Octanol-water partition coefficient
The octanol-water partition coefficient, denoted as Kow or Pow, is a physicochemical parameter that quantifies the distribution of a neutral substance between two immiscible liquid phases—n-octanol and water—at equilibrium and a specified temperature, typically 25°C. It is defined as the ratio of the concentration of the substance in the n-octanol phase (Co) to its concentration in the water phase (Cw), expressed mathematically as Kow = Co / Cw, and is a dimensionless value usually reported on a logarithmic scale as log Kow to span its wide range from hydrophilic (log Kow < 0) to highly lipophilic compounds (log Kow > 6).[1] n-Octanol serves as a surrogate for lipid membranes and organic matter due to its amphiphilic nature, making Kow a reliable indicator of a compound's hydrophobicity or lipophilicity.[2] This coefficient plays a pivotal role in multiple scientific and regulatory domains, particularly in predicting the environmental fate and biological interactions of organic chemicals. In environmental science, log Kow is essential for modeling partitioning behaviors, such as sorption to soils and sediments, volatilization, and bioconcentration in aquatic organisms, where values exceeding 4 often signal potential bioaccumulation risks under frameworks like REACH.[3] In pharmacology and drug design, it informs absorption, distribution, metabolism, and excretion (ADME) profiles by correlating with membrane permeability, solubility, and bioavailability, with optimal oral drug candidates typically exhibiting log Kow values between 1 and 3.[4] Quantitative structure-activity relationship (QSAR) models further leverage Kow to estimate toxicity and ecotoxicological endpoints without extensive testing.[2] Measurement of Kow follows standardized protocols to ensure accuracy, especially for compounds with extreme values. The OECD Test No. 123 slow-stirring method is preferred for highly hydrophobic substances (log Kow up to 8.2), involving equilibration in a stirred reactor to minimize emulsion formation, followed by concentration analysis via techniques like high-performance liquid chromatography (HPLC) or gas chromatography.[1] For volatile or low-solubility compounds, chromatographic methods—such as reversed-phase HPLC or gas-liquid chromatography—offer efficient alternatives by correlating retention times to partition behavior at infinite dilution.[5] These approaches, validated against direct shake-flask equilibration, support reliable data for regulatory submissions and predictive modeling.[2]Fundamentals
Definition
The octanol-water partition coefficient, commonly denoted as P or K_{ow}, is defined as the ratio of the equilibrium concentration of a neutral organic compound in the 1-octanol phase to its concentration in the water phase, expressed asP = \frac{[\text{solute}]_{\text{octanol}}}{[\text{solute}]_{\text{water}}}
This parameter is measured under standard conditions of 25°C and pH 7 to ensure applicability to non-ionizable, neutral species.[6][7][1] Due to the wide range of values typically encountered, the coefficient is often reported on a logarithmic scale as \log P or \log K_{ow}, providing a measure of the compound's lipophilicity.[8][9] The selection of 1-octanol as the organic phase stems from its amphiphilic properties—a polar hydroxyl group attached to a hydrophobic alkyl chain—which effectively mimic the structure of phospholipid bilayers in biological membranes.[10]
Physical and Chemical Significance
The octanol-water partition coefficient P (or its logarithm \log P) serves as a fundamental descriptor of a molecule's lipophilicity, quantifying its relative affinity for a nonpolar organic phase versus an aqueous phase. A high \log P value, typically greater than 0, indicates that the solute predominantly partitions into the octanol phase, reflecting dominant hydrophobic interactions that favor nonpolar environments. Conversely, a low \log P value, often below 0, signifies hydrophilic behavior, where the molecule prefers the water phase due to stronger polar interactions with water molecules.[7] This partitioning arises from differences in intermolecular forces between the two solvents. In water, polar solutes engage in extensive hydrogen bonding and electrostatic interactions, leading to favorable solvation through ordered water structures around hydrophilic groups. Octanol, being less polar with a longer hydrocarbon chain, promotes van der Waals dispersion forces and weaker hydrogen bonding (facilitated by its hydroxyl group and residual water content of about 2.3 M at saturation), which better accommodate nonpolar moieties. The balance of these forces—hydrophobic effects driving exclusion from water, alongside solvation energies—determines the free energy of transfer, with each additional methylene group in homologous series increasing P by approximately a factor of 3 due to enhanced van der Waals contributions.[11] Octanol's amphiphilic structure, combining a polar head and nonpolar tail, positions it as a biomimetic model for lipid bilayers and cell membranes, capturing essential aspects of membrane partitioning without the complexity of actual biological systems. This analogy stems from octanol's ability to simulate the hydrophobic core and interfacial hydrogen-bonding sites of phospholipid bilayers, allowing \log P to reflect molecular tendencies toward membrane integration.[12] The coefficient is dimensionless, expressed as the ratio of concentrations at equilibrium, with \log P values commonly spanning -3 for highly hydrophilic compounds (e.g., simple polyols) to +7 for very lipophilic ones (e.g., long-chain hydrocarbons), encompassing most environmentally and biologically relevant molecules.[7]Historical Development
Early Concepts
The origins of the octanol-water partition coefficient trace back to 19th-century investigations into solute distribution between immiscible solvents, formalized by Walther Nernst's distribution law in 1891. Nernst demonstrated that, at constant temperature, a solute distributes itself between two non-miscible phases such that the ratio of its concentrations in the two phases remains constant, assuming the solute is in the same molecular form in both.[13] This principle, illustrated through experiments with benzoic acid partitioning between water and benzene while accounting for factors like dimerization and ionization, provided the thermodynamic basis for equilibrium partitioning and influenced subsequent studies on solubility and phase transfer.[13] Early 20th-century research extended these ideas to biological contexts, particularly in understanding narcosis and membrane interactions. In 1899, Hans Horst Meyer examined the narcotic effects of organic compounds on tadpoles, finding that their potency correlated directly with their partitioning into olive oil from water; independently, Charles Ernest Overton reached similar conclusions in 1901.[13] This work, part of the emerging lipoid theory of narcosis, highlighted how oil-water partition coefficients could predict a compound's ability to cross biological barriers, with higher coefficients indicating greater membrane permeability and biological activity.[14] Before octanol became prominent, early lipophilicity assessments relied on analog solvents to model hydrophobic environments. Olive oil was frequently used as a proxy for biological lipids in narcosis studies by Meyer and contemporaries, offering a natural, complex phase that approximated cellular membranes.[13] Chloroform, meanwhile, served in distribution experiments for solutes like carboxylic acids, revealing wide ranges in partition behavior influenced by ionization and solvent interactions.[13] In the 1930s, Runar Collander and Harald Bärlund conducted experiments on the alga Chara ceratophylla, measuring the penetration rates of non-electrolytes and correlating these with their distribution coefficients across various solvent pairs, such as olive oil-water and chloroform-water.[15] In 1951, Collander further investigated the partitioning of organic compounds between higher alcohols, including n-octanol, and water, demonstrating that n-octanol-water partitioning effectively predicted passive diffusion through biological membranes due to its amphiphilic nature mimicking lipid interfaces.[16]Standardization and Evolution
In the mid-20th century, the octanol-water system emerged as the preferred model for assessing lipophilicity in medicinal chemistry, largely due to the pioneering efforts of Corwin Hansch and Toshio Fujita. Their 1964 publication introduced the hydrophobic substituent constant π, calculated from differences in n-octanol-water partition coefficients (log P), which enabled systematic quantitative structure-activity relationship (QSAR) analyses for correlating chemical structure with biological activity. This adoption of n-octanol over earlier solvents like chloroform or olive oil standardized the measurement, as its amphiphilic nature—featuring a polar hydroxyl group and a nonpolar hydrocarbon chain—better simulated interactions with biological membranes.[17] International standardization accelerated in the late 20th century through regulatory frameworks. The Organisation for Economic Co-operation and Development (OECD) adopted Test Guideline 107 in 1981, detailing the shake-flask method for direct measurement of log P values typically between -2 and 4, ensuring reproducible experimental conditions across laboratories. This was expanded in 1989 with Test Guideline 117, which incorporated high-performance liquid chromatography (HPLC) for estimating log P up to 6, offering greater efficiency for volatile or low-solubility compounds while maintaining comparability to shake-flask results. These guidelines established n-octanol-water partitioning as a core physicochemical parameter in chemical safety assessments. The 1970s and 1980s saw refinements addressing limitations for ionizable compounds, where partitioning varies with pH due to protonation states. Albert Leo, Corwin Hansch, and David Elkins formalized the distinction in their 1971 review, defining the distribution coefficient (log D) as the pH-dependent ratio of total analyte concentrations in octanol and aqueous phases, contrasting it with log P for the neutral form. This evolution improved QSAR applicability in pharmacology, recognizing that physiological pH (around 7.4) often results in mixed ionization, thus log D provides a more realistic metric for bioavailability predictions. Recent decades have focused on methodological enhancements and sustainability. The 2000s introduced high-throughput shake-flask and HPLC variants, automating measurements for hundreds of compounds daily to support rapid drug screening, with accuracies comparable to traditional methods. In the 2020s, efforts have shifted toward eco-friendly alternatives to n-octanol, such as hydrophobic deep eutectic solvents and biomimetic systems like liposomes or phospholipid membranes, which reduce volatile organic compound use while offering partitioning data more aligned with cellular environments.[18][3]Experimental Determination
Methods of Measurement
The primary experimental methods for determining the octanol-water partition coefficient (log Pow) rely on achieving equilibrium between the two immiscible phases and quantifying the solute concentrations in each. These techniques are standardized by organizations such as the OECD to ensure reproducibility and accuracy for substances spanning a range of hydrophobicities. The choice of method depends on the compound's solubility, volatility, and log Pow value, with direct partitioning approaches preferred for validation against computational estimates. The shake-flask method, outlined in OECD Test Guideline 107, is the traditional reference technique for measuring log Pow values typically between -2 and 4. It involves preparing mutually saturated n-octanol and water phases, adding the test substance to the mixture in a separatory funnel or centrifuge tube, and shaking vigorously (e.g., 100 oscillations over 5 minutes at 20-25°C) to reach equilibrium, followed by phase separation via centrifugation. Concentrations are then analyzed in both phases using techniques such as UV-Vis spectrophotometry, gas chromatography (GC), or high-performance liquid chromatography (HPLC), ensuring minimal cross-contamination during sampling. The partition coefficient is calculated as the ratio of the solute concentration in the octanol phase ([C]oct) to that in the water phase ([C]water), expressed as log Pow = log([C]oct/[C]water). Duplicate or triplicate runs with varying phase volume ratios are performed to verify consistency, with results within ±0.3 log units considered acceptable.[19] For compounds with log Pow values between 0 and 6, the HPLC correlation method (OECD Test Guideline 117) provides an efficient alternative by indirectly estimating log Pow through chromatographic retention behavior. The test substance is injected into a reverse-phase HPLC system equipped with a C8 or C18 silica column and a mobile phase of methanol-water (e.g., 75:25 v/v), using UV detection at 210 nm. Retention times (tR) are measured relative to the dead time (t0), yielding the capacity factor k = (tR - t0)/t0. This is correlated via linear regression (log Pow = a + b log k) against 6-10 reference standards with known log Pow values that bracket the test compound's expected range, such as acetophenone (log Pow = 2.38) and DDT (log Pow = 6.19). The method requires a correlation coefficient of at least 0.9 and is unsuitable for strongly ionizable or surface-active substances without pH buffering.[20] For highly hydrophobic compounds with low water solubility (log Pow > 5), the slow-stirring method (OECD Test Guideline 123) minimizes artifacts from emulsion formation by using gentle agitation in a large-volume reactor. Mutually saturated n-octanol and water phases (e.g., 1:10 volume ratio) are combined with the test substance dissolved in octanol, then stirred at low speed (creating a 0.5-2.5 cm vortex) for up to 144 hours at 25°C until equilibrium is confirmed by stable concentration ratios over time. Samples from each phase are analyzed by HPLC or GC, with the method particularly effective for substances like polychlorinated biphenyls where traditional shaking risks overestimation due to octanol microdroplets in water. Similarly, the generator-column technique, as described in EPA OPPTS 830.7560 and TSCA §799.6756, employs a dynamic flow system for log Pow values of 1-6. A generator column packed with silanized diatomaceous earth coated in 1% (w/w) test substance in n-octanol is equilibrated with flowing water at 1 mL/min for 15 minutes at 25°C; the effluent aqueous concentration is measured by HPLC or GC after extraction, allowing calculation from the phase ratio without direct phase separation. This approach suits volatile or low-solubility compounds by generating saturated solutions continuously.[21][22] pH-dependent variants address ionizable compounds by measuring the distribution coefficient (log D), which accounts for speciation. These adaptations, often based on the shake-flask or slow-stirring methods, use buffered aqueous phases (e.g., phosphate buffer at pH 7.4) to maintain a specific pH, with equilibrium partitioning and analysis proceeding as in the parent techniques. Log D is calculated analogously to log Pow but reflects the total (ionized + neutral) solute distribution, enabling assessment at physiological or environmental pH values; for instance, weak acids show decreased log D at high pH due to ionization favoring the aqueous phase.[23]Sources of Error and Limitations
Experimental determination of the octanol-water partition coefficient (Kow) is susceptible to several common sources of error that can compromise accuracy. Emulsion formation, particularly during vigorous shaking in the shake-flask method, often results in small octanol droplets contaminating the aqueous phase, leading to overestimated water concentrations and underestimated log Kow values, especially for compounds with log Kow > 6.[24] Incomplete equilibration poses another challenge, as achieving true partition equilibrium may require hours to days depending on the compound, with insufficient agitation time causing persistent inaccuracies in traditional shake-flask approaches, which become unreliable for log Kow > 4–5 due to microemulsion risks.[24] Volatility losses of solutes during handling or analysis further contribute to errors, particularly for more volatile compounds, by reducing measured concentrations in both phases.[25] To mitigate these issues, the slow-stirring method is recommended, as it minimizes emulsion formation and interfacial effects; inter-laboratory ring tests using this approach have demonstrated variability of less than 1 log unit across 15 labs.[24][26] Certain compound classes present inherent limitations in Kow measurement. For ionizable species such as acids or bases, the partition coefficient is highly pH-dependent, as ionization shifts the distribution toward the aqueous phase (log D < log P), with measurements requiring control at specific pH values to reflect neutral forms; for instance, log D can vary significantly across pH 1–13 for pharmaceuticals.[27][28] Highly lipophilic compounds with log Kow > 5 suffer from extremely low aqueous solubility (< 10−5 M), resulting in analytical challenges like detection limits and phase separation difficulties, often necessitating alternative methods like generator columns but still yielding higher uncertainties.[29] Surfactants introduce additional interference due to their amphiphilic nature, promoting aggregation at interfaces and emulsification that obscures true partitioning, rendering standard shake-flask measurements impractical without modifications like sample evaporation and redissolution to eliminate octanol effects.[30][31] Environmental factors like temperature and ionic strength also affect measurement reliability. Standard conditions specify 25°C to ensure comparability, but deviations alter Kow; for example, increasing temperature from 25°C to 45°C decreases log Kow by approximately 0.24 units for bisphenol A, equating to a 2–3% change in Kow per °C due to enhanced solute solubility in water.[32] Elevated ionic strength, such as from salinity (0.5–50 psu), can slightly increase log Kow by 0.1–0.2 units through the salting-out effect, though this is less pronounced than temperature influences.[32] Reproducibility remains a key limitation, with inter-laboratory variability often reaching up to 0.5 log units due to differences in protocols, equipment, and analyst expertise, as accepted under OECD Test Guideline 117 for high-performance liquid chromatography methods.[3] Recent 2025 analyses of consolidated datasets, integrating multiple experimental and predictive methods for over 170 chemicals, have shown that combining at least five independent estimates reduces this variability to within 0.2–0.3 log units, enhancing overall accuracy for environmental and regulatory applications.[3]Computational Estimation
Empirical and QSAR Methods
Empirical methods for estimating the octanol-water partition coefficient (log P) rely on additive contributions from molecular fragments or substituents, derived from experimental data on known compounds. These approaches assume that the overall lipophilicity can be calculated by summing the hydrophobic or hydrophilic contributions of individual structural units, often with corrections for intramolecular interactions. One seminal fragment-additive method, introduced by Leo, Hansch, and Elkins, calculates log P as the sum of fragment values plus correction factors: \log P = \sum f_i + \sum F_j where f_i represents the contribution of each fragment and F_j accounts for electronic or steric effects that alter additivity.[13] This method, foundational to tools like CLOGP developed by Hansch and Leo in 1971, uses atomic and group constants calibrated against a database of measured log P values to predict lipophilicity for new molecules.[13] Quantitative structure-activity relationship (QSAR) models extend these empirical techniques by employing linear free energy relationships (LFER) to correlate log P with molecular descriptors. Hansch analysis, a cornerstone of QSAR, applies multiple linear regression to relate biological or physicochemical properties to parameters such as log P, substituent constants (π for hydrophobicity), and steric factors (Es). For log P estimation specifically, these models often regress against descriptors like molecular weight and polar surface area, yielding equations of the form \log P = a \cdot MW + b \cdot PSA + c, where coefficients are fitted to training data.[33] This approach, pioneered in the 1960s and refined in subsequent works, enables predictive modeling by capturing how structural variations influence partitioning behavior.[13] Commercial software implements these empirical and QSAR methods for practical log P prediction. ACD/LogP, for instance, employs a fragment-based classic algorithm trained on over 12,000 experimental values, supplemented by the GALAS method that adjusts predictions based on structural similarity to a larger dataset of more than 22,000 compounds; it achieves accuracy within approximately 0.5 log units for compounds in its training space.[34] Similarly, the KOWWIN module in EPA's EPI Suite uses a fragment-constant approach, assigning coefficients to atomic fragments and larger groups derived from a training set of around 10,000 compounds, with reported root-mean-square errors of about 0.4 log units on validation data.[35] These tools prioritize speed and broad applicability for screening in drug design and environmental assessments. Despite their utility, empirical and QSAR methods have notable limitations, particularly for compounds with novel scaffolds or underrepresented functional groups in training sets, where predictions can deviate significantly due to unaccounted interactions.[36] Flexible molecules often face overestimation of log P, as additive models struggle to capture conformational effects that influence solvation.[37] Validation against experimental data remains essential to assess reliability for specific chemical classes.Advanced Computational Approaches
Advanced computational approaches for predicting the octanol-water partition coefficient (log P) leverage quantum mechanical calculations, molecular dynamics simulations, and machine learning techniques to achieve higher accuracy and mechanistic insight compared to empirical methods. These methods focus on ab initio computations of solvation free energies or data-driven models trained on extensive datasets, enabling predictions for diverse chemical structures without relying on predefined descriptors. Quantum mechanical methods, such as the Conductor-like Screening Model for Realistic Solvents (COSMO-RS), provide a predictive framework for solvation free energies in octanol and water, directly yielding the free energy of transfer. In COSMO-RS, the solvation free energy is computed from quantum chemical surface charge densities, allowing for the estimation of partition coefficients through thermodynamic cycles. The key relation is the free energy of transfer from water to octanol, given by \Delta G_{\text{transfer}} = \Delta G_{\text{octanol}} - \Delta G_{\text{water}}, where log P = -\Delta G_{\text{transfer}} / (2.303 RT), with typical root-mean-square deviations around 0.3 log units for neutral compounds. This approach excels for ionic and polar species, where continuum solvation models capture electrostatic and dispersion interactions effectively. For instance, COSMO-RS has been applied to predict log P for electrolytes, accounting for ion-specific effects in mixed solvents. Molecular dynamics (MD) simulations employ free energy perturbation (FEP) to compute partitioning in explicit solvent environments, offering atomistic detail on solute-solvent interactions. In FEP-based MD, alchemical transformations gradually mutate the solute between water and octanol phases, yielding solvation free energies via thermodynamic integration or perturbation theory. These simulations use force fields like OPLS-AA or CHARMM to model explicit octanol (often water-saturated) and water boxes, achieving accuracies of 0.5-1.0 log units for small organics in blind challenges. Such methods are computationally intensive but valuable for validating ML models or studying conformational effects in flexible molecules. Machine learning techniques have advanced log P prediction through deep neural networks (DNNs) and ensemble methods like random forests, trained on large datasets of experimental values. DNNs, utilizing graph representations of molecular structures, capture nonlinear relationships in solvation, as demonstrated in a 2021 study where models trained on over 10,000 compounds achieved mean absolute errors below 0.4 log units on held-out data.[38] Random forests, employing descriptors derived from SMILES strings (e.g., molecular fingerprints or graph features), provide interpretable predictions with similar accuracy, often outperforming traditional QSAR for diverse datasets by handling high-dimensional inputs robustly. Recent developments include consolidated datasets that integrate multiple experimental sources and hybrid quantum mechanical/machine learning approaches that combine QM-derived features with neural networks to improve predictions while retaining physical interpretability. As of 2024, commercial tools like ACD/LogP have expanded their training sets, enhancing overall accuracy for log P calculations.[34][39]Applications
In Drug Discovery and Pharmacology
The octanol-water partition coefficient, denoted as log P, is integral to drug discovery for predicting absorption, distribution, metabolism, and excretion (ADME) profiles, particularly in optimizing lead compounds for oral bioavailability. Lipinski's Rule of Five, formulated to guide the selection of drug-like molecules, specifies that compounds with a log P exceeding 5 are prone to poor absorption due to excessive lipophilicity, while values below 1 may compromise membrane permeability; an optimal range of 1 to 5 balances solubility and passive diffusion. This guideline correlates with permeability assessments in parallel artificial membrane permeability assay (PAMPA) models, where log P values in this range predict effective transcellular transport, with permeability increasing linearly up to log P ≈ 3 before plateauing due to solubility limitations.[40][41] In pharmacology targeting the central nervous system (CNS), log P ≈ 2 facilitates optimal blood-brain barrier (BBB) penetration by promoting passive diffusion while limiting non-specific tissue binding, as evidenced by quantitative structure-activity relationship (QSAR) analyses of CNS-penetrant drugs. This value also mitigates efflux by P-glycoprotein (P-gp), an ATP-binding cassette transporter that actively pumps out highly lipophilic substrates (log P > 3), thereby enhancing brain exposure for therapeutic efficacy.[42] Log P informs toxicity prediction models, where elevated values (>4) heighten the risk of human ether-à-go-go-related gene (hERG) potassium channel inhibition, potentially causing QT interval prolongation and arrhythmias, as integrated into physicochemical QSAR frameworks for early risk assessment. Similarly, log P is a key descriptor in QSAR models for metabolic stability, with moderate values (1-4) favoring hepatic clearance via cytochrome P450 enzymes without excessive phase I metabolism liability. In statin development, atorvastatin (log P ≈ 6.4) exemplifies log P considerations, where its high lipophilicity required formulation strategies to improve solubility and oral absorption, reducing off-target effects compared to more hydrophilic analogs like pravastatin.[43][44][45][46]In Environmental and Toxicological Studies
The octanol-water partition coefficient plays a crucial role in environmental studies for assessing the fate and transport of organic chemicals, particularly their potential for bioaccumulation in aquatic ecosystems. The bioconcentration factor (BCF), which measures the accumulation of a substance from water into an organism's tissues, correlates strongly with log P values through models like the Gobas food web bioaccumulation model. For aquatic organisms, empirical relationships indicate that log BCF ≈ 0.8 log P - 0.4 for moderately hydrophobic chemicals, reflecting how lipophilic compounds partition preferentially into lipid-rich tissues, thereby increasing their concentration relative to surrounding water; however, for log P > 6, bioaccumulation may plateau due to solubility limits and reduced uptake.[47] This relationship highlights the risk of trophic magnification in food chains for moderately hydrophobic substances. In soil and sediment environments, log P informs predictions of chemical partitioning between water and solid phases, aiding evaluations of mobility and long-term persistence. The Karickhoff equation relates the organic carbon-water partition coefficient (Koc) to log P as log Koc ≈ log P - 0.21 (or Koc ≈ 0.63 Kow), indicating that higher log P values enhance sorption to organic matter in soils, reducing leaching to groundwater but promoting retention and potential exposure via soil ingestion or erosion.[48] This sorption behavior is essential for modeling contaminant distribution in terrestrial systems and assessing remediation needs. Regulatory frameworks leverage log P thresholds to screen for persistent, bioaccumulative, and toxic (PBT) substances. Under the European REACH regulation (Annex XIII), a log P > 3 serves as a screening criterion for bioaccumulative (B; BCF ≥ 2000) potential, while log P > 4.5 indicates potential for very bioaccumulative (vB; BCF ≥ 5000), triggering further PBT evaluation if persistence and toxicity criteria are also met when experimental BCF data are unavailable.[49] Similarly, U.S. EPA guidelines identify chemicals with log P > 3 as having bioaccumulation potential in PBT assessments, guiding prioritization for risk management and restrictions on releases. Illustrative examples include persistent pesticides and industrial chemicals like DDT and polychlorinated biphenyls (PCBs), which demonstrate elevated environmental risks due to high log P values. DDT has a log P of 6.91, contributing to its strong bioaccumulation (BCF > 10,000 in fish) and decades-long persistence in soils and sediments, leading to widespread ecotoxicological impacts. PCBs, with log P values ranging from 5.7 for tetra-chlorinated congeners to 7.0 for hexa-chlorinated ones, similarly exhibit high persistence and bioaccumulation, magnifying toxicity through aquatic food webs and prompting global regulatory bans under the Stockholm Convention.[50]Example Values and Databases
Selected Examples
The octanol-water partition coefficient, expressed as log P, varies widely across chemical classes, reflecting differences in hydrophobicity and molecular structure. Representative examples illustrate how log P values range from negative for highly polar compounds to positive and high for nonpolar or fluorinated ones, providing insight into their partitioning behavior.| Compound | Chemical Class | log P Value | Source |
|---|---|---|---|
| Ethanol | Alcohol | -0.31 | Hansch et al. (1995) |
| Phenol | Phenol (pollutant) | 1.46 | Hansch et al. (1995) |
| Benzene | Aromatic hydrocarbon | 2.13 | Hansch et al. (1995) |
| Aspirin | Pharmaceutical | 1.19 | Hansch et al. (1995) |
| Ibuprofen | Pharmaceutical | 3.97 | Hansch et al. (1995) |
| Naphthalene | Polycyclic aromatic | 3.30 | Hansch et al. (1995) |
| DDT | Organochlorine pollutant | 6.91 | de Bruijn et al. (1989) |
| Perfluorooctane | Perfluoroalkane | 8.09 | Computed by XLogP3 (PubChem) |