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Urodynamic testing

Urodynamic testing refers to a series of diagnostic procedures that evaluate the function of the lower urinary tract, including the bladder, sphincters, and urethra, to determine how effectively they store and release urine.^[1] These tests are particularly useful for identifying problems such as urinary incontinence, overactive bladder, blockages, or incomplete bladder emptying, which can cause symptoms like frequent urination, urgency, or leakage.^[2] By measuring parameters like bladder pressure, urine flow rate, and muscle activity, urodynamic testing helps clinicians diagnose underlying causes of lower urinary tract dysfunction and guide appropriate treatments.^[3] The primary purposes of urodynamic testing include assessing bladder capacity, detecting involuntary contractions, evaluating sphincter competence, and identifying obstructions in the urinary pathway.^[1] It is commonly recommended for patients with unexplained urinary symptoms, neurogenic bladder conditions, or those preparing for surgical interventions like sling procedures or prostate surgery, though its routine use in uncomplicated stress urinary incontinence remains controversial according to guidelines such as those from the American Urological Association/Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (AUA/SUFU).^[2]^[4] Unlike simple urine tests, these procedures provide dynamic, real-time data on the coordination between the bladder's storage and voiding phases, which is essential for distinguishing between conditions like stress incontinence and urge incontinence.^[3] Common types of urodynamic tests include uroflowmetry, cystometry, pressure-flow studies, electromyography, postvoid residual measurement, and video urodynamics, often performed in combination for a comprehensive evaluation.^[1]^[2] These tests are typically conducted in an outpatient setting, lasting 30 to 60 minutes, and traditionally involve catheter insertion, though as of 2025, emerging wireless and catheter-free technologies are being adopted to improve patient comfort and reduce risks like infection.^[1]^[5]

Background

Definition and Purpose

Urodynamic testing refers to a series of diagnostic procedures that evaluate the function and dysfunction of the lower urinary tract by measuring key physiological parameters, including bladder pressure, urine flow rate, and sphincter activity.^[6] These tests provide an objective assessment of how the bladder, sphincters, and urethra coordinate to store urine during the filling phase and release it during the voiding phase of micturition.^[1] Specifically, urodynamics is defined as the dynamic study of urine transport, storage, and evacuation, involving interactive measurements such as intravesical and detrusor pressures, urinary flow, and electromyographic signals from the pelvic floor muscles.^[4] The primary purpose of urodynamic testing is to diagnose the underlying causes of lower urinary tract symptoms (LUTS), such as urinary incontinence, retention, frequency, urgency, or weak stream, particularly when patient history and basic clinical examinations yield inconclusive results.^[1] By reproducing and quantifying symptoms under controlled conditions, these tests offer definitive insights into bladder and outlet pathophysiology, enabling clinicians to distinguish between storage and voiding disorders.^[4] This objective data is crucial for guiding treatment selection, including conservative management, pharmacotherapy, or surgical interventions, especially in complex cases like neurogenic bladder or when planning invasive procedures.^[6] A fundamental concept in urodynamic testing is the distinction between storage (continence) dysfunction, which involves issues like detrusor overactivity or reduced bladder compliance leading to involuntary leakage or urgency, and voiding (emptying) dysfunction, characterized by impaired detrusor contractility or bladder outlet obstruction resulting in hesitancy or incomplete emptying.^[6] These evaluations confirm pathologies that extend beyond subjective symptoms, providing evidence-based support for therapeutic decisions and improving outcomes in patients with refractory LUTS.^[4]

Historical Development

Urodynamic testing traces its roots to early 20th-century efforts in cystometry, but significant advancements began in the mid-20th century with the development of techniques to measure bladder and urethral pressures simultaneously. In 1961, Göran Enhörning pioneered the simultaneous recording of intravesical and intraurethral pressures using a specialized catheter, enabling the study of urethral closure mechanisms in normal and stress incontinent women.^[7] This work laid the foundation for understanding pressure dynamics in the lower urinary tract. Concurrently, uroflowmetry emerged as a non-invasive method to assess voiding function; Willard M. Drake Jr. invented the modern uroflowmeter in 1946, an apparatus that quantified urine flow rates to aid in evaluating lower urinary tract disorders, though its widespread clinical adoption occurred in the 1960s.^[8] By the late 1950s, integrated laboratories, such as Earl R. Miller's at the University of California, San Francisco in 1958, combined cystometry, uroflowmetry, and cinefluoroscopy to provide comprehensive evaluations of micturition abnormalities.^[9] The 1970s marked a pivotal era with the transition to multichannel urodynamic systems that incorporated pressure-flow dynamics and imaging for more holistic assessments. Around 1970, multichannel setups gained recognition, allowing simultaneous measurement of multiple parameters like bladder pressure, abdominal pressure, and flow during filling and voiding phases, which proved essential for diagnosing complex voiding dysfunctions.^[9] C. P. Bates and colleagues advanced this further in 1970 by introducing synchronous cine/pressure/flow cystography, a technique that synchronized radiographic imaging with pressure and flow recordings to visualize dynamic events in real time, particularly for stress incontinence.^[10] The formation of the Urodynamics Society in 1965 and its first official meeting in 1969 further propelled the field, fostering collaboration among researchers.^[9] Standardization efforts began with the International Continence Society's (ICS) first report on terminology for lower urinary tract function in 1976, which provided unified definitions for urodynamic observations and symptoms to facilitate consistent research and clinical application.^[11] In the 1980s, the ICS continued pushing for standardization through subsequent reports and the launch of the journal Neurourology and Urodynamics in 1982, which dedicated space to methodological refinements and clinical correlations.^[9] The 1990s saw a shift toward video urodynamics for enhanced dynamic imaging, building on 1970s foundations to integrate fluoroscopy more routinely into multichannel studies for precise anatomical-functional correlations.^[12] Overall, the evolution progressed from invasive, single-parameter tests like basic cystometry to comprehensive, multichannel evaluations that captured the interplay of storage and voiding phases. Post-2000, digital technology transformed urodynamic testing by enabling computer-assisted, real-time data analysis and storage, improving accuracy in multichannel systems and facilitating video urodynamics in the digital age.^[13] This integration allowed for automated processing of pressure-flow curves and imaging, reducing operator variability and enhancing diagnostic precision in clinical practice. Notable contributions from urologists such as Victor F. Marshall, who advanced treatments for stress urinary incontinence through early physiological insights, underscored the field's growth in addressing lower urinary tract disorders.^[14] In the 2020s, as of 2025, further innovations include wireless, catheter-free urodynamic systems for ambulatory monitoring and artificial intelligence for predictive analytics in interpreting test results, making procedures less invasive and more accessible.^[15]

Clinical Considerations

Indications

Urodynamic testing is primarily indicated for evaluating persistent stress urinary incontinence (SUI) or urgency urinary incontinence (UUI) that does not respond to initial conservative management, such as pelvic floor exercises or lifestyle modifications.^[4] It is also recommended for assessing neurogenic bladder dysfunction in patients with conditions like spinal cord injury or multiple sclerosis, where it helps identify detrusor overactivity, poor compliance, or detrusor-sphincter dyssynergia that could lead to upper urinary tract complications.^[4] In men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH), testing is advised to differentiate bladder outlet obstruction from detrusor underactivity, particularly prior to invasive interventions.^[4] For pediatric patients, indications include refractory enuresis or voiding dysfunction with significant daytime symptoms, such as recurrent urinary tract infections or incomplete emptying, after failure of behavioral therapies.^[16] Secondary applications encompass preoperative evaluation for procedures like midurethral slings in SUI or prostatectomy in BPH, where testing confirms urodynamic SUI or quantifies obstruction to guide surgical planning.^[4] It is useful in assessing treatment failure for overactive bladder (OAB), especially in cases of mixed incontinence or when upper tract risks, such as hydronephrosis, are suspected due to elevated post-void residual volumes.^[4] Additionally, in complex scenarios involving neurogenic conditions or post-surgical complications, urodynamics aids in tailoring therapies like sacral neuromodulation or botulinum toxin injections.^[4] These indications are supported by the American Urological Association (AUA)/Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) guidelines, which endorse selective use based on clinical evidence from randomized trials and cohort studies, with a 2012 adult urodynamics guideline providing graded recommendations.^[4] The 2024 AUA/SUFU OAB guideline amendment reinforces this by emphasizing urodynamics only in cases of diagnostic uncertainty or non-response to pharmacotherapy, avoiding routine application in uncomplicated OAB to reduce unnecessary testing.^[17] This approach aligns with the Choosing Wisely campaign's recommendation against initial urodynamics in straightforward OAB presentations, promoting cost-effective care.^[18] Patient selection prioritizes individuals whose symptoms, such as urgency or leakage, do not align with findings from basic evaluations like urinalysis, bladder ultrasound, or post-void residual measurement, ensuring testing addresses diagnostic gaps without overuse.^[4]

Contraindications and Risks

Urodynamic testing carries specific contraindications to prevent harm, with active urinary tract infection (UTI) serving as the primary absolute contraindication, necessitating postponement of the procedure until the infection is adequately treated.^[6] Untreated urethral stricture also represents an absolute contraindication due to the risk of exacerbating obstruction or causing trauma during catheterization.^[19] Relative contraindications include conditions that may increase procedural risks or compromise test validity without fully precluding testing. These encompass anticoagulation therapy, which elevates the potential for bleeding during catheterization, though continuation is often feasible with careful monitoring.^[20] Patients with severe cognitive impairment or inability to provide informed consent and comply with instructions pose challenges for accurate assessment and safety.^[6] Recent pelvic surgery is considered relative, as it may heighten risks of infection or trauma in the healing area.^[20] In individuals with spinal cord injury above T6, autonomic dysreflexia triggered by bladder distention or instrumentation is a significant relative contraindication, potentially leading to life-threatening hypertensive crises if not preemptively managed.^[4] For video urodynamics specifically, absolute contraindications include iodine or contrast allergies and patient refusal of radiation exposure, while relative ones involve impaired renal function or balance issues that could affect positioning.^[21] The primary risks associated with urodynamic testing arise from urethral catheterization used in invasive components, including discomfort or pain during the procedure, which is commonly reported but typically transient.^[22] Urinary tract infection is a notable complication, with bacteriuria occurring in 4-9% of cases and symptomatic UTI incidence ranging from 1-5%, particularly higher in patients with recurrent UTIs or neurogenic bladder.^[22]^[23] Rare adverse events include hematuria and urinary retention, while bladder perforation remains exceptionally uncommon at less than 0.1%.^[6] In video urodynamics, additional risks involve low-level radiation exposure and potential allergic reactions to contrast media.^[21] Overall complication rates are low, emphasizing the procedure's safety profile when appropriately selected.^[24] To mitigate these risks, prophylactic antibiotics are recommended for high-risk patients, such as those with neurogenic lower urinary tract dysfunction or elevated post-void residual volume, to reduce UTI incidence.^[6] Thorough informed consent is essential, highlighting the low overall complication rate and transient nature of most side effects, alongside post-procedure monitoring for infection signs like fever or dysuria.^[1] For patients on anticoagulation, procedural adjustments or hematologic consultation may further minimize bleeding risks.^[20]

Patient Preparation

Pre-Test Evaluation

Prior to undergoing urodynamic testing, a thorough pre-test evaluation is essential to ensure appropriate patient selection, accurate interpretation of results, and minimization of risks. This evaluation begins with a detailed clinical history, which includes a validated symptom questionnaire such as the International Prostate Symptom Score (IPSS) to quantify lower urinary tract symptoms (LUTS) like frequency, urgency, and nocturia in patients with benign prostatic hyperplasia or other LUTS conditions.^[25] Additionally, patients are typically instructed to maintain a 3-day voiding diary, recording voiding frequency, volumes, incontinence episodes, and fluid intake to provide objective data on bladder habits and symptom patterns.^[25] A comprehensive physical examination follows, encompassing a pelvic examination in females to assess for prolapse or masses, a neurological evaluation including gait, sacral sensation, and reflexes to identify potential neurogenic contributions, and an external genitalia or digital rectal examination in males to evaluate prostate size or other abnormalities.^[6] Laboratory assessments are also critical, starting with urinalysis to exclude urinary tract infection or hematuria, which could confound test results or indicate alternative pathologies.^[6] Post-void residual (PVR) volume is measured noninvasively via bladder ultrasound to detect retention, serving as a safety check before invasive procedures.^[4] If upper urinary tract involvement is suspected, such as in cases of suspected obstruction or neurogenic bladder, renal function tests including serum creatinine and electrolytes are recommended to assess for potential complications like hydronephrosis.^[6] Informed consent is obtained after a detailed discussion of the procedure, including its indications, potential risks such as discomfort, infection, or hematuria, benefits for guiding treatment, and what patients can expect during the test, with written information provided to enhance understanding.^[6] A medication review is conducted to identify and manage drugs affecting bladder function; anticholinergics should be withheld for 48 hours prior if clinically safe to avoid masking detrusor overactivity, while alpha-blockers may also be paused for 24-48 hours per guidelines to permit unadulterated assessment of voiding dynamics, though continuation is advised if discontinuation poses risks.^[6]^[26]

Procedural Preparation

Patients undergoing urodynamic testing are instructed to arrive with a comfortably full bladder to facilitate initial uroflowmetry, typically achieved by drinking 500-1000 ml of water approximately one hour prior to the appointment and avoiding urination until the test begins.^[6] Emptying the bowels beforehand, if possible, is recommended to minimize discomfort during catheterization, while wearing loose clothing aids in easy access for electrode and catheter placement.^[2] Patients receive explanations of expected sensations, such as the urge to void during bladder filling, to reduce anxiety in the private testing environment provided.^[27] Technical preparation involves calibrating pressure transducers to zero at atmospheric pressure, with the reference level set at the superior border of the symphysis pubis, followed by a cough test to verify equal pressure transmission between channels.^[6] Catheters, usually 6-7 French in size and fluid-filled, are selected and prepared, along with a filling medium of sterile saline or water warmed to body temperature for infusion at a physiological rate of 20-50 ml/min.^[28] Patient positioning begins supine for catheter insertion, transitioning to sitting for men or semi-reclined for women to replicate natural voiding postures during the procedure.^[6] Infection control emphasizes aseptic technique throughout catheterization, using sterile gloves, antiseptic wipes, and lubricant gel to minimize urinary tract infection risk.^[28] Prophylactic antibiotics are considered for high-risk patients, such as those with immunosuppression or known urinary tract abnormalities, though routine use is not recommended due to limited evidence of benefit in low-risk cases.^[29]

Diagnostic Tests

Uroflowmetry and Post-Void Residual Measurement

Uroflowmetry is a noninvasive urodynamic test that evaluates the flow dynamics of urination by measuring the rate and pattern of urine expulsion from the bladder. During the procedure, the patient voids spontaneously into a specialized uroflowmeter device, typically in their preferred position, such as standing for men or sitting for women, while ensuring a voided volume of at least 150 mL for reliable results.^[6]^[25] The test captures key parameters including the maximum flow rate (Qmax), voided volume, time to peak flow, and total voiding time, which is often around 20-30 seconds in normal voids.^[4] This simple, office-based assessment requires no catheterization or instrumentation of the urinary tract, making it quick and patient-friendly, with the entire process lasting only a few minutes.^[6] Post-void residual (PVR) measurement complements uroflowmetry by quantifying the volume of urine remaining in the bladder immediately after voiding, providing insight into bladder emptying efficiency. PVR is determined noninvasively using transabdominal ultrasound or a portable bladder scanner, or via intermittent catheterization if higher precision is needed.^[4]^[25] Elevated PVR volumes, generally exceeding 100-300 mL depending on context, signal potential incomplete emptying, which may stem from outlet obstruction or detrusor underactivity.^[30] The measurement is performed promptly after uroflowmetry to avoid reaccumulation of urine, ensuring accuracy in assessing residual status.^[4] The primary equipment for these tests is an electronic uroflowmeter, a compact device that collects urine in a commode-like container equipped with sensors to detect weight or volume changes over time, generating a graphical flow curve for analysis.^[6] Normal flow patterns appear bell-shaped, peaking smoothly, whereas abnormal curves may show prolonged plateaus indicative of obstruction, though detailed interpretation requires clinical correlation.^[4] For PVR, ultrasound devices offer a radiation-free, repeatable alternative to catheterization, with both methods validated for clinical use in outpatient settings.^[25] Clinically, uroflowmetry and PVR measurement serve as initial screening tools for lower urinary tract symptoms (LUTS), particularly in evaluating suspected bladder outlet obstruction or detrusor weakness in conditions like benign prostatic hyperplasia or neurogenic bladder.^[4]^[6] These tests are highly repeatable, cost-effective, and devoid of radiation exposure, allowing for serial monitoring of treatment efficacy without invasive risks.^[25] According to AUA/SUFU guidelines, uroflowmetry is recommended for initial assessment of male LUTS suggestive of voiding dysfunction, while PVR is a standard for neurogenic bladder evaluation to guide management and prevent complications like urinary retention.^[4]

Cystometry and Pressure-Flow Studies

Cystometry is an invasive urodynamic test that evaluates bladder function during the filling phase by measuring the pressure-volume relationship in the bladder. The procedure typically involves the insertion of two catheters: one transurethral or suprapubic into the bladder to measure intravesical pressure (P_ves) and infuse fluid, and a second into the rectum or vagina to measure abdominal pressure (P_abd).^[6] Detrusor pressure (P_det) is then calculated subtractively as P_det = P_ves - P_abd, which isolates the bladder's smooth muscle activity from external influences.^[31] The bladder is filled with warmed sterile saline or water at a controlled rate, commonly 10-50 mL/min, adjusted based on patient tolerance and clinical context to mimic physiological conditions or provoke responses.^[6] This multichannel setup uses electronic transducers connected to a computer system for real-time recording, ensuring at least 10 data points per second for accuracy.^[31] During filling, key assessments include patient-reported sensations such as first sensation of filling (typically at 100-200 mL), first desire to void, strong desire to void, and maximum cystometric capacity (around 400-600 mL in adults).^[6] Bladder compliance, defined as the change in volume per change in detrusor pressure (ΔV/ΔP_det), is a critical parameter reflecting the bladder's ability to store urine without excessive pressure rise; normal values exceed 30-40 mL/cm H₂O, with reduced compliance indicating potential risk for upper urinary tract damage.^[4] Involuntary detrusor contractions, if present, signify detrusor overactivity and may cause urgency or leakage, assessed by sudden rises in P_det during filling to strong desire or until leakage occurs.^[31] The test continues until the patient reaches a strong desire to void or experiences discomfort, providing insights into storage disorders like overactive bladder.^[6] Pressure-flow studies complement cystometry by evaluating voiding dynamics immediately after the filling phase, upon patient permission to void. This involves simultaneous measurement of P_det and urinary flow rate using the same catheter setup, with a flowmeter to record voided volume and maximum flow rate (Q_max).^[4] The detrusor pressure at Q_max (P_detQ_max) is a key metric; elevated values (e.g., >40 cm H₂O) combined with low Q_max (<10-15 mL/s) suggest bladder outlet obstruction, such as in benign prostatic hyperplasia, while low P_det indicates detrusor underactivity.^[6] These studies help differentiate causes of voiding dysfunction, guiding interventions like prostate surgery.^[31] According to AUA/SUFU guidelines, pressure-flow studies are recommended for men with lower urinary tract symptoms prior to invasive therapy to confirm obstruction (evidence strength: Grade B).^[4]

Electromyography and Urethral Pressure Profilometry

Electromyography (EMG) is a key component of urodynamic testing that evaluates the electrical activity of the external urethral sphincter and pelvic floor muscles to assess their coordination with bladder function.^[6] It employs either surface electrodes placed on the perianal skin or needle electrodes inserted into the external anal or urethral sphincter to record muscle potentials during bladder filling and voiding phases.^[32] Surface EMG is noninvasive and commonly used for routine screening, while needle EMG provides more precise single-fiber recordings but requires greater expertise due to its invasiveness.^[33] In normal physiology, the external urethral sphincter and pelvic floor muscles should relax during voluntary voiding to allow detrusor contraction without obstruction, resulting in a quiescent EMG tracing.^[31] Abnormal activity, such as involuntary contractions during detrusor contraction, indicates detrusor-sphincter dyssynergia (DSD), a condition prevalent in neurogenic bladder disorders like spinal cord injury. DSD is typically associated with suprasacral lesions and is less common in sacral or cauda equina injuries.^[34] EMG detects DSD by capturing these discordant sphincter bursts, aiding in the diagnosis of neurologically mediated outlet obstruction and guiding interventions to prevent complications such as vesicoureteral reflux.^[35] EMG is typically integrated with cystometry and pressure-flow studies, where it monitors sphincter behavior in real-time alongside bladder pressure measurements, though pressure subtraction techniques from cystometry are used separately to isolate detrusor activity.^[28] This combined approach enhances the identification of neuromuscular incoordination, particularly in patients with suprasacral spinal cord injuries, where DSD occurs in 70–100% of cases.^[36] Urethral pressure profilometry (UPP) measures the resistance along the urethra to evaluate sphincter competence and continence mechanisms.^[6] The procedure involves slowly withdrawing a catheter-based microtransducer or water-perfused system from the bladder through the urethra at a constant rate (typically 1 mm/s), generating a pressure profile that records variations in urethral closure pressure relative to intravesical pressure.^[37] Key parameters include the maximum urethral closure pressure (MUCP), which quantifies the highest pressure exerted by the sphincter at rest, and the functional profile length, representing the urethral segment where pressure exceeds bladder pressure to maintain continence.^[38] UPP assesses sphincter integrity, with low MUCP values indicating intrinsic sphincter deficiency, a common cause of stress urinary incontinence.^[6] In urodynamic protocols, it is often performed during rest, stress maneuvers like coughing, or pelvic floor contractions, and integrated with cystometry to correlate urethral function with bladder dynamics.^[38] For neurogenic conditions, such as spinal cord injury, UPP helps detect impaired sphincter relaxation contributing to DSD by showing persistent high pressures during voiding attempts.^[39] Despite its utility, UPP's reproducibility is limited, and guidelines recommend it selectively for complex cases rather than routine incontinence grading.^[4]

Video Urodynamics

Video urodynamics (VUD), also known as videourodynamic studies (VUDS), integrates synchronous fluoroscopic imaging with conventional urodynamic pressure measurements, such as cystometry and pressure-flow studies, to provide dynamic visualization of the lower urinary tract during bladder filling and voiding.^[4] This multimodal approach allows for the correlation of anatomical structures with functional data, enhancing diagnostic accuracy in cases where standard non-imaging urodynamics may be inconclusive.^[40] The procedure typically begins with the insertion of urethral and rectal catheters for pressure monitoring, followed by bladder filling with a contrast-infused saline solution at a controlled rate, often around 60 mL/min, while intermittent fluoroscopic images are captured to observe bladder and urethral dynamics.^[40] Imaging occurs at key moments, including rest, coughing, straining, filling phases, and voiding, to assess bladder neck position, urethral configuration, and potential abnormalities like vesicoureteral reflux (VUR) or diverticula formation.^[21] Patients are positioned in a natural sitting or standing posture on a radiolucent commode to facilitate realistic voiding conditions, with the entire study lasting 30-60 minutes.^[21] Indications for VUD are primarily reserved for complex clinical scenarios where anatomical abnormalities are suspected, such as in patients with neurogenic bladder dysfunction, persistent lower urinary tract symptoms despite initial treatments, or histories of pelvic surgery that may involve prolapse, urethral strictures, or fistulas.^[4] It is particularly valuable for evaluating conditions like detrusor-sphincter dyssynergia in neurological disorders (e.g., multiple sclerosis or spinal cord injury) or primary bladder neck obstruction, where visual confirmation of structural issues guides therapeutic decisions.^[40] Due to the added radiation exposure, VUD is not routine and is recommended only when the potential diagnostic benefits outweigh risks, such as in preoperative planning for incontinence surgery or assessment of post-void residual elevation.^[4] Emerging alternatives like contrast-enhanced voiding ultrasonography aim to provide similar insights without ionizing radiation, but VUD remains the gold standard for detailed anatomical-functional integration in select cases.^[41] The equipment for VUD includes a fluoroscopy unit—either a fixed X-ray system or mobile C-arm—coupled with standard urodynamic apparatus, such as dual-lumen catheters, pressure transducers, an infusion pump for contrast medium (typically iodinated contrast diluted in saline), and specialized software for synchronizing images with pressure tracings.^[21] A radiolucent toilet or commode is essential to allow unobstructed imaging during voiding, and electromyography electrodes may be added for brief functional assessment if needed.^[40] To minimize radiation, protocols emphasize pulsed low-dose fluoroscopy, tight collimation to the region of interest (e.g., bladder and urethra), and intermittent imaging rather than continuous screening, with total fluoroscopy time often limited to under 60 seconds.^[42] Key findings from VUD provide dynamic insights into leakage mechanisms and obstructions that are not discernible through pressure measurements alone, such as the real-time opening of the bladder neck, urethral kinking due to prolapse, or intermittent VUR during filling that could indicate upper tract risks.^[21] For instance, it can reveal diverticula as outpouchings on the bladder wall or strictures as narrowed urethral segments during voiding, correlating these visuals with pressure-flow data to differentiate between functional and anatomical causes of incontinence or retention.^[40] These observations are critical for tailoring interventions, such as sling placement or neuromodulation, by identifying issues like intrinsic sphincter deficiency or bladder outlet pathology.^[4] Radiation exposure in VUD is relatively low compared to other fluoroscopic procedures, with effective doses typically under 5 mSv per study—often around 0.1-0.5 mSv in adults—equivalent to a few months of natural background radiation, though efforts to optimize protocols are ongoing to further reduce doses, especially in pediatric or repeated testing scenarios.^[43] Factors influencing dose include patient body mass index, fluoroscopy duration, and equipment settings, with guidelines stressing informed consent and ALARA (as low as reasonably achievable) principles.^[42]

Interpretation and Clinical Application

Normal Values

Normal urodynamic testing establishes baseline reference ranges for bladder and urethral function, aiding in the differentiation of physiological variations from pathological states. Key bladder parameters include cystometric capacity, typically ranging from 300 to 600 mL in adults, with males exhibiting slightly higher volumes (300–600 mL) compared to females (300–500 mL).^[6] Bladder compliance, defined as the change in volume per unit change in detrusor pressure, is considered normal at greater than 40 mL/cm H₂O in non-neurogenic conditions and greater than 30 mL/cm H₂O in neurogenic bladders.^[6] First sensation of bladder filling occurs at volumes of 50–200 mL, reflecting the onset of awareness during cystometry.^[40] Uroflowmetry provides essential flow metrics, with maximum flow rate (Qmax) normally between 15 and 25 mL/s, adjusted for age and sex: greater than 20 mL/s in young adult males and greater than 18 mL/s in young adult females.^[6] Post-void residual (PVR) volume is typically less than 50 mL, indicating efficient bladder emptying.^[44] Pressure measurements during testing include resting detrusor pressure (Pdet), which ranges from -5 to +5 cm H₂O at baseline.^[6] Maximum urethral closure pressure (MUCP) exceeds 20 cm H₂O in continent adults, serving as a threshold for urethral competency.^[45] Variations in these parameters occur with age and sex. Qmax declines progressively with age, approximately 2–3 mL/s per decade after age 40 in men, due to reduced detrusor contractility and outlet resistance.^[46] Bladder capacity shows sex differences, with males generally having higher volumes attributable to anatomical factors like prostate size.^[6] These ranges align with International Continence Society (ICS) standards for good urodynamic practices, emphasizing adjustments for neurogenic versus non-neurogenic conditions to ensure accurate interpretation.^[28]

Abnormal Findings and Diagnosis

Urodynamic testing identifies abnormal findings by detecting deviations in bladder pressure, flow rates, and coordination during filling and voiding phases, enabling precise diagnoses of lower urinary tract dysfunction. Common abnormalities include detrusor overactivity, characterized by involuntary detrusor contractions exceeding 15 cm H₂O during the filling phase, which often correlates with urgency urinary incontinence and overactive bladder syndrome.^[4] Stress urinary incontinence is diagnosed when involuntary leakage occurs during increased abdominal pressure, such as coughing, without detrusor contraction, typically with an abdominal leak point pressure below 60 cm H₂O indicating intrinsic sphincter deficiency.^[47] Bladder outlet obstruction is evident in pressure-flow studies showing elevated detrusor pressure at maximum flow (PdetQmax >40 cm H₂O in men) alongside reduced maximum flow rate (Qmax <10-15 ml/s), often plotted on the Blaivas-Griffiths nomogram to confirm obstruction, particularly in men with benign prostatic hyperplasia.^[6] Diagnostic patterns further refine these assessments; for instance, detrusor underactivity manifests as low detrusor pressure (<10 cm H₂O) during voiding with incomplete bladder emptying and elevated post-void residual volume, commonly seen in neurogenic or myogenic conditions affecting 40% of men with lower urinary tract symptoms.^[4] Detrusor sphincter dyssynergia, a neurogenic disorder, is identified by electromyography revealing involuntary external sphincter activity during detrusor contraction, leading to obstructed voiding and high intravesical pressures, prevalent in up to 95% of spinal cord injury patients.^[6] Low bladder compliance, defined as less than 10 ml/cm H₂O in neurogenic cases, indicates poor detrusor accommodation during filling, resulting in sustained high pressures that risk upper urinary tract damage such as hydronephrosis.^[6] Clinical correlation integrates these urodynamic abnormalities with patient symptoms and history; for example, detrusor overactivity confirmed during cystometry alongside urgency symptoms supports a diagnosis of idiopathic overactive bladder, while stress incontinence findings in a patient with leakage during physical activity guide evaluation for intrinsic sphincter deficiency.^[4] Similarly, bladder outlet obstruction patterns must align with obstructive symptoms like weak stream to differentiate from detrusor underactivity, ensuring accurate etiology.^[6] These findings predict treatment outcomes and direct therapy; detrusor overactivity prompts anticholinergic medications or botulinum toxin injections to reduce involuntary contractions, with success rates up to 70% in symptom relief.^[6] Bladder outlet obstruction confirmed urodynamically supports surgical interventions like transurethral resection of the prostate, improving flow in 80-90% of cases, whereas detrusor underactivity may necessitate clean intermittent catheterization to manage retention risks.^[4] Dyssynergia and low compliance often require aggressive management, such as sacral neuromodulation or augmentation cystoplasty, to prevent renal complications.^[6]

Standardization and Guidelines

Standardization Efforts

The International Continence Society (ICS) has played a central role in standardizing urodynamic testing through its Good Urodynamic Practices (GUP) document, first updated in 2016 as an evidence-based revision of the 2002 version, with ongoing refinements via subsequent working groups and educational modules.^[28] This framework defines over 30 terms more precisely and establishes standards for practice, quality control, interpretation, and documentation to ensure consistency across global clinical and research settings.^[28] Key elements include recommendations for filling rates during cystometry, such as a physiological rate of 20–30 mL/min or a non-physiological rate equivalent to 10% of the patient's typical voided volume from a bladder diary, adjusted for post-void residual.^[48] Pressure measurements are standardized using fluid-filled catheters connected to external transducers positioned at the level of the pubic symphysis, with protocols emphasizing regular equipment calibration to minimize artifacts.^[48] Reporting formats specify the use of ICS-standard graphs for urodynamic traces and pressure-flow plots, alongside a structured template for summarizing findings to facilitate comparable data across studies.^[48] These efforts address key challenges in methodological variability, such as differences in voiding positions, where sitting versus standing can significantly influence maximum flow rate (Qmax), with studies reporting improvements of up to 20% in sitting positions for men with lower urinary tract symptoms, potentially altering diagnostic interpretations.^[49] Equipment calibration protocols mitigate inconsistencies from transducer drift or catheter positioning, requiring pre-test zeroing and periodic verification against known pressures to enhance measurement reliability.^[48] Technological advances have supported standardization through the integration of digital software for automated calculations, enabling real-time quality checks for artifacts like straining or detrusor overactivity and improving data pattern recognition during tests.^[48] International workshops, particularly at ICS annual meetings since 2020, have fostered these developments via interactive sessions on equipment setup, troubleshooting, and adherence to GUP guidelines, incorporating feedback to refine practices.^[50] Post-2016 updates, including joint ICS-SUFU standards in 2023, continue to evolve these tools for pressure-flow analysis.^[51] Outcomes of these standardization initiatives include enhanced reproducibility of urodynamic results, with studies demonstrating high test-retest reliability for key metrics, and reduced inter-observer variability in diagnosing bladder outlet obstruction using the Abrams-Griffiths number (now bladder outlet obstruction index, BOOI = PdetQmax - 2 × Qmax).^[52]^[28]

Current Guidelines

The American Urological Association (AUA) and Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) 2014 guideline on adult urodynamics recommends multichannel urodynamic testing as an option for evaluating stress urinary incontinence in patients considering invasive therapy, particularly to assess urethral function and occult incontinence.^[4] It establishes complex cystometry and pressure-flow studies as recommendations for initial evaluation of neurogenic lower urinary tract symptoms (LUTS), including in conditions like multiple sclerosis or spinal cord injury, to identify detrusor overactivity or underactivity.^[4] For benign prostatic hyperplasia (BPH) or non-neurogenic LUTS, the guideline conditionally supports pressure-flow studies as a standard to confirm bladder outlet obstruction prior to invasive treatments, while post-void residual measurement and uroflowmetry serve as initial safety assessments.^[4] The 2024 AUA/SUFU overactive bladder (OAB) guideline amends these by advising against routine urodynamics in initial OAB evaluations but permitting it in patients unresponsive to pharmacotherapy or minimally invasive therapies to assess bladder function and exclude alternative disorders.^[53] The International Continence Society (ICS) 2016 Good Urodynamic Practices (GUP) emphasize patient-centered approaches, such as conducting uroflowmetry in the patient's preferred voiding position for representativeness and providing pre-test information leaflets to reduce anxiety and enhance understanding.^[48] To avoid overuse, it prioritizes non-invasive tests like uroflowmetry and post-void residual measurement before invasive procedures in straightforward cases, reserving multichannel studies for when initial assessments are inadequate or unrepresentative.^[48] Subsequent 2023 ICS-SUFU standards on pressure-flow studies reinforce selective application, recommending video urodynamics only when anatomical evaluation is needed to differentiate voiding dysfunction, rather than routinely.^[54] The European Association of Urology (EAU) 2023 guidelines on non-neurogenic female LUTS align with these by strongly recommending against routine urodynamics for first-line treatment of uncomplicated OAB, citing level 1a evidence from a Cochrane review of seven randomized controlled trials showing no impact on clinical outcomes despite influencing treatment choices like pharmacotherapy.^[55] The Choosing Wisely campaign, through AUA recommendations from 2015, advises against urodynamic testing in uncomplicated urgency urinary incontinence prior to conservative management, to reduce unnecessary invasive procedures without altering outcomes. Emerging directions include integrating artificial intelligence for automated interpretation of urodynamic traces to improve diagnostic precision and reduce interobserver variability, as explored in 2024 studies evaluating AI models for pattern recognition in cystometry data.^[56] The 2024 AUA/SUFU OAB guideline further stresses shared decision-making, urging clinicians to collaborate with patients on testing and treatment options based on individual preferences, values, and goals to optimize adherence and outcomes.^[53]

References

[1]
Urodynamic Testing - NIDDK
Urodynamic tests help diagnose lower urinary tract problems by showing how well your bladder, sphincters, and urethra work together to store and release ...What is urodynamic testing? · What urodynamic tests do...
[2]
Urodynamic Testing: Purpose, Procedure, Risks & Results
Urodynamic testing helps diagnose conditions that affect your bladder, urinary sphincter and urethra. They're safe and relatively simple tests that can give ...
[3]
What is Urodynamics? - Urology Care Foundation
Urodynamic studies (UDS) test how well the bladder, sphincters, and urethra hold and release urine. These tests can show how well the bladder works.
[4]
Urodynamic Testing and Interpretation - StatPearls - NCBI Bookshelf
Urethral Pressure Profile provides the measurement of the urethral length and its competence. It is typically performed in women to help determine the cause of ...
[5]
[PDF] AUA/SUFU Guideline - American Urological Association
Urodynamics (UDS) is the dynamic study of the transport, storage and evacuation of urine. UDS is an interactive diagnostic study of the lower urinary tract ...
[6]
Simultaneous recording of intravesical and intra-urethral pressure. A ...
Simultaneous recording of intravesical and intra-urethral pressure. A study on urethral closure in normal and stress incontinent women.
[7]
The uroflometer; an aid to the study of the lower urinary tract - PubMed
The uroflometer; an aid to the study of the lower urinary tract. J Urol. 1948 Apr;59(4):650-8. doi: 10.1016/S0022-5347(17)69425-4.Missing: uroflowmeter | Show results with:uroflowmeter
[8]
[PDF] THE HISTORY OF URODYNAMICS - OSTI.gov
It was at this meeting that many of the participants were first informed of the unique laboratory of Earl. R. Miller with the combination of cystometry, ...
[9]
SYNCHRONOUS CINE/PRESSURE/FLOW/CYSTO ...
REFERENCES. Bates@, C. P. and Cornery@, C. E., (1970). Synchorous cine/pressure/flow cystography; a method of routine urodynamic investigation. British Jounal ...
[10]
Urge Incontinence and Unstable Bladder First Report on the ...
Produced by the International Continence Society Committee for Standardization of. Terminology, Aachen, February 1975. Introduction. This report contains the ...
[11]
Urodynamic Studies | Abdominal Key
Jun 14, 2016 · ... 1960s, the principles of hydrodynamics were applied to lower urinary tract physiology. In the 1970s, videourodynamic was introduced, where ...
[12]
Video Urodynamics in the Digital Age: What Have We Overlooked?
Mar 31, 2023 · A urodynamic study is an important test that helps clinicians objectively evaluate a patient's subjective voiding symptoms and decide on the ...
[13]
Victor Fray Marshall: Twentieth Century Renaissance Urologist
Purpose: Victor Fray Marshall (1913 to 2001) contributed to advancements in a variety of fields within urology, including incontinence, oncology, ...Missing: uroflowmetry | Show results with:uroflowmetry
[14]
[PDF] s Continence Society standardization report on urodynamic studies ...
May 21, 2015 · Indications for invasive UDS in non-neurogenic conditions include: voiding frequency 3 per day, straining or manual expression during voiding, ...
[15]
The AUA/SUFU Guideline on the Diagnosis and Treatment of ...
Apr 23, 2024 · The purpose of this guideline is to provide a clinical framework for the diagnosis and treatment of idiopathic non-neurogenic overactive bladder.
[16]
Don't perform cystoscopy, urodynamics or diagnostic renal and ...
Don't perform cystoscopy, urodynamics or diagnostic renal and bladder ultrasound in the initial work-up of an uncomplicated overactive bladder patient.
[17]
Urodynamic testing - Bumrungrad International Hospital
Feb 5, 2024 · What are the contraindications for urodynamic testing? Any patient able to comply with instructions can get urodynamic testing, except those ...Missing: absolute | Show results with:absolute
[18]
[PDF] Urodynamics - RACGP
Urodynamics is the study of lower urinary tract function and how this relates to a patient's urinary symptoms. The aim is to reproduce the patient's lower ...
[19]
Best practice for Videourodynamics: A teaching module of the ...
Patient refusal for radiation, contrast or iodine allergy are absolute contraindications for VUD. Cognitive impairment, impaired renal function, balance ...
[20]
Where can urodynamic testing help assess male lower urinary tract ...
Urodynamic testing. The term “urodynamics” was defined as the assessment of the function and dysfunction of the urinary tract by any appropriate method.
[21]
ICS 2024 Abstract #728 Incidence of Urinary Tract Infection Post ...
Oct 25, 2024 · The overall incidence of UTI post-VCMG in 2017 was 4.44% and this has decreased to 3% in 2023. The highest incidence of UTI post VCMG was in the sheath ...
[22]
Urinary Tract Infections in Patients Undergoing Invasive Urodynamic ...
Jan 23, 2024 · It appears that invasive urodynamic testing has a low risk of UTI, and monitoring for UTI was not necessary after UDS. Additionally, ...
[23]
EAU Guidelines on the Management of Non-neurogenic Male LUTS
The International Prostate Symptom Score (IPSS). The IPSS is an eight-item questionnaire, consisting of seven symptom questions and one QoL question [26]. The ...
[24]
[PDF] Joint statement on minimum standards for urodynamic practice in ...
At least 200 studies per annum should be performed within the department to maintain ... test and the need to stop certain medications, e.g. anticholinergics. You ...
[25]
Standard operating procedure for urodynamics - NCBI - NIH
The UDS should be performed with aseptic precautions, counselling and verbal consent and according to the Good Urodynamics Practice Guidelines.
[26]
International Continence Society Good Urodynamic Practices and ...
Dec 5, 2016 · Video urodynamics is not further discussed in this document. 3 PATIENT INFORMATION AND PREPARATION OF THE PATIENT FOR INVASIVE URODYNAMICS. 3.1 ...
[27]
Best practice policy statement on urodynamic antibiotic prophylaxis ...
Abstract. Aims: Antibiotic prophylaxis before urodynamic testing (UDS) is widely utilized to prevent urinary tract infection (UTI) with only limited guidance.
[28]
Bladder Post Void Residual Volume - StatPearls - NCBI Bookshelf
Post-void residual volume (PVR) is the amount of urine retained in the bladder after a voluntary void and functions as a diagnostic tool.Missing: uroflowmetry | Show results with:uroflowmetry
[29]
[PDF] Chapter 7 - Urodynamics - International Continence Society
Cystometry with or without simultaneous imaging, ambulatory urodynamics and the measurement of leak point pressures are the primary examples of such tests.
[30]
[PDF] ICS Teaching Module: Electromyography in the assessment and ...
Electromyography in the assessment and therapy of lower urinary tract dysfunction in adults. Dr. Ömer Gülpınar. Page 3. Teaching Module. Principle of EMG.
[31]
Detrusor sphincter dyssynergia: a review of physiology, diagnosis ...
Detrusor sphincter dyssynergia (DSD) is the urodynamic description of this neurologically induced bladder outlet obstruction.
[32]
Bladder Sphincter Dyssynergia - StatPearls - NCBI Bookshelf - NIH
Nov 12, 2023 · A condition that causes lower urinary tract symptoms in patients with spinal cord injuries and neurological disorders.
[33]
Experience with Electromyography of the External Urethral ...
This detrusor-sphincter dyssynergia was found in 67 per cent of our patients regardless of the differences in cystometric patterns and the level of spinal ...
[34]
Urethral pressure profilometry | International Urogynecology Journal
Urethral pressure profilometry has gained widespread usage in the diagnosis and clinical investigation of those patients with incontinence.Missing: testing | Show results with:testing
[35]
Assessing the Role of Urethral Pressure Profilometry (UPP ... - IUGA
Profiles can be measured at rest, under stress (cough test / Valsalva), during pelvic floor contractions or even during the voiding phase.
[36]
Urethral Pressure Measurement as a Tool for the Urodynamic ...
Dec 31, 2018 · To describe a technique for urodynamic diagnosis of detrusor sphincter dyssynergia (DSD) using urethral pressure measurements.<|control11|><|separator|>
[37]
Urodynamic Studies for Urinary Incontinence - Medscape Reference
Aug 10, 2023 · Urodynamics are a means of evaluating the pressure-flow relationship between the bladder and the urethra for the purpose of defining the functional status of ...Performing Urodynamic... · Cystometry Or... · Uroflowmetry And Leak-Point...<|separator|>
[38]
Considerations for Videourodynamics and How it Impacts Practice
Aug 5, 2025 · Although the typical radiation exposure during VUDS is relatively low compared to other fluoroscopic procedures, following a standardized ...
[39]
ICS 2019 Abstract #521 Radiation Exposure in Video Urodynamics
Sep 6, 2019 · Video urodynamics utilises fluoroscopy to provide diagnostic evaluation of patients with lower urinary tract dysfunction. However, exposure to radiation is an ...Missing: indications key findings
[40]
Effective and Organ Specific Radiation Doses from ...
The findings from the present study may be helpful in counseling families regarding the amount of radiation dose expected from a video-urodynamic study.Missing: key | Show results with:key
[41]
Postvoid Residual Urine Volume - an overview | ScienceDirect Topics
Postvoid residual urine volumes refer to the amount of urine remaining in the bladder after voiding, with less than 50 mL considered normal and 200 mL or ...
[42]
[PDF] maximum urethral closure pressure in continent and incontinent ...
MUCP ≤20 cm H2O was found in 5.8% of women with. USI, 3.8% of women with USI+DOI, 2.2% of women with DOI alone, and 1.4% of normal continent women. MUCP ≤20 cm ...
[43]
[PDF] Evaluation of urodynamics parameters in different age and ...
Nov 19, 2020 · In the uroflowmetry, maximal flow rate (Qmax), time to Qmax, voided volume, PVR, and filling cystometry data including first, strong desire to ...
[44]
[PDF] Urodynamics, uroflowmetry, cystometry, and pressure-flow study
May 13, 2016 · The ICS Standardisation WG has updated the International. Continence Society's Good Urodynamic Practice standard. This evidence-based ICS ...
[45]
Urinating Standing versus Sitting: Position Is of Influence in Men with ...
We found that in patients with LUTS the sitting position is associated with a trend towards a more favorable urodynamic profile: Qmax is increased, PVR is ...Missing: variability | Show results with:variability
[46]
ICS 2020 Workshop 26 - Basic Urodynamics - An Interactive Workshop
Learn how to set up urodynamic equipment. Learn how to run a test and troubleshoot according to good practice guidelines. Learn how to interpret urodynamic ...Missing: annual meetings post-
[47]
ICS-SUFU standard: Theory, terms, and recommendations for ...
A pressure flow study is the gold standard to assess voiding function and to quantify dysfunction. This part of the standard explains the clinical background.
[48]
The Immediate and 6-mo Reproducibility of Pressure–Flow Studies ...
Urodynamics has good reproducibility when looking at the BOOI and BCI, indicating that a second study is not necessary in most patients.
[49]
None
Summary of each segment:
[50]
ICS‐SUFU standard: Theory, terms, and recommendations for ...
May 4, 2023 · The WG has recommended analysis principles for the diagnosis of voiding dysfunction for adult men and women without relevant neurological abnormalities.<|separator|>
[51]
EAU Guidelines on Non-neurogenic Female LUTS - DISEASE ...
Most studies on anticholinergic medication are short term (twelve weeks). ... Perform urodynamic tests if the findings may change the choice of invasive treatment ...Missing: hold | Show results with:hold
[52]
Envisioning the Future of AI in Urodynamics: Exploratory Interviews ...
Ten semi‐structured interviews were conducted to explore expectations, trust and possibilities of AI in urodynamics. Content analysis with an inductive approach ...