The cardiac index (CI) is a key hemodynamic parameter in cardiology that quantifies cardiac output normalized to an individual's body surface area, offering a standardized measure of heart performance independent of body size.[1] It is calculated by dividing the cardiac output—itself the product of heart rate and stroke volume—by the body surface area, typically yielding values in liters per minute per square meter (L/min/m²).[2] In healthy adults at rest, the normal range for cardiac index is approximately 2.5 to 4.0 L/min/m², though this can vary slightly with age, such as 2.1 to 3.2 L/min/m² in individuals over 60 years.[2] Values below 2.2 L/min/m² often signal impaired cardiac function, potentially indicating conditions like cardiogenic shock.[1]Body surface area is commonly estimated using formulas like the Mosteller equation, which incorporates height and weight: √(height [cm] × weight [kg] / 3600), to ensure the index accounts for physiological variations across patients.[1] Clinically, the cardiac index is vital for evaluating overall circulatory efficiency, distinguishing types of shock (e.g., cardiogenic versus distributive), and guiding therapeutic interventions in critical care settings, such as during anesthesia or in heart failure management.[2] It can be measured invasively via methods like thermodilution with a pulmonary artery catheter or non-invasively through echocardiography, impedance cardiography, or phase-contrast MRI, allowing for broad applicability in both diagnostic and monitoring contexts.[1] Beyond acute care, low cardiac index has been associated with increased risks of dementia and poorer outcomes in organ donation scenarios, underscoring its prognostic value.[1]
Overview
Definition
The cardiac index (CI) is a hemodynamic parameter defined as the cardiac output (CO), which represents the volume of blood pumped by the heart per minute, divided by the body surface area (BSA) of the individual.[1] This normalization yields units of liters per minute per square meter (L/min/m²), allowing for a standardized evaluation of cardiac performance.[2]The primary purpose of the cardiac index is to account for inter-individual differences in body size, such as variations in height and weight, which directly influence absolute CO values.[1] By adjusting CO relative to BSA, CI provides a more precise measure of the heart's efficiency in meeting the body's metabolic demands through adequate tissue perfusion, facilitating comparisons in clinical settings where raw CO might otherwise mislead due to patient physique.[3]The concept of cardiac index was introduced in the early 1930s by physiologists seeking to standardize CO assessments across diverse patients, with foundational work attributed to Arthur Grollman in his 1932 publication on human cardiac output.[4] For example, in a 70 kg adult, CI enables more reliable cross-patient comparisons of cardiac function than unadjusted CO, highlighting relative impairments or enhancements in circulatory adequacy.[5]
Physiological Basis
Cardiac output (CO) represents the total volume of blood ejected by the heart into the systemic circulation per minute and is calculated as the product of stroke volume (SV)—the amount of blood pumped per heartbeat—and heart rate (HR)—the number of beats per minute.[1] This parameter fundamentally quantifies the heart's pumping efficiency and serves as a cornerstone for assessing overall cardiovascular performance.[6]Normalization of cardiac output to body surface area (BSA) yields the cardiac index (CI), which adjusts for inter-individual differences in body size to provide a more standardized measure of cardiac function. Metabolic oxygen demands and tissue perfusion requirements scale with body surface area (reflecting basal metabolic rate), leading to naturally higher absolute CO values in larger individuals; without this adjustment to BSA, comparisons across patients would be confounded by anthropometric variations. BSA is used for normalization because it correlates closely with basal metabolic rate and oxygen consumption requirements, providing a better proxy for physiological demands than body mass alone.[1][3][7]The cardiac index plays a critical physiological role in maintaining adequate systemic perfusion, particularly by ensuring sufficient oxygen delivery to metabolically active tissues throughout the body. Optimal CI levels support the balance between oxygen supply and demand, whereas deviations—such as reduced CI causing tissue hypoperfusion or elevated CI leading to hyperperfusion—can disrupt homeostasis and precipitate organ dysfunction.[1][6]At its core, CI encapsulates the interplay of preload, afterload, and myocardial contractility, regulated by the Frank-Starling mechanism, which enhances stroke volume in response to increased ventricular filling (preload) through greater myofibrillar stretch and calcium sensitivity. Afterload, reflecting the vascular resistance opposing ejection, inversely affects SV, while contractility determines the intrinsic force of myocardial contraction independent of loading conditions; normalization to body surface area allows for a body-size-adjusted evaluation of these integrated factors in sustaining effective circulation.[1][6]
Calculation
Core Formula
The cardiac index (CI) is derived by normalizing cardiac output (CO) to body surface area (BSA), yielding a standardized measure of cardiac performance in liters per minute per square meter (L/min/m²). The primary equation is:\text{CI} = \frac{\text{CO}}{\text{BSA}}This formula adjusts for inter-individual differences in body size, with CO typically expressed in L/min and BSA in m².[1]Cardiac output itself is the product of stroke volume (SV) and heart rate (HR):\text{CO} = \text{SV} \times \text{HR}Here, SV represents the volume of blood ejected by the left ventricle per beat (in liters), and HR denotes the number of beats per minute.[1]The derivation proceeds from CO, which quantifies the heart's total blood pumping capacity per minute, by dividing it by BSA to eliminate the confounding effect of body size on absolute CO values. For instance, a resting adult might have a CO of approximately 5 L/min, and dividing by a typical BSA of 1.7–1.9 m² produces a CI in the range of 2.5–4 L/min/m², facilitating clinical comparisons across patients.[1]Stroke volume is calculated as the difference between end-diastolic volume (EDV), the blood volume in the ventricle at the end of filling, and end-systolic volume (ESV), the residual volume after contraction:\text{SV} = \text{EDV} - \text{ESV}SV normally ranges from 60–100 mL per beat in adults at rest. Heart rate, meanwhile, averages 60–100 beats per minute under similar conditions, modulated by autonomic influences.[8][1]As a practical illustration, consider a patient with CO of 5 L/min and BSA of 1.8 m²:\text{CI} = \frac{5}{1.8} \approx 2.78 \, \text{L/min/m²}This result aligns with normal physiological values, underscoring the formula's utility in assessing cardiac efficiency.[1]
Body Surface Area Methods
Body surface area (BSA) estimation is a critical step in computing the cardiac index, as it normalizes cardiac output to an individual's physical size for inter-patient comparability.[9]The Du Bois formula, developed in 1916, was one of the earliest and remains a foundational method for BSA calculation. It is expressed as:\text{BSA (m²)} = 0.007184 \times \text{weight (kg)}^{0.425} \times \text{height (cm)}^{0.725}This formula was derived from direct measurements of nine cadavers and has been widely adopted due to its empirical basis, though it requires precise height and weight data, which can introduce measurement errors in clinical settings.[10][11]In 1987, Mosteller proposed a simplified formula that prioritizes ease of use while maintaining accuracy, particularly in adults:\text{BSA (m²)} = \sqrt{\frac{\text{height (cm)} \times \text{weight (kg)}}{3600}}This approach eliminates complex exponents, allowing for quicker mental or calculator-based computation, and is preferred in many U.S. clinical protocols for its balance of simplicity and reliability. Like the Du Bois method, it depends on accurate anthropometric measurements, but its square-root structure reduces computational burden without a proportional loss in precision for standard adult populations.[12][9]Comparisons between the Du Bois and Mosteller formulas highlight differences in performance across body types. The Mosteller formula tends to reduce estimation errors in obese patients, where the Du Bois method can underestimate BSA by up to 20% due to its fixed exponents not fully accounting for disproportionate weight gain.[11][13] In normal-weight individuals, both formulas yield comparable results, with mean differences under 0.05 m², but the Mosteller's simplicity offers an advantage in resource-limited environments. However, neither is ideal for extremes of body size, as both assume proportional scaling that may not hold in severe underweight or morbid obesity cases.[14][15]For pediatric patients or individuals at extremes of body size, age-specific variants or alternative formulas are recommended to improve accuracy. The Haycock formula, for instance, adjusts for the higher surface-area-to-volume ratio in children:\text{BSA (m²)} = 0.024265 \times \text{weight (kg)}^{0.5378} \times \text{height (cm)}^{0.3964}This method, validated in neonatal and infant cohorts, better captures growth-related variations compared to adult-oriented formulas like Du Bois or Mosteller, which can overestimate BSA by 10-15% in young children. Such adjustments ensure more precise cardiac index values in vulnerable populations.[9][16]
Normal Values and Interpretation
Standard Ranges
The cardiac index (CI) in healthy adults at rest typically ranges from 2.6 to 4.2 L/min/m², reflecting adequate cardiac output normalized to body surface area for maintaining systemic perfusion under baseline conditions.[17] This range is derived from direct measurements using techniques such as thermodilution during cardiac catheterization in asymptomatic individuals without cardiovascular disease.[1]Values below 2.2 L/min/m² are considered abnormally low and indicative of hypoperfusion, often associated with conditions like heart failure where tissue oxygenation is compromised despite compensatory mechanisms.[18] Conversely, CI values exceeding 4.5 L/min/m² suggest a hyperdynamic state, such as in sepsis, characterized by increased cardiac output due to vasodilation and inflammatory responses.[19]The standard unit for CI is liters per minute per square meter (L/min/m²), ensuring comparability across patients of varying body sizes; values may transiently increase with posture changes (e.g., from supine to upright) or physical activity to meet elevated metabolic demands, but resting thresholds remain the clinical benchmark.[1]These ranges are established from large cohort studies originating in the 1950s, including early cardiac catheterization data on normal hemodynamics, and have been validated in contemporary populations through noninvasive imaging and invasive monitoring in diverse healthy adults.[20][21]
Factors Influencing Values
The cardiac index exhibits notable variations influenced by age, reflecting changes in metabolic rate, heart size, and vascular compliance. In infants and young children, values are typically higher, ranging from 3.5 to 5.5 L/min/m², due to elevated heart rates and oxygen demands associated with growth. As individuals age, cardiac index declines progressively; adults generally maintain ranges of 2.6 to 4.2 L/min/m², while those over 60 years often show reduced means between 2.1 and 3.2 L/min/m², attributed to diminished stroke volume and myocardial efficiency.[22][21]Sex differences in cardiac index are minor and largely stem from variations in body surface area, with males exhibiting slightly higher values owing to greater average BSA. After normalization, cardiac index remains comparable between sexes, though females tend to have lower stroke volume index, indicating relatively reduced absolute output. During pregnancy, cardiac index increases substantially by 30% to 50% above non-pregnant baselines, driven by expanded plasma volume, enhanced venous return, and hormonal adaptations to support fetal circulation.[22][23]Other physiological factors can transiently or persistently alter cardiac index. Exercise induces a temporary elevation in cardiac index, often doubling or more from resting levels, to augment systemic oxygen delivery through increased heart rate and stroke volume. In obesity, standard body surface area formulas, such as the Du Bois equation, may overestimate BSA by up to 15-20%, resulting in underestimation of cardiac index and potential misinterpretation of cardiac performance.[24][25]Ethnic variations in cardiac index are generally minor but evident across populations, with studies reporting differences in baseline values; for example, Asian individuals may show slightly higher or lower means compared to White or Black cohorts, influenced by body composition and genetic factors.[22]
Clinical Applications
Diagnostic Role
The cardiac index (CI) plays a central role in diagnosing systolic dysfunction in heart failure, where a value below 2.2 L/min/m² indicates low-output states and supports the identification of impaired ventricular performance.[1] This threshold, derived from hemodynamic assessments, helps classify patients with acute decompensated heart failure exhibiting signs of tissue hypoperfusion, distinguishing systolic impairment from other etiologies.[26] In clinical practice, CI measurement aids in confirming the diagnosis when combined with elevated filling pressures, as seen in the Forrester classification system for acute myocardial infarction-related heart failure.[27]In shock classification, CI differentiates cardiogenic shock, characterized by a low CI (<2.2 L/min/m²) and high systemic vascular resistance (SVR >1,500 dynes·s·cm⁻⁵·m²), from distributive shock, which features a high or normal CI (>4 L/min/m²) and low SVR (<800 dynes·s·cm⁻⁵·m²).[1] This hemodynamic distinction guides initial diagnostic categorization, as cardiogenic shock reflects primary pump failure leading to inadequate tissue perfusion, whereas distributive forms involve vasodilation and relative hyperdynamic circulation.[28]For specific conditions, CI monitoring assesses perioperative risk, particularly in patients undergoing cardiac surgery, where preoperative low CI values signal heightened vulnerability to complications.[29] In valvular disease, such as low-flow, low-gradient severe aortic stenosis, a reduced CI preoperatively is associated with adverse outcomes following interventions like transcatheter aortic valve replacement, highlighting subclinical left ventricular dysfunction.[30]CI is frequently integrated with SVR and other indices, such as pulmonary capillary wedge pressure, to create comprehensive hemodynamic profiles that refine diagnostic accuracy across cardiac disorders.[31] This combined approach enables precise classification of circulatory failure subtypes, facilitating targeted diagnostic pathways without relying solely on clinical signs.
Prognostic and Therapeutic Uses
The cardiac index (CI) serves as a key prognostic marker in critically ill patients, particularly in intensive care unit (ICU) settings. A low CI, typically below 2.2 L/min/m², is associated with significantly higher mortality rates in conditions such as sepsis and septic shock. For instance, in patients with septic shock, a CI less than 1.85 L/min/m² has been linked to an elevated hazard ratio for mortality compared to intermediate ranges (1.85–2.8 L/min/m²), which correlate with the lowest risk.[32] Similarly, low CI values in severe sepsis are associated with increased risk of ICU mortality, as observed in cohorts where nonsurvivors exhibited markedly lower CI (e.g., 3.6 L/min/m² versus 5.2 L/min/m² in survivors).[33] In heart failure, while baseline CI may not always predict short-term outcomes, persistent low values signal poor prognosis.[1]In advanced heart failure, CI assessment influences transplant candidacy and long-term survival. According to International Society for Heart and Lung Transplantation (ISHLT) guidelines, a CI greater than 2.2 L/min/m², alongside other hemodynamic stability, supports eligibility for heart transplantation by indicating adequate cardiac reserve.[34] Improvement to this threshold through medical optimization can enhance candidacy and reduce waitlist mortality risks. Post-hoc analyses from trials like the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE, 2005) have shown that favorable trends in CI during hospitalization—such as increases above 2.2 L/min/m²—correlate with better 6-month survival and fewer rehospitalizations in decompensated heart failure.[35]Therapeutically, CI guides interventions in shock states to optimize perfusion and outcomes. In septic or cardiogenic shock, protocols target a CI above 2.5 L/min/m² to direct fluid resuscitation, vasopressor titration (e.g., norepinephrine), or inotrope use (e.g., dobutamine if CI remains low despite adequate preload). Mechanical circulatory support, such as intra-aortic balloon pumps or ventricular assist devices, is often initiated when CI falls below 2.2 L/min/m² despite pharmacotherapy, aiming to restore values in the normal range (2.5–4.0 L/min/m²). Surviving Sepsis Campaign guidelines indirectly endorse CI monitoring via surrogates like central venous oxygen saturation, but direct CI targets in protocols like those for cardiogenic shock emphasize >2.2 L/min/m² to mitigate organ dysfunction.[1][36][37]Beyond acute care, chronic low CI has prognostic implications in non-cardiac domains, such as dementia research. Longitudinal studies, including the Framingham Heart Study, demonstrate that a clinically low CI (below 2.5 L/min/m²) is associated with a 55% higher relative risk of incident dementia and accelerated cognitive decline, independent of traditional vascular risk factors, likely due to cerebral hypoperfusion. This correlation underscores CI's role in identifying at-risk populations for preventive interventions.[38]
Measurement Methods
Invasive Approaches
Invasive approaches to measuring cardiac index (CI) involve direct catheterization techniques that provide precise assessments of cardiac output (CO) in critically ill patients, where CI is derived by dividing CO by body surface area (BSA). These methods are typically employed in intensive care units (ICUs) or during high-risk procedures to guide hemodynamic management.The pulmonary artery catheter (PAC), also known as the Swan-Ganz catheter, represents the traditional gold standard for invasive CO measurement via thermodilution. Inserted through a central vein into the pulmonary artery, it allows injection of a cold saline bolus into the right atrium, with temperature changes detected by a thermistor in the pulmonary artery to calculate CO based on the indicator dilution principle; CI is then computed as CO divided by BSA. This method offers high accuracy, with measurement variability typically under 10%, making it reliable for intermittent assessments in unstable patients. However, its use is limited by procedural risks, including arrhythmias (up to 10% incidence), pulmonary artery rupture (rare but fatal at 0.03–0.2%), and infections (1–2% risk), contributing to overall complication rates of 5–10%.[39][40]The Fick method provides another direct invasive technique for CO determination, relying on the principle that CO equals oxygen consumption (VO₂) divided by the arteriovenous oxygen content difference (CaO₂ - CvO₂). It requires simultaneous arterial and mixed venous blood sampling from the pulmonary artery via catheterization, along with measurement of VO₂ using a metabolic cart, to yield CO values that are subsequently used to calculate CI. Considered a reference standard in research settings due to its physiological basis, the Fick method achieves accuracy comparable to thermodilution with limits of agreement of approximately ±20% (or ±1.1 L/min) under steady-state conditions but demands invasive vascular access and is labor-intensive, limiting its routine clinical use.[41][42]Alternative invasive systems, such as lithium dilution and the PiCCO (Pulse Contour Cardiac Output) monitor, enable continuous CO tracking for CI derivation in ICU environments. Lithium dilution involves central venous injection of a lithium chloride bolus, with arterial concentration detected via a peripheral catheter to compute CO through indicator dilution, offering accuracy similar to thermodilution (bias <15%) with fewer complications than PAC. The PiCCO system combines transpulmonary thermodilution—using a central venous injectate and femoral arterial thermistor—with pulse contour analysis for ongoing CO estimation, validated against PAC with limits of agreement within ±20% in critically ill adults. These methods balance precision with reduced invasiveness compared to full PAC deployment but still require arterial and venous access, carrying risks of thrombosis or infection (1–3%).[43][44]Overall, invasive approaches excel in accuracy for high-stakes monitoring but are reserved for select cases due to their inherent risks, with complication profiles underscoring the need for skilled insertion and vigilant post-procedure care.[40]
Noninvasive Approaches
Noninvasive approaches to estimating cardiac index (CI) rely on indirect techniques that avoid catheterization, making them suitable for routine clinical settings, outpatient monitoring, and serial assessments. These methods typically derive stroke volume (SV) from physiological signals or imaging, with CI calculated as (SV × heart rate) / body surface area. They offer advantages in accessibility and reduced procedural risk compared to invasive benchmarks, though they generally exhibit lower precision.Echocardiography, particularly using Doppler ultrasound, is a widely available noninvasive method for CI estimation. It measures SV by assessing aortic blood flow velocity across the left ventricular outflow tract, integrating the velocity-time integral with the outflow tract cross-sectional area. This technique is commonly employed in ambulatory care and intensive settings due to its portability and lack of radiation exposure. Validation studies have demonstrated its correlation with invasive thermodilution measurements, with mean differences in cardiac output typically under 0.5 L/min, though accuracy can vary with operator skill and patient factors like obesity.Bioimpedance cardiography provides a portable, electrode-based approach to SV estimation by detecting changes in thoracic electrical impedance during the cardiac cycle, reflecting blood volume shifts. Electrodes placed on the neck and torso capture these signals to compute SV and thus CI, enabling continuous, real-time monitoring without imaging equipment. This method is particularly useful for serial assessments in heart failure patients or during exercise testing, as devices are lightweight and allow ambulatory use. Comparative analyses show bioimpedance-derived CI values aligning with Doppler echocardiography within 10-15% in stable cohorts.Other noninvasive techniques include inert gas rebreathing, a Fick method variant that uses soluble gases like acetylene to estimate pulmonary blood flow and derive CI without arterial sampling. Bioreactance, an advanced bioimpedance variant, analyzes phase shifts in induced electrical currents for enhanced SV detection during low-flow states. Cardiac magnetic resonance imaging (MRI) offers precise volumetric assessment of SV through cine imaging of ventricular ejection fractions, ideal for research applications requiring high-fidelity data in complex anatomies. These methods have been validated in exercise and critical care contexts, with inert gas rebreathing showing biases below 20% against invasive references.Despite their benefits, noninvasive approaches carry risks of variable accuracy, often with errors of 15-20% relative to invasive standards like pulmonary artery thermodilution, influenced by arrhythmias, lung pathology, or body habitus. They excel in trend monitoring rather than absolute values, with meta-analyses confirming acceptable precision for clinical decision-making in non-critically ill patients.
Limitations
Measurement Errors
The thermodilution method for measuring cardiac output, from which cardiac index is derived, is susceptible to variability particularly in the presence of arrhythmias, where irregular heart rhythms can disrupt the consistent mixing and transit of the injectate through the right heart, leading to errors up to 20% or more in individual measurements.[45] Studies have shown that atrial fibrillation or frequent ventricular ectopy increases the coefficient of variation in thermodilution readings, with percentage errors reaching 35% in arrhythmia subgroups when compared to calibrated reference methods.[46] To address this, clinicians often discard outlier measurements and average multiple boluses, but persistent arrhythmias can still compromise reliability.[47]In noninvasive echocardiography-based approaches, Doppler ultrasound measurements of cardiac output—and thus cardiac index—are highly dependent on the alignment angle between the ultrasound beam and blood flow direction, with deviations greater than 20 degrees causing substantial underestimation of velocity and flow rates.[48] For instance, an angle error of 20 to 30 degrees can introduce inaccuracies exceeding 20% in stroke volume calculations, as the Doppler equation assumes a parallel beam (cosine of 0 degrees = 1), and even small misalignments amplify errors in low-velocity flows like those across mitral or tricuspid valves.[49]Calculation of cardiac index also introduces errors through body surface area (BSA) estimation, especially in edematous patients where fluid retention inflates body weight, leading to overestimated BSA and consequently underestimated cardiac index by 10-15%.[50] In heart failure cohorts with significant edema, standard Du Bois formulas based on height and weight can skew BSA, misclassifying patients with normal cardiac output as having low index values and potentially guiding inappropriate therapy. This issue is compounded in critically ill populations, where accurate anthropometric data may be unavailable or altered by interventions like fluid resuscitation.Inter-method discrepancies further challenge cardiac index validation, as echocardiography often yields values with a small bias compared to thermodilution due to differences in sampling volumes and assumptions about flow profiles, necessitating calibration against invasive references for clinical use.[51] Systematic reviews highlight poor interchangeability between methods, particularly in low-output states.[52] Recent studies from the 2020s advocate hybrid approaches combining noninvasive imaging with minimally invasive calibration, such as pulse contour analysis initialized by echocardiography, to reduce these gaps.[53]Mitigation strategies emphasize repeat measurements to average out random errors, with three to five thermodilution boluses reducing the coefficient of variation below 10% even in unstable patients, and prioritizing trending of serial values over single absolute readings to track hemodynamic changes reliably.[54] In practice, guidelines recommend discarding measurements with >10% inter-bolus variability and focusing on directional trends, which maintain concordance rates above 85% across methods despite absolute discrepancies.[55]
Clinical Constraints
The cardiac index (CI), while valuable for assessing global hemodynamics in acute settings such as shock, has limited utility in chronic stable conditions where patients exhibit compensated perfusion without overt decompensation. In stable heart failure or chronic coronary disease, CI measurements often fail to capture subtle, ongoing adaptations like chronotropic incompetence or mild diastolic dysfunction that do not significantly alter systemic output, rendering it less actionable for routine monitoring compared to symptom-based assessments.[1]A key constraint is that CI provides a global measure of cardiac output normalized to body surface area, overlooking regional perfusion disparities, such as inadequate coronary or renal blood flow in the presence of normal overall values. For instance, in coronary artery disease, focal ischemia may persist despite a CI within normal ranges (typically 2.5–4 L/min/m²), necessitating complementary imaging modalities to evaluate localized hypoperfusion.[56][1]Interpretation of CI can be misleading in conditions affecting oxygen delivery beyond cardiac performance, such as anemia or hypoxia, where hemoglobin levels or arterial oxygenation directly impair tissue oxygenation despite preserved CI. In anemic states, reduced oxygen-carrying capacity lowers systemic oxygen delivery (DO₂), potentially leading to hypoxic tissue injury even with normal CI, as the metric does not account for hemoglobin concentration or PaO₂. Similarly, hypoxic hypoxia from pulmonary issues maintains cardiac output but compromises end-organ oxygenation, highlighting the need for integrated assessment of DO₂ = CI × arterial oxygen content.[57][58]In pediatric contexts, alternatives like stroke volume index (SVI) or left ventricular ejection fraction (LVEF) are often preferred over CI due to greater sensitivity to age-specific ventricular remodeling and growth-related hemodynamic variations. For example, SVI better reflects preload-dependent changes in preterm or congenital heart disease patients, where body surface area normalization in CI may introduce variability during rapid somatic growth.[59][60]Evidence gaps persist regarding CI application across diverse populations, with limited data from non-Western cohorts where genetic, nutritional, and socioeconomic factors may alter baseline values and prognostic thresholds.