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Infusion

Infusion is a process of extracting flavors, aromas, or active compounds from solid ingredients—typically herbs, spices, fruits, or other plant materials—by steeping them in a liquid solvent, such as water, oil, alcohol, or vinegar.^[1] This method allows soluble substances to diffuse into the liquid without boiling the source material, producing beverages like herbal teas (tisanes), flavored oils, or medicinal extracts, and is distinct from decoction, which involves simmering.^[2] Unlike more intensive extraction techniques, infusion relies on gentle soaking, often with heat, to preserve delicate volatiles. The practice has ancient origins, with herbal infusions used for therapeutic and culinary purposes in China as early as 2737 BCE, according to legend, and documented in Egyptian medical texts around 1550 BCE.^[3] It spread globally through trade routes, evolving in modern times (19th–20th centuries) with innovations like tea bags (invented 1908) and commercial production for consistent quality, while traditional methods persist in home and artisanal settings.^[4] Infusions are applied in culinary contexts to enhance dishes and drinks, and in medicinal traditions to deliver plant-based remedies for conditions like digestion or relaxation, though efficacy varies and potential risks include allergic reactions or microbial contamination if hygiene is poor.^[5] Procedures typically last 5–15 minutes for hot water methods, with benefits including simplicity, cost-effectiveness, and preservation of heat-sensitive compounds, as of 2025.^[6]

Definition and Principles

Core Concept

Infusion is a process of extracting soluble compounds, such as flavors, essential oils, and alkaloids, from plant material by steeping it in a solvent like water, oil, or alcohol, without boiling the material itself.^[7] This method relies on the natural solubility of these compounds in the chosen solvent, allowing them to diffuse passively into the liquid over time.^[8] Typically performed at temperatures below the boiling point to preserve heat-sensitive volatile components, the steeping duration ranges from minutes to hours, depending on the solvent, plant material, and desired extraction yield.^[9] Key characteristics of infusion include its simplicity and gentleness, making it suitable for delicate plant parts like leaves and flowers where thermolabile constituents are present.^[7] Unlike decoction, which involves boiling the plant material to extract tougher, heat-stable compounds, infusion uses milder conditions such as hot water poured over the material or cold solvents to avoid degradation.^[8] It also differs from maceration, a longer soaking process often lasting days at room temperature with occasional agitation, whereas infusion emphasizes shorter contact times for quicker release of readily soluble substances.^[9] In contrast to other extraction techniques, infusion depends on solvent immersion and diffusion rather than mechanical or thermal extremes; for instance, it avoids the vapor-based separation of distillation, which targets volatile oils through heating and condensation, or the physical pressing of expression, used to mechanically release juices from fruits like citrus.^[8] The basic process begins with selecting and preparing the plant material, often by grinding or chopping it to increase surface area, followed by choosing an appropriate solvent based on the target compounds' solubility.^[7] The material is then steeped under controlled conditions—such as temperature and time—to facilitate extraction, and finally strained to separate the infused liquid from the solids.^[9]

Scientific Basis

Infusion relies on fundamental principles of solubility, where the solvent's polarity determines the types of compounds extracted from the plant matrix. Polar solvents like water effectively dissolve hydrophilic compounds, such as tannins and polyphenols, due to favorable interactions between the solvent's dipole and the solute's polar groups.^[7] In contrast, non-polar solvents like oils are used to extract lipophilic compounds, including essential oils and terpenes, which are poorly soluble in water but dissolve readily in lipid media through van der Waals forces.^[7] This selectivity arises from the "like dissolves like" rule, ensuring that the solvent matches the solute's chemical nature to maximize extraction efficiency.^[10] The movement of solutes during infusion is governed by diffusion, primarily described by Fick's laws, which quantify the transport from the high-concentration plant material to the lower-concentration solvent. Fick's first law states that the diffusive flux J is proportional to the concentration gradient:

J = -D \frac{\partial c}{\partial x}

where D is the diffusion coefficient, c is the concentration, and x is the position.^[11] Fick's second law extends this to time-dependent changes in concentration, modeling the unsteady-state diffusion process in infusions like tea, where solute release follows a non-linear decay.^[11] Key factors influencing this process include surface area of the plant material (increasing contact enhances gradient steepness), temperature (which raises D by accelerating molecular motion), and infusion time (longer durations approach equilibrium but risk compound degradation).^[12] Osmosis plays a secondary role in initial swelling of plant cells, facilitating solute release, but diffusion dominates the overall extraction kinetics.^[12] Commonly extracted compounds in infusions include flavonoids and polyphenols, which are hydrophilic and yield antioxidants in water-based preparations, and terpenes, which require non-polar solvents for efficient recovery due to their volatility and hydrophobicity.^[10] These compounds' stability varies: flavonoids remain intact between pH 5 and 7 but degrade above pH 8, while polyphenols exhibit higher extraction yields at lower pH values (e.g., pH 2 increases catechin recovery by stabilizing against oxidation).^[13] Terpenes, being more sensitive to heat and oxidation, show reduced stability in aqueous infusions, often requiring cooler conditions to preserve aroma profiles.^[14] pH adjustments thus optimize yield and quality, as acidic environments enhance polyphenol solubility without excessive breakdown.^[15] Extraction efficiency is quantified by yield metrics, such as the percentage of solute extracted, calculated as:

\text{Yield (\%)} = \left( \frac{\text{mass of solute in solvent}}{\text{total mass of solute in material}} \right) \times 100

This formula assesses completeness, with typical yields for polyphenols in herbal infusions ranging from 50-90% under optimized conditions, influenced by solvent ratio and agitation.^[10] Overall yields (mass of total extract per dry plant mass) provide broader efficiency indicators, emphasizing the balance between diffusion rates and compound stability.^[16]

Historical Development

Ancient Origins

Archaeological evidence indicates that prehistoric humans in the Near East and East Asia utilized plant materials in steeped preparations as early as the Neolithic period. In the Shanidar Cave site in modern-day Iraq, residues of yarrow (Achillea millefolium) and marshmallow (Althaea spp.) were found associated with Neanderthal burials dating back approximately 60,000 years, suggesting medicinal use possibly involving infusions for healing or ritual purposes.^[17] Similarly, at the Jiahu site in Henan Province, China, around 7000–6600 BCE, chemical analyses of pottery residues revealed a fermented beverage incorporating hawthorn fruit and other herbal elements alongside rice and honey, representing one of the earliest known instances of steeped plant extracts in a vessel.^[18] In early civilizations, infusions played a central role in medical and preservation practices. Chamomile (Matricaria chamomilla) was used in ancient Egyptian medicine for various ailments, including fevers and inflammation.^[19] Greek physician Hippocrates (c. 460–370 BCE) prescribed herbal remedies, including mint, and chamomile appears in his corpus for use as infusions or poultices to alleviate symptoms of illness.^[20] Roman herbalist Pedanius Dioscorides, in his influential work De Materia Medica (c. 50–70 CE), cataloged over 600 plants, including fennel and verbena, with descriptions of their medicinal preparations for applications ranging from pain relief to wound care. Asian traditions trace the origins of infusion practices to legendary and textual sources. In China, the Shennong legend, dated to around 2737 BCE, attributes the discovery of tea infusion to the emperor boiling water under a Camellia sinensis tree, leading to its use as a medicinal brew for detoxification and vitality, as recorded in later classical texts like the Shennong Bencao Jing.^[21] In India, Ayurvedic texts such as the Charaka Samhita (c. 1000–300 BCE) describe kashaya or herbal decoctions—boiled infusions of plants like ginger and tulsi—for balancing doshas and treating imbalances, distinguishing gentler infusions from stronger boils while integrating them into daily health regimens.^[22] Infusions held profound cultural significance in rituals across indigenous societies. Among Native American tribes, such as the Lakota and Navajo, sweat lodge ceremonies involved pouring water over heated rocks adorned with herbs like sage (Salvia apiana) and cedar (Thuja spp.) to create aromatic steam infusions, believed to purify the body and spirit while invoking healing and communal bonding.^[23] In various African traditions, ancient medicinal brews from herbs were prepared through steeping for rituals in sub-Saharan communities, as evidenced in ethnographic records, where they facilitated divination, ancestor communication, and therapeutic rites dating back to prehistoric oral traditions.

Modern Evolution

During the Renaissance and Enlightenment periods, European apothecaries played a pivotal role in formalizing infusion recipes within comprehensive herbals, drawing on classical texts while incorporating empirical observations from practice. Nicholas Culpeper's Complete Herbal (1653), a seminal work by the English apothecary and physician, detailed preparations such as infusions and decoctions from over 400 plants, emphasizing their therapeutic uses for ailments like fevers and digestive issues.^[24] These formalized recipes reflected a shift toward systematic documentation, influenced by apothecaries' guild standards in cities like London and Florence, where testing for ingredient authenticity became routine.^[25] The spread of these infusion practices accelerated through European trade routes, as colonial expeditions introduced exotic herbs from Asia, Africa, and the Americas into European pharmacopeias, enriching local traditions with global botanicals. By the Enlightenment, works like those in the London Pharmacopoeia (1618, revised editions) integrated these imports, standardizing infusion methods for consistency in medicinal application across apothecary shops.^[26] In the 19th and early 20th centuries, industrialization transformed infusion from artisanal craft to mass production, with innovations like the accidental invention of the tea bag in 1908 by American merchant Thomas Sullivan, who sent silk pouch samples that customers steeped directly, sparking commercial viability.^[27] German company Teekanne advanced this in 1929 with a patented packing machine for paper bags, enabling widespread distribution.^[28] Concurrently, the rise of metal infusers—such as silver tea balls popular in Victorian Britain—facilitated home use, while post-World War II economic recovery fueled the commercialization of herbal teas, with packaged blends gaining popularity amid growing health consciousness and global supply chains.^[29]^[30] The 21st century has seen infusion evolve toward sustainability and innovation, with trends emphasizing organic certifications and ethical sourcing to address environmental concerns in herbal production.^[31] Globalization has fostered hybrid traditions, such as the adaptation of Japanese matcha infusions into Western wellness routines and fusion beverages, blending ancient rituals with modern palates.^[32] In mixology, infusions have resurged since the late 20th century, with bartenders using herbal extracts to create complex, spirit-based cocktails that highlight botanical flavors.^[33] Regulatory milestones have further shaped modern practices, notably the U.S. Dietary Supplement Health and Education Act (DSHEA) of 1994, which classified herbal infusions as dietary supplements when marketed for nutritional support, shifting oversight from pre-market approval to post-market safety monitoring by the FDA.^[34] Internationally, pharmacopeias like the European Pharmacopoeia have standardized infusion preparations, specifying extraction parameters, quality controls, and microbial limits to ensure reproducibility and safety in medicinal use.

Preparation Methods

Hot Water Infusion

Hot water infusion is a widely used method for extracting soluble compounds from plant materials, particularly dried leaves and herbs, by steeping them in heated water to produce beverages such as tea. The standard procedure involves heating water to a temperature between 80°C and 100°C, pouring it over the plant material at a ratio of approximately 1 teaspoon (2-3 grams) per 8 ounces (240 ml) of water, and allowing it to steep for 3 to 10 minutes, depending on the type of plant.^[35] Optimal temperatures vary to balance extraction efficiency and flavor preservation; for instance, green tea is best infused at 70-80°C to extract catechins without promoting bitterness from over-extraction of tannins, while black tea benefits from near-boiling water at 95-100°C for fuller flavor development.^[36] Steeping times are typically shorter for delicate leaves, such as 2-3 minutes for green tea, and longer for robust ones, up to 5 minutes for black tea, to achieve desired strength without compromising quality.^[37] Common equipment for hot water infusion includes teapots made of ceramic or glass to maintain consistent temperature, along with strainers or mesh infusers to separate the plant material after steeping. Stainless steel or silicone infusers are preferred for their durability and ease of cleaning, allowing for loose-leaf preparations without sediment. Variations such as a French press can be used for larger batches, where the plunger separates the leaves after infusion, providing an alternative to traditional strainers for controlling extraction.^[36] Several factors influence the quality of the resulting infusion. Water hardness, determined by mineral content like calcium and magnesium, can dull the color and alter the taste if excessively high, as bicarbonates bind to polyphenols and reduce clarity. Plant particle size affects extraction rate; finer particles release compounds more quickly, potentially leading to stronger brews, while coarser leaves promote gradual infusion for smoother results. Over-steeping poses a risk by increasing tannin extraction, which imparts astringency and bitterness due to the drying sensation caused by polyphenols binding to salivary proteins.^[36]^[38] Safety considerations emphasize avoiding direct boiling of the plant material in the water, as this can degrade heat-sensitive volatile compounds responsible for aroma and degrade delicate antioxidants like catechins in green teas. Instead, the method relies on pouring pre-heated water over the material to gently swell plant cells and release solubles without excessive heat exposure, preserving nutritional integrity.^[5]^[39]

Cold and Alternative Solvents

Cold water infusion, also known as cold steeping, involves submerging herbs, tea leaves, or other plant materials in room-temperature or chilled water for 4 to 24 hours to gently extract soluble compounds without applying heat. This technique is ideal for preparing iced teas or infusing delicate botanicals, such as white tea or rooibos, where prolonged exposure allows gradual diffusion of flavors and nutrients.^[40]^[41] A primary advantage of cold infusion lies in its ability to minimize oxidation and thermal degradation of heat-sensitive antioxidants, resulting in higher retention of polyphenols and enhanced overall antioxidant activity compared to hot methods. For example, cold-brewed rooibos exhibits a distinct phenolic profile by preserving heat-sensitive compounds, while white tea shows significantly boosted antioxidant levels after extended steeping. This preservation supports the method's use for maintaining the integrity of volatile and bioactive elements in sensitive herbs.^[41]^[42] Oil infusions extract lipophilic compounds from plant materials using carrier oils like olive or almond oil, typically through low-heat warming or sun-steeping to promote solubility while avoiding excessive temperatures that could compromise quality. In low-heat processes, the mixture is heated to 140°F (60°C) for 5 minutes, whereas sun-steeping relies on ambient sunlight over 1-2 weeks to facilitate a slower extraction, often with dried herbs to reduce moisture-related risks. These approaches are commonly applied to ingredients like garlic or rosemary in olive oil, ensuring safe preservation when using acidified fresh materials.^[43] Antioxidants from the infused plants, such as phenolics, play a crucial role in extending shelf life by inhibiting oxidative rancidity in the carrier oil, with studies showing that initial antioxidant content improves oxidative stability during storage, with phenolic levels decreasing over time but maintaining low peroxide values (below 7 mmol O₂/kg) for enhanced shelf life. For instance, herb-infused oils demonstrate improved stability after months of storage, allowing usability for 3-6 months or longer depending on the oil type and conditions like refrigeration. This natural protection is particularly effective in oils rich in tocopherols, reducing peroxide formation and maintaining sensory qualities.^[44] Alcohol tinctures utilize high-proof ethanol (40-95% alcohol by volume) as a versatile solvent to draw out both hydrophilic and lipophilic compounds from botanicals, enabling long-term preservation through alcohol's preservative and extraction efficiency. The process involves macerating chopped plant material in the alcohol for 2-6 weeks, with agitation to enhance diffusion, and is suited for roots, barks, or resins containing non-water-soluble actives. Standard ratios, such as 1:5 (herb to solvent by weight), optimize yield and concentration for medicinal or flavor applications, as this proportion balances extraction potency with solubility.^[7]^[45]^[46] For alcohol-free alternatives, glycerin serves as a sweet, humectant solvent in glycerites, where herbs are steeped in 60-95% vegetable glycerin (diluted with water if needed) for 1-2 weeks at room temperature, followed by straining. This method extracts water-soluble constituents effectively and yields stable products with a shelf life of 1-2 years when at least 55% glycerin is used, stored in airtight containers in a cool, dark place to prevent microbial growth and oxidation. Glycerites are particularly valued for their palatability in pediatric or sensitive formulations.^[47]^[48] Vinegar infusions employ acidic vinegars (e.g., apple cider or white wine vinegar at 5% acidity) to extract flavors and compounds from herbs, fruits, or spices over 2-4 weeks, creating culinary vinegars that enhance dressings or marinades. The process requires glass containers to avoid reactions, with daily shaking to aid extraction, and results in products preserved by the vinegar's low pH. Storage in dark bottles protects light-sensitive extracts from degradation, maintaining quality for up to three months in a cool, dark location at 50-70°F.^[49]^[50]

Applications and Uses

Culinary Applications

In culinary applications, infusion serves as a fundamental technique for extracting and incorporating flavors from herbs, fruits, spices, and other botanicals into beverages, enhancing their aromatic profiles without overpowering the base liquid. Herbal teas, prepared by steeping dried or fresh leaves in hot water, exemplify this method, where volatile oils and soluble compounds release to create layered tastes such as the earthy notes in chamomile or the citrusy brightness in lemon verbena infusions. Flavored waters, often made via cold infusion to preserve delicate flavors, involve submerging fruits or herbs like cucumber and mint in room-temperature water for several hours, resulting in subtle, refreshing drinks ideal for hydration with added nuance. These techniques allow chefs to customize beverages for seasonal ingredients, maintaining clarity and vibrancy in the final product. Infusions extend to cocktails, where they introduce complexity through infused simple syrups or directly steeped spirits, balancing sweetness and botanicals in drinks like a gin-based herbal tonic. For instance, steeping fresh rosemary or lavender in a sugar-water syrup for 24 hours imparts herbal depth that complements citrus or bitters, a practice common in modern mixology to elevate classic recipes. In cooking, infused oils and vinegars provide versatile bases for dressings and marinades, as seen when basil or garlic is steeped in extra virgin olive oil to create emulsions that coat salads or tenderize meats with infused essences. Herb-infused stocks, prepared by simmering vegetables and aromatics in water or broth, form the foundation of sauces and soups, where prolonged gentle heating extracts umami and fragrance without clouding the liquid. Global cuisines showcase infusion's adaptability, such as in Moroccan mint tea (atay bi n'na'na), where fresh spearmint leaves are infused with green tea and sugar in a ritualistic pour to aerate and meld bright, cooling flavors. In Italian cuisine, basil-infused oil, made by blending blanched basil leaves with olive oil and straining, adds vibrant, peppery notes to pasta dishes like aglio e olio or Caprese salads, preserving the herb's essential oils for immediate use. These examples highlight infusion's role in cultural traditions, where timing and temperature control ensure harmonious flavor integration. For commercial production, scaling infusion techniques requires adjustments in equipment to maintain consistency, particularly in heat transfer and mixing, as larger vessels reduce the surface area-to-volume ratio, potentially slowing extraction rates in processes like oil infusion. Manufacturers often employ jacketed tanks with controlled agitation to simulate small-batch results, ensuring uniform flavor distribution in products like bottled herb vinegars, while adhering to food safety standards for acidification in oil-based infusions to prevent microbial growth. Sensory outcomes from culinary infusions emphasize flavor balancing, where techniques like adding sweeteners mitigate bitterness in herbal brews, creating a rounded profile that enhances palatability across diverse palates. Berry infusions, such as those using blueberries or strawberries in vinegars, introduce tart acidity and natural color while contributing antioxidants that subtly enrich the taste without dominating, allowing for nuanced adjustments in sweetness and intensity.

Medicinal and Therapeutic Uses

Infusions, particularly herbal tisanes, have been employed in traditional and modern herbal medicine to address various health concerns, leveraging the extraction of bioactive compounds into water or other solvents. Peppermint (Mentha piperita) infusions are widely used for digestive issues, such as irritable bowel syndrome (IBS), due to the antispasmodic effects of menthol, which relaxes gastrointestinal smooth muscles and alleviates symptoms like abdominal pain and bloating.^[51] A 2019 systematic review of clinical trials confirmed peppermint oil's superiority over placebo in improving overall IBS symptoms; evidence for peppermint leaf infusions is limited.^[52] Chamomile (Matricaria recutita) infusions promote relaxation and sleep through apigenin, a flavonoid that binds to benzodiazepine receptors in the brain, exhibiting mild sedative properties.^[53] Systematic reviews indicate that daily chamomile consumption reduces anxiety and may improve sleep quality without significant adverse effects in most cases.^[54] For immune support, echinacea (Echinacea purpurea) infusions enhance white blood cell activity and cytokine modulation, potentially shortening the duration of upper respiratory infections.^[55] A 2007 meta-analysis of randomized controlled trials showed echinacea decreased the odds of developing the common cold by 58% (OR 0.42, 95% CI 0.25-0.71).^[56] The pharmacological efficacy of these infusions stems from the extraction of bioactive compounds, such as water-soluble polyphenols and flavonoids, which are released by hot water for gastrointestinal absorption. Ginger (Zingiber officinale) infusions exemplify this for nausea relief, with gingerols providing antiemetic effects. A 2014 meta-analysis of randomized trials demonstrated ginger's significant reduction in nausea severity during pregnancy (mean difference 1.20 on a standardized scale, p=0.0002), supporting its use over placebo at dosages around 1 g daily.^[57] Clinical trials support ginger's safety and efficacy for nausea. In contemporary therapeutic contexts, infusions extend to aromatherapy and topical applications, integrating into wellness practices for holistic benefits. Inhaled vapors from chamomile or lavender infusions can reduce stress and anxiety by influencing the limbic system, with emerging evidence from systematic reviews showing improved psychological outcomes in clinical settings.^[58] Topical infused compresses, such as those using ginger or turmeric, deliver anti-inflammatory compounds directly to affected areas, reducing pain in conditions like osteoarthritis. A systematic review and meta-analysis of Thai herbal compress trials found significant pain relief (standardized mean difference -0.85) and improved joint function, comparable to nonsteroidal anti-inflammatory drugs.^[59] Adaptogen-infused teas, featuring herbs like ashwagandha or rhodiola, align with wellness trends by modulating the hypothalamic-pituitary-adrenal axis to combat fatigue and stress; clinical studies report enhanced cognitive performance and reduced cortisol levels with daily consumption.^[60] Despite these benefits, cautions are essential due to potential interactions and variability in potency. St. John's wort (Hypericum perforatum) infusions, used for mood support, can induce cytochrome P450 enzymes, reducing the efficacy of medications like oral contraceptives, anticoagulants, and antidepressants, leading to risks such as unintended pregnancies or breakthrough bleeding.^[61] Clinical guidelines recommend dosages of 2-4 g dried herb daily for most infusions but advise against use in pregnancy, lactation, or with known allergies, emphasizing consultation with healthcare providers to avoid adulteration or overdose.^[62] Herbal infusions are classified as dietary supplements by regulatory bodies like the FDA, not drugs, and lack standardized potency; users should select products tested for contaminants. Overall, while infusions offer accessible therapeutic options, their safety profile underscores the need for standardized preparations and professional guidance.

Notable Examples

Common Herbal Infusions

Common herbal infusions encompass a range of plant-derived beverages that are widely consumed for their flavors and mild physiological effects. Among the most popular are true teas derived from the Camellia sinensis plant, which include black, green, and white varieties distinguished primarily by their processing methods. Black tea results from full oxidation of the leaves, leading to a robust flavor and higher levels of theaflavins, compounds formed during enzymatic browning that contribute to its characteristic color and potential antioxidant properties.^[63] Green tea undergoes minimal oxidation through steaming or pan-firing to preserve catechins, resulting in a fresh, vegetal taste and elevated levels of epigallocatechin gallate (EGCG), a potent polyphenol.^[64] White tea, made from young buds and leaves with the least processing—often just withering and drying—retains delicate flavors and higher concentrations of unaltered catechins compared to more processed teas.^[65] These processing differences influence infusion suitability, with black tea steeping well at higher temperatures for stronger brews, while green and white teas benefit from lower temperatures to avoid bitterness from excess tannin extraction.^[66] Beyond true teas, single-herb infusions from various plants offer distinct profiles. Peppermint (Mentha × piperita) infusion derives its cooling sensation from menthol, a monoterpene alcohol that provides antimicrobial and soothing effects on the digestive tract.^[52] Chamomile (Matricaria recutita) infusion contains apigenin and other flavonoids that bind to GABA receptors in the brain, promoting mild sedative and calming properties.^[67] Hibiscus (Hibiscus sabdariffa) calyces yield a tart infusion rich in antioxidants and organic acids like hibiscus acid that enhance its tangy flavor and antioxidant capacity.^[68] Commercial blends combine herbs to target specific effects, expanding the appeal of herbal infusions. Sleep aid blends often feature valerian root (Valeriana officinalis) paired with lavender (Lavandula angustifolia) for relaxation.^[69] Detox teas commonly mix dandelion root (Taraxacum officinale) and nettle leaf (Urtica dioica), though evidence for broad detoxification is limited.^[70] Sourcing and quality play crucial roles in the efficacy and safety of these infusions, with organic cultivation generally yielding lower pesticide residues compared to conventional methods.^[71] For true teas, caffeine content serves as a key quality marker, typically ranging from 14-61 mg per 8 oz serving across varieties, with organic teas often exhibiting reduced levels due to stress-minimizing farming practices that lower alkaloid production.^[72]^[73] Identification of such markers through chemical analysis ensures authenticity and helps consumers select high-quality products free from contaminants.^[74]

Specialized Infusions

Tinctures represent a specialized form of alcohol-based infusion where plant materials are macerated in high-proof ethanol to extract bioactive compounds, preserving their medicinal properties for extended shelf life and precise dosing.^[75] This method concentrates volatile oils, alkaloids, and other phytochemicals more effectively than water-based infusions, making tinctures a staple in herbal medicine for treating conditions like anxiety or inflammation through sublingual or topical application.^[76] In culinary contexts, vanilla extract exemplifies this technique, produced by infusing vanilla beans in a 35% alcohol solution for weeks to months, yielding a flavorful essence used in baking and desserts.^[77] Beyond plant-derived applications, infusions extend to non-botanical materials in perfumery, where coffee beans or spices like cardamom are gently steeped in carrier oils or alcohol to capture aromatic essences for fragrance compounding.^[78] For instance, coffee infusions contribute roasted, nutty top notes in niche perfumes, often blended with spice extracts to evoke exotic profiles.^[79] In industrial food processing, steam infusion employs direct-contact culinary steam under partial vacuum to rapidly heat and mix liquids like sauces or dairy products, achieving uniform cooking in seconds while minimizing nutrient degradation and burn-on risks.^[80] This technology enhances efficiency in producing items such as puddings and baby foods by condensing steam directly onto the product surface.^[81] Cultural traditions showcase unique infusion variants, such as matcha, a powdered green tea prepared by sifting finely ground leaves and whisking them vigorously into hot water (around 70–80°C) to form a frothy suspension rather than a traditional steep.^[82] This method, rooted in Japanese tea ceremonies, ensures full dispersion of the powder for a concentrated, umami-rich beverage.^[83] Similarly, yerba mate involves steeping dried leaves in a shared gourd (mate) with hot water, passed socially in South American cultures like Argentina and Uruguay, where the infusion's bitterness fosters communal rituals without full extraction to maintain repeated servings.^[84] Absinthe, a hallmark of European apothecary traditions, begins with an alcohol rinse or maceration of wormwood (Artemisia absinthium) alongside anise and fennel, followed by distillation to create a high-proof spirit that louches opaquely when diluted with water.^[85] Innovations in infusion technology include ultrasound-assisted methods, which use high-frequency sound waves to cavitate solvents and accelerate mass transfer, boosting extraction yields by up to 50% in food and medicinal applications while reducing processing time and temperature.^[86] This non-thermal approach enhances efficiency in extracting polyphenols from teas or impregnating fruits with vitamins, preserving sensory qualities.^[87] Post-2018, the U.S. Farm Bill's legalization of hemp-derived CBD (with <0.3% THC) spurred commercialization of CBD-infused oils, transforming carrier oils like MCT through simple infusion or emulsification for wellness products targeting anxiety relief and inflammation.^[88] By 2025, this sector has grown to approximately USD 10.68 billion, though FDA oversight limits unapproved health claims.^[89]

References

[1]
Definition of infusion - NCI Dictionary of Cancer Terms
A method of putting fluids, including drugs, into the bloodstream. Also called intravenous infusion.
[2]
Infusion Therapy: What Is It, What Conditions Does It Treat?
Dec 21, 2020 · Infusion therapy is when medication or fluids are administered through a needle or catheter. It's a way of delivering medication that can't be taken orally.Definition · Conditions used for · What to expect
[3]
Medical Infusion Therapy: Uses, Benefits, and Side Effects
Medical infusion therapy involves administering drugs directly into the bloodstream to treat many health conditions. Learn more about it.
[4]
The history of intravenous therapy - PubMed
Modern IV therapy is less than a century old. Yet, it was known that medications could be injected into a vein as early as the 1600s. Because of a lack of ...
[5]
The History of Intravenous Therapy - Journal of Infusion Nursing
Modern IV therapy is less than a century old. Yet, it was known that medications could be injected into a vein as early as the 1600s. Because of a lack of ...
[6]
Home Infusion Therapy/Home IVIG Services - CMS
Mar 21, 2025 · Home infusion therapy involves the intravenous or subcutaneous administration of drugs or biologicals to an individual at home.Home Infusion Therapy Archive · View data · Hospice · Billing and Rates
[7]
Preparation of Medicinal Plants: Basic Extraction and Fractionation ...
Jan 29, 2020 · It involves extraction and determination of quality and quantity of bioactive constituents before proceeding with the intended biological ...Solvents Of Extraction · Phytochemical Screening... · Fractionation And...
[8]
Techniques for extraction and isolation of natural products
Apr 17, 2018 · Extraction methods include solvent extraction, distillation method, pressing and sublimation according to the extraction principle. Solvent ...
[9]
None
### Summary of Infusion and Related Extraction Techniques
[10]
Extraction of phenolic compounds: A review - ScienceDirect.com
This review mainly focuses on the phenolic compounds and several methods of extraction that are used to obtaining them from plant materials.
[11]
Modelling the kinetics of tea and coffee infusion - Wiley Online Library
Oct 1, 2002 · However, Spiro17 has ventured an analysis for tea infusion that is able to explain the intercept as a direct prediction of Fick's second law.
[12]
Swelling kinetics of tea in hot water - PMC - NIH
Theoretical modeling was done based on the assumption that the hydration takes place due to Fick's law of diffusion. ... tea infusion samples was converted to ...
[13]
Extraction, Characterization, Stability and Biological Activity of ... - NIH
The flavonoids are stable between the pH 5 and 7. The flavonoids tends to degrade with 6% observed at pH 8; 9% at pH 9; and 11–12% between pH 10–12; ...
[14]
Available technologies on improving the stability of polyphenols in ...
Mar 24, 2021 · It was reported that the stability of phenolic compounds such as alkaloids, terpenoids, and terpenes is mainly affected by water activity ( ...
[15]
Effect of pH on cream particle formation and solids extraction yield of ...
Solids extraction yield was doubled when tea was extracted at pH 1.2 compared with that extracted in boiling distilled water with pH 6.8.Missing: herbal | Show results with:herbal
[16]
Effect of extraction methods on yield, phytochemical constituents ...
Extraction yield (mass of extract/mass of dry matter) was used as an indicator of the effects of the extraction conditions. In reflux, water extract yield (9.51 ...
[17]
Prehistoric medicine: Research, disease prevention, and medications
Nov 2, 2018 · There is some evidence from present-day archeological sites in Iraq that people used mallow and yarrow about 60,000 years ago. Yarrow (Achillea ...
[18]
Fermented beverages of pre- and proto-historic China - PMC
Dec 21, 2004 · Chemical analyses of ancient organics absorbed into pottery jars from the early Neolithic village of Jiahu in Henan province in China have ...
[19]
Traditional ancient Egyptian medicine: A review - PMC - NIH
Jun 19, 2021 · The first known medical reference to diabetes mellitus was the Ebers Papyrus containing the following description; “. ... Chamomile (Matricaria ...
[20]
[PDF] Ancient Herbs in the J. Paul Getty Museum Gardens
Most of Hippocrates' materia medica came from the plant world, and he left a list of several hundred herbal simples (herbs used singly as cures). Some of the ...
[21]
https://www.portaltea.co/post/the-legend-of-tea-s-discovery-emperor-shennong-s-accidental-brew
[22]
Indian Traditional Ayurvedic System of Medicine and Nutritional ...
This review gives an overview of the Ayurvedic system of medicine and its role in translational medicine in order to overcome malnutrition and related ...
[23]
Sweat Lodge - The Pluralism Project
Sweat ceremonies involve heating stones until they are red hot, bringing them into the darkened chamber, and pouring water or aromatic herbal teas over them to ...Missing: infusion | Show results with:infusion
[24]
Ancient African Medicine
Aug 3, 2025 · Rituals might include drumming, chanting, or dancing to restore harmony between the patient and the spiritual world. Protective charms, amulets, ...
[25]
Culpeper's complete herbal : consisting of a comprehensive ...
Jan 26, 2009 · A comprehensive description of nearly all herbs with their medicinal properties and directions for compounding the medicines extracted from them.Missing: Renaissance apothecaries
[26]
Pharmacy, Testing, and the Language of Truth in Renaissance Italy
In Renaissance Italy, apothecaries focused on authenticating ingredients using a "language of truth" and "tweaking" recipes, not on efficacy testing.
[27]
The historical development of pharmacopoeias and the inclusion of ...
Aug 10, 2019 · The research focus in Europe and the US resulted in a persistence of herbal drugs with a historic importance in the European and US pharmacopoeias.
[28]
A Brief History of the Tea Bag - Time Magazine
Sep 3, 2015 · The original single-serving, low-cleanup caffeine delivery method actually hit the market more than 100 years ago ago.Missing: accurate | Show results with:accurate
[29]
Teekanne History
1929. Invention of the Tea Bag Packing Machine. The Pompadour machine developed by Rudolf Rambold is ready for production and is marketed worldwide with great ...
[30]
A brief history of tea makers - Tea 101
May 4, 2017 · With the Industrial Revolution in full force, production was easy and infusers of various shapes and sizes flooded the market.
[31]
Plants used for making recreational tea in Europe - PubMed Central
Aug 13, 2013 · As can be seen in Additional file 1, in the 29 different regions of Europe studied, 142 taxa were used for making recreational herbal teas.Missing: commercialization | Show results with:commercialization<|separator|>
[32]
Consumer Trends in the Herbal Tea Market: A Systematic Literature ...
Apr 16, 2025 · The review examines the global herbal tea market, analyzing global economic dynamics and regional consumption trends. It highlights rising ...
[33]
Matcha is now a global wellness trend but what makes this ...
Aug 25, 2025 · Matcha, traditionally used in Japanese tea ceremonies, has exploded into a global wellness trend. Its popularity stems from its unique ...Missing: herbal infusion
[34]
A Short History of Infusion
Jun 9, 2018 · Long before infusions were called infusions, they were typically called tonics, cordials, liqueurs or medicinals. The concept was the same, ...
[35]
Dietary Supplements - FDA
Oct 1, 2024 · FDA regulates dietary supplements under a different set of regulations than those covering conventional foods and drug products.Information on Select Dietary... · New Dietary Ingredient (NDI)Missing: infusions | Show results with:infusions
[36]
How to Brew a Perfect Cup of Tea - Dilmah School of Tea
DOSAGE ; WHITE TEA, 70-80°C ; GREEN TEA, 70-80°C ; OOLONG TEA, 80-90°C ; BLACK TEA, 95-100°C ; INFUSIONS, 95-100°C ...
[37]
The Engineer's Guide to Tea Preparation - Tea Epicure
Feb 22, 2019 · Tea (the beverage) is made by infusing tea leaves in a solvent (water) to make a solution wherein the solute is made up of the soluble solids within the tea ...
[38]
https://specialtyteaalliance.org/world-of-tea/tea-chemistry/
[39]
Chemical Compounds in Tea - Tea Epicure
Dec 14, 2023 · In steeped teas, polyphenols are largely responsible for astringency, a taste experience that causes a drying sensation on the tongue and ...
[40]
Herbal Infusions and Decoctions - Preparing Medicinal Teas
Decoctions are typically made in a stainless steel or stovetop-safe glass pot. The herb is placed in water and brought to a boil, then simmered with a lid on ...
[41]
Effects of different brewing conditions on catechin content and ... - NIH
Green tea is typically prepared as an infusion by immersing dried green teas in hot water at around 80-90 °C for a period of 3–4 min. Many parameters may affect ...
[42]
Effects of alternative steeping methods on composition, antioxidant ...
Jul 29, 2015 · Recently, cold water (4 °C or room temperature) steeping become a new popular way for infusion. It provides lower caffeine, lower bitter taste ...
[43]
Impact of Cold versus Hot Brewing on the Phenolic Profile and ... - NIH
Oct 21, 2019 · The results reported here indeed show that cold-brewed rooibos differs in antioxidant capacity and phenolic profile compared to the hot brews, ...
[44]
(PDF) Hot vs. cold water steeping of different teas: Do they affect ...
Cold steeping significantly enhances antioxidant activity in white tea compared to hot steeping. The study evaluates how steeping temperature impacts ...
[45]
How to Safely Make Infused Oils - Penn State Extension
Apr 4, 2024 · A method of preparing a select list of fresh herbs or garlic has been tested that will allow the home food preserver to safely prepare infused oils for long ...Missing: sun | Show results with:sun
[46]
Oxidative Stability, Microbial Safety, and Sensory Properties of ... - NIH
May 15, 2021 · An increase in antioxidant values in all infused oils occurred during the second and fourth months of storage due to extraction of phenolic ...
[47]
Understanding plant to extract ratios in botanical extracts - PMC - NIH
Sep 30, 2022 · In the case of liquid extracts, a 1:1 ratio defines fluidextracts. Author contributions. JB, SD, SG, RM, MM, and HO-R: Prepared the manuscript ...Missing: alcohol | Show results with:alcohol
[48]
Tincture - an overview | ScienceDirect Topics
For extraction of water and lipid-soluble herb components, alcohol and water proportions may range from 20 : 80 to 40 : 60 (vodka is conveniently made this way) ...<|separator|>
[49]
https://hgic.clemson.edu/factsheet/flavored-vinegars/
[50]
Glycerites: How to Use Vegetable Glycerine to Extract Herbal ...
Jun 20, 2024 · If stored properly in a cool, dark place, glycerites made with no alcohol have a shelf life of approximately 1-2 years (compared to 4-6 ...
[51]
Flavored Vinegars - HGIC@clemson.edu
Feb 13, 2019 · Always keep vinegar containers tightly sealed. If properly prepared and bottled, flavored vinegars should keep for up to three months in cool ...Equipment · Ingredients · Flavoring The VinegarMissing: culinary | Show results with:culinary
[52]
How to Make Herbal Vinegar - Mountain Rose Herbs Blog
Oct 1, 2018 · Because of the acidic nature of vinegar, it's best to use glass for your extractions. Avoid plastic, as it can leach into your vinegar. You can ...
[53]
Review article: The physiologic effects and safety of Peppermint Oil ...
Mar 1, 2019 · Peppermint oil has been found to affect esophageal, gastric, small bowel, gallbladder, and colonic physiology.
[54]
Peppermint Oil: Usefulness and Safety | NCCIH
A 2022 review of 10 studies (involving 1,030 participants) found that peppermint oil was better than placebo at improving overall IBS symptoms and reducing ...
[55]
A Comprehensive Study of Therapeutic Applications of Chamomile
Oct 19, 2022 · Some authors reported that the sedative effect is due to a flavonoid, apigenin, found in chamomile [47].
[56]
The Effect of Oral Chamomile on Anxiety: A Systematic Review of ...
Most studies showed that daily consumption of chamomile is effective in improving anxiety and no threatening or adverse side effects were reported. In patients ...
[57]
Evaluation of echinacea for the prevention and treatment of the ...
An analysis of the current evidence in the literature suggests that echinacea has a benefit in decreasing the incidence and duration of the common cold.Missing: infusion | Show results with:infusion
[58]
Efficacy and safety of Echinacea purpurea in treating upper ...
Conclusion. The meta-analysis of nine studies found that E. purpurea was effective in reducing the duration of treatment, the incidence of episodes, and ...Missing: infusion | Show results with:infusion
[59]
Are Herbal Capsules as Effective as Teas? Here's What to Know
Absorption and Bioavailability One key difference between herbal capsules vs tea lies in how your body absorbs the herbs. With tea, the hot water helps extract ...
[60]
A systematic review and meta-analysis of the effect and safety of ...
Mar 19, 2014 · Ginger significantly improved the symptoms of nausea when compared to placebo (MD 1.20, 95% CI 0.56-1.84, p = 0.0002, I2 = 0%). Ginger did not ...
[61]
Clinical Aromatherapy - PMC - PubMed Central - NIH
Sep 28, 2020 · Clinical aromatherapy is an alternative medicine therapy that can be beneficial in the inpatient or outpatient setting for symptom management.
[62]
Clinical Effects of Thai Herbal Compress: A Systematic Review and ...
Mar 12, 2015 · Thai herbal compress may be considered as an alternative for osteoarthritis and muscle pain and could also be used as a treatment of choice to induce lactation.
[63]
Effects of Adaptogens on the Central Nervous System and the ...
The evidence points to adaptogens may be beneficial on neurodegenerative disorders [54,83,84,89,135,141]. 4.1. Adaptogens in Fatigue, Effect on Cognitive ...4. Clinical Studies · 4.2. Adaptogens In Asthenia... · 4.2. 1. Rhodiola RoseaMissing: trends | Show results with:trends
[64]
St. John's wort - Mayo Clinic
Mar 21, 2025 · St. John's wort interacts with many medicines. So it might not be a suitable choice, especially if you take any prescription medicines. ...
[65]
WHO monographs on selected medicinal plants
Dec 12, 2006 · WHO monographs on selected medicinal plants. Download (2.6 MB). WHO Team. WHO Headquarters (HQ). Number of pages. 297. Reference numbers.
[66]
Brewing Up the Latest Tea Research - USDA AgResearch Magazine
When fermentation is completely arrested, the tea stays "green" or yellowish brown. When fermentation time is long, the leaves darken and become "black" tea.
[67]
Tea | Linus Pauling Institute | Oregon State University
When tea leaves are intentionally broken or rolled during processing, cell compartmentalization is disrupted and PPO comes into contact with catechins. This ...
[68]
Characterization of white tea metabolome - PubMed
White tea is considered the least processed form of tea and is reported to have a series of potent bioactivities, such as antioxidant, anti-inflammatory, anti- ...
[69]
[PDF] Srijana Shrestha and Carol Miles WSU Mount Vernon NWREC ...
All tea made from Camellia sinensis starts by harvesting fresh, young leaves. Green tea: a non-fermented type of tea made by withering*, steaming, rolling/ ...
[70]
Chamomile: A herbal medicine of the past with bright future - PMC
Traditionally, chamomile preparations such as tea and essential oil aromatherapy have been used to treat insomnia and to induce sedation (calming effects).
[71]
The health benefits of 3 herbal teas - Harvard Health
Chamomile tea is more than just a calming beverage to consume before bedtime. ... Chamomile contains a variety of bioactive phytochemicals, notably flavonoids ...
[72]
Herbal teas for relaxation | ILRiverHort - Illinois Extension
Sep 10, 2018 · Those sometimes touted as good evening teas for relaxation include lavender, chamomile, and valerian.
[73]
Drug-Induced Liver Injury from Herbal Liver Detoxification Tea - NIH
Nov 8, 2022 · Of note, she reported using herbal tea for liver detoxification for 1 month, with active ingredients including burdock root, stinging nettle ...
[74]
Organic Food in Athletes Diet—Narrative Review of Alternative ... - NIH
Certified organic food is characterized by an almost complete absence of synthetic pesticide residues and antibiotics, and a complete absence of synthetic food ...
[75]
Quality analysis and characteristic difference identification of organic ...
Feb 22, 2025 · Organic tea has been found to contain lower caffeine levels than conventional planting tea, suggesting a potentially milder bitter taste. The ...
[76]
Tea - The Nutrition Source
Though green tea is often believed to be richer in polyphenols than black or oolong (red) teas, studies show that—with the exception of decaffeinated tea—all ...<|control11|><|separator|>
[77]
Chemical Analysis of Various Tea Samples Concerning Volatile ...
Aug 15, 2023 · Tea quality is strongly correlated with catechins, caffeine, volatile compounds, and amino acids in harvestable tea shoots [12]. The ...<|control11|><|separator|>
[78]
3 Tinctures for Your Wellness Business
Tinctures can also be used topically for calming wounds, in the bath, or as a household disinfectant. Learn more about How to Make A Successful Herbal Tincture ...
[79]
[PDF] The Herbal Apothecary
Lavender: Renowned for relaxation and sleep support, lavender is often used in teas, essential oils, and balms. Turmeric: Known for its powerful anti ...
[80]
[PDF] SELLING HERBAL OR DIETARY SUPPLEMENTS - | WA.gov
Tinctures and herbal extracts may have 20-90 percent alcohol content; however, as used, the alcohol content should be 0.5 percent or less.
[81]
https://pmc.ncbi.nlm.nih.gov/articles/PMC8393886/
[82]
The Art Of Crafting Resinous Scents - A Perfumer's Guide
Sep 5, 2023 · This artful practice revolves around the creation of resinous scents, a category of fragrances that taps into the rich aromatic potential of natural resins.
[83]
Steam Basics for Food Processors | Oklahoma State University
Steam infusion is another method of steam heating where the food product is heated by relatively low-pressure, culinary steam. A steam infusion device usually ...
[84]
Transformational Steam Infusion Processing for Resilient and ... - NIH
Jul 30, 2021 · The Steam Infusion process is a direct contact heating process whereby steam is directly injected into the liquid food via the Vaction™ pump, ...
[85]
https://www.wormwoodsociety.org/proper-absinthe-preparations/
[86]
Complete Ceremonial Matcha Preparation - Nio Teas
Rating 5.0 (6) · 7 minJul 7, 2022 · Using the bamboo whisk, first stir gently to combine powder and water. Then whisk briskly in a zigzag (M or W) motion with your wrist until a ...
[87]
Yerba Mate 101
Today, yerba mate is consumed around the world, and a gourd circle (ronda/roda de mate), the cultural practice of sharing yerba mate among friends, has the ...
[88]
The Proper Way To Prepare Absinthe In Society
Here is everything you need to enjoy absinthe in the traditional manner: fine absinthe, a glass, an absinthe spoon, sugar, and a carafe full of ice-cold water.
[89]
Direct Contact Ultrasound in Food Processing: Impact on Food Quality
Ultrasound (US) is a non-thermal technology that enhances mass and energy transfer processes resulting in improved food quality.
[90]
Applications of ultrasound in food technology - ScienceDirect.com
The advantages of using ultrasound for food processing, includes: more effective mixing and micro-mixing, faster energy and mass transfer, reduced thermal and ...
[91]
FDA Regulation of Cannabis and Cannabis-Derived Products
Jul 16, 2024 · Even if a CBD product meets the definition of "hemp" under the 2018 Farm Bill (see Question #2), it still must comply with all other applicable ...
[92]
What Does the 2018 Farm Bill Mean for the Hemp and CBD ...
Dec 31, 2018 · Among the 2018 Farm Bill's broad-ranging provisions, it legalizes the cultivation and sale of hemp at the federal level, effective January 1, 2019.