondylitis patients treated with X-ray therapy, retrospectively evaluating leukemia risks from irradiation records.^[13] The 1960s marked expansion through medical record linkage, enabling larger-scale analyses, as seen in Doll's 1958 retrospective cohort of nickel refinery workers (1929–1938 data) that quantified respiratory cancer risks, as discussed by Bradford Hill in 1966.^[13] By the 1970s, methodological refinements, including nested case-control designs within cohorts (e.g., Doll's 1972 gas workers follow-up), standardized retrospective approaches for efficiency in analyzing rare outcomes.^[13] In the modern era, from the 1990s onward, integration with electronic health records revolutionized retrospective cohorts, facilitating massive analyses of preexisting data for outcomes like cancer and cardiovascular disease; for instance, studies using digitized registries from the 1970s–1980s, as in Thériault et al.'s 1994 cohort of aluminum workers, demonstrated improved linkage and biomarker incorporation.^[13]^[15] This evolution has enabled high-impact, population-level research while maintaining the core principle of using historical data to infer causality.^[16]

Methodology

Design Process

The design process for a retrospective cohort study involves a systematic approach to planning and assembly, leveraging existing historical data to investigate associations between exposures and outcomes. This process starts with clearly defining the research question and hypothesis, which includes specifying the exposure variable (such as a risk factor like smoking or occupational hazard) and the outcome variable (such as disease incidence or mortality). Researchers must ensure that the question is feasible with available past records and aligns with the study's objectives, often drawing on preliminary literature to refine these elements.^[8] Following hypothesis formulation, the next step is identifying and selecting the cohort from historical sources, such as electronic medical records, registries, or administrative databases. The cohort comprises individuals who share a common characteristic relevant to the exposure at a defined point in the past, with careful attention to ensuring representativeness of the target population and minimizing selection bias through inclusion criteria that avoid over- or under-sampling specific subgroups. For instance, eligibility might be based on diagnosis codes or demographic filters applied uniformly across the data source to promote comparability. This selection phase requires validation of data quality and completeness to support reliable inference.^[8] Once the cohort is assembled, researchers classify exposure status retrospectively by reviewing records to categorize participants into groups, such as exposed versus unexposed, based on documented evidence of the exposure's timing, duration, and intensity prior to the outcome period. This classification must be standardized using predefined criteria to reduce misclassification bias, often involving abstraction tools or algorithms for consistency across large datasets.^[8] Subsequently, the follow-up period is determined by establishing the time frame from exposure assessment to outcome evaluation, using the historical timeline inherent in the data to simulate longitudinal tracking without prospective collection. Outcomes are then ascertained retrospectively through the same records, confirming events like disease onset or death via diagnostic codes, laboratory results, or vital statistics, while accounting for censoring due to loss to follow-up in the past data. A critical pitfall in this design is verifying the temporal sequence, ensuring that exposure clearly precedes the outcome to support causal inference and avoid reverse causation artifacts from incomplete chronologies.^[8] Ethical considerations are integral to the design, particularly given the reliance on secondary data; studies must utilize de-identified or anonymized records to protect participant privacy and confidentiality, often through irreversible removal of personal identifiers or secure coding systems. Institutional Review Board (IRB) approval is required for secondary data analysis, even without direct patient contact, to evaluate risks, benefits, and data handling protocols, with waivers of informed consent permissible when re-contacting participants is infeasible (e.g., due to death or cohort size) and opt-out mechanisms are provided. These measures align with principles of respect for persons, beneficence, and justice, ensuring the research does not unduly harm vulnerable populations represented in historical data.^[17]

Data Collection and Analysis

In retrospective cohort studies, data collection relies on secondary sources that capture historical information on exposures and outcomes, including electronic health records (EHRs), administrative databases, disease registries.^[18] EHRs supply detailed clinical details such as patient demographics, diagnoses, procedures, and longitudinal follow-up, enabling large-scale analyses without prospective enrollment.^[18] Administrative databases, often derived from billing and claims systems, provide population-level data on healthcare utilization and costs, facilitating studies of rare events across broad cohorts.^[18] Registries, such as cancer or birth defect registries, offer specialized, high-quality data on specific conditions with standardized reporting protocols.^[18] Data extraction from these sources employs record linkage techniques to merge disparate datasets accurately. Probabilistic matching, grounded in the Fellegi-Sunter algorithm, evaluates potential record pairs by calculating linkage weights based on agreement probabilities (m-probability for true matches and u-probability for random matches) across identifying fields like name, date of birth, and address.^[19] Weights are derived as \log_2(m/u) for agreements and \log_2((1-m)/(1-u)) for disagreements, with thresholds set to achieve high positive predictive value (e.g., >95%), often using blocking variables like geographic region to reduce computational demands.^[19] This approach minimizes false positives and negatives, essential for unbiased cohort assembly. Handling missing data is integral, with multiple imputation generating several plausible datasets from observed patterns to account for missing at random (MAR) mechanisms, followed by pooled analyses.^[20] Sensitivity analyses further evaluate robustness by varying imputation assumptions or excluding incomplete cases, particularly when data are missing not at random (MNAR).^[21]^[22] Analytical methods focus on quantifying exposure-outcome associations through incidence measures and effect estimates. Incidence rates are calculated as the number of new outcome events divided by the person-time at risk in exposed (I_e) and unexposed (I_u) groups, providing a time-adjusted metric for event occurrence.^[23] The relative risk (RR) is then determined as the ratio of these rates:

RR = \frac{I_e}{I_u}

with 95% confidence intervals estimated via approximations like Koopman’s likelihood-based method to assess precision.^[24] For time-to-event outcomes, the Cox proportional hazards model is applied, modeling the hazard function as h(t|X) = h_0(t) \exp(\beta X), where h_0(t) is the baseline hazard and \beta X incorporates covariates, yielding hazard ratios under the assumption of proportional hazards over time.^[25] Confounder adjustments ensure valid effect estimates by accounting for variables like age, sex, or comorbidities that may distort associations. Stratification partitions the cohort into homogeneous subgroups by confounder levels, computing stratum-specific RRs or hazard ratios and pooling them using the Mantel-Haenszel estimator to derive an adjusted summary measure.^[26] Multivariable regression extends this by simultaneously adjusting for multiple confounders in a single model, such as logistic regression for binary outcomes or Cox models for survival data, where covariates are included to estimate adjusted odds or hazard ratios while assuming linearity and no residual confounding.^[26] Quality assurance emphasizes validation and bias mitigation tailored to historical data limitations. Data accuracy is verified through audits, cross-referencing with primary records, and application of validated diagnostic algorithms to reduce misclassification from inconsistent coding.^[22] Recording biases, arising from incomplete or erroneous historical entries, are addressed by standardizing extraction protocols and using quantitative bias analysis to quantify and correct misclassification impacts.^[27] Recall biases, relevant for survey-derived exposures, are minimized by prioritizing objective administrative or registry data over self-reported information.^[27] Overall, sensitivity analyses and propensity score methods further enhance reliability by testing assumptions and balancing cohorts on observed confounders.^[22]

Strengths and Limitations

Advantages

Retrospective cohort studies offer significant cost and time efficiencies compared to prospective designs, as they utilize pre-existing data rather than requiring new collection efforts, allowing researchers to complete analyses more rapidly and at lower expense.^[28] For instance, by drawing from historical records, these studies avoid the prolonged follow-up periods inherent in prospective cohorts, enabling quicker generation of results without the need for ongoing resource allocation.^[29] This efficiency is particularly pronounced when accessing large administrative or clinical databases, which provide extensive sample sizes and enhance statistical power for detecting associations.^[30] These studies are especially feasible for investigating rare exposures or conditions with long latency periods, such as occupational carcinogens like asbestos, where prospective follow-up would be impractical due to the decades required to observe outcomes.^[31] By leveraging existing datasets that span extended time frames, retrospective cohorts can capture exposure-outcome relationships that occurred in the past, making them suitable for events that are infrequent or have delayed effects.^[4] A key benefit is the capacity to examine multiple outcomes arising from a single exposure using the same dataset, without necessitating additional data gathering, which streamlines research into diverse health effects.^[32] Furthermore, their reliance on routine clinical or population records ensures high real-world applicability, reflecting genuine exposures and outcomes in diverse populations rather than controlled settings.^[29] This approach facilitates insights into practical healthcare scenarios, such as treatment patterns in large registries.^[33]

Disadvantages

Retrospective cohort studies are susceptible to selection bias, as the reliance on existing historical records can result in incomplete or non-representative cohorts, where certain groups may be systematically excluded due to poor documentation or access to data.^[27] For instance, missing data from nonresponders or inadequate registration can skew the composition of the study population, leading to over- or underestimation of associations between exposures and outcomes.^[34] This bias is particularly pronounced when the available records do not capture the full target population, compromising the internal validity of the findings.^[35] Information bias represents another key limitation, stemming from inaccuracies or inconsistencies in past data recording that can misclassify exposures or outcomes.^[27] In retrospective designs, medical charts or databases originally created for clinical purposes rather than research often contain errors, omissions, or variations in measurement standards over time, which may introduce non-differential misclassification and bias results toward the null hypothesis.^[34] Such data quality issues, briefly referencing challenges in collection as noted in methodological overviews, further exacerbate the potential for systematic errors in exposure assessment.^[8] Confounding poses significant challenges in retrospective cohort studies, as historical data may lack comprehensive information on potential confounders, making it difficult to identify and adjust for unmeasured variables that influence both exposure and outcome.^[35] Factors such as socioeconomic status, comorbidities, or environmental influences from past contexts are often incompletely recorded, leading to residual confounding that distorts the observed associations.^[36] This limitation is inherent to the use of pre-existing records, where investigators cannot prospectively collect data on all relevant covariates.^[27] The establishment of temporality, a cornerstone of causal inference, is hindered in retrospective cohort studies by imprecise timing of exposure and outcome data in historical records, complicating the confirmation that exposures preceded outcomes.^[37] While the design inherently supports temporality through backward-looking analysis, ambiguities in record-keeping—such as approximate dates or retrospective recall—can weaken the ability to precisely sequence events, potentially undermining causal claims.^[38] Finally, generalizability is limited in retrospective cohort studies due to the dependence on available historical data, which may not reflect diverse populations or current conditions, restricting the applicability of results beyond the specific cohort or era studied.^[27] Selection from narrow databases or institutional records often results in cohorts that underrepresent marginalized groups or vary in demographic composition, thereby affecting external validity.^[34]

Comparisons with Other Designs

Prospective Cohort Studies

A prospective cohort study is an observational research design in which a group of individuals (the cohort) is identified and assembled in the present based on exposure status to a potential risk factor, and then followed forward over time to monitor the occurrence of specified health outcomes.^[9] This approach allows researchers to collect data in real-time as events unfold, ensuring that exposure precedes the outcome and facilitating the establishment of temporality in causal inferences.^[4] Unlike retrospective designs, prospective studies enable standardized protocols for data gathering from the outset, often involving baseline assessments followed by periodic follow-ups.^[39] The primary differences between prospective and retrospective cohort studies lie in the timing of data collection, resource demands, and susceptibility to biases. In prospective studies, data on exposures and outcomes are gathered moving forward from the study's initiation, contrasting with retrospective studies that rely on historical records of past exposures and outcomes.^[8] Prospective designs are generally more resource-intensive and time-consuming due to the need for ongoing participant monitoring, whereas retrospective studies are quicker and less costly since they utilize existing data sources like medical records or registries.^[16] Regarding biases, prospective cohorts are prone to loss-to-follow-up, where participants may drop out, potentially skewing results if attrition is related to the exposure or outcome; in contrast, retrospective cohorts face higher risks of information bias from incomplete or inaccurate historical data and selection bias in cohort assembly from past records.^[27] Additionally, prospective studies offer greater control over confounding variables through predefined measurement protocols, while retrospective ones may introduce confounding by indication if data on comorbidities were not uniformly recorded.^[40] Retrospective cohort studies are often preferred over prospective ones when investigating rare exposures, as historical data allow for rapid assembly of large cohorts without waiting for events to occur, or when ethical constraints prevent forward observation of potentially harmful exposures.^[3] For instance, studying the long-term effects of occupational exposures from decades ago would be impractical prospectively due to the extended follow-up required, making retrospective analysis more feasible.^[35] Relative to retrospective designs, prospective cohort studies provide superior data quality through prospective ascertainment, minimizing misclassification of exposures and outcomes, and stronger confirmation of temporality since the sequence of events is observed directly rather than inferred from records.^[39] This real-time approach also reduces recall bias, as participants report current or recent information rather than distant past events, enhancing the reliability of findings for establishing causality.^[8]

Case-Control Studies

A case-control study is an observational research design that begins by identifying individuals with a specific outcome of interest (cases) and a comparable group without that outcome (controls), then retrospectively examines their prior exposures to potential risk factors to assess associations.^[9] This approach contrasts with the retrospective cohort study, where participants are grouped based on their exposure status at some point in the past, and outcomes are then tracked forward in historical data to determine incidence rates.^[4] In structural terms, the retrospective cohort design follows the temporal sequence from exposure to outcome, enabling direct calculation of relative risks, whereas case-control studies reverse this direction by starting from the outcome and probing exposures, which inherently limits them to estimating odds ratios as proxies for relative risk.^[4] Efficiency differences arise from these structural variations, particularly in handling rarity and multiplicity. Retrospective cohort studies are particularly advantageous when investigating multiple potential outcomes stemming from a single exposure, as the same cohort can yield incidence data across various endpoints without additional recruitment.^[9] Conversely, case-control studies excel in efficiency for rare outcomes or diseases with long latency periods, requiring smaller sample sizes—often just hundreds of participants—compared to the thousands typically needed in retrospective cohorts to achieve adequate power for infrequent events.^[4] This makes case-control designs quicker and less resource-intensive, ideal for preliminary hypothesis generation in scenarios where full cohort assembly would be prohibitive.30457-8/fulltext) Regarding biases and statistical power, retrospective cohort studies generally mitigate recall bias in exposure assessment by relying on existing records or baseline data collected prospectively relative to the outcome period, though they demand larger samples to detect associations, increasing vulnerability to loss-to-follow-up if data is incomplete.^[4] Case-control studies, however, are more susceptible to differential recall bias, as both cases and controls must retrospectively report or verify past exposures, potentially leading to over-reporting among cases; additionally, their power relies on odds ratios approximating relative risk, an assumption that holds well only for rare outcomes but introduces approximation errors otherwise.^[9] Both designs face selection bias risks, but case-control studies amplify this through control group matching, necessitating careful population representation to avoid confounding.^[41] Selection criteria for these designs hinge on research goals and logistical constraints. Retrospective cohort studies are preferred when accurate incidence estimation and direct relative risk calculation are essential, such as in evaluating common exposures with varied outcomes using archived data.^[4] In contrast, case-control studies are chosen for rapid hypothesis testing in the context of rare diseases, where their efficiency allows timely insights despite analytical limitations, often serving as a foundational step before larger confirmatory cohorts.^[9]

Applications and Examples

Common Uses

Retrospective cohort studies are widely employed in epidemiology to investigate associations between environmental or occupational exposures and disease outcomes, particularly where historical exposure data is available from records or registries. For instance, they have been instrumental in linking asbestos exposure to the development of mesothelioma, allowing researchers to analyze past occupational histories and subsequent cancer incidences in exposed worker cohorts.^[42]^[43] In pharmacoepidemiology, these studies are routinely used to assess drug safety and effectiveness by leveraging large administrative claims databases that capture prescription histories, healthcare utilization, and outcomes. This approach enables efficient evaluation of rare adverse events or long-term effects in real-world populations without the need for prospective follow-up.^[44]^[45] Health services research frequently applies retrospective cohort designs to evaluate treatment outcomes using electronic health records or hospital databases, facilitating comparisons of interventions across diverse patient groups. Such analyses help identify variations in care delivery and their impact on recovery rates or complications.^[22] For infectious disease surveillance, retrospective cohort studies trace outbreaks by examining historical registries of cases, exposures, and contacts, which supports reconstruction of transmission dynamics and identification of risk factors. This method is particularly valuable in post-outbreak assessments to inform future prevention strategies.^[9] In chronic disease studies, retrospective cohorts drawn from population-based registries link lifestyle factors, such as smoking, diet, and physical activity, to long-term outcomes like mortality or disease progression in large-scale analyses. These studies capitalize on the accessibility of extensive historical data to quantify cumulative risks over decades.^[46] The ability to access large samples retrospectively enhances the statistical power for detecting subtle associations in these applications.^[22]

Notable Examples

A notable example is the Life Span Study (LSS) of atomic bomb survivors in Hiroshima and Nagasaki, which exemplifies retrospective cohort components by drawing on 1945 exposure records to investigate long-term health effects in a cohort of approximately 120,000 individuals.^[47] Researchers retrospectively categorized radiation doses from historical dosimetry data and linked them to cancer incidence and mortality followed since 1950, demonstrating a linear increase in solid cancer risk with doses above 0.1 Gy.^[48] Another classic retrospective cohort study is the analysis by Selikoff et al. in the 1960s of U.S. asbestos insulation workers, using historical employment and medical records from union files to compare lung cancer and mesothelioma incidence in exposed versus unexposed groups, revealing strong associations with asbestos exposure duration.^[42] These examples highlight the retrospective cohort design's strength in establishing long-term causality by leveraging existing records for exposure assessment, though they also underscore challenges such as incomplete data from wartime-era documentation, which required imputation methods to address missing exposure details in the LSS.^[47] Overall, such studies have profoundly influenced public health policy, including international radiation protection standards shaped by LSS evidence and asbestos regulations following occupational exposure findings.

References

[1]
Definition of retrospective cohort study - National Cancer Institute
A research study in which the medical records of groups of individuals who are alike in many ways but differ by a certain characteristic.Missing: epidemiology | Show results with:epidemiology
[2]
Historical (retrospective) cohort studies and other epidemiologic ...
Sep 5, 2018 · In a retrospective (historical) cohort, investigators use preexisting data to identify exposed and unexposed individuals in the past, without regard to outcome ...
[3]
[PDF] Cohort Studies - UNC Gillings School of Public Health
Prospective studies follow a cohort into the future for a health outcome, while retrospective studies trace the cohort back in time for exposure information ...
[4]
Observational Studies: Cohort and Case-Control Studies - PMC - NIH
The primary disadvantage of this study design is the limited control the investigator has over data collection. The existing data may be incomplete, inaccurate, ...
[5]
Principles of Epidemiology | Lesson 1 - Section 7 - CDC Archive
An alternative type of cohort study is a retrospective cohort study. In this type of study both the exposure and the outcomes have already occurred. Just as in ...
[6]
Methodology Series Module 1: Cohort Studies - PMC - NIH
Retrospective cohort study In this type of cohort study, the data are collected from records. Thus, the outcomes have occurred in the past.
[7]
6 Cohort Studies – STAT 507 | Epidemiological Research Methods
In general, the descriptor, 'prospective' or 'retrospective', indicates when the cohort is identified relative to the initiation of the study. Sometimes ...
[8]
Overview: Cohort Study Designs - PMC - NIH
Retrospective Cohort Design Retrospective cohort studies are also called historical cohort studies. The term historical is fitting since data analysis occurs ...
[9]
Designing and Conducting Analytic Studies in the Field - CDC
Aug 8, 2024 · Table 7.1. Benefits and drawbacks of three observational study types commonly used in field investigations. Feature, Retrospective cohort study ...Missing: disadvantages | Show results with:disadvantages
[10]
[PDF] Overview Cohort Studies Handout
In the retrospective cohort study (also known as a historical cohort study), the exposure and disease has already occurred. This study differs from a case ...
[11]
The development of cohort studies in epidemiology: A review
An historical outline of the evolution of cohort (or incidence) studies spans well over 100 years, from the work of Farr and Snow in the 1850s.
[12]
history of the method. I. Prospective cohort studies - PubMed
The term "cohort study" was introduced by Frost in 1935 to describe a study that compared the disease experience of people born at different periods.
[13]
History of the method II. Retrospective cohort studies
Cohort studies in the original sense of the generation studies introduced by Andvord in 193035 helped our understanding of the spread of tuberculosis and the ...
[14]
Japanese Legacy Cohorts: The Life Span Study Atomic Bomb ...
Mar 17, 2018 · All cohort members have been followed since 1950. As the cohort was constructed in the late 1950s, the LSS is partially a retrospective cohort.
[15]
Twenty-Five Years of Evolution and Hurdles in Electronic Health ...
Jan 9, 2025 · This study aimed to summarize the evolution of secondary use of EHRs and their interoperability in medical research over the past 25 years.
[16]
Retrospective Cohort Study - an overview | ScienceDirect Topics
A retrospective cohort study is defined as a research method where investigators assemble a cohort by reviewing past records to identify exposures and ...
[17]
https://doi.org/10.4414/smw.2010.13041
[18]
Understanding data requirements of retrospective studies - PMC - NIH
We analyzed the data requirements of over 100 retrospective studies by mapping the selection criteria and study variables to data elements of two standard data ...
[19]
An Overview of Record Linkage Methods - NCBI - NIH
In this chapter, we guide the reader through an overview of data linkage methods and discuss the strengths and weaknesses of various linkage strategies.
[20]
Proper Use of Multiple Imputation and Dealing with Missing ...
Statistical considerations and importance of sensitivity analysis were explained. Various imputation methods were applied to a retrospective cohort.
[21]
Statistical primer: how to deal with missing data in scientific research?
May 10, 2018 · Single imputation may, however, be used to perform sensitivity analyses for missing covariate information or primary outcome data to ensure that ...Abstract · INTRODUCTION · METHODOLOGY · DISCUSSION
[22]
Improving the Quality and Design of Retrospective Clinical Outcome ...
In this paper we will highlight the benefits of large retrospective studies from secondary sources such as EHRs, examine retrospective cohort and case-control ...
[23]
[PDF] Risk and Rate Measures in Cohort Studies
Cohort studies are longitudinal studies where an exposed and an unexposed group (or less exposed group) are followed forward in time to find the incidence ...
[24]
Relative Risk, Risk Difference, Attributable Risk - StatsDirect
This function calculates relative risk, risk difference and population attributable risk difference with confidence intervals.
[25]
Statistical Methods for Cohort Studies of CKD: Survival Analysis in ...
Feb 27, 2017 · At each point in time, the Cox proportional hazards model uses the data from all cases that are in the risk set at that particular time.
[26]
Control of confounding in the analysis phase – an overview for ... - NIH
Mar 31, 2017 · Confounding can be controlled in the analysis phase using stratification, standardization, multivariable regression, propensity score (PS), and ...
[27]
Limitations and Biases in Cohort Studies - IntechOpen
This chapter highlights the types of biases, their origin, their effects on the validity of the study and ways to avoid or minimize them.
[28]
Prospective cohort versus retrospective cohort studies to estimate ...
Retrospective cohort studies like this are very efficient because they take much less time and cost much less than prospective cohort studies.
[29]
Retrospective cohort studies: advantages and disadvantages
Jan 24, 2014 · However, an advantage for both study designs is that exposure to risk factors is recorded before the occurrence of the outcome. This is ...
[30]
5.1. Types of Observational Studies: Cohort Studies
Retrospective cohort studies: Points to consider. Advantages. useful for tracking the progress of a disease with a long latency period from study start ...
[31]
What is a Cohort Study & Why are they Important? CASP
Retrospective Cohort Study: In this type of cohort study, the investigator uses existing data to identify the group of people exposed to a risk factor and a ...<|control11|><|separator|>
[32]
Retrospective studies - utility and caveats - PubMed
Retrospective studies however have several limitations owing to their design. Since they depend on review of charts that were originally not designed to ...
[33]
Cohort studies investigating the effects of exposures - NIH
Jan 13, 2022 · Confounding occurs when the exposure of interest is associated with another factor that also influences the outcome of interest. Investigators ...
[34]
[PDF] Retrospective Chart Reviews - Marshall University
In a retrospective study, data collected on dependent and independent variables from the medical record must be put into a database. Designing a data ...
[35]
What Is a Retrospective Cohort Study? | Definition & Examples
Feb 10, 2023 · A retrospective cohort study is a type of observational study that focuses on individuals who have an exposure to a disease or risk factor in common.When to use a retrospective... · Examples of retrospective... · Advantages and...
[36]
Cohort Studies - CHEST Journal
In contrast, a retrospective study is conceived after subjects have already developed the outcome. The investigators jump back in time to identify a cohort of ...
[37]
Cohort studies: prospective versus retrospective - PubMed
Prospective and retrospective cohort studies have higher accuracy and higher efficiency as their respective main advantages.
[38]
A Case-control or a retrospective cohort study? Comment on the ...
Apr 13, 2016 · Case-control studies have a different design, where researchers select cases and controls based on the presence or absence of the outcome, ...
[39]
Impact of asbestos on public health: a retrospective study on a ... - NIH
The goal of this study is to understand more about the role of asbestos in causing human diseases, first of all mesothelioma, by investigating a large ...
[40]
Asbestos Exposure and Malignant Pleural Mesothelioma
Jan 10, 2023 · This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM.Results · Discussion · Summary Of Evidence<|separator|>
[41]
The reporting of studies conducted using observational routinely ...
Nov 14, 2018 · The RECORD-PE statement is intended for use only in reporting on pharmacoepidemiology studies conducted with routinely collected health data, ...
[42]
Pharmacoepidemiology: An Overview - MDPI
Nov 10, 2023 · Cohort studies: Prospective and retrospective cohort studies follow a defined population over time who is exposed to a drug and compare ...
[43]
Smoking, drinking, diet and physical activity—modifiable lifestyle risk ...
Apr 26, 2019 · This study examined the incidence of a person's first diagnosis of a selected chronic disease, and the relationships between modifiable lifestyle risk factors ...Smoking, Drinking, Diet And... · Chronic Disease Outcomes · Results
[44]
Mortality in relation to smoking: the British Doctors Study - PMC - NIH
It can be considered the first strong statistical proof of the correlation between smoking habit and many serious diseases, including lung cancer.Missing: retrospective | Show results with:retrospective
[45]
British Doctors Study - CTSU
In October 1951, Sir Richard Doll and Sir Austin Bradford Hill sent a questionnaire on smoking habits to all registered British doctors. Of the 59600 ...
[46]
The Life Span Study Atomic Bomb Survivor Cohort and ... - PubMed
Apr 5, 2018 · The Life Span Study, the cohort of survivors, consists of about 120,000 subjects and has been followed since 1950. Cohorts of in utero survivors ...
[47]
Life Span Study (LSS) - RERF Research
Its major objective is to investigate the long-term effects of A-bomb radiation on causes of death and incidence of cancer.