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Cyclohexene

Cyclohexene is a cycloalkene with the molecular formula C₆H₁₀, characterized by a six-membered carbon ring containing one carbon-carbon . This structure renders it a key intermediate in , distinguishing it from the fully saturated (C₆H₁₂) by its unsaturation, which imparts reactivity typical of alkenes. As a physical entity, cyclohexene presents as a colorless with a sweet , exhibiting a of 83 °C, a of -103.5 °C, and a of 0.81 g/cm³ at 20 °C. It is insoluble in but highly miscible with common organic solvents such as , , and , reflecting its nonpolar nature. Chemically, it undergoes typical reactions, including electrophilic additions like to or oxidation to form epoxides and diols, and it can participate in Diels-Alder cycloadditions. However, it poses hazards as a highly flammable substance with a of -7 °C and potential to form peroxides upon prolonged exposure to air. Industrially, cyclohexene is produced via partial catalytic of or of . It serves as an intermediate in the production of various chemicals, including precursors for , pharmaceuticals, and polymers, as well as a and gasoline stabilizer. Naturally occurring in , cyclohexene plays a role in and industries.

Structure and Properties

Molecular Structure

Cyclohexene has the C₆H₁₀ and a molecular weight of 82.14 g/mol. It features a six-membered carbon with one endocyclic , distinguishing it from the fully saturated . This unsaturated structure imparts specific geometric constraints that define its chemical identity. The is located between carbons 1 and 2, where these atoms are sp²-hybridized, leading to a planar with a of approximately 120°. This hybridization enforces trigonal planar around the unsaturated carbons, while the remaining four carbons are sp³-hybridized with tetrahedral near 109.5°. The C=C length is approximately 1.34 , shorter than typical C-C single bonds due to the π-component, and the adjacent C-C single bonds (C2-C3 and C1-C6) measure about 1.50 , reflecting partial double-bond character from . At , cyclohexene adopts a half-chair conformation as its most stable form, characterized by C₂ symmetry and a pseudorotation that minimizes torsional strain along the ring. In this arrangement, the and adjacent carbons remain nearly coplanar, while the opposite side of the ring puckers out of plane to avoid eclipsing interactions. This contrasts with the fully relaxed chair conformation of , where all bonds are staggered without such puckering; the in cyclohexene introduces rigidity that prevents a complete chair and enforces the distorted half-chair .

Physical Properties

Cyclohexene is a colorless liquid at with a sweet odor. Its is 0.811 g/cm³ at 20 °C. The is -103.5 °C, and the is 83 °C at standard pressure. Cyclohexene exhibits low in , approximately 0.021 g/100 mL at 25 °C, but is miscible with common organic solvents such as , , acetone, and . Additional physical characteristics include a dynamic of 0.625 mPa·s at 25 °C and a of 1.446 at 20 °C. Key thermodynamic properties are a standard heat of vaporization of 33.5 /mol and a critical of 287 °C. The notably low can be attributed to the flexible half-chair conformation of the molecule, which facilitates disorder in the solid state.
PropertyValueConditionsSource
Density0.811 g/cm³20 °C SDS
Melting point-103.5 °C-
Boiling point83 °C760 mmHg
Water solubility0.021 g/100 mL25 °C
Viscosity0.625 mPa·s25 °C
Refractive index1.44620 °C (D line)
Heat of vaporization33.5 kJ/molStandardNIST
Critical temperature287 °C-

Spectroscopic Properties

The ¹H NMR spectrum of cyclohexene displays three main signals corresponding to the distinct proton environments: the vinylic protons appear as a multiplet at δ 5.6–5.7 ppm (2H), the allylic methylene protons at δ 2.0 ppm (4H, multiplet), and the remaining methylene protons at δ 1.6 ppm (4H, multiplet). These chemical shifts align with the half-chair conformation of the molecule, as the allylic protons are deshielded by the adjacent . The ¹³C NMR spectrum exhibits three signals due to : the olefinic carbons at approximately 127 , the allylic methylene carbons at 25 , and the distal methylene carbons at 23 . () spectroscopy reveals characteristic absorptions for the functionality, including the C=C stretching vibration at 1640 cm⁻¹ (medium intensity) and =C–H stretching at 3000–3100 cm⁻¹ (medium), alongside aliphatic C–H stretches at 2850–2950 cm⁻¹; notably, no bands appear for O–H or C=O groups, confirming the absence of oxygen-containing functionalities. Ultraviolet-visible (UV-Vis) shows an absorption maximum at approximately 180 nm (ε ≈ 7000 M⁻¹ cm⁻¹), attributed to the π→π* transition of the isolated carbon-carbon . of cyclohexene yields a molecular peak at m/z 82 (weak), with the base peak at m/z 54 arising from the loss of (C₂H₄) to form the C₄H₆⁺ fragment; other prominent ions include m/z 67 (C₅H₇⁺) and m/z 41 (C₃H₅⁺).

Synthesis

Industrial Production

The primary industrial production of cyclohexene involves the partial catalytic hydrogenation of benzene, a process that selectively adds one equivalent of hydrogen to form the alkene while minimizing over-hydrogenation to cyclohexane. This method utilizes ruthenium-based catalysts, typically modified with zinc (e.g., Ru-Zn on supports like ZrO2 or carbon), in the presence of promoters such as ZnSO4 to enhance selectivity by facilitating the desorption of cyclohexene from the catalyst surface. Reaction conditions generally include temperatures of 100–150 °C and hydrogen pressures of 40–60 bar, achieving cyclohexene selectivities of 50–80% and yields up to 60% in optimized systems. A landmark implementation is the Asahi Chemical (now ) process, developed in the 1980s and commercialized with Japan's first plant in 1990, featuring a capacity of 60,000 tons per year. This slurry-phase process employs agitated multiphase reactors containing , , as a , and the Ru-Zn suspension, followed by to recycle unreacted and while isolating the organic product stream containing cyclohexene and byproducts. The design emphasizes economic efficiency through high selectivity and catalyst stability, with serving as a valuable coproduct for further use in production. Global cyclohexene production supplies downstream chemicals like and precursors, with major facilities concentrated in (led by ) and . Purification of crude cyclohexene from the mixture is challenging due to the close boiling points of the components— at 80.1 °C, at 80.7 °C, and cyclohexene at 82.5 °C—requiring multi-stage under reduced pressure or with solvents like N-methylpyrrolidone to achieve high purity (>99%). This step ensures the product meets specifications for subsequent industrial applications.

Laboratory Preparation

One common laboratory method for preparing cyclohexene involves the dehydration of using an acid catalyst such as concentrated or at temperatures of 160-180°C. This reaction proceeds via an E1 mechanism, where the alcohol is first protonated, followed by loss of water to form a intermediate, and subsequent to yield the . The balanced equation for the reaction is: \ce{C6H11OH ->[H2SO4 or H3PO4][160-180^\circ C] [C6H10](/page/C6H10) + H2O} Yields typically range from 70-80% under optimized conditions in educational and settings. Alternative routes for small-scale synthesis include the partial reduction of . This can be achieved using sodium in liquid , though it often favors 1,4-cyclohexadiene as the primary product, or via catalytic with poisoned catalysts modified for aromatic systems, suitable for trace quantities in applications. Another practical method is the of 1,2-dibromocyclohexane using dust in or sodium iodide in acetone, which eliminates the vicinal bromines to form the stereospecifically from the isomer. This approach is particularly useful in teaching anti-elimination mechanisms and provides cyclohexene in moderate yields. Following synthesis, cyclohexene is isolated by under reduced pressure (typically at 40-50°C and ~100 mmHg) to minimize thermal , followed by washing with aqueous to remove acidic impurities and drying over anhydrous .

Chemical Reactions

Electrophilic Addition Reactions

Cyclohexene, as a symmetrical cycloalkene, undergoes reactions at its carbon-carbon , where an attacks the π electrons, leading to the formation of new σ bonds and saturation of the . These reactions exemplify the general reactivity of alkenes and are influenced by the cyclic , which imposes stereochemical constraints on the products. One prominent example is , particularly with in , which proceeds via an anti involving a cyclic bromonium intermediate. The electrophilic Br⁺ from Br₂ bridges the carbons, forming a three-membered ring, followed by nucleophilic attack by Br⁻ from the opposite face, yielding trans-1,2-dibromocyclohexane as a of enantiomers. The overall reaction is represented as: \ce{C6H10 + Br2 -> C6H10Br2} This stereospecific anti is a direct consequence of the bromonium pathway, preventing products. Hydrogenation of cyclohexene involves the catalytic addition of hydrogen gas, typically using palladium on carbon (Pd/C) as a heterogeneous catalyst under mild pressure and temperature conditions, resulting in the formation of cyclohexane. This syn addition process saturates the double bond without generating stereocenters in the product due to the symmetry of the resulting alkane. The reaction equation is: \ce{C6H10 + H2 ->[Pd/C] C6H12} The efficiency of this transformation highlights cyclohexene's utility in model studies of catalytic hydrogenation. In , cyclohexene reacts with (HCl) in an that follows , where the adds to one carbon of the and the to the other, producing chlorocyclohexane. Since the alkene is symmetrical, only one regioisomer forms, proceeding via a intermediate at the secondary carbon. The yields a due to the planar allowing attack from either face. The reaction is: \ce{C6H10 + HCl -> C6H11Cl} This addition is regioselectively dictated by the stability of the intermediate , though symmetry eliminates regiochemical ambiguity. Acid-catalyzed hydration of cyclohexene employs dilute or similar to facilitate the addition of water across the , forming through a mechanism. The of the generates a secondary , which is then trapped by water as a , followed by . Due to the cyclic structure and planarity, the product is a racemic with no specific imposed beyond the ring's constraints. The equation is: \ce{C6H10 + H2O ->[H2SO4] C6H11OH} This reaction underscores the reversibility of alcohol-alkene interconversions under acidic conditions. Overall, the in these additions to cyclohexene favors products in cases like due to the approach enabled by the ring's , while carbocation-mediated processes like and produce mixtures without diastereoselectivity.

Oxidation and Rearrangement Reactions

Cyclohexene undergoes epoxidation with peracids such as (mCPBA), yielding cyclohexene oxide through a concerted, stereospecific addition that preserves the alkene's . This transformation breaks the C=C π-bond while forming two new C-O bonds in a three-membered ring. The reaction is represented as: \ce{C6H10 + mCPBA -> C6H10O} where C₆H₁₀O denotes the epoxide. Oxidative cleavage of the double bond in cyclohexene proceeds via ozonolysis, where ozone adds across the alkene to form an initial ozonide that decomposes to a carbonyl oxide intermediate; a subsequent reductive workup with dimethyl sulfide or zinc/acetic acid yields hexanedial (adipaldehyde). Alternatively, hot, acidic potassium permanganate (KMnO₄) cleaves the double bond to produce adipic acid (hexanedioic acid), a key intermediate in nylon-6,6 synthesis. This oxidative process involves syn dihydroxylation followed by further oxidation of the diol to the dicarboxylic acid. Allylic oxidation targets the hydrogens adjacent to the in cyclohexene. Treatment with (SeO₂) in dioxane or selectively oxidizes the allylic methylene group, forming 2-cyclohexen-1-ol as the major product after of the initial allylic seleninic ester intermediate. Similarly, N-bromosuccinimide (NBS) under radical conditions (light or peroxides) performs allylic bromination, yielding 3-bromocyclohexene via abstraction of the allylic hydrogen and subsequent bromination, with the double bond often migrating due to in the allylic radical. Olefin metathesis of cyclohexene employs ruthenium-based catalysts to facilitate ring-opening metathesis (ROMP), generating and poly(cyclohexenylene) through repeated [2+2] cycloadditions and exchanges. This reaction is driven by the release of gaseous , allowing high conversions under mild conditions. Under acid-catalyzed conditions, such as with zeolite-based catalysts like H-Beta or sulfated zirconia, cyclohexene undergoes skeletal rearrangement to methylcyclopentene via of the double bond, followed by migration and , favoring the more stable five-membered ring product. This achieves high selectivity (up to 96%) at moderate temperatures (around 200°C), highlighting the role of Brønsted acid sites in promoting ring contraction.

Applications

Industrial Uses

Cyclohexene can serve as a chemical in the production of precursors, such as through oxidative cleavage methods like followed by oxidative workup. is essential for synthesis via polycondensation with , supporting a global production capacity of approximately 3.7 million metric tons annually as of 2023. Additionally, cyclohexene acts as an intermediate in manufacturing, a for nylon-6. The process involves selective oxidation of cyclohexene to , followed by oximation and to form the ring. Although the dominant industrial route to starts from , the cyclohexene pathway contributes to the overall global capacity of about 9.5 million metric tons per year as of 2024, driven by demand in textiles and plastics. Beyond synthetic intermediates, cyclohexene functions as a nonpolar in various applications. It is employed in the of paints, varnishes, and resins due to its ability to dissolve nonpolar substances effectively, and in processes to isolate fats and oils from natural sources. These uses leverage cyclohexene's low and , making it suitable for cleaning and purification in chemical processing. Cyclohexene also participates in Diels-Alder cycloadditions with derivatives of and to produce cyclic adducts, which serve as building blocks in the synthesis of maleic anhydride-based polymers and resins. These reactions enable the formation of bicyclic structures used in unsaturated production for composites and coatings.

Research and Pharmaceutical Applications

Cyclohexene is widely employed as a model compound in on reactivity, particularly within organometallic , due to its cyclic structure that facilitates the study of and reaction mechanisms. In investigations, its ring-opening metathesis polymerization (ROMP) has been studied to evaluate advanced catalyst performance, such as ruthenium-based systems, under challenging conditions due to low , enabling insights into initiation, propagation, and termination steps. This application highlights cyclohexene's role in advancing catalysts for precise carbon-carbon rearrangements, with studies demonstrating high conversion rates and polymer molecular weights exceeding 10^5 g/mol in optimized setups. As a precursor in the of natural products, cyclohexene participates in ring-opening metathesis reactions to construct complex frameworks, notably for where the cyclohexene moiety in monoterpenes undergoes metathesis with to yield linear dienes as synthetic intermediates. This approach has been instrumental in transforming cyclic terpenoids into acyclic precursors, achieving yields up to 80% while preserving essential for bioactivity. For steroids, analogous metathesis strategies utilize cyclohexene derivatives to form the requisite six-membered rings, integrating seamlessly into multi-step sequences that mimic biosynthetic pathways. In pharmaceutical applications, cyclohexene serves as a key intermediate, with its derivative (cyclohexene oxide) undergoing to produce trans-1,2-cyclohexanediol, a versatile building block for drug synthesis. Similarly, for analgesics, cyclohexene-derived cyclohexyl groups feature in non-opioid structures, such as cyclohexyl-N-acylhydrazones, that enhance and pain-relieving efficacy, with studies showing reduced comparable to standard agents. Beyond pharmaceuticals, cyclohexene finds use in polymer chemistry through copolymerization with styrene, yielding specialty rubbers with tailored elasticity and thermal stability via metallocene-MAO initiator systems. These copolymers exhibit alternating microstructures that improve mechanical properties, such as tensile strength above 20 MPa, making them suitable for niche applications like vibration-dampening materials. Recent post-2020 developments emphasize , where cyclohexene is oxidized directly to using over heterogeneous catalysts, offering a nitric acid-free route with over 90% selectivity and reduced waste compared to traditional processes. As of 2025, pilot-scale continuous-flow processes for this sustainable pathway have been demonstrated, supporting production of for resins from renewable feedstocks.

Safety and Environmental Impact

Health and Toxicity

Cyclohexene is classified under the Globally Harmonized System (GHS) as a (category 1, H225), an aspiration hazard (category 1, H304), and an irritant to skin (category 2, H315), eyes (category 2B, H319), and (STOT SE 3, H335). Acute exposure to cyclohexene can cause to the skin, eyes, and , with defatting of the skin leading to dryness or cracking upon prolonged contact. The oral LD50 in rats is approximately 1940 mg/kg, indicating low to moderate by this route. Dermal LD50 values exceed 200 mg/kg in rabbits, suggesting limited absorption through the skin. Inhalation of cyclohexene vapors at high concentrations (>1000 ppm) may produce effects, including , , and . The LC50 for in rats is greater than 6370 ppm over 4 hours, reflecting low acute . Chronic exposure to cyclohexene has been associated with potential liver damage, such as increased incidence of hepatis, and kidney effects, including in male rats at concentrations of 720 mg/m³ or higher via . Chronic studies in rats and mice showed no carcinogenic effects. No significant was observed in studies up to 500 mg/kg-day orally. Occupational exposure limits for cyclohexene include an OSHA (PEL) of 300 (1015 mg/m³) as an 8-hour time-weighted average (). The National Institute for Occupational Safety and Health (NIOSH) recommends the same REL of 300 , while the American Conference of Governmental Industrial Hygienists (ACGIH) sets a (TLV) of 20 . The immediately dangerous to life or health (IDLH) concentration is 2000 . First aid measures for cyclohexene exposure include moving affected individuals to for incidents and monitoring for respiratory distress; washing skin with soap and water for contact, followed by seeking attention if persists; and flushing eyes with water for 15 minutes if splashed. For , do not induce vomiting due to risk, and seek immediate help.

Environmental Considerations

Cyclohexene exhibits limited biodegradability in aquatic environments. According to OECD Guideline 301C (Modified MITI Test (I)), no biodegradation was observed after 28 days, with 0% biochemical oxygen demand (BOD) achieved, indicating it is not readily biodegradable. Despite this, cyclohexene demonstrates acute toxicity to aquatic organisms, with an LC50 value of 7.1 mg/L for guppies (Poecilia reticulata) after 96 hours of exposure, classifying it as toxic to aquatic life with potential for long-term adverse effects. The compound has a low potential for due to its (log Kow) of approximately 2.99, which suggests moderate hydrophobicity but limited uptake in organisms. Supporting factor (BCF) data range from >12 to <38, confirming minimal persistence and accumulation in soil or water compartments, as it partitions preferentially into air or sediments rather than biological tissues. As a (), cyclohexene contributes to the formation of and photochemical through atmospheric reactions with hydroxyl radicals. Its emissions are regulated under the U.S. Agency's Clean Air Act, which mandates control measures for VOCs from industrial sources to mitigate air quality impacts, including national emission standards for hazardous air pollutants where applicable. Industrial waste management for cyclohexene involves treatment as , with recommended for disposal to ensure complete combustion and minimize environmental release, while is feasible for uncontaminated streams in chemical facilities. Spills should be absorbed using inert materials such as or to prevent entry into waterways, followed by collection and proper disposal. Efforts toward sustainability include emerging bio-based production routes for cyclohexene, such as chemo-enzymatic cascades starting from renewable feedstocks like derived from vegetable oils, which reduce reliance on petroleum-derived and lower the overall ; these methods have been explored as part of broader initiatives.

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    Nov 7, 2019 · Cyclohexene and cyclopentene are produced from oleic acid via either a six- or eight-step enzyme cascade involving hydration, oxidation, ...<|control11|><|separator|>