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E4

1.e4, commonly notated as the King's Pawn Opening in chess, constitutes White's most frequent initial move, advancing the pawn guarding the king two squares toward the opponent's side to seize control of the central d5 and f5 squares while unblocking lines for the king's bishop and queen. This strategic gambit, rooted in the principles of rapid piece development and territorial dominance established since the codification of modern chess rules in the late , underpins a vast array of subsequent variations, including open games against Black's mirroring 1...e5—such as the and —and semi-open defenses like the Sicilian (1...c5) or (1...e6). Employed extensively by elite players including former world champions , who favored aggressive 1.e4 lines for their tactical dynamism, and , who integrated it into his repertoire for its flexibility in both positional and sharp middlegames, the opening exemplifies causal realism in by prioritizing empirical advantages in space and initiative over speculative gambits. While debates persist on its optimality versus 1.d4 in hypermodern contexts—evidenced by database analyses showing comparable win rates at master levels—1.e4 remains a cornerstone for aspiring players due to its alignment with fundamental tenets of center occupation and harmonious development, free from the biases of transient fashion in opening theory.

Entertainment

Broadcasting

E4 launched on 18 January 2001 as a subscription-based digital companion channel to , initially available exclusively on Sky Digital (channel 163) and cable platforms such as NTL and , targeting viewers aged 16-34 with programming broadcast for 12 hours daily. On 10 May 2005, Channel 4 introduced the E4 Music Zone, extending broadcasts to 24 hours a day by filling mornings with music videos, marking the channel's first full-day programming. Channel 4 announced on 16 December 2004 that E4 would transition to status on (DTT), with the launch occurring on 27 May 2005 via the Freeview platform (channel 13 in , , and ; channel 14 in ), coinciding with the start of series 6 to capitalize on event-driven viewership. This move aligned with the ongoing digital switchover process, which began in 2008 and completed nationwide by 2012, enabling wider terrestrial access without subscription fees, though E4 had been available on DTT pay services like since March 2004. E4 is transmitted free-to-air across multiple platforms in the United Kingdom, including DTT via Freeview and Youview (channel 13), satellite via Freesat (channel 122) and Sky (channel 135 for SD/HD, channel 235 for +1 timeshift), and cable via Virgin Media (channel 134). A high-definition simulcast, E4 HD, debuted on 14 December 2009 on Sky+ HD (channel 215), expanding to Virgin Media on 1 April 2010, with content upscaled or natively produced in HD to enhance visual quality for compatible receivers. The channel's streaming service, integrated into Channel 4's on-demand platform, became available alongside linear broadcasts, offering live and catch-up viewing geo-restricted to the and , with 2024 streaming metrics showing significant growth in young adult engagement (24% of total viewing from 16-34-year-olds). E4 maintains a consistent broadcast schedule emphasizing youth-oriented entertainment, with advertising-funded transmission adhering to regulations for public service channels.

Transportation

Roads

The European route E4 is a primary north-south spanning approximately 1,590 kilometers through Sweden, connecting the border with at in the north to in the south. It serves as the country's principal longitudinal highway, facilitating freight and passenger transport along much of Sweden's eastern seaboard parallel to the and the . The route integrates with numbering, often coinciding with Swedish trunk roads like Riksväg 75 in the north and Europaväg 4 signage throughout. From its northern terminus at the E10 junction near , E4 proceeds southward through , passing Luleå and before reaching Boden and continuing via in . Further south, it traverses , , and in central Sweden, entering where it encounters heavy urban congestion around the capital. Beyond Stockholm, the highway links , , , and in Östergötland and Counties, terminating at in near the Öresund Strait. Sections vary from four-lane divided motorways in populated areas to two-lane alignments in rural northern stretches, with speed limits typically ranging from 90 to 120 km/h where conditions permit. E4 functions as a critical artery for Sweden's economy, carrying over 100,000 vehicles daily near and supporting timber, mineral, and industrial logistics from the north. Traffic volumes have strained the route, particularly the 30-kilometer segment through , which lacks capacity for projected growth from population increases and regional commuting. To address this, the (Trafikverket) is constructing the E4 Bypass, a 21-kilometer motorway with 18 kilometers in tunnels, designed to divert through-traffic and reduce inner-city loads by up to 30 percent upon completion expected in the mid-2030s. Other upgrades include the 31-kilometer widening and safety enhancements between and Toftanäs in , completed in phases to improve flow and reduce accident rates on curvier sections. Safety features along E4 incorporate variable speed limits, radar-based vehicle detection for congestion management, and barriers in high-risk zones, responding to challenges like winter icing and heavy truck volumes. The route's development aligns with European Agreement on Main International Traffic Arteries (AGR) standards, emphasizing connectivity to and via ferries from .

Railways

The E4 designation in railways applies to multiple locomotive and trainset classes across different operators and eras. The London, Brighton and South Coast Railway (LB&SCR) E4 class comprised 75 0-6-2T side-tank steam locomotives designed by Robert J. Billinton, constructed between 1897 and 1903 at Brighton Works. Intended primarily for suburban passenger services and mixed traffic, the design evolved from the earlier E3 class with enlarged 5 ft diameter driving wheels for improved speed and a radial trailing axle to enhance stability, coal capacity (3 tons), and water capacity (1,408 gallons). Key specifications included inside cylinders measuring 17.5 in × 26 in, a boiler pressure of 160 psi, and a tractive effort of 18,045 lbf, with an overall weight of 57 tons 10 cwt. Post-1923 railway grouping, the class saw continued use under the Southern Railway and British Railways for freight and passenger workings until the early 1960s, with the last withdrawals occurring around 1962. One locomotive, No. 70 Birch Grove (built 1898), survives in preservation at the Bluebell Railway, where it operated intermittently from 1962 until undergoing major overhaul in 2016 due to firebox issues; it now serves as a static exhibit. The () E4 class, classified as during construction, consisted of 100 steam locomotives designed by and built between 1891 and 1902. Suited for mixed-traffic duties such as agricultural trains, cross-country services, and slower main-line passenger workings, these locomotives featured 5 ft 8 in driving wheels for responsive performance and rearranged steam passages for efficiency, delivering a of 14,700 lbf at 85% pressure with a maximum of 14 tons 3 cwt. Under the () from 1923, they retained the E4 classification but were restricted to Group 2 due to their axle loading, with most scrapped by amid dieselization and trends. None are preserved. Japan's E4 series represented a modern application, as an 8-car (expandable to 16-car) double-decker (EMU) introduced in 1997 by (JR East) for high-capacity Tohoku and Joetsu services. The sets accommodated 1,634 seated passengers in full 16-car formation, prioritizing volume over speed to handle peak demand. Regular operations ceased on October 1, 2021, following replacement by the E5 series, which provided reduced weight, faster acceleration, higher top speeds, and greater scheduling flexibility to meet evolving transport needs without double-deck constraints.

Military

Aircraft

The E-4B aircraft, designated as the Advanced Airborne Command Post and nicknamed "Nightwatch," serves as the National Airborne Operations Center (NAOC) for the , enabling the , Secretary of Defense, and Chairman of the to maintain of U.S. and conventional forces during national emergencies or disruptions to ground-based facilities. A militarized variant of the 747-200, it features hardened construction against (EMP) effects, blasts, and radiation, with an advanced electrical system supporting extensive communications equipment for global connectivity via , high-frequency radio, and secure data links. Development began in the early 1970s as a successor to the EC-135 Airborne Command Post, with the first E-4A prototype flying on June 13, 1973, and achieving initial operational capability in December 1974; all four initial aircraft were delivered between 1974 and 1977. Upgrades to the E-4B standard, completed by 1985, enhanced communications bandwidth, added battle staff facilities, and incorporated improved survivability features, including redundant systems and aerial refueling capability for extended airborne operations. The fleet, consisting of four aircraft operated by the 1st Airborne Command and Control Squadron at , , under , maintains one plane on continuous alert, capable of takeoff within minutes of notification. Key capabilities include directing emergency war orders, coordinating joint forces, and providing a survivable platform for operations, with interior configurations supporting up to 112 personnel, including flight crew, battle staff, maintenance, security, and communications teams across multiple compartments for command, operations, and rest. It lacks offensive armament but relies on speed, altitude, and stealthy mission profiles for protection, with a maximum speed of approximately 600 mph and a range of 7,010 miles unrefueled, extendable indefinitely via KC-135 or KC-46 tankers.
SpecificationDetails
CrewFlight: 26; Mission: up to 86 additional
DimensionsLength: 231 ft 4 in (70.5 m); Wingspan: 195 ft 8 in (59.6 m); Height: 63 ft 5 in (19.3 m)
Engines4 × F103-GE-100 turbofans
Maximum Takeoff Weight800,000 lb (363,000 kg)
Service Ceiling42,000 ft (12,800 m)
The E-4B's role has evolved with modernization programs, including ongoing upgrades to and communications to counter emerging threats, though the Air Force plans to replace it with the (SAOC) by the 2030s, potentially using a derivative for enhanced and capacity.

Personnel ranks

In the United States Armed Forces, the E-4 pay grade designates the fourth level of enlisted personnel, typically achieved after from E-3 following 18–24 months of , depending on the and . This grade marks the transition from junior enlisted roles to positions with increased technical expertise or limited supervisory duties, though responsibilities vary by branch-specific rank titles. Basic monthly pay for an E-4 in 2025 ranges from $3,027.30 for those with less than two years of to $3,824.10 for those with over six years, excluding allowances for , subsistence, and special duties. Branch-specific ranks at E-4 reflect distinct organizational structures and missions. In the Army, E-4 personnel hold either the rank of (SPC), focused on specialized technical skills without command authority, or (CPL), a role involving junior and squad-level supervision. The Marine Corps assigns E-4 to (CPL), emphasizing small-unit as the first NCO grade. The Navy and use (PO3), which involves rate-specific technical duties and petty officer responsibilities within divisions. The and designate (SrA), prioritizing mission execution and eligibility for NCO roles upon further promotion.
BranchE-4 Rank Title(s)Key Responsibilities
Army (SPC), (CPL)Technical specialization (SPC); junior (CPL)
Marine Corps (CPL)Squad-level supervision as entry-level NCO
Navy (PO3)Division technical support and watchstanding
Air Force/Space Force (SrA)Airman development and mission support
Coast Guard (PO3)Sector-specific operations and enforcement
Promotion to E-4 requires meeting time-in-service and time-in-grade minima, passing evaluations, and, in leadership tracks, completing basic for NCO duties; failure to advance can result in lateral moves, such as from to in the to retain technical personnel. E-4s form a significant portion of the enlisted force, often comprising over 20% of personnel in , where they bridge execution and oversight gaps.

Science and technology

Biology and medicine

In , E4 denotes the ε4 of the APOE encoding , a protein involved in and . This confers the strongest known genetic risk for late-onset , with heterozygous carriers facing a 3- to 4-fold elevated lifetime risk relative to ε3/ε3 individuals, and homozygous ε4/ε4 carriers exhibiting up to a 12- to 15-fold increase, often with earlier disease onset around age 68 compared to 84 for non-carriers. The mechanism involves impaired amyloid-β clearance, enhanced , and altered in the , though environmental factors modulate , as not all carriers develop . Beyond Alzheimer's, APOE ε4 associates with heightened risk, elevated LDL , and reduced longevity in population studies. In reproductive endocrinology, E4 designates estetrol, a estrogen synthesized primarily by the fetal liver during the second of via of estriol precursors. Unlike or estrone, estetrol circulates bound mostly to , enabling tissue-specific with minimal impact on clotting factors, breast tissue proliferation, or suppression, which supports its use in drospirenone-estetrol combined oral contraceptives approved since 2021 for reducing rates to under 1% with typical use. Clinical trials demonstrate estetrol's oral bioavailability exceeds 90%, with lower venous thromboembolism risk than ethinylestradiol-based regimens due to neutral effects on hepatic proteins like and coagulation factors. In , E4 refers to a class of ubiquitin-conjugating enzymes that extend multiubiquitin chains on substrates targeted for proteasomal , distinct from E1-E3 enzymes by facilitating polyubiquitination efficiency in processes like control and stress responses. In , E4 proteins from adenovirus early region 4 regulate viral , host progression, and p53-mediated inhibition, while human papillomavirus type 1a E4 forms filaments disrupting networks to aid viral egress. These functions highlight E4's role in pathogen-host interactions, though applications remain largely experimental.

Computing and mathematics

In computing and many programming languages, the "E" notation (also called exponential or ) represents very large or small numbers compactly by indicating the power of 10 following the "E". For instance, 5.67E4 equals 5.67 × 10⁴ = 56,700, and this format is parsed directly in languages like , , and C++ for floating-point literals, avoiding overflow in display or storage. Calculators and output from numerical software, such as or Excel, default to this for precision beyond standard decimal places. In , \mathbb{E}^4 (or E⁴) denotes the four-dimensional , a real \mathbb{R}^4 equipped with the standard inner product inducing the and . This space models rotations via orthogonal transformations preserving distances, representable using pairs of quaternions or elements, as established in Goursat's 1889 classification of rotation groups in four dimensions. Applications include for 4D rotations, for spinors, and for manifolds embedded in E⁴. Specialized uses include the E₄ coefficient in the expansion for elliptic operators on manifolds, quantifying and effects in asymptotic , computed explicitly for nonminimal operators via symbolic methods on standard hardware. In optimization algorithms, ACM classification [E4] categorizes unconstrained multivariate function minimization, as in Algorithm 500 implementing for nonlinear problems without derivatives.

Electronics and engineering

In electronics manufacturing, the marking "e4" on integrated circuits and other surface-mount components denotes a specific lead (terminal) finish type as defined by the / J-STD-609 standard for characterization of tin-lead and lead-free solders and finishes. This code indicates a matte tin () plating over a nickel () underplate, which is lead-free to comply with directives and designed to minimize tin whisker formation that could cause short circuits in assemblies. The e4 finish supports reliable in lead-free processes, with the matte surface providing better wetting than bright tin alternatives, though it requires controlled annealing to avoid compound growth that might degrade solder joint reliability. Manufacturers like incorporate e4 (or similar G4 for enhanced green compliance) in product suffixes to signal this finish, aiding traceability and assembly . E4 Computer Engineering S.p.A., founded in 2002 and headquartered in Italy, is a systems integrator specializing in high-performance computing (HPC), artificial intelligence infrastructure, and edge computing solutions. The company designs and deploys custom clusters using commercial off-the-shelf (COTS) components, including processors from , , and GPUs, for applications in scientific simulation, data analytics, and quantum-HPC hybrids. E4 has supplied petabyte-scale storage and server systems to since 2017, contributing to experiments, and joined International in 2022 to support open-source instruction set architectures for embedded and HPC systems. Its engineering focuses on containerized environments and energy-efficient designs, with recent work integrating quantum accelerators into classical HPC workflows as demonstrated at IEEE Quantum Week 2025. The Empatica E4 is a research-oriented wristband device featuring multimodal sensors for physiological signal acquisition, including photoplethysmography for heart rate, electrodermal activity for arousal detection, and inertial measurement units for motion tracking. Engineered for continuous wear in biomedical studies, it streams data at up to 64 Hz via Bluetooth with on-device processing to reduce latency, achieving medical-grade accuracy validated against gold-standard references in sleep and stress monitoring trials.

Games and sports

Board games

In chess, the notation "e4" denotes the algebraic coordinate of a square on the board or, more commonly in opening theory, the first move 1.e4, advancing White's king's pawn two squares forward to control the center and develop the kingside bishop and queen. This King's Pawn Opening is the most frequent initial move in recorded games, comprising over 40% of master-level encounters and leading to dynamic, often tactical positions that emphasize rapid piece development and central tension. Database analyses, such as those from 365Chess, show 1.e4 in nearly 1.9 million games with White achieving a 52-54% score, slightly behind 1.d4 in win percentage but preferred for its aggressive lines and transposition potential. The move's strategic merits stem from occupying e4 while eyeing d5, freeing lines for the light-squared bishop and queen, and inviting Black's responses that dictate the game's character: symmetrical 1...e5 prompts Open Games like the (1.e4 e5 2.Nf3 Nc6 3.Bb5) or (3.Bc4), fostering balanced but sharp play; asymmetrical counters such as 1...c5 (Sicilian Defense) or 1...e6 (French Defense) yield semi-open structures favoring counterattacks and pawn breaks. Top players like and have employed 1.e4 extensively, valuing its test of Black's defensive resources over closed alternatives. Beginners often learn 1.e4 first due to its illustration of core principles—center control, piece activity, and king safety—resulting in fewer blocked positions than 1.d4 and more immediate tactical opportunities. While some databases indicate a marginal edge for 1.d4 in overall scoring (54.4% vs. 52.8%), 1.e4's prevalence persists at elite levels, with win rates stabilizing around 37-38% for , 30-31% for Black, and 31% draws in large samples. Critics note its vulnerability to prepared defenses like , yet its flexibility sustains its status as a for aggressive White play.

Video games

Every Extend Extra Extreme, commonly abbreviated as E4, is a rhythm-based video game developed by and published by Game Studios for the , released on January 23, 2008, in . The title expands on the mechanics of its predecessor Every Extend Extra, where players trigger chain explosions of enemy formations in time with electronic music tracks to maximize scores and chain multipliers. It includes four gameplay modes: E4: The Game Time Unlimited for endless play, E4: The Game Time Limited for scored timed sessions, S4: Wiz ur Musik which syncs to custom music files, and a multiplayer mode supporting up to four players. The game received praise for its innovative audio-visual synchronization and addictive scoring system, though some critics noted its high difficulty and short play sessions. In the Pokémon series of role-playing video games developed by Game Freak and published by Nintendo, "E4" serves as a common abbreviation for the Elite Four, a quartet of highly skilled Pokémon trainers representing the pinnacle of regional league challenges, encountered after collecting all eight gym badges. First introduced in Pokémon Red and Blue on September 28, 1998, in Japan, the Elite Four members specialize in specific Pokémon types and must be defeated sequentially in a Pokémon League headquarters, followed by a battle against the regional Champion. This structure persists across generations, with variations like rematches or dynamic teams in titles such as Pokémon Scarlet and Violet released on November 18, 2022. The abbreviation "E4" is widely used in player discussions and strategy guides to denote this endgame gauntlet.

Other uses

Geography and codes

The E4 postal district is a postcode area in the covering northeastern parts of , primarily within the London Borough of Waltham Forest, including the localities of , , and Sewardstone. This district forms part of the broader E (Eastern) postcode area managed by , with addresses typically formatted as E4 followed by a space and three characters, such as E4 6AN. It encompasses residential, commercial, and green spaces along the eastern edge of , bordering to the north and east. European route E4 is a designated north-south transnational roadway under the United Nations Economic Commission for Europe (UNECE) agreement on major international traffic arteries, traversing for approximately 1,590 kilometers from the Finnish border at in the north to in the south near the Danish border. The route primarily follows the E4 highway, serving as a key corridor along Sweden's eastern coastal plain and through major cities like , facilitating freight and passenger transport across the country's length. The E4 European long-distance path is an extensive hiking trail network spanning about 12,090 kilometers across multiple countries, from the in through , , , , , , and , extending to via ferry connections. Maintained by the European Ramblers' Association, it includes marked sections for pedestrian use, with notable segments in Greece totaling around 1,800 kilometers from the Bulgarian border to , passing through diverse terrains such as .

Organizations and symbols

E4 is a British free-to-air digital television channel owned and operated by Channel Four Television Corporation, launched on 18 November 2001 as a companion to Channel 4, focusing on entertainment, comedy, and reality programming aimed at viewers aged 15–30. It has broadcast notable series such as Skins (2007–2013), Misfits (2009–2013), and Married at First Sight UK (2018–present), achieving peak viewership of over 3 million for events like Big Brother spin-offs. The E4 Group refers to a of four European associations dedicated to in : the European Association for Quality Assurance in Higher Education (ENQA), the (EUA), the European Association of Institutions in Higher Education (EURASHE), and the European Students' Union (ESU). Formed to promote pan-European standards, the group established the European Quality Assurance Register (EQAR) on 16 March 2008 in , , to register agencies complying with the European Standards and Guidelines for quality assurance. E4 Computer Engineering S.p.A., founded in 2002 in , is a provider of high-performance computing (HPC) systems, storage solutions, and services for scientific research, , and applications, participating in European projects like the European Processor Initiative since 2018. In electronics manufacturing, the "e4" symbol etched on integrated circuit leads or packages indicates a matte tin (Sn) electroplated finish without lead, signifying compliance for soldering processes as specified in IPC/JEDEC J-STD-609A (2009) for component lead finish verification. This contrasts with "e3" for other finishes like palladium or gold, ensuring compatibility with lead-free assembly; the symbol's use became standard post-2006 EU Directive enforcement.

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