Alfred Bader
Alfred Bader (28 April 1924 – 23 December 2018) was an Austrian-born American chemist, entrepreneur, philanthropist, and art collector renowned for co-founding the Aldrich Chemical Company in 1951, which pioneered the rapid supply of small quantities of research chemicals to scientists worldwide.[1][2]
A Jewish refugee who escaped Nazi persecution via the Kindertransport to England at age 14, Bader studied at Queen's University in Canada, earning degrees in chemistry and history, before completing a PhD at Harvard University.[1] He relocated to Milwaukee, Wisconsin, where Aldrich grew substantially, merging with Sigma Chemical in 1975 to form Sigma-Aldrich, a global leader in laboratory supplies that transformed scientific research efficiency.[2][3]
In parallel with his chemical innovations, Bader developed a passion for 17th-century Northern European art, amassing the Bader Collection of over 500 Dutch and Flemish Old Master paintings, sculptures, and drawings, which he generously donated to institutions like the Agnes Etherington Art Centre at Queen's University.[4][1] His dual pursuits are chronicled in his autobiographies, Adventures of a Chemist Collector and Chemistry & Art: Further Adventures of a Chemist Collector, underscoring his commitment to advancing both science and cultural heritage through philanthropy via the Bader Foundation.[1]
Early Life
Childhood in Vienna
Alfred Bader was born on April 28, 1924, in Vienna, Austria, to a Jewish father of Czech ancestry and a mother, Elizabeth Serenyi, from a Catholic Hungarian aristocratic family whose parents had disowned her upon her marriage.[5][6] His father died two weeks after his birth, leaving the infant Bader to be adopted and raised by his paternal aunt, Gisela Reich, a childless widow who had been close to her brother and treated Bader as her own son.[5][1] Gisela, whom Bader regarded as his true mother, brought him up in the Jewish faith in a household dominated by women, including herself and two other female relatives, amid the economic hardships following Austria's post-World War I inflation that eroded family wealth. Bader had one half-sister from his biological mother's side, who was raised Catholic and survived the war.[5] Bader's early years were marked by a stable yet modest domestic life in Vienna, where his adoptive mother provided a nurturing environment despite occasional visits from his biological mother, with whom he shared little emotional bond.[5] Daily routines included school in the mornings, followed by afternoons spent playing soccer with neighborhood friends, reflecting a typical urban childhood for a boy of his background before the escalating political tensions of the 1930s.[5] Financial constraints were evident, but Bader developed an early entrepreneurial streak through hobbies that generated small income. From age 10 to 14, Bader attended a Realgymnasium, a secondary school emphasizing sciences and Latin, where he studied under notable instructors such as German teacher Professor Sedlmayer.[5] His interests leaned toward collecting, beginning with postage stamps at age six—a pursuit that by age 14 involved buying and selling them actively, especially in the latter half of 1938, to supplement family resources.[5] This period also saw nascent artistic inclinations, as Bader recalled acquiring his first drawing around age 10, foreshadowing his later renown as an art collector.[5] School days typically ran from 8 a.m. to 1 p.m., leaving time for such personal endeavors in a city still vibrant culturally despite underlying antisemitic currents.[5]Nazi Persecution, Escape, and Internment
Born in Vienna on April 28, 1924, to Jewish parents, Alfred Bader grew up in a city where, following the Anschluss on March 12, 1938, Jews endured systematic persecution, including property confiscation under Aryanization laws, exclusion from schools and professions, public humiliations, and pogroms such as Kristallnacht on November 9-10, 1938. As a 13-year-old boy of Jewish descent, Bader faced immediate restrictions on education and daily life, prompting urgent efforts by his family to secure his emigration amid escalating violence and deportations.[5] To evade further persecution, Bader was selected for the Kindertransport program, a rescue operation organized by British Quakers, Jewish agencies, and the British government that evacuated approximately 10,000 Jewish children from Nazi-controlled territories to the United Kingdom between December 1938 and September 1939. On December 10, 1938, at age 14, he departed Vienna by train, crossing into the Netherlands before ferrying to England, where he was hosted by foster families and attended the Quaker-run Oundle School in Northamptonshire.[7][8][9] Despite his refugee status and opposition to Nazism, Bader was classified as an "enemy alien" under British wartime policy after the outbreak of World War II in September 1939, which led to the internment of over 70,000 individuals from Axis countries, including many Jewish refugees reclassified amid fears of fifth columnists following the fall of France in June 1940. In July 1940, he was arrested, briefly held at Huyton camp near Liverpool, and then deported to Canada aboard the SS Ettrick with about 2,000 other internees—predominantly Jewish refugees—to alleviate British prison overcrowding.[10][8][7] Upon arrival in Quebec on July 13, 1940, Bader was transported by rail to Internment Camp Sherbrooke in Quebec's Eastern Townships, where conditions resembled prisoner-of-war facilities: barbed wire, wooden barracks, and military oversight, though internees organized self-governance, education classes, and even a camp orchestra among the roughly 800 civilian detainees, mostly German and Austrian Jews.[8][11] He remained there for approximately one year, engaging in studies and manual labor, until his release in mid-1941 after Quaker advocacy and security vetting confirmed his low risk, allowing him to pursue education in Canada.[10][7]Education
Studies at Queen's University
Following his release from internment in 1941, Bader enrolled mid-term at Queen's University in Kingston, Ontario, where he was accepted despite his status as a former enemy alien.[12][13] The university provided him with opportunities that contrasted sharply with prior rejections from other Canadian institutions, treating him equitably during his studies amid World War II.[14] Bader initially focused on engineering chemistry, earning a Bachelor of Science degree in the field in 1945 after completing the required coursework and examinations.[6][5] Reflecting his broad intellectual interests, he simultaneously pursued humanities studies, obtaining a Bachelor of Arts in history in 1946.[6][5] He remained at Queen's for graduate work, completing a Master of Science in chemistry in 1947, which involved advanced research and built directly on his undergraduate training.[15][16] These degrees, achieved in rapid succession despite wartime disruptions, demonstrated his aptitude for integrating scientific rigor with historical analysis, a pattern that influenced his later career.[6]Graduate Research and Early Publications
Bader completed his Master of Science in chemistry at Queen's University in 1947 under the supervision of Arthur F. McKay.[5] His thesis research focused on the oxidation of linoleic acid, which yielded eight isomeric tetrahydroxystearic acids, involving experimental organic chemistry techniques to purify challenging waxy compounds.[5] This work resulted in an early publication on the oxidation process, though subsequent analysis by Daniel Swern corrected aspects of its stereochemistry.[5] In 1947, Bader proceeded to Harvard University, where he earned a PhD in organic chemistry in 1950, advised by Louis F. Fieser.[17] [5] His doctoral thesis examined the mechanism of the Hooker oxidation, emphasizing rearrangements of hydroxyquinones and the synthesis of naphthoquinones.[5] Key outputs included a collaborative paper with Fieser detailing the Hooker oxidation mechanism and a co-authored publication with Martin Ettlinger on naphthoquinone structures.[5] These efforts marked Bader's initial contributions to synthetic organic mechanisms, laying groundwork for his later industrial applications in chemical synthesis.[5]Professional Career
Initial Employment in Chemistry
After earning his PhD in organic chemistry from Harvard University in 1950, Alfred Bader relocated to Milwaukee, Wisconsin, to accept a position as a research chemist with Pittsburgh Plate Glass Company (PPG).[7] His employment began in the winter of 1950, at a starting salary of $400 per month.[18] The move to PPG, a major manufacturer of glass, paints, and coatings, capitalized on Bader's prior familiarity with the acquired Murphy Paint Company, where he had gained early industrial experience before graduate studies.[5] In his role at PPG's research division, Bader focused on organic synthesis projects aligned with the company's needs in pigment and coating development, applying his expertise in fine chemicals to industrial applications.[2] This period marked his transition from academia to industry, where he identified gaps in the availability of specialized research chemicals—a realization that would soon influence his entrepreneurial path.[19] Bader remained with PPG through 1951, advancing to oversee aspects of organic group leadership amid his growing involvement in a nascent chemical supply venture.[5]Founding and Expansion of Aldrich Chemical
In 1951, Alfred Bader co-founded Aldrich Chemical Company with his friend and attorney Jack Eisendrath in Milwaukee, Wisconsin, each contributing $250 in initial capital.[20] The venture began operations in a rented garage, focusing on the manufacture and distribution of organic research chemicals that were scarce or difficult to obtain from traditional suppliers.[19] The company's inaugural product was 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), promoted via a single-page catalog, marking the start of a catalog-driven model that emphasized accessibility for academic and industrial researchers.[21] Bader, leveraging his expertise as a research chemist previously employed at PPG Industries, assumed the role of chief chemist from 1954 to 1955 before becoming president in 1955, a position he held until 1975.[5] Early growth involved Bader's personal travels to Europe and the United Kingdom between 1951 and 1954 to establish supply collaborations, enabling the sourcing of specialized reagents not readily available domestically.[22] By 1958, the company had relocated from the garage to facilities in Milwaukee's central city, reflecting initial expansion amid rising demand for research-grade organics.[1] The firm's expansion accelerated through iterative catalog development, evolving from basic listings to the comprehensive Aldrich Handbook by 1967–1968, which incorporated distinctive artwork such as Paulus Lesire's The Quill Cutter and eventually cataloged approximately 68,000 compounds.[21] Aldrich went public via an initial public offering in 1966, providing capital for further scaling of production and distribution.[23] Bader also launched Aldrichimica Acta, a free journal disseminating practical organic synthesis techniques, which bolstered the company's reputation and customer loyalty among chemists.[21] This period saw Aldrich grow into a key supplier, creating hundreds of family-sustaining jobs and establishing a niche in rapid, reliable delivery of high-purity chemicals essential for laboratory innovation.[1]Merger with Sigma and Industry Leadership
In 1975, Alfred Bader's Aldrich Chemical Company merged with Sigma Chemical Corporation to form Sigma-Aldrich Corporation, combining Aldrich's focus on organic fine chemicals with Sigma's strengths in biochemicals and enzymes.[24][25] The merger, valued at approximately $20 million in stock and assets, enabled broader product catalogs exceeding 10,000 compounds by the late 1970s and expanded international distribution networks, positioning the entity as a dominant supplier to academic and industrial laboratories worldwide.[24][26] Bader assumed the role of president of Sigma-Aldrich from 1975 to 1980, overseeing operational integration and aggressive growth strategies that increased annual revenues from $25 million in 1975 to over $100 million by 1980.[26][25] He then served as chairman from 1980 to 1988, during which the company pioneered innovations like detailed spectral data in catalogs and rapid custom synthesis services, displacing Eastman Kodak as the primary source for research-grade organic chemicals in North America and Europe.[27][26] Under Bader's leadership, Sigma-Aldrich achieved industry dominance by emphasizing researcher-centric supply chains, including just-in-time inventory and global subsidiaries in over 30 countries by the mid-1980s, culminating in a market capitalization exceeding $1 billion by the time of his chairmanship's end.[24][25] This era solidified the company's reputation for reliability and innovation, with Bader's hands-on involvement in product selection and the editorial direction of Aldrichimica Acta—a quarterly journal launched in 1968 and continued post-merger—further enhancing its thought leadership in organic synthesis.[27][21]Scientific Contributions
Innovations in Organic Synthesis
Bader's doctoral research at Harvard University under Louis F. Fieser from 1947 to 1949 focused on synthetic organic chemistry, contributing to methodologies in complex molecule assembly during an era of advancing steroid and quinone syntheses in Fieser's laboratory.[28][5] Fieser's group emphasized practical, scalable routes to biologically active compounds, and Bader's work aligned with efforts to refine reaction conditions for naphthoquinone derivatives and related heterocycles, though specific publications from this period highlight incremental improvements in yield and selectivity rather than wholly novel transformations.[29] Following his Ph.D., Bader served as Research Chemist and Organic Group Leader at Pittsburgh Plate Glass (PPG) Industries from 1950 to 1954, where he developed noncatalytic transesterification processes, enabling ester exchanges under milder conditions without traditional acid or base catalysts, which improved efficiency in industrial-scale organic preparations.[7] This method relied on equilibrium-driven rearrangements facilitated by solvent selection and temperature control, offering advantages in avoiding side reactions common in catalyzed variants. Concurrently, Bader synthesized analogs of vitamin A (retinol), exploring structural modifications to enhance stability or bioactivity for potential nutritional or therapeutic applications, building on emerging understandings of carotenoid chemistry.[7] These efforts demonstrated practical innovations in handling labile polyene systems, though they remained proprietary industrial developments rather than broadly disseminated academic protocols. Bader's later involvement in chemistry, post-1954, shifted toward oversight of reagent development at Aldrich Chemical, but his direct synthetic innovations diminished as business leadership took precedence; nevertheless, his early transesterification insights influenced subsequent catalog offerings of related reagents for academic use.[30] No major paradigm-shifting reactions are attributed to him in peer-reviewed literature beyond these phases, reflecting a career pivot from bench research to enabling broader synthetic access through commercial means.[21]Revolutionizing Research Chemical Supply
In 1951, Alfred Bader co-founded the Aldrich Chemical Company with attorney Jack Eisendrath, investing $250 each to establish operations in a Milwaukee garage, with the explicit aim of supplying small quantities of rare and obscure organic research chemicals to academic and industrial researchers who lacked access through traditional bulk-focused suppliers like Eastman Kodak.[26][30] This approach addressed a critical market gap, as major chemical firms prioritized large-scale production for manufacturing, often ignoring the needs of laboratories requiring gram-scale amounts of specialized compounds for experimentation.[27] By sourcing intermediates from European and domestic producers—initially through personal travels and collaborations—Bader repackaged and distributed these materials, emphasizing high purity and rapid fulfillment to enable agile research workflows.[22] A key innovation was the development of Aldrich's catalogs, beginning in the 1950s, which featured detailed chemical structures alongside names and properties, allowing chemists to visually identify and select compounds without relying solely on nomenclature—a departure from prevailing industry practices that hindered accessibility for non-specialists.[21] These catalogs, later enhanced with artistic covers, evolved into comprehensive handbooks that cataloged thousands of items, including the 1966-launched Rare Chemical Library (initially Alfred Bader Chemicals), which specialized in hard-to-find reagents and further expanded the repertoire of available synthesis building blocks.[31] This catalog-driven model not only democratized access to diverse reagents but also fostered innovation in organic synthesis by reducing procurement barriers, as evidenced by Aldrich's displacement of Eastman Kodak as the dominant supplier to academic institutions by the 1960s.[27] The company's growth reflected the efficacy of this supply revolution: from a startup handling modest orders, Aldrich scaled to become the world's largest provider of research chemicals, with annual sales exceeding expectations through a focus on customer-centric service, including custom synthesis and just-in-time delivery that minimized researcher downtime.[17] Bader's hands-on synthesis of novel compounds to fill catalog gaps—drawing on his expertise in organic chemistry—ensured product reliability, while the firm's versatility in offering both common and esoteric materials accelerated discoveries across fields like pharmaceuticals and materials science.[19] This model, sustained post-merger with Sigma in 1975 to form Sigma-Aldrich, set enduring standards for the research chemical industry, prioritizing empirical demand from end-users over industrial-scale economics.[32]Art Collecting and Cultural Patronage
Building the Collection
Alfred Bader's interest in art originated in his childhood in Vienna, where, at age 10, he purchased his first drawing at the Dorotheum auction house for 10 Austrian shillings, forgoing the purchase of a camera.[33] This early acquisition foreshadowed a lifelong passion, influenced by his parents' collection of modern works by artists such as Gustav Klimt and Egon Schiele, though Bader gravitated toward 17th-century Dutch and Flemish old masters.[33] Bader acquired his first old master painting during a business trip to New York in the early 1950s, purchasing a Flemish work circa 1630—a portrait of Adriaen Brouwer by Joos van Craesbeeck titled Man Surprised—on installment payments of $50 per month from his modest $100 monthly income.[34] [33] Lacking formal art historical training, he educated himself through extensive reading and museum visits, later consulting international experts on Northern European art to refine his connoisseurship.[6] [34] His acquisition strategy emphasized undervalued and neglected pieces, often sourcing "dirty old paintings" from antique stores, flea markets, regional auctions, and European dealers, with an annual purchase rate of 100 to 200 works, many requiring restoration.[6] [33] Bader personally cleaned and restored these paintings, leveraging his chemical expertise to remove layers of grime and varnish, thereby uncovering attributions to major artists like Rembrandt and his circle, with a particular focus on biblical and genre scenes from the Dutch Golden Age.[6] [34] Over five decades, this methodical approach built a collection exceeding 500 items, including rediscoveries such as a Rembrandt sold in 1989 for $37.5 million, while he balanced acquisitions with selective sales and donations to institutions like Queen's University's Agnes Etherington Art Centre.[34][33]Key Acquisitions, Exhibitions, and Donations
Bader's key acquisitions emphasized Northern European Old Master paintings, particularly Dutch and Flemish Baroque works, with a focus on Rembrandt van Rijn beginning in the late 1960s.[35] Among his notable purchases was Rembrandt's Portrait of a Man with Arms Akimbo (1658), acquired in 2011 from casino magnate Steve Wynn, who had obtained it at auction two years prior.[36] He also acquired Rembrandt's Head of a Man with Curly Hair (1659), reflecting his discerning approach to authentication and connoisseurship.[37] These purchases contributed to a personal collection exceeding 500 items, including paintings, sculptures, and works on paper from the 14th to mid-19th centuries.[38] Exhibitions of Bader's collection highlighted its depth and scholarly value. The Agnes Etherington Art Centre mounted "Alfred Bader Collects: Celebrating Fifty Years of The Bader Collection" from April 29 to December 3, 2017, showcasing over 200 European paintings with emphasis on Dutch and Flemish artists, including three Rembrandts and Jan Victors's Ruth and Naomi (1653).[39] This marked the semicentennial of his first donation in 1967 and featured recent acquisitions like Bernardo Bellotto's Architectural Capriccio with a Self-Portrait (c. 1762–65).[39] At the Milwaukee Art Museum, "Art, Life, Legacy: Northern European Paintings in the Collection of Isabel and Alfred Bader" opened in fall 2023, presenting loaned works from the collection and underscoring Bader's role as lender to prior shows, such as the 2009 Jan Lievens exhibition.[40][41] Donations formed the cornerstone of Bader's patronage, transforming institutional holdings. To the Agnes Etherington Art Centre, he initiated gifts in 1967 with an early 16th-century painting, followed by Ciro Ferri's Joseph Turning Away from Potiphar’s Wife (c. 1675) in 1973, and multiple Rembrandts, including a second in 2007 and the third (Portrait of a Man with Arms Akimbo) in 2015.[4][42][36] His children later donated a fourth Rembrandt, Head of an Old Man with Curly Hair (1659), in 2019, honoring his legacy and establishing Canada's premier university Old Masters collection.[43] The Milwaukee Art Museum received dozens of works from Bader and his wife Isabel, plus a $4.4 million endowment in 2023 via Bader Philanthropies to bolster European art acquisitions and exhibitions.[40] These contributions elevated the centres' profiles without reliance on less verifiable dealer attributions.[4]Philanthropy and Legacy
Establishment of the Bader Foundation
The Helen Bader Foundation was established in 1992 by Alfred Bader in Milwaukee, Wisconsin, to perpetuate the philanthropic vision of his late first wife, Helen Daniels Bader, who had played a key role in supporting the early operations and expansion of Aldrich Chemical Company alongside her husband.[44][45][46] Funded initially from proceeds of the successful sale of Aldrich Chemical in 1975 and subsequent business ventures, the foundation prioritized grants and program-related investments aimed at enhancing community welfare, with an emphasis on Milwaukee's urban development, arts patronage, Jewish cultural preservation, and social services for underserved populations.[44][47] Alfred Bader served as a primary architect and benefactor, directing resources toward causes aligned with his personal experiences as a Holocaust survivor and chemist, including support for educational initiatives and fine arts acquisitions that later benefited public institutions.[1][45] In subsequent years, the entity incorporated the Isabel and Alfred Bader Fund—named for Alfred's second wife, Isabel—to broaden its scope, culminating in a 2014 restructuring into Bader Philanthropies, Inc., which formalized perpetual operations while committing over $500 million in total funding by the 2020s across local and international programs.[48][44][47]Support for Chemical Education and Research
Bader endowed the Alfred Bader Award in Bioinorganic or Bioorganic Chemistry through the American Chemical Society in 1986, providing a $5,000 prize plus up to $2,500 in travel expenses to recognize outstanding research at the interface of biology and organic or inorganic chemistry.[49] The award, funded by an endowment from Bader and his wife Isabel, supports nominations from professionals in academia, industry, and international settings without restrictions on demographics.[49] From 1986 onward, Bader donated $1.7 million to the ACS Project SEED program, which funds summer research experiences for economically disadvantaged high school students in chemistry laboratories, including $1.3 million specifically for the Alfred & Isabel Bader Scholars initiative that awards $5,000 scholarships to about 20 students each year and has supported 385 scholars to date.[21] His initial 1991 contribution extended the program's duration to a second summer, and he established a bequest from his estate to sustain scholarships for over 30 additional years, emphasizing long-term access to chemistry education for underserved youth.[50][21] Bader directed philanthropy toward his alma mater, Queen's University, where he earned degrees in chemistry, funding research chairs, student financial aid for chemistry students, and a dedicated chemistry symposium in 2004 organized by the department.[51][14] He also underwrote the Aldrichimica Acta journal, which disseminates advancements in organic synthesis and research chemicals to the global chemistry community.[21]Contributions to Arts, Jewish Causes, and Other Initiatives
Bader's contributions to the arts centered on his passion for 17th-century Dutch and Flemish Baroque masters, including Rembrandt. He and his wife Isabel donated hundreds of such artworks to the Agnes Etherington Art Centre at Queen's University, forming a core part of its collection.[52] They also funded the Isabel Bader Centre for the Performing Arts at Queen's University, which opened in 2014 and supports cultural performances and education.[52] In Milwaukee, the Baders donated Northern European paintings to the Milwaukee Art Museum, where they served as advisors and guest curators for exhibitions like The Detective’s Eye in 1989.[1][40] Bader Philanthropies extended this legacy with a $4.4 million gift in 2023, establishing the Isabel and Alfred Bader European Art Program Endowment Fund to support a dedicated curator and exhibitions, including Art, Life, Legacy featuring over 75 Dutch and Flemish masterpieces.[40] Bader supported Jewish causes informed by his experiences as a Holocaust survivor and Kindertransport refugee, emphasizing education and Judaic faith. He established the Helen Bader Scholarship Fund through the Jewish Federation of Milwaukee in 1992, providing $500,000 annually to enhance access to Jewish day schools and totaling over $7.5 million, backed by a $10 million endowment.[52] His philanthropy reflected a commitment to biblical knowledge alongside arts and chemistry.[1] Among other initiatives, Bader donated the 15th-century Herstmonceux Castle in East Sussex, England, to Queen's University, which opened Bader International Study Centre there in 1994 to foster global education.[52] He co-founded the Alfred Bader Fine Arts gallery in Milwaukee in 1961 with Marvin Klitsner, promoting art appreciation.[1] Bader Philanthropies has also funded Alzheimer's research and care in Israel since 2009, supporting organizations like Melabev for elderly community services.[52]