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Stellate cell

Stellate cells are neurons in the central nervous system (CNS) named for their star-like shape, formed by multiple dendritic processes radiating from a central cell body. They are primarily found in the cerebral cortex and cerebellum, serving as interneurons that contribute to sensory processing, motor coordination, and neural circuit refinement.^[1] In the cerebral cortex, stellate cells are abundant in layer IV of sensory areas, where spiny stellate cells act as excitatory relay neurons, receiving thalamic afferents and projecting to upper layers to facilitate sensory integration. In the cerebellum, stellate cells function as inhibitory GABAergic interneurons in the molecular layer, providing feedforward and feedback inhibition to Purkinje cells to modulate motor output.^[1]^[2] These cells originate from neural progenitor cells during embryonic development, with postnatal maturation refining their dendritic arborization and synaptic connectivity. Dysfunctions in stellate cells are implicated in neurological disorders such as epilepsy, ataxia, and cortical dysplasias, highlighting their role in synaptic integration and neurovascular coupling. Research advances focus on their contributions to brain plasticity and potential therapeutic interventions.^[3]

Morphology

General Morphology

Stellate cells are mesenchymal cells characterized by their star-shaped morphology, featuring a central cell body from which multiple long, thin cytoplasmic processes extend to interact with neighboring parenchymal cells and the extracellular matrix.^[4] In their quiescent state, these cells contain numerous lipid droplets rich in vitamin A (retinyl esters), which occupy up to 20-30% of the cell volume and are visible under light or electron microscopy. The cell body typically measures 10-20 μm in diameter, with processes extending up to 50-100 μm in length, allowing broad coverage of the perisinusoidal or periacinar spaces.^[4] These processes often bear microprojections that facilitate chemosensory functions and paracrine signaling. Quiescent stellate cells exhibit a reduced endoplasmic reticulum and Golgi apparatus, reflecting their primary role in lipid storage rather than protein synthesis. Upon activation in response to injury, they undergo transdifferentiation into myofibroblast-like cells, marked by the loss of lipid droplets, nuclear enlargement, and proliferation of rough endoplasmic reticulum and contractile microfilaments. Activated cells adopt a more spindle-shaped or flattened morphology, with the cell body expanding to 20-50 μm, and express α-smooth muscle actin (α-SMA) for enhanced contractility.^[5] This transformation is visualized using techniques such as immunohistochemistry for α-SMA and desmin, or transmission electron microscopy to observe lipid droplet dynamics and cytoskeletal changes. Historically, their morphology was first described using gold chloride methods in the 19th century, evolving to modern imaging like confocal microscopy for three-dimensional reconstruction.^[4]

Type-Specific Variations

Hepatic stellate cells (HSCs), located in the space of Disse between hepatocytes and sinusoidal endothelial cells, display quiescent morphology with 10-20 lipid droplets per cell (each 1-5 μm in diameter) and long processes that envelop sinusoids, comprising about 5-10% of liver cells. Upon activation, HSCs lose most droplets (fewer than 5 remaining) and develop thickened processes, contributing to fibrotic scarring.^[4] Pancreatic stellate cells (PSCs), found in periacinar, periductal, and perivascular regions, share similar quiescent features but constitute 4-7% of pancreatic cells, with lipid droplets numbering 5-15 per cell and processes encircling acinar bases. Activated PSCs exhibit a more pronounced myofibroblastic elongation (up to 20-30 μm in length) and higher expression of glial fibrillary acidic protein (GFAP) alongside α-SMA, differing from HSCs by their stronger association with ductal structures.^[5] In other organs, such as the kidney (renal pericytes with stellate features) and lungs (alveolar myofibroblasts), variations include fewer lipid droplets and more prominent contractile elements even in quiescence, adapting to organ-specific microenvironments like glomerular tufts or alveolar septa. These differences underscore conserved star-shaped designs tailored to local tissue architecture.^[6]

Types and Locations

Cerebellar Stellate Cells

Cerebellar stellate cells reside in the molecular layer of the cerebellar cortex, occupying the outer two-thirds of this layer and positioned strategically between the parallel fibers originating from granule cells and the expansive dendritic arbors of Purkinje cells.^[7] These interneurons feature a characteristic star-shaped morphology with smooth dendrites organized into a planar arbor that aligns parallel to the fan-like dendrites of Purkinje cells, enabling efficient integration within the local circuitry. Their somata are small, typically measuring around 10 μm in diameter, and their dendrites radiate in a twisted, beaded pattern confined primarily to the parasagittal plane, orthogonal to the trajectory of parallel fibers.^[8] In terms of connectivity, cerebellar stellate cells receive excitatory synaptic inputs primarily from granule cell parallel fibers and, to a lesser extent, from glutamate spillover associated with climbing fibers; they also experience inhibitory inputs from neighboring molecular layer interneurons, a subset of Purkinje cells, and possibly Lugaro cells.^[8] Their outputs consist of GABAergic inhibition directed onto the dendrites of Purkinje cells, with axons extending locally within the molecular layer and, in some cases, descending to contribute to pericellular nests around Purkinje cell somata.^[7] This arrangement positions them as key mediators of lateral inhibition among interneurons and direct suppression of principal output neurons. The density of cerebellar stellate cells in the molecular layer is approximately 200–300 cells per 100,000 μm², reflecting their abundance as one of the primary inhibitory interneuron populations, with molecular layer interneurons overall outnumbering Purkinje cells by a ratio of about 10:1.^[9] Specific estimates suggest around 16 stellate cells per Purkinje cell, underscoring their numerical prominence in regulating cortical output. Functionally, these cells contribute to fine-tuning motor coordination by providing rapid feedforward inhibition to Purkinje cells, which enhances the precision of spike timing in response to mossy fiber-granule cell inputs and supports adaptive motor learning processes.^[8] Through this mechanism, approximately seven molecular layer interneurons, including stellate cells, converge on each Purkinje cell to modulate excitability with latencies as short as 1 ms.^[7]

Cortical Stellate Cells

Cortical stellate cells are primarily located in layer IV of the neocortex, serving as key recipients of sensory information in primary sensory areas. In the somatosensory barrel cortex of rodents, spiny stellate cells predominate, comprising up to 76.6% of excitatory neurons in this layer, in contrast to their rarity (about 0.9%) in visual cortex layer IV. These cells exhibit a multipolar morphology with symmetrical, radially oriented dendrites that are largely confined within individual barrel structures, facilitating precise spatial integration of inputs. Their somata are small and round, with extensive dendritic arbors featuring high spine density, which supports numerous synaptic contacts essential for detailed sensory representation.^[10]^[11] The primary inputs to cortical stellate cells are thalamocortical afferents from nuclei such as the ventral posteromedial (VPM) thalamus, which synapse predominantly onto dendritic spines in layer IV, often forming 2-5 contacts per connection. These excitatory synapses primarily utilize AMPA receptors, including calcium-permeable variants, to relay sensory signals with high fidelity. While most stellate cells in this layer are glutamatergic, some GABAergic variants exist as aspiny multipolar interneurons, providing local inhibition within layer IV. Dendrites of spiny stellate cells are oriented toward these thalamic inputs, optimizing reception of whisker-related information in the barrel cortex.^[11]^[12]^[13] Axonal projections from spiny stellate cells ascend vertically from layer IV to superficial layers II and III, targeting pyramidal cells within the same cortical column and providing excitatory drive at connectivity rates of 10-15%. This intracolumnar wiring establishes a hub for vertical signal distribution, enhancing the columnar organization observed in sensory cortices. In the barrel cortex, spiny stellate cells contribute to the formation and maintenance of barrel boundaries by aligning their dendritic and axonal fields with thalamocortical afferents, thereby supporting precise somatotopic mapping of sensory inputs such as whisker deflections.^[11]^[14]^[15]

Other Neural Locations

Stellate cells in layer II of the entorhinal cortex serve as principal excitatory neurons characterized by fan-shaped dendrites that radiate superficially from the soma, often expressing reelin and exhibiting a star-like morphology.^[16] These cells contribute significantly to spatial navigation by forming part of the grid cell network, with approximately 25% displaying grid-like firing patterns that encode self-location through path integration.^[17] They project primarily to the dentate gyrus, CA3, and CA2 regions of the hippocampus, providing a major excitatory input that supports the transformation of spatial representations.^[16] Additionally, these stellate cells exhibit subthreshold membrane potential oscillations in the theta frequency range (4–12 Hz), which facilitate temporal coordination in entorhinal-hippocampal circuits.^[18] In the inferior olivary nucleus, neurons with stellate morphology, featuring multipolar somata and complex, often radial dendritic arbors, generate climbing fibers that project to the cerebellar cortex.^[19] These stellate-like olivary neurons receive inputs from motor and sensory pathways and branch into climbing fibers that synapse onto Purkinje cells, playing a key role in motor coordination and error signaling during cerebellar learning.^[20] Their dendritic trees display asymmetry and extensive branching, contrasting with the more planar, fan-like arrangements in entorhinal stellate cells.^[21] Stellate cells occur rarely in other regions, such as the thalamic reticular nucleus and hippocampal formation, where they exhibit GABAergic properties and contribute to inhibitory modulation. In the thalamic reticular nucleus, these infrequent GABAergic neurons with stellate dendritic distributions help regulate thalamocortical relay activity through burst firing and feedback inhibition.^[22] Similarly, in the hippocampal formation, sparse GABAergic stellate-like interneurons, often with polygonal somata and non-spiny dendrites, provide local inhibition to principal cells, supporting network stability during oscillatory activity.^[23]

Development

Embryonic Origins

Cortical spiny stellate cells, excitatory glutamatergic neurons primarily in layer 4 of sensory cortices, originate from progenitor cells in the ventricular zone (VZ) of the dorsal telencephalon. These cells are generated during mid-embryogenesis, with proliferation peaking between embryonic days E13 and E16 in mice, and they migrate radially along radial glial scaffolds to their laminar positions in the cortical plate.^[24]^[25] In the cerebellum, stellate cell progenitors arise from GABAergic domains in the ventricular zone of the cerebellar anlage, undergoing initial tangential dispersal within the nascent hindbrain structure before further refinement.^[26]^[27]

Postnatal Maturation

During the postnatal period, stellate cells undergo significant refinement to integrate into neural circuits, transitioning from immature precursors to functionally mature neurons through activity-dependent processes. In rodents, this maturation involves the sculpting of dendritic arbors, where initial pyramidal-like morphologies evolve into characteristic stellate patterns via selective pruning and growth, particularly in layer 4 cortical spiny stellate cells.^[28] Dendritic pruning and spine formation in cortical spiny stellate cells peak between postnatal days 10 and 21 (P10-P21) in rodents, driven by sensory-driven neural activity that stabilizes functional connections while eliminating excess branches. For instance, in the visual cortex of ferrets—a model analogous to rodent development—apical dendrites are pruned by P30-P40, with retinal input promoting basal dendrite expansion and spine density increases to support excitatory inputs. In mouse barrel cortex, dendritic orientation toward thalamocortical afferents polarizes by P6, with branching peaking around P10-P30 under the influence of tactile experience.^[28]^[29]^[30] Synaptogenesis in cortical spiny stellate cells establishes their excitatory roles, forming glutamatergic synapses with downstream targets. In the mouse cerebellum, presumptive GABAergic terminals appear on molecular layer interneurons, including stellate cells, as early as P4, marking the onset of basket and stellate differentiation; by P14, functional inhibitory synapses are widespread. Myelination of stellate cell axons follows synaptogenesis, occurring progressively from the second postnatal week onward in rodents, enhancing conduction speed and synchronicity in circuits, particularly for cortical spiny stellate and cerebellar subtypes.^[31]^[32]^[33]^[34]^[35] Critical periods of heightened plasticity shape stellate cell morphology and connectivity through sensory experience. In the rodent barrel cortex, cortical spiny stellate cells in layer 4 refine their dendritic fields and synaptic inputs during P4-P14, with whisker stimulation promoting barrel wall formation and thalamocortical synapse strengthening; deprivation via whisker trimming disrupts this, reducing thalamocortical axon density by approximately 30%. These windows close by P14 for structural changes, limiting further experience-dependent remodeling.^[30]^[36] In cerebellar stellate cells, molecular markers of maturity include the upregulation of parvalbumin, which increases postnatally to regulate calcium dynamics and support fast-spiking properties. In these interneurons, parvalbumin expression rises developmentally from early postnatal stages, peaking in mature cells by P14-P21 to modulate presynaptic release and distinguish stellate from basket subtypes.^[37]^[38] In humans, stellate cell maturation parallels rodent timelines but extends into adolescence, with cortical excitatory circuits refining through synaptic pruning and myelination into the second decade of life. Cerebellar stellate cell development, susceptible to early-life inflammation, continues through childhood, contributing to circuit imbalances observed in neurodevelopmental disorders such as autism spectrum disorder.^[39]^[40]^[41]

Function

Synaptic Integration and Inhibition

Stellate cells in the cerebellar and cortical circuits are primarily GABAergic inhibitory interneurons that release γ-aminobutyric acid (GABA) via the vesicular GABA transporter (VGAT), which loads GABA into synaptic vesicles for exocytotic release.^[42] This mechanism enables fast inhibitory postsynaptic currents (IPSCs) in target neurons, characterized by decay time constants of 10-20 ms, mediated predominantly by GABA_A receptors.^[43] These rapid kinetics allow stellate cells to precisely modulate the timing of postsynaptic activity without prolonged suppression. A key function of stellate cells is providing feedforward inhibition, where they are activated by excitatory inputs—such as parallel fibers in the cerebellum—and subsequently inhibit principal neurons like Purkinje cells to control their firing rates and patterns.^[44] In the cerebellar molecular layer, for instance, this pathway ensures that Purkinje cell output is sculpted to prevent overexcitation, contributing to coordinated motor responses.^[45] Similarly, in cortical layer 4, smooth stellate interneurons participate in feedforward inhibitory loops that balance thalamocortical excitation.^[1] In certain populations, such as cerebellar stellate cells, electrical coupling occurs through connexin36 (Cx36)-containing gap junctions, which synchronize activity among interneurons and enhance network-level inhibition.^[46] This coupling facilitates rapid propagation of signals, allowing coordinated inhibitory barrages that refine circuit dynamics beyond chemical synapses alone.^[45] Stellate cells integrate diverse inputs on their dendrites, including excitatory glutamatergic signals from parallel fibers via AMPA and NMDA receptors, as well as modulatory cholinergic inputs that adjust excitability.^[47] These dendritic computations enable stellate cells to respond dynamically to upstream activity, fine-tuning their inhibitory output to maintain excitation-inhibition balance. Through these mechanisms, stellate cells play a critical role in gain control and temporal processing: in the cerebellum, they sharpen motor timing by limiting Purkinje cell responses to specific frequencies, while in sensory cortical areas, they enhance response selectivity by suppressing weak inputs and refining spatiotemporal patterns.^[47] This contributes to overall circuit precision, such as coordinating movements or filtering sensory information for perceptual acuity.^[45]

Neurovascular Coupling

Stellate cells play a key role in neurovascular coupling, particularly in the cerebellum, where they link local neural activity to adjustments in cerebral blood flow (CBF) to meet metabolic demands. In the cerebellar molecular layer, activation of these GABAergic interneurons, which inhibit Purkinje cells, indirectly modulates vascular tone by balancing excitatory input from parallel fibers with inhibitory output, thereby fine-tuning metabolic signals that influence vasoconstriction or dilation. This process ensures that increased synaptic activity triggers appropriate blood supply without overactivation of downstream circuits.^[48] Cerebellar stellate cells express neuronal nitric oxide synthase (nNOS), enabling them to release nitric oxide (NO), a potent vasodilator, in response to glutamatergic stimulation. This NO release directly acts on intraparenchymal blood vessels and pericytes, promoting dilation independent of astrocytes in some contexts, though interactions within the neurovascular unit involving endothelial cells amplify the response. In cortical regions, certain stellate-like inhibitory interneurons, including those expressing vasoactive intestinal peptide (VIP), contribute similarly by releasing VIP to influence pericyte relaxation and vascular smooth muscle, facilitating localized blood flow adjustments. Stellate cells thus participate in functional hyperemia, where neural activation can increase local CBF by 20-50%; for instance, sensory stimulation in wild-type mice elevates cerebellar blood flow by approximately 32%, an effect markedly reduced (by 69%) in mutants lacking functional stellate cells due to impaired NO signaling.^[49]^[48]^[50] Experimental evidence underscores these mechanisms. Electrophysiological stimulation of single cerebellar stellate cells in acute slices induces NO flux (approximately 0.12 pmol/s) and vasodilates nearby microvessels by about 15% in diameter, confirming a direct functional role in coupling. In vivo, depletion of stellate interneurons suppresses sensory-evoked CBF increases, highlighting their necessity for hyperemic responses. While optogenetic studies in cortical inhibitory populations demonstrate that targeted activation alters capillary diameter through vasoactive mediators like VIP and NPY, leading to biphasic vascular changes (initial dilation followed by constriction >1%), analogous precise manipulations in cerebellar stellate cells further validate their control over local perfusion dynamics.^[51]^[52]^[50]

Pathophysiology

Role in Neurological Disorders

Stellate cells in the cerebellum play a critical role in modulating motor coordination through their inhibitory inputs to Purkinje cells, and their dysfunction contributes to the pathophysiology of spinocerebellar ataxias (SCAs). In SCA1, caused by polyglutamine expansion in the ATXN1 gene, mutant ataxin-1 disrupts cerebellar development by enhancing stem cell proliferation and biasing differentiation toward GABAergic interneurons, including stellate cells, resulting in excessive inhibitory synapses on Purkinje cells and compromised dendritic growth.^[53] This hyperinhibition early in disease progression impairs Purkinje cell function, leading to motor deficits characteristic of ataxia.^[53] In other SCAs, such as SCA17 due to polyglutamine expansion in TBP, degeneration of stellate cells alongside Purkinje and basket cells occurs, potentially reducing inhibitory control and contributing to disinhibition of Purkinje cells, exacerbating impaired motor coordination.^[54] In Alzheimer's disease, entorhinal cortex (EC) stellate cells are among the first affected by tau pathology, with hyperphosphorylated tau accumulating preferentially in layer II stellate neurons, leading to their degeneration.^[55] This selective vulnerability disrupts the spatial firing properties of grid cells, which rely on stellate cell networks for periodic activity, thereby impairing spatial memory and navigation early in the disease.^[55] Postmortem studies confirm tau inclusions and neuronal loss in EC stellate islands as an initial site of pathology in Braak stages I/II, preceding hippocampal involvement.^[56] Stellate cell dysfunction in the medial entorhinal cortex contributes to hyperexcitability in temporal lobe epilepsy (TLE), where reduced recurrent inhibition among layer II stellate cells promotes synchronized bursting and seizure initiation.^[57] In pilocarpine-induced TLE models, layer II stellate cells exhibit prolonged excitatory responses and decreased GABAergic feedback, leading to network hyperexcitability that facilitates epileptiform activity propagation to the hippocampus.^[58] This loss of inhibitory balance, evidenced by fewer GABAergic synapses, underscores stellate cells' role in TLE pathogenesis beyond the traditional focus on hippocampal circuits.^[59] In autism spectrum disorders (ASD), altered migration and connectivity of cortical spiny stellate cells in layer IV of sensory cortices, such as the barrel cortex, disrupt thalamocortical sensory processing. Semaphorin 7A (Sema7A), expressed in spiny stellate cells and GABAergic interneurons, is crucial for their maturation and circuit formation; its deletion in 15q24 microdeletion syndrome, associated with ASD, leads to disrupted barrel cytoarchitecture, reduced dendritic orientation, and impaired whisker sensory mapping.^[60] These developmental abnormalities contribute to sensory hypersensitivity and atypical perceptual integration observed in ASD.^[60] Links between schizophrenia and stellate cell pathology involve dendritic abnormalities in aspiny stellate interneurons of the visual cortex, which interact with thalamocortical circuits to relay sensory information. Postmortem analyses reveal significant reductions in total dendritic length, tortuous branching, and varicosities in aspiny stellate interneurons from schizophrenic brains, indicating structural deficits that impair signal integration.^[61] These changes likely disrupt thalamocortical relay efficiency, contributing to perceptual distortions and cognitive symptoms in schizophrenia.^[61]

Therapeutic and Research Advances

Recent advances in induced pluripotent stem cell (iPSC) technology have enabled the generation of human entorhinal stellate cell-like neurons through forward programming of fibroblasts, providing a platform to investigate grid cell dysfunction in Alzheimer's disease. In a 2022 study, overexpression of transcription factors such as Foxp1 in hiPSCs successfully produced stellate cell-like cells exhibiting characteristic spatial firing patterns and vulnerability to amyloid-beta toxicity, highlighting their utility for modeling entorhinal pathology without relying on postmortem tissue.^[62] Optogenetic approaches have shown promise in modulating stellate cell activity to restore inhibitory balance in epilepsy models. A 2024 investigation in rodent models of mesial temporal lobe epilepsy demonstrated that low-frequency optogenetic stimulation (1 Hz) of medial entorhinal cortex principal cells, which predominantly include stellate neurons, effectively suppressed seizure propagation by enhancing perforant path inhibition, though direct targeting of dentate granule cells yielded mixed results on burst duration and seizure frequency.^[63] These findings build on earlier work by identifying optimal circuit nodes for therapeutic intervention, potentially reducing hyperexcitability linked to temporal lobe seizures. Single-cell RNA sequencing has uncovered significant heterogeneity among stellate cells in the entorhinal cortex, distinguishing subtypes based on marker expression. A 2023 transcriptomic analysis across cortical regions, including the entorhinal cortex, identified 24 conserved cell types with layer-specific variations, revealing that layer II stellate cells exhibit distinct transcriptional profiles related to synaptic integration, though excitatory stellate populations showed less divergence than inhibitory subtypes like parvalbumin-positive (PV+) or vasoactive intestinal peptide-positive (VIP+) interneurons interacting with them. Complementary 2024 studies using Patch-seq confirmed spatial organization in stellate-PV+ connectivity, underscoring subtype-specific roles in grid cell clustering.^[65] Therapeutic strategies involving CRISPR editing target developmental genes to address stellate cell-related deficits in autism spectrum disorder models. Editing of Dlx1/2 genes, which regulate GABAergic interneuron specification, has been explored to correct migration and inhibitory deficits impacting entorhinal circuits; a 2023 CRISPR screen in human assembloids identified Dlx pathway disruptions as key contributors to interneuron hypoplasia, indirectly affecting excitatory stellate function and social behavior phenotypes in rodent autism models.^[66] This approach holds potential for restoring circuit balance in neurodevelopmental disorders. Advances in two-photon microscopy have facilitated in vivo tracking of stellate cell dynamics, linking neuronal activity to neurovascular responses. Subsequent refinements from 2023-2025 have improved depth penetration and resolution, enabling longitudinal studies of stellate-vascular interactions in disease contexts like epilepsy.^[67]

References

[1]
Stellate Cells in Tissue Repair, Inflammation, and Cancer
Jul 20, 2018 · Abstract. Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic state in ...
[2]
Hepatic Stellate Cells in Physiology and Pathology - PMC
Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury.
[3]
Pancreatic Stellate Cells: A Rising Translational Physiology Star as ...
Mar 11, 2019 · Pancreatic stellate cells (PSCs) are a multifunctional cell type found in endocrine and exocrine pancreatic tissue and comprising about 7% of ...
[4]
Hepatic stellate cells in liver development, regeneration, and cancer
Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver physiology and fibrogenesis.
[5]
Synaptic relationships of a type of GABA-immunoreactive ... - PubMed
... stellate cells ... The slightly ovoid somata were 8-12 micron by 12-15 micron and the dendritic field was often elongated, extending 80-200 micron in one ...Missing: size | Show results with:size
[6]
Local targets of T‐stellate cells in the ventral cochlear nucleus
Jun 18, 2022 · The average diameter of T-stellate cells was 17.23 ± 2.42 μm, which is consistent with previous observations (Wu & Oertel, 1984), and the ...3 Results · 3.2 T-Stellate Cells Synapse... · 3.4 T-Stellate Cells Target...
[7]
Stellate Cell - an overview | ScienceDirect Topics
Stellate cells are neurons distinguished by their star-shaped, multipolar morphology, with rounded cell bodies and dendrites that project in multiple directions ...
[8]
Smooth and sparsely‐spined stellate cells in the visual cortex of the rat
Sep 1, 1978 · The dendrites also had both symmetric and asymmetric synapses along their shafts, with the symmetric synapses being more frequent on the ...
[9]
Relationships between Dendritic Fields and Functional Architecture ...
Dec 9, 1994 · The only significant dif- ference between the two groups of neurons was found in the number of dendrites: spiny stellate cells possessed four to ...
[10]
A Journey Through the Brain - Classification of Neurons
Apr 9, 2002 · Neurons with very long axons that extend from on area of the brain to another are the Golgi Type I, while those with short, local circuit axons ...
[11]
The stellate cells of the rat's cerebellar cortex | Brain Structure and ...
Axons can be recognized on the basis of their appearance in Golgi preparations as short stretches of slender fibers distended at close intervals and running ...
[12]
Estimating functional connectivity in an electrically coupled ... - PNAS
Nov 18, 2013 · In the cerebellar cortex, anatomical and functional evidence indicates electrical coupling between molecular layer interneurons (basket and ...
[13]
Modernization of Golgi staining techniques for high-resolution, 3 ...
Jan 15, 2019 · We describe the first successful use of a Golgi-based staining technique for tracing neurons over their entire length with preservation of ultrastructural ...
[14]
Dendritic Branch Typing and Spine Expression Patterns in Cortical ...
The initial branching pattern, internode interval and spine density at the light microscopic level divided nonpyramidal cells into three dendritic types, ...Results · Dendritic Branching And... · Dendritic Spine...
[15]
Functions of Interneurons in Mouse Cerebellum
Jan 30, 2008 · Stellate cell inhibitory axon terminals synapse directly on Purkinje cell smooth dendrites (Eccles et al., 1965; Fox et al., 1967). Golgi ...
[16]
Functional and structural specific roles of activity-driven BDNF within ...
Spiny stellate cells were identified based on enriched dendritic spines and the absence of apical dendrites extending out of layer IV into supragranular layers ...
[17]
What Does the Anatomical Organization of the Entorhinal Cortex Tell ...
Aug 28, 2008 · This dendritic morphology is thus comparable to that of stellate cells in MEC. The morphological difference is that fan cells only have ...<|separator|>
[18]
The Entorhinal Cortex | The Hippocampus Book - Oxford Academic
Jan 1, 2025 · Fan cells, originally referred to as stellate-like cells, were renamed since they lack a distinct basal dendritic tree and have extremely large ...
[19]
Cerebellum - Scholarpedia
Jul 6, 2015 · The smallest stellate cells, in the most superficial regions of the molecular layer, have 5 to 9 µm-diameter somata, a few radial dendrites, and ...
[20]
Columnar Organization of Dendrites and Axons of Single and ...
Jul 15, 2000 · As shown for spiny stellate cells, axonal collaterals were largely confined to a single cortical column. The main axon emerges either ...Missing: wider | Show results with:wider
[21]
Functions of Interneurons in Mouse Cerebellum - PMC
2 D). Stellate cells have small cell bodies (8–12 μm) and multiple sparsely branched (“stellate”) dendrites, confined to the molecular layer (Fig ...
[22]
Functional Diversity of Layer IV Spiny Neurons in Rat ...
Spiny stellate cells lacked an apical dendrite and frequently confined their dendritic and axonal arbors to the respective column. Star pyramidal and pyramidal ...Materials And Methods · Spiny Stellate Neurons · Pyramidal Neurons
[23]
Types and Distribution of Synapses Upon Basket and Stellate Cells ...
Types and Distribution of Synapses Upon Basket and Stellate Cells of the Mouse Cerebellum: An Electron Microscopic Study.Missing: specializations like
[24]
Distinctive Properties of Pyramidal and Stellate Neurons
Dendrites of stellate cells were generally oriented at right angles to the apical dendrites of the pyramidal neurons and parallel to the pial surface. The ...
[25]
https://pmc.ncbi.nlm.nih.gov/articles/PMC2885865/
[26]
https://pmc.ncbi.nlm.nih.gov/articles/PMC1950908/
[27]
https://www.jneurosci.org/content/26/45/11682
[28]
Layer 4 of mouse neocortex differs in cell types and circuit ... - Nature
Sep 13, 2019 · Spiny stellate cells have been reported to be the dominant excitatory cell type, both in rat and in mouse (as a result of sculpting of initially ...
[29]
Excitatory neuronal connectivity in the barrel cortex - Frontiers
The neuronal targets of thalamocortical afferents in layer 4 are spiny stellate cells, star pyramids, and L4 pyramidal neurons (Brecht and Sakmann, 2002a; ...Vertical Organization of... · Intracortical Excitation · Long-Range Connections...
[30]
Monosynaptic Connections between Pairs of Spiny Stellate Cells in ...
Mar 30, 2005 · Monosynaptic interlaminar connections between spiny stellate cells in layer 4 (L4), the main cortical recipient layer for thalamic projections, and pyramidal ...<|control11|><|separator|>
[31]
Synaptic relationships of a type of GABA-immunoreactive neuron ...
The results show that layer IVC in the monkey has a specialized GABAergic neuron that terminates on spiny stellate cells monosynaptically innervated from the ...Missing: neocortex | Show results with:neocortex
[32]
Impact of Thalamocortical Input on Barrel Cortex Development - PMC
Apr 13, 2017 · In these mosaic animals, as expected, L4 wild type spiny stellate cells are localized at barrels edges and develop asymmetric dendrites biased ...
[33]
Functional properties of stellate cells in medial entorhinal cortex ...
Sep 14, 2018 · Accumulating evidence suggests that these two cell types have distinct molecular profiles, physiological properties, and connectivity.
[34]
Functional properties of stellate cells in medial entorhinal cortex ...
Sep 14, 2018 · Stellate cells in the medial entorhinal cortex are functionally heterogeneous but a substantial fraction are grid cells.
[35]
Intrinsic electrophysiological properties of entorhinal cortex stellate ...
Apr 23, 2012 · Stellate cells in layer II of the medial entorhinal cortex (MEC) are a crucial component of the neural circuit for representation of space.
[36]
Migratory Pathways and Neuritic Differentiation of Inferior Olivary ...
Mar 1, 1988 · Migratory Pathways and Neuritic Differentiation of Inferior Olivary Neurons in the Rat Embryo. ... stellate form, with long and straight ...
[37]
Neuroanatomy, Superior and Inferior Olivary Nucleus ... - NCBI
Jul 24, 2023 · After receiving motor and sensory inputs, the axons of inferior olive neurons branch into several climbing and mossy fibers (CF and MF) that ...Missing: stellate | Show results with:stellate
[38]
Classification by morphology of multipolar neurons of the human ...
Nearly all neurons in this nucleus is multipolar along with having a highly complex dendritic tree and significant asymmetry in shape.
[39]
[PDF] thalamus
and from cells in the thalamic reticular nucleus. Other modulatory inputs ... Because reticular neurons provide an inhibitory, GABAergic input to thalamic relay.<|separator|>
[40]
Characterization of GABAergic neurons in hippocampal cell cultures
Most GABAergic cells had more fusiform or polygonal shaped somata, non-spiny and less tapering dendrites and appeared more phase-dense than nonGABAergic cells.
[41]
Development of Cortical GABAergic Innervation - PMC
Jul 14, 2011 · The vast majority of cortical interneurons are not born in the ventricular zone, but in the medial and caudal ganglionic eminence in the ventral ...
[42]
Development and specification of GABAergic cortical interneurons
Apr 23, 2013 · The medial ganglionic eminence has long been regarded as a primary source of GABAergic cortical interneurons; it is thought to be the site of ...
[43]
Dlx1&2 and Mash1 Transcription Factors Control MGE and CGE ...
Apr 22, 2009 · Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.Dlx1&2 And Mash1... · Rna Preparation And Gene... · Dlx1&2;Mash1 Compound...
[44]
Nkx2.1 regulates the generation of telencephalic astrocytes during ...
Mar 7, 2017 · The homeodomain transcription factor Nkx2.1 (NK2 homeobox 1) controls cell differentiation of telencephalic GABAergic interneurons and ...Missing: stellate | Show results with:stellate
[45]
The Temporal and Spatial Origins of Cortical Interneurons Predict ...
Nov 23, 2005 · We provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic ...<|separator|>
[46]
Radial Glial Dependent and Independent Dynamics of Interneuronal ...
Aug 29, 2007 · Previously, it was suggested that tangential migration of interneurons occurs in a radial glia independent manner. Here, using simultaneous ...Missing: stellate | Show results with:stellate
[47]
Different Types of Cerebellar GABAergic Interneurons Originate from ...
Nov 8, 2006 · During postnatal development, the cerebellar cortex is greatly expanding, and, hence, basket and stellate cells may be more frequently generated ...
[48]
Developmental Sculpting of Dendritic Morphology of Layer 4 ... - NIH
Our results demonstrate that cortical spiny stellate neurons emerge by differential sculpting of the dendritic arborizations of an initial pyramidal morphology ...
[49]
https://www.jneurosci.org/content/20/18/6968
[50]
Development and Critical Period Plasticity of the Barrel Cortex - PMC
Trigeminal ganglion cells are responsive to whisker stimulation ... Early experience of tactile stimulation influences organization of somatic sensory cortex.The Barrel Cortex · Table 1 · Glia, Perineuronal Nets And...
[51]
GABAergic synaptogenesis marks the onset of differentiation of ...
Sep 24, 2007 · These results suggest that GABAergic synaptogenesis marks the onset of differentiation of basket and stellate cells in the mouse cerebellum.Missing: P14 myelination axons
[52]
Quantitative Organization of GABAergic Synapses in the Molecular ...
In the cerebellar cortex, interneurons of the molecular layer (stellate and basket cells) provide GABAergic input to Purkinje cells, as well as to each ...
[53]
Synaptogenesis of Electrical and GABAergic Synapses of Fast ...
Jul 27, 2011 · Here, we found that GABAergic connections among L5/6 FS cells as well as between L5/6 FS cells and pyramidal cells can first be detected at P5 ...
[54]
Development of myelinating glia: An overview - PubMed Central - NIH
In the mouse brain, myelination peaks between 2–4 weeks after birth, and continues for at least 8 postnatal months at a decreasing rate (Rivers et al., 2008).
[55]
Myelination of parvalbumin interneurons shapes the function of ...
Oct 13, 2020 · Myelination of projection neurons by oligodendrocytes is key to optimize action potential conduction over long distances.
[56]
https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.054671
[57]
Developmental Changes in Parvalbumin Regulate Presynaptic Ca 2 ...
Jan 5, 2005 · Here we show that expression of the slow CBP parvalbumin (PV) in cerebellar interneurons is cell specific and developmentally regulated, leading ...
[58]
Developmental Changes in Parvalbumin Regulate Presynaptic ...
These data suggest that the difference between the decay kinetics of basket and stellate cells observed at this age is directly determined by the level of PV ...
[59]
Maturation of the Human Cerebral Cortex During Adolescence - NIH
Aug 28, 2018 · Previous in vivo studies revealed robust age-related variations in structural properties of the human cerebral cortex during adolescence.
[60]
A single-cell genomic atlas for maturation of the human cerebellum ...
Our results further establish the impact of early-life inflammation on cerebellar development and its potential relevance to neurodevelopmental disorders.
[61]
The Epigenome in Neurodevelopmental Disorders - Frontiers
Studies of children with neurodevelopmental defects indicate that DNA methylation and histone modification are crucial for normal brain development (Cristancho ...
[62]
The Vesicular GABA Transporter, VGAT, Localizes to Synaptic ...
VGAT is highly concentrated in the nerve endings of GABAergic neurons in the brain and spinal cord but also in glycinergic nerve endings.
[63]
Setting the Time Course of Inhibitory Synaptic Currents by Mixing ...
Apr 25, 2012 · This 0.5 ms rise time subselection had very little effect on the mIPSC decay. In stellate/basket cells, the τw of mIPSCs with 10–90% rise time < ...
[64]
Target-Dependent Feedforward Inhibition in Cerebellum
Jun 16, 2010 · Cerebellar feedforward inhibition (FFI) is mediated by two distinct pathways targeting different subcellular compartments of Purkinje cells (PCs).
[65]
Diverse Neuron Properties and Complex Network Dynamics in the ...
These dendrites are very long (from 100 μm to 700 μm) and can ascend obliquely towards the ML and/or extend down more or less vertically through the GL (Lainé ...<|control11|><|separator|>
[66]
Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex - PubMed
Electrical synapses formed by connexin36 (Cx36)-containing gap junctions between interneurons in the cerebellar cortex have been well characterized, ...
[67]
Stellate cell computational modeling predicts signal filtering in the ...
Feb 16, 2021 · The morphologies consisted of branched dendritic trees, a soma, and a branched axon with collaterals (the axon is short and unmyelinated).
[68]
Stellate Neurons Mediate Functional Hyperemia in the Cerebellar ...
The data provide evidence that stellate neurons are a critical link between neural activity and blood flow in the activated cerebellum.
[69]
Stellate Neurons Mediate Functional Hyperemia in the Cerebellar ...
Sep 15, 2000 · Therefore, in the cerebellar molecular layer, stellate neurons might be directly involved in coupling synaptic activity to blood flow. However, ...
[70]
Cell type specificity of neurovascular coupling in cerebral cortex - eLife
May 31, 2016 · We demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism ...Missing: stellate | Show results with:stellate
[71]
(PDF) Stellate cells release NO and induce vasodilation of ...
Aug 6, 2025 · Stellate cells release NO and induce vasodilation of intraparenchymal blood vessels in rat cerebellar slices. August 2005; Journal of cerebral ...Missing: intracerebral | Show results with:intracerebral
[72]
[PDF] Revisiting the neurovascular unit - Neuroscience Institute
Supporting the involvement of interneurons, depletion of cerebellar interneurons. (stellate cells) suppresses the increase in CBF induced by sensory ... Brain ...
[73]
Mutant ataxin1 disrupts cerebellar development in spinocerebellar ...
We found that expanded ATXN1 stimulates the proliferation of postnatal cerebellar stem cells in SCA1 mice. These hyperproliferating stem cells tended to ...
[74]
A Novel Transgenic Rat Model for Spinocerebellar Ataxia Type 17 ...
May 22, 2013 · Degeneration of Purkinje, basket, and stellate cells, changes in the morphology of the dendrites, nuclear TBP-positive immunoreactivity, and ...Ataxia Score Test · Rotarod Analysis · Results
[75]
Subcellular localization of PDE4D and HCN1 in rhesus macaque ...
Feb 1, 2022 · Anatomical studies in AD subjects and rhesus macaques show earliest signs of tau pathology in the stellate cell islands in entorhinal cortex ( ...
[76]
Recurrent Circuits in Layer II of Medial Entorhinal Cortex in a Model ...
Feb 7, 2007 · In animal models of temporal lobe epilepsy, stellate cells display prolonged excitatory synaptic responses when stimulated (Bear et al., 1996; ...
[77]
Recurrent circuits in layer II of medial entorhinal cortex in a model of ...
These findings suggest that in this model of temporal lobe epilepsy, reduced recurrent inhibition contributes to layer II stellate cell hyperexcitability ...
[78]
Hyperexcitability, Interneurons, and Loss of GABAergic Synapses in ...
Apr 26, 2006 · In animal models of temporal lobe epilepsy, layer II stellate cells are hyperexcitable (Bear et al., 1996; Scharfman et al., 1998; Tolner et al.
[79]
Maturation of cortical circuits requires Semaphorin 7A - PNAS
Sep 8, 2014 · In humans, microdeletions in chromosome 15q24, which include SEMA7A, are associated with a syndrome characterized by autism, developmental delay ...Results · Sema7a Becomes Enriched In... · Disrupted Gabaergic Neuron...
[80]
Morphological alterations of the pyramidal and stellate cells of ... - NIH
Apr 22, 2021 · Aspiny stellate interneurons of the visual cortex from the schizophrenic brains exhibited a significant decrease of the total dendritic length ( ...
[81]
https://pmc.ncbi.nlm.nih.gov/articles/PMC8111868
[82]
Production of human entorhinal stellate cell-like cells by forward ...
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer's ...
[83]
https://www.brainstimjrnl.com/article/S1935-861X(24
[84]
Transcriptomic cytoarchitecture reveals principles of human ...
Oct 13, 2023 · Single-nucleus RNA-sequencing of 8 areas spanning cortical structural variation showed a highly consistent cellular makeup for 24 cell ...
[85]
Synaptic interactions between stellate cells and parvalbumin ... - eLife
Nov 1, 2024 · In this compelling study, the authors examine the interactions between stellate cells and PV+ interneurons in the medial entorhinal cortex.
[86]
Impact of genes linked to neurodevelopmental diseases found
Sep 27, 2023 · Researchers revealed the impact of a multitude of genes that are associated with neurodevelopmental disorders, including autism, but whose effects on human ...Missing: Dlx stellate
[87]
In vivo two-photon microscopy for studies of neurovascular coupling ...
Nov 4, 2025 · To investigate the dynamic complexity of NVC in vivo, two-photon microscopy (TPM) provides excellent spatial and temporal resolution, enabling ...