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Flocculus

The flocculus is a small, paired lobe of the cerebellum situated at the posterior border of the middle cerebellar peduncle, anterior to the biventer lobule and on the inferior surface of each cerebellar hemisphere.^[1] It forms part of the flocculonodular lobe, the most phylogenetically ancient division of the cerebellum known as the vestibulocerebellum, which also includes the midline nodule of the vermis connected to the flocculi via the inferior medullary velum.^[2] Anatomically, the flocculus receives afferent input from the vestibular system, including primary vestibular afferents from the inner ear and secondary inputs from the vestibular nuclei, integrating sensory information related to head position, balance, and motion.^[3]^[2] Its Purkinje cells project inhibitory signals to the vestibular nuclei and other brainstem structures, modulating motor outputs without direct descending pathways to the spinal cord.^[4] Functionally, the flocculus plays a critical role in ocular motor control, particularly in the vestibulo-ocular reflex (VOR), which stabilizes gaze during head movements by generating compensatory eye rotations.^[3] It is essential for smooth pursuit eye movements, allowing the tracking of moving visual targets, and for gaze holding to prevent eye drift.^[5] Additionally, the flocculus contributes to adaptive motor learning, such as recalibrating the VOR in response to visual-vestibular mismatches, and supports overall balance and postural stability through interactions with the vestibular system.^[4] Lesions in the flocculus can result in impaired eye movement coordination, nystagmus, vertigo, and ataxia, highlighting its importance in sensorimotor integration.^[6]

Anatomy

Location and Gross Morphology

The flocculus is a small, paired lobe that forms a key component of the flocculonodular lobe within the vestibulocerebellum, situated at the lowest level of the cerebellum. It is positioned on the inferior surface of the cerebellum, lateral to the cerebellar tonsils and immediately adjacent to the brainstem, specifically at the posterior border of the middle cerebellar peduncle and anterior to the biventer lobule. This location places the flocculus in close proximity to vestibular inputs, contributing to its role in balance and spatial orientation.^[3]^[7] In terms of gross morphology, the flocculus appears as an oval-shaped structure that protrudes laterally from the cerebellar peduncles. It is connected to the midline nodule via the inferior medullary velum, a thin sheet of white matter that represents the remnant cortical continuity between these structures. The flocculus receives direct attachments through the floccular peduncle, enhancing its integration with broader cerebellar architecture.^[3]^[8]^[9] The flocculus is situated at the posterior border of the middle cerebellar peduncle and superior to the vestibular nuclei in the brainstem, facilitating its interactions with vestibular pathways. Its blood supply is primarily derived from the anterior inferior cerebellar artery (AICA), with occasional contributions from the posterior inferior cerebellar artery (PICA) in anatomical variations.^[3]^[10]^[11]

Microscopic Structure and Circuitry

The flocculus, as part of the cerebellar cortex, exhibits a trilaminar microscopic structure consisting of a molecular layer, a Purkinje cell layer, and a granule cell layer. It is primarily composed of granule cells, which form the densest neuronal population and serve as excitatory interneurons; Purkinje cells, the principal output neurons with extensive fan-like dendritic arbors; and various interneurons including Golgi cells, basket cells, and stellate cells that modulate local circuitry.^[12] The Purkinje cells are organized into five longitudinal zones (zones 1, 2, 3, 4, and C2) in species such as the rabbit, each defined by distinct climbing fiber inputs and projecting to specific targets in the vestibular and fastigial nuclei; for instance, zones 1 and 3 target the superior vestibular nucleus, while zone C2 projects to the medial vestibular nucleus and fastigial nucleus.^[13] Afferent inputs to the flocculus arrive via mossy fibers and climbing fibers. Mossy fibers originate from pontine nuclei, providing visuomotor signals, and from vestibular nuclei, conveying inputs from semicircular canals (for angular acceleration) and otolith organs (for linear acceleration and gravity).^[14] These mossy fibers synapse onto granule cell dendrites in the granule cell layer, exciting them with glutamate. Climbing fibers, arising from subregions of the contralateral inferior olive such as the dorsal cap and ventrolateral outgrowth, directly contact Purkinje cell dendrites, delivering strong, error-signaling excitatory inputs also mediated by glutamate; zonal specificity is evident, with zones 1 and 3 receiving inputs tuned to horizontal optokinetic stimuli, and zones 2 and 4 to vertical stimuli.^[14]^[13] Efferent outputs are exclusively from Purkinje cells, whose axons travel via the ipsilateral floccular peduncle to inhibit target neurons in the vestibular nuclei, such as flocculus target neurons (FTNs) that relay to oculomotor nuclei. These GABAergic projections produce monosynaptic inhibitory postsynaptic potentials (IPSPs) with latencies around 2.3 ms, modulating vestibulo-ocular pathways.^[15] The synaptic organization features parallel fibers—axons of granule cells that ascend through the Purkinje cell layer, bifurcate in the molecular layer, and form en passant excitatory glutamatergic synapses onto Purkinje cell dendritic spines across a broad receptive field.^[12] Climbing fibers wrap around proximal Purkinje dendrites, inducing complex spikes. Bergmann glia, radial processes extending from the Purkinje cell layer into the molecular layer, provide structural support, regulate extracellular potassium, and facilitate synapse formation and maintenance in this circuitry.^[12] Overall, excitatory neurotransmission relies on glutamate from mossy, parallel, and climbing fibers, while Purkinje cells employ GABA for inhibition of downstream targets.^[12]

Function

Vestibulo-Ocular Reflex and Eye Movements

The flocculus plays a central role in the vestibulo-ocular reflex (VOR), a fundamental mechanism that generates compensatory eye rotations in the direction opposite to head velocity to stabilize gaze and prevent retinal slip during head movements. This reflex relies on inputs from the semicircular canals, which detect angular head accelerations, relayed through vestibular mossy fibers to the flocculus. Purkinje cells in the flocculus process these signals and modulate the direct and indirect VOR pathways to ensure precise eye-head coordination.^[16] The flocculus modulates both horizontal and vertical components of eye movements by exerting inhibitory or excitatory influences on the oculomotor and abducens nuclei via intermediate vestibular pathways. For horizontal VOR, floccular outputs adjust the activity of abducens motoneurons to produce conjugate eye rotations, while vertical VOR involves control of oculomotor neurons for torsional and vertical adjustments. This modulation ensures that eye velocity matches head velocity in the appropriate plane, maintaining foveal fixation on targets during transient head perturbations.^[16] In addition to reflexive stabilization, the flocculus contributes to smooth pursuit eye movements by integrating visual signals about target motion with vestibular inputs from head movements. This integration allows the flocculus to adjust eye velocity to track moving objects accurately, compensating for any mismatch between head and target trajectories. Floccular Purkinje cells encode these combined signals, facilitating seamless transitions between pursuit and VOR-driven responses. The flocculus exerts gain control over the VOR, dynamically scaling the reflex amplitude based on head-eye coordination errors to optimize visual stability. By comparing actual and ideal eye movements, floccular circuits prevent excessive or insufficient compensatory rotations that could lead to retinal slip. Experimental lesion studies in primates demonstrate this role: bilateral ablation of the flocculus and paraflocculus results in reduced VOR gain, gaze-evoked nystagmus, and impaired smooth pursuit, leading to oscillopsia—perceived visual instability during head motion. For instance, in rhesus monkeys, such lesions resulted in variable changes to horizontal VOR gain, including decreases of up to approximately 35% in some cases.^[16]

Motor Learning and Adaptation

The flocculus plays a pivotal role in cerebellar motor learning by facilitating long-term depression (LTD) at parallel fiber-Purkinje cell synapses, which refines the accuracy of the vestibulo-ocular reflex (VOR) and smooth pursuit eye movements. This synaptic plasticity mechanism allows Purkinje cells in the flocculus to adjust their inhibitory output to vestibular nuclei, thereby optimizing gaze stabilization through error-driven modifications in simple spike activity. Studies have demonstrated that LTD induction in floccular Purkinje cells correlates with improved motor performance in tasks requiring precise eye-head coordination.^[17] In adaptation to sensory perturbations, the flocculus recalibrates eye movements following exposure to visual distortions, such as those induced by magnifying or reversing goggles, or after vestibular lesions, utilizing climbing fiber inputs as error signals from the inferior olive to guide plasticity. For instance, adaptation to x2 visual magnification increases VOR gain, with floccular Purkinje cells modulating simple spike firing to compensate for retinal slip, while unilateral vestibular deafferentation triggers floccular-dependent recovery of balance and gaze control through enhanced synaptic efficacy. Climbing fibers convey these discrepancy signals, triggering complex spikes that instruct LTD and long-term potentiation (LTP) for bidirectional adjustments. This process ensures that the VOR adapts to maintain visual stability despite altered sensory inputs.^[18]^[19]^[20] The flocculus also contributes to the acquisition of basic motor functions by supporting the learning of coordinated head-eye strategies, particularly during postnatal development and in rehabilitation contexts. In early development, floccular circuits refine VOR amplitude through activity-dependent plasticity, enabling infants to integrate vestibular and visual cues for stable gaze during head movements. In rehabilitation, floccular-mediated learning enhances trainability of eye-head coordination, as seen in protocols that leverage repetitive visuovestibular stimulation to restore function post-injury.^[21]^[22] At the molecular level, floccular synaptic plasticity involves protein kinase C (PKC) and metabotropic glutamate receptor 1 (mGluR1), which are essential for LTD induction and bidirectional VOR adaptation. Activation of mGluR1 in Purkinje cells triggers intracellular cascades leading to AMPA receptor endocytosis, while PKC phosphorylation is required for depotentiation of prior LTP states. Optogenetic studies have shown that targeted induction of LTD at floccular parallel fiber-Purkinje synapses directly enhances VOR adaptation rates, confirming the causal role of this mechanism in motor learning.^[23]^[24]^[25] The flocculus works in coordination with other cerebellar regions, such as the vermis, which handles postural aspects of vestibular processing, while the flocculus remains specialized for eye movement recalibration via direct Purkinje cell inhibition of vestibular nuclei.^[26]

Development and Evolution

Embryological Development

The flocculus originates from the rhombic lip of the metencephalon, a neurogenic region derived from the alar plate of the developing hindbrain, beginning around the 5th week of gestation.^[27] This structure contributes to the early formation of the cerebellar primordium, with the flocculus emerging as part of the vestibulocerebellum.^[28] The developmental timeline of the flocculus begins with thickening of the alar plate during the 6th gestational week, forming an internal cerebellar bulge that progresses to outward bulges representing the primitive flocculi by the 7th week, delineated by the posterolateral fissures.^[29] The flocculus anlage becomes more defined by the 8th week, with Purkinje cell precursors migrating to establish the initial cortical layers around the 12th week.^[27] Full shaping of the flocculus occurs by the 12th–13th weeks, and cortical lamination, including the organization of Purkinje, granule, and molecular layers, is largely complete by birth, though the structure remains immature.^[29] Key genetic and molecular factors regulate this process. Atoh1 expression in rhombic lip progenitors is crucial for generating granule cell precursors that populate the flocculus.^[28] Reelin signaling from Cajal-Retzius cells guides the tangential migration and layering of Purkinje cells within the floccular cortex.^[30] Wnt signaling, particularly through Wnt1, influences zonal patterning and anterior-posterior organization of the developing cerebellum, including the flocculus region.^[31] Postnatally, the flocculus undergoes further maturation, with the external granular layer persisting until 1–2 years of age as granule cells migrate inward and differentiate.^[29] Synaptic refinement and circuit consolidation continue into early childhood, supported by activity-dependent mechanisms.^[32] Myelination of the inferior cerebellar peduncles, which connect the flocculus to brainstem nuclei, completes by approximately age 2, enhancing signal transmission efficiency.^[32] Developmental anomalies can disrupt flocculus formation. In Dandy-Walker malformation, hypoplasia of the cerebellar vermis often extends to the flocculonodular lobe, resulting in flocculus underdevelopment due to impaired midline fusion and fourth ventricle expansion during early gestation.^[33] This condition arises from genetic disruptions affecting rhombic lip-derived structures, leading to posterior fossa enlargement and potential hydrocephalus.^[34]

Comparative Anatomy Across Species

The flocculus represents a highly conserved component of the vertebrate cerebellum, present across all major vertebrate lineages from jawed fishes to mammals, where it contributes to gaze stabilization through integration of vestibular and visual inputs. Its size varies significantly relative to the overall cerebellar volume; for instance, the floccular fossa, which houses the flocculus and paraflocculus, is notably larger in some mammals like the mole (Talpa europaea, 2.34% of brain endocast volume) compared to others such as the red fox (Vulpes vulpes, 0.04%). In primates, the flocculus is particularly enlarged, accommodating the petrosal lobule (a dorsal paraflocculus region) that supports enhanced control of smooth pursuit eye movements and vestibulo-ocular reflexes (VOR), adaptations likely tied to the demands of arboreal and diurnal lifestyles.^[35]^[35]^[35] Among mammals, the microscopic organization of the flocculus shows strong similarities in Purkinje cell morphology and zoning. In rodents like rats and cats, Purkinje cells exhibit consistent two-dimensional dendritic arrays and trilaminate cortical architecture, with sagittal zonation patterns that align mossy and climbing fiber inputs for oculomotor control. Humans share this basic zoning but display more refined vestibular inputs to floccular Purkinje cells, reflecting adaptations for bipedal posture and balance during upright locomotion, where head movements differ statistically in velocity and acceleration from those in quadrupedal rodents.^[36]^[36]^[37] In non-mammalian vertebrates, analogous floccular structures fulfill similar roles in optokinetic reflexes (OKR), which compensate for self-motion to stabilize retinal images. Birds possess a prominent flocculus housed in a lateral fossa, integrating optic flow signals via mossy fibers from the basal optic nucleus to drive VOR and vestibulo-collic reflexes essential for flight and head stabilization. In bony fishes, direction-selective neurons in pretectal and cerebellar regions, including floccular analogs, sharpen OKR tuning for visual tracking during swimming. Sharks exhibit a more primordial flocculus form, primarily supporting basic gaze stabilization through less specialized visuo-vestibular pathways compared to bony fishes.^[38]^[38]^[39] The evolutionary expansion of the flocculus correlates with the transition to active predation and complex locomotion in gnathostome vertebrates, enhancing sensory-motor integration for dynamic environments; for example, larger floccular regions in archosaurs like birds support agile aerial pursuits. Experimental studies in accessible models like mice have elucidated conserved plasticity mechanisms in the flocculus, such as long-term depression (LTD) at parallel fiber-Purkinje cell synapses, which underlies VOR adaptation and is absent in LTD-deficient mutants, confirming its preservation across mammals; ferrets, with their gyrified cortex resembling primates, complement these models for studying visuomotor integration.^[40]^[41]^[42]

Clinical Significance

Pathological Conditions

Pathological conditions affecting the flocculus primarily arise from lesions, degenerative disorders, vascular events, or inflammatory processes, leading to disruptions in ocular motor control and vestibular function. Unilateral lesions of the flocculus typically result in ipsilateral gaze-holding failure, characterized by difficulty maintaining eccentric gaze positions, along with nystagmus and downbeat nystagmus, due to impaired inhibition of vestibular nuclei.^[43]^[44] Bilateral floccular lesions, in contrast, predominantly impair vestibulo-ocular reflex (VOR) adaptation, exacerbating deficits in smooth pursuit and gaze stabilization.^[45] The flocculus is implicated in several associated neurodegenerative and compressive disorders. In spinocerebellar ataxia type 6 (SCA6), mutations in the CACNA1A gene lead to Purkinje cell dysfunction in the flocculus, contributing to progressive ataxia, dysarthria, and impaired eye movement precision.^[46]^[47] Floccular atrophy is also observed in Parkinson's disease (as of 2024), contributing to balance impairments and gait disturbances.^[9] In 22q11.2 deletion syndrome, Tbx1 haploinsufficiency causes flocculus and paraflocculus dysplasia, leading to motor-learning deficits.^[48] Compression of the flocculus by vestibular schwannomas can cause disequilibrium, truncal ataxia, and nystagmus through mechanical disruption of cerebellar circuitry. Vascular pathologies, particularly infarction in the anterior inferior cerebellar artery (AICA) territory, can induce floccular ischemia, manifesting as acute vertigo and oscillopsia due to combined peripheral and central vestibular involvement.^[49]^[50] Infectious and inflammatory conditions also target floccular circuitry. Acute cerebellitis, an inflammatory disorder of the cerebellum often post-viral, can disrupt floccular function, resulting in ataxia and associated ocular motor abnormalities.^[51] Multiple sclerosis plaques in the flocculus or related pathways lead to circuitry interruptions, causing cerebellar ataxia and ocular dysmetria, where saccades overshoot or undershoot targets.^[52]^[53] Isolated floccular lesions are rare and typically occur within broader cerebellar syndromes, with prevalence data limited due to their infrequent isolated presentation.^[54] Prognosis varies, with partial recovery possible through cerebellar plasticity mechanisms, though outcomes are often influenced by the extent of surrounding damage and underlying etiology.^[55]

Diagnostic and Therapeutic Approaches

Diagnosis of floccular abnormalities primarily relies on neuroimaging techniques to detect structural changes such as atrophy, which is commonly observed in conditions like idiopathic downbeat nystagmus associated with floccular/parafloccular dysfunction. High-resolution magnetic resonance imaging (MRI) sequences, including fluid-attenuated inversion recovery (FLAIR), enable visualization of floccular atrophy by highlighting hyperintense signals in affected cerebellar regions and distinguishing degenerative changes from normal variants.^[56]^[57] Functional MRI (fMRI) further assesses circuitry activation during vestibulo-ocular reflex (VOR) tasks, revealing hypometabolism or reduced floccular activity in response to vertical smooth pursuit eye movements, which correlates with impaired gaze stabilization.^[58]^[59] Electrophysiological assessments complement imaging by quantifying functional deficits in eye movements and vestibular inputs. Electronystagmography (ENG) measures impaired saccades, smooth pursuit, and nystagmus, providing correlates to MRI findings in cerebellar oculomotor dysfunction and aiding differentiation of central from peripheral lesions.^[60] Caloric testing evaluates vestibular function by inducing nystagmus through thermal stimulation of the semicircular canals, revealing asymmetries or reduced VOR gain in floccular lesions, as demonstrated in longitudinal studies of the floccular syndrome.^[61] Therapeutic interventions target symptom management and functional adaptation in floccular-related disorders. Vestibular rehabilitation therapy (VRT) promotes neuroplasticity and adaptation of the VOR through customized exercises, improving balance and reducing oscillopsia in patients with downbeat nystagmus linked to floccular pathology.^[62] Pharmacological agents, such as baclofen, a GABA-B receptor agonist, control nystagmus by suppressing slow-phase velocity and alleviating visual symptoms, with oral doses of 5 mg three times daily yielding 25-75% reduction in four of five patients with downbeat or upbeat nystagmus.^[63] Surgical options address compressive or degenerative causes of floccular dysfunction. Microvascular decompression relieves vascular compression on adjacent structures during procedures for related cranial nerve disorders, indirectly benefiting floccular-mediated eye movement control by preserving cerebellar integrity.^[64] Deep brain stimulation (DBS), in experimental stages, targets the cerebellar dentate nucleus to modulate ataxic symptoms, with low-frequency stimulation (e.g., 20 Hz) improving motor coordination in degenerative ataxias affecting the flocculus.^[65] Recent advances post-2020 leverage optogenetic techniques in animal models to dissect floccular circuitry, informing potential human therapies for hereditary ataxias. Optogenetic stimulation of Purkinje cells in the flocculus has elucidated microzone-specific kinematics in eye movements, highlighting targets for restoring VOR adaptation in spinocerebellar ataxias.^[66] These insights support emerging gene therapies, such as antisense oligonucleotides for suppressing toxic gain-of-function mutations in hereditary cerebellar ataxias, which could preserve floccular function by halting Purkinje cell degeneration in conditions like SCA3.^[67]

References

[1]
Flocculus - e-Anatomy - IMAIOS
The flocculus is a small lobe of the cerebellum at the posterior border of the middle cerebellar peduncle anterior to the biventer lobule.
[2]
Flocculonodular Lobe - an overview | ScienceDirect Topics
The flocculonodular lobe, also known as the vestibulocerebellum, is the phylogenetically oldest part of the cerebellum and is composed of the paired flocculus ...
[3]
Flocculus - e-Anatomy - IMAIOS
Like other parts of the cerebellum, the flocculus is involved in motor control. It is an essential part of the vestibulo-ocular reflex, and aids in the learning ...
[4]
Flocculus (Cerebellar) - an overview | ScienceDirect Topics
The floccular complex of the cerebellum plays a key role in ocular motor behavior by modulating the activity of premotor neurons in the brainstem that control ...
[5]
Contribution of the cerebellar flocculus to gaze control during active ...
The flocculus and ventral paraflocculus are adjacent regions of the cerebellar cortex that are essential for controlling smooth pursuit eye movements.
[6]
pursuit: flocculus/vestibulocerebellum - NASA Courses for doctors
The flocculus and adjacent structures are important for gaze holding and stabilisation of visual images upon the retina, smooth pursuit eye movements.
[7]
Organization of the Cerebellum - Neuroscience - NCBI Bookshelf - NIH
This portion of the cerebellum comprises the caudal lobes of the cerebellum and includes the flocculus and the nodulus. As its name suggests, the ...
[8]
The inferior medullary velum: anatomical study and neurosurgical ...
Nov 16, 2012 · This structure most likely represents all that remains of the cortical continuity between the flocculus and nodule of the cerebellum.
[9]
Investigation of total cerebellar and flocculonodular lobe volume in ...
Apr 16, 2024 · In this study, we analyzed volumetric MRI results, comparing the cerebellum's total volume, gray matter volume, and the volume of the FL between ...
[10]
Cerebellar Artery - an overview | ScienceDirect Topics
The blood supply of the cerebellum is provided by the vertebrobasilar arterial system. ... flocculus to supply the inferior part of the petrosal surface.
[11]
CT and MR study. The vascular territories in the cerebellum and
The anterior inferior cere- bellar artery territory may be limited to the lateral inferior pontine and floccular regions but usually extends over the whole ...<|control11|><|separator|>
[12]
Cerebellum (Section 3, Chapter 5) Neuroscience Online
The cerebellum plays a major role in adapting and fine-tuning motor programs to make accurate movements through a trial-and-error process (e.g., learning to hit ...
[13]
Temporal Relations of the Complex Spike Activity of Purkinje Cell ...
Zonal organization of the rabbit flocculus and ventral nodulus. The five zones of the flocculus, the four zones of the ventral nodulus, and the origin of ...
[14]
Topsy Turvy: Functions of Climbing and Mossy Fibers in the ... - PMC
Two distinct afferent pathways convey information to the cerebellar cortex. Mossy fibers originate from multiple brainstem nuclei and terminate on granule cells ...
[15]
Floccular Modulation of Vestibuloocular Pathways and Cerebellum ...
Floccular stimulation significantly inhibited the vestibular-evoked discharges in oculomotor nerves on both sides and the inhibitory field potential in the ...Electrophysiological... · Discussion · Cerebellum-Related...
[16]
https://doi.org/10.1152/jn.1981.46.4.878
[17]
Occurrence of long-term depression in the cerebellar flocculus ... - NIH
Mar 27, 2018 · The cerebellum plays a critical role in motor learning, and a type of synaptic plasticity long-term depression (LTD) at parallel fiber (PF) to ...
[18]
CEREBELLAR CONTROL OF THE VESTIBULO-OCULAR REFLEX ...
In rabbit flocculus, five zones (I-V) have been distinguished in anatomical and physiological studies (Figure 1). Only one zone (II) has been related to the ...
[19]
Role of the flocculus in mediating vestibular nucleus neuron ... - NIH
How sustained changes in the intrinsic properties of MVN neurons may result from floccular plasticity involving mGluR1 and GR activation and protein ...
[20]
Gating of neural error signals during motor learning - eLife
Apr 22, 2014 · The climbing fiber input to Purkinje cells in the flocculus encodes the retinal slip that drives VOR learning (Simpson and Alley, 1974; ...
[21]
PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the ...
Apr 24, 2024 · To quantitatively evaluate the influence of postnatal develop- ment on both motor performance and motor learning across the entire life span, it ...
[22]
Cerebellum-mediated trainability of eye and head movements for ...
Nov 4, 2019 · GSEs can modulate eye movements with respect to head movements, and the cerebellum may be associated with eye–head coordination trainability for ...<|control11|><|separator|>
[23]
Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks ...
These data strongly support the hypothesis that activation of PKC in the Purkinje cell is necessary for cerebellar LTD induction.
[24]
The bidirectionality of motor learning in the vestibulo-ocular reflex is ...
Oct 6, 2010 · We conclude that bidirectional motor learning, like bidirectional synaptic plasticity,. 409 requires the activation of mGluR1 in the cerebellar ...
[25]
Optogenetic Control of Synaptic AMPA Receptor Endocytosis ...
Aug 16, 2018 · Using this tool, we demonstrate that LTD and AMPA receptor endocytosis at PF-Purkinje cell synapses in the flocculus are directly responsible ...
[26]
Internal models of self-motion: neural computations by the vestibular ...
Sep 20, 2023 · These cerebellar regions encode vestibular information and combine it with extravestibular signals to create internal models of eye, head, and body movements.
[27]
Neural - Cerebellum Development - Embryology
Aug 19, 2020 · 15–16 weeks (CRL 110–130 mm) - cerebellar hemisphere contained the primitive dentate nucleus. The nodule and flocculus were identified, vermis ...Introduction · Some Recent Findings · Development Overview · Cerebellar Cells
[28]
Consensus Paper: Cerebellar Development - PMC - PubMed Central
The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences.
[29]
https://doi.org/10.1007/978-3-031-26098-8_8
[30]
Cellular commitment in the developing cerebellum - PMC
Embryonic and early fetal development of the human cerebellum. Detailed morphologic descriptions of human cerebellum development in the embryonic period come ...
[31]
Regulation of early cerebellar development - Lowenstein - FEBS Press
Mar 9, 2022 · In this review, we focus on summarizing our current knowledge on early cerebellar development with a particular emphasis on the molecular determinants.The Ventricular Zone And The... · Granule Cell Development · Cerebellar Development At...Missing: timeline | Show results with:timeline
[32]
Cerebellar Development and Circuit Maturation - PubMed Central
Apr 2, 2020 · The cerebellum undergoes a profound change in terms of maturation and synaptic refinement during the first postnatal weeks, a process mediated ...
[33]
Analysis and Classification of Cerebellar Malformations - PMC
For example, when is the posterior fossa big enough to qualify for classification within the Dandy-Walker malformation continuum instead of vermian hypoplasia?
[34]
Dandy-Walker Malformation - StatPearls - NCBI Bookshelf - NIH
Nov 12, 2023 · This posterior fossa anomaly is characterized by agenesis or hypoplasia of the vermis and cystic enlargement of the fourth ventricle, causing ...
[35]
Floccular fossa size is not a reliable proxy of ecology and behaviour ...
May 17, 2017 · Abstract. The cerebellar floccular and parafloccular lobes are housed in fossae of the periotic region of the skull of different vertebrates.
[36]
Comparative neuronal morphology of the cerebellar cortex in ...
Apr 23, 2014 · To this end, we examine cortical neuronal morphology in the cerebella of eight different mammalian species comprising four diverse taxa: ...
[37]
The statistics of the vestibular input experienced during natural self ...
... vestibular input experienced during natural self‐motion differ between rodents ... mice and monkeys, and those previously published for humans (Carriot et al.Missing: flocculus | Show results with:flocculus
[38]
Avian Cerebellar Floccular Fossa Size Is Not a Proxy for Flying ... - NIH
Jun 25, 2013 · A primary role of the flocculus is to integrate sensory information about head rotation and translation to stabilize visual gaze via the ...
[39]
Comparative Neurobiology of the Optokinetic Reflex - Masseck - 2009
May 21, 2009 · In comparison to sharks, the bony fish optokinetic system seems to be more advanced, as their direction-selective neurons are sharply tuned, ...
[40]
The Significance of the Flocculus in Archosauria - Palaeocast
Jun 26, 2017 · The flocculi perform two important reflexes: the vestibulo-collic reflex (VCR), which acts to stabilise the head via impulses to the neck ...
[41]
Development, circuitry, and function of the zebrafish cerebellum - PMC
Jul 25, 2023 · The cerebellum represents a brain compartment that first appeared in gnathostomes (jawed vertebrates). Besides the addition of cell numbers, ...
[42]
Occurrence of long-term depression in the cerebellar flocculus ...
Mar 27, 2018 · The study found that long-term depression (LTD) occurs in the cerebellar flocculus during optokinetic response (OKR) adaptation, a type of ...Missing: ferrets | Show results with:ferrets
[43]
Effects of unilateral flocculus lesions on vestibulo-ocular responses ...
Ito M., Shiida T., Yagi N., Yamamoto M. Visual influence on rabbit's horizontal vestibulo-ocular reflex presumably effected via the cerebellar flocculus.
[44]
Vertical nystagmus: clinical facts and hypotheses | Brain
The main focal lesions resulting in DBN affect the cerebellar flocculus and/or paraflocculus. Apparently, this structure tonically inhibits the SVN and its ...
[45]
Partial Ablations of the Flocculus and Ventral Paraflocculus in ... - NIH
We conclude that 1) lesions of the floccular complex cause linked deficits in smooth pursuit and VOR adaptation, and 2) the relevant portions of the structure ...Missing: oscillopsia | Show results with:oscillopsia
[46]
Loss of Flocculus Purkinje Cell Firing Precision Leads to Impaired ...
Sep 2, 2022 · Thus, Purkinje cell morphology in the flocculus appears normal at disease onset. Any differences in behavior or Purkinje cell firing appear to ...Missing: zones | Show results with:zones
[47]
Entry - #183086 - SPINOCEREBELLAR ATAXIA 6; SCA6 - OMIM
Caused by expanded CAG trinucleotide repeats in the alpha-1A calcium channel subunit gene (CACNA1A, 601011.0007)
[48]
Neuro-Otological Aspects of Cerebellar Stroke Syndrome - PMC
Cerebellar infarction is a common cause of a vascular vestibular syndrome and vertigo/dizziness is the most common manifestation of cerebellar stroke.Missing: oscillopsia | Show results with:oscillopsia
[49]
Vascular vertigo and dizziness: Diagnostic criteria - Sage Journals
An acute prolonged vestibular syndrome consists of continuous vertigo/dizziness, imbalance, oscillopsia, vegetative symptoms such as nausea and vomiting, or ...
[50]
Imaging Spectrum of Cerebellar Pathologies: A Pictorial Essay - PMC
Dandy-Walker malformation(which forms the most severe end of the spectrum) can be differentiated from the Dandy-Walker variant (Figure 1) by the presence of ...
[51]
Cerebellar Dysfunction in Multiple Sclerosis - PMC - PubMed Central
Jun 28, 2017 · Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability.Missing: flocculus ocular dysmetria
[52]
Cerebellum and Ocular Motor Control - Frontiers
Purkinje cells of the cerebellar cortex primarily project to and inhibit cells within the underlying deep cerebellar nuclei; the vestibulocerebellum (flocculus, ...
[53]
Dynamic Changes in Eye Movements and Vestibulo-ocular Reflex in ...
The cerebellar flocculus is a critical structure involved in the control of eye movements. Both static and dynamic abnormalities of the vestibulo-ocular reflex ...
[54]
Advances in the Diagnosis and Treatment of Vestibular Disorders
Apr 1, 2015 · As expected, recovery from central lesions is usually less complete than with peripheral lesions because the brain structures required for ...
[55]
Structural and functional MRIs disclose cerebellar pathologies in ...
Aug 6, 2025 · 15 As mentioned above DBN is often caused by a bilaterally impaired function of the flocculus/paraflocculus 16 often associated with an atrophy ...
[56]
A new MRI marker of ataxia with oculomotor apraxia - ScienceDirect
According to patient's data, absence of DN hypointensity on FLAIR for diagnosis of AOA has a specificity of 81, 25% and a sensitivity of 100% while absence of ...
[57]
Functional brain imaging of peripheral and central vestibular disorders
May 30, 2008 · FMRI activity of both flocculi is significantly diminished during downward but not during upward pursuit in DBN. Results of the ...
[58]
Detection of floccular hypometabolism in downbeat nystagmus by fMRI
Aug 6, 2025 · The authors evaluated floccular activity with fMRI during the performance of vertical smooth pursuit eye movements in four patients with ...
[59]
ENG-MRI Correlates in Cerebellar Oculomotor Dysfunction
This study correlates ENG and MRI findings in six patients with cerebellar eye movements. For each subject, both tests independently support the presence of ...
[60]
Dynamic Changes in Eye Movements and Vestibulo-ocular Reflex in ...
Apr 1, 2018 · The cerebellar flocculus is a critical structure involved in the control of eye movements. Both static and dynamic abnormalities of the ...Missing: vestibulocerebellum paper
[61]
Downbeat Nystagmus: Case Report, Updated Review, Therapeutics ...
5.1. Vestibular Rehabilitation Therapy (VRT) is a highly individualized, exercise-based treatment program fundamentally designed to promote vestibular ...
[62]
(PDF) The effect of baclofen and cholinergic drugs on upbeat and ...
Aug 5, 2025 · Baclofen (orally, 5 mg three times daily) reduced nystagmus slow phase velocity and distressing oscillopsia by 25-75% in four out of five ...
[63]
Microvascular Decompression for Hemifacial Spasm Associated ...
The hypothesis of vascular compression as a cause of HFS is established by the disappearence of involuntary facial movement just after MVD. The common offending ...
[64]
Deep cerebellar stimulation reduces ataxic motor symptoms in ... - NIH
Low-frequency deep cerebellar stimulation may provide a novel strategy for treating motor symptoms of degenerative cerebellar ataxias.
[65]
Purkinje cell microzones mediate distinct kinematics of a single ...
Jul 19, 2023 · First, the flocculus is a sensorimotor structure that integrates vestibular, visual, visuo-motor and proprioceptive sensory inputs to drive ...
[66]
Gene Suppression Therapies in Hereditary Cerebellar Ataxias - MDPI
Introduction: Hereditary cerebellar ataxias (HCAs) are a heterogenous group of neurodegenerative disorders associated with severe disability.Missing: flocculus | Show results with:flocculus