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DNA virus

DNA viruses are a diverse group of viruses that utilize deoxyribonucleic acid (DNA) as their genetic material, in contrast to RNA viruses, and are characterized by their obligate intracellular parasitic nature, requiring host cell machinery for replication.^[1] Their genomes can be double-stranded (dsDNA) or single-stranded (ssDNA), linear or circular, and are typically enclosed within a protein capsid, with some possessing an outer lipid envelope derived from the host cell membrane.^[1] DNA viruses infect a broad range of hosts, including humans, animals, plants, and bacteria, and are responsible for numerous diseases, from acute infections like the common cold to chronic conditions such as herpes and certain cancers.^[2] In the Baltimore classification system, DNA viruses are categorized into Group I (dsDNA viruses, whose mRNA is synthesized by transcription of the double-stranded genome using RNA polymerase, with genome replication via DNA-dependent DNA polymerase) and Group II (ssDNA viruses, which first convert their genome to dsDNA before transcription), providing a framework based on genome type and mRNA synthesis strategy.^[3] This system, developed in 1971, underscores the evolutionary diversity among DNA viruses while highlighting their shared reliance on host nuclear processes for most replication, except for poxviruses which replicate in the cytoplasm using their own enzymes.^[4] Notable families include Adenoviridae (causing respiratory and gastrointestinal illnesses), Herpesviridae (responsible for herpes simplex, varicella-zoster infections like chickenpox and shingles), Papillomaviridae (linked to warts and human papillomavirus-associated cancers such as cervical cancer), Polyomaviridae (associated with rare tumors like Merkel cell carcinoma), Parvoviridae (causing fifth disease and aplastic crises in humans), and Poxviridae (including the eradicated smallpox virus).^[1]^[2] Many DNA viruses establish latent or persistent infections, evading host immunity and potentially reactivating later, as seen in herpesviruses, while others like adenoviruses typically cause self-limiting acute infections.^[1] Their medical significance extends to vaccine development (e.g., against human papillomavirus and varicella-zoster virus) and ongoing research into antiviral therapies targeting viral DNA polymerases.^[2]

Overview

Definition

DNA viruses are viruses whose genomes are composed of deoxyribonucleic acid (DNA), serving as the primary hereditary material that encodes instructions for viral protein synthesis and replication within infected host cells. These viruses are obligate intracellular parasites, requiring the host's cellular machinery to produce new viral particles, with the DNA genome typically enclosed in a protective protein coat known as a capsid.^[1] Unlike RNA viruses, which use ribonucleic acid (RNA) as their genetic material, DNA viruses employ DNA, resulting in generally lower mutation rates and distinct evolutionary trajectories influenced by the stability of DNA polymerases compared to error-prone RNA-dependent polymerases. This genomic distinction fundamentally shapes their life cycles, as DNA viruses often integrate or replicate their DNA using host nuclear processes, whereas RNA viruses typically operate in the cytoplasm. In the Baltimore classification system, DNA viruses are categorized into Group I (double-stranded DNA viruses) and Group II (single-stranded DNA viruses).^[1] DNA viruses demonstrate remarkable prevalence, infecting a diverse array of hosts spanning bacteria, archaea, protists, plants, fungi, invertebrates, and vertebrates including humans, and they are ubiquitous in global ecosystems, particularly oceans where they constitute a significant portion of the viral abundance and influence microbial population dynamics.^[1] The identification of viruses began in the late 19th and early 20th centuries, with the tobacco mosaic virus (TMV) isolated in 1892 and initially presumed to carry DNA as its genetic material akin to cellular life forms, only to be reclassified as an RNA virus following experiments in 1957 that demonstrated RNA's infectious capability. Confirmation that DNA serves as the genetic material in certain viruses came from the landmark Hershey-Chase experiment in 1952, which used radiolabeled bacteriophage T2 to show that only its DNA enters Escherichia coli cells to orchestrate viral replication, solidifying DNA's role in viral heredity.^[5]^[6]

Key characteristics

DNA viruses are characterized by genomes composed of deoxyribonucleic acid (DNA), which typically range in size from 5 to 250 kilobases (kb), allowing for more genetic information than the smaller genomes of most RNA viruses, owing to the greater chemical stability of DNA that permits larger, more complex structures without frequent degradation.^[7] This size variation accommodates diverse viral strategies, with single-stranded DNA (ssDNA) viruses generally having smaller genomes (around 5 kb) and double-stranded DNA (dsDNA) viruses reaching up to 2,500 kb or more (e.g., in giant viruses), with families like Herpesviridae and Poxviridae having genomes of 150–200 kb.^[8] Structurally, DNA viruses feature protein capsids that protect the genome, which can be either enveloped—surrounded by a lipid bilayer derived from host cell membranes—or non-enveloped, with the capsid directly exposed; common capsid symmetries include icosahedral forms in many families, while others exhibit complex morphologies such as the tailed structures in bacteriophages.^[1] Genomes may be linear or circular, influencing packaging and replication mechanisms, and the overall architecture supports infection across a broad host spectrum, including prokaryotes like bacteria (exemplified by tailed bacteriophages in the order Caudovirales) and eukaryotes such as animals and plants (e.g., herpesviruses in mammals).^[9] Many DNA viruses employ lytic cycles that destroy host cells upon replication or latent or persistent infections where the viral genome may integrate into or persist in the host cell, enabling long-term persistence.^[10] The stability of DNA genomes confers resistance to mutations compared to RNA, resulting from the double-helix structure and associated proofreading during replication, which yields mutation rates orders of magnitude lower (typically 10^{-6} to 10^{-8} per nucleotide per replication cycle) than those of RNA viruses (10^{-4} to 10^{-6}), thereby promoting slower evolutionary rates and greater genetic conservation over time.^[11] For transcription, most DNA viruses, particularly those infecting eukaryotes, rely on the host's RNA polymerase II to synthesize viral messenger RNA (mRNA) from their DNA templates, contrasting with RNA viruses that often encode their own polymerases; this dependence integrates viral gene expression into the host's transcriptional machinery, typically occurring in the nucleus.^[12]

Classification

Baltimore classification

The Baltimore classification system, proposed by virologist David Baltimore in 1971, organizes viruses into seven groups based on the type of nucleic acid in their genome and the mechanism by which they synthesize messenger RNA (mRNA) from that genome. This framework highlights the central role of mRNA in viral replication and gene expression, providing a functional taxonomy that transcends host specificity or morphological traits. DNA viruses are assigned to two of these groups: Group I, comprising double-stranded DNA (dsDNA) viruses, and Group II, consisting of single-stranded DNA (ssDNA) viruses.^[13]^[4] Group I viruses possess dsDNA genomes that function directly as positive-sense templates for transcription into mRNA, utilizing host or viral polymerases. Most replicate within the host cell nucleus, leveraging cellular machinery for DNA replication and transcription, although exceptions like poxviruses carry out these processes in the cytoplasm using their own enzymes. Representative families include Herpesviridae, which cause infections such as herpes simplex, and Adenoviridae, associated with respiratory illnesses. This group encompasses a wide range of viruses infecting animals, plants, and bacteria, unified by their reliance on dsDNA as the genetic material.^[4]^[14] Group II viruses contain ssDNA genomes, typically positive-sense, which are first converted into a dsDNA intermediate upon entry into the host cell; this replicative form then serves as the template for transcription and further genome production. Replication generally occurs in the nucleus, dependent on host DNA polymerases. Key examples include Parvoviridae, small viruses causing diseases like parvovirus B19 in humans, and Geminiviridae, plant pathogens transmitted by insects that lead to crop losses. These viruses are smaller and more limited in host range compared to Group I but share the core strategy of using a dsDNA intermediate for gene expression.^[4] One key advantage of the Baltimore system is its emphasis on replication strategies and mRNA synthesis pathways, offering a simple, mechanistic view of viral diversity that remains relevant for understanding infection processes, independent of evolutionary phylogeny. It contrasts with the International Committee on Taxonomy of Viruses (ICTV) approach, which employs realm-based classification like Duplodnaviria for dsDNA viruses and Monodnaviria for ssDNA viruses to reflect phylogenetic relationships. However, a limitation is that it predates modern genomic insights, such as the polyphyletic origins of ssDNA viruses, which derive from diverse plasmid-like ancestors rather than a single lineage, complicating strict grouping.^[4]^[15]^[16]

ICTV classification

The International Committee on Taxonomy of Viruses (ICTV) utilizes a hierarchical taxonomic system for viruses, with realm established as the highest rank in 2018 to reflect evolutionary relationships based on shared protein folds and morphogenetic modules. DNA viruses exhibit polyphyly, spanning three distinct realms—Duplodnaviria, Monodnaviria, and Varidnaviria—due to their divergent capsid architectures and replication strategies, rather than a monophyletic grouping by genome type alone. This structure contrasts with functional systems like the Baltimore classification (Groups I for dsDNA and II for ssDNA viruses).^[17]^[18]^[19] The realm Duplodnaviria, established in 2020, comprises viruses with linear double-stranded DNA (dsDNA) genomes and major capsid proteins (MCPs) featuring a double jelly-roll fold, a hallmark morphogenetic module conserved across archaeal, bacterial, and eukaryotic hosts. It includes the kingdom Heunggongvirae, which encompasses both prokaryotic viruses (phylum Uroviricota, class Caudoviricetes, including tailed bacteriophages) and eukaryotic viruses (phylum Peploviricota, class Herviviricetes, such as Herpesviridae causing infections in vertebrates and invertebrates).^[20]^[21]^[22] The realm Monodnaviria, introduced in 2019, primarily includes single-stranded DNA (ssDNA) viruses that utilize a rolling-circle replication mechanism, along with some dsDNA viruses sharing this module. It comprises four kingdoms: Loebvirae, Sangervirae, and Trapavirae (primarily prokaryotic ssDNA viruses); and Shotokuvirae (eukaryotic ssDNA and related circular dsDNA viruses). Under Shotokuvirae, phylum Cressdnaviricota includes circular ssDNA viruses such as Geminiviridae (plant pathogens) and Circoviridae (animal pathogens like circoviruses); phylum Cossaviricota includes circular dsDNA viruses like Papillomaviridae (causing warts and cancers) and Polyomaviridae (associated with tumors). Under Loebvirae, phylum Hofneiviricota covers linear ssDNA viruses, such as Parvoviridae (e.g., parvoviruses causing disease in mammals). This realm underscores the evolutionary linkage among small, non-enveloped DNA viruses infecting plants, animals, and prokaryotes.^[23]^[24]^[25] The realm Varidnaviria, created in 2020, groups dsDNA viruses with MCPs containing a single vertical jelly-roll fold, emphasizing vertical transmission in capsid assembly. Its kingdoms include Bamfordvirae, with phylum Nucleocytoviricota for nucleocytoplasmic large DNA viruses (NCLDVs), such as Poxviridae (e.g., vaccinia virus), Mimiviridae (giant viruses infecting amoebae), Iridoviridae, and Phycodnaviridae (algal viruses); and phylum Preplasmiviricota (class Polintoviricetes) for some bacteriophages and viruses like Adenoviridae (causing respiratory illnesses) and families Tectiviridae and Corticoviridae. Additional kingdoms, such as Abadenavirae, cover other prokaryotic dsDNA viruses. This realm captures the structural unity among large, complex dsDNA viruses across eukaryotic and prokaryotic hosts.^[26]^[27]^[28]^[29] As of the 2025 ICTV taxonomy release (version 2, ratified February 2025), updates have integrated metagenomic discoveries from marine viromes and other environments, refining realm boundaries by adding new families and genera—such as expansions in Mimiviridae for giant viruses and novel NCLDV lineages—while maintaining the polyphyletic framework for DNA viruses based on enhanced phylogenetic analyses.^[15]^[30]^[31]

Genome and structure

Double-stranded DNA viruses

Double-stranded DNA (dsDNA) viruses, classified under Baltimore group I, possess genomes consisting of two complementary DNA strands, enabling stable storage of genetic information and facilitating replication through host or viral polymerases. These genomes are typically linear, though some families feature circular forms, and range in size from approximately 5 kb to over 2 Mb, with most falling between 10 and 300 kb to support diverse coding capacities. Many linear dsDNA genomes include inverted terminal repeats (ITRs) at their ends, which serve as origins for replication initiation and protein priming, as seen in adenoviruses where ITRs flank the 26–45 kb genome. This structural organization allows for efficient packaging and uncoating during infection. Adenoviruses exemplify non-enveloped dsDNA viruses with linear genomes packaged in icosahedral capsids, measuring about 90 nm in diameter, which protect the DNA during extracellular transmission. In contrast, herpesviruses feature linear dsDNA genomes of 125–240 kb, enclosed in enveloped icosahedral capsids approximately 125 nm across, with an additional tegument layer that aids in early gene expression and latency establishment. Poxviruses represent a distinct group with large linear dsDNA genomes of 130–300 kb, assembled into complex, brick-shaped virions up to 360 × 270 × 250 nm, featuring multiple protein layers rather than a simple icosahedron. These variations highlight the architectural diversity among dsDNA viruses, adapting to different replication environments. The coding capacity of dsDNA viruses scales with genome size, typically encoding 50–300 proteins, including essential enzymes for DNA metabolism; for instance, herpesviruses encode a dedicated B-family DNA polymerase for replication. Packaging occurs via portal vertices in icosahedral capsids or through specialized motors in complex structures, ensuring dense coiling of the genome within the virion. Most dsDNA viruses, such as adenoviruses and herpesviruses, replicate in the host cell nucleus, briefly referencing this site for genome synthesis. dsDNA viruses maintain genomic stability through proofreading mechanisms in their polymerases, achieving mutation rates of 10^{-8} to 10^{-6} substitutions per nucleotide per replication cycle, far lower than RNA viruses due to 3'–5' exonuclease activity in host or viral enzymes like the herpesvirus polymerase. This fidelity, supported by either cellular DNA repair pathways or virus-encoded factors, minimizes errors across large genomes and supports long-term persistence in hosts.

Single-stranded DNA viruses

Single-stranded DNA (ssDNA) viruses possess genomes that are notably compact, typically ranging from 1 to 8 kilobases (kb) in length, and exist as either linear or circular molecules. These genomes are single-stranded and can be of positive-sense or negative-sense polarity, with many requiring host-mediated conversion to a double-stranded DNA replicative form (RF) to initiate transcription and replication. Unlike the larger genomes of double-stranded DNA viruses, which often exceed 100 kb, ssDNA viral genomes prioritize efficiency due to their small size.^[32]^[33] Representative examples include parvoviruses, which feature linear ssDNA genomes of approximately 5 kb packaged in non-enveloped icosahedral capsids, and circoviruses, which have circular ssDNA genomes around 2 kb also enclosed in small icosahedral structures. The replication process in these viruses generates double-stranded intermediates, such as the covalently closed circular RF in circoviruses or hairpin-containing RF in parvoviruses, which serve as templates for both transcription and further genome amplification. This intermediate stage is essential, as the initial ssDNA genome alone cannot directly support protein synthesis.^[34]^[35]^[36] Structurally, ssDNA viruses package their genomes tightly coiled within small icosahedral capsids, often 17-26 nm in diameter, to accommodate the nucleic acid's flexibility and density. This packaging is facilitated by numerous capsid-genome interactions, enabling cooperative assembly similar to that in single-stranded RNA viruses, though the ssDNA must be condensed without the rigidity of double-stranded forms. High gene density is a hallmark, with overlapping reading frames allowing a limited genome to encode essential proteins like the capsid protein and replication-associated protein (Rep), maximizing coding capacity in these minimalistic blueprints.^[37]^[38] Mutability in ssDNA viruses is elevated during the exposed ssDNA phase, where deamination and other chemical instabilities can introduce errors more readily than in double-stranded forms, contributing to evolutionary adaptability. However, their overall mutation rates, ranging from 10^{-8} to 10^{-6} substitutions per nucleotide per cell cycle, remain lower than those of RNA viruses (10^{-6} to 10^{-4}), reflecting proofreading by host enzymes during RF synthesis. These viruses exhibit strong dependence on host DNA polymerases for second-strand synthesis and RF maintenance, often persisting as extrachromosomal episomes in the nucleus without integrating into the host genome. Such interactions highlight their reliance on cellular machinery for propagation, particularly in non-dividing cells where polymerase availability is limited.^[39]^[40]

Replication

General process

The replication cycle of DNA viruses follows a series of conserved steps that enable the production of progeny virions, typically spanning 4 to 48 hours depending on the virus and host cell conditions. This process begins with attachment and culminates in release, relying heavily on host cellular machinery while the virus directs key enzymatic activities. Although variations exist based on genome type—such as double-stranded (dsDNA) or single-stranded (ssDNA)—most DNA viruses share these fundamental phases, with replication often occurring in the nucleus except for exceptions like poxviruses.^[41]^[42]^[43] Attachment initiates the cycle, where viral surface glycoproteins or capsid proteins specifically bind to host cell receptors, such as heparan sulfate proteoglycans, integrins, or sialic acid residues, facilitating initial contact and determining host tropism. This step is highly specific and energy-independent, mediated by electrostatic and hydrophobic interactions between the virion and the plasma membrane. For example, herpes simplex virus (HSV) uses glycoprotein C to bind heparan sulfate on target cells. Following attachment, entry occurs through mechanisms like receptor-mediated endocytosis, direct membrane fusion, or, rarely, genome injection, allowing the viral capsid to penetrate the cell. In endocytosis, the virion is engulfed in a vesicle that acidifies, triggering uncoating; fusion involves viral fusion proteins merging the envelope with the host membrane. Uncoating then releases the viral genome, often transporting it to the nucleus via microtubules and nuclear pore complexes for dsDNA viruses.^[41]^[41]^[41] Once inside, gene expression and genome replication proceed in temporal phases. The viral genome, uncoated in the nucleus, is transcribed by host RNA polymerase II into mRNA, starting with immediate-early genes that encode regulatory proteins to hijack host transcription machinery. This is followed by early genes producing enzymes for DNA replication, such as DNA polymerase and thymidine kinase, enabling the synthesis of multiple genome copies using host nucleotides and factors. Late genes are then expressed, coding for structural proteins like capsids and envelope components. For ssDNA viruses, the genome is first converted to dsDNA by host DNA polymerase before replication. Assembly occurs concurrently, with newly synthesized genomes packaged into procapsids in the nucleus or cytoplasm, often requiring viral scaffolding proteins for maturation; enveloped DNA viruses acquire their lipid bilayer during this phase. Finally, release happens via cell lysis, which bursts the host membrane to liberate non-enveloped virions, or budding, where enveloped particles egress by wrapping in host-derived membranes without immediate cell death, ensuring virion infectivity.^[41]^[41]^[41]

Specific replication strategies

DNA viruses exhibit a variety of replication strategies adapted to their genome structures and host cellular machinery, ensuring efficient genome amplification within infected cells. These mechanisms include bidirectional theta replication for many double-stranded DNA (dsDNA) viruses, rolling circle replication prevalent in both single-stranded DNA (ssDNA) and some dsDNA viruses, strand displacement in adenoviruses, replicative transposition in certain tailed bacteriophages, and conversion of ssDNA to dsDNA intermediates. Overall, these processes maintain high replication fidelity, with error rates typically ranging from $10^{-6} to $10^{-8} errors per base, attributed to the proofreading exonuclease activity of DNA polymerases involved. Poxviruses replicate their linear dsDNA genomes in the cytoplasm using virally encoded enzymes, including a multi-subunit DNA polymerase, helicase-primase, and others. Replication initiates via a self-priming mechanism at the hairpin termini, producing long concatemers that are resolved into unit-length genomes by viral recombination and resolution enzymes like a Holliday junction endonuclease. This occurs within cytoplasmic viral factories.^[44]^[14] In dsDNA viruses with circular genomes, such as herpesviruses and papillomaviruses, replication often proceeds bidirectionally from a specific origin of replication in a theta mode, forming a theta-shaped intermediate as the replication forks progress. This origin-initiated process recruits viral and host proteins to unwind the DNA and synthesize leading and lagging strands simultaneously, allowing for rapid duplication of the genome. The velocity of the replication fork, which determines the rate of nucleotide incorporation, is given by the equation v = \frac{dN}{dt}, where v is the fork speed, N is the number of nucleotides added, and t is time; in eukaryotic viruses, this speed typically ranges from 10 to 100 nucleotides per second.^[45]^[46] Rolling circle replication, employed by ssDNA viruses like parvoviruses and some dsDNA viruses such as herpesviruses during later stages, generates long linear concatemers of the genome to facilitate high-yield production. The process begins with a viral endonuclease nicking one strand at the origin of replication (ori), creating a 3' hydroxyl end that serves as a primer for DNA polymerase. As synthesis proceeds, the non-template strand is displaced, resulting in a single-stranded tail that extends into a concatemer with multiple genome units; this displaced strand is later converted to dsDNA by host or viral polymerases.^[47]^[48] Adenoviruses utilize a specialized strand displacement mechanism for their linear dsDNA genomes, where the viral DNA polymerase extends the new strand without fully unwinding the parental duplex, thereby displacing the non-template strand. Initiation occurs at the genome ends via a protein-primed mechanism involving a pre-terminal protein covalently linked to the 5' end, followed by polymerase progression that releases single-stranded DNA intermediates. These displaced strands are then replicated into duplex forms using host factors, enabling efficient amplification in the nucleus. Single-stranded DNA-binding proteins stabilize the displaced strands during this process.^[49]^[50] Tailed bacteriophages like Mu employ replicative transposition to integrate and replicate their dsDNA genomes within the host chromosome. This involves site-specific recombination where the phage transposase (MuA) recognizes the phage ends and inserts the genome at random or semi-random target sites, simultaneously replicating the inserted copy through a cointegrate intermediate. The process generates direct repeats at the integration junctions and allows multiple rounds of transposition during lytic growth, amplifying the genome without relying on host origins.^[51]^[52] For ssDNA viruses, such as parvoviruses and geminiviruses, the initial replication step involves conversion of the incoming single-stranded genome to a double-stranded replicative form by host DNA polymerase, which synthesizes the complementary strand using the viral ssDNA as a template. This occurs in the nucleus, where the ssDNA is uncoated and serves directly as a primer-template for host polymerase δ or ε, often with assistance from viral proteins like Rep that initiate nicking for subsequent rolling circle amplification. The resulting dsDNA intermediate then supports transcription and further replication cycles.^[48]

Diseases and hosts

Human pathogens

DNA viruses from several families are significant human pathogens, causing a range of acute and chronic diseases, including respiratory infections, skin lesions, neurological disorders, and cancers. These viruses often establish lifelong infections, with latency or persistence in host cells contributing to recurrent symptoms or long-term health risks. Key families include Herpesviridae, Papillomaviridae, Adenoviridae, Polyomaviridae, Parvoviridae, and Poxviridae, each associated with distinct clinical manifestations primarily in humans. The Herpesviridae family encompasses eight human-specific herpesviruses, with herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) causing oral and genital sores, respectively, through blistering lesions that recur due to viral latency in sensory neurons. Varicella-zoster virus (VZV) leads to chickenpox in primary infection and shingles upon reactivation, characterized by painful vesicular rashes along dermatomes. Epstein-Barr virus (EBV) is linked to infectious mononucleosis, presenting with fever, sore throat, and lymphadenopathy, and contributes to malignancies such as Burkitt lymphoma and nasopharyngeal carcinoma via oncogenic transformation in B cells. Latency is a hallmark of these viruses, allowing lifelong persistence and reactivation under stress or immunosuppression.^[53] Papillomaviridae viruses, particularly human papillomavirus (HPV) types 16 and 18, cause benign warts and are responsible for nearly all cervical cancers through integration into host DNA and disruption of cell cycle control. Low-risk types like HPV-6 and -11 lead to genital warts, while high-risk types promote anogenital and oropharyngeal cancers. The Gardasil vaccine, introduced in 2006, targets these major oncogenic types and has significantly reduced cervical cancer incidence in vaccinated populations.^[54] Adenoviridae viruses commonly cause respiratory infections, such as pharyngitis, pneumonia, and bronchitis, as well as conjunctivitis (pink eye), with outbreaks frequent in children and military settings. Over 50 serotypes exist, but types 3, 4, 7, and 14 are most associated with severe illness in vulnerable groups. These infections are typically self-limiting but can lead to complications like otitis media in young children.^[55]^[56] Polyomaviridae includes the JC virus (human polyomavirus 2), which infects 50–80% of individuals asymptomatically early in life but reactivates in immunocompromised hosts to cause progressive multifocal leukoencephalopathy (PML), a demyelinating brain disease with ataxia, cognitive decline, and motor deficits. PML primarily affects those with HIV/AIDS or on immunosuppressive therapy, with no specific antiviral treatment available. Additionally, Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma, a rare but aggressive skin cancer, through viral integration and T-antigen expression promoting oncogenesis.^[57]^[58] Parvoviridae viruses, particularly parvovirus B19, cause erythema infectiosum (fifth disease), characterized by a distinctive "slapped cheek" rash in children, along with mild flu-like symptoms. In adults, it can lead to joint pain and swelling. The virus also triggers transient aplastic crisis in individuals with underlying hemolytic anemias, such as sickle cell disease, by suppressing red blood cell production, and hydrops fetalis in pregnant women if infection occurs in the first or second trimester. Cases of parvovirus B19 increased notably in 2024, particularly in the United States.^[59]^[60] Poxviridae human pathogens include variola virus, which caused smallpox—a disfiguring, often fatal disease eradicated globally in 1980 through vaccination—and molluscum contagiosum virus, responsible for benign, pearly skin papules that spread through contact and resolve spontaneously but can persist in immunocompromised individuals. Smallpox featured high fever, rash progressing to pustules, and a 30% mortality rate, while molluscum contagiosum is more common in children and sexually active adults.^[61]^[62] Epidemiologically, DNA viruses infect billions worldwide, with HSV-1 alone affecting approximately 3.8 billion people under age 50 (64% prevalence, as of 2025), establishing lifelong infections.^[63] Certain DNA viruses, such as HPV and EBV, contribute to about 15% of global cancer cases, underscoring their public health impact through oncogenic mechanisms.^[64]

Pathogens in other organisms

DNA viruses infect a wide array of non-human organisms, playing significant roles in animal health, plant agriculture, microbial ecology, and global biogeochemical cycles. In animals, the African swine fever virus (ASFV), a member of the Asfarviridae family with a double-stranded DNA genome, causes a highly lethal hemorrhagic disease in domestic pigs, characterized by mortality rates approaching 100% and substantial economic impacts on the swine industry.^[65] Similarly, iridoviruses, large double-stranded DNA viruses from the Iridoviridae family, infect fish, amphibians, and reptiles, leading to systemic diseases such as lymphocystis in fish and ranaviral hemorrhagic conditions in amphibians, which can decimate wild and farmed populations.^[66] These animal pathogens highlight the zoonotic potential and parallels to human viral infections through shared viral families like Herpesviridae, though their primary impacts are veterinary.^[67] In plants, DNA viruses from the Caulimoviridae family, which possess double-stranded DNA genomes replicated via reverse transcription, cause notable crop diseases; for instance, cauliflower mosaic virus (CaMV) induces mosaic symptoms and stunting in brassica crops like cauliflower and cabbage, resulting in yield reductions of up to 50% in infected fields, particularly in temperate regions. Complementing these, geminiviruses, single-stranded DNA viruses transmitted by insect vectors such as whiteflies and leafhoppers, affect a broad range of crops including tomatoes, cassava, and cotton, leading to leaf curling, stunted growth, and severe yield losses worldwide.^[68] These plant DNA viruses collectively contribute to annual global agricultural losses estimated at tens of billions of dollars, underscoring their economic significance in food security.^[69] Bacteriophages, or phages, represent another critical category of DNA viruses targeting prokaryotes; T4-like myoviruses, with their double-stranded DNA genomes, infect bacteria such as Escherichia coli through lytic cycles that cause host cell lysis, thereby regulating bacterial populations and facilitating horizontal gene transfer via transduction, which influences microbial evolution and diversity.^[70] Beyond bacteria, giant viruses from the Mimiviridae family, including mimiviruses with large double-stranded DNA genomes, primarily infect amoebae in aquatic environments and play a pivotal ecological role by lysing protist hosts, thereby influencing marine microbial food webs and contributing to carbon cycling through the release of organic matter that supports bacterial remineralization.^[71] Economically, veterinary interventions against animal DNA viruses are vital; for example, vaccines targeting pseudorabies virus (a double-stranded DNA alphaherpesvirus affecting pigs) have effectively controlled outbreaks in swine herds, reducing mortality from respiratory and neurological symptoms through attenuated live or inactivated formulations.^[72] Overall, these non-human DNA virus infections drive ecological dynamics, such as biodiversity regulation in aquatic systems, while imposing substantial costs on agriculture and aquaculture.^[73]

Evolution

Origins

DNA viruses are thought to have multiple independent origins, emerging from cellular genetic elements such as plasmids and transposons during the early evolution of life on Earth, around 3 to 4 billion years ago. This hypothesis posits that DNA viruses arose after RNA-based systems, as part of a broader "ancient virus world" that predated the last universal common ancestor (LUCA) of modern cells, evolving within precellular compartments like hydrothermal vents.^[74] Comparative genomics of viral hallmark genes, including the jelly-roll capsid protein and superfamily 3 helicase—absent in cellular genomes but shared across diverse viruses—supports this precellular derivation, indicating viruses as ancient replicators that later became obligate intracellular parasites.^[74] Key evidence for these ancient origins comes from endogenous viral elements (EVEs), viral sequences integrated into host genomes that serve as genomic fossils. In eukaryotes, EVEs from ssDNA viruses, such as geminivirus-like sequences resembling retrotransposons, have been identified in fungal genomes like that of Tuber melanosporum, suggesting viral contributions to host transposon evolution.^[32] Similarly, dsDNA virus EVEs, including polinton-like viruses (PLVs), are widespread in protist and animal genomes, with purifying selection in vertebrates indicating functional roles in host adaptation.^[75] These integrations, some dating to 40–50 million years ago for circoviruses and parvoviruses in animal hosts, reveal a history of repeated endogenization events that trace viral lineages deep into eukaryotic evolution.^[32] Double-stranded DNA (dsDNA) viruses likely originated from primordial plasmids or escaped fragments of cellular DNA, with bacteriophages representing an early prokaryotic form that predates eukaryotes. Genomic analyses show eukaryotic dsDNA viruses, such as those in the Nucleocytoviricota phylum, evolved through recombination with bacteriophage ancestors during eukaryogenesis, acquiring genes from both bacterial and archaeal sources.^[76] Single-stranded DNA (ssDNA) viruses, unified in the realm Monodnaviria, trace their roots to bacterial and archaeal rolling-circle replicating plasmids, evolving via fusion with capsid genes from positive-sense RNA viruses.^[77] This modular assembly underscores multiple emergence events in prokaryotic environments, long before eukaryotic hosts.^[77] Through co-evolution, DNA viruses have profoundly influenced host immunity, driving the diversification of adaptive immune components. For instance, long-term interactions between herpesviruses and vertebrates have fueled an arms race, promoting the evolution of major histocompatibility complex (MHC) class I alleles like HLA-B to enhance pathogen recognition and immune evasion countermeasures.^[78] Such dynamics, evidenced by phylogenetic congruence between viral and host immune genes, highlight viruses as key architects of host defense systems across billions of years.^[78]

Phylogenetic diversity

DNA viruses exhibit polyphyletic origins, as they do not form a single monophyletic group but are distributed across multiple distinct lineages within the International Committee on Taxonomy of Viruses (ICTV) classification system. Specifically, DNA viruses are partitioned into at least three major realms—Duplodnaviria, Monodnaviria, and Varidnaviria—reflecting independent evolutionary histories based on conserved genomic and structural features rather than a shared common ancestor for all DNA viruses.^[17] This polyphyly is evident in the disparate architectures of their replication and capsid assembly modules, which have evolved convergently in response to similar selective pressures across viral lineages.^[79] Within the realm Duplodnaviria, viruses share a conserved morphogenetic module characterized by a major capsid protein (MCP) with the HK97 fold, alongside genes for a genome-packaging ATPase and terminase, enabling tailed capsid structures observed in bacteriophages, herpesviruses, and related viruses across bacterial, archaeal, and eukaryotic hosts.^[21] This realm encompasses a broad phylogenetic diversity, with capsid gene homologs distributed across kingdoms, underscoring ancient divergences and adaptations to diverse cellular environments. In contrast, the realm Varidnaviria includes viruses with MCPs featuring double β-jelly roll folds, such as adenoviruses, polyomaviruses, and giant viruses like mimiviruses, which can encode over 1,000 genes, far exceeding typical viral genome sizes and incorporating complex metabolic functions.^[80] These phylogenies highlight the realm's expansive diversity, from small icosahedral viruses to massive nucleocytoviruses that rival small eukaryotic genomes in complexity.^[81] Horizontal gene transfer (HGT) plays a pivotal role in shaping the phylogenetic diversity of DNA viruses, facilitating the exchange of genetic material between viruses and their hosts, as well as among viral lineages. For instance, polinton-like viruses (PLVs), which are integrative dsDNA elements akin to selfish genetic mobiles, exhibit evidence of HGT with poxviruses, including shared genes for capsid proteins and polymerases that suggest polintons as evolutionary precursors to certain large DNA viruses. Such transfers are widespread, contributing to mosaic genomes that enhance viral adaptability, such as acquiring host-like metabolic genes to manipulate cellular processes during infection.^[82] Recent metagenomic advances since 2020 have unveiled substantial uncultured diversity in marine DNA viruses, particularly single-stranded DNA (ssDNA) forms, with long-read sequencing revealing novel lineages in oligotrophic ocean environments that dominate microbial lysis and nutrient cycling.^[83] In parallel, studies from 2023 to 2025 on giant viruses within Varidnaviria have identified expanded auxiliary metabolic genes (AMGs) in ocean viromes, including those modulating carbon, sulfur, and phosphorus pathways, which enhance host metabolic reprogramming and reveal previously undetected functional roles in global biogeochemical cycles.^[84] These discoveries, derived from genome-resolved metagenomics, have expanded the known Nucleocytoviricota phylum by recovering hundreds of new genomes with alternative genetic codes and novel gene cassettes. Global estimates suggest the virosphere comprises over 10^8 distinct viral species, a figure derived from metagenomic surveys extrapolating from sampled diversity in oceans, soils, and host-associated microbiomes, though this represents only a fraction of the total virosphere.^[85]

References

[1]
Structure and Classification of Viruses - Medical Microbiology - NCBI
Viruses are small obligate intracellular parasites, which by definition contain either a RNA or DNA genome surrounded by a protective, virus-coded protein coat.
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Viral Diseases
The Family Adenoviridae, members of which contain linear double-stranded DNA as their chromosome, includes the agents of acute respiratory disease (ARD), the ...
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Viral Evolution, Morphology, and Classification – Introductory Biology
Baltimore Classification · Group I viruses contain double-stranded DNA (dsDNA) as their genome. · Group II viruses have single-stranded DNA (ssDNA) as their ...
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The Baltimore Classification of Viruses 50 Years Later
Fifty years ago, David Baltimore published a brief conceptual paper delineating the classification of viruses by the routes of genome expression.
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1952: Genes are Made of DNA
Apr 23, 2013 · Hershey and Chase figured that the virus transferred genetic material into the bacterium to direct the production of more virus. They knew that ...
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Tobacco Mosaic Virus - an overview | ScienceDirect Topics
The genetic material of TMV was shown to be RNA, a property previously thought to be restricted to DNA. The first viral protein for which an amino acid ...Missing: initial | Show results with:initial
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Virus DNA - an overview | ScienceDirect Topics
Viral DNA is defined as the genetic material of DNA viruses, which typically consists of double-stranded DNA (dsDNA) and replicates using a DNA-dependent DNA ...<|control11|><|separator|>
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Viral Genome Size Distribution Does not Correlate with the Antiquity ...
The majority of ssDNA viruses has genome sizes that range from 0.8 to 2 kbp (50 and 75%, respectively) (Figure 2B). Quite remarkably, the analysis of the ...Introduction · Materials and Methods · Results · Discussion
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Replication Compartments of Eukaryotic and Bacterial DNA Viruses
In this review, we discuss how DNA viruses that infect both eukaryotic cells and bacteria assemble replication compartments for synthesis of progeny viral DNA.
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Difference between DNA and RNA Viruses - BYJU'S
DNA viruses are present everywhere, especially in the marine ecosystem. Also, they infect both eukaryotes and prokaryotes. Examples – Poxviruses, Herpesviruses ...
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Mechanisms of viral mutation - PMC - PubMed Central
Jul 8, 2016 · Rates of spontaneous mutation vary amply among viruses. RNA viruses mutate faster than DNA viruses, single-stranded viruses mutate faster than ...
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Replication and Expression Strategies of Viruses - PubMed Central
Regardless of their genetic constitution, viral genomes are replicated, expressed, and assembled in association with living host cells.
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Expression of animal virus genomes - PMC - NIH
Bacteriol Rev . 1971 Sep;35(3):235–241. doi: 10.1128/br.35.3.235-241.1971 ... Baltimore D., Huang A. S., Stampfer M. Ribonucleic acid synthesis of ...
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Poxvirus DNA Replication - PMC - NIH
Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins for DNA replication and gene expression.Missing: Baltimore Group
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Current ICTV Taxonomy Release
This taxonomy browser provides access to the current virus taxonomy. This page will be updated whenever a new taxonomy release has been approved by the ICTV.About Virus Taxonomic... · Visual Taxonomy Browser · Taxon Details · Genome
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Origins and evolution of viruses of eukaryotes: The ultimate modularity
The high level classification of viruses that was introduced by Baltimore ... ssDNA viruses are polyphyletic and their roots are in different groups of bacterial ...Missing: limitations | Show results with:limitations
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The new scope of virus taxonomy: partitioning the virosphere into 15 ...
Apr 27, 2020 · The ICTV has changed its Code to allow a 15-rank classification hierarchy that closely aligns with the Linnaean taxonomic system.
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Code | ICTV
The virus classification system shall employ the hierarchical ranks of realm, subrealm, kingdom, subkingdom, phylum, subphylum, class, subclass, order ...Missing: polyphyly | Show results with:polyphyly
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The Baltimore Classification of Viruses 50 Years Later: How Does It ...
Jul 14, 2021 · We discuss an extension of the Baltimore scheme and why many logically admissible expression-replication schemes do not appear to be realized in ...
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Realm: Duplodnaviria - ICTV
Duplodnaviria: a virus is a member of this realm if it has a dsDNA genome encoding a major capsid protein containing the HK97 fold. Viruses of this realm also ...Missing: Monodnaviria | Show results with:Monodnaviria
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ICTV Virus Taxonomy Profile: Duplodnaviria 2025 - PubMed - NIH
The realm Duplodnaviria includes viruses of archaea, bacteria and eukaryotes, with linear dsDNA genomes. Duplodnavirians share a distinct morphogenetic module ...Missing: Monodnaviria | Show results with:Monodnaviria
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ICTV Virus Taxonomy Profile: Duplodnaviria 2025 - PMC
The realm Duplodnaviria includes viruses of archaea, bacteria and eukaryotes, with linear dsDNA genomes. Duplodnavirians share a distinct morphogenetic module ...Missing: classification Monodnaviria<|control11|><|separator|>
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[DOC] 2019.005G.A.v1.Monodnaviria.docx - ICTV
Here we propose a megataxonomic framework for single-stranded DNA (ssDNA) viruses by assigning ICTV-ratified taxa (i.e., species, genera, subfamilies, and ...Missing: Profile | Show results with:Profile
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ICTV Virus Taxonomy Profile: Redondoviridae - PMC - NIH
Taxonomy. Realm Monodnaviria, kingdom Shotokuvirae, phylum Cressdnaviricota, class Arfiviricetes, order Recrevirales; the genus Torbevirus includes two species ...Genome · Table 1 · Fig. 1
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Family: Geminiviridae - ICTV
The geminiviruses are a family of small, non-enveloped viruses with genomes comprising one or two single-stranded, circular DNAs of 2.5–5.2 kb.Missing: Baltimore | Show results with:Baltimore
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Phylogeny of the Varidnaviria Morphogenesis Module - NIH
Jul 16, 2021 · In the new ICTV taxonomy, Varidnaviria are divided into two kingdoms: Bamfordvirae, characterized by a single MCP with a double jelly roll (DJR) ...Missing: Profile | Show results with:Profile
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Family: Poxviridae - ICTV
Poxviridae is a family of enveloped, generally oval or brick-shaped viruses, 220–450 nm long, 140–260 nm wide and 140–260 nm thick.
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Mimiviridae | ICTV
Mimiviridae is a family with one genus, Mimivirus, with a large, resistant particle and a unique star-shaped structure. The name means 'mimicking microbe'.Genus Mimivirus · Virion Properties · Genome Organization And...Missing: virome | Show results with:virome
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Summary of taxonomy changes ratified by the International ... - NIH
Jul 25, 2025 · In March 2025, the vote outcome of the 11 proposals within the mandate of the Animal DNA Viruses and Retroviruses Subcommittee was made public.Missing: Mimiviridae | Show results with:Mimiviridae
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Taxonomic update for giant viruses in the order Imitervirales (phylum ...
Oct 31, 2023 · Here, we describe taxonomic updates for giant viruses in the order Imitervirales that have recently been adopted by the ICTV.Missing: virome | Show results with:virome
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ssDNA viruses: key players in global virome - PMC - PubMed Central
Apr 19, 2019 · The ssDNA viruses consist of a very minimal genetic blue print of a structural coat protein (CP) gene and replication-associated protein (Rep).Introduction · Taxonomy · Unifying Features
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Recombination in Eukaryotic Single Stranded DNA Viruses - PMC
Their genomes can be linear or circular, multi- or single component and are all smaller than 9 Kb in length (Figure 1). There are presently only seven ...6. Recombination Between... · 8.3. Ssdna Secondary... · References And Notes
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The Structures and Functions of Parvovirus Capsids and Missing ...
The viral capsid is around 26 nm in diameter and contains a linear single-stranded DNA (ssDNA) genome of about 5,000 bases. For most parvoviruses, the genome is ...
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Genomic composition and pathomechanisms of porcine circoviruses
Dec 11, 2024 · It comprises single-stranded circular DNA with no envelope, icosahedral symmetry [17], and an average diameter of 17 nm [18]. It is one of the ...
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The Genome of Human Parvovirus B19 Can Replicate in ... - NIH
B19V DNA 4244 is the duplex RF of the B19V genome, which has the capability to replicate and produce progeny virus in B19V-permissive cells (54). The bubbles ...
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Structural Capsidomics of Single-Stranded DNA Viruses - PMC
Feb 27, 2025 · Single-stranded DNA (ssDNA) viruses are a diverse set of viruses belonging to group II of the Baltimore classification [1]. They are among the ...
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Nucleic Acid Packaging in Viruses - PMC - PubMed Central
Assembly of virions with ssDNA and ssRNA genomes usually occurs through a cooperative condensation of the protein and genome, while dsDNA viruses usually pump ...
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Viral Mutation Rates - PMC - NIH
We find that the lowest μs/n/c estimate among RNA viruses is 1.6 × 10−6 and the highest among DNA viruses is 1.1 × 10−6. Hence, although our data show no ...
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Complexities of Viral Mutation Rates - PMC - NIH
May 2, 2018 · On a per-site level, DNA viruses typically have mutation rates on the order of 10−8 to 10−6 substitutions per nucleotide site per cell infection ...
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Virus Replication - PMC - PubMed Central
There are seven classes of viruses in the Baltimore classification system, which is based upon the type of nucleic acid and replication strategy of viruses: ...
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Adenovirus DNA Replication - PMC - NIH
Within 40 h, an infected cell produces approximately one million copies of viral DNA.
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The Replication Cycle of Varicella-Zoster Virus - NIH
Our results define the productive cycle of VZV infection in a single cell as occurring in 9 to 12 h.
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Fidelity of DNA replication—a matter of proofreading - PMC
The proofreading on average improves replication fidelity by about 10–1000-fold. The errors that escape proofreading are repaired later by the mismatch repair ...
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dsDNA bidirectional replication - ViralZone - Expasy
This kind of replication is used by all cellular organisms and some DNA viruses. It is the most classical way of replicating genomic nucleic acid.
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Speed of replication fork - Various - BNID 111770 - BioNumbers
The human genome is 700-fold larger than the E. coli genome, but the replication fork speed is 20-fold slower (2–3 kb/min). Thus, it would take at least 20 ...
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dsDNA rolling circle replication - ViralZone - Expasy
This kind of replication is used by many dsDNA viruses. 1. DNA replication begins at specific locations in the genome, called origins.
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Replication mechanisms of circular ssDNA plant viruses and their ...
Sep 11, 2023 · The only ssDNA viruses infecting plants, is believed to be processed by rolling-circle replication (RCR) and recombination-dependent replication (RDR) ...
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DNA strand displacement replication - ViralZone - Expasy
During strand displacement replication, only one strand is replicated at a time. This synthesis releases a single-stranded DNA, which in turn is copied into a ...
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Viral and cellular interactions during adenovirus DNA replication
Nov 25, 2019 · Viral genomes present within capsids also have two copies of a mature form of the viral terminal protein (TP) covalently attached to the 5′ ends ...Viral And Cellular... · The Adenovirus Genome · Viral Replication...<|separator|>
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Bacteriophage Mu: a transposing phage that integrates like ...
Bacteriophage Mu uses a specialized type of genetic recombination called transposition to both integrate its DNA into that of the host and to amplify its DNA ...
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The Mu story: how a maverick phage moved the field forward - PMC
Dec 5, 2012 · This article traces the pioneering contributions of phage Mu to our current knowledge of how movable elements move/transpose.
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Herpesviruses - Medical Microbiology - NCBI Bookshelf - NIH
Of the more than 100 known herpesviruses, 8 routinely infect only humans: herpes simplex virus types 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein- ...
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About HPV - CDC
Jul 3, 2024 · HPV, or human papillomavirus, is a common virus that can cause cancers later in life. You can protect your child from these cancers with HPV ...
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About Adenovirus - CDC
Nov 1, 2024 · Adenoviruses are common and typically cause mild cold or flu-like symptoms. · Adenoviruses can cause illness in people of all ages any time of ...Symptoms · How It Spreads · Prevention
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Clinical Overview of Adenovirus - CDC
Jun 4, 2024 · Adenoviruses most commonly cause respiratory illness. The illnesses can range from the common cold to pneumonia, croup, and bronchitis.
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Progressive Multifocal Leukoencephalopathy/JC Virus: Adult and ...
Oct 19, 2022 · PML is an opportunistic infection of the central nervous system (CNS), caused by the human polyoma virus JC virus (JCV) and characterized by focal ...
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Human polyomavirus JC virus and its associated disorders - PubMed
JC virus (JCV) is a polyomavirus infecting greater than 80% of the human population early in life. Replication of this virus in oligodendrocytes and ...
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About Smallpox - CDC
Oct 22, 2024 · Smallpox was an infectious disease caused by the variola virus. Smallpox has been eradicated, with no cases occurring since 1977.How Smallpox Spreads · Smallpox Vaccine · Smallpox Timeline · View All SmallpoxMissing: molluscum | Show results with:molluscum
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About Molluscum Contagiosum - CDC
Molluscum contagiosum is an infection caused by a poxvirus that causes lesions (growths) that can appear on the body, either alone or in groups.More Information · Overview · Signs And SymptomsMissing: human smallpox
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Viruses and Human Cancer - PMC - PubMed Central - NIH
An estimated 15 percent of all human cancers worldwide may be attributed to viruses [1], representing a significant portion of the global cancer burden.
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African swine fever virus: A re-emerging threat to the swine industry ...
Sep 16, 2022 · African swine fever (ASF) is a devastating disease for the swine industry, characterized by hemorrhagic fever with up to 100% mortality rate.
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https://www.cdc.gov/molluscum-contagiosum/about/index.html
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Engineering iridoviruses: development of reverse genetics and virus ...
Apr 17, 2025 · Iridoviruses are a family of large DNA viruses that infect insects and poikilotherm vertebrates, including amphibians, reptiles, and fish.
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A geminivirus attenuation vector for crop protection using episomal ...
Jul 11, 2025 · These single-stranded DNA viruses are insect transmitted in nature and are responsible for billions of dollars in damage to crops such as ...
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Plant Viruses of Agricultural Importance: Current and Future ...
Feb 27, 2023 · These virus diseases account for yield losses of $30 billion dollars annually to agricultural crops worldwide, threatening the productivity and ...Abstract · Virus Diseases with a... · Disease Management Methods
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Genomes of the T4-related bacteriophages as windows on microbial ...
Oct 28, 2010 · The T4-related bacteriophages are a group of bacterial viruses that share morphological similarities and genetic homologies with the well-studied Escherichia ...Missing: myoviruses lysis<|separator|>
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A distinct lineage of giant viruses brings a rhodopsin photosystem to ...
Sep 23, 2019 · Viruses are increasingly recognized as key participants in the marine carbon cycle, short circuiting the classical flow of carbon through food ...
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Vaccines against pseudorabies virus (PrV) - PubMed
AD in pigs is controlled by the use of vaccination with inactivated and attenuated live vaccines. Starting with classically attenuated live vaccines derived ...
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Recent insights into aquatic viruses: Emerging and reemerging ...
Giant viruses of amoebae, including mimiviruses, marseilleviruses ... When viruses attack algal blooms, the carbon pumps are activated and carbon cycles ...
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The ancient Virus World and evolution of cells | Biology Direct
Sep 19, 2006 · The origin of ancient virus-like agents, the ancestors of the major classes of modern viruses, would follow the stages of evolution of genetic ...Polyphyly Versus Monophyly... · Viral Hallmark Genes... · The Ancient Virus World And...<|control11|><|separator|>
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Endogenous DNA viruses take center stage in eukaryotic genome ...
May 15, 2023 · Endogenous viral elements (EVEs) are common components of eukaryotic genomes that play key roles in transcriptional regulation, antiviral defense, and genetic ...
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Evolution of double-stranded DNA viruses of eukaryotes
The virus world displays an enormous diversity of genome structures and sizes (viral genomes consist of single-stranded (ss) or double-stranded (ds) RNA or DNA ...Diversity Of Dsdna Viruses... · Figure 2 · Table 2
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Multiple origins of prokaryotic and eukaryotic single-stranded DNA ...
Jul 31, 2019 · The CRESS-DNA viruses emerged via recombination between such plasmids and cDNA copies of capsid genes of eukaryotic positive-sense RNA viruses.
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A Coevolutionary Arms Race between Hosts and Viruses Drives ...
Viral species A and B consistently evolve MHC-I like molecules in all 15 simulations, indicating that MHC-I mimics play a major role in their evasion of the NK ...
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A critical analysis of the current state of virus taxonomy - Frontiers
Comparing the Baltimore classification of viruses and the ... These highly ranked polyphyletic entities are not explained by the methodological limitation ...
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Phylogeny of the Varidnaviria Morphogenesis Module - Frontiers
Jul 15, 2021 · Here, we analyzed the evolutionary history of Varidnaviria based on single and concatenated phylogenies of their MCPs and pATPases.<|separator|>
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Natural history of eukaryotic DNA viruses with double jelly-roll major ...
We used protein structure modeling and analysis to show that protein-primed DNA polymerases (pPolBs) of polintons, virophages, and cytoplasmic linear plasmids ...Missing: evidence | Show results with:evidence
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Widespread Horizontal Gene Transfer Among Animal Viruses - PMC
Mar 26, 2024 · The widespread horizontal transfer of genes among virus groups differs from the typical pattern observed for eukaryotes, which evolve primarily ...
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Long-read powered viral metagenomics in the oligotrophic ... - NIH
May 14, 2024 · Ocean viruses directly influence availability of carbon via host lysis; structure microbial communities through negative density dependent ...
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Unraveling the habitat preferences, ecological drivers, potential ...
Jul 22, 2024 · Functional analysis of 44 newly recovered giant virus genomes revealed novel auxiliary metabolic genes related to carbon, sulfur, and phosphorus ...
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Estimated size of the total genome and protein space of viruses
Feb 25, 2025 · The estimate suggests that there are at least 8.23e+08 viral operational taxonomic units and 1.62e+09 viral protein clusters on Earth.
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The global virome: How much diversity and how many independent ...
Sep 12, 2022 · There are four expansive realms of viruses: Riboviria, Monodnaviria, Duplodnaviria and Varidnaviria, each including a huge diversity of viruses ...Missing: polyphyly | Show results with:polyphyly<|separator|>